chunk_id int64 1M 11.9M | document stringlengths 3 4.98k | embedding listlengths 384 384 |
|---|---|---|
10,010,703 | Human peripheral blood lymphocytes (PBL), obtained from patients with a variety of cancers, were incubated in vitro with phytohemagglutinin, concanavalin A, and crude or lectin-free T-cell growth factors. The lectin-activated PBL of nine patients were capable of lysing fresh autologous tumor during a 4-hr 51Cr release ... | [
-0.021777218207716942,
-0.01082282792776823,
-0.041702765971422195,
-0.03327905014157295,
0.05582525208592415,
0.04285994917154312,
0.024762414395809174,
0.0666532814502716,
0.07114855945110321,
0.025612659752368927,
-0.027081724256277084,
0.08536674082279205,
-0.022481558844447136,
0.0294... |
10,010,704 | Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine. | [
0.05262599140405655,
-0.04511246457695961,
0.030110374093055725,
0.003305514110252261,
-0.03538190573453903,
0.014201711863279343,
0.04749023914337158,
0.09718312323093414,
0.002516272244974971,
-0.031267035752534866,
-0.08559224754571915,
-0.0741075798869133,
0.05925072729587555,
-0.05295... |
10,010,705 | The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the lipophilic antifolate, metoprine. M5076 cells were markedly deficient in mediated entry of methotrexate. This was in contrast to the L1210 leukemia, a tumor highly responsive to methotrexate but poorl... | [
0.007173826452344656,
-0.060718145221471786,
-0.022667070850729942,
-0.016697829589247704,
0.02120775729417801,
0.0013391810934990644,
0.031050849705934525,
0.1069331243634224,
-0.012059458531439304,
-0.026966433972120285,
-0.068253293633461,
-0.01403930876404047,
0.06794613599777222,
-0.0... |
10,010,706 | Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines. | [
-0.02920158952474594,
-0.00886264443397522,
-0.0681367740035057,
-0.08536815643310547,
-0.012716549448668957,
0.03735879063606262,
-0.0005611784872598946,
0.14302746951580048,
0.04318556189537048,
0.016541915014386177,
-0.027202431112527847,
-0.04111921414732933,
0.06839125603437424,
0.053... |
10,010,707 | Twenty clones stably resistant to 5-fluorouracil, 5-fluoro-2'-deoxyuridine, or 5-fluorouridine have been isolated from L1210 or P388 murine leukemia cells by a one-step mutation and selection procedure. The activities of enzymes of the pyrimidine salvage pathway relevant to the activation of these drugs have been deter... | [
-0.027159128338098526,
-0.030083797872066498,
-0.06486421078443527,
-0.10338512063026428,
0.04695301875472069,
0.011165210977196693,
-0.06734219938516617,
0.06607420742511749,
0.0429144948720932,
0.06687159091234207,
-0.010549989528954029,
0.004146114457398653,
0.004467223770916462,
0.0689... |
10,010,708 | Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential. | [
0.06078101694583893,
0.010039456188678741,
-0.018113747239112854,
-0.006765636149793863,
0.021078763529658318,
0.06466060131788254,
0.013694762252271175,
0.04710213840007782,
0.015842294320464134,
0.04429378733038902,
-0.12784938514232635,
0.0007595216738991439,
-0.017216050997376442,
0.06... |
10,010,709 | In solid s.c. tumors of a variant of the murine B16 melanoma with high metastatic potential (B16F10), there was a 2- to 7-fold elevation of lysosomal cathepsin B activity when compared to the B16F1 variant with low metastatic potential. The highest activities (based on either protein or DNA) of cathepsin B were found i... | [
0.03204257786273956,
-0.05243782699108124,
-0.05028025060892105,
-0.04064585268497467,
0.018978973850607872,
0.05861230194568634,
0.0004724661121144891,
0.06138664111495018,
-0.009808403439819813,
0.014920196495950222,
-0.0867195650935173,
0.029143184423446655,
-0.014982594177126884,
0.045... |
10,010,710 | Mechanism of efflux of melphalan from L5178Y lymphoblasts in vitro. | [
0.008981049992144108,
0.012585780583322048,
-0.02086617797613144,
0.004919182509183884,
-0.0020849891006946564,
0.0681060254573822,
-0.01643073558807373,
0.03170972317457199,
0.014250507578253746,
0.0037833128590136766,
-0.035401541739702225,
-0.006292164325714111,
0.033224742859601974,
0.... |
10,010,711 | The mechanism of efflux of melphalan from L5178Y lymphoblasts in vitro was investigated. Evidence was obtained that drug efflux occurs by a process different from the influx mechanism. A time course of efflux followed a first-order process for at least 5 min, with a rate constant K of 0.13 +/- 0.05 (S.D.) min-1, and ap... | [
0.06061602011322975,
-0.0746116116642952,
-0.02445019781589508,
-0.014103971421718597,
-0.029911823570728302,
0.06000319868326187,
0.013926416635513306,
0.10195274651050568,
0.06226296350359917,
0.014423033222556114,
-0.035133879631757736,
0.036437004804611206,
0.08443140983581543,
0.06332... |
10,010,712 | Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. | [
0.0007649902254343033,
-0.0981753021478653,
-0.08681327849626541,
0.04234614223241806,
0.07576197385787964,
0.10536938160657883,
-0.029210051521658897,
0.014252587221562862,
-0.010488316416740417,
0.00375430379062891,
0.05985810607671738,
0.015617778524756432,
0.006608215626329184,
-0.0409... |
10,010,713 | Glutathione (GSH) S-transferase is a major detoxification enzyme system that catalyzes the binding of a variety of electrophiles, including reactive forms of chemical carcinogens, to GSH. Green coffee beans fed in the diet induced increased GSH S-transferase activity in the mucosa of the small intestine and in the live... | [
-0.0056654601357877254,
-0.08200503140687943,
-0.054840534925460815,
0.012447085231542587,
0.08968961238861084,
0.1176389753818512,
-0.039395276457071304,
0.03965109586715698,
0.016393473371863365,
0.0003647838020697236,
0.05122916027903557,
-0.024720674380660057,
0.021537620574235916,
-0.... |
10,010,714 | Effect of butylated hydroxyanisole, alpha-angelica lactone, and beta-naphthoflavone on benzo(alpha)pyrene:DNA adduct formation in vivo in the forestomach, lung, and liver of mice. | [
0.01273842342197895,
-0.054100554436445236,
-0.02340238355100155,
0.047525715082883835,
0.045966263860464096,
0.09603659063577652,
-0.024474309757351875,
0.07678287476301193,
-0.02866828814148903,
-0.033356547355651855,
-0.007421727292239666,
0.07635003328323364,
-0.10005241632461548,
0.02... |
10,010,715 | The effects of alpha-angelica lactone (alpha-AL), butylated hydroxyanisole (BHA), and beta-naphthoflavone (beta-NF) on the amount of benzo(alpha)pyrene (BP) metabolite:DNA adducts formed in the forestomach, lung, and liver of ICR/Ha mice were investigated 48 hr after p.o. administration of BP. BP was administered to mi... | [
-0.026138201355934143,
-0.03934618830680847,
-0.05775393173098564,
0.018421737477183342,
0.0061188568361103535,
0.10760477930307388,
0.02522137574851513,
0.10627074539661407,
-0.002743486547842622,
-0.00846484862267971,
0.006569696590304375,
0.05277394503355026,
-0.09004315733909607,
0.003... |
10,010,716 | Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate. | [
0.0701424777507782,
-0.08590931445360184,
-0.10914316773414612,
-0.000046237553760875016,
0.052126601338386536,
0.1151939183473587,
-0.05419233441352844,
0.06694405525922775,
0.038616109639406204,
-0.058890171349048615,
0.022219236940145493,
0.0287182554602623,
0.004783601965755224,
-0.009... |
10,010,717 | The effects of feeding p-methoxyphenol, benzyl isothiocyanate, coumarin, alpha-angelicalactone, 2-tert-butyl-4-hydroxyanisole, and 3-tert-butyl-4-hydroxyanisole on the glutathione S-transferase activity and sulfhydryl levels of esophagus and small bowel mucosa of ICR/Ha mice have been investigated. p-Methoxyphenol, ben... | [
0.014730315655469894,
-0.12992846965789795,
-0.0729505717754364,
0.03322305157780647,
0.039268214255571365,
0.08489850163459778,
-0.060373492538928986,
0.06716085225343704,
0.061546970158815384,
-0.02469489723443985,
-0.04304848611354828,
0.08264275640249252,
-0.0490458719432354,
0.0212966... |
10,010,718 | Factors that influence initiation and growth of 9L rat brain gliosarcoma multicellular spheroids. | [
0.032636936753988266,
-0.06525944918394089,
-0.029553906992077827,
-0.06795904785394669,
-0.017943626269698143,
-0.015845617279410362,
0.026221012696623802,
0.016221405938267708,
0.005816970020532608,
0.005893100053071976,
0.0345660038292408,
0.036924418061971664,
-0.023950643837451935,
-0... |
10,010,719 | This report details optimum conditions for initiating and growing 9L rat brain gliosarcoma multicellular spheroids. Best results were achieved when 0.5 to 2.0 x 10(6) cells were seeded initially into agarose (0.5 to 1.0%)-coated Petri dishes. Spheroids initiated in this manner appeared to grow in spinner culture at a r... | [
0.012525385245680809,
-0.08119642734527588,
-0.04709341377019882,
-0.05786513537168503,
-0.06904593855142593,
-0.03136123716831207,
-0.006174509879201651,
0.01681656762957573,
0.0015154631109908223,
0.016537658870220184,
0.046551354229450226,
0.005163335707038641,
-0.049943868070840836,
-0... |
10,010,720 | Effects of tumor-promoting phorbol diesters on neoplastic progression of Syrian hamster embryo cells. | [
0.006333301309496164,
0.016053449362516403,
-0.0016696503153070807,
-0.11938848346471786,
0.015211394988000393,
0.02498158998787403,
-0.025986935943365097,
0.005483006127178669,
0.0558600127696991,
0.04408489540219307,
0.0047032181173563,
0.04896211624145508,
0.007885269820690155,
-0.05345... |
10,010,721 | The progression of normal Syrian hamster embryo cells to a neoplastic phenotype after treatment with a chemical carcinogen and continuous exposure to phorbol ester tumor promoters was studied in cell culture. Tumor promoters were able to rescue cell lines derived from individual carcinogen-treated colonies from a progr... | [
0.01092193741351366,
-0.012200494296848774,
-0.029365217313170433,
-0.06833212077617645,
0.018185511231422424,
0.03976763039827347,
-0.004842042922973633,
0.021618032827973366,
0.03096148930490017,
0.0291130468249321,
0.010056285187602043,
0.04240575060248375,
0.020902754738926888,
-0.0173... |
10,010,722 | Influence of bay-region methyl group on formation of 5-methylchrysene dihydrodiol epoxide:DNA adducts in mouse skin. | [
0.014764375053346157,
-0.03279006853699684,
0.011962911114096642,
0.0040561603382229805,
0.1189853623509407,
0.0033121583983302116,
0.057660188525915146,
0.031579624861478806,
-0.05798861011862755,
0.006052539683878422,
0.0745258554816246,
0.009706446900963783,
-0.0697476714849472,
-0.0433... |
10,010,723 | The binding of tritium-labeled 5-methylchrysene to DNA of CD-1 mouse skin 24 hr after treatment has been studied. DNA was isolated from the treated skin areas of mice and hydrolyzed enzymatically to deoxyribonucleosides, and the hydrolysate was chromatographed on a Sephadex LH-20 column using a methanol:water gradient.... | [
-0.027402237057685852,
-0.022292889654636383,
-0.022705230861902237,
-0.04408102482557297,
0.06357237696647644,
0.03613585978746414,
0.058679573237895966,
0.0853525847196579,
-0.08013838529586792,
-0.02378552034497261,
0.03193909302353859,
0.014250224456191063,
-0.046745527535676956,
-0.04... |
10,010,724 | Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver. | [
0.034923624247312546,
-0.04395059868693352,
0.015478186309337616,
-0.04562147334218025,
0.009342304430902004,
-0.0018480356084182858,
-0.025877194479107857,
0.04297410324215889,
0.0021838329266756773,
0.016149183735251427,
-0.08759728074073792,
-0.033542200922966,
0.031102333217859268,
-0.... |
10,010,725 | The metabolism of the mutagen and carcinogen, 5-nitroacenaphthene, by the 9000 x g supernatant from the livers of Aroclor-pretreated rats was studied. The major primary metabolites were 1-hydroxy-5-nitroacenaphthene and 2-hydroxy-5-nitroacenaphthene. These metabolites were oxidized to 1-oxo-5-nitroacenaphthene and 2-ox... | [
0.001199810765683651,
-0.06077086925506592,
0.029955925419926643,
-0.03192372992634773,
0.008853577077388763,
0.02288823388516903,
0.02945464663207531,
0.051889460533857346,
-0.011668406426906586,
0.02597612328827381,
-0.049162160605192184,
0.03335941955447197,
0.03510584682226181,
0.00034... |
10,010,726 | Depletion of lymphocyte subpopulations in primary and secondary lymphoid organs of mice by a transplanted granulocytosis-inducing mammary carcinoma. | [
0.046042416244745255,
-0.03828177601099014,
-0.0014466685242950916,
-0.08661846816539764,
0.02566312626004219,
-0.025251686573028564,
0.0682884231209755,
0.06363483518362045,
0.04561687260866165,
-0.020102567970752716,
-0.03132890909910202,
0.00855817086994648,
0.0988585501909256,
-0.00260... |
10,010,727 | Transplanted CE mammary carcinoma causes a marked increase in the production of neutrophilic granulocytes in mice associated with the expansion of hemopoietic marrow into the peripheral skeleton. Changes in lymphocyte populations in the femoral marrow, the expanding peripheral marrow, and the spleen were examined for a... | [
-0.005748060066252947,
-0.03151603415608406,
-0.0475887730717659,
-0.08569427579641342,
0.005142868962138891,
0.034683480858802795,
0.050798140466213226,
0.06837788224220276,
0.048947371542453766,
0.0031827716156840324,
-0.01234414428472519,
0.004913488868623972,
0.0766017735004425,
-0.023... |
10,010,728 | Response of human hematopoietic precursor cells (CFUc) to hyperthermia and radiation. | [
0.010423162952065468,
0.017855677753686905,
-0.07894112169742584,
0.08441052585840225,
-0.024107743054628372,
0.013657030649483204,
0.02869732491672039,
0.07654065638780594,
0.02065688744187355,
0.02917543798685074,
-0.009346487000584602,
-0.06097789853811264,
-0.028940744698047638,
-0.016... |
10,010,729 | Currently, whole-body and local hyperthermia is being evaluated in clinical studies as a potential method of cancer treatment. Since the hyperthermic sensitivity of normal human bone marrow cells is not known, we have studied the in vitro response of these cells to two anticancer modalities when administered alone or i... | [
-0.004661699756979942,
0.022898348048329353,
-0.05265077203512192,
0.03752458840608597,
-0.01317441463470459,
-0.033171091228723526,
0.03156761825084686,
0.10248815268278122,
0.022937508299946785,
0.06880944222211838,
-0.023052766919136047,
-0.026734337210655212,
0.08979908376932144,
0.025... |
10,010,730 | Cyclic nucleotide modulation of in vitro morphological transformation of Syrian hamster cells. | [
0.02734643779695034,
0.03836860880255699,
0.03402307257056236,
-0.12643885612487793,
-0.08433043211698532,
0.004616863094270229,
-0.02034100331366062,
-0.0069443341344594955,
0.07006952166557312,
0.08442138880491257,
0.032341595739126205,
0.04035491868853569,
-0.008058088831603527,
-0.0222... |
10,010,731 | The cyclic nucleotides, cyclic adenosine 3':5'-monophosphate (cAMP) and cyclic guanosine 3':5'-monophosphate (cGMP) or their dibutyryl and monobrominated derivatives, may either increase or decrease morphological transformation of Syrian hamster embryo cells exposed to N-methyl-N'-nitro-N'-nitrosoguanidine (MNNG). The ... | [
0.004562337417155504,
0.015076451934874058,
0.04353395849466324,
-0.0704713836312294,
-0.012997311539947987,
0.04100528359413147,
-0.014209844172000885,
0.07475084811449051,
0.0252842977643013,
0.08713067322969437,
0.01626591384410858,
0.010165541432797909,
0.020031655207276344,
0.04441414... |
10,010,732 | Enterohepatic circulation of methotrexate in rats in vivo. | [
0.09213226288557053,
-0.10539911687374115,
0.012908806093037128,
0.06587396562099457,
-0.10727622359991074,
0.009910767897963524,
0.050157636404037476,
0.08630084246397018,
-0.00145849643740803,
-0.013765314593911171,
-0.1108589917421341,
0.019558370113372803,
0.027007803320884705,
0.01332... |
10,010,733 | The pharmacokinetics of the methotrexate enterohepatic cycle were studied in rats in vivo. For plasma levels of methotrexate between 10(-5) and 10(-8) M, biliary levels were directly proportional and concentrated 27-fold. When labeled methotrexate was administered in doses sufficient to achieve plasma levels of 10(-6) ... | [
0.08378846943378448,
-0.12028393149375916,
0.03085913509130478,
0.04328707233071327,
-0.1254735291004181,
-0.019659196957945824,
0.001466740039177239,
0.11101631820201874,
0.04688034951686859,
-0.027779892086982727,
-0.09281690418720245,
0.01966341771185398,
0.04528484493494034,
-0.0047734... |
10,010,734 | Biochemical localization of aryl hydrocarbon hydroxylase in the intestinal epithelium of the rat. | [
0.047925714403390884,
-0.06029625982046127,
-0.0593770369887352,
-0.035374823957681656,
-0.008266148157417774,
0.03329155966639519,
0.0325273722410202,
-0.02287476137280464,
-0.010309885255992413,
-0.055560167878866196,
-0.014213582500815392,
-0.03883427381515503,
-0.05736985057592392,
0.0... |
10,010,735 | The distribution of the carcinogen-metabolizing enzyme system, aryl hydrocarbon hydroxylase (AHH), was biochemically determined in the intestinal epithelium of the rat. A method of epithelial cell isolation in which fractions of cells are sequentially collected as a villus tip-to-crypt gradient was used. AHH activity w... | [
0.017059821635484695,
-0.023820683360099792,
-0.06308121234178543,
-0.03814098984003067,
0.023150986060500145,
0.022322461009025574,
0.019939979538321495,
0.045568935573101044,
0.04545634239912033,
-0.01635371521115303,
0.01957329921424389,
-0.009673123247921467,
0.025431429967284203,
0.03... |
10,010,736 | Identification of 7-carboxymethylguanine in DNA from pancreatic acinar cells exposed to azaserine. | [
-0.006779149174690247,
-0.0033131984528154135,
-0.03564105182886124,
-0.007873639464378357,
-0.030784206464886665,
0.08055226504802704,
0.06509903818368912,
0.06843553483486176,
0.013588347472250462,
0.022880038246512413,
0.0008934244397096336,
0.03978409618139267,
0.006217915564775467,
0.... |
10,010,737 | Studies were undertaken to determine the identity of an azaserine:DNA adduct. The most probable adduct, 7-carboxymethylguanine, was synthesized. DNA isolated from pancreatic acinar cells treated in culture with [14C]azaserine was hydrolyzed under neutral conditions to liberate N-alkylated purines. The neutral hydrolysa... | [
-0.02941744215786457,
-0.04860686883330345,
-0.04859133064746857,
-0.019962327554821968,
-0.06365799158811569,
0.07513214647769928,
0.0513869933784008,
0.04357882961630821,
-0.009973345324397087,
0.04226594790816307,
0.0029772724956274033,
0.04921899735927582,
-0.024739323183894157,
0.0375... |
10,010,738 | Initial rate kinetics of the transport of adenosine and 4-amino-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (tubercidin) in cultured cells. | [
0.07311417907476425,
-0.06638484448194504,
-0.07403413206338882,
-0.10522797703742981,
-0.0487799346446991,
0.0546824112534523,
0.011274874210357666,
0.0821337103843689,
0.04817137122154236,
0.08226502686738968,
0.027776185423135757,
0.04752803221344948,
-0.007986770942807198,
0.0848421752... |
10,010,739 | A procedure is described for determining early time courses of nucleoside uptake by cultured cells in suspension. Replicate samples of cell suspensions were exposed to medium containing 3H-nucleosides for brief intervals (sec) ended by addition of nitrobenzylthioinosine, a potent inhibitor of nucleoside transport that ... | [
0.07120461016893387,
-0.10307654738426208,
-0.026066835969686508,
-0.059315476566553116,
-0.014673706144094467,
0.03453193977475166,
0.01739170216023922,
0.09355174750089645,
0.06434508413076401,
0.02773919142782688,
-0.008015726692974567,
0.06603580713272095,
0.06233438476920128,
0.116113... |
10,010,740 | Metabolism of N-nitrosamines by cultured human and rat esophagus. | [
0.06242429092526436,
-0.023618558421730995,
-0.08979407697916031,
-0.0339059941470623,
-0.05981715768575668,
-0.020328179001808167,
0.03598613291978836,
0.010429622605443,
0.04373641312122345,
-0.026520855724811554,
-0.04706459864974022,
0.002543338341638446,
-0.047146059572696686,
-0.0019... |
10,010,741 | The metabolism of several N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosobenzylmethylamine, and N-nitrosopyrrolidine) in cultured human and rat esophagus has been investigated by measuring (a) CO2, (b) metabolites with an oxo group, and (c) metabolites bound to DNA. B... | [
0.060232244431972504,
-0.02182215452194214,
-0.10081592947244644,
-0.04196584224700928,
-0.020810285583138466,
-0.00008926720329327509,
0.002392958151176572,
0.0425199456512928,
0.02437068521976471,
-0.02669021300971508,
-0.01154649630188942,
0.01784636825323105,
-0.027418777346611023,
0.0... |
10,010,742 | Formation and removal of (guan-8-yl)-DNA-2-acetylaminofluorene adducts in liver and kidney of male rats given dietary 2-acetylaminofluorene. | [
-0.006493779364973307,
-0.10350818932056427,
-0.003403210546821356,
-0.013347873464226723,
-0.01601124182343483,
-0.06682451069355011,
0.04400605708360672,
0.02979365363717079,
-0.05352200195193291,
-0.016778849065303802,
0.10415433347225189,
0.014403218403458595,
-0.10020734369754791,
0.0... |
10,010,743 | Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, subst... | [
-0.01730182021856308,
-0.04298669472336769,
-0.047372329980134964,
0.029695291072130203,
-0.08414763957262039,
-0.025134654715657234,
0.014775892719626427,
0.09472700208425522,
-0.06748858094215393,
0.02858656458556652,
0.05652644857764244,
-0.02714124135673046,
-0.08325737714767456,
0.055... |
10,010,744 | Repair and replication of DNA in hereditary (bilateral) retinoblastoma cells after X-irradiation. | [
-0.031254157423973083,
0.018786408007144928,
-0.038515910506248474,
0.006769127212464809,
-0.033413082361221313,
-0.004314722027629614,
0.04934464767575264,
0.030092917382717133,
-0.0272049643099308,
0.01938667520880699,
0.06735827773809433,
0.0747547522187233,
0.015280883759260178,
-0.016... |
10,010,745 | Fibroblasts from patients with hereditary retinoblastoma reportedly exhibit increased sensitivity to killing by X-rays. Although some human syndromes with similar or greater hypersensitivity to DNA-damaging agents (e.g., X-rays, ultraviolet light, and chemical carcinogens), such as xeroderma pigmentosum, are deficient ... | [
-0.009723137132823467,
-0.022421199828386307,
-0.014761796221137047,
0.005263637285679579,
0.00667192367836833,
-0.0015367609448730946,
0.05024797469377518,
0.05587576702237129,
-0.057974737137556076,
0.037016212940216064,
0.03840983286499977,
0.08196615427732468,
0.003165397560223937,
0.0... |
10,010,746 | Inhibition of the R3327MAT-Lu prostatic tumor by diethylstilbestrol and 1,2-bis(3,5-dioxopiperazin-1-yl)propane. | [
0.015598438680171967,
-0.014418070204555988,
-0.0790429562330246,
-0.0075385249219834805,
0.06686438620090485,
-0.04448295012116432,
0.01858607679605484,
0.09611213952302933,
0.038233041763305664,
-0.002991090063005686,
-0.057036250829696655,
0.053297024220228195,
-0.007703346665948629,
0.... |
10,010,747 | We have previously described the inhibitory effects of diethylstilbestrol on the growth of the androgen-independent, anaplastic Copenhagen rat prostatic tumor, R3327AT, which has a low metastatic potential. We have now selected a variant of the R3327AT tumor that metastasizes exclusively to the lungs, and we have desig... | [
0.05149758979678154,
0.014083725400269032,
-0.06687334924936295,
-0.022997593507170677,
0.062444865703582764,
-0.0166439488530159,
-0.003791568335145712,
0.09656534343957901,
0.04977203905582428,
0.0027964760083705187,
-0.05181732773780823,
0.08448959141969681,
-0.00028669380117207766,
0.0... |
10,010,748 | Alteration of protein synthesis and induction of specific protein phosphorylation by hyperthermia. | [
0.011297912336885929,
-0.018144061788916588,
-0.015137859620153904,
0.11030703783035278,
0.019108111038804054,
0.0696648582816124,
0.061379529535770416,
0.003059034002944827,
0.010647590272128582,
0.04368804395198822,
-0.02170221321284771,
0.023589737713336945,
0.024504419416189194,
0.0287... |
10,010,749 | Confluent cultures of the mouse cell line clone 1D were subjected to 1-hr hyperthermic treatments. Temperatures were increased from the control level of 37 degrees to values ranging from 38 to 45 degrees. Protein synthesis patterns were determined in fluorograms of sodium dodecyl sulfate-polyacrylamide gels labeled wit... | [
-0.06382151693105698,
-0.09092846512794495,
-0.007449922151863575,
-0.018730534240603447,
-0.05404533073306084,
-0.008946794085204601,
0.05980720743536949,
0.0218503475189209,
0.053333595395088196,
0.07937399297952652,
0.011050616391003132,
0.00555197661742568,
0.03117479383945465,
0.02369... |
10,010,750 | Proliferative and morphological changes in the pulmonary epithelium of the Syrian golden hamster during carcinogenesis initiated by 210Po alpha alpha-radiation. | [
0.06588763743638992,
0.030170628800988197,
0.022418571636080742,
-0.09751575440168381,
-0.028553109616041183,
-0.01958329603075981,
0.030905552208423615,
0.02512526884675026,
0.0199041198939085,
0.04291151836514473,
0.05974134802818298,
0.02752285823225975,
0.028011390939354897,
0.03233703... |
10,010,751 | The role of cellular proliferation in a two-stage model of carcinogenesis in the hamster lung was investigated. Syrian golden hamsters were treated intratracheally with either one instillation of 0.2 microCi of 210Po (Po-0 group), seven weekly instillations of BP (0-BP group), or 0.2 microCi 210Po followed 15 weeks lat... | [
0.10365419834852219,
0.03192633017897606,
-0.021612226963043213,
-0.05034894496202469,
-0.006226439960300922,
-0.00681259436532855,
0.035671595484018326,
0.043937720358371735,
0.03703715652227402,
0.05640972778201103,
0.05493670701980591,
0.022322863340377808,
0.05092459172010422,
0.036018... |
10,010,752 | Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. | [
0.03901832923293114,
-0.09639165550470352,
-0.029776260256767273,
0.023310596123337746,
-0.05108087137341499,
-0.06675971299409866,
0.004375026561319828,
0.037650056183338165,
0.03660634532570839,
-0.011702977120876312,
-0.007164036389440298,
0.06306499242782593,
-0.018287768587470055,
0.0... |
10,010,753 | Functional and ultrastructural studies of liposomes injected i.v. into inbred C57BL/6N mice were performed to determine whether free liposomes can traverse capillaries. In the liver and spleen, organs with discontinuous (sinusoidal) capillaries, ultrastructural and cell fractionation studies revealed that small (300- t... | [
0.04509557783603668,
-0.08963435143232346,
-0.011217803694307804,
0.0007987223216332495,
0.013842484913766384,
-0.03337060287594795,
-0.06614861637353897,
0.012202509678900242,
0.010252886451780796,
0.06035612151026726,
-0.03185480087995529,
-0.05977467820048332,
-0.02803615666925907,
0.07... |
10,010,754 | Metabolic and ultrastructural aspects of the in vitro lysis of chronic lymphocytic leukemia cells by glucocorticoids. | [
-0.0689426138997078,
-0.04015277326107025,
-0.07582837343215942,
-0.017284175381064415,
-0.10437151789665222,
0.032812315970659256,
0.004714779555797577,
0.0862751379609108,
0.002729494124650955,
0.01720503717660904,
-0.08020918071269989,
0.10195627808570862,
-0.053291067481040955,
-0.0629... |
10,010,755 | Human chronic lymphocytic leukemia (CLL) cells like prothymocytes and immunoactivated T-lymphocytes are readily lysed in vitro by pharmacological concentrations of glucocorticoids such as cortisol, whereas peripheral blood lymphocytes and thymocytes are unaffected by the hormone. In this study, metabolic and ultrastruc... | [
-0.019898217171430588,
-0.018865272402763367,
-0.018117016181349754,
0.01739606261253357,
0.0006230616709217429,
0.06791217625141144,
0.012430036440491676,
0.03451637178659439,
0.060926008969545364,
0.03301215544342995,
-0.0350346677005291,
0.024151599034667015,
0.037294093519449234,
0.003... |
10,010,756 | Distribution of Novikoff ascites hepatoma antigens p39 and p49 in various tumorigenic cell lines. | [
-0.03748256340622902,
-0.04582405090332031,
-0.11704189330339432,
-0.07125791907310486,
-0.10036994516849518,
0.02653615176677704,
-0.0025435190182179213,
0.09067581593990326,
-0.026090269908308983,
0.02352825552225113,
0.016860567033290863,
0.02876400761306286,
-0.02956182137131691,
0.031... |
10,010,757 | This study investigates the specificity of two antigenic proteins with molecular weights of 39,000 and 49,000, respectively (p39 and p49), present in Novikoff ascites hepatoma. Chromatins and cytosol fractions were assayed from a number of tumorigenic cell lines by identifying antigenic species immunologically on nitro... | [
-0.02876463532447815,
-0.04399744048714638,
-0.1013256162405014,
-0.07783437520265579,
-0.07483593374490738,
0.04548981040716171,
0.0920957550406456,
0.10544777661561966,
0.06183791905641556,
-0.00015564457862637937,
0.003786681918427348,
-0.003941554110497236,
0.013668833300471306,
0.0135... |
10,010,758 | Mutagenic and alkylating activities of 3-methyl-1-phenyltriazenes and their possible role as carcinogenic metabolites of the parent dimethyl compounds. | [
-0.01132873073220253,
-0.039365340024232864,
-0.004019218031316996,
-0.032166145741939545,
0.013534448109567165,
-0.008688118308782578,
0.03272685036063194,
0.034335553646087646,
0.036921050399541855,
0.020672421902418137,
-0.01425510086119175,
-0.026503238826990128,
0.01788359507918358,
0... |
10,010,759 | 3-Methyl-1-phenyltriazene and a series of ring-substituted derivatives (4-methylphenyl, 4-chlorophenyl, and 2,4,6-trichlorophenyl), structurally related benzenediazonium fluoborates and phenyl azides, as well as the recently isolated [1-methyl-3-(2,4,6-trichlorophenyl)-2-triazeno]methyl-beta-D-glucopyranoside uronic ac... | [
0.007023066747933626,
-0.07673166692256927,
-0.03440285474061966,
-0.06663214415311813,
-0.004641271196305752,
0.0059136515483260155,
0.046461381018161774,
0.060500774532556534,
0.07833166420459747,
0.0023619718849658966,
0.01070175040513277,
-0.0022949997801333666,
0.00897924229502678,
0.... |
10,010,760 | Properties of human melanoma cells resistant to 5-(3',3'-dimethyl-1-triazeno)imidazole-4-carboxamide and other methylating agents. | [
0.03505859524011612,
0.05458320304751396,
-0.017374932765960693,
-0.017400536686182022,
-0.0020573202054947615,
0.04417625069618225,
0.06357543170452118,
0.0747637003660202,
-0.032522883266210556,
0.05075382441282272,
-0.0063629550859332085,
-0.09078530967235565,
-0.049870867282152176,
0.0... |
10,010,761 | 4'-O-tetrahydropyranyladriamycin as a potential new antitumor agent. | [
0.003689645091071725,
-0.037865445017814636,
-0.07962396740913391,
-0.08992055803537369,
0.02174130454659462,
-0.0708991214632988,
-0.0019425293430685997,
0.08588181436061859,
0.07067645341157913,
-0.010256186127662659,
0.009957038797438145,
0.04581795632839203,
0.07480970025062561,
0.0574... |
10,010,762 | Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum inc... | [
-0.007631797809153795,
0.032677777111530304,
-0.03809983655810356,
-0.07278550416231155,
-0.07010313868522644,
-0.058671027421951294,
0.048022396862506866,
0.11791787296533585,
0.021532293409109116,
0.04138818755745888,
0.006503146607428789,
0.10176026821136475,
0.10768425464630127,
-0.007... |
10,010,763 | Inhibition by 17 beta-estradiol of the growth of the rat pituitary transplantable tumor MtF4. | [
0.08063158392906189,
0.019310321658849716,
-0.0137252826243639,
-0.020547887310385704,
0.07584665715694427,
0.027273569256067276,
0.055858857929706573,
-0.04514123499393463,
-0.01369668822735548,
0.03684568777680397,
0.03257918730378151,
-0.0236528217792511,
0.010903519578278065,
0.0118582... |
10,010,764 | pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes. | [
0.020117944106459618,
-0.04630795121192932,
0.04433756694197655,
-0.05914566293358803,
-0.08375848084688187,
0.05727635324001312,
0.06944582611322403,
-0.008823991753160954,
0.028337638825178146,
0.018321970477700233,
0.07127556204795837,
-0.016246134415268898,
0.06431587785482407,
0.05068... |
10,010,765 | The distribution of pH values was measured in transplanted neuroectodermal TV1A tumors and in brain and kidney of BDIX rats in vivo. Tissue damage during pH measurements could be minimized by the use of Hinke-type pH glass microelectrodes with maximum diameters of the pH-sensitive tips of less than or equal to 10 micro... | [
0.03374781459569931,
-0.05156252160668373,
0.06348294019699097,
-0.0734960287809372,
-0.0685790628194809,
0.0007025827071629465,
0.07548858970403671,
0.08185932785272598,
0.032829493284225464,
0.01795400306582451,
0.021861635148525238,
-0.0209310632199049,
0.03309937193989754,
0.0597011707... |
10,010,766 | Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. | [
0.027973545715212822,
0.04231127351522446,
-0.019820308312773705,
0.014826287515461445,
0.022600723430514336,
0.017765168100595474,
0.07638590037822723,
-0.01785195991396904,
0.012853539548814297,
0.06447084248065948,
-0.048349324613809586,
0.0605594776570797,
-0.001503242994658649,
0.0039... |
10,010,767 | The pH distributions in transplanted neural (TV1A, BT1A) and hepatic (HV1A3) tumors and in brain and kidney of BDIX rats were analyzed as a function of serum glucose concentration (SGC), tumor size, and tissue architecture. Tissue damage during pH measurements in vivo could be minimized by the use of pH microelectrodes... | [
0.006853872444480658,
-0.003707053605467081,
0.011009935289621353,
-0.02311638370156288,
-0.055847592651844025,
0.04832661896944046,
0.07303913682699203,
0.0287003330886364,
0.024345969781279564,
0.023507462814450264,
-0.02644953690469265,
0.04203177988529205,
0.033855970948934555,
-0.0074... |
10,010,768 | Serotonin and histamine production by human carcinoid cells in culture. | [
0.06473103165626526,
0.0025864969938993454,
-0.05543221905827522,
-0.032589636743068695,
-0.06251516193151474,
0.054157596081495285,
0.05226842686533928,
-0.000381797639420256,
0.0167374424636364,
0.00588624645024538,
-0.042160920798778534,
-0.056369148194789886,
0.00024393887724727392,
-0... |
10,010,769 | We are reporting on the first human carcinoid cells ever cultured in vitro. These cells, termed CGP, originated from a jejunal carcinoid tumor. Before tumor resection, the 29-year old male patient presented high levels of blood serotonin and histamine and also of urinary serotonin and 5-hydroxyindole-acetic acid; value... | [
-0.04462996497750282,
-0.03749687969684601,
-0.06633995473384857,
-0.024012751877307892,
-0.09718605875968933,
0.02690761908888817,
0.015804970636963844,
0.05022227764129639,
0.052041467279195786,
-0.02448401041328907,
-0.057413261383771896,
-0.04404550418257713,
-0.01782801002264023,
-0.0... |
10,010,770 | Elevated level of enzymatic DNA methylation in cells treated with 1-beta-D-arabinofuranosylcytosine. | [
0.012941301800310612,
0.0124936169013381,
-0.0381300188601017,
-0.04662034288048744,
-0.09457214921712875,
0.02587875910103321,
-0.031401194632053375,
0.07354293018579483,
-0.016195613890886307,
0.0020109964534640312,
0.005616593174636364,
0.07928772270679474,
0.012650251388549805,
-0.0388... |
10,010,771 | When mouse P815 mastocytoma cells are cultured in the presence of 1-beta-D-arabinofuranosylcytosine (ara-C), a dose-dependent inhibition of cell proliferation and DNA synthesis can be observed. The DNA synthesized in the presence of ara-C is more highly enzymatically methylated than that of controls as measured by conv... | [
-0.05216076970100403,
0.04637349396944046,
-0.07357004284858704,
-0.019056741148233414,
-0.023361317813396454,
0.00583691569045186,
-0.00816258229315281,
0.05478510633111,
-0.031169964000582695,
0.013525733724236488,
0.05827269330620766,
0.04327007755637169,
-0.05555396154522896,
0.0484742... |
10,010,772 | Pteridine-binding alpha 1-acid glycoprotein from blood of patients with neoplastic diseases. | [
-0.0034500788897275925,
-0.03972269967198372,
-0.07909934222698212,
-0.020049361512064934,
-0.022194452583789825,
-0.026928622275590897,
0.09398586302995682,
0.08027476817369461,
-0.03719475492835045,
-0.016906512901186943,
-0.009454640559852123,
0.0901157334446907,
-0.05172101408243179,
-... |
10,010,773 | A glycoprotein was selectively enriched in the supernatant (Fraction b) obtained by alcohol and trichloroacetic acid fractionation of digitonin extracts from blood of patients with neoplastic diseases and of control subjects. Subsequent chromatography with concanavalin A:Sepharose separated a concanavalin A-reactive fr... | [
-0.015573649667203426,
-0.10622265934944153,
-0.11521344631910324,
-0.020935485139489174,
0.03512097895145416,
0.05598185211420059,
0.06204179301857948,
0.10516445338726044,
0.008387849666178226,
-0.03723423555493355,
0.0389971099793911,
0.07066388428211212,
-0.03590301424264908,
0.0059378... |
10,010,774 | Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients. | [
0.006844355724751949,
-0.05053608492016792,
-0.09092426300048828,
-0.030176056548953056,
-0.05014878138899803,
-0.021568315103650093,
0.06961826235055923,
0.05067768320441246,
-0.00031346050673164427,
-0.06384581327438354,
0.009757112711668015,
0.03828508034348488,
-0.0715465247631073,
-0.... |
10,010,775 | A variant of alpha 1-acid glycoprotein was found previously in blood of malignant cases. It had been characterized as a pteridine-binding alpha 1-acid glycoprotein (P-AGPM). P-AGPM as well as the corresponding fraction of control origin were selectively enriched in the supernatant (Fraction b), obtained after digitonin... | [
-0.0438319630920887,
-0.04886807128787041,
-0.1270129233598709,
-0.05064091458916664,
0.04734853655099869,
0.04706288501620293,
0.0638926699757576,
0.13379661738872528,
0.061915624886751175,
-0.03745521605014801,
0.015493500977754593,
0.07570842653512955,
-0.07748948037624359,
0.0160118024... |
10,010,776 | Phase I trial and pharmacokinetics of aziridinylbenzoquinone (NSC 182986) in humans. | [
-0.009875528514385223,
-0.026752779260277748,
-0.08474807441234589,
0.018629472702741623,
-0.05446391552686691,
-0.0006223905947990716,
0.04858425259590149,
0.12212634086608887,
0.06150021776556969,
0.007096792571246624,
-0.00594482384622097,
0.056056857109069824,
0.09303423017263412,
0.10... |
10,010,777 | 2,5-Diaziridinyl-3,6-(carboethoxyamino)-1,4-benzoquinone (AZQ) is a rationally designed antitumor agent which possesses sufficient lipid solubility to allow central nervous system penetration as well as adequate aqueous solubility for drug formulation and administration. We have conducted a Phase I trial of AZQ in 40 p... | [
-0.016321050003170967,
0.0058647762052714825,
-0.05520278960466385,
-0.01113049779087305,
-0.09467349201440811,
-0.009828676469624043,
0.03635557368397713,
0.13158130645751953,
0.07712407410144806,
-0.03293510153889656,
-0.06297116726636887,
0.04866476356983185,
0.12273389101028442,
0.0629... |
10,010,778 | Polymorphonuclear functions in Hodgkin's disease patients at diagnosis, in remission, and in relapse. | [
0.012163630686700344,
-0.026324685662984848,
0.0222330205142498,
-0.031563472002744675,
-0.05376295745372772,
-0.026392072439193726,
0.018585454672574997,
0.06436828523874283,
0.01663387380540371,
-0.026547089219093323,
-0.005913864821195602,
0.1159605085849762,
-0.0038961467798799276,
0.0... |
10,010,779 | Five tests investigating different aspects of the nonspecific defense mechanisms including capillary tube random migration, particle ingestion activity, quantitative and histochemical nitroblue tetrazolium dye reduction by polymorphonuclear neutrophils, and serum lysozyme concentrations were performed in 46 patients wi... | [
0.06650292128324509,
-0.01599189080297947,
-0.013156144879758358,
-0.0004186294099781662,
0.07962481677532196,
0.014420120976865292,
0.047079868614673615,
0.1255934089422226,
0.021277975291013718,
0.029404617846012115,
-0.014179890044033527,
0.016561226919293404,
0.03475145995616913,
0.089... |
10,010,780 | Amyloid A in systemic amyloidosis associated with cancer. | [
0.001841365359723568,
-0.09233761578798294,
0.021377189084887505,
0.0008426125277765095,
-0.03501110151410103,
-0.06970582157373428,
0.10074590146541595,
0.01018325611948967,
0.11272801458835602,
-0.038804326206445694,
0.017391104251146317,
0.07663920521736145,
0.01218463759869337,
-0.0486... |
10,010,781 | Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. Th... | [
-0.0666889026761055,
-0.09486376494169235,
0.02866498753428459,
-0.03006742335855961,
-0.05185902491211891,
-0.04394350200891495,
0.09721797704696655,
0.05427134409546852,
0.12350152432918549,
-0.02832367643713951,
-0.04586031660437584,
0.024847431108355522,
0.061526812613010406,
0.0301946... |
10,010,782 | Differential effect of high-dose methotrexate on erythropoiesis and granulocytopoiesis in humans. | [
0.05666772276163101,
-0.05325058847665787,
0.023708179593086243,
0.03208436816930771,
-0.085626982152462,
-0.013692944310605526,
0.07866990566253662,
0.16184508800506592,
0.014754578471183777,
-0.006555527914315462,
-0.12349311262369156,
0.012753001414239407,
0.034561384469270706,
-0.03771... |
10,010,783 | The kinetics of erythroid and granulocytopoietic cell production were investigated during Courses 1 and 4 of high-dose methotrexate therapy with citrovorum factor rescue in a patient suffering from metastatic osteogenic sarcoma. Using the technique of quantitative 14C autoradiography, relative production rates were det... | [
0.020037250593304634,
-0.03297208994626999,
-0.05100703984498978,
-0.020150398835539818,
-0.04168242961168289,
0.006173714064061642,
-0.0048193191178143024,
0.18562091886997223,
0.026093970984220505,
0.05181535705924034,
-0.09911983460187912,
0.013880140148103237,
0.028311409056186676,
-0.... |
10,010,784 | A methodologically improved definition of chemosensitivity indices. | [
0.03870461508631706,
-0.08815987408161163,
0.0023968827445060015,
0.07345720380544662,
0.022074151784181595,
0.012992323376238346,
0.13505974411964417,
0.10781916975975037,
0.06145413592457771,
-0.06298980116844177,
-0.01084701344370842,
-0.06341791152954102,
0.03909743204712868,
0.0435302... |
10,010,785 | Rationale for the use of alternating non-cross-resistant chemotherapy. | [
-0.00014893773186486214,
0.010653403587639332,
-0.020899778231978416,
-0.03994549438357353,
0.00490741478279233,
-0.01502398680895567,
-0.025300398468971252,
0.12754712998867035,
0.038879163563251495,
0.028156297281384468,
0.0393730103969574,
0.06451927870512009,
0.03893604874610901,
-0.02... |
10,010,786 | Multiple myeloma resistant to melphalan: treatment with doxorubicin, cyclophosphamide, carmustine (BCNU), and prednisone. | [
-0.0047850944101810455,
0.1267123967409134,
-0.002527449280023575,
-0.061692625284194946,
-0.08732711523771286,
-0.03193823993206024,
-0.013578470796346664,
0.1259673684835434,
0.02091858722269535,
0.02937406860291958,
-0.11418689787387848,
-0.02236589416861534,
0.11121653765439987,
0.0055... |
10,010,787 | Sixty-five patients with multiple myeloma resistant to melphalan were randomized to receive cyclophosphamide, doxorubicin (Adriamycin), and prednisone (CAP) (30 patients) or carmustine (BCNU), doxorubicin, and prednisone (BAP) (35 patients). Objective responses occurred in two patients in the CAP group and in seven in ... | [
-0.005694281309843063,
0.061942052096128464,
-0.010876640677452087,
-0.07176123559474945,
-0.05781923234462738,
-0.03374599665403366,
-0.007378016132861376,
0.19087935984134674,
0.04420766606926918,
0.04529886692762375,
-0.12400677055120468,
-0.000948284869082272,
0.10481629520654678,
-0.0... |
10,010,788 | Hemolytic-uremic syndrome associated with mitomycin therapy. | [
-0.051429860293865204,
0.020372530445456505,
-0.07149716466665268,
0.022013338282704353,
-0.07160299271345139,
-0.05893079563975334,
0.0615617074072361,
0.1604282259941101,
0.06984546780586243,
-0.02072436548769474,
-0.06715917587280273,
0.01955585367977619,
0.0631275475025177,
0.064644977... |
10,010,789 | Influence of renal failure on myelosuppressive effects of melphalan: Cancer and Leukemia Group B experience. | [
0.0384729839861393,
0.0427556075155735,
0.03208101913332939,
-0.026783199980854988,
-0.08287771791219711,
-0.021295996382832527,
0.028002958744764328,
0.08576319366693497,
0.007960772141814232,
-0.06906098872423172,
-0.1652640849351883,
0.008282731287181377,
0.07241915166378021,
-0.0150448... |
10,010,790 | The influence of renal insufficiency on melphalan-induced myelosuppression was examined during the initial 10 weeks of treatment in 295 patients with multiple myeloma. Patients were randomized to receive either oral melphalan (0.15 mg/kg/day for 7 days, followed by 0.05 mg/kg/day after recovery from the wbc count nadir... | [
0.021165452897548676,
0.041274845600128174,
0.022792011499404907,
-0.03451352193951607,
-0.11811181902885437,
-0.0475592166185379,
-0.005967610515654087,
0.18080855906009674,
0.03394618257880211,
0.03261125832796097,
-0.1440732777118683,
0.038789283484220505,
0.058554548770189285,
0.026124... |
10,010,791 | High-dose doxorubicin: an exploration of the dose-response curve in human neoplasia. | [
0.07172215729951859,
-0.0013754625106230378,
-0.03980940952897072,
-0.0016558070201426744,
-0.029379092156887054,
-0.08215410262346268,
0.008470214903354645,
0.17403165996074677,
0.10081826895475388,
-0.08377619832754135,
0.002544867340475321,
0.0566394217312336,
0.06787706911563873,
0.083... |
10,010,792 | Twenty-seven patients with advanced solid tumors (ten with lung cancer, eight with sarcoma, five with melanoma, four with miscellaneous tumors) were treated with high-dose doxorubicin (120 mg/m2) every 3 weeks for a total of 75 courses. As expected, marked myelosuppression was observed, with all patients having a granu... | [
0.07316631078720093,
0.022511905059218407,
-0.10019059479236603,
-0.04918927326798439,
-0.04457434266805649,
-0.11278843879699707,
0.0015772527549415827,
0.17066335678100586,
0.0738033801317215,
-0.04828516021370888,
-0.08639562129974365,
0.046313121914863586,
0.09021877497434616,
0.074417... |
10,010,793 | Studies on the pharmacokinetics and metabolism of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) in the dog. | [
-0.03198029100894928,
-0.045635614544153214,
0.018047351390123367,
0.08716783672571182,
-0.10794072598218918,
-0.054970014840364456,
0.03914822265505791,
0.10441838949918747,
0.0007202564738690853,
-0.026451822370290756,
-0.008196210488677025,
0.019702695310115814,
0.026892969384789467,
0.... |
10,010,794 | cis-Dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) (CHIP), a new antineoplastic platinum compound, was administered iv to dogs at a dose of 10 mg/kg. Thin-layer chromatography and high-pressure liquid chromatography (HPLC) were used to evaluate the pharmacokinetics of total Pt and of unchanged drug separated ... | [
-0.052198801189661026,
-0.009044856764376163,
0.02425968647003174,
0.012256531044840813,
-0.02784542739391327,
-0.07927585393190384,
0.04908531904220581,
0.16125370562076569,
0.018572814762592316,
-0.005035825539380312,
0.013630341738462448,
0.0807911679148674,
-0.011390453204512596,
0.059... |
10,010,795 | Enhanced lymph node uptake of melphalan following liposomal entrapment and effects on lymph node metastasis in rats. | [
0.04028590768575668,
-0.016644690185785294,
-0.024442093446850777,
0.010517718270421028,
-0.019966324791312218,
0.016329023987054825,
0.018187420442700386,
0.02642945386469364,
0.027785155922174454,
0.026431694626808167,
-0.058615852147340775,
0.03248460963368416,
0.011348946951329708,
0.0... |
10,010,796 | Randomized phase II comparison of methotrexate with or without L-asparaginase in non-small cell cancer of the lung. | [
0.052780505269765854,
-0.053787726908922195,
-0.03081367164850235,
0.002139694755896926,
-0.024442704394459724,
0.01561215240508318,
-0.06320000439882278,
0.13648761808872223,
0.06631123274564743,
-0.02978002093732357,
-0.0188000425696373,
0.049438007175922394,
0.04175914078950882,
-0.0542... |
10,010,797 | Response of hypereosinophilic syndrome to 6-thioguanine and cytarabine. | [
-0.02660713903605938,
-0.017990481108427048,
-0.031414132565259933,
-0.015895534306764603,
-0.1235920786857605,
0.051476579159498215,
0.03254256024956703,
0.10902118682861328,
-0.007957037538290024,
0.06152790039777756,
-0.051037345081567764,
-0.001634197891689837,
-0.03872176259756088,
0.... |
10,010,798 | Radiation therapy combined with intra-arterial 5-FU chemotherapy for treatment of localized adenocarcinoma of the pancreas: a Southwest Oncology Group Study. | [
0.10781941562891006,
0.022444242611527443,
0.01762966439127922,
-0.03566417843103409,
-0.010453456081449986,
-0.09596309810876846,
0.01711800880730152,
0.017934884876012802,
0.05501032993197441,
0.03017312102019787,
-0.06633863598108292,
-0.002091342117637396,
-0.00007505287794629112,
0.01... |
10,010,799 | Phase II trial of razoxane (ICRF-159) in patients with squamous cell carcinoma of the head and neck previously exposed to systemic chemotherapy. | [
0.023399081081151962,
-0.02164597064256668,
-0.09636706113815308,
-0.05275331065058708,
0.018401047214865685,
-0.07945634424686432,
-0.019448038190603256,
0.09168757498264313,
0.008212973363697529,
0.028400054201483727,
0.04762883111834526,
0.015371584333479404,
0.0650683045387268,
0.01099... |
10,010,800 | Third-line chemotherapy with mitomycin, vinblastine, and carmustine (BCNU) in refractory breast carcinoma: a pilot study. | [
-0.05765249952673912,
-0.02048211358487606,
-0.09332574903964996,
-0.04993515461683273,
-0.06184540316462517,
-0.017691969871520996,
-0.05412779375910759,
0.06957126408815384,
0.014666923321783543,
-0.07336371392011642,
-0.028481466695666313,
-0.013780987821519375,
0.14857646822929382,
-0.... |
10,010,801 | Cerebrospinal fluid versus serum concentrations of 5-FU, allopurinol, and oxypurinol during treatment of metastatic brain cancer with 5-FU infusion, allopurinol, and radiation. | [
0.08325497806072235,
-0.014984862878918648,
-0.0007794024422764778,
-0.011332075111567974,
0.10373123735189438,
-0.022077525034546852,
0.05581764504313469,
0.049394458532333374,
0.04103567823767662,
-0.010303670540452003,
-0.00642590643838048,
-0.06070011481642723,
-0.030748771503567696,
0... |
10,010,802 | A pilot study of Estracyt in advanced breast cancer. | [
0.054133009165525436,
-0.1343642622232437,
-0.14303351938724518,
0.04082579165697098,
0.02869606576859951,
-0.017988821491599083,
-0.01945066638290882,
0.014780288562178612,
-0.023001980036497116,
-0.05834605544805527,
0.0014574179658666253,
-0.030160965397953987,
-0.11781945079565048,
0.0... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.