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10,003,700 | Severe hypertension was seen in a patient with mitral stenosis when in sinus rhythm. A large fall in systolic blood pressure and in left ventricular end-diastolic pressure was caused by ventricular pacing. Contrary to the usual situation in mitral stenosis this patient paradoxically is a subject who improved haemodynam... | [
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10,003,701 | Effects of halothane and sodium nitroprusside on renal function and autoregulation. | [
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10,003,702 | The effects of sodium nitroprusside and halothane on renal autoregulation and kidney function were studied in 14 mongrel dogs at mean arterial pressures of 120, 100, 80, 60 and 40 mm Hg. In group 1, stepwise decreases in mean arterial pressure were achieved by increasing the halothane concentration. In group II, mean a... | [
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10,003,703 | Malposition of a central venous catheter. | [
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10,003,704 | Pancuronium and nodal rhythm. | [
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10,003,705 | Continuous suxamethonium infusion for microlaryngeal surgery. | [
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10,003,706 | The suxamethonium infusion requirements to maintain a 100% neuromuscular block in patients undergoing microlaryngeal surgery were determined. Anaesthesia was maintained with halothane and the neuromuscular block monitored with a peripheral nerve stimulator delivering train-of-four stimuli. Suxamethonium requirements va... | [
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10,003,707 | Antagonism of ketamine by 4-aminopyridine and physostigmine. | [
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10,003,708 | Remote monitoring by mass spectrometry during anaesthesia. Evaluation of a suitable inlet system. | [
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10,003,709 | We describe a three-stage mass spectrometer inlet system suitable for use in operating theatres and evidence of its performance in delay and response times to step changes in oxygen and halothane concentrations. At 55 m and a sampled gas flow of 100mlmin-1, the inlet imposed a delay of 21s and prolonged the 10-90% resp... | [
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10,003,710 | Influence of extradural morphine on the adrenocortical and hyperglycaemic response to surgery. | [
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10,003,711 | Plasma cortisol and glucose concentrations were measured repeatedly from before the induction of anaesthesia until 9 h after skin incision in 36 patients undergoing abdominal hysterectomy. Twelve patients received general anaesthesia (halothane), and systemic opiates for postoperative pain; a further 12 patients underw... | [
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10,003,712 | Suppression of antidiuretic hormone hypersecretion during surgery by extradural anaesthesia. | [
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10,003,713 | The concentrations of antidiuretic hormone in plasma and urine were determined in three groups of patients submitted to the same operative procedure. Seven (group I) underwent general anaesthesia with thiopentone, fentanyl and nitrous oxide and received an infusion of isotonic saline solution 5ml min-l. Seven patients ... | [
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10,003,714 | Comparison of i. m. diazepam and hydroxyzine as premedicants. | [
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10,003,715 | The effectiveness of diazepam as premedication when administered by two different i.m. techniques was compared with hydroxyzine in 84 male and 101 female patients. Variables studied were relief of anxiety, sedation, acceptance by both patient and anaesthetist and pain at the injection site. Diazepam 20 mg in male and d... | [
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10,003,716 | Single-dose comparison of buprenorphine 0.3 and 0.6 mg i.v. given after operation: clinical effects and plasma concentration. | [
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10,003,717 | The plasma concentrations and clinical effects of a single i.v. dose of buprenorphine 0.3 or 0.6 mg were studied in patients recovering from surgery. Analgesic and hormonal effects were greater with the greater dose without a parallel increase in respiratory depression. A comparison with previous work suggests that inc... | [
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10,003,718 | Effects of the inhalation of enflurane on hepatic microsomal enzymatic activities in the rat. | [
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10,003,719 | We have investigated the possible hepatic microsomal enzyme induction effect of enflurane, administered by inhalation in anaesthetic doses for periods of 1 h a day. In 15 experimental groups, differing from one another in anaesthetics concentration (1, 2 and 3% enflurane) and in the number of days of treatment (3, 7, 1... | [
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10,003,720 | The IgG binding function of the normal red cell plasma membrane: identification of integral polypeptides that bind IgG. | [
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10,003,721 | Non-immune IgG binds to red cell integral membrane proteins obtained by mild alkaline extraction of ghosts. Detergent gel chromatography and electrophoretic analyses of IgG-membrane protein complexes obtained by nonionic detergent solubilization and affinity binding to protein A indicate that three polypeptides partici... | [
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10,003,722 | Comparison of antithrombin III assays using biological and chromogenic substrates. | [
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10,003,723 | Antithrombin III (At III) levels in plasma samples were determined by incubation of diluted plasma with thrombin, either with or without heparin. Followed by measurement of residual thrombin using clotting and amidolytic methods. All assays were of multidose bioassay design suitable for parallel line analysis. Assays w... | [
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10,003,724 | Polymorphonuclear leucocyte hypersegmentation in heat stroke. | [
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10,003,725 | Ristocetin-induced platelet agglutination in Afro-Caribbean and Caucasian people. | [
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10,003,726 | Endotoxin in paroxysmal nocturnal haemoglobulinuria (PNH) | [
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10,003,727 | Erythrocytes with different surface immunological properties in the peripheral blood of beta-thalassaemic patients. | [
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10,003,728 | Erythrocyte membrane proteins in an unusual case of congenital dyserythropoietic anaemia type II (CDA II). | [
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10,003,729 | Analysis of the erythrocyte membrane protein of an atypical case of congenital dyserythropoietic anaemia type II (CDA II) by electrophoresis on polyacrylamide gels revealed marked abnormalities. One-dimensional analysis showed a pronounced decrease in levels of B1.1 components, an increase in the level of B1.4 and the ... | [
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10,003,730 | Molecular ferrokinetics in the rabbit. | [
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10,003,731 | Using urea-polyacrylamide gel electrophoresis it has been possible to distinguish the molecular forms of transferrin in rabbit serum. When 59Fe-labelled diferric transferrin is injected into normal, anaemic or hypertransfused, polycythaemic rabbits, iron is removed from diferric transferrin in essentially pairwise fash... | [
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10,003,732 | A new perspective on Bruch's membrane and the retinal pigment epithelium. | [
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10,003,733 | Trypsin digestion of retinal pigment epithelium is a technique that bares Bruch's membrane, to allow topographical examination by scanning electron microscopy. Twenty-five human eyes were examined. The zonula occludens of the pigment epithelium was clearly seen as a surface feature, but attachment plaques at the sides ... | [
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10,003,734 | Preserved para-arteriole retinal pigment epithelium (PPRPE) in retinitis pigmentosa. | [
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10,003,735 | Five patients with retinitis pigmentosa (RP) with probable autosomal recessive inheritance have been identified in whom there is relative preservation of retinal pigment epithelium adjacent to and under retinal arterioles despite a panretinal degenerative process. All the patients were hypermetropic, though patients wi... | [
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10,003,736 | The age variation of "senile' cataract in various parts of the world. | [
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10,003,737 | As its name implies, senile cataract is age-related. A survey of 9 studies indicates to what extent the epidemiology of senile cataract can be represented by Gompertz plots. These are shown to be suitable separately for men and women and to enable one to distinguish between inborn and environmental influences. Further ... | [
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10,003,738 | Prevalence and aetiology of cataract in Punjab. | [
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10,003,739 | Three districts in the Punjab plains were surveyed in 1976-7 for senile cataract and potential risk factors. The prevalence of senile cataract was 15.3% among 1269 persons examined who were aged 30 ang older, and 4.3% for all ages. These figures confirmed previous reports of high prevalence. The prevalence was 1% for a... | [
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10,003,740 | Expulsive choroidal haemorrhage: an experimental study. | [
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10,003,741 | The closure of 2 or more vortex veins in rabbits' eyes results in a persistent rise in intraocular pressure. In these circumstances a small opening into the anterior chamber at the corneoscleral limbus resulted in an iris prolapse, while a larger limbal wound was immediately followed by a massive choroidal expulsive ha... | [
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10,003,742 | Visual disorders associated with cerebral palsy. | [
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10,003,743 | School children severely afflicted with cerebral palsy, but unselected in regard to their visual status. have been studied. Of 120 children examined only 24 (20%) had normal eyes or ocular adnexae. Squint was found in 52.5% of the children and significant refractive errors in 50%. There was also a high incidence of str... | [
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10,003,744 | Intraocular lens power calculation for emmetropia: a clinical study. | [
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10,003,745 | A series of 50 eyes received an intraocular lens (IOL) of power calculated for emmetropia from data of axial length, corneal curvature, and postoperative anterior chamber depth by R. D. Binkhorst's formulae. The postoperative refraction results were compared with those of 100 control eyes which received +19 D standard ... | [
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10,003,746 | Binocular interactions in normal and anomalous binocular vision: effects of flicker. | [
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10,003,747 | Temporal modulation thresholds were determined for monocular viewing and for binocular viewing of stimuli presented in phase or in counterphase to each eye of observers with normal binocular vision and those lacking stereopsis. The results showed that in individuals with normal binocular vision sensitivity was much gre... | [
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10,003,748 | The sensitive period: transfer of fixation after occlusion for strabismic amblyopia. | [
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... |
10,003,749 | Of 2649 patients with strabismic amblyopia who attended clinics between 1941 and 1978, 1904 patients were reviewed. Of these, 115 patients had transfer of fixation after occlusion. These were analysed according to the type of transfer of fixation and relation to occlusion and age. The period of maximum sensitivity to s... | [
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10,003,750 | Lacrimal canalicular obstruction following chickenpox. | [
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10,003,751 | Parallel measurements of bound calcium and force in glycerinated rabbit psoas muscle fibers. | [
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10,003,752 | A simple double-isotope procedure has been developed for making simultaneous measurements of bound Ca2+ and relative force in glycerinated rabbit psoas bundles containing two fibers. With this preparation it is possible to study Ca2+-troponin interactions coincident with MgATP-induced force development. Over the free [... | [
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10,003,753 | Transport of Na+ by monensin across bimolecular lipid membranes. | [
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10,003,754 | Transmembrane 22Na fluxes across bimolecular lipid membranes are measured under two different experimental conditions: (a) the pH is the same in the two bulk aqueous solutions on either side of the membrane while the concentrations of Na+ are different; (b) the concentration of Na+ are identical but pH of the two solut... | [
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0.133... |
10,003,755 | Sodium uptake mechanisms in brush-border membrane vesicles prepared from rabbit renal cortex. | [
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10,003,756 | Transport of glucosamine (aldohexoses) by preimplantation mouse blastocysts. | [
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10,003,757 | A carrier-mediated system for uptake of glucosamine (and other aldohexoses) was identified in preimplantation mouse blastocysts. With early and late blastocysts, the values for Km (525 +/- 82 and 651 +/- 137 microM, respectively) and V (0.29 +/- 0.02 and 0.29 +/- 0.04 pmol/h per ng protein, respectively) for glucosamin... | [
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10,003,758 | Stabilization of bilayer structure for unsaturated phosphatidylethanolamines by detergents. | [
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10,003,759 | The structural preferences of mixed lipid systems containing egg yolk or 18:1c/18:1c phosphatidylethanolamine and representative detergents (Triton X-100, deoxycholate, octylglucoside and lyso-phosphatidylcholine) have been examined. It is shown that all these detergents exhibit an ability to stabilize a bilayer organi... | [
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... |
10,003,760 | Transport of ascorbate into guinea pig liver mitochondria. | [
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10,003,761 | The amount of ascorbate associated with guinea pig liver mitochondria was estimated by high-performance liquid chromatography. Incubation of mitochondria with ascorbate revealed a time-dependent and temperature-dependent accumulation of the vitamin. A steady-state level of ascorbate was obtained in the mitochondria aft... | [
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10,003,762 | Core structure, internal osmotic pressure and irreversible structural changes of chromaffin granules during osmometer behaviour. | [
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10,003,763 | In the adrenal medullary cells, catecholamines are stored in and secreted from specialized secretory vesicles, the chromaffin granules. In order to gain some understanding of both functions of chromaffin granules, it is important to characterize their biophysical organization. Using isolated bovine chromaffin granules ... | [
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10,003,764 | 31P-NMR studies on phospholipid structure in membranes of intact, functionally-active, rat liver mitochondria. | [
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10,003,765 | The structure of mixed cholesterol-phospholipid monolayers spread at the air-water interface as probed by interactions with band 3 protein from erythrocyte membranes. | [
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10,003,766 | Solubilized band 3 protein from human erythrocyte membranes (the anion transport protein) interacts strongly and specifically with monolayers of cholesterol spread at the air-water interface whereas, at pH 7-10, it shows only moderate interactions with phospholipid monolayers (Klappauf, E. and Schubert, D. (1979) Hoppe... | [
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0.0204... |
10,003,767 | Interactions of chlorinated hydrocarbon insecticides with membranes. | [
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10,003,768 | Chlorinated hydrocarbon insecticides quench the fluorescence of N-alkyl derivatives of carbazole. We used phospholipids with covalently attached carbazole as probes for the interactions of chlorinated hydrocarbon insecticides with lipid bilayers, the object being to understand better the toxicities of chlorinated hydro... | [
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0.06728... |
10,003,769 | Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties. | [
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0.044... |
10,003,770 | The transmembrane movements of lactate and other monocarboxylate anions in mammalian erythrocytes have been claimed, by virtue of their sensitivity to SH-reagents, to involve a transfer system different from the classical anion system (Deuticke, B., Rickert, I. and Beyer, E. (1978) Biochim. Biophys. Acta 507, 137-155).... | [
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0.0736642... |
10,003,771 | Transport of neutral amino acids by human erythrocytes. | [
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0.0... |
10,003,772 | The transport of several neutral amino acids by human erythrocytes in vitro was studied. The measurements made included steady-state distributions, kinetics of initial rates of uptake, effects of monovalent cations and anions, general mutual inhibitory interactions, kinetics of inhibitions, effluxes, ability to produce... | [
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0.0531... |
10,003,773 | Local anesthetics and divalent cations have the same effect on the headgroups of phosphatidylcholine and phosphatidylethanolamine. | [
0.11070632189512253,
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-0.05652172863483429,
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0.03315695747733116,
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-0.025585109367966652,
0.0690... |
10,003,774 | The effects of the local anesthetic dibucaine on the membrane headgroup conformations of phosphatidylcholine and phosphatidylethanolamine were determined using 2H- and 31P-NMR. The size of the deuterium quadrupole splittings of the two methylene segments of the choline and ethanolamine groups changed dramatically and t... | [
0.03494257107377052,
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0.050281818956136703,
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-0.004014754667878151,
-0.009749266318976879,
0.0... |
10,003,775 | Proton permeability of liposomes from natural phospholipid mixtures. | [
0.023606374859809875,
-0.10390416532754898,
-0.0571555569767952,
-0.010797894559800625,
0.05120483413338661,
0.031035779044032097,
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0.024091510102152824,
0.051789507269859314,
-0.005072486121207476,
0.06093486... |
10,003,776 | A method to determine the proton permeability coefficient of phospholipid membrane with the fluorescent probe pyranine is described. Very high proton permeability coefficients of liposomes from natural extracts are measured with great accuracy. The proton permeability appears to be linearly related to the fluidity of t... | [
0.005800123792141676,
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0.045846790075302124,
-0.03189689293503761,
0.114966... |
10,003,777 | Specific binding sites for D-alpha-tocopherol on human erythrocytes. | [
-0.012057403102517128,
-0.07640910893678665,
-0.04019374027848244,
-0.026904195547103882,
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0.023703591898083687,
0.049575768411159515,
0.03368111327290535,
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0.09190752357244492,
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0.0331026166677475,
-0.030194539576768875,
0.0... |
10,003,778 | Since vitamin E deficiency is associated with increased susceptibility of erythrocytes to hemolysis, we investigated the presence of tocopherol binding sites in human red blood cells. Erythrocytes were found to have specific binding sites for D-alpha-[3H]tocopherol with properties of receptors. Kinetic studies of bindi... | [
0.009631110355257988,
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0.05878458544611931,
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0.013873247429728508,
0.0014179537538439035,
0.05... |
10,003,779 | Action of peptidolipidic antibiotics of the iturin group on erythrocytes. Effect of some lipids on hemolysis. | [
-0.06440728902816772,
-0.0348256379365921,
-0.09094073623418808,
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0.007403710391372442,
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-0.034763745963573456,
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-0.057355523109436035,
0.09... |
10,003,780 | Iturin A, bacillomycin L and bacillomycin L dimethyl ester have a strong lytic activity upon human erythrocytes while iturin C is totally inactive. The hemolytic action of the antibiotics is inhibited by free cholesterol as well as by cholesterol included in mixed liposomes of phosphatidylcholine-cholesterol and to a l... | [
-0.07538047432899475,
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-0.03525445610284805,
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0.012820743024349213,
0.016789380460977554,
0.... |
10,003,781 | The effect of amine structure on complexation with lasalocid in model membrane systems. I. Identification of charged complexes in lipid bilayer membranes. | [
-0.07616370171308517,
-0.10190083086490631,
-0.07716844975948334,
0.017390914261341095,
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0.016397450119256973,
-0.06317023932933807,
-0.05820434167981148,
0.1... |
10,003,782 | The electrical properties of X-537A (lasalocid) doped lipid bilayer membranes were studied in the presence of a series of nine biogenic amines which contain beta-phenylethylamine as the basic structural unit. The ionophore antibiotic was found to form charged complexes within the membrane during the transport of some o... | [
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0.05188838019967079,
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0.... |
10,003,783 | Cell surface of the fish pathogenic bacterium Aeromonas salmonicida. I. Relationship between autoagglutination and the presence of a major cell envelope protein. | [
-0.02828662283718586,
-0.014787301421165466,
-0.048736587166786194,
-0.02008884586393833,
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0.009764761663973331,
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0.... |
10,003,784 | A comparison was made of membrane protein patterns of various Aeromonas salmonicida strains, initially isolated from different habitats with respect to fish species affected, pathological entity, and geographic location of the outbreak of the disease. A major protein with a molecular weight of 54 000 was found in all a... | [
-0.004541667178273201,
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0.04585426673293114,
-0.07339565455913544,
-0.0007276088581420481,
0.1... |
10,003,785 | Cell surface of the fish pathogenic bacterium Aeromonas salmonicida. II. Purification and characterization of a major cell envelope protein related to autoagglutination, adhesion and virulence. | [
-0.04171114042401314,
-0.04253217205405235,
-0.05325182527303696,
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0.008417299017310143,
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0.028225386515259743,
-0.08473709970712662,
-0.03283242881298065,
0.0744... |
10,003,786 | The purification of the major protein of the membrane fraction of an autoagglutinating strain of Aeromonas salmonicida is described. This protein, designated as additional cell envelope protein, is water-insoluble, has a molecular weight of about 54 000 and its amino terminal sequence is H2N-Asp-Val-Leu-Leu. Neither su... | [
-0.04558568075299263,
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0.08852048218250275,
0.03823503851890564,
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0.030165178701281548,
-0.048236969858407974,
-0.0635330080986023,
0.1087884... |
10,003,787 | Divalent cations and chlorpromazine can induce non-bilayer structures in phosphatidic acid-containing model membranes. | [
-0.01026479247957468,
-0.0704919844865799,
-0.04165906086564064,
-0.050390712916851044,
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0.04218945652246475,
0.032483749091625214,
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0.029977459460496902,
-0.024566175416111946,
-0.02176625095307827,
0.005075732246041298,
0.09... |
10,003,788 | (1) The structural organization of aqueous dispersions of 1,2-dioleoylphosphatidic acid has been investigated by freeze-fracture electron microscopy in relation to variations in pH, divalent cations and the local anaesthetic chlorpromazine. (2) In the pH range 4--8 in the presence of 100 mM Na+, dioleoylphosphatidic ac... | [
-0.007882424630224705,
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0.01267105620354414,
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0.08532027155160904,
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0.06195392832159996,
-0.03773857280611992,
-0.037487633526325226,
0.07869128882884979,
0.0183968... |
10,003,789 | Cross-linking studies of the protein topography of rat liver microsomes. | [
-0.002995433984324336,
-0.08181106299161911,
-0.01509115844964981,
-0.01088700070977211,
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0.001232138485647738,
0.06315109133720398,
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-0.01264313142746687,
0.024660412222146988,
-0.016624055802822113,
-0.01487747672945261,
0... |
10,003,790 | A cleavable cross-linking reagent, dithiobis(succinimidyl propionate), DSP, was used to study the topography of the proteins in the endoplasmic reticulum membrane of rat liver. Reaction of untreated (control), phenobarbital- or 3-methylcholanthrene-induced microsomes with 0.5 mM DSP for 30 min at 0 degrees C resulted i... | [
-0.04202387481927872,
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0.0016495404997840524,
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0.13223738968372345,
0.03473582863807678,
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0.010426933877170086,
-0.048617225140333176,
-0.07585470378398895,
0.... |
10,003,791 | Structural changes in alkaline-treated postsynaptic membranes from Torpedo marmorata are not due to lipid hydrolysis. | [
-0.041954439133405685,
-0.07237385213375092,
-0.015065553598105907,
0.009976927191019058,
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0.0469958670437336,
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0.03901424631476402,
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-0.09134946018457413,
0... |
10,003,792 | The removal of the 43 kDa peptide from postsynaptic membranes from the electric organ of Torpedo by alkaline treatment (pH 11) or by lithium diiodosalicylate at pH 8 results in similar ultrastructural changes that cannot be produced by the action of porcine pancreatic phospholipase A2 or lysophosphatidylcholine. Thin-l... | [
0.0036350705195218325,
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-0.05845120921730995,
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0.054648563265800476,
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0.004380899481475353,
0.05510519817471504,
-0.0003458374412730336,
-0.06939244270324707,
0.06... |
10,003,793 | Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes. | [
-0.049830660223960876,
-0.09061235934495926,
0.03086298517882824,
-0.06763523072004318,
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0.04849619045853615,
0.050311651080846786,
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0.011586558073759079,
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0.035209085792303085,
0.037990719079971313,
0.0... |
10,003,794 | Lowering extravesicular pH stimulated Na+-dependent citrate transport in renal brush border membrane vesicles: e.g., at pHout = 5.5, the initial rate of citrate uptake was increased 10-fold compared to parallel control experiments at pH 7.5. The same experimental conditions had little effect on succinate uptake. The in... | [
0.0188053697347641,
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0.05280851945281029,
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0.040345314890146255,
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0.04344376176595688,
0.02131235972046852,
0.012123707681894302,
-0.00017213971295859665,
0.06604226678609848,
0.060... |
10,003,795 | The effect of amphotericin B on the permeability of lipid bilayers to divalent trace metals. | [
-0.015615233220160007,
-0.08981795608997345,
0.004052067641168833,
0.0353788360953331,
0.005671951454132795,
0.006684488616883755,
0.1121237725019455,
0.04168221727013588,
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-0.04817531257867813,
-0.05372081324458122,
-0.07716462761163712,
-0.008593427017331123,
0.0539... |
10,003,796 | In this study amphotericin B released the divalent trace metals Zn2+, Co2+, Cu2+, Ni2+, Mn2+, Fe2+, Cd2+ and Pb2+ from multilamellar liposomes containing cholesterol. This observation is consistent with amphotericin B channels being permeable to these metals, and it is proposed, therefore, that the antibiotic may be us... | [
-0.02787167578935623,
-0.06907248497009277,
-0.07649587094783783,
0.012538366951048374,
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0.00929245911538601,
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-0.019972840324044228,
-0.05721587687730789,
0.041447632014751434,
0.011... |
10,003,797 | Structural features of fibrinogen associated with binding to chelated zinc. | [
-0.10348767787218094,
-0.054949499666690826,
-0.01232336275279522,
0.016454987227916718,
0.08985505998134613,
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0.056085005402565,
0.0401674248278141,
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0.02550956979393959,
-0.020030340179800987,
-0.03949733451008797,
0.018561122938990593,
0.040108... |
10,003,798 | Fibrinogen absorbed to zinc chelate columns at pH 7.8 and was eluted sharply with a pK of 5.8 indicative of the involvement of a histidine residue. The binding was unaffected by high concentrations of calcium or zinc. Fibrinogen degradation products X and Y also bound to zinc chelate columns. On passage of fibrinogen f... | [
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0.1025790199637413,
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0.041200220584869385,
-0.01732528768479824,
0.008244086056947708,
0.012695944868028164,
0.0674... |
10,003,799 | Selective arylation of cysteine-237 of rabbit muscle aldolase with 4-chloro-7-nitrobenzofurazan. | [
-0.012008233927190304,
-0.030937183648347855,
-0.024064939469099045,
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0.037584077566862106,
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-0.008045751601457596,
0.012043231166899204,
0.03932320699095726,
0.02556033805012703,
... |
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