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10,003,900 | Conformations of model peptides in membrane-mimetic environments. | [
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10,003,901 | The influence of a membrane environment on the conformational energetics of a polypeptide chain has been investigated through studies of model peptides in a variety of membrane-mimetic media. Nuclear magnetic resonance (NMR) and circular dichroism (CD) data have been obtained for the peptides in bulk hydrophobic solven... | [
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10,003,902 | Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. | [
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10,003,903 | The cytotoxic peptide from honeybee venom, melittin, and a synthetic peptide analogue of it lyse human erythrocytes in a biphasic process. The kinetics of the lysis in 0.30 M sucrose, 0.01 M sodium phosphate, pH 7.30 at 4 degrees C were investigated. Our results show that melittin rapidly binds to the outer surface of ... | [
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10,003,904 | Comparative effects of melittin and its hydrophobic and hydrophilic fragments on bilayer organization by Raman spectroscopy. | [
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10,003,905 | For bilayer systems consisting of 1,2-dimyristoyl phosphatidylcholine (DMPC) incubated with melittin, a polypeptide capable of integrating itself within the membrane, temperature profiles derived from Raman spectroscopic data indicate the existence of an immobilized lipid annulus surrounding the polypeptide. In particu... | [
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10,003,906 | The structure of melittin in the form I crystals and its implication for melittin's lytic and surface activities. | [
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10,003,907 | Melittin from bee venom is water-soluble, yet integrates into membranes and lyses cells. Each melittin chain consists of 26 amino acid residues and in aqueous salt solutions it exists as a tetramer. We have determined the molecular structure of the tetramer in two crystal forms grown from concentrated salt solutions. I... | [
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10,003,908 | Structure and function of an acetylcholine receptor. | [
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10,003,909 | Structural analysis of an acetylcholine receptor from Torpedo californica leads to a three-dimensional model in which a "monomeric" receptor is shown to contain subunits arranged around a central ionophoretic channel, which in turn traverses the entire 110 A length of the molecule. The receptor extends approximately 15... | [
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10,003,910 | Influence of ionic strength on the dichroism properties of polynucleosomal fibers. | [
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10,003,911 | Conformations of cyclic peptide/calcium complexes in solution. | [
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10,003,912 | Interactions of DNA with divalent metal ions. I. 31P-NMR studies. | [
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10,003,913 | Interactions of DNA with divalent metal ions. II. Proton relaxation enhancement studies. | [
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10,003,914 | Interactions of DNA with divalent metal ions. III. Extent of metal binding: experiment and theory. | [
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10,003,915 | Anomalous temperature dependence on frictional coefficients: diffusion and sedimentation measurement of low-density lipoproteins, albumin, and polystyrene latex. | [
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10,003,916 | Intramolecular low-frequency vibrations in lysozyme by neutron time-of-flight spectroscopy. | [
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10,003,917 | Fluorescent-labeled crosslinks in collagen: pyrenebutyrylhydrazine. | [
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10,003,918 | Bone marrow cell count per cubic millimeter bone marrow: a new parameter for quantitating therapy-induced cytoreduction in acute leukemia. | [
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10,003,919 | A new technique is introduced for determining the number of bone marrow cells per cubic millimeter marrow, providing an accurate and objective means for quantitating therapy-induced cytoreduction. The method requires a correction for admixed peripheral blood in bone marrow aspirates to measure the fraction of remaining... | [
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10,003,920 | A liquid culture system for murine megakaryocyte progenitor cells. | [
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10,003,921 | A liquid culture system is described for murine megakaryocyte progenitor cells (CFU-M) in the presence of pokeweed-mitogen-stimulated spleen-cell conditioned medium. There were dose-related responses between the number of CFU-M developed and the number of cells cultured and the dosage of conditioned medium in this liqu... | [
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10,003,922 | Mechanism of dexamethasone inhibition of chemotactic factor induced granulocyte aggregation. | [
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10,003,923 | The reaction of FMLP with granulocytes causes aggregation and degranulation and enhances adherence to endothelium. To evaluate whether prevention of granule extrusion could impair these granulocyte activities, granulocytes were treated with either dexamethasone or hydrocortisone prior to treatment with FMLP. Dexamethas... | [
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10,003,924 | Large granular lymphocytes in human peripheral blood: ultrastructural and cytochemical characterization of the granules. | [
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10,003,925 | Large granular lymphocytes (LGL) are defined as nonadherent mononuclear cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and cytotoxic functions (NK or ADCC activities). In the present study, the granules of LGL isolated from human peripheral blood have been analyzed by enzyme cyto... | [
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10,003,926 | Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man. | [
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10,003,927 | We studied two brothers (J.R. and M.R.) with the cobalamin D variant of congenital methylmalonic aciduria-homocystinuria, whose previously reported lack of megaloblastic anemia conflicted with current concepts of cobalamin's role in DNA synthesis and the "methyltetrahydrofolate (MTHF) trap" hypothesis. Both subjects we... | [
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10,003,928 | Experimental candidiasis in neutropenic dogs: tissue burden of infection and granulocyte transfusion effects. | [
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10,003,929 | The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis. | [
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10,003,930 | We have evaluated the fibrinogen/fibrin fragment E antigen assay as a diagnostic test in patients with clinically suspected venous thrombosis by comparing the results of this assay with venography in 272 patients. The result of the fragment E antigen assay was elevated in 79 of 80 patients with positive venograms for r... | [
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10,003,931 | Effect of transfused reticulocytes on iron exchange. | [
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10,003,932 | A animal model was developed whereby reticulocyte-rich blood was introduced into normal rats by exchange transfusion. Measurements of plasma iron turnover was made at similar plasma iron concentrations before and after exchange transfusions. High reticulocyte blood obtained from animals rendered iron deficient by diet ... | [
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10,003,933 | Monoclonal antibodies that detect differentiation surface antigens on human myelomonocytic cells. | [
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10,003,934 | We describe here the production and characterization of several new monoclonal antibodies that recognize differentiation antigens present on human cells of the myelomonocytic lineage. The lineage and the stage specificities of our reagents (myeloid-, monocytic-, and myelomonocytic-specific) were determined on the basis... | [
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10,003,935 | Abnormal glucocorticoid receptors in acute leukemia cells. | [
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10,003,936 | In normal tissues, 3H-triamcinolone acetonide (3H-TA) labeled glucocorticoid receptors can be resolved into 2 components by DEAE chromatography: peak I elutes at 0.04 M salt and peak II at 0.22 M salt. By glycerol gradient centrifugation, peak I is 3.5S and peak II is 8.5S. Peak I binds to DNA, while peak II does not. ... | [
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0.003... |
10,003,937 | Effect of cell shape on extravascular hemolysis. | [
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... |
10,003,938 | Severe-glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with chronic hemolytic anemia, granulocyte dysfunction, and increased susceptibility to infections: description of a new molecular variant (G6PD Barcelona). | [
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10,003,939 | Molecular, kinetic, and functional studies were carried out on erythrocytes and leukocytes in a Spanish male with G6PD deficiency, congenital nonspherocytic hemolytic anemia (CNSHA), and increased susceptibility to infections. G6PD activity was absent in patient's red cells and was about 2% of normal in leukocytes. Mol... | [
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10,003,940 | Assessment of red cell sodium transport in essential hypertension. | [
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10,003,941 | Abnormal erythrocyte Na+ transport has been reported in patients with essential hypertension and some first-degree relatives. The two major techniques now employed for estimating Na+ transport--Na+/Li+ countertransport and Na+/K+ cotransport--are rather intricate and time consuming. Furthermore, the precise nature of t... | [
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10,003,942 | Erythroid progenitors in polycythemia vera: demonstration of their hypersensitivity to erythropoietin using serum free cultures. | [
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10,003,943 | A system for generating a variable mechanical impedance and its use in an investigation of the electromechanical properties of the B71 audiometric bone vibrator. | [
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10,003,944 | A method of presenting a bone vibrator with a variable mechanical load is described. Reciprocal relationships between electrical and mechanical properties of the B71 vibrator have been investigated and it is concluded that the vibrator behaves as a linear, reversible electrodynamic system. The mechanical impedance of t... | [
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0... |
10,003,945 | Different patterns of harmonics in frequency-following responses. | [
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10,003,946 | Preliminary studies (Krogh et al., 1977) indicated pronounced intersubject differences with respect to harmonic distortion in the frequency-following responses (FFRs) elicited by high intensity, low frequency stimuli and recorded by means of surface electrodes from man. In the present investigation it was confirmed tha... | [
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10,003,947 | Problems encountered at work by people with severe acquired hearing loss. | [
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10,003,948 | A structured questionnaire concerning problems encountered at work was administered to 88 adults of employment age suffering from acquired sensorineural hearing loss (60 dB +). While respondents were not likely to be out of work by virtue of their hearing loss, they found it difficult to cope at work for a variety of r... | [
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10,003,949 | Frequency resolution and hearing loss. | [
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... |
10,003,950 | Future scientific and diagnostic interest in frequency resolution requires an evaluation of the different methods that are available to measure it. We compared three methods: (1) pure-tone thresholds in broadband noise, (2) pure-tone thresholds in the presence of a fixed pure-tone masker and (3) psychoacoustical tuning... | [
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10,003,951 | Loudness adaptation: real or illusory. | [
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10,003,952 | There is general agreement that, except at low sensation levels, the loudness of a continuous pure tone does not appear to change with time. By contrast, using a simultaneous dichotic loudness balancing procedure (SDLB) a substantial fall in loudness can be revealed. As a result it has been held that the latter does no... | [
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10,003,953 | Calcification in pulmonary metastases. | [
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10,003,954 | A large variety of neoplasms can produce calcified lung metastases. Three unusual examples are presented and the relevant literature is reviewed. Each case involves a neoplasm not previously reported to produce calcified lung metastases: malignant mesenchymoma, fibrosarcoma of the breast, and medullary carcinoma of the... | [
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0.0415... |
10,003,955 | The ultrasound diagnosis of emphysematous cholecystitis. | [
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0.0610... |
10,003,956 | Regional evaluation of the left ventricular wall motion by radionuclide ventriculography. | [
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0.0611... |
10,003,957 | ECG gated radionuclide ventriculography was performed in 85 patients with heart disease. From the analysis of time activity curves of each pixel, sets of parametric scans were displayed. Of 496 parametric scans, 192 were normal and 304 showed wall motion abnormalities. There was good correlation between the individual ... | [
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0.0... |
10,003,958 | Quantitative measurement of activity in small sources containing medium energy radionuclide: comparison of the gamma camera and the rectilinear scanner. | [
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0.03670751... |
10,003,959 | The response of a gamma camera and a rectilinear scanner to small sources containing 131I was assessed from the point of view of thier suitability for measuring the activity of a source, as opposed to their capacity to produce well-resolved images. The influence of the size of the area over which counts were integrated... | [
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10,003,960 | Mechanisms of distribution of gallium 67 in mouse tumour hosts. | [
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10,003,961 | In several mouse tumour models iron given parenterally not only inhibited the transport of 67Ga by plasma transferrin but also accelerated the binding of 67Ga in tumour tissue, particularly during the first hour after 67Ga injection. By 30 min, the tumour had already attained a high concentration though the 67Ga accumu... | [
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10,003,962 | A light torch for the transillumination of female breast tissues. | [
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0.028... |
10,003,963 | The breast can be examined by transillumination with white light. The tissues transmit more light in te red and infrared part of the spectrum than in the blue. Images of the breast are normally recorded on colour infrared film. An alternative to photography is the use of a television camera sensitive to the near infrar... | [
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0.0... |
10,003,964 | The effects of negative pions on spermatogonial survival in the mouse. | [
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0.069934... |
10,003,965 | A study of the radiation effects of pi-mesons on the testes of the mouse has been carried out using the pion beam at the SRC Rutherford Laboratory. The cell killing effects on type B and intermediate spermatogonia have been assessed and compared with the effects of 20-0 kVp X rays, delivered at the same dose rate. It w... | [
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0.082... |
10,003,966 | A comparison of thermal enhancement ratios for fast neutron and x irradiation of two normal tissues in rodents. | [
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0.092885... |
10,003,967 | The effects of a hyperthermal treatment of one hour on radiation damage to baby rat cartilage and mouse intestine were compared for 250 kVp X irradiation and cyclotron-produced neutron irradiation (mean energy of about 7.5 MeV). Heat, in the range 41.0 degrees C-43.0 degrees C, caused no observable gross tissue injury ... | [
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0.093408... |
10,003,968 | A simple tissue-like ultrasound phantom material. | [
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... |
10,003,969 | Castleman's giant lymph node hyperplasia. | [
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10,003,970 | Sonographic diagnosis of calcified thrombus of the inferior vena cava. | [
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0.09... |
10,003,971 | Neural arch dysplasia of the sixth cervical vertebra associated with spinal cord compression. | [
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10,003,972 | The ultrasonographic appearance of a trichobezoar. | [
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0.061... |
10,003,973 | Does psychiatric illness affect the recurrence rate of genital herpes? | [
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0.01821412332355976,
0.07704... |
10,003,974 | The progress of 58 patients with first attacks of genital herpes was monitored for up to 30 weeks. The effects of sex (gender), age, social class, and non-psychotic psychiatric illness (as measured by the "general health questionnaire," GHQ) on the recurrence rate of herpes was studied. The recurrence rates, measured b... | [
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0.016950784251093864,
0.01906... |
10,003,975 | Cell-mediated immunity in HBeAg-positive homosexuals with chronic liver disease. | [
0.022402454167604446,
0.06982754170894623,
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10,003,976 | Chronic liver disease developing after infection with the hepatitis B virus may be due to impairment of cell-mediated immunity (CMI). In a study of CMI by the lymphocyte transformation test to two mitogens and hepatitis B surface antigen (HBsAg) the response to the mitogens, phytohemagglutinin (PHA) and purified protei... | [
0.003204584587365389,
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0.01481939572840929,
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10,003,977 | Penicillin epileptogenesis in the rat: diffusion and the differential laminar sensitivity of the cortex cerebri. | [
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0.15... |
10,003,978 | When penicillin is applied electrophoretically from a fluid-filled microelectrode into the substance of the somatosensory cortex of the rat under urethane anaesthesia, the latent period for production of interictal epileptic spikes is least when the electrode lies 0.7 mm below the cortical surface. With low electropho... | [
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0.1384... |
10,003,979 | Behavioral correlates of sexual differentiation in the zebra finch song system. | [
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-... |
10,003,980 | The capacity for song is masculinized in female zebra finches by exposure to 17 beta-estradiol at hatching, and requires continual exposure to androgen for its behavioral expression in the adult. The stereotypy of the song developed by estrogenized females can be as good as that of male song. The sexual dimorphism in b... | [
0.0468314103782177,
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10,003,981 | Electrophysiological evidence for the topographical arrangement of taste and tactile neurons in the facial lobe of the channel catfish. | [
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0.011... |
10,003,982 | Neural responses in the facial lobe of th channel catfish to chemical and mechanical stimulation of the external skin surface were studied electrophysiologically. Taste and tactile neurons in the lobe were organized in a somatotopic manner, which confirms the anatomical reports of the facial lobe in the bullhead catfis... | [
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0.0213... |
10,003,983 | The termination of geniculocortical fibres in area 17 of the visual cortex in the macaque monkey. | [
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0.07883381098508835,
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0.02170... |
10,003,984 | The termination of geniculocortical fibres within the different subdivisions of lamina IV in area 17 of the visual cortex of the monkey has been studied quantitatively with the electron microscope. In lamina IVC alpha the axon terminals of fibres coming from the magnocellular layers of the lateral geniculate nucleus (L... | [
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0.06902056932449341,
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0... |
10,003,985 | Physiological properties of expanded ipsilateral retinocollicular projection in neonatally enucleated albino rats. | [
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0.03977090120315552,
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0.0420... |
10,003,986 | The olfactory bulb mitral cell responses in the gecko as studied by intracellular recording. | [
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0... |
10,003,987 | The mitral cell odor-induced intracellular responses and the accompanying membrane resistance changes were studied in the gecko olfactory bulb. The mitral cells responded to odor either with depolarization or with hyperpolarization. The depolarization responses with hyperpolarization. The depolarization responses were ... | [
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10,003,988 | Reticular neuron activities associated with locomotion in thalamic cats. | [
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0.009360571391880512,
0.0421740... |
10,003,989 | Unit discharges of the reticular neurons and EMGs of extensors and flexors were recorded in the 4 limbs of thalamic cats during stepping on a motor-driven treadmill to study the functional role of the spino-bulbo-spinal (SBS) reflex in locomotion. (1) Reticular neurons showed alterations of increased or decreased disch... | [
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0.03326663374900818,
0.0631442591547966,
0.06501952558755875,
0.065970465540... |
10,003,990 | Estrogen receptors in the turtle brain. | [
0.02034742385149002,
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0.01618906483054161,
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-0.01618... |
10,003,991 | Estrogen binding activity in the CNS of the freshwater turtle, Chrysemys picta, was investigated using DNA-cellulose affinity chromatography. An estrogen binding component (EBC) with the characteristics of an estrogen receptor species was demonstrated in the brain cytosol extracts from both sexes. This EBC exhibited hi... | [
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0.060518767684698105,
0.03097345679998398,
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10,003,992 | Somatotopic organization of SI corticotectal projections in rats. | [
0.11029528081417084,
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0.0758867859840393,
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0.02698... |
10,003,993 | The somatotopic organization of somatosensory (SI) cortical projections to the deep layers of the superior colliculus (SC) in rats was examined using neurophysiological micromapping methods. Electrical stimulation of SI produced SC unit responses at the same depths as did peripheral tactile stimulation, in SC laminae I... | [
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0.0098... |
10,003,994 | Spatial properties of nociceptor sensitization following heat injury of the skin. | [
0.06864567846059799,
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0.009379342198371887,
0.10305664... |
10,003,995 | A brief noxious heat stimulus applied to half of the receptive field of each cutaneous nociceptor resulted in most cases in the enhanced responsiveness of that half to subsequent heat stimuli (sensitization). No change in responsiveness to heat was observed in the other half of the receptive field, indicating that the ... | [
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0.02106168121099472,
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0.1160... |
10,003,996 | Functional properties of area 19 as compared to area 17 of the cat. | [
0.10050560534000397,
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0.016845710575580597,
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0.09... |
10,003,997 | Out of a total of 139 area 19 cells, 87 were examined quantitatively for their responses to stimuli moving at a wide range of velocities. The results were compared with those obtained on a sample of 106 area 17 cells (out of a total of 172) tested in the same way. It was found that both areas 19 and 17 prefer slow stim... | [
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0.004926376044750214,
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10,003,998 | Receptive field structure of area 19 as compared to area 17 of the cat. | [
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0.09096... |
10,003,999 | A total of 139 cells from area 19 along with a comparison sample of 172 cells from area 17 were classified using a system proposed by Orban and Kennedy, following Henry and consisting of 4 basic cell 'families', namely S, C, A and B, each having an end-stopped member: HS, HC, HA and HB. The two basic parameters separat... | [
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0.0368167981505394,
0.017772957682609558,
-0.055678434669971466,
0.01015499234199524,
-0.02... |
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