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10,003,800 | At pH 7.0 and 25 degrees C, NBF-Cl (4-chloro-7-nitrobenzofurazan) reacts rapidly with rabbit muscle aldolase (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13) to yield a product with an absorption maximum at 402 nm, which is shifted to 422 nm upon acid denaturation. The reaction involves ary... | [
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10,003,801 | Modification of the essential amino acids of human pancreatic carboxylic-ester hydrolase. | [
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10,003,802 | Chemical modification of human pancreatic carboxylic-ester hydrolase (EC 3.1.1.1) were performed using organophosphorus compounds, ethoxyformic anhydride and Woodward's K reagent. It has been shown that: (1) the inhibition of the enzyme activity by organophosphorus compounds is due to the phosphorylation of only one al... | [
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10,003,803 | Catalytic properties of modified human pancreatic carboxylic-ester hydrolase. | [
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10,003,804 | Human pancreatic carboxylic-ester hydrolase (EC 3.1.1.1) modified by specific reagents (diisopropyl phosphorofluoridate, diethyl p-nitrophenyl phosphate, Woodward's K reagent and ethoxyformic anhydride) was studied for its activity. The three residues probably implicated in the active site acting on soluble substrate a... | [
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10,003,805 | Stability and inhibition of Aspergillus and Rhizopus lipases. | [
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10,003,806 | A lipase (triacylglyceral aclhydrolase, EC 3.1.1.3) secreted by Aspergillus contains two chains each of molecular weight 25000, with 12 mannose, two galactose and two N-acetylglucosamine residues per chain. The average hydrophobicity is close to the mean fov globular proteins. Thermal denaturation was biphasic when fol... | [
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10,003,807 | Tryptophan fluorescence of human hemoglobin. II. Effect of inositol hexaphosphate on the T-R transition. | [
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10,003,808 | Fluorescence spectra of tryptophan residues of human hemoglobin in the absence and presence of inositol hexaphosphate were measured at room temperature. The tryptophan fluorescence intensity of deoxy HbA was observed to decrease in accordance with the binding with inositol hexaphosphate. The fluorescence intensity of H... | [
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10,003,809 | Assembly of formyltetrahydrofolate synthetase monomers. Kinetic evidence for a temperature-induced conformational change. | [
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10,003,810 | The assembly of Clostridium acidi-urici formyltetrahydrofolate synthetase (formate: tetrahydrofolate ligase (ADP-forming), EC 6.3.4.3) monomers induced by low concentrations of CsCl to form the catalytically active tetramer shows a pronounced lag phase in the time-course progress curve. Preincubation of the monomer for... | [
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10,003,811 | Sulfhydryl groups of native myosin and of the myosin heavy chains from Physarum polycephalum compared to vertebrate skeletal, smooth, and non-muscle myosins. | [
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10,003,812 | Although a previously reported analysis of Physarum myosin detected no cysteine residues in the molecule, the myosin ATPase activity was inhibited by p-chloromercuribenzoate. We have re-examined this apparently contradictory finding. We found highly purified plasmodial myosin to be very sensitive to N-ethylmaleimide in... | [
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10,003,813 | An affinity label for the anion binding site in ovotransferrin. Implications for iron release to reticulocytes. | [
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10,003,814 | Bromopyruvate has been found to be an affinity label for the anion binding site in ovotransferrin. Spectral and radioactive labeling studies indicate that the bromopyruvate first forms a reversible ternary complex with ovotransferrin and iron and then reacts to yield the covalently bound product. This derivative is par... | [
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10,003,815 | Essential arginine residues in the pyridine nucleotide binding sites of glutathione reductase. | [
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10,003,816 | Glutathione reductase (NAD(P)H: oxidized-glutathione oxidoreductase, EC 1.6.4.2) from human erythrocytes as well as from other sources was inactivated irreversibly by the arginine modifying reagents 2,3-butanedione, 1,2-cyclohexanedione and phenylglyoxal. The inactivation caused by these reagents increased with time an... | [
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10,003,817 | The isolation, purification, and properties of a ribonuclease (Mr 18 000) from human uremic serum, and its relation to the human urinary ribonuclease (Mr 33 000). I. Isolation of the low molecular weight ribonuclease. | [
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10,003,818 | The isolation, purification, and properties of a ribonuclease (Mr 18 000) from human uremic serum, and its relation to the human urinary ribonuclease (Mr 33 000). II. Properties of the enzymes. | [
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10,003,819 | A low molecular weight ribonuclease (Mr 18 000) isolated and purified from human uremic serum was found to have similar properties to the high molecular weight ribonuclease (Mr 33 000) isolated from human urine. A detailed comparative study of both enzymes was undertaken to investigate the relationship between them. It... | [
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10,003,820 | Evidence for cooperative effects in human liver arginase. | [
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10,003,821 | The reaction kinetics of human liver arginase (L-arginine amidinohydrolase, EC 3.5.3.1) in terms of arginine concentration is strikingly altered by varying the pH. Lowering the pH from the optimum (9.5) toward a more physiological value (7.5) there is a transition from hyperbolic to sigmoidal kinetics. The cooperative ... | [
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10,003,822 | Iron content and molecular weight of uteroferrin and a comparison of its iron and copper forms. | [
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10,003,823 | The molecular weight of the purple, iron-containing glycoprotein uteroferrin has been determined to be 35140 +/- 1610 by sedimentation equilibrium centrifugation. This is consistent with measurements carried out by other procedures. The dry weight of a solution of uteroferrin with an absorption of 1.00 cm -1 at 280 nm ... | [
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10,003,824 | Drug-induced oxidation and precipitation of hemoglobins A, S and C. | [
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10,003,825 | Analysis of optical absorption spectra of drug-hemoglobin reaction mixtures show that oxidation of oxyhemoglobins A, S and C by menadione and acetylphenylhydrazine and the consequent formation of methemoglobin, hemichromes and 'choleglobin' proceed at identical rates for all three hemoglobins. Nevertheless, precipitate... | [
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10,003,826 | A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain. | [
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10,003,827 | Hemoglobin Ogi, in which an arginine is substituted for a leucine residue at position 34 of the alpha-chain, was detected in a Japanese family. Although slightly increased oxygen affinity is associated with this amino acid substitution in the alpha 1 beta 1 contact, it is without obvious deleterious effect on the hemat... | [
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10,003,828 | Studies on carbohydrate binding to a lectin purified from Streptomyces sp. | [
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10,003,829 | The anti-B specific lectin produced by Streptomyces sp. was shown to have two carbohydrate-binding sites with binding constants of 8.3 . 10(3) M-1 (15 degrees C) and 2.2 . 10(3) M-1 (4 degrees C) for L-rhamnose and D-galactose, respectively, calculated according to Scatchard plots. The binding of specific sugars to the... | [
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10,003,830 | Comparative study of the conformational features of rat immunoglobulin G subclasses by circular dichroism. | [
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10,003,831 | Four subclasses of rat immunoglobulin G and some of their fragments were studied by circular dichroism. These studies were carried out in different conditions in order to determine whether conformational differences exist between each subclass. The results showed that in their native state the subclasses cannot be dist... | [
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10,003,832 | Lipid composition of tracheobronchial secretions from normal individuals and patients with cystic fibrosis. | [
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10,003,833 | The lipid composition of tracheobronchial secretions from normal individuals and patients with cystic fibrosis was investigated. Lipids were extracted from he dialyzed and lyophilized samples, and fractionated on silicic acid columns into neutral lipids, glycolipids and phospholipids. The lipids contained each fraction... | [
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10,003,834 | Studies on the in vivo synthesis of triacylglycerol in mouse liver. | [
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10,003,835 | The in vivo biosynthesis of hepatic glycerolipids was examined by studying the incorporation of [2-3H] glycerol into triacylglycerol in the mouse. The isotope was administered by rapid injection into the portal vein. The incorporation of glycerol was linear for about 1 min and maximal rates were seen in the presence of... | [
0.07258038967847824,
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-0... |
10,003,836 | Biosynthesis of platelet-activating factor. I. Evidence for an acetyl-transferase activity in murine macrophages. | [
-0.04033944010734558,
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-0.030808232724666595,
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0.01... |
10,003,837 | Platelet-activating factor (PAF-acether; 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is released from murine peritoneal adherent cells by inflammatory and non-inflammatory stimuli. We have found, in extracts from these cells, an enzyme activity that synthesizes. PAF-acether from synthetic lyso-PAF-acether by tr... | [
-0.046551644802093506,
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0.05775897204875946,
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0.000767... |
10,003,838 | Biosynthesis of dolichol and cholesterol during embryonic development of the chicken. | [
-0.04690200462937355,
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-0.08959916234016418,
0.012681757099926472,
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-0.03... |
10,003,839 | The polyisoprenol dolichol, in its phosphorylated form, serves as the lipid intermediate in N-linked glycoprotein synthesis, and shares the portion of its biosynthetic pathway with cholesterol. The synthesis of dolichol and cholesterol was followed over the course of development by incubating chicken embryos with [3H] ... | [
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-0.0632382407784462,
-0.03667079... |
10,003,840 | The turnover of molecular species of phosphatidylinositol in Ehrlich ascites tumor cells. | [
-0.03991949185729027,
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10,003,841 | It has been shown previously the 32Pi is incorporated into phosphatidylinositol 30 times faster than into the other phospholipids classes in Ehrlich ascites tumor cells, whereas [1-14C] glycerol is incorporated at almost the same rate (Waku, K., Nakazawa, Y. and MOri, W. (1976) J. Biochem. 79, 407-411). It was therefor... | [
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10,003,842 | Relative acylglycerol acyltransferase activities in homogenates of enzymically dispersed rat jejunal villus and crypt cells. | [
-0.04020320624113083,
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0.04659681394696236,
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0.0973973274230957,
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0.026421310380101204,
0.0322... |
10,003,843 | The relative acyltransferase activities were compared in homogenates of rat jejunal villus and crypt cells isolated by differential scraping and hyaluronidase dispersion. The contributions of the monoacylglycerol and phosphatidic acid pathways to the higher acylglycerol and phospholipid biosynthesis were assessed using... | [
-0.07340923696756363,
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0.003196560777723789,
-0.003... |
10,003,844 | Tissue sites of catabolism of rat and human low density lipoproteins in rats. | [
0.06487122923135757,
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10,003,845 | We have determined the sites of degradation of low density lipoprotein in rats using covalently linked [14C] sucrose as tracer. On degradation, 14C is trapped intracellularly as a cumulative measure of the amount of protein catabolized by each tissue. [14C] Sucrose-labeled rat low density lipoprotein (d 1.02-1.05 g/ml)... | [
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0.001044692238792777,
0.06478870660066605,
-0.04340743646025658,
0.061... |
10,003,846 | Increased hepatitic cholesterol production due to liver hypertrophy in rat experimental nephrosis. | [
0.056843388825654984,
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10,003,847 | Control and nephrotic rats were compared as to the liver contents of cholesterol, phospholipid and the activity of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Whole liver homogenates as well as endoplasmic reticulum membrane samples showed increased free cholesterol and phospholipid mass in the nephroti... | [
0.003828768851235509,
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10,003,848 | Lysolecithin acyltransferase and alveolar phosphatidylcholine palmitate in experimental acute alveolar injury in the dog lung. | [
0.0009910744847729802,
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0.114043... |
10,003,849 | Lysolecithin acyltransferase (EC 2.3.1.23) activities in lung homogenates and in subcellular fractions, and fatty acid composition of phosphatidylcholine (PC) in lung lavage were studied in dogs with acute alveolar injury induced by N-nitroso-N-methylurethane. The specific activity in the microsomal fraction was 10 and... | [
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0.008195675909519196,
0.020057998597621918,
0.0900... |
10,003,850 | Effects of lipid peroxidation on prostaglandin synthesis in rabbit kidney medulla slices. | [
-0.00046607392141595483,
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-0.... |
10,003,851 | Ascorbic acid and Fe2+ had a more powerful stimulatory effect on the lipid peroxidation of rabbit kidney medullar slices in 0.15 M KCl/0.02 M Tris-HCl buffer than in Krebs-Henseleit buffer. The lipid peroxidation induced by ascorbic acid and Fe2+ enhanced the release of unsaturated fatty acids from tissue lipids, but i... | [
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0.03697912395000458,
-0.041265424340963364,
-0.075256... |
10,003,852 | Increased cholesterol esterification in rat liver microsomes in purified non-specific phospholipid transfer protein. | [
-0.015156704001128674,
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0.01474788784980774,
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0.02309... |
10,003,853 | The effect of the non-specific phospholipid transfer protein purified from rat liver on the activity of acyl-CoA:cholesterol acyltransferase (EC 2.3.1.26) in rat liver microsomes was studied. The activity of cholesterol acyltransferase was measured from the rate of incorporation of [1-14C] oleoyl-CoA into cholesteryl o... | [
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0.04082883149385452,
0.030908294022083282,
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0.04279511049389839,
0.007121221628040075,
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0.037690... |
10,003,854 | Regulation of mouse hepatic ATP-citrate lyase activity by dietary fat. Evidence for the presence of inactive enzyme. | [
-0.016585715115070343,
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0.00975553598254919,
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-0.020... |
10,003,855 | The induction of ATP-citrate lyase activity in mouse liver dietary carbohydrate (glucose) in markedly reduced by including in the diet a source of polyunsaturated fatty acids. Within 72 h after changing from a standard mouse chow diet to a high carbohydrate diet containing 15% (W/W) of hydrogenated cottonseed oil (as a... | [
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0.025178328156471252,
0.009239384904503822,
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10,003,856 | Effects of local anesthetics and related compounds on the endocytosis and catabolism of asialo-glycoproteins in isolated hepatocytes. | [
0.06802105158567429,
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0.03810979798436165,
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0.052124... |
10,003,857 | The effects of local anesthetics, including procaine and dibucaine, and some related amine compounds, such as dansyl-cadaverine, were studied with respect to their effects on the uptake and degradation of asialo-glycoproteins in isolated hepatocytes. 0.5 mM of either dibucaine or dansyl-cadaverine reduced the rates of ... | [
0.07114074379205704,
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0.051729850471019745,
0.011250773444771767,
0.082816... |
10,003,858 | Role of glucose metabolism in acid formation by isolated gastric glands. | [
0.05587092787027359,
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0.030948296189308167,
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-0.02... |
10,003,859 | The role placed by glucose in providing energy for acid formation was studied in isolated gastric glands from rabbit. The widely-used inhibitors of glycolysis, iodoacetic acid and iodoacetamide were found to inhibit glucose oxidation as well as the indicators of acid formation, respiration and accumulation of aminopyri... | [
0.036750052124261856,
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0.013500245288014412,
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0.01740... |
10,003,860 | The proteins of living psoriatic epidermis. | [
-0.00825926661491394,
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0.029497727751731873,
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0.04128188267350197,
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0.0245495457... |
10,003,861 | Psoriatic epidermis has a rapid rate of turnover and produces a stratum corneum with an abnormal tonofilament composition. One polypeptide chain, (Mr 70,000) is absent or greatly decreased in relative amount and two other chains, (Mr 63,000 and 55,000), which are normally modified in the living cells, persists into the... | [
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0.05016395077109337,
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0.00442... |
10,003,862 | Photoaffinity labelling of the serotonin carrier protein in platelets and brain synaptosomes. | [
-0.007440043147653341,
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0.06050395220518112,
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0.05021466314792633,
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0.063313... |
10,003,863 | Azidoimipramine, a photoaffinity labelling reagent for the serotonin transport protein, was synthesized. This reagent, upon irradiation, binds covalently to brain synaptosomes preparation and to gel-filtered platelets. Two-dimensional SDS-polyacrylamide gel electrophoresis-isoelectric focusing and tritium fluorography ... | [
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0.142303615... |
10,003,864 | Structural organization of the carbohydrate moiety of human transcortin as determined by methylation analysis of the whole glycoprotein. | [
-0.038423825055360794,
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10,003,865 | Methylation analysis of human transcortin showed that this glycoprotein contains N-glycosidically linked oligosaccharide chains of N-acetyllactosamine type, most of the chains being biantennary and others tri- and/or tetra-antennary. The carbohydrate chains of transcortin are also heterogeneous with respect to the cont... | [
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0.032663993537425995,
0.04807310178875923,
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10,003,866 | De novo purine synthesis in skeletal muscle. | [
-0.04799480363726616,
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0.047223206609487534,
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-0... |
10,003,867 | Myoblast and primary muscle cultures from rat were found to contain the complete pathway of de novo purine nucleotide synthesis. Quantitative assessment of the pathway in skeletal muscle in mice in vivo, revealed a more intensive purine production in muscle than in liver. Skeletal muscle is thus a major site of de novo... | [
-0.05192836374044418,
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0.021733049303293228,
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... |
10,003,868 | Extracts of bone contain a potent regulator of bone formation. | [
-0.059615638107061386,
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0.06500954926013947,
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0.02402367815375328,
-0.0... |
10,003,869 | We prepared aqueous extracts of whole femorae and tibiae of embryonic chicks. An amount of extract containing 25 microgram of protein resulted in a 500% increase in DNA synthesis in calvarial cell culture, and significant effects were detected with 5 microgram (55%). The time course for stimulation of DNA synthesis sho... | [
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10,003,870 | Protein degradation in rat liver. Evidence for populations of protein degradation rates in cellular organelles. | [
0.05835673585534096,
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0.004324296955019236,
0.06405507028102875,
0.033357102423906326,
-0.011961368843913078,
-0.03265887871384621,
0.0703156590461731,
-0.025937359780073166,
0.0433... |
10,003,871 | Protein degradation in liver subcellular and submitochondrial fractions from adult rats has been measured by a double isotope technique. Protein subunits have been resolved by two-dimensional polyacrylamide gel electrophoresis. No consistent relationship between subunit size or isoelectric point and degradation rate ha... | [
0.06659573316574097,
-0.048013851046562195,
0.05828355625271797,
0.014175795018672943,
0.038310885429382324,
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0.024409478530287743,
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-0.029414059594273567,
0.029903197661042213,
-0.00008729277760721743,
-0.007797079626470804,
... |
10,003,872 | Protein degradation in mammary gland explants. Evidence for limited heterogeneity of protein degradation rates. | [
0.04097648337483406,
-0.06703977286815643,
0.013596989214420319,
0.009213212877511978,
0.11049957573413849,
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0.022115983068943024,
0.022760527208447456,
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0.0316988043487072,
-0.07684057950973511,
0.0788... |
10,003,873 | Mammary gland explants in organ culture were subjected to hormonal manipulation, and rates of protein degradation during 1 and 2 day periods were measured by a double-isotope method. Isotope ratios for protein subunits in subcellular fractions were measured after resolution by two-dimensional polyacrylamide gel electro... | [
0.061229266226291656,
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0.025270523503422737,
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0.07180911302566528,
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0.021180322393774986,
0.031757112592458725,
0.05504058673977852,
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0.019765252247452736,
-0.03829212486743927,
-0.05722159519791603,
0.097... |
10,003,874 | Enzyme and protein turnover in adipose tissue in pregnancy and lactation. | [
0.01176918763667345,
-0.08395078033208847,
-0.009884819388389587,
0.08003800362348557,
0.11210937798023224,
0.010586805641651154,
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0.038630999624729156,
0.015306351706385612,
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0.012241258285939693,
-0.11298910528421402,
0.004... |
10,003,875 | 1. The relative rates of synthesis of fatty acid synthetase and the pyruvate dehydrogenase complex were measured in adipose tissue in virgin, late pregnant and early lactating rats after injection of L-[2,3-3H]alanine. The relative rate of synthesis of fatty acid synthetase decreased approximately 4-fold between 2 days... | [
0.0035405270755290985,
-0.040520407259464264,
-0.07394666224718094,
0.030432671308517456,
0.06773841381072998,
0.011630923487246037,
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0.04426915571093559,
0.03291646018624306,
0.026682594791054726,
-0.02266477793455124,
-0.011360627599060535,
-0.05477997660636902,
-0.0... |
10,003,876 | Dowex-1-induced reactions of reduced nicotinamide adenine dinucleotide (NADH). | [
-0.012077649123966694,
-0.03762095421552658,
0.01507575623691082,
-0.013476801104843616,
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0.011731632985174656,
0.020022014155983925,
0.0027535618282854557,
0.06783703714609146,
0.07870817929506302,
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0.06688524037599564,
-0.07137896865606308,
-0.... |
10,003,877 | Dowex 1-formate has been found to cause both anomerization and oxidation of NADH, and when NADH is chromatographed on a column of this resin, the major products observed are NAD+ and alpha-NAD+. Competing with the oxidation reaction is the conversion of NADH and alpha-NADH to unstable acid-modification products that su... | [
-0.0014773564180359244,
-0.04706406965851784,
-0.0107985008507967,
0.01738709956407547,
0.03957875445485115,
0.07145404070615768,
0.003843058133497834,
0.04814279451966286,
0.03983553871512413,
0.025824205949902534,
-0.10339664667844772,
0.11907128989696503,
-0.07115444540977478,
0.0113101... |
10,003,878 | Regulation of putrescine metabolism in Ehrlich ascites carcinoma cells exposed to hypotonic medium. | [
-0.01580987125635147,
-0.04828924313187599,
-0.04936734214425087,
-0.036207858473062515,
-0.05494905263185501,
0.07420206815004349,
0.021165022626519203,
0.06813168525695801,
0.022692322731018066,
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0.03969467803835869,
-0.024643540382385254,
0.027285926043987274,
-0.0... |
10,003,879 | When exposed to hypotonic growth medium, Ehrlich ascites carcinoma cells showed a rapid stimulation of ornithine decarboxylase (EC 4.1.1.17) activity in 4 h, followed by a rise in their putrescine content. This effect was totally abolished by addition of a slightly hypertonic concentration of sodium chloride or sucrose... | [
-0.006300902925431728,
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0.038679301738739014,
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0.06659609079360962,
0.0678263008594513,
0.031129853799939156,
0.06150376796722412,
0.0579... |
10,003,880 | The steroid ligands of estrogen binding proteins in Xenopus laevis liver cytosol are primarily metabolites 17beta-estradiol. | [
-0.009637153707444668,
-0.031962525099515915,
-0.043310608714818954,
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0.03053266741335392,
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0.029489770531654358,
0.020525427535176277,
0.011095840483903885,
0.04048878699541092,
0.0356462262570858,
-0.006887005176395178,
-0.09318132698535919,
-0.0... |
10,003,881 | The interactions in vitro between [3H]estradiol and liver proteins from Xenopus laevis have been examined to determine if the binding reaction meets criteria of steroid-receptors which may function in the induction of vitellogenesis. Estrogenic hormones associated with proteins is serum and liver cytosol from Xenopus l... | [
0.007617816794663668,
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0.0528562106192112,
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0.01293489895761013,
0.09635457396507263,
0.00429132767021656,
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0.043340906500816345,
-0.02837160974740982,
-0.03956393152475357,
0.0058681... |
10,003,882 | Synthesis of sialoglycoconjugates during dimethylsulfoxide-induced erythrodifferentiation of friend leukemia cells. | [
-0.019739532843232155,
-0.030103908851742744,
-0.1361931413412094,
0.021549178287386894,
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0.03101576864719391,
0.007566867396235466,
0.06074118614196777,
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0.05999484285712242,
-0.016497936099767685,
-0.068... |
10,003,883 | We have previously shown that erythroid differentiation of Friend murine leukemia cells by dimethylsulfoxide results in a decrease in sialic acid content and net negative surface charge. The mechanism responsible for the decrease in sialic acid content was examined by measuring the synthesis of sialic acid from N-acety... | [
0.029628608375787735,
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0.07782800495624542,
0.03255220875144005,
0.0113... |
10,003,884 | Calmodulin and acidic compounds alter basic protein phosphorylation by the protein kinase from human platelets. | [
-0.0468796007335186,
-0.05662161111831665,
-0.08248689770698547,
0.05637899786233902,
0.01615130715072155,
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0.01042945310473442,
0.07951559126377106,
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0.018126344308257103,
0.016374610364437103,
-0.025333257392048836,
0.02326... |
10,003,885 | A cyclic nucleotide-independent protein kinase of human platelets, which phosphorylated histones, myelin basic protein and protamine and did not catalyze the phosphorylation of acidic proteins such as casein, phosvitin and myosin light chain, has been purified approx. 1,500-fold from the crude extract by steps of DEAE-... | [
-0.0702461451292038,
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0.046464819461107254,
0.0195483285933733,
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0.03935449570417404,
0.09748635441064835,
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0.005250608082860708,
0.045741159468889236,
0.021163733676075935,
-0.04676654189825058,
0.01588... |
10,003,886 | Selective appearance of heparin in mammalian tissues during development. | [
-0.010981258004903793,
-0.024851178750395775,
-0.048616472631692886,
-0.022451145574450493,
0.0373961478471756,
0.027030007913708687,
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0.05016146972775459,
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0.044493354856967926,
-0.028184736147522926,
-0.0321805365383625,
-0.04930054768919945,
0... |
10,003,887 | The distribution of heparin in tissues of bovine and porcine fetuses of different ages as well as in the adult animals is reported. Heparin is present almost exclusively in the hematopoietic and lymphoid tissues of fetuses (spleen, liver, thymus and lymph nodes), whereas ileum, skin and lung besides lymph nodes and bov... | [
0.058061614632606506,
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0.07359771430492401,
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0.0824599340558052,
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0.08553633838891983,
-0.019499842077493668,
0.008836304768919945,
0.0028348960913717747,
0... |
10,003,888 | Plasma membrane-associated component(s) that confer(s) cholera toxin sensitivity to adenylate cyclase. | [
-0.0057850065641105175,
-0.09375286102294922,
0.016217444092035294,
-0.010512636043131351,
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0.023537475615739822,
0.02937302365899086,
0.037376489490270615,
0.08567353338003159,
-0.016179166734218597,
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-0.035030562430620193,
0.08565954864025116,
0... |
10,003,889 | Incubation of crude normal rat kidney membranes with activated cholera toxin in the presence of DTP, ATP and NAD results in a 10--20 fold stimulation of adenylate cyclase activity. Optimal choleragen activation f the cyclase is shown to be dependent upon the presence of a plasma membrane-associated reconstituting activ... | [
-0.05610364302992821,
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0.05082042142748833,
-0.04536783695220947,
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0.02265898510813713,
0.04480159655213356,
0.038172826170921326,
0.0521836094558239,
-0.001960529712960124,
-0.026645096018910408,
0.02579234540462494,
0.012227753177285194,
0.146801... |
10,003,890 | Ornithine oxoacid aminotransferase found in AH 130 ascites hepatoma cells. | [
-0.05919736623764038,
0.039531245827674866,
-0.08126477897167206,
-0.05564473196864128,
-0.035619162023067474,
0.011896020732820034,
-0.05253572762012482,
0.05524500831961632,
0.03497892990708351,
0.01751052401959896,
0.0198375191539526,
-0.055565133690834045,
0.01433897390961647,
0.025726... |
10,003,891 | We found heterogenous ornithine oxoacid aminotransferase (L-ornithine: 2-oxo-acid aminotransferase, EC 2.6.1.1.3) in rat ascites hepatoma AH 130 cells. Compared with enzymes from normal rat tissues, this heterogenous enzyme showed larger Km values for 2-oxoglutarate, a different elution-profile upon affinity chromatogr... | [
-0.007570906076580286,
0.013062982819974422,
-0.03803371638059616,
-0.05588145554065704,
0.014947226271033287,
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0.0009205807582475245,
0.035554658621549606,
0.06862616539001465,
0.011041575111448765,
0.015571799129247665,
0.01483752392232418,
0.019479388371109962,
0.0... |
10,003,892 | High intralysosomal levels of lipoprotein cholesterol influence the endocytic activity and acid hydrolase content of CH-23 fibroblasts. | [
0.007299435790628195,
-0.11266317218542099,
-0.06461470574140549,
0.017884213477373123,
-0.005416343454271555,
0.0346943736076355,
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0.04199773818254471,
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-0.02207723632454872,
-0.021978741511702538,
-0.09282858669757843,
-0.0... |
10,003,893 | Lipoprotein extracts isolated from hyperlipemic rabbit serum were used to study the effects of abnormal lipid levels on the functions of the lysosomal system in Chinese hamster CH-23 fibroblasts. The ability of cells enriched with lipid to endocystose [3H]inulin was largely unimpaired and utilising density gradient fra... | [
0.005864027887582779,
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-0.07806867361068726,
0.02316085621714592,
0.04185234010219574,
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0.00006047870556358248,
0.0021760931704193354,
0.036285825073719025,
-0.017243215814232826,
0... |
10,003,894 | The interactions of tropolone with magnesium ions and tubulin. | [
-0.01744924858212471,
-0.08478626608848572,
0.0008710688562132418,
-0.03211735561490059,
-0.0409584641456604,
0.008323519490659237,
0.098432257771492,
0.06976855546236038,
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0.004511238541454077,
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0.03171975165605545,
0.07667389512062073,
-0.015935... |
10,003,895 | Tropolone, a single analog of colchicine, interacts with Mg2 with the formation of a 1 : 1 complex and an apparent equilibrium binding constant Kb of 1.4 x 10(4) M(-1) in neutral aqueous solution at 25 degrees C. The tropolone-Mg2 complex, but not tropolone, is fluorescent. Since tubulin binds Mg2 (Frigon, R.P. and Tim... | [
-0.039510373026132584,
-0.1376461684703827,
0.005547138396650553,
-0.050021059811115265,
-0.011356640607118607,
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0.05754918232560158,
0.10046921670436859,
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0.017642581835389137,
-0.02537163347005844,
0.0624992772936821,
0.09017648547887802,
-0.007... |
10,003,896 | 19F nuclear magnetic resonance studies of the coat protein of bacteriophage M13 in synthetic phospholipid vesicles and deoxycholate micelles. | [
-0.08059769868850708,
-0.10852134972810745,
-0.037767790257930756,
-0.06292293965816498,
-0.0014602121664211154,
0.03810584545135498,
-0.0006964677013456821,
0.020708167925477028,
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-0.021333040669560432,
0.007188007701188326,
0.010512663051486015,
0.014836934395134449,
... |
10,003,897 | The nonlytic, filamentous coliphage M13 offers an excellent model system for the study of membrane-protein interactions. We prepare derivatives of the protein containing fluorine-labeled amino acids and use 19F nuclear magnetic resonance (NMR) to study the protein in both deoxycholate micelles and phospholipid vesicles... | [
0.008859565481543541,
-0.1859392672777176,
-0.04133319854736328,
-0.06398706138134003,
0.01217573881149292,
0.004789786878973246,
0.0036235095467418432,
0.07741057872772217,
0.014783235266804695,
-0.03141562640666962,
0.02987860143184662,
-0.007572443690150976,
-0.02880154550075531,
0.1631... |
10,003,898 | Bilayer acyl chain dynamics and lipid-protein interaction: the effect of the M13 bacteriophage coat protein on the decay of the fluorescence anisotropy of parinaric acid. | [
-0.07680764049291611,
-0.17547985911369324,
0.0034952771384269,
-0.05074832960963249,
-0.02923397347331047,
0.04229984059929848,
-0.03501193970441818,
0.052382949739694595,
0.012595036067068577,
-0.017866723239421844,
0.07188908755779266,
-0.012230969965457916,
-0.04140544682741165,
0.0528... |
10,003,899 | Nanosecond fluorescence polarization anisotropy decay is used to determine the effect of the bacteriophage M13 coat protein on lipid bilayer acyl chain dynamics and order. The fluorescent acyl chain analogues cis- and trans-parinaric acid were used to determine the rate and extent of the angular motion of acyl chains i... | [
-0.029627658426761627,
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0.0061213369481265545,
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0.0026887848507612944,
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0.007729050703346729,
0.061271462589502335,
0.05780477449297905,
0.014026676304638386,
0.07368279993534088,
-0.025642022490501404,
-0.036334484815597534,
0.... |
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