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From light bulbs to CT scanners, group purchasing is filling the bill at a lower price.
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Survey points to need for more efficient inventory management.
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] |
10,000,402
|
Administrators must understand and support the purchasing function.
|
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] |
10,000,403
|
Hospitals must conduct ongoing review of their policies on "disposables versus reusables'.
|
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] |
10,000,404
|
What to buy and how to get it: the cash flow factor.
|
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] |
10,000,405
|
Nonenzymatic galactosylation of human serum albumin. In vitro preparation.
|
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] |
10,000,406
|
Incubation of purified human serum albumin with D-[1-14C]galactose (5 mM) or D-[1-14C]glucose (5 mM) in vitro for 7 days under physiological conditions resulted in the time-dependent accumulation of radioactivity into trichloroacetic acid-precipitable material. Comparative studies indicated that the rate of sugar incorporation into albumin increased with increasing pH and temperature of incubation and followed a first order dependence with regard to monosaccharide and albumin concentrations. The extent of nonenzymatic galactosylation of human albumin was approximately 300% greater than the extent of nonenzymatic glucosylation under equivalent experimental conditions. Prolonged dialysis of the modified albumins against a large excess of the unlabeled monosaccharides failed to alter the amount of protein-bound radiolabeled carbohydrate, suggesting that the linkage between sugar and albumin is covalent in nature. The post-translational modification of proteins by nonenzymatic galactosylation may be of physiological significance in individuals with reduced galactokinase or galactose-1-phosphate uridyl transferase activities.
|
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] |
10,000,407
|
Heterogeneous metabolism and subcellular localization of a potentially leukemogenic membrane glycoprotein encoded by Friend erythroleukemia virus. Isolation of viral and cellular processing mutants.
|
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] |
10,000,408
|
Purification and characterization of chicken liver T-protein, a component of the glycine cleavage system.
|
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] |
10,000,409
|
T-protein, a component of the glycine cleavage system, has been purified to apparent homogeneity from chicken liver mitochondria. The molecular weight was 37,000 by sedimentation equilibrium centrifugation and 38,000 by gel filtration. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis gave a molecular weight of 41,000, indicating that the protein is composed of a single polypeptide. A partial specific volume of 0.73 ml/g was obtained from the amino acid composition. The absorbance coefficient, A1%280nm, is 6.63 in 50 mM potassium phosphate buffer, pH 7.0. T-protein is a basic protein having a pI value of 9.8 and relatively rich in arginine rather than lysine. The protein catalyzed the degradation of the protein-bound intermediate (-CH2NH2 moiety of glycine) to a 1-carbon unit and NH3. The reaction is dependent on tetrahydrofolate (H4-folate). Apparent Km values for the intermediate and H4-folate were 3.7 microM and 0.17 mM, respectively. T-protein associated with H-protein forming a complex which was composed of one molecule each of T-protein and H-protein. Formation of the complex was not affected by the modification of the cysteinyl residues on H-protein with N-ethylmaleimide.
|
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] |
10,000,410
|
The structure of partially oxygenated hemoglobin. A highly reactive intermediate toward a sulfhydryl titrant.
|
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] |
10,000,411
|
It is known that Cys beta 93 in hemoglobin A reacts with sulfhydryl reagents more rapidly in the oxy than in the deoxy form. In this study, the reaction of the residues toward 4,4'-dithiodipyridine was measured at various degrees of saturation with O2. Analysis of initial rates of the reaction revealed that an intermediate, which reacts even more rapidly than the oxy form, occurs in the course of O2 binding to hemoglobin A, especially at higher degrees of saturation. Its occurrence was independent of the overall O2 affinity of hemoglobin. Time courses of the reaction were measured at pH 8.0, where the change in O2 saturation of hemoglobin by the 4,4'-dithiodipyridine reaction is negligible, and they were analyzed by the curve-fitting procedure. It was found that the rapidly reacting species appears in parallel with the Adair intermediate carrying three O2 molecules, and their close relationship was suggested. Furthermore, the analysis of the time course indicated the existence of another molecular species with an intermediate reactivity between those of oxy and deoxy forms. It was concluded that the ligand-linked structural changes in hemoglobin take place through several steps.
|
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] |
10,000,412
|
2-Thioflavins as active site probes of flavoproteins.
|
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] |
10,000,413
|
A non-calcitonin secretory peptide derived from preprocalcitonin.
|
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] |
10,000,414
|
Asymmetric metabolism of phosphatidylethanolamine in the human red cell membrane.
|
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] |
10,000,415
|
The incorporation of labeled fatty acids into phosphatidylethanolamine (PE) on the two sides of the human red cell membrane was studied by use of the vectorial probe trinitrobenzene sulfonate (TNBS). A small population of PE molecules on the outer surface of the membrane has a 4-fold higher turnover rate than the remaining PE molecules. This effect is greatest with palmitic acid, less with linoleic and linolenic acids, and not seen with stearic acid. By use of the hydrophobic penetrating probe fluorodinitrobenzene (FDNB), we find a second larger population of PE and phosphatidylserine (PS) molecules which reacts with FDNB and has a higher specific activity than the PE and PS molecules which do not react. With human polymorphonuclear cells, the labeled PE molecules inside the cell have a higher specific activity than the PE molecules located on the outer cell surface. These results suggest that there are heterogeneous populations of PE and PS on both halves of the red cell membrane which show different metabolic turnover rates of their fatty acids.
|
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] |
10,000,416
|
In vitro biosynthesis of the tetrasialoganglioside GQ1b.
|
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10,000,417
|
A sialyltransferase activity which catalyzes the synthesis of the tetrasialoganglioside GQ1b (N-acetylneuraminyl-N-acetylneuraminylgalactosyl-N-acetylgalactosaminyl [N-acetylneuraminyl-N-acetylneuraminyl]-galactosylglucosylceramide) from added trisialoganglioside GT1b (N-=acetylneuraminylgalactosyl-N-acetylgalactosaminyl [N-acetylneuraminyl-N-acetylneuraminyl]galactosylglucosylceramide) and CMP-N-acetyl[4-14C]neuraminic acid has been demonstrated using a membrane fraction of embryonic chick brain. Optimum enzymatic activity was obtained using the detergent Triton CF-54 at a pH of 6.6. Enzyme activity appeared unaffected by Ca2+, Mg2+, Mn2+, EDTA, or histone. A slight elevation in activity was seen in the presence of Hg2+. When the disialoganglioside GD1b (galactosyl-N-acetylgalactosaminyl [N-acetylneuraminyl-N-acetylneuraminyl]galactosylglucosylceramide) was used as the glycolipid substrate, approximately 15% of the radioactive label was found in GQ1b. When this GQ1b was subjected to a periodate oxidation-borohydride reduction, the distribution of radioactive label was consistent with GQ1b being the major tetrasialoganglioside product and that its synthesis could proceed via the sequence GD1b-GT1b-GQ1b.
|
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10,000,418
|
Effect of p-nitrophenyl-beta-D-xyloside on proteoglycan and glycosaminoglycan biosynthesis in rat serosal mast cell cultures.
|
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] |
10,000,419
|
Rat serosal mast cells cultured in the presence of heat-inactivated fetal calf serum incorporated (35S) sulfate into heparin proteoglycan of approximately Mr = 750,000 after a 3-h pulse and a 2-h chase. beta-D-Xyloside (0.1 mM) treatments of cultures of rat mast cells resulted in an insignificant increase in total (35S) sulfate incorporation and the appearance of free glycosaminoglycans without a change in proteoglycan size. At higher beta-D-xyloside concentrations, total (35S)sulfate incorporation was inhibited and an increase in the relative glycosaminoglycan content was observed concomitant with a reduction in proteoglycan amount and size. As assessed by susceptibility to digestion by chondroitinase ABC, hydrolysis by nitrous acid, [3H]hexosamine content, and electrophoretic mobility, only heparin chains were polymerized onto the proteoglycan core in all cultures. In contrast, individual glycosaminoglycans which appeared only after beta-D-xyloside treatment were predominantly chondroitin sulfate rather than heparin, indicating that the beta-D-xyloside acceptor supported polymerization of chondroitin sulfate but not of heparin glycosaminoglycan. Thus, the peptide core is an important determinant for the synthesis of heparin glycosaminoglycan by rat peritoneal mast cells.
|
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] |
10,000,420
|
The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin.
|
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] |
10,000,421
|
pH gradient-dependent phosphate transport catalyzed by the purified mitochondrial phosphate transport protein.
|
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] |
10,000,422
|
The mitochondrial phosphate transport protein (Wohlrab, H. (1980) J. Biol. Chem. 255, 8170-8173), which co-purifies with the adenine nucleotide translocase, has been isolated with a modified procedure resulting in an increased yield and in a preparation that is stable to storage in liquid nitrogen. The phosphate transport protein was incorporated into liposomes (phosphatidylethanolamine/phosphatidylcholine/phosphatidic acid, 2.75:1:1), and phosphate/phosphate exchange rates were determined. With pHe (extraliposomal) = pHi (intraliposomal) = 7.2, we found a Km of 2.5 mM independent of [(Pi)i] and a Vmax of 12 mumol/min . mg of protein. Parallel phosphate transport experiments were carried out with liposomes containing phosphate transport protein isolated from mitochondria inhibited by N-ethylmaleimide. Phosphate transported unidirectionally [pHe = pHi = 6.8; = 1.0 mM, (Pi)i = 0 mM] reaches a maximum at 30 s and is 0.13 and 0.05 mumol/mg for active and inhibited protein, respectively. At pHe = 6.8 and pHi = 8.0, the respective amounts are 0.45 and 0.05. At pHe = 8.0, the uptake becomes the same with active and inhibited protein (pHi = 6.8, 0.15 and 0.14; pHi = 8.0, 0.25 and 0.20). At all the above pH values, about the same uptake is observed with liposomes prepared without protein as those prepared with inhibited protein. The initial rate of protein catalyzed unidirectional flux [(Pi)e = 1.0 mM, pHe = 6.8; (Pi)i = 0 mM, pHi = 8.0) is 2 mumol/min . mg of protein or 8 mumol/min . mg of phosphate transport protein estimated without the adenine nucleotide translocase.
|
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] |
10,000,423
|
Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting.
|
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] |
10,000,424
|
Rabbit Fab' antibody fragments were covalently couple to preformed large unilamellar vesicles using a new sulfhydryl-reactive phospholipid derivative N-[4-(p-maleimidophenyl)butyryl]phosphatidylethanolamine (MPB-PE). A highly efficient reaction between the sulfhydryl group on each Fab' fragment and the maleimide moiety of MPB-PE molecules incorporated at a low concentration in vesicle bilayers led to the formation of a highly stable Fab'-vesicle linkage. Coupling ratios in excess of 250 micrograms of Fab'/mumol of vesicle phospholipid were reproduciably obtained without vesicle aggregation. Bound Fab' fragments did not elute from vesicles in serum or in the presence of reducing agents (dithiothreitol or mercaptoethanol). Vesicles bearing Fab' fragments raised against specific human erythrocyte surface determinants bound selectively to human erythrocytes under physiological conditions (isotonic medium containing 50% human serum, pH 7.4) with minimal leakage of vesicle contents. Advantages of the present coupling method are discussed in relationship to our effects to optimize the properties of liposomes as a carrier system.
|
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] |
10,000,425
|
Reduced sulfhydryl groups are required for activation of uterine progesterone receptor. Possible involvement of an inhibitor of activation.
|
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10,000,426
|
The dependence of uterine progesterone receptor activation on sulfhydryl groups was studied using binding to DNA-cellulose as a measure of activated receptor. Dithiothreitol, thioglycerol, or other sulfhydryl reducing reagents stimulated receptor activation 2- to 3-fold. This effect was produced under mild conditions, i.e. after a 22-h incubation at 0-3 degrees C with 50 mM dithiothreitol. Other characteristics of the sulfhydryl-dependent stimulation of receptor activation, such as pH-dependence and sensitivity to the sulfhydryl blocking agent iodoacetamide, suggest that the sulfhydryl groups essential for receptor activation are different from those involved in steroid binding. Progesterone receptor activation by sulfhydryl reduction was a reversible process, dependent on addition or removal (by dialysis) of the reducing agent. Optimal receptor activation (up to 75% of total receptor) occurred when cytosol was diluted with buffer in the presence of dithiothreitol, suggesting that dissociation of either a receptor subunit or an inhibitory factor present in cytosol may also be involved in the activation process. This putative inhibitor appears to have a Mr greater than or equal to 30,000 since it is not removed from cytosol by dialysis or gel filtration. These results emphasize the importance of sulfhydryl groups or a disulfide bridge, perhaps associated with the DNA-binding domain of the receptor, in a key regulatory step in the mechanism of steroid hormone action: activation and subsequent binding of the steroid-receptor complex to DNA or chromatin.
|
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] |
10,000,427
|
Incorporation of defined cholesteryl esters into lipoproteins using cholesteryl ester-rich microemulsions.
|
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10,000,428
|
Cholesteryl ester transfer to low density lipoproteins (LDL) was achieved either by incubation of a cholesteryl ester-rich lipid microemulsion with whole plasma or by incubation of the cholesteryl ester-rich microemulsion with lipoprotein-free plasma and LDL. Sequential ultracentrifugal isolation gave LDL that contained between 5 and 37% of the cholesteryl ester derived from the artificial cholesteryl ester donor. The labeling was essentially complete within 2 h of incubation. Resonance energy transfer of LDL, labeled with fluorescent cholesteryl esters and with the surface probe 5-(N-hexadecanoylamino) fluorescein, indicated that the added cholesteryl ester was located in the inner core of the lipoprotein. In addition, biological screening of the labeled LDL in cultured cells in vitro and in the rat in vivo showed that this labeling procedure had no detectable deleterious effect on LDL. This method of labeling lipoproteins allows a rapid and specific introduction of cholesteryl esters into lipoproteins.
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] |
10,000,429
|
Incomplete correspondence between repressive and substrate action by amino acids on transport systems A and N in monolayered rat hepatocytes.
|
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] |
10,000,430
|
Stimulation of System N transport of glutamine by amino acid starvation of the rat hepatocyte can be repressed by one of its substrates, histidine, but not by two others, glutamine or asparagine. Furthermore, 2-(methylamino)isobutyric acid is also repressive, although it is not perceptibly a substrate or inhibitor of that system. The repression of System A by glutamine proves in contrast not to be dissociated from transport: relatively slow System A uptake of glutamine has now been shown in this cell. System A transport of glutamine is conspicuous in the hepatoma cell HTC and is increased after amino acid starvation of both hepatocytes and the hepatoma cells. Differential repression of the systems could be shown, although lowering the pH prevented the derepression of one system as much as the other on amino acid starvation.
|
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] |
10,000,431
|
Characteristics of an endogenous glucocorticoid receptor stabilizing factor.
|
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] |
10,000,432
|
Interaction of cytochalasin B with actin filaments nucleated or fragmented by villin.
|
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] |
10,000,433
|
Villin, a 95,000-dalton protein, is a major component of microvillus cores isolated from intestinal brush borders. In this study, we compared the Ca2+-dependent action of this protein on actin filaments with that of cytochalasin B, a fungal metabolite that binds to the "barbed" end of actin filaments and nuclei. We found that substoichiometric levels of villin inhibit actin filament elongation and self-association in a cytochalasin-like manner. In addition, the protein releases membrane-bound F-actin in the absence of high shear force, probably by severing the filaments. The filament fragments formed in the presence of villin, as well as a nucleating complex consisting of villin and actin, bind stoichiometric amounts of [3H]cytochalasin B with high affinity. The results of this study indicate that both villin and cytochalasin B bind to the same end of actin filaments, yet differ in their binding sites.
|
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] |
10,000,434
|
Heparin with two binding sites for antithrombin or platelet factor 4.
|
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] |
10,000,435
|
A new, highly discriminating affinity chromatographic technique has been developed which employs antithrombin and concanavalin A-Sepharose to fractionate heparin species of all molecular sizes. This methodology is able to subdivide the active mucopolysaccharide pools of molecular weight 6,000 to 8,000 (LMW) or 18,000 to 22,000 (HMW) into various species with descending affinities for antithrombin as well as decreasing anticoagulant potencies. The upper 10% of these two pools, either LMW or HMW highly active heparin, appears to be relatively homogeneous with respect to interactions with antithrombin and possessed anticoagulant potencies of 350 units/mg and 731 units/mg, respectively. The HMW highly active heparin has been examined by analytic ultracentrifugation. It exhibited a charge-connected weight-average molecular weight of 22,000 +/- 2,000 with minimal size heterogeneity. The stoichiometries of interaction of antithrombin and platelet factor 4 with HMW highly active heparin as determined by fluorescence spectroscopy indicated that 2 molecules of either protein are able to bind to 1 molecule of the mucopolysaccharide. These studies also reveal that the binding of antithrombin to HMW highly active heparin is characterized by KDISSHAT = 5.0 X 10(-8) M and KDISSHAT2 = 1.0 x 10(-7) M, respectively. The avidity of platelet factor 4 for HMW highly active heparin could not be quantitated but appears to be at least 10 to 100 times greater than that of antithrombin for mucopolysaccharide.
|
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10,000,436
|
Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues.
|
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] |
10,000,437
|
In rat livers and hepatomas, carbamoyl phosphate synthetase (glutamine-hydrolyzing) (EC 6.3.5.5) (synthetase II), the rate-limiting enzyme of de novo pyrimidine nucleotide biosynthesis, was separated from carbamoyl phosphate synthetase (ammonia) (EC 6.3.4.16) (synthetase I) ammonium sulfate and hydroxylapatite fractionations and gel filtration on Sephadex G-25. Both liver and hepatoma 3924A synthetase II activities were subject to feedback inhibition by UTP and to stimulation by 5-phosphoribosyl 1-pyrophosphate. UTP (0.5 mM) enhanced the apparent Km for MgATP from 2.3 to 7.6 mM, whereas 0.1 mM 5-phosphoribosyl 1-pyrophosphate reduced it to 0.5 mM. At 2 mM MgATP, 3 or 7 microM 5-phosphoribosyl 1-pyrophosphate yielded half-maximal activation (Ka) in the absence or presence of 0.5 mM UTP; UTP altered the stimulation kinetics from hyperbolic to sigmoidal. In the rat, synthetase II activities were highest in thymus, testis and spleen. In differentiating and regenerating rat livers, activities were 2.2- and 1.5-fold higher than in adult livers. In 17 hepatomas of different growth rates, synthetase II activity increased 1.3- to 9.5-fold over liver values; the rise correlated positively with tumor growth rates. Synthetase II activities also increased in a kidney tumor (5.0-fold) and in a sarcoma (18.1-fold) in the rat and in a human colon tumor (3.3-fold).
|
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] |
10,000,438
|
Structures of branched blood group A-active glycosphingolipids in human erythrocytes and polymorphism of A- and H-glycolipids in A1 and A2 subgroups.
|
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] |
10,000,439
|
The structures of two branched variants of blood group A-active glycolipid, Ac and Ad (Hakomori, S., Stellner, K., and Watanabe, K. (1972) Biochem. Biophys. Res. Commun. 49, 1061-1068), isolated from human type A-erythrocytes, were elucidated. The intact glycolipids and fragments produced by treatment with endo-beta-galactosidase from Escherichia freundii (Fukuda, M. N., and Matsumura, G. (1976) J. Biol. Chem. 251, 6218-6225) were analyzed by methylation. In addition, a specific limited enzyme digestion of Ad-glycolipid was made by incorporating the glycolipid into liposomes before endo-beta-galactosidase digestion. The method preferentially hydrolyzed one of the side chains carrying an A-determinant leaving a core which was recovered from the liposomes. The Ac- and Ad- glycolipids have two branched carbohydrate chains with 12 and 14 sugar residues, respectively, and both have two A-determinants as shown below. (formula see text). The structures of A- and H-active variants isolated from subgroups A1 and A2 have been compared. The results indicate that A variants from A1 or A2 erythrocytes have identical structures, and that H-variants isolated from A2 erythrocytes are identical to those isolated from O erythrocytes. Thus, there is no qualitative structural difference in A-active glycolipids between A1 and A2 erythrocytes.
|
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] |
10,000,440
|
Solubilization of nuclear structures by the polyanion heparin.
|
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] |
10,000,441
|
Rat liver nuclei were treated with different concentrations of the polyanion heparin, at low ionic strength and in the absence of divalent cations. Heparin at the optimal concentration (Heparin:DNA greater than or equal to 1) completely solubilized the intranuclear structures, allowing the preparation of pure nuclear membranes. The majority of the nuclear proteins, including all of H1 and 70% of the core histone oligomers, were solubilized. By contrast, suboptimal concentrations of heparin (heparin:DNA less than 0.3) resulted in the selective solubilization of non-histone proteins and the partial solubilization of chromatin without dissociation of histones from DNA. Among the RNA- and DNA-associated non-histone proteins revealed by the heparin fractionation procedure, some are noteworthy. A DNA-associated protein of 40,000 daltons was found to be associated with core histone oligomer. Three proteins of Mr = 62,000, 70,000, and 74,000, identical with that of the lamina proteins, were distinguished by their presence in all the fractions obtained, their predominance in the less soluble fractions, and their tight association with DNA and RNA. More than the solubilization of the histones, their extraction seems to be a prerequisite for chromatin solubilization by heparin.
|
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] |
10,000,442
|
Lipid effects on the binding properties of a reconstituted insulin receptor.
|
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] |
10,000,443
|
The turkey erythrocyte membrane insulin receptor was solubilized and reconstituted into vesicles composed of either soy or dimyristoyl phosphatidylcholine. Reconstitution with soy phosphatidylcholine provided a lipid environment containing 43% unsaturated fatty acids, as compared with 82% saturated fatty acids in the dimyristoyl phosphatidylcholine preparation. After reconstitution, both species of vesicles were isolated from a 2 to 30% continuous sucrose gradient at a density of 1.071 g/ml. Scatchard analysis of binding data obtained at 15 degrees C revealed that the reconstituted receptor had a greater affinity for [125I]iodoinsulin in the saturated lipid environment (Ke = 0.167 nM-1; K1 = 2.18 nm-1) than in the unsaturated lipid environment (Ke = 0.0162 nM-1; K1 = 0.479 nm-1). Low affinity binding also was increased in the saturated vesicles. These increases were paralleled by a reduction in the number of available insulin binding sites in the saturated lipid environment. There was no difference, however, in the relative affinity of the reconstituted receptor preparations for insulin or proinsulin. Electron microscopy and gel filtration indicated that the binding differences are not due to differences in vesicle size. They also are not due to differences in the orientation of the receptor within the lipid bilayer, for its sensitivity to trypsin digestion was similar in both types of vesicles. Solubilization studies with 1% beta-octylglucoside indicated, however, that the dimyristoyl phosphatidylcholine vesicles incorporated a slightly lesser amount of insulin receptor. Similar results were also observed at 37 degrees C. These results suggest that the membrane lipid environment, especially the degree of unsaturation of the phospholipid fatty acyl chains, can influence the binding properties of the insulin receptor.
|
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] |
10,000,444
|
Distribution and metabolism of 3H-labeled leukotriene C3 in the mouse.
|
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0.02260964922606945
] |
10,000,445
|
The distribution of [5,6,8,9,11,12-3H6]leukotriene C3 in mice was determined by whole body autoradiography of sagittal sections. Tritium was rapidly eliminated from the circulation by uptake in liver and excretion in bile as well as by renal uptake and excretion in urine. Chromatographic analyses of tritium in tissues and body fluids indicated that leukotrienes C3 and D3 constituted significant parts of the radioactivity in liver, bile, and small intestine 20 min after intravenous injection, whereas kidney contained leukotriene E3 and unidentified metabolites. Lung, pleural fluid, spleen, salivary glands, and connective tissue showed higher concentrations of tritium than blood. The radioactivity in lung consisted predominantly of leukotriene E3 with smaller amounts of leukotrienes C3 and D3.
|
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] |
10,000,446
|
Changes in tropomyosin during development of chick embryonic skeletal muscles in vivo and during differentiation of chick muscle cells in vitro.
|
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] |
10,000,447
|
We have studied the changes in tropomyosin subunits and their pattern of phosphorylation during embryonic development and also during in vitro differentiation of cultured muscle cells. We have found that in 10-day-old embryos tropomyosin consists of 75% beta subunit and 25% alpha subunit. However, only 60% of the beta subunit is phosphorylated while the alpha subunit is almost exclusively present in its phosphorylated form. During subsequent development, the amount of alpha-tropomyosin increases so that by hatching it represents 50% of the total subunits. During the same time, the amount of phosphorylated variants for both the alpha and the beta subunits decreases so that after hatching they represent less than 20% of each subunit. In cultures of differentiating myoblasts, the alpha subunit is synthesized before the beta subunit, and within each subunit, the unphosphorylated variants are the first to be synthesized. The reason for this discrepancy is not known at the present time.
|
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] |
10,000,448
|
Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small intestine.
|
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] |
10,000,449
|
The epithelial cells of rat small intestine (jejunum-ileum) were separated from their supporting stroma (residue). Total nonacid and acid glycosphingolipids were prepared from the two compartments. The acetylated nonacid glycolipids were separated into 10-12 fractions by column chromatography. These were analyzed by chromatographic methods, mass spectrometry, and proton NMR spectroscopy and compared with glycolipids isolated from whole rat small intestine. The sialic acid-containing glycosphingolipids were compared in the same way without subfractionation. At least 37 different glycosphingolipids (different carbohydrate moieties) were found, 23 in the nonepithelial residue and 17 in the epithelial cells of one rat strain. In a second rat strain, another 4 structures were detected. The glycosphingolipids of epithelial cells and nonepithelial residue were distinctly different. Glucosylceramide, lactosylceramide, and globotriaosylceramide were found in both compartments, while isoglobotriaosylceramide was restricted to the nonepithelial residue. A tetrahexosylceramide with a terminal Gal alpha 1 leads to 3 on a globotriaosylceramide core was found in both compartments as were homologues with 1 or 2 additional internal leads to 3Gal alpha 1 leads to units, but homologues with 3 or 4 additional internal Gal were only nonepithelial. Glycosphingolipids with terminal beta-GalNAc were restricted to the nonepithelial residue comprising globotetraosylceramide, isoglobotetraosylceramide, and a series of glycolipids with 5 to 9 sugars having the above-mentioned oligohexosylceramides as core structures. Fucolipids (blood group H) having 3, 5, 6, and 7 sugars and lacking amino sugars, and fucolipids with 5 and 10 sugars containing N-acetylglucosamine were restricted to the epithelial cells. Fucolipids (blood groups H and B) with 5 and 6 sugars containing N-acetylgalactosamine were restricted to the nonepithelial residue. In a 4, 6, and 12 sugars were found in the epithelial cells. N-Glycoloylneuraminosyllactosylceramide was the only ganglioside found in the epithelial cells while N-acetylneuraminosyllactosylceramide was nonepithelial together with gangliosides based on gangliotetraosylceramide and isoglobotetraosylceramide.
|
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] |
10,000,450
|
Active subunits in hybrid-modified malate dehydrogenase.
|
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] |
10,000,451
|
Inactivation of porcine heart mitochondrial malate dehydrogenase (L-malate: NAD+ oxidoreductase, EC 1.1.1.37) by selective modification of an active center histidine residue with the reagent iodoacetamide has been further investigated to examine the existence of and the enzymatic activity of a hybrid (half)-modified dimer. The loss of enzymatic activity during iodo(1-14C) acetamide modification is linear with 14C incorporation. Enzyme was modified to various extents and the reaction was quenched. Microzonal electrophoresis was performed to separate native dimeric enzyme, hybrid-modified enzyme, and doubly modified enzyme. The distribution of each species was quantitated by scanning densitometry. The distribution generated throughout the time course of inactivation indicates that both subunits are modified independently and at the same rate. It is apparent that the hybrid-modified dimer contributes one-half of the enzymatic activity of a native dimer in the standard assay. Kinetic studies were performed and the results indicate that there is no apparent change in kinetic parameters between a subunit of the native dimer and the active subunit in the hybrid-modified dimer. Dissociation and reassociation of a mixture of native enzyme and doubly-iodoacetamide-modified enzyme indicates that there is no preferential association of a modified subunit with another modified subunit, or of a native subunit with another native subunit, but rather, association is random with respect to native and iodoacetamide-modified subunits.
|
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] |
10,000,452
|
Favored sites for thyroid hormone formation on the peptide chains of human thyroglobulin.
|
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] |
10,000,453
|
Intracellular glycosylation of vitellogenin in the liver of estrogen-stimulated Xenopus laevis.
|
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] |
10,000,454
|
Pulse-chase experiments measuring the rates of incorporation of radiolabeled glucosamine and galactose into intracellular vitellogenin show that glycosylation of this multicomponent protein occurs in a Golgi-enriched fraction isolated from homogenized liver slices. No apparent role of the rough endoplasmic reticulum in this process was demonstrable. Kinetics of the intracellular translocation of glycosylated vitellogenin indicate that the galactosylated intermediate is secreted more rapidly than the glucosamine-labeled precursor. This was corroborated by measuring the rates of accumulation of various pulse-labeled forms of vitellogenin in the chase medium. In addition, a negligible amount of mannose was incorporated into intracellular or secreted vitellogenin. The antibiotic tunicamycin was shown to inhibit [3H] glucosamine incorporation into microsomal vitellogenin by 70%, without any significant effect on the synthesis of the protein backbone. In addition, nonglycosylated vitellogenin showed normal secretion kinetics. After suitable pretreatment with the antibiotic followed by a labeling period in tunicamycin-free medium, mannose was still not incorporated into vitellogenin, whereas glucosamine behaved in a typical manner. In contrast to this finding, gas-liquid chromatography of the alditol acetate derivatives of the neutral hexoses of vitellogenin showed that mannose was indeed a major component of the vitellogenin oligosaccharide side chain. These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine. With respect to the subcellular localization of glycoprotein assembly in Xenopus liver, there is a significant departure from currently accepted models of glycoprotein synthesis.
|
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] |
10,000,455
|
The epidemiology of high density lipoprotein cholesterol levels in post-menopausal women.
|
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] |
10,000,456
|
High density lipoprotein cholesterol (HDLc) appears to be the most important risk factor of heart attack where increased HDLc levels are associated with reduced heart attack risk. Little is known regarding the determinants of HDLc in older women. The current research investigated possible HDLc correlates in 75 post-menopausal women. Obesity was negatively related and was the strongest determinant. Alcohol consumption and physical activity were also highly related. Of importance was that physical activity was related but only at the highest levels (greater than or equal to 2,000 Kilo-Calories per week). The increased levels of HDLc as a function of physical activity was very interesting because the activities were of relatively low intensity suggesting that the amount of activity rather than intensity was the primary physical activity determinant of HDLc.
|
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] |
10,000,457
|
Sex differences in life satisfaction among the elderly.
|
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] |
10,000,458
|
Sex differences in life satisfaction are a recurrent research issue in the field of social gerontology. However, the evidence concerning the effect of sex on morale is still inconclusive. This may be due to (a) the neglect of other relevant variables, (b) the failure to distinguish between main effects and interaction effects, and (c) the lack of formal statistical tests in making comparisons. In this study, a causal model of life satisfaction is proposed and evaluated by using four data sets with sample sizes ranging from 961 to 3,996. The proposed structural model fitted both the male and female subsamples reasonably well. The findings were also replicated across these four data sets. No systematic sex difference was found in terms of structural parameters. This indicates that the same causal mechanism is operating among the males as well as the females.
|
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] |
10,000,459
|
Adaptation to marital separation in later and earlier life.
|
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10,000,460
|
In recent years, the divorce rate has increased markedly for people of all ages. Whereas the consequences of the divorce experience for those in young adulthood have received considerable attention, relatively little is known about their impact on older adults. This paper evaluates the psychosocial functioning of recently separated men and women (N = 310) ranging in age from 20 to the 70s. Included in the analyses were measures of morale, psychiatric symptoms, time perspective, self-reported physical health, social disruption, personal disruption, and divorce-induced upset. The older respondents exhibited more psychosocial distress than did the younger, whereas sex differences suggested that men and women have different vulnerabilities.
|
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] |
10,000,461
|
Time budgets of older people:" a window on four lifestyles.
|
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] |
10,000,462
|
The purposes of this research were first to describe how a group of urban elderly spend their days and, second, to examine the responsiveness of the behavioral day to rather marked environmental and personal differences. Detailed time budgets for one full day (including the content, duration, social and environmental context, and the amount of liking for each activity) were obtained from 535 persons, from four groups: independent community residents, public housing tenants, recipients of intensive in-home services, and an institutional waiting list group. Consistent patterns appeared across groups, particularly in the amount of time spent in the various social contexts and in most discretionary activities. However, the independent groups spent more time than the service groups away from home and in obligatory tasks such as housework, cooking, and shopping. Independent groups tended to express greater liking for many activities but not for more novel activities which the service groups liked equally as well.
|
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] |
10,000,463
|
Myocardial kinetics and organ distribution of thallium-201 in two different age groups of rats.
|
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] |
10,000,464
|
Effects of aging were investigated on kinetics and distribution of 201 thallium (201TI) in isolated myocardial tissue and other organs of rats after injection in vivo of this radionuclide. Older rats showed a trend toward lesser organ uptake, but this was statistically significant only in kidneys, fat, and fur. Experimental outflow curves for 201TI from isolated myocardial wall segments revealed a sustained higher level of 201TI in the older rats throughout the outflow. Further analysis of the washout kinetics with a three-compartment model (extracellular, intracellular, and subcellular) showed a significant reduction of extracellular compartment and increase of subcellular compartment in older rats. The extracellular to overall intracellular ratio also decreased significantly in the older rats. The changes found for 201TI in extracellular and subcellular myocardial compartments in older rats at rest are also similar to those seen in myocardium of young rats after exercise. It is concluded that, although aging has effects on distribution of 201TI in myocardium, such effects are not likely to impair the quality of myocardial scintigraphy in older patient
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] |
10,000,465
|
Age-related changes in monosynaptic reflex excitability.
|
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] |
10,000,466
|
The excitability of the H-reflex was tested in a younger group (19 to 31 years) and an older group (60 to 72 years) of subjects. The threshold for the H-reflex was higher and the reflex latency was 7 msec longer in the older group of subjects. Also, the H-reflex amplitude was significantly smaller, longer in duration and polyphasic in shape whereas the time delay between the M-response and the H-reflex (central latency) was 5 msec longer in the older group. The H-reflex recovery curves of the older subjects demonstrated a longer primary inhibition period (94 msec in older subjects, 44 msec in younger subjects) and was slower, more inhibited, and took a longer time for maximal recovery. In accordance with previous findings, these results are attributed to possible central as well as peripheral and muscle fiber defects in old subjects. Such changes must be taken into account when using H-reflex tests in the clinic.
|
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] |
10,000,467
|
Ploidy of human embryonic fibroblasts during in vitro aging.
|
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] |
10,000,468
|
The DNA content of single nuclei in confluent cultures of aging human embryonic fibroblasts, TIG-3, was measured by means of flow cytofluorometry. In the early and late stages of their in vitro lifespan, they had considerable numbers of 4C, 8C and 16C nuclei. In the other period more than 95% of their nuclei were 2C nuclei. These results were confirmed by karyotype analysis. Presumably, the polyploid cells in young cell populations are removed due to their low growth potential and those in old cell populations are accumulated as a result of cellular aging. The saturation density of TIG-3 cells increased at the beginning of their lifespan and thereafter decreased. The rise in their saturation density seems to reflect cell selection advantageous for young diploid cells.
|
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] |
10,000,469
|
Inverse correlation between species life span and specific cytochrome P-448 content of cultured fibroblasts.
|
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] |
10,000,470
|
The quantity and type of microsomal cytochrome P-450 was determined in early passage cultured fibroblasts from six mammalian species of widely differing life spans. The proportion of cytochrome P-450 and P448 varied considerably among species, with the shorter-lived species having a preponderance of cytochrome P-448. There was a good inverse correlation between potential species life span and the specific cytochrome P-448 content of cultured fibroblasts.
|
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] |
10,000,471
|
Emotionality and aging: a theoretical and empirical analysis.
|
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] |
10,000,472
|
Much has been written about mood, emotionality, and affect in humans, but rarely has this topic been addressed from an adult developmental perspective. Indeed, the major theories on the determinants of human emotions have little to say about emotionality through middle and old age. Theories and data from several disciplines including psychology, sociology, gerontology, biology, and neurophysiology are integrated to propose answers to the following questions: (a) Do the intensity and duration of emotional experiences vary with age? (b) Do the aged show less day-to-day or within-day variability in emotional states? (c) Are particular types of emotional experiences more or less frequent among the aged? (d) Are there qualitative differences in the experience of specific emotional states among the aged? (e) Do the types of events that elicit emotional experience change with age?
|
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] |
10,000,473
|
A comparison of the emitted late positive potential in older and young adults.
|
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] |
10,000,474
|
An emitted potential paradigm was used to investigate P3 scalp potentials in a group of older individuals (M = 66.8 years) and a group of younger persons (M = 22.0 years). Since no physical stimulus is necessary to elicit an emitted potential, an age comparison of P3 can be made which does not depend on normal sensory transmission channels. Both traditional and latency corrected averages to missing auditory clicks were analyzed from electrodes placed over midline frontal, central, and parietal locations. Results indicated that while the scalp distribution of emitted potentials was similar for both age groups, amplitudes at Pz and Cz were significantly smaller in the older group. Latency corrected potentials indicated similar trends but did not reach significant levels. No group differences were seen for N2 or P3 latencies for either traditional or corrected averages. The findings support age differences in the amplitudes of the P3 component and suggest that when P3 is not synchronized with a sensory event, latencies in this component may not be sensitive to age differences.
|
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] |
10,000,475
|
Isolating the age deficit in speeded performance.
|
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] |
10,000,476
|
The 'locus' of the age-associated behavioral slowing was investigated with Sternberg's additive-factor method of identifying information processing stages. The factor of adult age was found to interact with manipulations assumed to influence stages concerned with stimulus encoding, internal comparison, and response preparation or execution. Since age appeared to affect each stage of information processing, it was suggested that the age-associated slowing phenomenon is general rather than specific.
|
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] |
10,000,477
|
Sucrose taste thresholds: age-related differences.
|
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] |
10,000,478
|
Sucrose taste detection thresholds were measured in 71 adults aged 20 to 88 years. A forced-choice, tracking procedure was used to eliminate subject response bias and rinses were included between all stimuli. A significant age-related decrease in sensitivity was observed. However, the loss of sensitivity was not great and elderly people had highly variable thresholds. A similar study on salt taste acuity has been reported from this laboratory demonstrating a small, but statistically significant threshold increment with age. The observation that age-related differences in taste sensitivity are not large is consistent with biological information that taste bud cells are continuously replaced in adult mammals.
|
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] |
10,000,479
|
Adult age similarities in free recall output order and strategies.
|
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] |
10,000,480
|
Adult age differences on a variety of free recall measures were examined. Although primary memory capacity was found to be the same in young and old adults, there was a smaller recency effect in the older group. Recall of primacy items was also less for that group. However, the pattern of serial position effects was the same for the two age groups. Similarly, there was no age difference in the development of the strategy of recalling recency items early in the output sequence. Young adults showed the typical negative recency effect in final free recall, and old adults the absence of a positive recency effect. The results indicate that the lower level of recall of old, relative to young, adults cannot be attributed to a qualitative difference in the way the two age groups approach a free recall task.
|
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10,000,481
|
Aging and the picture superiority effect in recall.
|
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-0.03653951361775398
] |
10,000,482
|
One recurrent theme in the literature on aging and memory is that the decline of memory for nonverbal information is steeper than for verbal information. This research compares verbal and visual encoding using the picture superiority effect, the finding that pictures are remembered better than words. In the first experiment, an interaction was found between age and type of material; younger subjects recalled more pictures than words while older subjects did not. However, the overall effect was small and two further experiments were conducted. In both of these experiments, the picture superiority effect was found in both age groups with no interaction. In addition, performing a semantic orienting task had no effect on recall. The finding of a picture superiority effect in older subjects indicates that nonverbal codes can be effectively used by subjects in all age groups to facilitate memory performance.
|
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] |
10,000,483
|
Coding of spatial information by young and elderly adults.
|
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] |
10,000,484
|
Two experiments are reported in which the presumed automatic nature of spatial coding is examined. In Experiment 1, 48 young and 48 elderly female adults, half of each group aware and half unaware of the task requirements, studied 16 cards with four nouns arranged vertically on each card. They were then given these 64 targets, as well as 64 distractors, and were required to sort the targets into one of four input spatial locations and to discard distractors. Awareness of the location requirement had no effect on performance and the two age groups were equivalent with respect to overall spatial memory accuracy. In a second experiment, 40 young and 40 elderly unaware female adults were shown 64 cards with one noun per card in one of four spatial locations. There were no reliable age differences in location performance; the young adults, however, exhibited superior free recall.
|
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] |
10,000,485
|
Estimates of age changes on the Benton Visual Retention Test.
|
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] |
10,000,486
|
Performances on the Benton Visual Retention Test were collected for 894 men 17 to 96 years of age between 1960 and 1976 and were analyzed using slopes to estimate time-of-measurement effects. For each of the nine birth cohorts and eight age groups, performance (errors) was plotted on calendar time. Comparisons of the within-birth-cohort slopes showed an increase in slope with age (rho = 0.92); earlier born (older) cohorts had larger slopes indicating increased errors per year. Comparisons of within-age-group slopes showed no difference among age groups. Slopes of four of the five oldest cohorts were larger (p less than .05) than the common age-group slope. Whether the common age-group slope was a secular effect, a cohort effect, or some combination of the two, the data were consistent with age changes in performance late in life confirming longitudinal results of direct measures of change previously reported.
|
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] |
10,000,487
|
A research and service oriented multilevel assessment instrument.
|
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] |
10,000,488
|
An assessment instrument capable of measuring the wellbeing of the aged in a number of significant domains is described. This Philadelphia Geriatric Center Multilevel Assessment Instrument (MAI) systematically assesses behavioral competence in the domains of health, activities of daily living, cognition, time use, and social interaction and in the sectors of psychological wellbeing and perceived environmental quality. Determination of the psychometric qualities of measures of different length in each of these domains and sectors was made. The performance of 590 older people in groups composed of independent community residents, in-home services clients, and people awaiting admission to an institution was determined. The MAI is seen as useful for both research and for assessment in service-giving situations.
|
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] |
10,000,489
|
Biochemical evidence for the coexistence of monomorphic and polymorphic N-acetyltransferase activities on a common protein in rabbit liver.
|
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] |
10,000,490
|
New Zealand White rabbits were classified as rapid or slow acetylators by measuring the N-acetylation half-life of i.v. administered sulfadiazine, by pedigree analysis and by determination of liver N-acetyltransferase (NAT) activity in vitro. Slow acetylator rabbits were found to have significantly lower levels of p-aminobenzoic acid NAT activity in vitro than did rapid acetylator rabbits, demonstrating genetic covariation of p-aminobenzoic acid (monomorphic) and isoniazid (polymorphic) NAT activity. Monomorphic and polymorphic NAT activities could not be separated by two extensive purification procedures involving sequential centrifugation, fractional precipitation with ammonium sulfate, ion-exchange chromatography on DEAE-cellulose, gel filtration on Sephadex or Sephacryl and isoelectric focusing or electrophoresis on polyacrylamide gels. In addition, indistinguishable heat inactivation patterns were demonstrated for the two NAT activities utilizing highly purified NAT preparations at two different temperatures. Each of these findings support the coexistence of monomorphic and polymorphic NAT activities on a common protein.
|
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] |
10,000,491
|
Inhibition of [3H]norepinephrine uptake in organ cultured rat superior cervical ganglia by xylamine.
|
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10,000,492
|
The superior cervical ganglia (SCG) of the rat, when maintained in organ culture, show an increase in [3H]norepinephrine (NE) uptake in the first 2 days and then a leveling off of this activity through 6 days of culture. The [3H]NE uptake in cultured SCG is Na+ - and temperature-dependent and is inhibited by cocaine, desipramine and benztropine with potencies similar to those reported for uptake inhibition into noradrenergic nerve terminals. The preparation also accumulates [3H]dopamine (DA), but, in contrast to NE and DA uptake in the brain, desipramine and benztropine show no specificity for a particular catecholamine, inhibiting both [3H]NE and [3H]DA uptake with potencies similar to those shown for NE uptake in brain. Thus, observed DA uptake and SCG appears to occur mostly via the NE uptake system, not a specific DA uptake system. Xylamine (N-2-chloroethyl-N-ethyl-2-methylbenzylamine) at 10 microM irreversibly inhibits [3H]NE uptake in cultured SCG by 85% in 30 min, uptake being measured after washing away unbound drug. The IC50 for inhibition is about 0.3 microM. When SCG are again cultured after xylamine exposure, [3H]NE uptake recovers after 2 days. This recovery is partially blocked by cycloheximide, indicating that the synthesis of new uptake sites may be involved.
|
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] |
10,000,493
|
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.
|
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] |
10,000,494
|
Comparison of the behavioral effects of phencyclidine, ketamine, d-amphetamine and morphine in the squirrel monkey.
|
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10,000,495
|
Augmentation by theophylline of [3H]purine release from vascular adrenergic nerves: evidence for presynaptic autoinhibition.
|
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] |
10,000,496
|
The effect of theophylline (a P1-purinoceptor blocker) on the tritium release evoked by high KCl (50 mM) and l-epinephrine (3 microM) was evaluated using [3H]adenosine-prelabeled pulmonary artery of the rabbit. It has previously been shown that KCl elicits purine release from adrenergic nerve terminals whereas epinephrine releases it from postsynaptic sites in this artery. The KCl-induced [3H]purine efflux was significantly enhanced by theophylline (10-100 microM), whereas the efflux induced by epinephrine (3 microM) was not enhanced but reduced by this drug at 100 microM. In contrast to theophylline, 1 to 3 microM adenosine or ATP significantly suppressed the KCl-induced purine efflux. This depolarization-induced efflux was not augmented by 10 microM papaverine or 3 microM phentolamine. Uptake of [3H]adenosine into the pulmonary arterial segment was strongly inhibited by 10 microM dipyridamole or papaverine, but not by the same concentration of theophylline. These findings suggest that the presynaptic autoinhibition mechanism may be involved in the purine release from vascular adrenergic nerves.
|
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10,000,497
|
Effects of dantrolene sodium on the electrophysiological properties of canine cardiac Purkinje fibers.
|
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] |
10,000,498
|
Dantrolene sodium at concentrations between 8.8 and 35.1 microM produced rather selective changes in the electrophysiological properties of isolated dog Purkinje fibers. The action potential duration at 90% repolarization and effective refractory period of normally polarized fibers were increased in a dose- and frequency-dependent fashion. The plateau phase of the action potential was significantly depressed and this effect coincided with a marked decrease in the strength of contraction. Dantrolene sodium had no significant effect on resting membrane potential, upstroke velocity of phase O, conduction velocity or pacemaker activity of Purkinje fibers. Dantrolene diminished or abolished "slow response" action potentials produced by superfusion with 18 mM K+ Tyrode's solution containing 10(-7) M isoproterenol. Drug effects took 10 to 15 min to become apparent, reached a steady-state after 45 to 60 min and were not reversible even after 2 hr of washout with drug-free Tyrode's solution. In contrast, increasing the [Ca++]0 produced nearly a complete reversal of the dantrolene-induced changes. These results suggest that dantrolene produces its effects by interfering with the slow inward current. Thus, dantrolene may be similar in action to other slow channel blocking agents, such as verapamil, and may be useful as an antiarrhythmic agent.
|
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10,000,499
|
Presynaptic effects of tetrahydropapaveroline on striatal dopaminergic neurons.
|
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