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10,000,500 | Coronary arterial vasodilator effect of ibuprofen. | [
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10,000,501 | The effect of ibuprofen, a nonsteroidal anti-inflammatory agent, on coronary vascular resistance in isolated perfused rabbit heart was studied. Ibuprofen had coronary arterial vasodilatory activity. An arterial concentration of 50 microgram/ml produced a half-maximal coronary vasodilator response. An ibuprofen concentr... | [
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10,000,502 | Influence of the dietary potassium intake on the natriuretic effect of hydrochlorothiazide in rats. | [
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10,000,503 | Hydrochlorothiazide (HCTZ)-induced Na requirement was examined in rats fed a standard diet containing 250 mg of HCTZ per kg of food and given a free choice between water and 0.46 M NaCl. HCTZ treatment led to a persistent 8-fold increase of NaCl intake. An increase of the K content of the food from 100 to 600 mmol/kg r... | [
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10,000,504 | Effects of various calmodulin antagonists on contraction of rabbit aortic strips. | [
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10,000,505 | Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine, prenylamine and N2-dansyl-L-arginine-4-t-butylpiperidine amide on vascular smooth muscle contraction were compared by using helically cut strips of rabbit aorta. These compounds are reported to be calmodulin antagonists, in vitro. W-7 ... | [
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10,000,506 | A comparative study of the acute effects of ethanol on the cholinergic system in hippocampus and striatum of inbred mouse strains. | [
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10,000,507 | Postjunctional supersensitivity in young rat heart produced by immunological and chemical sympathectomy. | [
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10,000,508 | Postnatal changes in sensitivity to norepinephrine (NE) were studied in normal and sympathectomized rat hearts. The sensitivity of left atria to NE was highest at birth, after which it declined, reaching the adult level by 2 weeks of age. Developmental changes in NE sensitivity of the left atria seemed to be related to... | [
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10,000,509 | Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of rabbit. | [
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10,000,510 | Isolated circulatory or longitudinally oriented strips from anterior or posterior rabbit bladder base were tested for responsiveness to agonists and sensitivity of field stimulation-induced responses to antagonists. Results were compared to the regional distribution of adrenergic and cholinergic nerves determined histo... | [
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10,000,511 | In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. | [
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10,000,512 | The metabolism and covalent binding of 4-ipomeanol (IPO), a pulmonary toxin, were investigated in pulmonary cells isolated from rabbit. 3H-labeled IPO was incubated with freshly, isolated, intact alveolar type II cells (83% purity), nonciliated bronchiolar epithelial (Clara) cells (77% purity) and alveolar macrophages ... | [
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10,000,513 | Comparative actions of phenytoin and other anticonvulsant drugs on potassium- and veratridine-stimulated calcium uptake in synaptosomes. | [
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10,000,514 | The actions of phenytoin and several anticonvulsants drugs on veratridine-stimulated (Na-dependent) and K-stimulated (Na-independent) Ca uptake were studied in isolated nerve terminals (synaptosomes) from rat cerebral cortex. Phenytoin inhibits both veratridine- and K-induced Ca uptake but is more potent against veratr... | [
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10,000,515 | The kinetics of ethylmorphine N-demethylation in isolated hepatocytes: the effect of drug transport and oxygen concentration. | [
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10,000,516 | In previous studies we have observed that the Km for ethylmorphine N-demethylase was only 50 to 100 microM in the isolated hepatocyte as opposed to 250 to 340 microM in isolated microsomes. These data suggested that either the drug is actively transported into the cell or that the enzymes in the cell had a reduced turn... | [
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10,000,517 | Inhibition of phrenic and sympathetic vasomotor neurons in cats by the serotonin analog 5-methoxy-N,N-dimethyltryptamine. | [
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10,000,518 | 5-Methoxy-N,N-dimethyltryptamine (20-200 microgram/kg) inhibits phrenic and sympathetic neural discharges and depresses blood pressure. The effects occur within seconds after injection. Complete recovery occurs, on the average, after 20 min. The inhibition of phrenic nerve discharges is prevented during hypercapnia and... | [
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10,000,519 | Effect of superior cervical ganglionectomy on the sensitivity of rabbit ear artery and cerebral arteries of rabbit and cat to vasoactive agents. | [
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10,000,520 | The effect of sympathetic denervation on the sensitivity of the rabbit ear and basilar arteries and the cat middle cerebral artery to vasoactive agents was examined in relation to the functional significance of the innervation. Fourteen days after superior cervical ganglionectomy, the catecholamine fluorescence disappe... | [
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10,000,521 | Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. | [
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10,000,522 | The behavioral and physiological effects of L-phenylisopropyladenosine, cyclohexyladenosine and 2-chloroadenosine were examined in mice and rats. These analogs of adenosine are agonists which bind with high affinity to putative central A1 receptors in vitro. Relatively low doses of these drugs administered i.p. produce... | [
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10,000,523 | A unique pharmacogenetic expression of the N-acetylation polymorphism in the inbred hamster. | [
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10,000,524 | Liver N-acetyltransferase (NAT) preparations (105,000 x g cytosol) were obtained from both sexes of 26 strains of inbred hamsters. Liver NAT activity levels were determined for six arylamine substrates; isoniazid, p-aminobenzoic acid (PABA), p-aminosalicylic acid (PAS), sulfamethazine (SMZ), procainamide and 2-aminoflu... | [
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10,000,525 | Comparative accumulation of uric acid and hypoxanthine by slices of avian renal cortex. | [
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10,000,526 | The purpose of the study was to compare the concentrative uptake processes of the 14C-labeled purines uric acid (UA) and hypoxanthine (HX) by slices of chicken renal cortex. It was found that both purines were accumulated by the slices and that, while UA was unaltered metabolically, HX was partially oxidized to UA duri... | [
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10,000,527 | Myocardial disposition and cardiac pharmacodynamics of verapamil in the dog. | [
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10,000,528 | The disposition of verapamil was studied in anesthetized open-chested dogs following administration of intravenous doses of 0.5 mg/kg. The plasma and myocardial verapamil concentration-time data were fit to a three-compartment model to describe the disposition kinetics. The distribution equilibrium between myocardium a... | [
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10,000,529 | Hospital personnel who handle anticancer drugs may face risks. | [
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10,000,530 | Study suggests vaginal hysterectomy is safer. | [
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10,000,531 | The ups and downs of disease rates and sex. | [
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10,000,532 | Cholesterol and cancer. | [
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10,000,533 | Management of acute epiglottitis. | [
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10,000,534 | Timolol-induced bronchospasm. | [
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10,000,535 | Effects of the sauna. | [
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10,000,536 | Lhermitte's sign and cobalamin deficiency. | [
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-0.07155716419219971,
0.028477046638727188,
0.00229... |
10,000,537 | Green urine. | [
-0.02184605970978737,
0.05051139369606972,
0.053114019334316254,
-0.020329967141151428,
0.02786548249423504,
-0.06030265614390373,
0.12249454110860825,
0.05162327364087105,
0.07242982089519501,
-0.033719856292009354,
-0.02921091578900814,
-0.011624160222709179,
-0.018768690526485443,
0.066... |
10,000,538 | The argon laser for cutaneous lesions. | [
-0.030947009101510048,
-0.03503254055976868,
-0.02574833482503891,
0.051224324852228165,
-0.08971856534481049,
-0.08723826706409454,
0.12636514008045197,
0.018470382317900658,
-0.04153132438659668,
-0.01042556669563055,
-0.000005537422111956403,
0.018886661157011986,
-0.024861110374331474,
... |
10,000,539 | Vitamin E. | [
-0.060498595237731934,
0.04624218866229057,
0.026503706350922585,
0.057160116732120514,
0.04678740352392197,
0.020314965397119522,
0.12273957580327988,
0.1011359766125679,
0.025378795340657234,
0.03154663369059563,
0.022803187370300293,
-0.04353411868214607,
-0.03203091770410538,
0.0015571... |
10,000,540 | Adverse reactions to tetanus toxoid. | [
-0.005145497154444456,
0.04163173958659172,
0.028881335631012917,
-0.008473451249301434,
-0.0026897096540778875,
0.011499758809804916,
-0.003025777405127883,
0.1593881994485855,
-0.009539026767015457,
0.05381889268755913,
-0.012454388663172722,
-0.014269858598709106,
0.07137711346149445,
0... |
10,000,541 | A retrospective review of 740 charts of patients with a history of adverse reaction to tetanus toxoid immunization was undertaken. The most common reactions, by history, were local edema and tenderness (33%), fever (15%), and anaphylactoid response (33%). Three patients who had a vesicular eruption at the immunization ... | [
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0.05072686821222305,
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0.015080817975103855,
-0.004555263556540012,
-0.06870368868112564,
0.06508082151412964,
0.06518... |
10,000,542 | Effects of sample selection on the coincidence of hypertension and diabetes. | [
-0.03210139647126198,
0.02158549800515175,
0.0073837279342114925,
0.06682691723108292,
0.08521940559148788,
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-0.008740226738154888,
-0.006455431692302227,
-0.05104772746562958,
-0.051... |
10,000,543 | The occurrence of both hypertension and diabetes in patients at a general medical clinic at a university center and within a work-site community has been determined. In addition, the course of such patients for four years following presentation has been observed. The combination of hypertension and diabetes appeared mo... | [
0.014114152640104294,
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-0.07106366008520126,
-0.003949129022657871,
-0.0316510833799839,
-0.01467405166476965,
0.... |
10,000,544 | Peripatetic plague. | [
0.010304252617061138,
0.06611364334821701,
0.014844338409602642,
0.015267831273376942,
-0.0624157190322876,
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0.04238083213567734,
-0.0032255237456411123,
-0.018397128209471703,
0.02726868912577629,
-0.011443... |
10,000,545 | Cases of plague continue to occur in various parts of the world, including the western United States, where plague is endemic among the wild rodent population. In 1980, a case of plague acquired in New Mexico and hospitalized in Nebraska illustrated the problem of plague occurring in persons traveling from the state in... | [
0.08442419767379761,
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-0.0022517142351716757,
0.015134289860725403,
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0... |
10,000,546 | Aspirin and analgesic nephropathy. | [
-0.006716007832437754,
-0.07310394197702408,
-0.00487173069268465,
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-0.054734911769628525,
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0.03198981285095215,
-0.02729771099984646,
0.05727... |
10,000,547 | To assess the effects of long-term aspirin ingestion on renal function, we studied all of the patients at the Massachusetts General Hospital Arthritis Clinic who had been taking aspirin continuously for ten or more years. Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels. Most of... | [
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0.09257050603628159,
-0.060701884329319,
0.011438914... |
10,000,548 | Acute gouty arthritis. Special management considerations in alcoholic patients. | [
0.036968477070331573,
0.011225378140807152,
-0.039450664073228836,
0.08066092431545258,
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-0.06515902280807495,
0.05226406082510948,
0.10439706593751907,
-0.08314687758684158,
0.071259... |
10,000,549 | Isolation of Mycoplasma hominis from the blood of men with multiple trauma and fever. | [
0.035772908478975296,
0.11902397125959396,
-0.022959275171160698,
0.019510798156261444,
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0.09344951808452606,
0.01571851782500744,
0.003851595800369978,
0.012328657321631908,
0.0074... |
10,000,550 | Ocular myasthenia. Multiple recurrences and spontaneous remissions. | [
0.011462782509624958,
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0.0751565471291542,
0.03402261063456535,
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0.024161526933312416,
0.024037731811404228,
-0.021659111604094505,
0.009093970991671085,
0.074... |
10,000,551 | The safety of treating rheumatoid arthritis with aspirin. | [
-0.08166366815567017,
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0.09302511811256409,
-0.03759709373116493,
-0.00256... |
10,000,552 | Analgesic nephropathy in 1981: which drug is responsible? | [
0.04939740151166916,
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0.10062948614358902,
0.031100885942578316,
0.1... |
10,000,553 | Corneal birefringence. | [
0.03554832562804222,
-0.09522489458322525,
0.06684525310993195,
-0.03624369949102402,
-0.024887975305318832,
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0.08714794367551804,
-0.004011389333754778,
-0.052299864590168,
0.02316... |
10,000,554 | Progressive antral narrowing in an adolescent. | [
0.06722293049097061,
0.03847178444266319,
0.022209428250789642,
0.02377357706427574,
-0.030022671446204185,
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-0.023367775604128838,
0.09336218982934952,
0.09083694219589233,
-0.08607049286365509,
0.0126967... |
10,000,555 | The new wave in medicine: nuclear magnetic resonance. | [
-0.008613402023911476,
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-0.03838009759783745,
0.0004425326478667557,
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0.010485672391951084,
0.0861646980047226,
-0.03131627291440964,
0.0... |
10,000,556 | Women in medicine. | [
0.035829707980155945,
-0.03497393801808357,
-0.041015028953552246,
0.029280783608555794,
-0.04212169349193573,
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0.0028020895551890135,
0.0025637501385062933,
0.028369607403874397,
-0.011831219308078289,
... |
10,000,557 | Computers in medicine. | [
0.003405546071007848,
0.048113156110048294,
0.0269708763808012,
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-0.06086261570453644,
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0.0012674665777012706,
0.11831466108560562,
0.04478000849485397,
0.03337143... |
10,000,558 | Postoperative compressive neuropathies. | [
0.002320290543138981,
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-0.025733543559908867,
0.12366268038749695,
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0.09824477136135101,
-0.013647533021867275,
0.0250... |
10,000,559 | Exposure to cotton dust and respiratory disease. | [
-0.005244457628577948,
0.020167583599686623,
0.045077767223119736,
0.032242052257061005,
0.09118437021970749,
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0.11281568557024002,
0.08941919356584549,
0.02870488353073597,
0.04880106821656227,
0.0616037... |
10,000,560 | Mammographic parenchymal patterns. Risk indicator for breast cancer? | [
0.07808638364076614,
-0.03425154462456703,
-0.06007162109017372,
-0.04812734201550484,
0.008169196546077728,
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0.014288251288235188,
-0.05415811762213707,
-0.01568642631173134,
-0.046... |
10,000,561 | Mammographic parenchymal patterns, originally presented as a new risk factor for breast cancer, have been prospectively studied in a large (27,157 examinations) consecutive screening population. Although there is a significantly higher risk of breast cancer in the so-called dysplastic breasts (P2 and DY pattern groups)... | [
0.06691592931747437,
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0.04139649495482445,
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0.018458712846040726,
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-0.03970419615507126,
0.018336648121476173,
0.05561867728829384,
0.005203531589359045,
-0... |
10,000,562 | Percutaneous radiographically guided catheter drainage of abdominal abscesses. | [
0.0872865617275238,
0.03340911120176315,
-0.03765052184462547,
0.014798229560256004,
-0.0925387591123581,
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0.03666876256465912,
0.10126671940088272,
0.035304583609104156,
-0.03197551891207695,
-0.014220109209418297,
-0.02391083352267742,
0.07321056723594666,
0.13654558... |
10,000,563 | We performed computed body tomography and ultrasound-guided percutaneous catheter drainage in 45 cases of abdominal abscess. Evacuation of the cavity was achieved in 40 cases (89%), eliminating the need for surgery in 34 patients. There were six recurrent abscesses, all due to fistulous communications or recurrent infe... | [
0.08529584109783173,
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0.008391216397285461,
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0.012493632733821869,
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0.02341390773653984,
-0.04673340171575546,
-0.032367005944252014,
-0.008663127198815346,
0.10152152180671692,
0.0997... |
10,000,564 | Rubella antibody persistence after immunization. | [
-0.04308363422751427,
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-0.0603010393679142,
0.028610285371541977,
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-0.028923500329256058,
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0.10031844675540924,
0.0018062638118863106,
0.... |
10,000,565 | A comparative field trial of three live, attenuated rubella virus vaccines (Cendehill, HPV 77 DE-5, and HPV-77 DK-12) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. Following initial seroconversion rates of more than 98%, periodic serological testing of the study population was conduct... | [
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0.022205447778105736,
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0.0047104875557124615,
0.03534626588225365,
0.07418529689311981,
0.032805442810058594,
0.0... |
10,000,566 | Leg ulcer. Conservative management or surgical treatment? | [
0.023192742839455605,
0.033936504274606705,
-0.02824629470705986,
0.04849349707365036,
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0.0401645302772522,
0.08021923154592514,
0.0001370104873785749,
0.0138... |
10,000,567 | In a specific indigent socioeconomic setting, the nonsurgical management of 65 patients with chronic leg ulcers resulted in 59 cures. There were 42 patients (67%) with postphlebitic syndrome. Twenty-two patients (33%) had varicose veins (eight had postoperative vein stripping), 14 (22%) had deep-vein thrombosis, and 11... | [
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0.024708105251193047,
-0.02713160030543804,
0.001617967733182013,
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0.002756053814664483,
0.00858861394226551,
0.1487826555967331,
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0.02951781079173088,
-0.015275889076292515,
-0.000330207752995193,
-0.0... |
10,000,568 | Medical schools, clinical faculty, and community physicians. | [
0.05235891044139862,
0.017496682703495026,
0.057040806859731674,
0.02919354848563671,
-0.0350494310259819,
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0.0664074644446373,
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0.06867996603250504,
-0.04012179747223854,
0.056187305599451065,
-0.07897604256868362,
0.027482315... |
10,000,569 | In vivo comparison of levothyroxine preparations. | [
0.048215169459581375,
-0.09042918682098389,
0.01567872241139412,
-0.07056757062673569,
0.00239507295191288,
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0.021618956699967384,
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0.006195251829922199,
0.006218030583113432,
0.039406247437000275,
0.04918057844042778,
-0.00327... |
10,000,570 | Cefoxitin falsely elevates creatinine levels. | [
-0.025759384036064148,
-0.03388366475701332,
0.036381449550390244,
0.014961456879973412,
0.016493843868374825,
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0.10941942036151886,
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-0.05277999863028526,
-0.022358909249305725,
-0.08338367938995361,
0.07365482300519943,
0.0... |
10,000,571 | Cefoxitin sodium has been found to act like creatinine in assays for creatinine used by many hospitals. Our in vitro results show that cefoxitin causes an apparent rise in the serum creatinine level; the magnitude of the increase depends on the assay method and the concentration of cefoxitin. Results varied from 1.5 to... | [
-0.029549891129136086,
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0.07044928520917892,
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0.020217876881361008,
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-0.056486111134290695,
-0.09925398975610733,
0.06222919002175331,
0.09143... |
10,000,572 | Cough variant asthma in children. | [
0.03681327402591705,
0.01575729250907898,
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0.0012780976248905063,
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0.007058830466121435,
0.08004636317491531,
0.031188679859042168,
0.065... |
10,000,573 | The patient with multiple alloantibodies. One possible answer to meeting blood needs. | [
-0.0017262122128158808,
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-0.033326976001262665,
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-0.031889598816633224,
-0.0015799810644239187,
-0.06502142548561096,
-0.07514189928770065,... |
10,000,574 | Mammographic parenchymal patterns: more controversy. | [
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0.0520564541220665,
-0.017016489058732986,
-0.049952998757362366,
-0.02... |
10,000,575 | Changing patterns of graduate medical education. | [
0.07970742881298065,
0.1005808636546135,
0.04689974710345268,
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0.08640837669372559,
-0.09900379925966263,
0.008862449787... |
10,000,576 | Postgraduate medical education underwent substantial change during the 1970s: medical-school classes grew, the internship year was eliminated, and the numbers of M.D.s entering primary-care specialties increased. The purpose of this study is to develop a planning model of graduate medical education that can project the... | [
0.06638289988040924,
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10,000,577 | Brain death with prolonged somatic survival. | [
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10,000,578 | Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteremia. | [
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10,000,579 | Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 1-1982. A 42-year-old woman with longstanding heart block. | [
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10,000,580 | A QRS scoring system for assessing left ventricular function after myocardial infarction. | [
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10,000,581 | A QRS scoring system for estimating the size of a myocardial infarct was evaluated in 55 patients who did not have left ventricular hypertrophy or conduction abnormalities. Serial 12-lead surface electrocardiograms were scored according to a 29-point system based on the duration of Q and R waves and on the ratios of R-... | [
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10,000,582 | Better service for our overseas subscribers. | [
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10,000,583 | Perils of prophylaxis. | [
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10,000,584 | Aminoglutethimide vs. surgical adrenalectomy in breast cancer. | [
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10,000,585 | Clonidine-suppression test for diagnosis of pheochromocytoma. | [
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10,000,586 | Jogging and suppression of ovulation. | [
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10,000,587 | Autopsy: a further suggestion for its revival. | [
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10,000,588 | Percutaneous catheter drainage of abdominal abscesses. | [
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10,000,589 | Avoiding sphygmomanometer-cuff "hypertension". | [
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10,000,590 | Unsuspected benzyl alcohol hypersensitivity. | [
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10,000,591 | Sputum for cytologic diagnosis of lung cancer. | [
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10,000,592 | Biguanides and the erythrocyte insulin receptor. | [
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10,000,593 | Virus-specific IgE and histamine release in nasopharyngeal secretions. | [
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10,000,594 | Case 35-1981: parainfectious encephalopathy. | [
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10,000,595 | Isolation of Chlamydia trachomatis from the liver capsule in Fitz-Hugh-Curtis syndrome. | [
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10,000,596 | Clinical drug information: a case of misinformation. | [
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10,000,597 | OPEC otitis. | [
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10,000,598 | Health policy report. Health care and American business. | [
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10,000,599 | Hemodynamic characterization of tolerance to long-term hydralazine therapy in severe chronic heart failure. | [
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0.06776003539562225,
... |
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