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Q: Why does my Object become null when going from bean to .xhtml page in jsf I am building a JSF 2.0 Application using primfaces. I have a managed bean that has several objects for different scenarios. In this particular portion of the application I move from a data table/form to a managed bean with an identification number. I pull the information from the database and even have it in the log. However when I make it to the JSF xhtml page the object values are null and I can't seem to figure out why, any help would be great as I am getting no errors, exceptions, or warnings in the logs and all information seems to point to the loading of the data including the log. JSF Page that I am coming from... jobs.xhtml (I am using jsf 2.2 and primefaces to build this application) From this page the link specifies a job number to be retrieved and the next bean will retrieve that job based on the job number I have it down to just a button that will take you to the primary method and get the information to the next page... <?xml version="1.0" encoding="ISO-8859-1" ?> <!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:h="http://java.sun.com/jsf/html" xmlns:f="http://java.sun.com/jsf/core" xmlns:ui="http://java.sun.com/jsf/facelets" xmlns:p="http://primefaces.org/ui"> <body> <div style="margin-bottom:350px;"> <p:column> <h:form> <h:commandButton id="editProject" action="#{editProjects.getProjectForm()}" value="Edit" /> </h:form> </p:column> </div> </body> </html> EditProjects.java the backing bean for the editMailerJob.xhtml which will take in the medium id and the job number the medium id will be used to direct the application to the next page and the job number will be used to retrieve a specific job ::::UPDATED:::: package beans; import java.io.Serializable; import java.text.DateFormat; import java.text.ParseException; import java.text.SimpleDateFormat; import java.util.Date; import javax.faces.bean.ManagedBean; import javax.faces.bean.RequestScoped; import org.apache.commons.logging.Log; import org.apache.commons.logging.LogFactory; import com.RossProjectManagement.rpm.objects.MailerProject; @ManagedBean @RequestScoped public class EditProjects implements Serializable { /** * */ private static final long serialVersionUID = -6680733133634363295L; private final Log LOG = LogFactory.getLog(this.getClass().getName()); // Editable projects private MailerProject edit_mailer = new MailerProject(); //Changed this to be a static set value private String mailerProject = "THIS IS THE MAILER STRING"; public int getProjectForm() { loadEditMailer(); return 1; } public void loadEditMailer() { this.edit_mailer = new MailerProject("REDJ15061005", convertDate("2015-06-29"), false, "RickD", "RickD and the Gang", "new", true, true, "SPEC", 1, 1, 1, "REDJ15061005", "11X17", "SPOT_COLOR", "20,000", convertDate("2015-06-30"), convertDate("2015-07-13"), convertDate("2015-07-06"), convertDate("2015-07-06"), convertDate("2015-07-15"), true, "BDC", "someone@example.com", "STANDARD", 7500.00, "CONQUEST", "NONE", "JS DIRECT", "NONE"); //Commented this out to keep the value static //setMailerProject(edit_mailer.toString()); LOG.debug(":::MAILER PROJECT TO STRING::: " + this.mailerProject); } public Date convertDate(String date) { DateFormat df = new SimpleDateFormat("yyyy-MM-dd"); Date date1 = null; try { date1 = df.parse(date); } catch (ParseException e) { e.printStackTrace(); } return date1; } } JSF page that I am redirecting to editMailerJob.xhtml <?xml version='1.0' encoding='UTF-8' ?> <!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:h="http://java.sun.com/jsf/html" xmlns:f="http://java.sun.com/jsf/core" xmlns:ui="http://java.sun.com/jsf/facelets" xmlns:p="http://primefaces.org/ui"> <body> <div style="margin-bottom: 350px;"> <h:outputLabel>#{editProjects.edit_mailer}</h:outputLabel> <h:outputLabel>Mailer String::: #{editProjects.mailerProject} </h:outputLabel> </div> </body> </html> The log shows that all of the information has been received and loaded but shows no where that the information has been cleaned or the object made anew. I have tried instantiating the object in different places at different times but that didn't work. Before I leave the bean the object has value, when I get to the page the object has no value, I don't understand why I then tried loading the information from different places. I have tried changing the scope of the bean from request to view back to request but no luck, (I thought about doing session but I didn't see the benefit as well as I just couldn't see reasoning to put all of that information into the session). The problem seems to be revolving directly around the bean itself and the getProjectForm Method because at one point the object is loaded and then it just loses all of its information. All of my values seem to be correct as far as I can tell but none of the information is loading. I can't seem to wrap my head around the issue so any help would be greatly appreciated. if any more information is needed just let me know. I hope all of this helps Let me know if I have forgotten anything. EDITS::: I have created just a string to see if at any point it would be delivered either, and so far I am still getting nothing, the .xhtml page is reading that it exists but not that it has value. Still working with this if anyone else has a solution it would be awesome, or if you know the solution and could at the least point me in the right direction that would be great also. UPDATE #2 So I found that if I set the value outside a method it will properly be displayed so it seems to me like the methods are keeping the value from the xhtml page. What is the deal with that, I have getters and setters for the variables I have them declared and defined properly, but for what ever reason the values when loaded by the method are not kept outside the method, the values are not able to be accessed by the xhtml page. 10:00 pm update Found out that if I instantiate the MailerProject object the same way I don't get the same results I still produce an object full of null attribute values. Any ideas guys? A: Start Here - It'll make the rest of this very trivial. The Problem You're using a @RequestScoped bean, and what you're experiencing is the expected behaviour for beans of that scope. Between the first and the second page, you should understand by now, that you're dealing with two different instances of the editProjects bean : a field you set on the first page, backed by one instance of editProjects will not be available on the destination page, backed by a new instance of editBean. To Solve While it wasn't mentioned in the answer I linked to, what you need here is the FlashScope, that serves the express purpose of being transitory in nature: use it just to transport "stuff" between two pages/beans/scopes etc. Sorta. To use: Declare your undying love for the flash scope around the point of origination of the data. In so doing, you're storing your data in the flash scope object, as implicitly provided by JSF, after which you can then navigate away: Flash fScope = FacesContext.getCurrentInstance().getExternalContext().getFlash(); fScope.put("editMailer",edit_mailer); You can then refer to the variable you stored in the flash scope, on the destination page: <h:outputLabel>#{flash.edit_mailer}</h:outputLabel> Like I mentioned earlier, the flash scope is a transitory scope: once the destination page has been rendered and the content of the scope displayed, you can consider the data as good as gone. If you would like to hang on to it for just one page redirect longer, you can specify the keep directive: <h:outputLabel>#{flash.keep.edit_mailer}</h:outputLabel> Unrelated to the problem Avoid doing any heavy lifting in a getter/accessor method (like you're doing in getProjectForm). It's bad for business Why JSF calls getters multiple times Initialization of List in a JSF Managed bean What's the significance of returning "1" from that navigation method? Why not "destination_page", or "edit_page.xhtml", y'know, something easier to read? That's just a style thing anyway, no evil can come of that.
{ "pile_set_name": "StackExchange" }
Sol et Gobelet Sol et Gobelet was a French language children's television show made in Quebec, which was broadcast from 1968 to 1971 on Radio-Canada. Its stories revolved around the adventures of clowns Sol (played by Marc Favreau) and Gobelet (played by Luc Durand). External links emissions.ca: Sol et Gobelet Category:Television series produced in Quebec Category:1960s Canadian children's television series Category:Ici Radio-Canada Télé network shows Category:1968 Canadian television series debuts Category:1971 Canadian television series endings Category:1970s Canadian children's television series Category:Television programs about clowns
{ "pile_set_name": "Wikipedia (en)" }
Background ========== Protein secretion into the extra-cellular environment is one of most desirable strategy to allow a rapid and not expensive recovery of recombinant proteins. Secretion to the culture medium has several advantages over intracellular recombinant protein production. These advantages include simplified downstream processing, enhanced biological activity, higher product stability and solubility, and N-terminal authenticity of the expressed peptide \[[@B1]-[@B3]\]. If the product is secreted to the culture medium, cell disruption is not required for recovery. As bacteria, usually, do not secrete amounts of proteins higher then they have in the intracellular space, recovery of a recombinant gene product can be greatly simplified by a secretion strategy that minimises contamination from host proteins. Additionally, secretion can provide a method to guarantee the N-terminal authenticity of the expressed polypeptide because it often involves the cleavage of a signal sequence \[[@B4]\], thus avoiding the presence of an unwanted initial methionine on a protein that does not normally contain it. This extra methionine can reduce the biological activity and stability of the product \[[@B5]\] or even elicit an immunogenic response in the case of therapeutic proteins. In a previous paper \[[@B6]\], we reported the realization of a \"cold\" recombinant secretion system in the Antarctic Gram-negative bacterium *P. haloplanktis*TAC125. This system efficiently conjugates the obvious advantages of extra-cellular protein targeting with the positive effect of low temperature on the recombinant product solubility. Indeed, low expression temperature can facilitate the correct folding of \"difficult\" products \[[@B7],[@B8]\] and the use of *P. haloplanktis*TAC125 as expression system \[[@B9]\] allowed the efficient production of some \"intractable\" proteins in soluble and active form at temperature as low as 4°C \[[@B10]-[@B12]\]. The cold-adapted secretion system \[[@B6]\] makes use of the psychrophilic α-amylase from *P. haloplanktis*TAB23 \[[@B13],[@B14]\] as secretion carrier. Three chimerical proteins, made of the psychrophilic α-amylase fused to an intra-cellular protein, were translocated in the extra-cellular medium with a secretion yield always higher than 80%. The system also allowed the correct disulphide bond formation of chimera components, secreting a fully active passenger \[[@B6]\]. However, our previous results addressed to a potential limit of this newly set up technology: host extra-cellular medium may contain proteolytic activities which can affect the quality of heterologous products \[[@B6]\]. This feature could hamper the applicability of the cold-adapted secretion system, due to the likely recombinant product degradation. To overcome this host limit, two possible approaches can be pursued thanks to the availability of *P. haloplanktis*TAC125 genome sequencing and annotation \[[@B15]\]: i) the gene disruption of each *P. haloplanktis*TAC125 gene encoding extra-cellular proteases; or ii) the inactivation of the secretion machinery responsible for the proteases extra-cellular targeting. The *in silico*analysis of *P. haloplanktis*TAC125 genome demonstrated that the bacterium possesses only one canonical secretion system, a putative Type II secretion machinery (T2SS) also called General Secretory Pathway (GSP), homologous to GSPs already described in many other Gram-negative bacteria \[[@B16]\]. Since experimental evidences suggested that in *P. haloplanktis*TAC125 the secretion of the cold α-amylase depends on a still uncharacterized pathway (unpublished results from this laboratory), the inactivation of the T2SS machinery seemed a reasonable strategy to develop a *P. haloplanktis*TAC125 mutant strain with reduced extra-cellular proteolytic activity. In this paper we report the set-up of an integrative plasmid and its use for the construction of a *P. haloplanktis*TAC125 strain in which the *gspE*gene \[[@B17],[@B18]\] was knocked-out. This mutation resulted in the inactivation of the psychrophilic T2SS system. The *P. haloplanktis*TAC125 *gspE*mutant displayed a remarkable reduction of the extra-cellular protease secretion, still maintaining its ability to secrete the psychrophilic amylase (the secretion carrier of our recombinant system) as efficiently as the wild type. These features make the *P. haloplanktis*TAC125 *gspE*mutant strain an improved host with a remarkable biotechnological potential in recombinant protein secretion at low temperature. Results ======= *Pseudoalteromonas haloplanktis*TAC125 growth medium contains several secreted proteases ---------------------------------------------------------------------------------------- Wild type *P. haloplanktis*TAC125 cells were grown in TYP medium at 4°C and culture medium samples were withdrawn at different growth phases (at 24, and 32 hours of incubation corresponding to early and medium exponential phase). Concentrated culture supernatants were analyzed for proteolytic activities using Gelatine-SDS-PAGE (10% acrylamide, w/v) as described in Materials and Methods. As shown in Figure [1A](#F1){ref-type="fig"}, the wild type *P. haloplanktis*TAC125 culture supernatants contain a wide range of proteolytic activities, which display an apparent molecular weight ranging between 120 and 33 kDa. ![**In gel analysis of extra-cellular proteolytic activities from culture supernatants of *P. haloplanktis*TAC125 wild type and *gspE*mutant strain**. Panel A: Zymography of *P. haloplanktis*TAC125 wild type culture supernatants collected at early (24 h) (lane 1), and middle (32 h) (lane 2) exponential phase. In this experiment the zymographic developing time was 18 h, a condition that assures the detection of all proteases contained in the sample. Panel B: Protease zymography of a *P. haloplanktis*TAC125 wild type culture supernatant, collected at 24 h, untreated (NONE) and treated with protease inhibitors (10 mM EDTA, 10 mM PMSF, and the combination of the two inhibitors both at 10 mM final concentration). In this experiment a zymographic developing time of 12 h was chosen, this condition allows a clearer visualization and comparison of the proteases contained in the different samples. Panel C: Protease zymography of *P. haloplanktis*TAC125 *gspE*mutant culture supernatants collected at early (24 h) (lane 1), and middle (32 h) (lane 2) exponential phase, the zymographic developing time was 18 h. Panel D: Protease zymography of a *P. haloplanktis*TAC125 *gspE*mutant culture supernatant, collected at 24 h, untreated (NONE) and treated with protease inhibitors, the zymographic developing time was 12 h).](1475-2859-7-2-1){#F1} A protease inhibition assay was performed by treating the 24 hours extra-cellular protein sample with 10 mM PMSF (a serine protease inhibitor) for 20 hours at 15°C, 10 mM EDTA (a metalloprotease inhibitor) for 20 hours at 15°C, and with the combination of the two inhibitors. The differentially treated samples were then subjected to gelatine zymography, and the results are shown in Figure [1B](#F1){ref-type="fig"}. A comparative evaluation of the results demonstrates that the wild type *P. haloplanktis*TAC125 culture supernatant contains extra-cellular proteases inhibited either by PMSF or by EDTA, and proteolytic activities which appear to be resistant to both the inhibitors (Figure [1B](#F1){ref-type="fig"} lane EDTA+PMSF). *Pseudoalteromonas haloplanktis*TAC125 genome encodes a functional Type II protein secretion system --------------------------------------------------------------------------------------------------- Annotation of *P. haloplanktis*TAC125 genome sequence \[[@B15]\] revealed that the psychrophilic bacterium possesses only a canonical extra-cellular protein secretion pathway, i.e. the Type II secretion system (T2SS). The psychrophilic T2SS is located on the larger *P. haloplanktis*TAC125 chromosome and it is made up of twelve genes, from the gene PSHAa0231 to PSHAa0242. The *gsp*gene cluster is likely arranged in several independent transcriptional units, as previously observed in other Gram-negative bacteria \[[@B19],[@B20]\]. Gene expression of *P. haloplanktis*TAC125 T2SS encoding cluster was evaluated by Reverse Transcriptase (RT)-PCR. Total RNA was extracted from cell samples collected at different growth phases, and was used to assess the transcription of *gspE*, *gspC*, and *gspN*. All the tested *gsp*genes resulted to be constitutively expressed in *P. haloplanktis*TAC125 cells (data not shown). Construction and genetic characterization of *Pseudoalteromonas haloplanktis*TAC125 *gspE*mutant strain ------------------------------------------------------------------------------------------------------- Functional inactivation of *P. haloplanktis*TAC125 T2SS system was achieved by insertional mutagenesis of *gspE*gene. This target was selected because it encodes an inner membrane-associated ATP-synthase, which has previously been reported to be essential for the T2SS functioning in other bacteria \[[@B21]\]. Insertional mutagenesis was obtained by using a suicide vector (pVS), suitably constructed for *P. haloplanktis*TAC125. As shown in Figure [2A](#F2){ref-type="fig"}, the pVS vector is characterized by the presence of: i) the pJB3-derived *oriT*\[[@B22]\], a DNA fragment responsible for the initiation of the conjugative transfer between an *Escherichia coli*S17-1 λ*pir*strain (donor) and the psychrophilic cells (acceptor); ii) the *E. coli blaM*gene, encoding a mesophilic β-lactamase which is used as selection gene to isolate the first site-specific integration event; iii) *pheS*^Gly294^, which encodes a mutated version of the *E. coli α*subunit of Phe-tRNA synthase \[[@B23]\], which renders bacteria sensitive to *p-*chlorophenylalanine. This phenylalanine analogue can be used as counterselective agent for the isolation of those strains in which a second recombination event occurred. ![**Schematic representation of pVS suicide vector (panel A) and genetic organization of *P. haloplanktis*TAC125 *gspE*mutant (panel B)**. See text for details.](1475-2859-7-2-2){#F2} Two *gspE*gene fragments were amplified by PCR using specific oligonucleotides as primers. They correspond to two internal gene fragments and they are not adjacent (Figure [2A](#F2){ref-type="fig"}). The fragments were suitably digested and cloned into the pVS vector. The resulting vector (pVS*gspE*) was mobilized into *P. haloplanktis*TAC125, and clones in which a single recombination event occurred were selected on carbenicellin containing solid medium. Genomic DNA from some carbenicellin-resistant clones was extracted and subjected to different PCR analyses, to characterize the occurred genomic insertion. A positive clone was selected for further characterization, and its genome organization is reported in Figure [2B](#F2){ref-type="fig"}. *P. haloplanktis*TAC125::VS*gspE*mutant (hereafter called *P. haloplanktis*TAC125 *gspE*mutant) resulted to contain two copies of *gspE*gene, both carrying a specific deletion that was checked by sequencing the specific PCR products shown in Figure [2B](#F2){ref-type="fig"}. The first copy of *gspE*gene differs from the wild type one in lacking i) the region (450 bp long) between the two amplified fragments and ii) the 3\' encoding region (Figure [2B](#F2){ref-type="fig"}). A transcriptional analysis demonstrated that this *gspE*copy is transcribed (data not shown), but due to the large deletion, the resulting gene contains a translation frame shift leading to the production of an abnormal protein. The other *gspE*gene copy (Figure [2B](#F2){ref-type="fig"}) lacks of its promoter region and of the 5\' encoding portion, and therefore it resulted to be not transcribed (data not shown). *P. haloplanktis*TAC125::VS*gspE*mutant was subjected to *p-*chlorophenylalanine treatment to select a clean deletion mutant. Although the counter-selection was carried out in several experimental conditions, all the selected clones resulted to be meroploid strains, containing both inserted and wild type alleles (data not shown). *Pseudoalteromonas haloplanktis*TAC125 *gspE*mutant strain displays a reduced extra-cellular protease activity -------------------------------------------------------------------------------------------------------------- Growth behaviour of *P. haloplanktis*TAC125 *gspE*mutant strain in standard conditions was determined, and compared with the wild type one. As shown in Figure [3A](#F3){ref-type="fig"}, the *gspE*mutant strain grows faster and makes a higher cellular biomass than the wild type strain. Concentrated culture supernatants of *P. haloplanktis*TAC125 wild type and *gspE*mutant were analyzed by SDS-PAGE and results are shown in Figure [3B](#F3){ref-type="fig"}. The *gspE*mutant culture supernatant contains a reduced number of proteins compared to the wild type. ![**Comparison of *P. haloplanktis*TAC125 wild type and *gspE*mutant growth kinetics and extra-cellular protein contents**. Panel A: growth kinetics of *P. haloplanktis*TAC125 wild type (open circle) and *gspE*mutant (solid square) in TYP medium at 4°C. Panel B: 12% SDS-PAGE analysis of tenfold concentrated culture supernatants of *P. haloplanktis*TAC125 wild type and *gspE*mutant cells grown for 32 hours.](1475-2859-7-2-3){#F3} Extra-cellular protease secretion in *P. haloplanktis*TAC125 *gspE*mutant strain was investigated by gelatine zymography of concentrated culture supernatants. As shown in Figure [1C](#F1){ref-type="fig"}, the samples contain a notably reduced number of proteolytic activities as compared to the protease content of wild type samples (Figure [1A](#F1){ref-type="fig"}) at the corresponding growth phases. Interestingly, the combined EDTA/PMSF treatment resulted in the almost complete inhibition of the extra-cellular proteases secreted by *gspE*mutant (Figure [1D](#F1){ref-type="fig"}). *Pseudoalteromonas haloplanktis*TAC125 *gspE*mutant strain is an improved host for the recombinant protein secretion at low temperature --------------------------------------------------------------------------------------------------------------------------------------- Secretion of psychrophilic α-amylase in *P. haloplanktis*TAC125 *gspE*mutant cells was studied. The mutant strain was transformed with pFC*amy*ΔCt, a psychrophilic vector previously constructed for the recombinant secretion of α-amylase in the Antarctic bacterium \[[@B6]\]. The recombinant mutant strain was grown at 4°C till medium exponential phase and the α-amylase secretion was evaluated by Western blotting analysis of cellular (Figure [4](#F4){ref-type="fig"}, lanes 3) and extra-cellular (Figure [4](#F4){ref-type="fig"}, lanes 4) protein samples. The results demonstrated that the *gspE*mutation does not affect secretion of the psychrophilic enzyme. ![**Psychrophilic α-amylase secretion in *P. haloplanktis*TAC125 *gspE*mutant strain**. Western blotting analysis of extra-cellular media (lane 4) and corresponding cellular extract (lane 3) of *P. haloplanktis*TAC125 *gspE*mutant transformed with pFC*amy*ΔCt plasmid. The western blotting analysis of extra-cellular media (lane 2) and corresponding cellular extract (lane 1) of recombinant *P. haloplanktis*TAC125-(pFC*amy*ΔCt) recombinant cells is shown as a control.](1475-2859-7-2-4){#F4} The secretion of the chimerical protein AmyΔCt-BlaM, made up of the psychrophilic amylase fused to the mature β-lactamase \[[@B6]\], in *P. haloplanktis*TAC125 *gspE*mutant cells was investigated. *P. haloplanktis*TAC125 *gspE*mutant-(pFC*amy*Δ*Ct-blaM*) recombinant cells were grown in TYP medium at 4°C and samples were collected at different growth phases (early, and medium exponential phase). Culture supernatants were analysed by Western blotting analysis using anti-β-lactamase (anti-*Ec*Bla) and anti-α-amylase (anti*Ph*α-Amy) polyclonal antisera, respectively. As shown in Figure [5B](#F5){ref-type="fig"} lanes 3 and 4, both antisera detected a single product, with an apparent molecular weight of 80 kDa, corresponding to the AmyΔCt-BlaM chimerical protein. When a similar analysis was applied to wild type *P. haloplanktis*TAC125-(pFC*amy*Δ*Ct-blaM*) recombinant cells (Figure [5A](#F5){ref-type="fig"} lane 1 and 2), culture supernatants contained either the chimerical protein or its different proteolysis products, i.e. AmyΔCt, BlaM, and a chimera truncated form due to the action of host-encoded secreted proteases on the passenger protein. ![**AmyΔCt-BlaM chimera secretion in *P. haloplanktis*TAC125 wild type and *gspE mutant***. Panel A: Western blotting analyses of extra-cellular media of *P. haloplanktis*TAC125(pFC*amy*ΔCt-*blaM*) recombinant cells. Samples were collected during the early (24 h) (lane 1), and middle (32 h) (lane 2) exponential phase. Immunodetection was performed by chemioluminescence after probing proteins with anti-α-amylase (anti-*Ph*α-Amy) and anti-β-lactamase (anti-*Ec*Bla) polyclonal antisera. Panel B: Western blotting analyses of extra-cellular media of *P. haloplanktis*TAC125 *gspE*mutant-(pFC*amy*Δ*Ct*-*blaM*) recombinant cells. Samples were collected during the early (24 h) (lane 3), and middle (32 h) (lane 4) exponential phase. The immunodetections were performed by using anti-α-amylase (anti-*Ph*α-Amy) and anti-β-lactamase (anti-*Ec*Bla) polyclonal antisera.](1475-2859-7-2-5){#F5} Discussion ========== In a previous paper \[[@B6]\], we reported the establishing of a versatile gene-expression system for secretion of heterologous proteins in *P. haloplanktis*TAC125. The system uses the psychrophilic α-amylase from *P. haloplanktis*TAB23 as secretion carrier, and allows an efficient extra-cellular addressing of recombinant proteins. However, we realized that the system efficiency was hampered by the presence of host-encoded extra-cellular proteolytic activities \[[@B6]\]. The presence of extra-cellular proteases represents a severe limit to the use of any genetic system for the recombinant protein secretion, since host-encoded proteases can affect the quality of the heterologous secreted products. To enhance the recombinant product quality and stability, we focused our attention on the extra-cellular proteases produced by the psychrophilic *P. haloplanktis*TAC125 with the aim of developing a host mutant strain with reduced extra-cellular proteolytic activity. By in gel activity assay, we demonstrated that several proteases are present in the culture medium of the psychrophilic bacterium (Figure [1A](#F1){ref-type="fig"}). The zymographies presented in Figure [1](#F1){ref-type="fig"} did not allow us to define the exact number of extra-cellular proteases, due to the low resolution of this experimental technique. However, the inhibition assay allowed us to explore at least the diversity in the action mechanisms of the psychrophilic extra-cellular proteases. Indeed, metalloproteases, serine proteases and enzymes belonging to different classes were detected (Figure [1B](#F1){ref-type="fig"}). Considering the multiplicity and heterogeneity of proteases detected in *P. haloplanktis*TAC125 culture medium, the systematic disruption of each extra-cellular protease encoding gene appears a time-consuming strategy. Therefore, we decided to inactivate the molecular machinery responsible for the extra-cellular targeting of proteases. This aim was achieved combining some information deriving from the *in silico*analysis of *P. haloplanktis*TAC125 genome with several experimental evidences. In particular, from the accurate genome annotation, it was known that the psychrophilic bacterium possesses only one canonical secretion machinery (the T2SS pathway), while we have collected evidences indicating that the psychrophilic α-amylase (the secretion carrier of our recombinant system) is likely secreted by another secretion apparatus not yet fully characterized (unpublished results from this laboratory). Thus, the functional inactivation of *P. haloplanktis*TAC125 T2SS seemed a feasible approach to generate a psychrophilic mutant strain possibly secreting a lower protease amount but still able to secrete the recombinant α-amylase and its chimerical derivates. T2SS (also called General Secretory Pathway) is a multi-component machinery encoded by the *gsp*cluster and promoting secretion of Sec- and Tat-dependent exo-enzymes in a two-step process \[[@B16],[@B19],[@B20]\]. Our results demonstrated that the *P. haloplanktis*TAC125 *gsp*gene cluster is actually transcribed and that the *gsp*genes expression seems to be constitutive over the bacterial growth (data not shown). Therefore it was necessary to use a genetic approach aimed at completely abolishing *gsp*-dependent secretion during all growth phases. *gspE*Gene \[[@B17],[@B18]\] encodes a specialized ATP-synthase whose inactivation resulted in the total loss of T2SS functionality in other Gram-negative bacteria \[[@B21],[@B24],[@B25]\]. Therefore the psychrophilic *gspE*gene was selected as target for inactivation by insertional mutagenesis. The *P. haloplanktis*TAC125 *gspE*mutant strain was constructed by applying a typical gene targeting strategy, which makes use of a suitably constructed psychrophilic suicide vector (Figure [2A](#F2){ref-type="fig"}). As described in result section, this mutagenesis strategy allowed the creation of a *P. haloplanktis*TAC125 mutant strain characterized by the absence of GspE function. A preliminary phenotypic analysis, carried out in standard growth conditions, demonstrated that *P. haloplanktis*TAC125 *gspE*mutant displays specific growth rate and biomass productivity higher than the wild type strain, thus surprisingly the mutation does not affect but improve the bacterium fitness (Figure [3A](#F3){ref-type="fig"}). This observed *gspE*mutant behaviour could be justified considering that *gsp*-dependent protein secretion is a high costly metabolic process, and its inhibition may represent an advantage to *gspE*mutant strain, at least in the tested growth condition. The analysis of the extra-cellular protein content demonstrated that *gspE*mutant actually secretes lower amounts of proteins with respect to the wild type strain (Figure [3B](#F3){ref-type="fig"}). Proteins secreted by the *gspE*mutant are translocated by secretion pathways different from T2SS, such as the specialized machineries for type IV pili and curli components secretion \[[@B15]\] and the secretion apparatus responsible for the recombinant α-amylase secretion (unpublished results from this laboratory). Zymographic analysis revealed that the *gspE*mutant strain medium contains a notably reduced number of proteolytic activities (Figure [1C](#F1){ref-type="fig"}) with respect to wild type culture supernatants (Figure [1A](#F1){ref-type="fig"}). In contrast, knocking out of *gspE*gene did not impair for secretion of the cold-adapted amylase (Figure [4](#F4){ref-type="fig"}). In fact, *P. haloplanktis*TAC125 wild type and *gspE*mutant strains resulted to be indistinguishable in terms of cold-adapted α-amylase production and secretion yields. The *gspE*mutant was further tested for its ability to secrete a α-amylase chimerical product, the AmyΔCt-BlaM chimera. When produced by wild type cells, the chimera components (i.e. the psychrophilic α-amylase and the mesophilic β-lactamase) (Figure [5A](#F5){ref-type="fig"}, lanes 1 and 2) are partially separated due to the sub-stoichiometric proteolytic cleavage of the linker which connects the two proteins (see also \[[@B6]\]). This processing does not affect the catalytic activity of each component of the chimera \[[@B6]\]. The host-encoded secreted proteases are also responsible for further chimera degradation (see \"chimera truncated form\" in figure [5A](#F5){ref-type="fig"}, lanes 1 and 2) which accounts for the previously reported and undesired decrease of passenger activity \[[@B6]\]. On the contrary, due to the reduced number of extra-cellular proteases present in culture medium, AmyΔCt-BlaM chimera accumulates as a unique unprocessed form when produced in *P. haloplanktis*TAC125 *gspE*mutant cells (Figure [5B](#F5){ref-type="fig"}, lanes 3 and 4), thus resulting in an enhancement of chimera quality over the whole production process. Conclusion ========== Combining the experimental evidences we collected on the α-amylase secretion machinery in *P. haloplanktis*TAC125 with the careful *in silico*analysis of its genome, we designed an simple and successful experimental approach for the construction of an improved psychrophilic host for the cold α-amylase-dependent recombinant secretion system. In fact, by a single gene disruption, involving the psychrophilic *gspE*gene, we developed a *P. haloplanktis*TAC125 mutant strain which secretes a significantly reduced extra-cellular protease activity while keeping its ability to secrete the recombinant psychrophilic α-amylase as the wild type strain. The *gspE*mutant strain is also characterized by specific growth rate and biomass productivity higher than wild type strain, making it a truly improved host with a remarkable biotechnological potential in recombinant protein secretion at low temperature. Moreover, this work demonstrates that *P. haloplanktis*TAC125 is a versatile psychrophilic host for recombinant protein production since it that can be easily improved by a directed engineering approach. To the best of our knowledge, this is the first described example of a strain improvement strategy applied to an Antarctic bacterium. Methods ======= Strains and plasmids -------------------- *P. haloplanktis*TAC125 was isolated from Antarctic sea water \[[@B15]\]. *Escherichia coli*DH5α \[[@B26]\] was used as host for the gene cloning. *E. coli*strain S17-1(λ*pir*) was used as donor in interspecific conjugation experiments \[[@B27]\]. Growth conditions and analytical procedures ------------------------------------------- *P. haloplanktis*TAC125 was grown in aerobic conditions at 4°C in TYP broth (16 gr/L yeast extract, 16 gr/L bacto tryptone, 10 gr/L marine mix) at pH 7.5, supplemented with ampicillin 200 μg/ml, chloramphenicol 25 μg/ml, or cabenicellin 30 μg/ml, when required. Antarctic bacteria transformation was achieved by intergeneric conjugation as previously reported \[[@B9]\]. *E. coli*cells were routinely grown in Terrific broth \[[@B28]\] at 37°C. When required, antibiotics were added at the following concentrations in liquid cultures: 100 μg/ml of ampicillin, or cloramphenicol at 50 μg/ml final concentration. Genetic manipulations were carried out following standard procedures \[[@B28]\]. *P. haloplanktis*TAC125 DNA genomic purification was performed by ChargeSwitch gDNA Mini Bacteria Kit (Invitrogen). Protein samples were analyzed by Polyacrylamide Gel Electrophoresis (Sodium Dodecyl Sulphate-PAGE) (12% acrylamide, w/v) according to standard methods \[[@B28]\]. For immunoblotting, the proteins were transferred to a polyvinylidene difluoride membrane (Immobilon PSQ, Millipore). For immunodetection of proteins, *P. haloplanktis*TAB23 anti-α-amylase \[[@B29]\] or anti-β-lactamase antisera were diluted in blocking buffer (phosphate buffer saline; 5% skimmed milk). Peroxidase conjugate anti-rabbit IgG (Sigma-Aldrich, USA) was used as secondary antibody. Proteins were detected by chemiluminescence\'s (Pierce, USA). Construction of suicide insertion vector pVS*gspE* -------------------------------------------------- pVS suicide vector was constructed by the insertion of the pJB3-derived *oriT*\[[@B22]\] and *pheS*^Gly294^gene \[[@B23]\] into the pGEM7Z vector. The *oriT*, responsible for the initiation of the conjugative transfer, was amplified on pJB3 vector by using Oligo oriTEcoRIfw and Oligo oriTSacIrv as primers (see Table [1](#T1){ref-type="table"}), and was cloned into *EcoRI*and *SacI*sites of pGEM7Z (pGEM7Z-OriT). *pheS*^Gly294^gene, which encodes a mutated version of the *E. coli α*subunit of Phe-tRNA synthase, was amplified using pKSS \[[@B23]\] vector as template. The PCR reaction was carried out using the oligonucleotide pair PheSSNfw and PheSXrv, designed to introduce *Nde*I and *Xba*I restriction sites. The amplified DNA fragment was subjected to double *Nde*I/*Xba*I digestion and cloned into pPM13 plasmid \[[@B11]\] corresponding sites generating pPM13-*pheS*^Gly294^vector. The DNA fragment, containing P13 promoter and *pheS*^Gly294^gene, was recovered from pPM13-*pheS*^Gly294^vector by *SmaI/EcoRI*digestion, filled in and cloned into the pGEM7Z-*oriT NaeI*restriction site, resulting in the construction of the pVS vector. ###### Plasmids and oligonucleotides used in this work *Plasmids* --------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------- pFC Psychrophilic gene-expression vector, containing the T/R box, the promoter and termination region of the *P. haloplanktis*TAC125 *asp*C gene and the chloramphenicol resistance gene \[6\] pFC*amy*ΔCt pFC containing a truncated version of the *amy*gene devoid of the C-terminal propeptide encoding portion \[6\] pFC*amy*ΔCt-*blaM* pFC containing the *amy*ΔCt-*blaM*gene encoding the chimerical protein Amy-BlaM \[6\] pVS pGEM7Z vector containing a conjugation transfer origin (oriT), the counter selectable marker pheS ^Gly294^and the ampicillin resistance gene This work *Oligonucleotides* Oligo oriT*Eco*RIfw 5\'-TTGAATTCTCGCACGATATACAGG-3\' Oligo oriT*Sac*Irv 5\'-AAGAGCTCTTGAAGACGAAAGGG-3\' Oligo gspE*Sph*Ifw 5\'-TTGCATGCATGCGCATCATCCGG-3\' Oligo gspE*Sac*Irv 5\'-AAGAGCTCCAATATCGAGCTTAGCC-3\' Oligo gspE*Sac*Ifw 5\'-TTGAGCTCCTAAAGTAGGTATGACC-3\' Oligo gspE*Eco*RIrv 5\'-AAGAATTCGTACACGGGCTACAGCC-3\' Oligo gspESrv 5\'-AAGAGCTCCTTCACTGAGCATCG-3\' Oligo gspEfw 5\'-GCAATTTAAGCAGCGCGAAGATG-3\' Oligo gspErv 5\'-ATCTAGGGCACGGTATTCAAATGC-3\' PheSSNfw 5\'-TTGTCGACATATGTCACATCTCGCAGAAC-3\' PheSXrv 5\'-CCTCTAGAGAATTTCATAATCTATTCCTGCC-3\' Two DNA fragments of *P. haloplanktis*TAC125 *gspE*gene were amplified by PCR using bacterial genomic DNA as template. Two primer pairs were designed to amplify a 567 bp region at the 5\' end (Oligo gspE*Sph*Ifw, Oligo gspE*Sac*Irv) and a 621 bp region at the 3\' (Oligo gspE*Sac*Ifw, Oligo gspE*Eco*RIrv) end of the *gspE*gene. The amplified DNA fragments were digested by *SphI/SacI*and *EcoRI/SacI*and cloned into the pVS *Sph*I/*Eco*RI site to generate the pVS*gspE*vector. The resulting vector was mobilized by intergeneric conjugation \[[@B9]\] into *P. haloplanktis*TAC125, and the cells were plated at 4°C on TYP solid medium containing 30 μg/ml carbenicellin to select those clones in which a single recombination event occurred. All PCR amplifications were performed in standard conditions \[[@B28]\]. The amplified fragments were cloned and their nucleotide sequences were checked to rule out the occurrence of any mutation during synthesis. Zymographic assay ----------------- *P. haloplanktis*TAC125 wild type and *gspE*mutant strains were grown in standard conditions and culture samples were collected at different growth phases as reported in the text. Samples were centrifuged at 10000 × *g*for 5 min at 4°C and the upper phase was collected for further analysis. The collected culture media were tenfold concentrated by Centricon (AMICON, exclusion size 5 kDa), and 12 μl were loaded onto a non reducing SDS-PAGE containing gelatine (1.5 mg ml^-1^). After electrophoresis, gel was soaked twice with 2.5% Triton X-100 (v/v) solution for a total of 60 min to remove SDS. The gel was then incubated in a developing buffer (50 mM Tris-HCl, pH 7.5, containing 5 mM CaCl~2~) for 12 or 18 (as indicated) hours at 15°C, rinsed with water, and stained with Coomassie blue R250. Areas of gelatine digestion, corresponding to proteolytic activities, were visualized as unstained regions in the gel. Protease inhibition assay ------------------------- Tenfold concentrated culture supernatants of *P. haloplanktis*TAC125 wild type and *gspE*^-^mutant cells were incubated with no inhibitors, or 10 mM EDTA, or 10 mM PMSF, or a combination of EDTA and PMSF (both at 10 mM final concentration) at 15°C for 20 hours. The samples were then subjected to protease zymographic assay. Authors\' contributions ======================= DDV and CC performed the experiments and helped to draft the manuscript. EP and MLT drafted the manuscript and designed and coordinated the study. All authors read and approved the manuscript Acknowledgements ================ We are grateful to Dr. Gerard Michel (LISM/IBSM CNRS 31 Chemin J. Aiguier 13402 Marseille) for critical reading of the manuscript and very helpful discussions. This work was supported by grants of Ministero dell\'Università e della Ricerca Scientifica (Progetti di Rilevante Interesse Nazionale 2006) and of Programma Nazionale di Ricerche in Antartide 2004.
{ "pile_set_name": "PubMed Central" }
Beat Wyss Beat Wyss (1947 in Basle) is a Swiss art historian, professor ordinarius for art history and media theory at Karlsruhe University of Arts and Design, Germany, and member of the Heidelberg Academy of Sciences and Humanities. Life Beat Wyss studied art history, philosophy and German literature at the University of Zurich, where he served as assistant lecturer. In 1980, he was awarded a three-year grant by the Swiss National Fund for research stays at the Free University of Berlin (FU) and at the Istituto Svizzero di Roma. From 1986 to 1989 he worked as an editor for the publishing house Artemis (Zurich/Munich) and taught history of architecture and cultural history at the Swiss Federal Institute of Technology Zurich (ETH). After a visiting professorship at Bonn University and a scholarship at the Getty Center in Santa Monica, Wyss was appointed professor for art history by Ruhr University Bochum in 1990. Following a visiting professorship at Cornell University, Ithaca, N.Y., in 1996, he was appointed ordinarius for art history by Stuttgart University in 1997. In 1999, he was visiting professor at Aarhus University, Denmark. In 2001, Wyss was awarded the Art Price of the city of Lucerne. Since 2004 he has been holding the chair in art history and media theory at Karlsruhe University of Arts and Design, where he also served as speaker of the Graduate School „Bild – Körper – Medium“ (Image – Body -Medium) from 2003 to 2009. From 2008 to 2011 he was professorial fellow at the Swiss Institute for Art Research (SIK-ISEA) in Zurich.Kleinhünigen. Salient Publications Renaissance als Kulturtechnik. Philo Fine Arts, Hamburg 2013. Die Pariser Weltausstellung 1889. Bilder von der Globalisierung. Insel, Frankfurt am Main 2010. Nach den großen Erzählungen. Suhrkamp, Frankfurt am Main 2009. Die Wiederkehr des Neuen. Philo & PhiloFineArts / Europäische Verlagsanstalt, Hamburg 2007. Vom Bild zum Kunstsystem. 2 volumes, Verlag der Buchhandlung Walther König, Cologne 2006. Die Welt als T-Shirt. Zu Ästhetik und Geschichte der Medien. DuMont, Cologne 1997. Der Wille zur Kunst. Zur ästhetischen Mentalität der Moderne, DuMont, Cologne 1996. Spanish translation: La voluntad de arte. Madrid 2010. Trauer der Vollendung. Zur Geburt der Kulturkritik. Matthes & Seitz, Munich 1985. reprint: DuMont, Cologne 1997. English translation (by Karoline Dobson Saltzwedel): Hegel's Art History and the Critique of Modernity.'' Cambridge University Press, New York 1999. References External links short biography and selected publications of Beat Wyss on the website of Karlsruhe University of Arts and Design Category:1947 births Category:Living people
{ "pile_set_name": "Wikipedia (en)" }
Effects of adrenaline-tablets on rat heart cells in tissue culture at normal and raised temperature. Primary cultures of rat heart cells were incubated at 37 degrees C or 39.5 degrees C. For permanent treatment with adrenaline recently developed tablets were added to the cultures. After 10 hours the cell counts, glucose, lactate, LDH, alpha-HBDH and GOT were determined. Permanent adrenaline-application led to a decrease of cell counts, an increase of lactate, LDH, alpha-HBDH and GOT. The results indicate an injured membrane function of rat heart cells. Raised temperature sensitized the cells for adrenaline-treatment.
{ "pile_set_name": "PubMed Abstracts" }
ADVERTISEMENT New Tag Team Championship Design Coming Soon The WWE recently debuted the Women’s Tag Team Championship, which were crowned last Sunday at Elimination Chamber. The WWE’s original plans for the titles were reportedly similar to the Men’s “penny” design, but was scrapped due to the company not liking the final product. When leaked designs of the Women’s Tag Team Titles were first revealed at the beginning of the year, Belt insider Belt Fan Dan revealed that the RAW and Smackdown Men’s Titles would receive a change as well. The initial thought was the change would only be removable side plates, but it now seems like a whole new design is coming. Dan recently stated that the Men’s Tag Team Titles are set to get receive a facelift , and the company has contracted world famous belt designs Dave McMillan to design new RAW and Smackdown Tag Team Titles. Dave McMillan designed the original “penny style” titles which debuted in 2010. The copper titles were eventually made brand specific for RAW and Smackdown following the brand split in 2016. Recently, Dash Wilder posted on Twitter that he would like to see the throwback tag team title design that was used by the company from 1983 – 2002. It is unknown if the company plans on re-introducing that design.
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Covers every aspect of Youth, Virtually. A voice that never ages... Phenomenal songs for over 3 decades... Soulful, youthful and romantic melodies... Backing a range of actors... Adding taste to ordinary characters... 5 Filmfares for the Best Playback Singer... He is non other than... Udit Narayan... The voice of the era...SILVER BELLS AT CH&FC GROUNDSBy Mandulee Mendis Harmonious melodies mingled with Indian beat filled the air of CH & FC grounds on 16 th night. The long awaited concert commenced at 7 p.m. with a fascinating dance performed to some Bollywood hits and the dancers included famous Sri Lankan stars Roshan Ranawana, Shalini Tharaka, Suraj Mapa, Akalanka Ganegama and Shashila. Glamour was sprinkled on the audience with the first song of the star of the night: Udit Narayan. It was a blast! The thrill sustained the same till the end until he came out with all his songs followed by few other stars specially including his wife Deepa Narayan. The stage gleamed more, with the splendor and the fascination of local dancers and Bollywood dances added glitter to it. The concert that prolonged till 11.30 p.m. was an obvious success and it was a tremendous work of 20 days which included complete preparation and swift promotion. Everyone could see with a sense of awe, the admirable work of the organizers :specifically Balcony 6 Entertainment, Sandaruwan Thenuwara, Carmen Thenuwara and Gayan Thenuwara ; the sound suppliers: Malinda Lowe (Universal Sounds), Stage lighting: MOS Pvt. Ltd and the promoters specially including MBC networks. On behalf of the organizers, Xtream youth thank each and everyone who did the duties to the best of their ability since 15th June morning when Udit Narayan stepped here in Sri Lanka, during the press conference at Taj Samudra hotel that evening, and during the climax: the magnificent concert which was an apparent success.
{ "pile_set_name": "Pile-CC" }
August 9, 2016 Happy Monday everyone! Not sure about you, but right now I’m loving all the blues and navy’s! It really feels like a neutral to me right now, I catch myself adding a bit of blue here and a bit of blue there. That includes fashion and decorative pieces for my home too! If you love whites and that airy aesthetic, then I think you might just like to add in some of those blues hues! And for that matter, it’s forever classic! -SHOP THE POST- JavaScript is currently disabled in this browser. Reactivate it to view this content.
{ "pile_set_name": "Pile-CC" }
Interdependence of the actin and the microtubule cytoskeleton during fungal growth. Cell polarization is a theme in biology conserved from bacteria to man. One of the most extremely polarized cells in nature is the hyphae of filamentous fungi. A continuous flow of secretion vesicles from the hyphal cell body to the tip is essential for cell wall and membrane extension. Microtubules (MTs) and actin, along with their corresponding motor proteins, are involved in the secretion process. Therefore, the arrangement of the cytoskeleton is a crucial step to establish and maintain polarity. Here we review recent findings unraveling the mechanism of polarized growth with special emphasis on the role of the actin and MT cytoskeletons and cell end markers linking the two cytoskeletons. We will mainly focus on Neurospora crassa and Aspergillus nidulans as model organisms.
{ "pile_set_name": "PubMed Abstracts" }
Zahra Wadood Fatemi Zahra Wadood Fatemi () is a Pakistani politician who has been a member of the National Assembly of Pakistan, since August 2018. Previously she was a member of the National Assembly from June 2013 to May 2018. Political career She was elected to the National Assembly of Pakistan as a candidate of Pakistan Muslim League (N) (PML-N) on a seat reserved for women from Punjab in the 2013 Pakistani general election. She was re-elected to the National Assembly as a candidate of PML-N on a seat reserved for women from Punjab in the 2018 Pakistani general election. Personal life She is a social worker and is married to Tariq Fatemi. References Category:Living people Category:Pakistan Muslim League (N) MNAs Category:Punjabi people Category:Pakistani MNAs 2013–2018 Category:Women members of the National Assembly of Pakistan Category:Year of birth missing (living people) Category:Pakistani MNAs 2018–2023
{ "pile_set_name": "Wikipedia (en)" }
諏訪大社の大祝(おおほうり)をつかさどった諏訪氏は、代々諏訪大社の神官を務め、平安時代から武士としても活躍してきた。大祝とは、いわば神官のトップであり、現実社会でも権勢を誇った諏訪氏は、領主としてもこの地に長く君臨してきた。 諏訪頼忠(よりただ)は、少年時代にいとこであり諏訪氏の当主だった兄・頼重が武田信玄に謀殺されるという悲劇に見舞われた。父の満隣(みつちか)とともに、国を追われるように各地を転々と放浪した後、諏訪上社の大祝の地位につけられた。信玄は諏訪大社を崇拝しており、諏訪氏の血を引く頼忠を大祝につかせ、祭祀(さいし)を継続させたかったとみられている。 以降は信玄に仕える立場で、神官の務めを果たした頼忠だったが、心中ではひそかに権力者としての諏訪氏再興の野望を抱いていたらしい。ただ、全盛期の信玄に対して謀反を起こす暴挙はさすがにしなかった。やがて信玄が病に倒れ、後継者の勝頼も織田信長に敗れて武田氏が滅亡する。勝頼の母は諏訪頼重の母で、頼忠とも血縁関係にあったわけだが、頼忠にとっては雌伏40年の時を経て、ついに訪れた諏訪氏再興のチャンスであった。 そして本能寺の変で織田信長が倒れると、頼忠は諏訪氏旧臣を集めて織田側の代官を追い払い、領主の座に復帰して高島城に入城した。だが、悲願を達成したのもつかの間、旧武田領を狙う徳川家康と北条氏政の軍勢が信濃を襲う。頼忠は、当初は北条方に属して徳川に対抗したが、大勢が徳川有利に傾くや家康に接近。本領安堵(あんど)を条件に家康の軍門に下ったのである。 その後の頼忠は家康に仕えて必死に戦った。徳川勢の中では新参者に過ぎないため、懸命にアピールするほかなかったのだ。戦場でも活躍したが、家康は秀吉によって関東への移封を命じられたのである。頼忠もまた、徳川の家臣として住み慣れた諏訪の地を離れ、武蔵国に1万2000石を与えられた。 しかし、関ヶ原の戦いで、頼忠が江戸城の留守居役を務め、嫡男の頼水が上田城攻めに参戦すると、戦後に与えられたのは諏訪の高島城であった。家康は諏訪父子の忠誠心を試し、その期待に十分応えたとみて、旧領復帰という粋なプレゼントをしたのである。 その後、諏訪氏は代々譜代大名として徳川家に尽くした。9代藩主・忠誠の代には老中に任じられるという名誉も担っている。すべては、中興の祖として頑張った頼忠の功績だろう。その証拠に、諏訪家の通字として代々名乗った「頼」の字に変わり、その子孫は代々「忠」の字を名乗るようになっている。 (渡辺敏樹/原案・エクスナレッジ)
{ "pile_set_name": "OpenWebText2" }
lexer grammar t001lexer; options { language = Python3; } ZERO: '0';
{ "pile_set_name": "Github" }
# Flickr This folder contains the extension implementation for the [Flickr](https://www.flickr.com) service. The implementation is based off of [Flickr4Java](https://github.com/boncey/Flickr4Java). ## Data Supported - [Photos](src/main/java/org/datatransferproject/datatransfer/flickr/photos) Import & Export ## Current State No known issues, however like much of DTP still needs some in depth testing to ensure corner cases are working. ## Keys & Auth Apply for a key at [www.flickr.com/services/apps/create/apply](https://www.flickr.com/services/apps/create/apply) Flickr uses OAuth 1.0 for authorization. ## Maintained By The Flickr extension was created by the [DTP maintainers](mailto:portability-maintainers@googlegroups.com) and is not an official product of Flickr.
{ "pile_set_name": "Github" }
An Introduction To Interior Paintings Designs And Paints This All About Interior Design information will guide you about the most appropriate options available in Interior Painting Designs, paints and colors, you should tutor yourself on the basics used in interior paints because the colors and paints used for interior are not the same used outside. The paints used to cover the exterior of the house have more resistant power against moisture and harsh climatic conditions. The paints used outside have more concentration of pigments to prevent an early fading of the shine and they can withstand weathering effects for a longer period. Paints used inside are diverse in nature and colors suiting different forms of surfaces, so it very crucial to put the right paints on the appropriate surface for everlasting finish. Interior Painting Designs and colors are selected on the basis of area and the function the paint is used for, as the options are many so both should complement each other. Paints rich in gloss and resin should be applied on surfaces where there are heavy movements like kitchen, passage ways, car parks and utility rooms. They become hard when dry and do not dress out easily. Such paints look good because of giving shine and gloss and make the space look fabulous even in dark tones. Latex paints are best for use on stones, rocks and brick walls as they are water base paints and can smash up wood walls and iron works. These paints give a very fine result when used on walls already painted with heavy gloss paints. For rustic and matte looks rubber paints can be used. They are very durable, easily cleaned and sustained. They are well-suited on bricks, stone and clay walls. For ceilings paints with low concentration of resin are used because ceilings are usually not touched and they do not undergo scratches. Interior paintings designs and patterns are made on walls and ceilings by special texture paints. Texture paints are of two types, alkyd and latex paints. To give walls different textures paints with sand particles are sprayed so that it gives embossed textures to the walls. Wood is a difficult material to paint and suits with oil based paints like alkyd paints. Alkyd paints can be used to cover all types of wood surface and walls layered with primers. Bathroom also needs special considerations and points to focus before painting and more important is the type you choose not the color. The inside of the bathroom has a high percentage of moisture and steam and provides home to many types of moulds and fungus. Therefore it is obvious to select the paint which is water repulsive and does allow the growth of moulds. The most excellent types easily available in the market are shades of “interior latex with mildew inhibitors.” The shade of color should depend on the size of bathroom, if the bathroom is small in size and to give it spacious look go for light pastels in the background and decorate it with darker color splashes or designs on it. If the bathroom is tiled than even the paint should also match with it. 0 comments: Note: Only a member of this blog may post a comment. Several ways to have Tropical Living Room Do you just want to escape somewhere living in a typical past way? Do you want to get into the lives of traditional tribe where there would be the tropical climate? Sounds interesting, isn’t it? If it so then you should take care of many things. You should manage from kitchen to the type of house you are living in. It gets different when you are living in a place where you are making a new house as you can manage everything from a totally new way. You can also make several types of amendment of many rooms of the house. Like this, you can have various ways of making a tropical living room. You do not need to spend millions to do this. Making a New Home Matching Tropical Climate It just needs some tint of perseverance as well as courage to get into a new ways of living. First thing you should do before planning other things is that you should get a land. May be you would like to live in some spare land in midst of forest. May be you would like to live somewhere in the midst of country people. May be you would like to live somewhere where there are hills and waterfalls? You should first decide these things. After this, you can jump to other plans. Like this, you may also want to get a garden and the plants that live in the same climate. You can go for it! Maintenance of Garden for Tropical Climate As per the garden outside your house, you can manage different things. You can choose the plants that give various types of fruits that grow in various seasons. You should at least try to get the type of plants and the flowers so that your garden does not seem totally dull in some season. Let your garden design ideas show all the joy and the status of the nature as per the season it has got for tropical living room. You should also make the necessary types of the caring in time to time. Putting water to the roots and also using manure as necessary. You can also study about different plants of tropical climate. Normally, garden boxes can be used for the use of various types of plants there in the house. Then, you should also take care of the design. When you have a full garden design ideas but every plant and the flower is in every place without proper way to walk with, your garden design ideas looks all mess in spite of all the things you have managed with labor. After this, you should also make the kitchen managed as a part of your living room? You should buy various storage shelves that reflect nature. In an ideal kitchen that shows tropical climate for tropical living room, it is necessary that you should put several of the food items such as they have grown there themselves in the room. You should get the shelves so that you can also differentiate the different places for the foods like dry foods. It is also necessary for other things like equipment storage. Different types of equipments like knives, spoons, these things help the kitchen to be better and an ideal one fortropical themed living room Several Types of Kids Storage Ideas Is your kids’ room a mess? Do you always plan something good and suggest to them but in spite of this, is there no change in your kids’ room? Do not worry; it is the condition of most families. All you need to be is a little bit patients and try to figure out things for your kids’ room needed. May be your kid is a real nerd who is always fond of books and these are only problems for all the mess of your kids’ room. May be your kid is really distracted due to various things which does not allow time for him/her to manage the,things of the room. In these conditions, including your kids don’t obey!, you can plan forkids storage ideas so that there is always clean as well as proper sanitation there in your kids room. First of all, you should manage the shoes and slippers your kids use. You can get various shoes boxers so that your kids have a habit of putting off their shoes or slippers out there which will allow the mess of the room to be little less. Establishing this habit will surely make the kids advantageous in future too. Likewise, you can also make various types of shoes boxes and decorate them. Making the Shoe Boxes as Kids Storage Ideas First of all, you can use those shoe boxes for putting several of the materials too. There may be coins, marbles, puzzles, art blocks or small playing things that are acting as clutter in your kids’ room. You can put them in the shoe box you have just prepared. You should not mistake of putting the box as plain as it is. You should always entice the children with various colorful things so that your children get joyful and try to look the box every time they need. You can use several of the crayons and colors out there to make different types of arts there in the box. You can also write something interesting that fascinates the kids. After that, you can use various lockers for storing several things. The main advantage of having lockers is that your kids learn about the secrecy maintenance to be done there. Put the locker in a suitable place where there can be safety as well as it increases in the decoration of the room. You can also put different types of drawers in your kids’ room. You can suggest them for the things that need to be done. Normally, when there are lots of drawers in the room that makes the room hectic. Putting Various Types of Arts You need to make a routine as well as index type of thing so that they learn where to place the things. Similarly, other main thing that is to be done is that you should make your kids’ room really attractive. You can put various types of colorful arts, picturesque of landscapes as well as different photos of the anime that your children get fascinated with. With these things, you can have different kids storage ideas for kids’ room. You should also not forget to make it simple and plain so that your kids learn something from it. Making the House Ceiling Design Look Magnificent Do you want to increase the beauty of your room with several of the ideas? When it has come to the ceiling design there are several of the ways you can make your ceiling better. First you can choose variable colors. First, you can go with the virtual image in computer or in drafts. You can use various types of graphs to analyze different parts of your room. The crucial point is that it should be properly done. With these ways, you can also add different paintings or something that has poetry or some good art as for house ceiling design. Using of Famous House Ceiling Design for Decoration You could also make something if you have got the creative streak there. Embellishment is always better for such sorts for house ceiling design. You can also use famous designs that can provide great storage of the things of the room. The room contains surely various types of things. There may be small things that destroy the good imagery of the room itself. The small things can be used to put in the box so that it looks clean and good. You can also paint in the walls using various ideas. This is because it also affects for the ceiling’s designs too. You can use various types of shading and lighting as per the room’s lighting and shading. Then you also should check over the proper lighting. Color the walls if necessary. You should also use the proper curtains, colors and direction of the things of your room to make a proper effect to be seen in ceiling. Try to use colors that last long that are durable. It is not required that you should use the popular companies’ colors. First requirement is that you should choose one that is durable. Management of Other Parts of the Room After that, you can come to some decorative choices. This also should be done if your budget allows for it. After this, you should go for the design. Design is highly important in the decoration of ceiling as it is the thing that really defines it. It is the main thing that people’s eyes go to when they enter the room. It is probably the biggest furniture that is used in the room. Every small thing should be given a stylish touch. You also should buy other things to make the ceiling look better. Suppose you are designing for the elitist room with few elitist things. When you are thinking of buying various things for the room, you should not just get into the supermarkets aiming for expensive things. You should know you should spend the money wisely. You should choose required things and manage them as beautifully as you can as. This is the main reason. You should not blunder of going to expensive type of stores. Do you know you could also buy secondhand things for this purpose? You may be puzzled. But, there are several of the cases where students have maintained the decoration sophisticated as well as intimidating with some secondhand thrift too. You can also get online help from various designers. Therefore, in these ways, you can get interior design photos and make your room look better.
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Hi all, if possible I'd like to work on three topic this year. (a) the cross-compilation for modular xorg (_except_ the server) (b) the refinement and integration of the new bulk build code (c) providing an interface for bulk build data from "official" builds similiar to pgksrc.se and pointyhat. Let me go somewhat in detail and I'm interested to hear your feedback. For a) This is an item from the main project list. Being able to compile modular Xorg from pkgsrc will basically allow us to get rid of xsrc, reducing maintaince and improving hardware support on many newer architectures. The Xorg server is not included for now, because it is one of the pieces which include a lot of platform specific magic and is therefore a lot more special. This is not such a big problem from the NetBSD perspective as many of the slower platforms have more special needs in that area anyway. From the pkgsrc perspective, I need to clean up the tool dependencies and verify the correctness of possible buildlink dependencies. The goal would be to make all native programs needed for cross-compilation use the tool framework and not depend on b3.mk. A side dependency for this is the DESTDIR support, but I have the missing pieces for proper working support mostly done in pre-commit state. The Xorg packages I've commited myself already support this anyway as should most, if not all of the dependencies. For b) This is also a long running item from the project list. The short answer is that the code is working and in active use for the DragonFly bulk builds. There's at least one other developer using it as well. The system needs quite a bit of hand-holding right now and doesn't support some of the features of the old infrastructure (e.g. limited bulk builds). The code is flexible enough that it should be possible to handle that, but I want to extend it in some areas anyway. Wish list items are welcome. The project would of course be to get it ready for full inclusion and as replacement of mk/bulk in all cases. For c) This is an area which interests me most. I want to establish something similiar to FreeBSD's automatic build system (http://pointyhat.freebsd.org) with the focus on the following items: (1) Which package is broken on which platforms? (2) How did that change over time? (3) Do I (as maintainer) want to be informed about changes automatically or not? This is meant to reduce the workload for wizd, but with some computation power in the backend this will help every user of pkgsrc. With the help of (b), it is possible for me to do a full (!) bulk build in around 4 days for DragonFly, at least the other AMD64 and IA32 systems should be similiar. That helps to catch a lot of common regressions fast, but catching them and fixing them is not the same. For the latter, you have to be know about the breakage :-) Joerg
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For Mari­ah Park­er, recent­ly elect­ed coun­ty com­mis­sion­er in Athens, Ga., being sworn into office on The Auto­bi­og­ra­phy of Mal­colm X was sim­ply a way of accu­rate­ly sig­nal­ing her world­view. It’s a view that’s ground­ed in a spe­cif­ic vision of what the world could be — one in which peo­ple of col­or, and black peo­ple in par­tic­u­lar, live free from the grip of racism and eco­nom­ic mis­ery. Of all the vol­umes in the rich tra­di­tion of Black Amer­i­cans’ quest for such a world, few are as deeply cher­ished as Malcolm’s tow­er­ing 20th-cen­tu­ry autobiography. Parker sees in black Americans’ story a struggle against oppression that is both uniquely their own and one patch in a larger quilt, one made up of tightly knit struggles on behalf of any community that has come under systemic fire. It’s a vision that’s increas­ing­ly gain­ing steam. Pro­gres­sive and social­ist can­di­dates of col­or, par­tic­u­lar­ly women with the wind of pop­u­lar move­ments at their backs, like New York’s Alexan­dria Oca­sio-Cortez, Michigan’s Rashi­da Tlaib and Minnesota’s Ilhan Omar, are run­ning on pre­cise­ly these sorts of plat­forms. And they’re winning. Pho­tos of Parker’s swear­ing-in quick­ly went gang­busters. In wide­ly cir­cu­lat­ed images, Parker’s afro is piled high and heav­en-bound (to bor­row a phrase from poet Hanif Abdur­raqib), and her right hand clenched in a fist rec­og­nized the world over as a sign of one’s com­mit­ment to stand along­side the oppressed. Her left hand rests atop the auto­bi­og­ra­phy, a book wide­ly cir­cu­lat­ed through­out black Amer­i­can com­mu­ni­ties, and one of the harsh­est indict­ments of the country’s long war against them. Though she had no idea this small act of sym­bol­ism would take the inter­net by storm, it’s hard­ly sur­pris­ing that it did. Park­er is smack-dab in the mid­dle of two of the Demo­c­ra­t­ic Party’s biggest crises. First, there’s the widen­ing gap between the pri­or­i­ties of the Demo­c­ra­t­ic Par­ty high­er-ups and its pop­u­lar base. Sec­ond, there are the Demo­c­ra­t­ic Party’s awk­ward strug­gles to deliv­er a con­vinc­ing mes­sage for address­ing the knot­ty rela­tion­ship between racial and eco­nom­ic oppres­sion. The view held from the com­mand­ing heights and man­age­r­i­al suites of the par­ty seems to be that, at best, race and class issues must be addressed sep­a­rate­ly, and at worst, that the two are at flat-out war with one anoth­er. Yet the avail­able evi­dence sug­gests black peo­ple feel dif­fer­ent­ly. It’s right there in years of sur­vey data, which con­sis­tent­ly finds black Amer­i­cans deeply con­cerned by both eco­nom­ic issues and the pow­er­ful role racism plays in suf­fo­cat­ing their chances at a bet­ter life. Unsur­pris­ing­ly, black vot­ers rank among the most eco­nom­i­cal­ly pro­gres­sive in the coun­try. It’s also been front and cen­ter in the clear-eyed pol­i­cy plat­forms of orga­ni­za­tions like BYP100 and the Move­ment for Black Lives. And it was there in Mari­ah Parker’s cam­paign for coun­ty commissioner. From Fer­gu­son to Bal­ti­more, and Philadel­phia to Chica­go, a fresh crop of black move­ment builders have issued a clear demand: the eman­ci­pa­tion of black peo­ple from the inter­wo­ven harms of racism and pover­ty. Groups like the Move­ment for Black Lives and the Black Youth Project have called for repa­ra­tions on the grounds that this com­bi­na­tion has made it eas­i­er to exploit and oppress black communities. After first tak­ing root in the streets, this gen­er­a­tions-span­ning strug­gle for racial and eco­nom­ic jus­tice is start­ing to sweep across cam­paigns for pub­lic office, Parker’s included. “Racial and eco­nom­ic injus­tice have been very inter­twined his­tor­i­cal­ly,” Park­er says. ​“There’s overt forms of vio­lence, like lynch­ing and police bru­tal­i­ty, but then there’s qui­et forms that are less easy to put your fin­ger on, like the inabil­i­ty to obtain cap­i­tal to open a busi­ness or own a home or the inabil­i­ty to union­ize.” Here, Park­er is drilling to the core of the black Amer­i­can expe­ri­ence, where both racism and eco­nom­ic exploita­tion have com­bined to increase the mis­ery index in black com­mu­ni­ties, in ways often sub­merged and thus hard­er to detect. ​“Tack­ling those things at once is so impor­tant because they are the hard­est things to see from the pub­lic per­spec­tive,” she says. The fact that Park­er, along with oth­er left-wing can­di­dates of col­or, such as Oca­sio-Cortez, find them­selves at this inter­sec­tion is sig­nif­i­cant. We rarely hear the voic­es of those most intense­ly impact­ed by pol­i­cy deci­sion. Women of col­or, giv­en their very notice­able near-total absence from estab­lished media, are the least seen and heard of all. Park­er, who co-found­ed Athens’ chap­ter of the pro­gres­sive Bernie Sanders-aligned Our Rev­o­lu­tion, is a 26-year-old rap­per, PhD stu­dent and open­ly queer black woman. She ran on a pro­gres­sive plat­form that put racial and eco­nom­ic jus­tice cen­ter stage, and won by a razor-thin mar­gin of 13 votes. Athens itself is a most­ly work­ing-class com­mu­ni­ty with a medi­an income that bare­ly ris­es above half the state of Georgia’s. This is even truer for Parker’s dis­trict, which the Atlanta Jour­nal-Con­sti­tu­tion describes as ​“an eco­nom­i­cal­ly strug­gling swath … that lacks some of the same ameni­ties that oth­er parts of town enjoyed.” On top of the district’s eco­nom­ic woes, it’s also ​“the most heav­i­ly pop­u­lat­ed black dis­trict in Athens,” Park­er tells In These Times. She goes on to argue that in a strug­gling com­mu­ni­ty with a high con­cen­tra­tion of black res­i­dents, peo­ple don’t view racism and pover­ty as dis­tinct evils with no con­nec­tion, but rather as twin giants that need to be knocked down simul­ta­ne­ous­ly. In speak­ing with Park­er, it’s clear that many of her wak­ing hours are spent con­tem­plat­ing the two, and that she sees a set of prin­ci­ples in Malcolm’s life and words that might help light the way to a bet­ter world. Park­er says that as an office­hold­er, she hopes to chan­nel Malcolm’s ​“capac­i­ty for being an out­spo­ken agi­ta­tor that pushed the con­ver­sa­tion in a rad­i­cal direc­tion.” Beyond his ser­mons of col­lec­tive black uplift and broad­er social change, Park­er is espe­cial­ly inspired by the fact that ​“in his lat­er life, he was will­ing to incor­po­rate new expe­ri­ences as a means of see­ing where the move­ment need­ed to go in order for the work to get done.” By this, Park­er is point­ing toward Malcolm’s per­son­al evo­lu­tion as a crit­ic of Amer­i­can pow­er. In his ear­li­est days, Mal­colm was a fierce but ide­o­log­i­cal­ly straight­jack­et­ed mouth­piece for the Nation of Islam. That all start­ed to change fol­low­ing his stormy split with the orga­ni­za­tion. In the months after, which now seem to have always been rac­ing toward his even­tu­al mur­der, Mal­colm became increas­ing­ly drawn to the moral force of social­ism and expressed a deep­en­ing belief in mul­ti­cul­tur­al, work­ing-class orga­niz­ing as the best weapon for con­fronting Amer­i­can pow­er. In a May 1964 Q&A host­ed by the Mil­i­tant Labor Forum, he went so far as to say, ​“It is impos­si­ble for a white per­son to believe in cap­i­tal­ism and not believe in racism. You can’t have cap­i­tal­ism with­out racism.” And toward the end of his life, he explained that ​“cap­i­tal­ism needs some blood to suck…and it can only suck the blood of the help­less.” The most help­less in Amer­i­ca would always be the com­mu­ni­ties most men­aced by those with pow­er and cheat­ed out of their fair share of it. That con­di­tion has defined the black Amer­i­can experience. Whether he knew it or not, Mal­colm was chan­nel­ing an idea with deep roots in black polit­i­cal life. From small-scale plan­ta­tion sab­o­tage under slav­ery to social­ist orga­niz­ing among share­crop­pers for work­place democ­ra­cy in the post-eman­ci­pa­tion south, his­to­ry offers a rich tapes­try of black resis­tance to a world where, as Dr. King once wrote, ​“the insep­a­ra­ble twin of racial injus­tice was eco­nom­ic injus­tice.” A half-cen­tu­ry after Malcolm’s assas­si­na­tion, the fight for that bet­ter world is still on. And the path­way to it, Park­er believes, runs through every­day peo­ple rec­og­niz­ing how America’s chart-top­ping inequal­i­ty, accord­ing to the World Eco­nom­ic Forum, hurts every­one but an elite few. ​“If we band togeth­er to fight against it,” Park­er says, ​“it is to everybody’s benefit.” Park­er sees in black Amer­i­cans’ sto­ry a strug­gle against oppres­sion that is both unique­ly their own and one patch in a larg­er quilt, one made up of tight­ly knit strug­gles on behalf of any com­mu­ni­ty that has come under sys­temic fire. It’s here that Malcolm’s abil­i­ty to trans­form, his abil­i­ty to stretch his imag­i­na­tion of what’s polit­i­cal­ly pos­si­ble when those who have been cast aside band togeth­er, echoes loud­est. ​“I do believe that cap­i­tal­ism relies upon social strat­i­fi­ca­tion. Be it in terms of abil­i­ty or gen­der or sex­u­al ori­en­ta­tion or immi­gra­tion sta­tus, it def­i­nite­ly relies upon oppres­sion of a kind,” Park­er adds. ​“In Amer­i­ca, that has fall­en par­tic­u­lar­ly along racial lines” but it’s impor­tant ​“to build sol­i­dar­i­ty across dif­fer­ent iden­ti­ty groups” to under­stand that ​“the sys­tem hurts everybody.”
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Should the criteria for species distinction in adenoviruses be reconsidered? Evidence from canine adenoviruses 1 and 2. Four strains of canine adenovirus type 1 (CAV-1) and two strains of canine adenovirus type 2 (CAV-2) were examined by restriction enzyme analysis. In all cases, CAV-1 could be readily differentiated from CAV-2. Additionally, monoclonal antibodies were prepared against the Mirandola and Manhattan strains of CAV-1 and CAV-2, respectively. 18 of 36 monoclonal antibodies from the CAV-1 fusion and 77 of 160 monoclonal antibodies from the CAV-2 fusion were type-specific by an indirect fluorescent-antibody technique. Moreover, among those type-specific monoclonal antibodies, 13 of the 18 CAV-1 antibodies and 39 of the 77 CAV-2 antibodies specifically neutralized only the homologous virus in vitro. These data, along with other evidence from the literature, suggest that not only should CAV-1 and CAV-2 be recognized as distinct species in the genus mastadenovirus of the family Adenoviridae, but also that the major criterion of species distinction in that family, namely neutralization, should be reconsidered.
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Q: C# Delaying without sleep public void delay() { var t = async delegate { await Task.Delay(15000)}; t.Wait(); } private void btnStart_Click(object sender, EventArgs e) { disable(); txtUrl.Text = "Link1"; webBrowser1.Navigate("Link1"); delay(); txtUrl.Text = "Link2"; webBrowser1.Navigate("Link2"); delay(); txtUrl.Text = "Link3"; webBrowser1.Navigate("Link3"); I'm trying to make an app that surfs three links automatically every 15 seconds, but this does not work. This kind of delay functions cause sleep when I run it. A: You should use async await keyword like this public Task delay() { return Task.Delay(15000); } private async void btnStart_Click(object sender, EventArgs e) { disable(); txtUrl.Text = "Link1"; webBrowser1.Navigate("Link1"); await delay(); txtUrl.Text = "Link2"; webBrowser1.Navigate("Link2"); await delay(); txtUrl.Text = "Link3"; webBrowser1.Navigate("Link3"); // ... }
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gcr.io/google_containers/kube-scheduler-ppc64le:v1.10.0-beta.0
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Led by Professor Alfonso Jaramillo in the School of Life Sciences, new research has discovered that a common molecule -- ribonucleic acid (RNA), which is produced abundantly by humans, plants and animals -- can be genetically engineered to allow scientists to program the actions of a cell. As well as fighting disease and injury in humans, scientists could harness this technique to control plant cells and reverse environmental and agricultural issues, making plants more resilient to disease and pests. RNAs carry information between protein and DNA in cells, and Professor Jaramillo has proved that these molecules can be produced and organised into tailor-made sequences of commands -- similar to codes for computer software -- which feed specific instructions into cells, programming them to do what we want. Much like a classic Turing computer system, cells have the capacity to process and respond to instructions and codes inputted into their main system, argues Professor Jaramillo. Similar to software running on a computer, or apps on a mobile device, many different RNA sequences could be created to empower cells with a 'Virtual Machine', able to interpret a universal RNA language, and to perform specific actions to address different diseases or problems. This will allow a novel type of personalised and efficient healthcare, allowing us to 'download' a sequence of actions into cells, instructing them to execute complex decisions encoded in the RNA. The researchers made their invention by first modelling all possible RNA sequence interactions on a computer, and then constructing the DNA encoding the optimal RNA designs, to be validated on bacteria cells in the laboratory. After inducing the bacterial cells to produce the genetically engineered RNA sequences, the researchers observed that they had altered the gene expression of the cells according to the RNA program -- demonstrating that cells can be programmed with pre-defined RNA commands, in the manner of a computer's microprocessor. Professor Alfonso Jaramillo, who is part of the Warwick Integrative Synthetic Biology Centre, commented: "The capabilities of RNA molecules to interact in a predictable manner, and with alternative conformations, has allowed us to engineer networks of molecular switches that could be made to process arbitrary orders encoded in RNA. "Throughout the last year, my group has been developing methodologies to enable RNA sensing the environment, perform arithmetic computations and control gene expression without relying on proteins, which makes the system universal across all living kingdoms. "The cells could read the RNA 'software' to perform the encoded tasks, which could make the cells detect abnormal states, infections, or trigger developmental programs."
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Cook – Weekly Apprenticeship Training System (WATS) Develop a recipe for success Breadcrumb Contact us If you have an interest in preparing food, possess a keen sense of taste and smell, and are creatively-inclined, you have all the ingredients for a Red Seal designation – combine them in the Cook Apprenticeship. With the right combination of ingredients, training and skill, you can create magic in the kitchen. And your recipe for success can be found in the Cook – Weekly Apprenticeship Training System (WATS) program. From catering special banquets to preparing meals for large institutions to cooking up gourmet delights in an upscale restaurant, your Cook Apprenticeship prepares you for it all. This three-year apprenticeship takes place with your needs in mind. One day a week is spent here at the college, expanding your expertise and gaining technical training vital to your culinary future. For the rest of the week, you’ll be putting what you’ve learned into practice on the job. It’s the perfect blend that allows you to pursue your education while continuing to earn an income. Prepare for your Red Seal exam and apply to the Cook Apprenticeship program today! Career opportunities In just three short years, you’ll be ready to write the Red Seal exam and pursue your career in: restaurants clubs institutions hotels bases and camps At-a-Glance Starts In: August Duration: 3 years Credential: Certified 'Journeyman' Papers Courses Delivery Format Classroom Learning Environment Weekly Apprenticeship Training System (WATS) programs involve one day of training at Lethbridge College per week throughout the length of the program. The perfect blend Spend just one day a week on campus gaining technical training vital to your career. Many apprenticeships require you to be on campus and away from the job for periods of eight weeks at a time. But with the Weekly Apprenticeship Training System, you remain employed on a full-time basis. Just one day a week is spent here on campus gaining technical training vital to your career. It’s what we call the perfect blend. Hands-on, immersive training Students serving students Students serving students Unlike most culinary programs where, for cost-saving purposes, students learn by watching demos and are then expected to somehow survive in the industry, at Lethbridge College you’ll actually prepare food. In fact, you’ll be treated like an employee as you prepare all food on campus from scratch. That food is then used in upcoming menus for our Food Court and Garden Court dining room as well as banquets and special functions. Our Culinary Services experience truly is students serving students. With the exception of a required amount of theory (based on hours) in a traditional classroom, you’ll spend the majority of your time learning in kitchens and labs that emulate the restaurants, clubs and large scale operations like cruise ships and oil camps that will one day be your workplace. Culinary…sciences? Culinary…sciences? Though often referred to as the culinary arts, there is a whole other side to cooking: science. And in our culinary arts programs, we’re bringing that science into the classroom to improve your skills and expertise. Intrigued? You’ll have the opportunity to participate in ongoing organoleptic (sensory) testing led by Chef Rob Sonnenberg. It’s a test you can’t exactly prepare for. You’ll taste a variety of produce that could be from the aquaponics facilities a hundred metres away or from a store that’s a kilometer down the street. And your insights into things like preference, taste, look, smell and texture will help determine just how good the produce grown in our aquaponics facilities is. Skills Canada Skills Canada After a year or two here, you’ll have what it takes to compete with the best of the best in your field on the provincial and national stage at Skills Canada. The Skills Canada National Competition is the only national, multi-trade and technology competition for students and apprentices in the country. It’s an experience of lifetime, with the possibility of being named the nation’s best in your chosen field. That opportunity starts with the exceptional hands-on training you’ll receive at Lethbridge College. Red Seal designation The ultimate goal of your apprenticeship is to work towards obtaining a journeyman and Red Seal in Cooking at the end of three years. The Red Seal is the Canadian standard for excellence in skilled trades and is respected nationally and globally, opening up doors for your career. Our students can be found cooking in kitchens all over the world, competing in the World Culinary Olympics (and winning gold), supporting Culinary Team Alberta and Canada on the international stage, and opening up their own restaurants and establishments. Upon successful completion of your apprenticeships and exams, you’ll receive a Red Seal endorsement on your provincial trade certification. And with that designation, you’ll be able to go from here to wherever your career takes you. A taste of what's to come Around the world without leaving campus Our award-winning chefs will take you on a culinary expedition. A 100-metre meal? It’s possible with fresh ingredients from our Aquaculture Centre. A blast (of flavour) from the past It was part of the curriculum back in the '60s and it's still on the menu today. What’s for dessert? Pistachio and coconut lime gelato! From here to there: alumni updates Lethbridge College isn’t just a place to go to school – we’re a community that is here to support you from your initial interest in our program through to the moment you cross the stage at Convocation and beyond. Just take a look at where an LC education has taken some of our grads. Jennifer Cearns The Alberta Apprenticeship and Industry Training Board named Jennifer Cearns the 2016 Top Cooks Apprentice. “In addition to working full-time and taking care of her young family, Jennifer was a student in the Weekly Apprentice Training for Cooks program at the college,” says her instructor, Chef Rob Sonnenberg. “Jennifer was extremely hard-working. She would come to the college two hours before her class started to study (often encouraging others in the course to join her). She was driven to understand the science behind cooking and always wanted to know all the answers.” Cearns works for the Good Samaritans Society at Linden View in Taber. Debbie Johnson After graduation, Debbie worked in restaurants for a few years and then went to McGill University where she earned a B.Ed. degree. She has been teaching cooking for 22 years now and during that time, she earned a diploma in pastries and desserts and then went back to McGill where she received a Master’s degree in education. She says it’s “been a busy career, and loving it!”
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1. Technical Field Embodiments generally relate to media systems. More particularly, embodiments relate to power management of audio accelerators. 2. Discussion In conventional mobile computing platforms, audio accelerators may be used to reduce the computing load on a CPU (central processing unit) by conducting certain audio-specific functions such as decoding audio formats and post-processing audio streams. During periods of inactivity (e.g., in response to the user halting audio playback), a device driver running on the CPU may place the audio accelerator into a suspend mode in order to conserve power. The process of suspending the audio accelerator and resuming the audio accelerator to the active mode, however, may involve time intensive state restoration operations. In particular, these operations may be considered “heavyweight” in that they could lead to audio response latencies that are noticeable to the user and additional processing overhead that increases power consumption and reduces battery life.
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Orthodontic and bone grafting procedures in a cleft lip and palate series: an interim cephalometric evaluation. An attempt is being made to observe the facial and dental development of a cleft lip and palate sample. The study is continuing and, hopefully, offers insight into what happens to these children who have undergone the placement of a dentofacial maxillary orthopedic appliance early at the time of lip closure and an additional surgical procedure and autogenous osteoplasty. Though the final answers to the two previously posed questions are not yet available, we are able to make some value judgments by observing the lateral cephalometric films of these children, and observing their occusion intraorally. Thus far, we are able to state that in our sample, using our treatment procedures in the sequence advocated, we have seen no growth attenuation in the posterior/anterior dimension. The maxilla, at least to the ages observed, does not appear to have been attenuated by our procedures. Further, it would seem that after a limited first phase of orthodontic treatment to align dental units, the degree of crossbite is considerably smaller from that reported in the literature by those using more conventional approaches; thus it is possible that we are doing some good. We are still using these procedures on our newborn and continue to feel that we have a real opportunity to be able to do more orthodontically for these children when they possess a full, permanent dentition and are ready for comprehensive treatment.
{ "pile_set_name": "PubMed Abstracts" }
Q: How to resolve the below given JS error? Here is what I am trying to accomplish: A new variable called theRightSide is created. This points to the right side div e.g. var theRightSide = document.getElementById("rightSide"); After all the images have been created and added to the leftSide div, use cloneNode(true) to copy the leftSide div e.g. leftSideImages = theLeftSide.cloneNode(true); Then, delete the last child of leftSideImages Then, add leftSideImages to the rightSide div Here 's my code: <html> <head> <style type="text/css"> img { position:absolute; } div { position:absolute; width:500px; height:500px; } #rightSide { left: 500px; border-left: 1px solid black; } </style> </head> <body onload="generateFaces()"> <h1>Matching Game</h1> <div id="leftSide"></div> <div id="rightSide"></div> <script> var numberOfFaces=5; var theLeftSide = document.getElementById("leftSide"); function generateFaces(){ for (var i = 0; i < numberOfFaces; i++) { var img = document.createElement("IMG"); img.src="smile.png"; img.style.top=Math.floor(Math.random()*401); img.style.height=100; img.style.left=Math.floor(Math.random()*401); theLeftSide.appendChild(img); }; } leftSideImages = theLeftSide.cloneNode(true); var theRightSide = document.getElementById("rightSide"); leftSideImages.removeChild(leftSideImages.lastChild); theRightSide.appendChild(leftSideImages); </script> </body> </html> Error: Uncaught TypeError: Failed to execute 'removeChild' on 'Node': parameter 1 is not of type 'Node'. Please help me resolve this two errors. A: It seems to suggest that var theLeftSide = document.getElementById("leftSide"); is returning null. Are you are that element exists and has that id? Fiddle: http://jsfiddle.net/yuhc6rdm/
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<action-sequence> <name>template1.xaction</name> <version>1</version> <title>Test of template component</title> <logging-level>debug</logging-level> <documentation> <author>James Dixon</author> <description></description> <help></help> </documentation> <inputs> <customer type="string"> <default-value>None</default-value> <sources> <request>customer</request> </sources> </customer> <region type="string"> <default-value>West</default-value> </region> <template type="string"> <default-value>Customer '{customer}' is in region {region}</default-value> </template> </inputs> <outputs> <output type="string"/> </outputs> <resources/> <actions> <action-definition> <action-inputs> <customer type="string"/> <region type="string"/> <template type="string"/> </action-inputs> <action-outputs> <output type="string"/> </action-outputs> <component-name>TemplateComponent</component-name> <action-type>rule</action-type> <component-definition> </component-definition> </action-definition> </actions> </action-sequence>
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Moonscoop Scores Four With MBC3 PARIS, 15 September 2010. Moonscoop, one of the leading worldwide distribution, brand management and entertainment companies, has expanded the presence of its animated shows in the Middle East by scoring a package deal with MBC3. The free tv channel has snapped up four new shows from Moonscoop’s distribution slate: Zevo-3 (26x30’), Gasp! (52x11’), The DaVincibles (52x11’) and Tara Duncan (26x30’). Marie Conge, Senior Vice President International Sales and CPG at Moonscoop said: “It’s fantastic to get such a strong response from a broadcaster to new programming. What makes these shows standout in the crowded animation market is the high mix of comedy and adventure, and also that they appeal equally to both boys and girls.” Zevo-3 is a new animated action/comedy series featuring three teens who develop super powers after being accidentally exposed to the Zevo compound, a dangerous genetic enhancer. Moonscoop is producing the show for Skechers Entertainment, and is also handling worldwide distribution. GASP is a “fin-slapping” funny animated comedy series based on the highly acclaimed comic book series by Australian author and illustrator Terry Denton. Told from the point of view of a friendly, lovable goldfish named Gasp, the series explores family relationships through the wacky adventures of pets left home alone. Gasp lives in a world where animals walk, talk and watch TV, guppies ride motorbikes, and goldfish surf the internet...that is when the humans aren't around. The series is produced by SLR Productions, in association with Screen Australia, Network Nine Australia, ABC Kids, Agogo and Moonscoop and targets kids 6-11 years. The DaVincibles (52x11) is a classic cartoon comedy adventure caper for 7-11 year olds which is co-created and co-produced by Moonscoop and Neo Network. Rai Fiction, SLR, Telegael and Big Animation are also on board as co-production partners, and broadcast deals have been signed with France’s Gulli and Seven in Australia. The series follows the comedic exploits of the modern-day DaVinci family, with Pablo and Zoe and friends balancing their day to day school assignments, social lives, and peer pressures, as they explore the world for rare artifacts to sell at Uncle Leo’s Kurios Kat antique shop. The series is filled with kid-relatable stories with over-the-top funny characters on madcap adventures to save the world, which lead them from the Arctic Circle to the Amazon Jungle to the pyramids of Egypt. Tara Duncan (26x22’) is new 2D animation for 8-12 year olds co-produced by Moonscoop and DQ Entertainment (DQE) with France’s M6 and Disney Channel France on board as broadcast partners. Moonscoop has worldwide distribution and licensing rights, with the exception of Asia which are handled by DQE. Moonscoop has already signed a raft of merchandising deals in stationery, back to school, charms and headwear categories. The animated show is based on the best-selling set of seven children’s fantasy books by Sophie Audouin-Mamikonian, which is already a publishing hit in France, Italy, Spain Portugal, Germany, Japan, Korea, Thailand, Romania and Bulgaria. Combining all the best elements of magic, comedy and action, the series follows the story of a beautiful teenage girl bestowed with magical powers who finds herself in a high stakes battle against evil forces from another world. Each episode starts with Tara finding herself in a quirky situation with the promise of a challenging adventure ahead. About MoonscoopMoonscoop is a leading worldwide kids production, distribution, brand management and entertainment company, focused on producing original projects and building brands with international appeal and longevity. Its rights library combines many of the most successful programs and best-loved animated creations in the global television market and includes over 3,000 half-hours of programming airing in more than 160 territories worldwide. Key brands include "Code Lyoko," "Fantastic Four," "Titeuf" (Tootuff), “Chloe’s Closet.” “Hero:108”, “Dive Olly Dive!” “Geronimo Stilton” and "Casper" which are licensed in markets around the world. Moonscoop’s production slate currently includes “Hero:108 2”, "Tara Duncan", “Geronimo Stilton season2”, “Casper season2”, "The Davincibles" and "Super Sportlets" and feature film of "Titeuf".
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Recrystallization from ether causes unusual changes in the convulsant activity of pentylenetetrazol. The convulsant activity of commercial pentylenetetrazol (PTZ) and that of pentylenetetrazol recrystallized from ether (PTZE) were compared in the waking rabbit by means of recording the electrical activity of the brain. In addition, the interaction between the two substances was studied. When given in slow intravenous infusion, PTZE proved only half as effective as PTZ (threshold doses: 23.18 +/- 1.8 mg/kg and 12.40 +/- 0.7 mg/kg, respectively). One single infusion of PTZE 5-10 days prior to the administration of PTZ decreased the latter's convulsant activity to half of the original, while PTZ pretreatment left the activity of PTZE unaltered. Previous physico-chemical investigations suggested that, after recrystallization from ether the molecule might be present in dimer form at the phase-boundaries. Such a process, if taking place also at the cell membrane surface might account for the diminished convulsant activity of the recrystallized molecule.
{ "pile_set_name": "PubMed Abstracts" }
WITH its stout brick houses and wrought-iron balconies, as well as occasional tower blocks, Molenbeek would not be out of place in a multicultural corner of any western European capital. Residents can shop at the Marrakech baker, Islamic butcher, Halal Turkish Pizzas or the King of Saree. A rundown Islamic centre offers classes in rapid memorisation of the Koran around the corner from a main commercial street strung with municipal Christmas lights. In recent days, after the carnage in Paris, Molenbeek has changed in the public imagination from an edgy ethnic corner of Brussels into a nest of European jihadism. One of the Paris suicide-bombers, Brahim Abdeslam, was a French citizen who lived in the area. His younger brother, Salah, is believed to have fled back to Belgium after the carnage. Raids by armed Belgian police in Molenbeek on November 16th and 19th were intended to track him down. The presumed mastermind of the attacks, Abdelhamid Abaaoud, a Belgian of Moroccan descent, also grew up in Molenbeek. He had been assumed to be in Syria—Islamic State’s glossy magazine even “interviewed” him about his exploits in evading capture. But on November 18th French police fought their way into a flat in Paris where he was thought to be hiding. A woman blew herself up; Mr Abaaoud died, too. The public prosecutor said the raid had foiled another imminent plot to attack the Paris region. Molenbeek has a longer association with jihadism. Former residents of north African extraction include the killers of Ahmad Shah Massoud, the commander of Afghanistan’s anti-Taliban Northern Alliance, who was assassinated in 2001 as a prelude to al-Qaeda’s attacks on America on September 11th; a man involved in the Madrid train bombings in 2004; a man who killed four people at a Jewish museum in Brussels in 2014; and a man who tried to kill passengers on a high-speed train from Amsterdam to Paris in August. As Charles Michel, the Belgian prime minister, puts it, “Almost every time [there is an attack], there’s a link with Molenbeek.” The question of why some of Europe’s young Muslims become radicalised, fight in Syria and kill their own fellow-citizens is a conundrum that worries all governments—none more so than Belgium’s. France has more Muslim citizens than any other country in the European Union, and the largest number of foreign fighters in Syria; but Belgium has the highest proportion of those fighters as a share of its population (see chart 2). The causes are not only, and perhaps not mainly, Islamic puritanism and economic marginalisation—although Molenbeek, where locals complain of unemployment and discrimination, has its share of both. In June a French parliamentary report pointed to more personal factors: “an existential quest” for identity and belonging undertaken by those with “psychological and social malaise”. Those heading for Syria are often petty criminals. But there are also middle-class youngsters, young girls and converts, says Dounia Bouzar, who runs a French deradicalisation centre. Despite this variety, the fact that many of the attacks in Europe in recent years have been carried out by people tagged by security agencies as potential extremists suggests the spooks are at least looking in the right pool of suspects. But the numbers are so large that it is impossible even for the most generously funded agencies to monitor them all. It apparently takes from 20 to 60 people to follow a single suspect around the clock. Whether or not Belgium has a worse problem with radicalism than elsewhere, it is clearly struggling to cope with it. Its police and intelligence forces are, like most of the country’s institutions, fragmented and under-resourced. It has long had a reputation as the way-station for drug- and gun-smuggling between the Netherlands and France. Another problem is that Belgium lies at the heart of the Schengen zone area. Once a gun is smuggled across the external border of the free-travel area, typically from the Balkans, where they are plentiful, it can be taken freely across much of Europe. Black-market prices suggest that automatic weapons are cheapest in the Balkans and most expensive in Britain, which is outside Schengen. Some reports say that weapons used in the Charlie Hebdo attacks in Paris in January came from a specialist in Slovakia. If the Schengen zone is border-free for holidaymakers and terrorists, it is full of unseen barriers for police and intelligence agencies. Authorities have no means of monitoring passenger-name records for cross-border travellers, even those coming from outside Schengen. Where passports are looked at, eg, at airports, the identities of Schengen-area citizens are not systematically checked against databases of suspected criminals or terrorists. Too many of the supposed joint European databases contain little data, or cannot be properly searched. Even when a suspect’s name records a hit, all that comes back is the name and number of a police officer to be contacted for information. Despite fears that jihadists could be slipping into Europe with the flood of refugees, European police forces cannot gain access to the Eurodac database that records fingerprints and other details of asylum-seekers. Some, especially on the far right, are clamouring for the abolition of Schengen. But even if European voters were to put up with border controls, it would be impossible to check the roughly 200 road crossings between Belgium and France alone. Mr Abdeslam is said to have slipped past several police checkpoints as he fled Paris.
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Baylor University said this week that a “miscommunication” between administration officials and tour guides led to the removal of a student newspaper that reported about an alleged rape on campus. Eyewitnesses said Baylor student tour guides removed issues of the Baylor Lariat earlier this month at certain places on campus. The Feb. 8 issue of the paper had a front-page story titled “Fifth alleged rape reported.” “Campus Visits has never given blanket instructions to campus tour guides to remove papers from newsstands or to shy away from answering any question honestly and factually from prospective students and their families about our campus today and past issues,” Jason Cook, Baylor’s vice president for marketing and communications, said in a statement to the Baylor Lariat on Thursday. “They were not asked to destroy or remove papers.” ADVERTISEMENT “We have learned there was a miscommunication at an event on Feb. 9, when an admissions staff member asked a few campus tour staff to move papers in the Penland Crossroads lobby and Foster,” Cook said. “Unfortunately, papers in the Penland lobby were thrown away while papers in Foster were moved within the newsstand or recycled.” Baylor did not immediately respond to a request for comment from The Hill. Students spoke to the student newspaper about the incident last month. “The girl who took the newspaper from our table, she told us her boss had told her to do it,” senior Ben Christie said. “Then they said it was something they didn’t want students to see.” “A female tour guide came up and grabbed my friend’s newspaper, I imagine to hide it from guests,” senior Hunter Meroney added. “After that, we saw her take the rest of the newspapers off the stands at Penland [Crossroads] and throw them away.” Feb. 9 was “Know Where You’re Going Day” at Baylor and reportedly saw an estimated 2,000 prospective students touring the campus.
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[Classification of surgical complications: analysis of the group of consecutive patients]. The aim of the work was to evaluate the implementation of Clavien - Dindo classification of surgical complications into a routine clinical praxis and to evaluate the results achieved at the university department of surgery. Prospectively collected data of patients hospitalized at the Clinic of Surgery of the University Hospital in Hradec Králové between January 2010 and September 2012 were retrospectively evaluated. Incidence, spectrum and severity of postoperative complications were evaluated according to individual surgical specializations. 9039 patients were operated and enrolled into the database during the time period from January 2010 to October 2012. A surgical complication was recorded in 1248 (12.9%) patiens, grade I. in 284 (3.4%) cases, grade II. in 384 (4.3%) cases, grade III in 370 (4.1%) cases, grade IV. in 67 (0.7%) patients. Death,i.e. grade V., occurred in 143 (1.43%) patients. Clavien - Dindo classification of surgical complications was successfully implemented into a routine clinical praxis at the department of surgery, University Hospital Hradec Králové. Wider use of this classification system would improve conditions for evaluation and comparison of results between different surgical approaches, surgeons or departments.
{ "pile_set_name": "PubMed Abstracts" }
IN THE SUPREME COURT OF PENNSYLVANIA WESTERN DISTRICT TELETRACKING TECHNOLOGIES, INC., : No. 355 WAL 2015 : Petitioner : : Petition for Allowance of Appeal from : the Order of the Superior Court v. : : : FRANK J. GORI, MARK JULIANO, GENE : NACEY, LORRAINE NACEY, STEPHEN : P. NASH, BRIAN E. SCHULIGER, : INSIGHT VENTURE MANAGEMENT, : L.L.C. AND INSIGHT TTT, LLC., : : Respondents : ORDER PER CURIAM AND NOW, this 22nd day of December, 2015, the Petition for Allowance of Appeal is DENIED.
{ "pile_set_name": "FreeLaw" }
Q: What is the difference between a property and a variable I have a confusion about understanding Property and Variables public class ABC() { public int A; public int B { get; set; } } What is the exact difference between in A and B? A: As many have pointed out, A is a field, B is a property. The real question is, why should you care, and what to use? I refer to a blog post of Jonathan Aneja: (Its in VB, but it applies to C# as well ;)) So why use properties over fields, 5 reasons: 1. Fields can’t be used in Interfaces You can’t enforce the existence of a field in an object’s public contract through an interface. For properties though it works fine. 2. Validation While your application currently may not require any validation logic to set a particular value, changing business requirements may require inserting this logic later. At that point changing a field to a property is a breaking change for consumers of your API. (For example if someone was inspecting your class via reflection). 3. Binary Serialization Changing a field to a property is a breaking change if you’re using binary serialization. Incidentally, this is one of the reasons VB10’s auto-implemented properties have a “bindable” backing field (i.e. you can express the name of the backing field in code) – that way, if you change an auto-implemented property to an expanded property, you can still maintain serialization compatibility by keeping the backing field name the same (in C# you’re forced to change it because it generates backing fields with unbindable names). 4. A lot of the .NET databinding infrastructure binds to properties but not fields I’ve heard arguments on both sides as to whether or not that’s a good thing, but the reality is that’s the way it works right now. (Note from me: WPF bindings work on properties) 5. Exposing a public field is an FxCop violation For many of the reasons listed above :) There might be more reasons. I would also like to point to a blog post of Jeff Atwood and conclude with a quote from it: The really important thing to take away here is to avoid writing code that doesn't matter. And property wrappers around public variables are the very essence of meaningless code. A: A is a field, B is a property. A property is basically syntactic sugar for getters and setters. The class you have defined will be compiled into something like this: public class ABC() { public int A; private int backing_B; public void set_B(int value) { backing_B = value; } public int get_B() { return backing_B; } } Note that this kind of conversion is true for all C# properties -- accesses to ABC.B will be converted to method calls. Properties basically provide the illusion of a "variable" while actually just being a cleverly disguised pair of methods. This is important, because it allows you to declare your own get and set method body, which can validate values or do other interesting things: private int b; public int B { get { return b; } set { if (value < 0) throw new ArgumentOutOfRangeException("value"); b = value; } } Note that most properties will use a field to store their value. Properties seldom exist on their own, apart from fields. A: A property is sort of a short getter and or setter. You can add logic to the set or get of the property or make them private which means that they are not accessible from the out side, where a variable is always accessible (if it is public).
{ "pile_set_name": "StackExchange" }
Kansas abortion-rights lobbyists Elise Higgins, left, and Holly Weatherford, watch the Senate's debate on anti-abortion legislation from the gallery on April 5. / John Hanna, AP by By John Hanna, Associated Press by By John Hanna, Associated Press TOPEKA, Kan. (AP) - Kansas legislators gave final passage to a sweeping anti-abortion measure Friday night, sending Gov. Sam Brownback a bill that declares life begins "at fertilization" while blocking tax breaks for abortion providers and banning abortions performed solely because of the baby's sex. The House voted 90-30 for a compromise version of the bill reconciling differences between the two chambers, only hours after the Senate approved it, 28-10. The Republican governor is a strong abortion opponent, and supporters of the measure expect him to sign it into law so that the new restrictions take effect July 1. In addition to the bans on tax breaks and sex-selection abortions, the bill prohibits abortion providers from being involved in public school sex education classes and spells out in more detail what information doctors must provide to patients seeking abortions. The measure's language that life begins "at fertilization" had some abortion-rights supporters worrying that it could be used to legally harass providers. Abortion opponents call it a statement of principle and not an outright ban on terminating pregnancies. "The human is a magnificent piece of work at all stages of development, wondrous in every regard, from the microscopic until full development," said Sen. Steve Fitzgerald, a Leavenworth Republican who supported the bill. Abortion opponents argue the full measure lessens the state's entanglement with terminating pregnancies, but abortion-rights advocates say it threatens access to abortion services. The declaration that life begins at fertilization is embodied in "personhood" measures in other states. Such measures are aimed at revising their constitutions to ban all abortions, and none have been enacted, though North Dakota voters will have one on the ballot in 2014. But Kansas lawmakers aren't trying to change the state constitution, and the measure notes that any rights suggested by the language are limited by decisions of the U.S. Supreme Court. It declared in its historic Roe v. Wade decision in 1973 that women have a right to obtain abortions in some circumstances, and has upheld that decision while allowing increasing restrictions by states. Thirteen states, including Missouri, have such language in their laws, according to the National Right to Life Committee. Sen. David Haley, a Kansas Democrat who opposed the bill, zeroed in on the statement, saying that supporters of the bill were pursuing a "Taliban-esque" course of letting religious views dictate policy limiting women's ability to make decisions about health care and whether they'll have children. And in the House, Rep. John Wilson, a Lawrence Democrat, complained that the bill was "about politics, not medicine." "It's the very definition of government intrusion in a woman's personal medical decisions," he said. Brownback has signed multiple anti-abortion measures into law, and the number of pregnancies terminated in the state has declined 11 percent since he took office in January 2011. The governor said he still has to review this year's bill thoroughly but added, "I am pro-life." This year's legislation is less restrictive than a new North Dakota law that bans abortions as early as the sixth week of pregnancy and a new Arkansas law prohibiting most abortions after the 12th week. But many abortion opponents still see it as a significant step. "There is a clear statement from Kansas with respect to the judgment on the inherent value of human life," said Senate Public Health and Welfare Committee Chairwoman Mary Pilcher-Cook, a Shawnee Republican and leading advocate for the measure. The bill passed despite any solid data on how many sex-selection abortions are performed in Kansas. A 2008 study by two Columbia University economists suggested the practice of aborting female fetuses - widespread in some nations where parents traditionally prefer sons - is done in the U.S. on a limited basis. But legislators on both sides of the issue said the practice should be banned, however frequent it is. The bill also would require physicians to give women information that addresses breast cancer as a potential risk of abortion. Advocates on both sides acknowledge there's medical evidence that carrying a fetus to term can lower a woman's risk for breast cancer, but doctors convened by the National Cancer Institute a decade ago concluded that abortion does not raise the risk for developing the disease. The provisions dealing with tax breaks are designed to prevent the state from subsidizing abortions, even indirectly. For example, health care providers don't have the pay the state sales tax on items they purchase, but the bill would deny that break to abortion providers. Also, a woman could not include abortion costs if she deducts medical expenses on her income taxes. "Every taxpayer will be able to know with certainty that their money is not being used for abortion," Pilcher-Cook said. But Jordan Goldberg, state advocacy counsel for the New York City-based Center for Reproductive Rights, called the tax provisions "appalling and discriminatory." "It's probably, if not definitely unconstitutional, and it's incredibly mean-spirited," she said. Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Send this page to someone via email A local grocer isn’t taking any chances with what he calls a ‘ridiculous’ upward trend when it comes to shoplifting. Food Fare’s Munther Zeid told 680 CJOB he’s not prepared to lose product the way Liquor Marts have over the past year, so his staff take a proactive approach to tackling crime. “We don’t approach a shoplifter unless it’s a minimum of two people approaching,” he said. “It’s no secret. We approach them armed. We have baseball bats, and all we want is our product back. Tweet This “When they see a sign of force, they’re actually handing over the product with no issues.” READ MORE: Private security companies see boom in industry because of shoplifting Story continues below advertisement Liquor Mart thefts have been an ongoing problem in Winnipeg. According to numbers from Manitoba Liquor and Lotteries, incidents of theft jumped from 658 thefts in Liquor Marts in 2017 to more than 2,600 last year. Five teens were arrested last week after what appeared to be an organized mob of suspects rushed into a Winnipeg liquor store, stealing hundreds of bottles of booze. Video of the brazen theft was later posted to social media. Winnipeg police spokesperson Const. Rob Carver said its getting more common to see criminals working in groups to steal items from retail stores, and it’s not just happening at liquor stores. Zeid said meat and cheese have become high-target items at his stores, with between 25-30 shoplifters being caught in a week – at a single location. He said he and his employees will continue to confront shoplifters caught in the act. “Some people get mouthy and try to leave, but at the same time, we’re there to protect ourselves, our store, and our customers.” WATCH: ‘It’s quadrupled;’ Food Fare owner says brazen thefts not limited to Manitoba Liquor Marts 1:29 ‘It’s quadrupled;’ Food Fare owner says brazen thefts not limited to Manitoba Liquor Marts ‘It’s quadrupled;’ Food Fare owner says brazen thefts not limited to Manitoba Liquor Marts
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A postprofessional distance-education program in neurodiagnostics and sleep science. Sleep medicine is a quickly growing field of allied health and preventive medicine. The University of North Carolina has proven innovative and timely in offering a neurodiagnostics and sleep science bachelor's degree program for the sleep medicine profession.
{ "pile_set_name": "PubMed Abstracts" }
Hard-line religious activists in Russia are really offended by Facebook's new same-sex marriage icons and want the social networking website banned from the country. Russian Orthodox activists in the southern city of Saratov claim the icons are "gay propaganda," and have told Facebook to stop "flirting with sodomites." The group sent Facebook a 24-hour ultimatum to the site's offices in Russia, which Facebook has reportedly ignored, according to news service RussiaToday. Undeterred, the activists have threatened to sue Internet service providers who provide access to Facebook. They've also begun a signature-signing campaign to reinstate a 1993 law that banned homosexuality. According to an Orthodox leader, the campaign has logged 34,000 signatures in three days. They hope to collect at least 1 million signatures and present the petition to the Russian parliament. Facebook "openly popularizes homosexuality among minors," according to orthodox activist Vladmiry Roslyakovsky, who is spearheading the campaign. He added that the movement has gained support from Muslim, Jewish and Catholic members. Roslyakovsky said the same-sex marriage icons could influence minors to turn gay because the United States's goal is for Russians to stop having children. He told a Saratov news organization that he is "confident that Russian laws and reasonable citizens will be able to protect their children from a fierce attack of sodomites." A pro-LGBT activist told Gay Star News that the activist's controversy-baiting comments is to "attract attention" because using gay topics in a negative light is a "very simple way to get popularity in Russia." The Daily Dot reached out to Facebook for comment but has not received a response. This article originally published at The Daily Dot here
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/* Reflection and Meta-Programming */ /* ERROR MESSAGES */ from simple.debugging.ErrorMessages from simple.util.Console errMsg = new ErrorMessages errMsgAttrs = __object_attributes(errMsg) for error in errMsgAttrs { errorValue = __get_attribute_value(errMsg,error) stderr.Printfc(ConsoleColor.DARKRED,error + " = " + errorValue + "\n") }
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Q: Not sure how to evaluate this series $\sum_{n=2}^\infty \frac{(-1)^n}{\ln(n)}$ Stumped on this absolute convergence problem! (Converge conditionally, absolutely, or diverges) $$\sum_{n=2}^\infty \frac{(-1)^n}{\ln(n)} $$ First, I try to do the absolute convergence test: $$\sum_{n=2}^\infty \left\lvert \frac{-1^n}{\ln(n)}\right\rvert = \sum_{n=2}^\infty \frac{1}{\ln(n)} $$ Not sure how to evaluate this series. Which test to use? A: The series fulfills the conditions of Leibniz alternating series and then it converges, but it doesn't converge absolutely since by comparison $$\frac1{\log n}\ge\frac1n$$ and the harmonic series diverges. A: You know that for $n\ge 1$, $\ln(n) \le n$ which in turn says that $\frac{1}{n}\le \frac{1}{\ln(n)}$. What does this tell you about the absolute convergence? As for conditional, think about the alternating series test.
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Obscurants are materials disseminated into the air to block or obscure the view of objects in an area by scattering, absorbing, or reflecting electromagnetic radiation. Obscurants may be designed to block or obstruct visible light, or other frequencies on the electromagnetic spectrum (e.g., infrared radiation). Traditionally, obscurant-emitting compositions, such as those comprising pyrotechnic compositions, exhibit undesirable properties such as high toxicity, high burn temperature which may cause undesired fire, inorganic residue build-up inhibiting emission of the obscurant, limited functional temperature range, low obscurant yield, humidity dependence, or a number of other shortcomings, making their use inefficient, or potentially hazardous to users.
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Castrovirreyna Province The Castrovirreyna Province is one of seven provinces located in the Huancavelica Region of Peru. The capital of this province is the city of Castrovirreyna. Geography The Chunta mountain range traverses the province. Some of the highest peaks of the province are listed below: Political division The province is divided into thirteen districts, which are: Arma (Arma) Aurahua (Aurahua) Capillas (Capillas) Castrovirreyna (Castrovirreyna) Chupamarca (Chupamarca) Cocas (Cocas) Huachos (Huachos) Huamatambo (Huamatambo) Mollepampa (Mollepampa) San Juan (San Juan) Santa Ana (Santa Ana) Tantara (Tantara) Ticrapo (Ticrapo) Ethnic groups The province is inhabited by indigenous citizens of Quechua descent. Spanish is the language which the majority of the population (77.20%) learnt to speak in childhood, 22.30% of the residents started speaking using the Quechua language (2007 Peru Census). See also Aknuqucha Chuqlluqucha Urququcha References Category:Provinces of the Huancavelica Region
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535 U.S. 909 PAZ-ZAMORAv.UNITED STATES. No. 01-8003. Supreme Court of the United States. March 4, 2002. 1 C. A. 4th Cir. Certiorari denied. Reported below: 21 Fed. Appx. 108.
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Celebrate Recovery Celebrate Recovery is not just for those who struggle with alcoholism, sexual addiction, and emotional dependence. It is also for the person who struggles with workaholism, the person who feels they are a slave to the approval of others, the leader who deals with issues of control. God is gracious, so you can be honest as well. Come experience a new level of His grace and truth at Celebrate Recovery! For more information or to sign-up for childcare go here.
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Modulation of attentional networks by food-related disinhibition. The risk of weight gain is especially related to disinhibition, which indicates the responsiveness to external food stimuli with associated disruptions in eating control. We adapted a food-related version of the attention network task and used functional magnetic resonance imaging to study the effects of disinhibition on attentional networks in 19 normal-weight participants. High disinhibition scores were associated with a rapid reorienting response to food pictures after invalid cueing and with an enhanced alerting effect of a warning cue signalizing the upcoming appearance of a food picture. Imaging data revealed activation of a right-lateralized ventral attention network during reorienting. The faster the reorienting and the higher the disinhibition score, the less activation of this network was observed. The alerting contrast showed activation in visual, temporo-parietal and anterior sites. These modulations of attentional networks by food-related disinhibition might be related to an attentional bias to energy dense and palatable food and increased intake of food in disinhibited individuals.
{ "pile_set_name": "PubMed Abstracts" }
Date School/Commentator Wed, Mar 8 Alabama Pro Day (live at noon ET) Studio: Peter Burns, Marcus Spears, Kevin Weidl Field analyst: Greg McElroy Kentucky Pro Day Tony Barnhart Fri, Mar 10 Auburn Pro Day Cole Cubelic Tue, Mar 14 South Carolina Pro Day* Tony Barnhart Wed, Mar 15 Arkansas Pro Day* Clint Stoerner Georgia Pro Day* Tony Barnhart Thu, Mar 16 Vanderbilt Pro Day Tony Barnhart Wed, Mar 22 Mississippi State Pro Day** Cole Cubelic Thu, Mar 23 Mizzou Pro Day Tony Barnhart Tue, Mar 28 Florida Pro Day Show (live at 10 a.m.) Studio: Tom Luginbill, Marcus Spears, Kevin Weidl Field Analyst: Booger Wed, Mar 29 Texas A&M Pro Day Show (live at 10 a.m.) Studio: Tom Luginbill, Marcus Spears, Kevin Weidl Field Analyst: Greg McElroy Fri, Mar 31 Tennessee Pro Day Tony Barnhart Mon, Apr 3 Ole Miss Pro Day Cole Cubelic Wed, Apr 5 LSU Pro Day Show (live at 10 a.m.) Studio: Peter Burns, Marcus Spears, Greg McElroy Field Analyst: Tom Luginbill GAINESVILLE, Fla. – SEC Network is sending reporters to all 14 SEC Football Pro Days this spring, broadcasting live from Florida's Pro Day on Tuesday, March 28. Commentators on-site are covering news and interviews from each event for SEC Network's evening news and information show SEC Now, and will begin with Kentucky and Alabama on Wednesday, March 8.In addition to SEC Now nightly news coverage, the network is also live from Alabama, Florida, LSU and Texas A&M Pro Days. Analysts Marcus Spears and Kevin Weidl will primarily be in studio, with Greg McElroy, Booger McFarland and Tom Luginbill on-campus.Pro Day events typically include weight room weigh-ins, bench press, vertical jump, broad jump as well as the 40-yard dash, 60-yard shuttle and position workouts for players entering the NFL Draft.
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See new values and premium to NYMEX on Annex 1.02. Tweaked slightly to agree with EPG adjustments for elimination of the Merlin SubNotes from the transaction.
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BANJUL (Reuters) - West African troops have extended their military mission in Gambia by one year after entering the country in January to force out longtime ruler Yahya Jammeh, regional bloc ECOWAS said on Monday. About 500 ECOWAS troops remain in Gambia of the original 7,000 that crossed over from neighboring Senegal to compel Jammeh to go into exile and leave the presidency to Adama Barrow, who defeated him in a December election. Soldiers from the mission, known as ECOMIG, came under attack last Friday by locals in Jammeh’s native village of Kanilai, Interior Minister Mai Ahmed Fatty said in a televised statement, underscoring unresolved tensions from Jammeh’s 22-year rule. One of the demonstrators demanding the departure of ECOMIG and state troops was killed in the clashes, and security forces made 22 arrests, Fatty said. The tiny country of 2 million people is trying to rebuild its economy and obtain justice for victims of Jammeh’s government, which is accused of torturing and killing perceived opponents. Separately, ECOWAS’s 15 member states gave preliminary approval to Morocco’s bid to join the bloc “because of (its) strong and multi-dimensional links of cooperation with West Africa”, ECOWAS said in a statement.
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The present invention relates to an exposure apparatus, and more particularly to an exposure apparatus that exposes an object, such as a single crystal substrate and a glass plate for a liquid crystal display (“LCD”). The present invention is suitable, for example, for an exposure apparatus that uses extreme ultraviolet (“EUV”) light, such as soft X-ray, for an exposure light source. In manufacturing such fine semiconductor devices as semiconductor memories and logic circuits in photolithography technology, reduction projection exposure apparatus have been conventionally employed which use a projection optical system to project a circuit pattern formed on a mask or a reticle onto a wafer, etc. to transfer the circuit pattern. Proximity exposure apparatuses have also conventionally been employed which directly transfer a circuit pattern on a reticle onto a wafer. The minimum critical dimension (“CD”) to be transferred by the projection exposure apparatus or resolution is proportionate to a wavelength of light used for exposure, and inversely proportionate to the numerical aperture (“NA”) of the projection optical system. The shorter the wavelength is, the better the resolution is. Recent demands for finer semiconductor devices have promoted a shorter wavelength of ultraviolet light from an ultra-high pressure mercury lamp (i-line with a wavelength of about 365 nm) to KrF excimer laser (with a wavelength of about 248 nm) and ArF excimer laser (with a wavelength of about 193 nm). The lithography using the ultraviolet light, however, has the limit to satisfy the rapidly progressing fine processing of semiconductor devices. Accordingly, there has been developed a reduction projection optical system using EUV light with a wavelength less than about 100 nm (referred to as an “EUV exposure apparatus” hereinafter) for clear transfers of very fine circuit patterns. The EUV light's wavelength is shorter than that of F2 laser (with a wavelength of about 157 nm) as the UV light. Absorptive materials, such as oxygen molecules, water molecules and carbon dioxide included in the air greatly absorb the optical energy of light in a wave range between 100 nm and 200 nm in the vacuum UV range, and thus such light has a difficulty in transmitting through the air. Accordingly, an exposure apparatus that uses ArF excimer laser and F2 laser as a light source needs to purge an optical path for the exposure light with inert gas, such as nitrogen and helium. In particular, the EUV exposure apparatus needs to maintain the optical path for the exposure light vacuum, because gas in the optical path absorbs and scatters the exposure light and prevents its transmissions. Since materials greatly absorb the light of a wave range of the EUV light, a refractive optical system (that utilizes lenses or refractions of light) for use with visual light and UV light is not viable because of the low transmittance of the EUV light to an optical element, such as a lens. Therefore, a catoptric optical system is used which utilizes reflections of light. An optical element for use with the catoptric optical element includes an oblique incidence total reflection mirror and a multilayer mirror. The wave range of the EUV light has a refractive index's real part of slightly smaller than 1, and is totally reflected by increasing an incident angle to introduce the light almost parallel to the reflective surface. The oblique incidence total reflection mirror utilizes this feature. Usually, the reflectance of 80% or greater is available to an oblique incidence with an angle between several degrees to 10° from the reflective surface (or an incident angle between a little larger than 70 and 90°). However, the oblique incidence total reflection mirror disadvantageously makes an optical system large due to little degree of freedom of the optical design cause by the limited incident angle. On the other hand, the multilayer mirror alternately layers two different types of thin films having different optical constants or refractive indexes, and can use an incident angle close to perpendicular incidence. Proper selections of materials for these thin films and the number of layers would increase the reflectance up to about 70%. The EUV exposure apparatus thus uses for a projection optical system a multilayer mirror that has larger degree of freedom than that of an oblique incidence total reflection mirror. An exposure apparatus needs an alignment between a reticle and a wafer in exposure, and includes plural alignment optical systems. FIG. 15 is a schematic structure of a conventional exposure apparatus 1000 that uses KrF excimer laser and ArF excimer laser etc. for an exposure light source. The alignment optical system can be roughly classified into two types, i.e., an off-axis optical detection system 1400 that detects an alignment mark on a wafer 1300 for use with a wafer alignment, and a Through The Reticle (“TTR”) alignment optical system 1500 that detects a position of an alignment mark on a reticle 1100 relative to the alignment mark on the wafer 1300 through a projection optical system. The TTR alignment optical system is sometimes referred to as a Through The Lens (“TTL”) alignment optical system. The off-axis alignment optical system 1400 serves to detect a position of the wafer 1300 for alignments of the wafer 1300 at a position different from an exposure position. Therefore, a precise alignment needs to maintain a baseline between the exposure position and the alignment position. Accordingly, the TTR alignment optical system 1500 needs to measure the baseline for alignments with higher precision than the baseline stability. The TTR alignment optical system 1500 introduces light from an exposure light source (not shown) into an illumination part 1520 through an optical fiber 1510, etc., illuminates an alignment mark on the reticle 1100, and forms an image of the alignment mark on the illuminated reticle 1100 onto an image pickup device 1550 while enlarging the image through an objective lens 1530 and a relay lens 1540. The TTR alignment optical system 1500 preferably uses a light source that has the same wavelength as an exposure wavelength, and usually employs an exposure light source. A light source can use non-exposure light, but this configuration undesirably needs to correct the chromatic aberration in the projection optical system 1200. The light that has transmitted through the reticle 1100 and the projection optical system 1200 illuminates an alignment mark on a wafer-side reference plate 1352. An image of the illuminated alignment mark is formed on the reticle 1100 via the projection optical system 1200, and an enlarged image is formed on the image pickup device 1550 through the objective lens 1530, the relay lens 1540, etc. Use of the exposure light would maintain the same imaging relationship between the alignment marks on the reticle 1100 and the wafer-side reference plate 1352, as that for the exposure-time, and enable the same optical system to simultaneously detect these marks. An exposure position of a pattern or a mark on the reticle 1100 can be measured with precision without being affected by the optical system's errors, etc. In addition, the baseline or an arrangement between the exposure position (or reticle mark) and a position of the off-axis alignment optical system 1400 can be assured by driving the wafer stage 1530 and detecting the alignment mark on the wafer-side reference plate 1352 through the off-axis alignment optical system 1400. Some TTR alignment optical systems illuminate an alignment mark on a wafer-side reference plate from a backside of the wafer-side reference plate (or an opposite side to the projection optical system) to form an image of the alignment mark on a reticle-side reference plate through a projection optical system, and illuminate the alignment mark on the reticle-side reference plate to image the transmitted light on an image pickup device. An alternative type makes alignment marks on a reticle and a wafer-side reference plate of repetitive patterns of a light-shielding part and a light-transmitting part. These patterns are different in size by a magnification of the projection optical system. This type illuminates the repetitive pattern on the reticle from a backside of the reticle (or backside of the projection optical system) to project the pattern onto the repetitive pattern on the wafer-side reference plate via the projection optical system, and detects the light that has transmitted through the wafer-side reference plate while moving the wafer stage. The TTR alignment optical system thus can detect a position of the wafer-side alignment mark relative to the reticle-side alignment mark, or a position of the reticle-side alignment mark relative to the wafer-side alignment mark. When the EUV exposure apparatus applies exposure light to the alignment optical system, the TTR alignment optical system cannot use a conventionally available refractive element, such as a lens, but use only mirrors to form an image of an alignment mark on an image pickup device. Therefore, a conventionally available compact optical system is inapplicable. In general, the alignment optical system forms an image of the alignment mark of twenty magnifications or greater on the image pickup device, and the enlarged magnification lowers the light intensity. For example, the alignment optical system of twenty optical magnifications lowers the light intensity on the reticle surface down to 1/400 on the image pickup device. Moreover, the multilayer mirror has reflectance of about 70% to the EUV light, posing a problem of efficiency or reflectance of the optical system: If the alignment optical system of twenty optical magnifications uses about ten multilayer mirrors, although the number of mirrors depends upon the permissible size of the alignment optical system, the reflectance becomes about 2.8%. On the other hand, the efficiency (or transmittance) of a lens-using alignment optical system in a conventional exposure apparatus is 90.5% when the alignment optical system uses ten lenses and each lens has reflectance of 0.5%. Therefore, the efficiency is 30 times as large as that for the EUV light. Therefore, the TTR alignment optical system that uses the EUV light cannot configure a detection system as high-magnification and precise as the prior art. Even without the enlargement optical system, a light-receiving sensor for detecting the EUV light would raises a durability problem. In addition, since the EUV exposure apparatus is stricter in overlay precision than the prior art, frequent calibrations with the TTR alignment optical system are required for baseline corrections, etc. However, an EUV light source requires a high running cost, and frequent calibrations would increase the cost.
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[Idiopathic calcinosis of the scrotum: a case report]. A 25-year-old man complained of painless, firm scrotal nodules which increased in number and size for the last 7 years. Physical examination was unremarkable except for many, firm painless nodules near the scrotal raphe. Preoperative diagnosis was multiple scrotal tumors of unknown etiology. Surgical excision was performed under epidural anesthesia. On microscopic examination, the nodules were located in the dermis and composed of calcified material which was positive with the von Kossa calcium stain. There were numerous foreign giant cells and dense fibrosis at the margins of the lesions. Idiopathic calcinosis of the scrotum was the final diagnosis. Although its etiology is unknown, the literature reviewed supported the view that the mast cell accumulation and its degranulation are related to idiopathic calcinosis of the scrotum.
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A memorable but disappointing first season. Dear Overwatch fans, I'd like to share my experience from the inaugural season of Overwatch League and tell the story of the ups and downs of being a player in SF Shock. First things first, I would really like to thank all of my teammates (sinatraa, super, nomy, babybay, moth, architect, iddqd, sleepy, danteh, nevix, choihyobin) for being supportive and helping me become a better player just by being awesome human beings. Next, I would like to thank every single staff member (Andy, Brett, Harsha, Jamie, Sephy, Legit, Junk, Crusty, NineK, Chris, Pizzas, David, JB, Derrick) for tolerating and helping us develop as players and individuals. Finally, a huge thanks to each OWL staff member, every fan that showed support in any way, the shock squad, Tyler, etc, etc, etc... without your help and support, it would have been infinitely harder. As the start of OWL season 1 approached, it was very evident that mercy/zen was going to be meta. In a team with a limited eligible roster of 6 players and pretty much zero experience playing mercy in scrims, I had to grind really hard to learn the hero as quickly as possible to not let my teammates down. The players and staff members that were with us during our Vegas phase know how hard I tried. Unfortunately, the conditions were not ideal for me to learn the role at the required speed. The evolution of a new dive and anti-dive meta with the lack of a comfortable projectile player made it particularly hard for me to figure out what my job was at all times. It wasn't until the end of stage one, with that match against Florida Mayhem where I got my first player of the match that I finally understood why my Mercy play was so lackluster. It was at that time when I realized the necessity of being a selfish player whenever I was on Mercy. See, the thing is, with pretty much all other support heroes in Overwatch, you have to try to remain alive while healing and supporting your teammates as much as possible. However, Mercy requires someone who cares about himself first, above all others, Zenyatta after, and then and only then, if able to bring teammates back to life, resurrect. If you ever play Mercy, and see teammates taking damage out of line of sight, and your body itches for you to go help your teammates, you are doing it wrong. Needless to say, this was against every single instinct I have as a player, those who have played with me at all know how good a teammate I can be in-game. And... that was it. With the introduction of Moth to the team, I was moved to a substitute position where my only goal was to learn from what moth did better than me (such as feed less and ult track) and try to incorporate said skills to my game. By far my biggest disappointment of season one is not having played a single minute on stage with sinatraa. I don't think I will ever find natural synergy with a player like I have with sinatraa, it's like we have the same mind, scary in a good way. Even at a time when sinatraa, babybay and me were playing internal scrims on team B and stomping team A, I still didn't get to play a single minute with him on stage. Even during our Vegas prep, it was fairly obvious our team would look a lot different once sinatraa and super could play stage 3 and after. It was a shame not to ever share the stage with those two. Not everything was bad about season one though. I learned a lot from spectating scrims and watching top-tier support player's point of view and top-down perspectives of team fights. It helped me to understand the game at a deeper level. I got to play against the best of the best during scrims and stage matches. I helped teammates and got helped from teammates and coaches countless times to improve each other as players and individuals. I shared great memories with every single member of the Shock family, we laughed and we got mad together. It was definitely an enlightening ride and I would do it again in a heartbeat. For those of you that not know, I've been playing video games since I was 3 years old until I was 17 - competing in cs since I was 9 until I was 17. At the age of 18, I picked up poker and became a professional poker player. Every time I would watch a cs major, my body would itch, telling me to go back to gaming. When I tried Overwatch for the first time, it was a wrap. Competing at the highest level of Overwatch is all I dreamed of. And I haven't shown the world what I'm capable of, so I'm not done yet. My biggest accomplishment this season was earning the respect of OWL season 1 champions ( https://www.youtube.com/watch?v=FNaV-5KuODs ) as a Lucio player. I do not think many Lucio players in the world can do stuff like this ( contest point because no one else can, evade dragonblade, build and turn the fight with a beat - https://plays.tv/video/5a9b3aedc833e60d2c/nasty-wr ) while being able to play Ana and other supports at a high level. I'm confident I can be an asset to any OWL team and look forward to keep doing what I love. My only focus right now is helping Team Spain do good in the World Cup. Looking forward to what the future has to offer, dhaK. Reply · Report Post
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How To Tell Your Boss ‘You Suck’ And Not Get Fired! Most of us don’t like our bosses. Getting a good boss is nothing short of a miracle. Your boss is like your family – you really don’t have a choice there. So, what do you do when you have a difficult boss? Of course, one part of you wants to storm into his cabin and give him a piece of your mind. But, what if he fires you after that? It is not what you say, but the way you say it matters. I know this sounds cliché, but it is true. Just a little bit of sugar coating never hurt anyone. So, how do you go about telling your boss that he is awful? It is not very difficult. You just have to be tactful. Here are a few tips that could help you. Know when to talk There is always a time for everything. Don’t rush into things. If you just barge into your boss’ cabin and demand an audience and then start berating him, you’ll be out of the office quicker than you can say ‘unfair’. You need to take a number of things into consideration before you decide to give your boss feedback, the most important being his mood. You never know if he has come to office after a huge argument with his wife. Gauge his mood. Even if he does enter in a foul mood, his mood will change for the better if he sees everything going on smoothly. When everything’s going fine, he’ll be open to suggestions and negative feedback. The lesser, the better One important thing about negative feedback is that it has to be short to be effective. Keep it as short as you can without missing out on getting the message across clearly. It’ll help to write down the points before you go and meet him. If you are giving feedback over an email, use bullet points. If you are talking over the phone, keep the written points handy. If you are giving the feedback in person, go carefully through your points before you go and face him. Don’t give a lot of details. If your boss cares enough, he will ask you for them. Then you can go ahead and give the details. Lessen the impact Whenever possible, intersperse you negative comments with positive ones. When you say, “You give me so much work that I can’t take it anymore”, you could also add something like “I love my work. I am happy doing what I am doing. But it does get too much most of the time”. But you don’t have to get overtly emotional about the positive points. You could add points about why you like working for the company and how you find the work challenging and riveting. He’ll like to hear things like that. Remember – It is not a blame game Well, in a manner it is. But, essentially, it is about you not liking certain aspects and finding certain aspects to be very daunting. State the problem you are facing, not what everyone else is also facing. If all of you are facing the same problems, then let them go and do the talking. You talk from your perspective and how the problem is affecting you. Also, don’t blame your boss. That does not display a good character. I am not being judgmental here, but that’s the way it is. Instead of saying, “You think I am competent enough to do challenging work”, say “I need work that is more challenging”. This is, of course, an example. Know what you are talking about If, by way of giving feedback, you wish to suggest some new methods of working, then you’ll have to first think of a lot of factors. You’ll have to consider whether the new method will actually work in that organization, and what changes will be required to maintain it. You’ll also have to take into account the fact that maybe this organization does not have systems that will adapt to the new method. Just because it worked somewhere else, does not mean it’ll work here. After all, what cures Martha may make Mario sick. Practice what you preach Before suggesting anything, try to do it yourself and see if it works. If you have a wonderful idea that’ll enhance productivity, do it yourself first. When your boss notices your increased productivity, he’ll ask you himself. If the idea is complex, chalk out a plan before you go and meet your boss. Your word is not etched in stone You might have some brilliant ideas and suggestions. But don’t expect them to be accepted like it’s the cure for cancer. Be ready for any rejections that your ideas may face. It is not a sure event (statistically speaking), but neither is it an impossible event. Being prepared will help you not feel extremely bad about rejections. Be a sport. You might come up with a better suggestion next time! You don’t have to take things lying down, but you also need to proceed with caution. Your relationship with your boss is always a very sensitive area. Do try out these tips and let us know! Sajan works for Jombay, a job site in India that helps job seekers find the right kind of employment opportunities. Like this: LikeLoading... Related About Leigh Langston I am the woman behind the Dangerous Lee Network and along with helping starving artists get fed I have published some of the best in DIY, How To and Top List content in 50+ categories as well as my short stories, poems, opinion essays and personal blogs. I am also the author of the safe sex erotica anthology, "Keep Your Panties Up and Your Skirt Down" and an eBook on the affects of colorism, The Half Series: When Black People Look White.
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Correspondence - Design of ladder-type SAW/BAW. This paper describes the design of RF SAW/ BAW filters with constant group delay. The band-pass LC filter is designed based on the traditional Bessel filter design. Then, LC resonators in the filter are replaced by SAW/BAW resonators with finite capacitance ratio γ. Finite γ generates passband ripples in the group delay. However, it is shown the ripples can be suppressed by optimal design of the SAW/BAW resonators. Norton's first transform is also applied to the designed filter to reduce variation of resonator shunt capacitances. Finally, extremely flat group delay with deviation of 4 ns over the frequency range of ±20 MHz at the center frequency of 1 GHz is theoretically demonstrated.
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Alex Rigopulos Alexander Peter "Alex" Rigopulos is an American video game designer and musician, best known as the former CEO and current creative director of Harmonix Music Systems, a company he founded with Eran Egozy in 1995. He is also a member of the band Newfane with his brother Chris Rigopulos. Career Rigopulos, born in Boxford, Massachusetts, is a graduate of Deerfield Academy along with two other brothers. He graduated with a B.S. in Music and Theater Arts in 1992 and an M.S. in Media Arts and Sciences in 1994 from the Media Lab at MIT. While there, he met Egozy, an electrical engineer, and they discovered ways to create interactive music devices. After they received their degrees, the two formed Harmonix to create music video games such as Frequency and Amplitude, but the company became highly successful with its contributions to both the Guitar Hero and Rock Band series of games, both which used specially designed controllers based on instruments like guitars and drum kits to mimic the playing of numerous rock songs. Rigopulos and Egozy were listed in Time Magazine's 2008 list of the 100 most influential people for their work on Rock Band. In May 2014, amid layoffs at Harmonix, Rigopulos announced that he would step down as CEO, being replaced by Steve Janiak, while he would become the chief creative officer for the company. Rigopulos personally cites Japanese game designers Masaya Matsuura, Tetsuya Mizuguchi, and Keita Takahashi as some artists that have inspired his work at Harmonix. In August 2010, Rigopulos joined the Advisory Board of The AbleGamers Foundation, a nonprofit dedicated to bringing the rich world of digital entertainment to people with disabilities. In September 2015, he joined the advisory board for the crowdfunding platform Fig. Rigopulos also donated $2,000 to the ScoreHero website, a website used to track Guitar Hero and Rock Band scores. He donated $9600 to the Colbert Super PAC in 2011. He was also one of the highest backers of the Kickstarter campaign for Double Fine Productions' Broken Age, which led to a character named Alex, loosely based on Rigopulos' own image and voiced by Rigopulos, being included in the game. In April 2015, rock band The Warning met their GoFundMe goal thanks in large part to Rigopulos. References External links Category:1970s births Category:Living people Category:Massachusetts Institute of Technology alumni Category:People from Boxford, Massachusetts Category:American technology chief executives Category:American people of Greek descent Category:Deerfield Academy alumni Category:Video game producers Category:Game Developers Conference Pioneer Award recipients
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Q: Stop other programs from minimizing my Win32 application I've got a Delphi app that is running in an environment where it gets minimized by another aggressive app that is trying to seize the screen entirely (it's POS stuff). When a second application is started it get hunts down the windows and minimizes them, probably by enumerating the windows and hitting them with a 'ShowWindow(handle,SW_MINIMIZE)'. It seems to me that the thing to do is to pick up these commands and block resize/minimize messages to the window. I've tried hacking around a few handlers to try and capture this behaviour, but still the SW_MINIMIZE will hide it. And Winsight is not showing me much other than the notification messages that something is resizing etc. I've put in a message handler for WMSysCommand messages, but that only seems to stop actions like the minimize button being clicked. And I've tried overriding the WndProc function to filter messages but that doesn't cut it either. If anyone could shed some light on what happens when the ShowWindow(handle,SW_MINIMIZE) call is inflicted on an application I'd be very grateful! Thanks Terry A: What happens when ShowWindow is called with SW_MINIMIZE as 'nCmdShow' is that the window manager minimizes the window. The system will send various notification messages, some more important to be able to carry out the minimization and the application can act upon, like WM_WINDOWPOSCHANGING, WM_GETMINMAXINFO, WM_NCCALCSIZE, or some just to notify, like WM_WINDOWPOSCHANGED, WM_MOVE, WM_SIZE, but normally, none of these is for blocking the operation. The cleanest way, I think, if you can decide that the minimization is unexpected, is to respond to a WM_SIZE message when 'wParam' is SIZE_MINIMIZED, and restore your window accordingly. Then your form will bounce back from the taskbar: type TForm1 = class(TForm) ... private procedure WmSize(var Msg: TWMSize); message WM_SIZE; end; procedure TForm1.WmSize(var Msg: TWMSize); begin inherited; if (Msg.SizeType = SIZE_MINIMIZED) and IsUnexpectedMinimize then PostMessage(Handle, WM_SYSCOMMAND, SC_RESTORE, 0); end; I don't have any clear idea about how you might decide either a minimization is unexpected or not but it would seem you do. User initiated actions would cause a WM_SYSCOMMAND to be send, but I don't know if some of the OS features also do that and you'll be able to differentiate if the OS minimizes the window or the aggressive application.
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use wasm_bindgen::prelude::*; #[wasm_bindgen(typescript_custom_section)] const TS_INTERFACE_EXPORT: &'static str = r" interface Height { height: number; } "; #[wasm_bindgen] pub struct Person { pub height: u32, }
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Influence of scaffold morphology on co-cultures of human endothelial and adipose tissue-derived stem cells. The interior of tissue engineering scaffolds must be vascularizable and allow adequate nutrients perfusion in order to ensure the viability of the cells colonizing them. The promotion of rapid vascularization of scaffolds is critical for thick artificial constructs. In the present study co-cultures of human endothelial and adipose tissue-derived stem cells have been performed in poly(ethyl acrylate) scaffolds with two different pore structures: grid-like (PEA-o) or sponge-like (PEA-s), in combination with a self-assembling peptide gel filling the pores, which aims to mimic the physiological niche. After 2 and 7 culture days, cell adhesion, proliferation and migration, the expression of cell surface markers like CD31 and CD90 and the release of VEGF were assessed by means of immunocytochemistry, scanning electronic microscopy, flow cytometry and ELISA analyses. The study demonstrated that PEA-s scaffolds promoted greater cell organization into tubular-like structures than PEA-o scaffolds, and this was enhanced by the presence of the peptide gel. Paracrine signaling from adipose cells significantly improved endothelial cell viability, proving the advantageous combination of this system for obtaining easily vascularizable tissue engineered grafts. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1523-1533, 2016.
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We started our podcast this year and we found this tool called My Podcast Reviews created by Daniel J. Lewis. It has saved us a ton of time and it’s been so helpful to us out. It’s so important to be visible in Apple and to be aware of the reviews there, but we’re Android users, so we were finding it difficult to tap into all the Apple Podcasts stores around the world to collect the reviews, in a timely manner. My Podcast Reviews is the perfect solution, because it sends us all of the reviews right to our email. It’s so important to get the feedback on our show and the various episodes, so we know what our listeners like and what our audience is looking for. So, a big thank you to Daniel for this very helpful tool. Paul & Jennifer Henczel The Inspiring Show
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import React from 'react'; import styles from 'components/Sidebar/Sidebar.scss'; export default ({ name, onClick }) => ( <div className={styles.currentApp} onClick={onClick}> {name} </div> );
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Q: TypeScript Recursive function returns undefined I have an array of Objects with the following structure: { Name: "Automotive" RefCategory: 1, ChildCategories:[{ Name: "Car" RefCategory: 2, ChildCategories: [] },{ Name: "Motorcycle" RefCategory: 3, ChildCategories: [] }] } I wrote a function to find a Category Node given its Ref: navigateToNode(node: any, RefCategoryToFind: number): any { if (node.RefCategory == RefCategoryToFind) return node; node.ChildCategories.forEach(value => { if (value.RefCategory == RefCategoryToFind) return value; else { if (value.ChildCategories.length !== 0) return this.navigateToNode(value, RefCategoryToFind); } }); } This function returns null when I call let x = this.navigateToNode(this.activeCategories[0], 2); I can see it hits the return value; and thus found the right node, but returns undefined. A: Your callback is returning a value, but the wrapping function does not return anything. Try saving the return value when it is found and return it: navigateToNode(node: any, RefCategoryToFind: number): any { if (node.RefCategory == RefCategoryToFind) return node; var result; node.ChildCategories.forEach(value => { if (value.RefCategory == RefCategoryToFind) { result = value; return value; } else { if (value.ChildCategories.length !== 0) return this.navigateToNode(value, RefCategoryToFind); } }); return result; }
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#define NAMESPACE namespace A NAMESPACE { int Foo; /* Test 1 */ // CHECK: int Bar; } int Foo; // CHECK: int Foo; int Qux = Foo; // CHECK: int Qux = Foo; int Baz = A::Foo; /* Test 2 */ // CHECK: Baz = A::Bar; void fun() { struct { int Foo; // CHECK: int Foo; } b = {100}; int Foo = 100; // CHECK: int Foo = 100; Baz = Foo; // CHECK: Baz = Foo; { extern int Foo; // CHECK: extern int Foo; Baz = Foo; // CHECK: Baz = Foo; Foo = A::Foo /* Test 3 */ + Baz; // CHECK: Foo = A::Bar /* Test 3 */ + Baz; A::Foo /* Test 4 */ = b.Foo; // CHECK: A::Bar /* Test 4 */ = b.Foo; } Foo = b.Foo; // Foo = b.Foo; } // Test 1. // RUN: clang-rename -offset=46 -new-name=Bar %s -- | sed 's,//.*,,' | FileCheck %s // Test 2. // RUN: clang-rename -offset=234 -new-name=Bar %s -- | sed 's,//.*,,' | FileCheck %s // Test 3. // RUN: clang-rename -offset=641 -new-name=Bar %s -- | sed 's,//.*,,' | FileCheck %s // Test 4. // RUN: clang-rename -offset=716 -new-name=Bar %s -- | sed 's,//.*,,' | FileCheck %s // To find offsets after modifying the file, use: // grep -Ubo 'Foo.*' <file>
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Q: Neo4j 2.0.1 graphstyle.grass for multiple labels I'm having a hard time setting properties for nodes with multiple labels. My graphstyle.grass file looks like this: node { diameter: 40px; color: #aaaaaa; border-color: #888888; border-width: 1.5px; text-color-internal: #000000; caption: '{name}'; font-size: 12px; } node.foo { color: #aaaaff; } node.bar { color: #aaffaa; } node.bar.a { border-color: #ff0000; } node.bar.b { border-color: #0000ff; } So the intention here is that if you have a label of 'bar' the node is colored a certain way, if you also have an additional label of 'a' or 'b' your border is colored appropriately. My CSS knowledge is weak but I think this is traditionally how multiple class selectors are done. The behavior I'm seeing in the Neo 2.0.1 browser graph display is that if a node has multiple labels, it picks the first label, tries to find a node.first_label selector in the grass file, if it doesn't find it it just adds a new selector for it. So two concrete examples: If there's a node with labels ['bar','a'] (in that order) then Neo4j will find the node.bar selector above and use it, not doing anything with the second class.. i.e. the 'node.bar.a' attributes won't be applied. If the node has the labels ['a','bar'] (in that order) then Neo4j will look for a selector of the form 'node.a' and not invoke any of the selectors above but instead create a new selector with a set of default parameters. Any guidance or suggestions are greatly appreciated. A: That's a perfectly sensible approach, which would be correct. As of Neo4j 2.0.1, the graph stylesheets aren't yet clever enough to handle chained class selectors. The order of selection is (as you've observed) also broken. update: As of 2.2, multiple class selectors are supported, as long as you edit the grass definition by hand.
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(Take them out of the folder they came zipped in and place in tools.) 5. Double-click and run doroot.bat 6. Let it run. 7. It will let you know if it has finished completely. 8. Reboot your phone and you are rooted! If these instructions don’t. Which version of Java is required to run Apache Ant? You will need Java installed on your system, version 1.8 or later required. Cannot run program "C:\Program Files\MPlayer for Windows": CreateProcess error=5, Access is denied
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Postexercise oxygen consumption in trained females: effect of exercise duration. Many research studies report the long-lasting elevation of metabolism following exercise. However, little is known regarding the impact of duration and intensity on this phenomenon, particularly in trained women in whom the time of the menstrual cycle has been controlled. This study examined the effects of a constant walking intensity (70% of maximal oxygen uptake (VO2max)) on the treadmill at various levels of duration (20, 40, and 60 min) on 3-h recovery of oxygen uptake (VO2). Eight trained (mean +/- SD) (VO2max = 47.6 +/- 3.2 ml.kg-1.min-1) females (mean age = 30.2 +/- 5.0 yr, mean weight = 58.7 +/- 7.6 kg, mean height = 165.6 +/- 7.0 cm) participated in the study. Subjects reported to the lab for a maximal oxygen consumption test and returned on four additional occasions (control, 20, 40, 60 min) in random fashion. Treadmill speed and grade were established to yield the appropriate intensity for each subject. Following each exercise bout subjects sat quietly for a 3-h time period. Variables measured included VO2, minute ventilation (VE), respiratory exchange ratio (RER), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and core (rectal) temperature (Tc). Variables were measured each 15 min of recovery. An ANOVA was used to assess differences due to duration. Excess postexercise oxygen consumption (EPOC) was calculated by subtracting the resting VO2 from the absolute VO2 and summing the individual EPOCs during each 3-h postexercise session and comparing these individual values to the preexercise VO2 values. The EPOC was significantly elevated (P < 0.05) in each of the three durations as compared with the control (sitting) and preexercise periods. The total EPOC was significantly higher for the 60-min duration (15.2 l) as compared with either 20-min (8.b l) or 40-min (9.8 l) duration (P < 0.05). This was observed without significant changes in VE, RER, HR, SBP, DBP, or Tc. Additionally, there were no differences during exercise across the three durations in VO2, VE, RER, HR, SBP, DBP, or Tc. These data suggest that exercise duration increases EPOC significantly and that a 60-min duration yields approximately twice the EPOC than either 20 or 40 min.
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\name{golden-class} \docType{class} \title{Class \code{"golden"} and Generator for Golden Search Optimizer Class} \alias{golden-class} \alias{golden} \description{ \code{"golden"} is a reference class for a golden search scalar optimizer, for a parameter within an interval. \code{golden()} is the generator for the \code{"golden"} class. The optimizer uses reverse communications. } \usage{ golden(...) } \arguments{ \item{\dots}{(partly optional) arguments passed to \code{\link{new}()} must be named arguments. \code{lower} and \code{upper} are the bounds for the scalar parameter; they must be finite.} } \section{Extends}{ All reference classes extend and inherit methods from \code{"\linkS4class{envRefClass}"}. } \examples{ showClass("golden") golden(lower= -100, upper= 1e100) } \keyword{classes}
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Pages Wednesday, February 27, 2013 On Raids and Handcuffs One Year Later One year ago today I was awakened to the crashing sound of my front door being battered in, screams of "Police, hands up" and dark figures in my bedroom with guns drawn. Just writing that sentence still takes my breath away. Never in my wildest imagination could I anticipate that this could or would happen to me. I sometimes thought of the possibility of the police executing a search warrant because of my ex-husband's online search for pornographic images of children. But to break down my door with an army of officers with guns drawn? This was preposterous to me then and still is. My ex-husband was not suspected as a terrorist, murderer or rapist. The use of extreme force in our situation stuns me still. I pulled my robe around my shaking body as I was escorted from my bedroom to my dining room table, where my daughter was already seated with an officer at her side. I waited while the "army" went to my husband's room and woke him up. He had slept through the melee that intruded on our home prior to the sun coming up. They brought him downstairs and sat him at the breakfast table where his interrogation began. A detective introduced himself and waived the search warrant at me but refused to allow me to read it. He began questioning my daughter and I about internet file sharing and when we asked him what that was, seemed satisfied that we were not participants in the crimes he was investigating. So we sat for hours, with at least one officer with us at all times. I had to ask for a glass of water, in my own home; I had to ask permission to go to the bathroom and then be escorted by an officer, in my own home. I had to ask for my glasses, still by my bedside, I could not just go and get them. I watched as hordes of officers tracked mud through my home--carting boxes in and out. I was not allowed to have my phone until it had been cleared by the computer forensic team so had no way of reaching out to anyone. This was America, was it not? How could this possibly be happening to me. It seems surreal still. The detectives returned the next day and placed my ex-husband under arrest. Standing beside my distraught daughter in our foyer, I watched as they placed handcuffs on him and listed the charges against him. I watched as they walked him out the front door and placed him in the squad car. I watched as the car sped away and knew the familiar route they would take to the county jail, a short ten minutes away. I watched, still in disbelief and shock. For all my fears and concern about his involvement in child pornography, I never imagined this day. The past year has been so difficult; his criminal case is still unfolding, our divorce, a nightmarish experience, has been finalized, and my kids and I have struggled to work through the devastation visited upon us. Not often, but sometimes, I find myself seeing the experience through my ex-husband's eyes. His career has been destroyed, his freedom is very much at stake, he is estranged from his children and he faces certain financial ruin. I feel tremendous empathy for him, which is better than the bitterness and anger I have been consumed by for far too many months. But today, I can't get the image of him being placed in handcuffs out of my mind; today the memories of the raid are so fresh and real and still traumatic. When I remember the sweet man I thought I knew, I grieve even more for the very sick man he has become. And I see the handcuffs as a symbol of the disease or obsession or compulsion of addiction that has bound him for most of his life. Today I will pause and remember and then be grateful. In the past twelve months, I have learned that gratitude has the power to demolish fear and anxiety and from a trauma perspective helps ground me in the present rather than in the memories of those traumatic moments. Today I am grateful that the knot I lived with in the pit of my stomach for over three decades has disintegrated. Today I am grateful for healing that is evident in my own life and in my children's lives. Today I am grateful for life and possibilities, for the warm breezes that blow through my window and through my life. Today I am alive and I am free, for that I give thanks. 2 comments: My heart breaks for you. I cant imagine how painful this must have been for you and your children. I would bet it would be even harder to say good bye to the life and a love you thought you had with a man who never let you know him. It is my hope that you will in time heal and that you will find the joy and happiness God truly wants you to have. Thank you so very much, Jennifer. Healing is occurring--it just takes time. I am learning that you cannot force or rush it but rather must allow it to unfold in at its own pace. But I appreciate your kind thoughts.
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By Jake Donovan The proposed middleweight title eliminator between Sergiy Derevyanchenko and Jack Culcay might not head to Germany after all. Lou DiBella, Derevyanchenko’s promoter secured the rights to the International Boxing Federation (IBF)-ordered final eliminator during a purse bid hearing held Tuesday afternoon at the sanctioning body’s New Jersey headquarters. The New York-based promoter offering a winning bid of $425,515 to secure the rights to the forthcoming bout. The lone other bidder during Tuesday’s session was AGON Sports, Culcay’s promoter who talked a good game beforehand of bringing the bout to Germany. However, the Berlin-based outfit left the fate of its fighter in the hands of the enemy after falling well short with its $397,713 offering. Assuming both parties sign off, the middleweight clash is tentatively due to take place in early spring somewhere in the U.S. The winner will become the mandatory challenger to current titlist Daniel Jacobs, who won the vacant crown in a 12-round split decision win over Derevyanchenko—his training stablemate—last October at Hulu Theatre in New York City. The vacant title fight left the first two contender slots open in the 160-pound division, a traditional practice by the IBF who will not rank a number-one contender through any other means than resolution from a final elimination bout. Culcay (25-3, 13KOs)—who represented Germany in the 2008 Olympics—became the highest rated contender to such a bout on the heels of three straight victories at middleweight following back-to-back losses in the super welterweight division. His most recent win came last September, a 10th round knockout of Rafael Bejeran in an IBF regional title fight which was taken with the intention of next fighting in a title eliminator. In making the happen, a promise was kept by AGON Sports, which was formed in October 2017 and added Culcay as one of its first boxing clients last February. The entirety of Culcay’s three-fight win streak has come while fighting under the AGON banner. Derevyanchenko (12-1, 10KOs) has not fought since the aforementioned loss to Jacobs. A member of the 2008 Ukraine Olympic team, the squat middleweight relocated to Brooklyn prior to the start of his pro career, where he shares a head trainer with Jacobs in noted New York City coach Andre Rozier. An aggressive push to the title stage led him to an Aug. ’17 final eliminator with Tureano Johnson, whom Derevyanchenko handled en route to a 12th round knockout to become the mandatory contender to then-champ Gennady Golovkin. A stay-busy win over Dashon Johnson last March came about only because of Golovkin’s plans changing in the wake of a planned voluntary defense—a rematch with Saul ‘Canelo’ Alvarez—stalled after the Mexican tested positive for clenbuterol. The IBF granted Golovkin a replacement for the voluntary defense, with the condition that he next face Derevyanchenko who was permitted an interim bout for the sake of remaining active. Golovkin went on to crush miserably overmatched Vanes Martirosyan in two rounds but vacated his IBF title in favor of a Sept. rematch with Alvarez, losing the fight and all of his remaining titles. The final eliminator between Culcay and Derevyanchenko was initially ordered by the IBF on December 8. Culcay’s side was apparently a bit too overconfident in believing they could secure the rights to the event, as negotiations never really got off the ground and the two sides forced to wait out the January 15 purse bid hearing as a result. A win of sorts for Culcay comes in the final purse split. Thanks a new rule instituted by the IBF, the higher-rated challenger for any sanctioned eliminator is entitled to the favorable end of a 65/35 purse split. Culcay is the IBF’s #2 contender, one spot ahead of Derevyanchenko.
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State of the ACT Evidence ACT is committed to a high standard of empirical evaluation. This includes not just controlled assessment and evaluations of outcomes but also the specification and evaluation moderations and of the putative processes of change. Furthermore, we also seek to understand the links between these processes of change and basic functional behavioral principles, including those drawn from RFT. One web page is unable to collect together the growing evidence for all of the above areas at one time point or to keep it up to date going forward. More modestly, the three sections below aim to provide information on: 1. Organizations that describe ACT, or areas of ACT, as evidence based 2. Links to peer reviewed assessments of the ACT evidence base 3. Snapshots of the ACT RCT evidence base (a list of actual randomized controlled trials can be found at another page: https://contextualscience.org/ACT_Randomized_Controlled_Trials; a list of mediational studies can be found at This page will be updated approximately once every six months. Date of late update: January 2019. If you are aware of missing data, please contact the ACBS staff: acbsstaff@contextualscience.org 1. Organizations that describe ACT, or areas of ACT, as evidence based: A number of different organizations, external to ACBS, have stated that ACT is empirically supported in certain areas or as a whole according to their standards. These include: ii. SAMHSA's National Registry of Evidence-based Programs and Practices, ACT, last review July 2010. 2. Links to peer reviewed assessments of the ACT evidence base: Below is a list of meta-analyses, systematic or narrative reviews of the ACT evidence base, either overall or in specific areas. They are presented in reverse chronological order, by year of publication. The cummulative number of meta-analyses of the ACT literature is growing rapidly and will likely hit 50 by the end of 2019 (a graphic of the growth is attached as a JPEG file at the bottom of this page) In Press 45. Yıldız, E. (in press). The effects of acceptance and commitment therapy in psychosis treatment: A systematic review of randomized controlled trials. Perspectives in Psychiatric Care. DOI: 10.1111/ppc.12396 Full Text: Available Through DOI 35. Collins, R. N., & Kishita, N. (2018). The effectiveness of mindfulness- and acceptance-based interventions for informal caregivers of people with dementia: A meta-analysis. The Gerontologist, gny024. DOI: 10.1093/geront/gny024 Full Text: Available Through DOI 3. Mediational analyses ACT is a process-oriented approach and the list of studies testing mediation or moderation is quite large. As of Spring 2016 we were aware of approximately 45 mediational studies. This list is rapidly growing. A partial list can be found here (a child page to this webpage). 4. Qualitative Research After the first three RCTs in the early 1980's ACT research turned toward transcript analysis and qualitative research. Examples are the first ACT dissertations done at the Univeristy of Nevada by Sue McCurry and Durriyah Khorakiwala. This work in turn lead to the first item set for the AAQ, and to the commonly used ACT adherence measures, in addition to the protocol described in the first ACT book in 1999. Qualitative work is hard to do but it has continued throughout the ACT research program. Examples can be found here (a child page to this webpage). If you find any more send them to ACBS staff to add to the list. 5. Snapshots of the ACT RCT evidence base: As of May 2019, there are 304 randomized controlled trials (RCTs) of ACT published. Details of each of these studies, along with links to the original research articles, can be found here (a child page to this webpage). Below, we provide a snapshot of this ACT RCT evidence-base, summarizing clinical areas in order of the number of published RCTs. This list is current as of May 2019. It is, of course, acknowledged that evidence from RCTs is only one part of evidence-based practice, and for some questions and issues it is arguably not the most important. Mailing Address Socialise This website uses cookies to offer you a better browsing experience, personalize content, and analyze site traffic. To learn more about our policies and how we use cookies please read our Privacy Policy and Use of Cookies. ✖ OK
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Thomas McCabe (United Irishmen) Thomas McCabe (1739 - 1820) was a founding member of the Society of the United Irishmen, a revolutionary organisation in late 18th century Ireland. Early Life & Family A native of Belfast and member of the First Presbyterian Church, McCabe owned a cotton mill and a clock making shop in the city. Along with other future United men, such as Henry Haslett and William Tennant, he was a Freemason and a member of Lodge 684. He married Jean Woolsey, daughter of John Woolsey, a merchant of Portadown and together they had four children. Their third child was William Putnam McCabe,a fellow Freemason, who would also join the United Irishmen, and was important in organising Ulster prior to the 1798 Rebellion. Jean died in 1790. Industrialist & Abolitionaist Thomas was one of the founding members of the Belfast Charitable Society, Clifton House, Belfast in 1774. In the 1770s, McCabe and John McCracken (father of United Irishman Henry Joy McCracken) installed machinery in the Clifton House, known then as Belfast Poor House, enabling it to become the first cotton spinning mill in the town. An important member of Belfast's mercantile and industrial middle class, he donated £100 to the building of a new White Linen Hall in 1782, to act as a centre for the bustling linen industry in the city. Another important benefactor to the building of the hall, was fellow future United Irishman, Gilbert McIlveen. Prior to the founding of the United Irishmen, McCabe was heavily involved in Belfast's liberal and radical community, being a leading figure in the city's anti-slavery circle. He clashed routinely with the plans of Waddell Cunningham and others to form a Belfast-based slave trading company of which he wrote, ‘May God eternally damn the soul of the man who subscribes the first guinea’. In 1786, he prevented a slave-owning shipping company from setting up business in Belfast. These exploits led Theobald Wolfe Tone to style him as the 'Irish Slave'. The United Irishmen The United Irishmen were initially founded as a group of liberal Protestant and Presbyterian men interested in promoting Parliamentary reform, and later became a revolutionary movement influenced by the ideas of Thomas Paine and his book ‘The Rights of Man’. In 1791 Wolfe Tone published the pamphlet ‘Argument on Behalf of the Catholics of Ireland’ where he set out that religious division was being used to balance “the one party by the other, plunder and laugh at the defeat of both.” He put forward the case for unity between Catholic, Protestant and Dissenter. This pamphlet was read by McCabe and a group of eight other prominent Belfast Presbyterians interested in reforming Irish Parliament. They invited Tone and his friend Thomas Russell to Belfast where the group met on October 14, 1791. It was there that the Belfast Society of the United Irishmen was formed, with McCabe as a founding member. 1798 Rebellion and later life In March 1798, most of the leadership of the Leinster branch of the Society were meeting at the house of Oliver Bond in Dublin, when they were arrested. This crippled the organisation. Many of its leaders, such as Russell and Thomas Addis Emmet were already in prison, while others like Tone and Arthur O'Connor were in Europe. Meanwhile, Lord Edward Fitzgerald was in hiding, with a government net closing around him. Nonetheless, in May, the rising finally began. First in Kildare, it spread to other counties in Leinster before finally consuming Ulster. The meetings to plan the attack on Antrim were held in McCabe's house. During and after the insurrection, his shop in North St was repeatedly attacked by government troops. His son, William, acted as bodyguard to Lord Edward before his capture, and escaped to France after the revolution. At the age of 59, Thomas would have been too old to fight. Although still highly involved in the organisation during the insurrection, he appears to have been unmolested by the authorities in the aftermath. William later was involved in the uprising of Robert Emmet in 1803. Thomas is buried in Clifton Street Cemetery along with other prominent United men such as Henry Joy McCracken, William Drennan, William Steel Dickson, the Sinclair brothers. Notes References Marianne Elliott 2012, Wolfe Tone Second edition, Liverpool University Press John McCabe 1999, A United Irish Family: The McCabes of Belfast (Part III), 'North Irish Roots' Vol. 10, No. 1 (1999), pp. 33–35 Northern Ireland.org, Hidden Connections: The Abolitionist Movement in Ireland, (http://www.culturenorthernireland.org/article/103/hidden-connections-the-abolitionist-movement-in-ireland) Kenneth L. Dawson 2003, Moment of unity - Irish rebels and Freemasons, 'Irish News', May 10, 2003 Raymond O'Regan & Arthur Magee 2014, 'The Little Book of Belfast', The History Press Raymond O'Regan 2004, The history of Belfast's Exchange & Assembly Rooms, 'Your Place & Mine', June 2004. Kenneth Leslie Dawson 2004, McCabe, William Putnam (c. 1776-1821), Irish nationalist and cotton manufacturer, Oxford Dictionary of National Biography Category:1739 births Category:1820 deaths Category:United Irishmen Category:Irish Presbyterians Category:Irish Freemasons
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/* * Linux driver for digital TV devices equipped with B2C2 FlexcopII(b)/III * flexcop-reg.h - register abstraction for FlexCopII, FlexCopIIb and FlexCopIII * see flexcop.c for copyright information */ #ifndef __FLEXCOP_REG_H__ #define __FLEXCOP_REG_H__ typedef enum { FLEXCOP_UNK = 0, FLEXCOP_II, FLEXCOP_IIB, FLEXCOP_III, } flexcop_revision_t; typedef enum { FC_UNK = 0, FC_CABLE, FC_AIR_DVBT, FC_AIR_ATSC1, FC_AIR_ATSC2, FC_AIR_ATSC3, FC_SKY_REV23, FC_SKY_REV26, FC_SKY_REV27, FC_SKY_REV28, } flexcop_device_type_t; typedef enum { FC_USB = 0, FC_PCI, } flexcop_bus_t; /* FlexCop IBI Registers */ #if defined(__LITTLE_ENDIAN) #include "flexcop_ibi_value_le.h" #else #if defined(__BIG_ENDIAN) #include "flexcop_ibi_value_be.h" #else #error no endian defined #endif #endif #define fc_data_Tag_ID_DVB 0x3e #define fc_data_Tag_ID_ATSC 0x3f #define fc_data_Tag_ID_IDSB 0x8b #define fc_key_code_default 0x1 #define fc_key_code_even 0x2 #define fc_key_code_odd 0x3 extern flexcop_ibi_value ibi_zero; typedef enum { FC_I2C_PORT_DEMOD = 1, FC_I2C_PORT_EEPROM = 2, FC_I2C_PORT_TUNER = 3, } flexcop_i2c_port_t; typedef enum { FC_WRITE = 0, FC_READ = 1, } flexcop_access_op_t; typedef enum { FC_SRAM_DEST_NET = 1, FC_SRAM_DEST_CAI = 2, FC_SRAM_DEST_CAO = 4, FC_SRAM_DEST_MEDIA = 8 } flexcop_sram_dest_t; typedef enum { FC_SRAM_DEST_TARGET_WAN_USB = 0, FC_SRAM_DEST_TARGET_DMA1 = 1, FC_SRAM_DEST_TARGET_DMA2 = 2, FC_SRAM_DEST_TARGET_FC3_CA = 3 } flexcop_sram_dest_target_t; typedef enum { FC_SRAM_2_32KB = 0, /* 64KB */ FC_SRAM_1_32KB = 1, /* 32KB - default fow FCII */ FC_SRAM_1_128KB = 2, /* 128KB */ FC_SRAM_1_48KB = 3, /* 48KB - default for FCIII */ } flexcop_sram_type_t; typedef enum { FC_WAN_SPEED_4MBITS = 0, FC_WAN_SPEED_8MBITS = 1, FC_WAN_SPEED_12MBITS = 2, FC_WAN_SPEED_16MBITS = 3, } flexcop_wan_speed_t; typedef enum { FC_DMA_1 = 1, FC_DMA_2 = 2, } flexcop_dma_index_t; typedef enum { FC_DMA_SUBADDR_0 = 1, FC_DMA_SUBADDR_1 = 2, } flexcop_dma_addr_index_t; /* names of the particular registers */ typedef enum { dma1_000 = 0x000, dma1_004 = 0x004, dma1_008 = 0x008, dma1_00c = 0x00c, dma2_010 = 0x010, dma2_014 = 0x014, dma2_018 = 0x018, dma2_01c = 0x01c, tw_sm_c_100 = 0x100, tw_sm_c_104 = 0x104, tw_sm_c_108 = 0x108, tw_sm_c_10c = 0x10c, tw_sm_c_110 = 0x110, lnb_switch_freq_200 = 0x200, misc_204 = 0x204, ctrl_208 = 0x208, irq_20c = 0x20c, sw_reset_210 = 0x210, misc_214 = 0x214, mbox_v8_to_host_218 = 0x218, mbox_host_to_v8_21c = 0x21c, pid_filter_300 = 0x300, pid_filter_304 = 0x304, pid_filter_308 = 0x308, pid_filter_30c = 0x30c, index_reg_310 = 0x310, pid_n_reg_314 = 0x314, mac_low_reg_318 = 0x318, mac_high_reg_31c = 0x31c, data_tag_400 = 0x400, card_id_408 = 0x408, card_id_40c = 0x40c, mac_address_418 = 0x418, mac_address_41c = 0x41c, ci_600 = 0x600, pi_604 = 0x604, pi_608 = 0x608, dvb_reg_60c = 0x60c, sram_ctrl_reg_700 = 0x700, net_buf_reg_704 = 0x704, cai_buf_reg_708 = 0x708, cao_buf_reg_70c = 0x70c, media_buf_reg_710 = 0x710, sram_dest_reg_714 = 0x714, net_buf_reg_718 = 0x718, wan_ctrl_reg_71c = 0x71c, } flexcop_ibi_register; #define flexcop_set_ibi_value(reg,attr,val) { \ flexcop_ibi_value v = fc->read_ibi_reg(fc,reg); \ v.reg.attr = val; \ fc->write_ibi_reg(fc,reg,v); \ } #endif
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407 F.Supp.2d 41 (2005) PANNONIA FARMS, INC., Plaintiff, v. RE/MAX INTERNATIONAL, INC., et al., Defendants. No. Civ. 01-1697(RJL). United States District Court, District of Columbia. March 21, 2005. *42 *43 Bernard C. Dietz, Washington, DC, for Plaintiff. Elizabeth B. Sandza, Leboeuf, Lamb, Greene & Macrae, L.L.P., Jon Lellenberg, Randolph D. Moss, Wilmer Cutler Pickering LLP, Thomas P. Olson, Wilmer, Cutler & Pickering Hale & Dorr, John M. Collins, Washington, DC, John R. Posthumus, Greenberg Traurig, LLP, Denver, CO, for Defendants. MEMORANDUM OPINION AND ORDER LEON, District Judge. [# 7, # 8, # 24, # 26, # 27] Before the Court are Defendant Re/Max International, Inc.'s ("Re/Max") and Jon Lellenberg's motions to dismiss, supplemental motions to dismiss, and motion for attorneys' fees. Pannonia Farms, the plaintiff, allegedly holds the exclusive rights to nine of the Sherlock Holmes stories written by Sir Arthur Conan Doyle, which still enjoy copyright protection. Compl. ¶¶ 4, 8. Not unexpectedly, the ownership of those rights is determined by a lengthy chain of title, during which the rights have changed hands many times. Id. ¶¶ 10-14. In its complaint seeking relief from violations of the copyright and trademark laws, Pannonia Farms based its exclusive rights in the Sir Arthur Conan Doyle works on a transfer made to it by Star Container Entertainment ("Star Container") in 1986. Compl. ¶¶ 4, 14. The preliminary, but overarching, issue in this case is whether Pannonia Farms has a sufficient ownership interest in Sir Arthur Conan Doyle's works to have standing to sue for intellectual property violations. Defendants argue that a recent decision,[1] by the United States District Court for the Southern District of New York, holding that Pannonia Farms lacks standing to sue for violations of intellectual property rights, collaterally estops the plaintiff from bringing the action in this case. The Court agrees, and there being no basic unfairness to the plaintiff in applying that holding here, GRANTS the defendants' supplemental motions to dismiss. ANALYSIS Under Federal Rule of Civil Procedure 12(b)(6), a district court should dismiss a complaint for failure to state a claim upon which relief can be granted when it is clear that no relief could be granted under any set of facts consistent with the complaint's allegations. Conley v. Gibson, 355 U.S. 41, 45-46, 78 S.Ct. 99, 2 L.Ed.2d 80 (1957); EEOC v. St. Francis Xavier Parochial School, 117 F.3d 621, 624 (D.C.Cir.1997). All well-pleaded allegations are presumed to be true. Warren v. D.C., 353 F.3d 36, 39 (D.C.Cir.2004). Under the doctrine of collateral estoppel, however, it is elementary that "once an issue is actually and necessarily determined by a court of competent jurisdiction, that determination is conclusive in *44 subsequent suits based on a different cause of action involving a party to the prior litigation." Montana v. United States, 440 U.S. 147, 99 S.Ct. 970, 59 L.Ed.2d 210 (1979). Our Circuit Court has established a three-part test to determine whether a prior judgment is preclusive: First, the same issue now being raised must have been contested by the parties and submitted for judicial determination in the prior case. Second, the issue must have been actually and necessarily determined by a court of competent jurisdiction in that prior case. Third, preclusion in the second case must not work a basic unfairness to the party bound by the first determination. Yamaha Corp. v. United States, 961 F.2d 245, 254 (D.C.Cir.1992) (internal citations omitted). For the following reasons, the Court finds that this test is satisfied and collateral estoppel applies. Applying the first prong of the Yamaha test, the Court readily concludes that the issue before this Court, whether Pannonia Farms has standing to sue for violations of its intellectual property rights in the nine remaining Sherlock Holmes stories that still have copyright protection, was previously contested by the plaintiff and submitted for judgment in a federal district court in New York. That court determined, in Pannonia I, and affirmed in Pannonia II, that Pannonia Farms did not have standing to bring a suit against USA Cable because Pannonia Farms was bound by a 1990 Settlement Agreement between its president,[2] Andrea Reynolds, Andre Milos, Ms. Reynold's father, and Sheldon Reynolds, which provided that after the 1985 conveyance from Lady Duncan to Star Container "no enforceable assignments by any of the foregoing names mentioned in this paragraph [including Andrea Reynolds] was made thereafter." Pannonia I, 2004 WL 1276842, *2-3. The New York federal court considered the parties' arguments and rejected Pannonia Farms's contentions that: (1) it acquired ownership rights to Sir Arthur Conan Doyle's works in a 1986 transfer of rights from Star Container to Pannonia Farms; and (2) it was not a party to the Settlement. Id. at *5-6. Indeed, the court specifically held that Andrea Reynold's assent to the settlement agreement implicated Pannonia Farms, even though it was not a signatory to the agreement. Id. at *6. Moreover, Judge Buchwald concluded that because the Settlement Agreement "plainly extinguished" the 1986 assignment to Pannonia Farms, the corporation lacked standing because it did not own the copyrights, trademarks, and related rights. Id. Thus, the standing issue in this case is identical to the issue already contested, submitted, and decided by the New York federal court. Accordingly, the first element of the Yamaha test is satisfied. The satisfaction of the second requirement is equally clear. The issue of standing was "actually and necessarily" determined by a court of competent jurisdiction in the Southern District of New York. In Pannonia I, the court examined the 1990 Settlement Agreement thoroughly and found that Pannonia Farms lacked standing because the parties included the qualifying *45 language, "no enforceable assignment," in the agreement, which meant that either at least one party knew of the transfer from Star Container to Pannonia Farms or that "the parties contemplated the possibility that a conveyance about which they were unaware may have occurred," both of which indicated that any transfers after 1985 were unenforceable. Id. at *5. Pannonia Farms argues that the New York federal court "did not address the trademark issues relying on its finding that Pannonia Farms . . . was not a proper party plaintiff." Opp. to Lellenberg Supp. Mot. to Dismiss at 2. In Pannonia I, however, the court ruled "as a matter of law" that Pannonia Farms does not "own[] the copyrights, trademarks and related rights in the works of Sir Doyle." Pannonia I, 2004 WL 1276842, at *6 n. 15 (emphasis added). This Court finds that the Southern District of New York federal court thoroughly investigated the effect of the 1990 Settlement Agreement on Pannonia Farms's ownership interests in Pannonia I, and reconsidered the issue in Pannonia II. Therefore, a court of competent jurisdiction did actually and necessarily determine the standing issue, thus satisfying the second prong of the Yamaha test. Finally, the third prong of the Yamaha test is satisfied because precluding Pannonia from bringing this suit is fair. This case is one in a series of cases in which Pannonia Farms and its president have repeatedly attempted to recover for violations of intellectual property rights. First, in Plunket v. Doyle, No. 99-11006, 2001 WL 175252 (S.D.N.Y. Feb. 22, 2001), Andrea Plunket sued the heirs of the Sir Arthur Conan Doyle Estate for copyright infringement and unfair competition and sought a declaratory judgment as to the rights in question. Id. at *1. That Court dismissed the case, with leave to file an amended complaint, because Plunket failed to join those parties who may have been adversely affected by the Court's ruling on the chain of title. Id. at *7. In 2003, Pannonia Farms filed another lawsuit in the Southern District of New York claiming that a cable company violated intellectual property rights for televising a movie, which featured the Sherlock Holmes and Dr. Watson characters. Pannonia I, 2004 WL 1276842, at *1. Finding that Pannonia Farms did not have standing to sue, that court found "it was wholly unreasonable" for the plaintiff to expect the court to revise a fourteen-year-old state court order. Pannonia I, 2004 WL 1276842, at *7. As is obvious, Pannonia Farms has had every opportunity to pursue and litigate this very issue in court and has lost every time. The decisions in Pannonia I and Pannonia II therefore preclude Pannonia Farms from relitigating the standing issue in this action and the defendants' motions to dismiss based on collateral estoppel are GRANTED. ATTORNEYS' FEES & RULE 11 SANCTIONS Re/Max seeks attorneys' fees pursuant to 17 U.S.C. § 505 and 15 U.S.C. § 1117, as well as Rule 11 Sanctions. For the following reasons, the Court GRANTS IN PART AND DENIES IN PART the motion for attorneys' fees. The decision whether to award attorneys' fees in an action under the Copyright Act is within the sound discretion of the Court. Fogerty v. Fantasy, Inc., 510 U.S. 517, 523-24, 114 S.Ct. 1023, 127 L.Ed.2d 455 (1994). Section 505 provides that; In any civil action under [Title 17 — Copyrights], the court in its discretion may allow the recovery of full costs by or against any party other than the United States or an officer thereof. Except as otherwise provided by this title, *46 the court may also award a reasonable attorney's fee to the prevailing party as part of the costs. 17 U.S.C. § 505. In determining whether such an award is appropriate, the Court may consider the following factors: "frivolousness, motivation, objective unreasonableness (both in the factual and in the legal components of the case) and the need in particular circumstances to advance considerations of compensation and deterrence." Fogerty, 510 U.S. at 534 n. 19, 114 S.Ct. 1023; see also Harrison Music Corp. v. Tesfaye, 293 F.Supp.2d 80, 84 (D.D.C. 2003). After the New York federal court's decision in Pannonia I, Re/Max sent a letter to counsel for Pannonia Farms asking it to withdraw or dismiss the complaint because "its [sic] collaterally estopped from claiming ownership of [the rights in the works of Sir Arthur Conan Doyle]." Re/Max Supp. Mot. to Dismiss Ex. A. Pannonia Farms stated that it was willing to amend its complaint to remove the copyright claims, but insisted that the trademark claims remained. Id. Ex. B. But, the New York federal court held that Pannonia did not "own[] the copyrights, trademarks and related rights in the works of Sir Doyle." Pannonia I, 2004 WL 1276842, at *6. Therefore, it was objectively unreasonable for Pannonia Farms to continue to pursue any of the intellectual property claims after the New York federal court found that it did not have any ownership interests. Accordingly, the Court awards attorneys' fees to Re/Max for its preparation and litigation of the Supplemental Motion to Dismiss Based on Collateral Estoppel. Re/Max also seeks attorneys fees under the Lanham Act, which provides: [w]hen a violation of any right of the registrant of a mark registered in the Patent and Trademark Office, a violation under section 1125(a) or (d) of this title, or a willful violation under section 1125(c) of this title, shall have been established in any civil action arising under this chapter, the plaintiff shall be entitled . . . to recover the costs of this action. . . . The court in exceptional cases may award reasonable attorney fees to the prevailing party. 15 U.S.C. § 1117(a)(3) (emphasis added). Since this Court's decision to dismiss this case is based on plaintiff's lack of standing, a violation under the Lanham Act has not been established and attorneys fees are inappropriate. Finally, Rule 11 provides that "[i]f, after notice and a reasonable opportunity to respond, the court determines that subdivision (b) has been violated, the court may . . . impose an appropriate sanction upon the attorneys, law firms, or parties that have violated subdivision (b) or are responsible for the violation." Fed. R.Civ.P. 11(c). Sanctions may be initiated by a party's motion or on the Court's own initiative. Id. Re/Max includes its motion for Rule 11 sanctions in its supplemental motion to dismiss and motion for attorneys' fees. Re/Max, therefore, did not comply with the requirement in Rule 11 that a motion for Rule 11 sanctions be "made separately from other motions or requests." Id. 11(c)(1)(A). And, while the plaintiff's refusal to withdraw its complaint may constitute sanctionable conduct, the Court declines to impose Rule 11 sanctions sua sponte. ORDER For the reasons set forth above, it is this 21st day of March, 2005 hereby ORDERED that the Defendant Jon Lellenberg's Supplemental Motion to Dismiss Based on Collateral Estoppel [# 24] is GRANTED, and it is further *47 ORDERED that the Defendant Re/Max International, Inc.'s Supplemental Motion to Dismiss Based on Collateral Estoppel and Motion for Attorneys' Fees [# 26, # 27] is GRANTED IN PART AND DENIED IN PART, and it is further ORDERED that Defendant Jon Lellenberg's Motion to Dismiss [# 7] is DENIED as moot, and it is further ORDERED that Defendant Re/Max International, Inc.'s Motion to Dismiss [# 8] is DENIED as moot. SO ORDERED. NOTES [1] Pannonia Farms, Inc. v. USA Cable, No. 03-7841, 2004 WL 1276842 (S.D.N.Y. June 8, 2004) ("Pannonia I"). The same court denied the plaintiff's motion for reconsideration in Pannonia Farms, Inc. v. USA Cable, No. 03-7841, 2004 WL 1794504 (S.D.N.Y. Aug. 10, 2004) ("Pannonia II"). [2] Although Andrea Reynolds (aka Andrea Plunkett) signed the agreement in her individual capacity, the New York federal court found that because she was President of Pannonia Farms at the time of the agreement, Pannonia Farms also assented to the terms of the settlement agreement. Pannonia I, 2004 WL 1276842, at *6. The court held that bringing the action against USA Cable, "a stranger to the Settlement, . . . without joinder of the parties to the Settlement, is not the forum for Pannonia to avoid the Settlement's consequences." Id.
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Norma Yaeger shares her stories with Bill Black as she was the first woman stockbroker permitted to walk on the floor of the New York Stock Exchange in 1962. We discuss how opportunities have opened up for women in the workforce since, and her book "Breaking Down the Walls". Questions Answered: 1.What opportunities do women have today that did not exit in 1962? 2. What traits should every successful woman have. 3. Tips for balancing family and career for working women. 4.What should every woman understand about their financial well-being. Exit Coach Bill Black interviews Top Advisors for Tips, Ideas & Precautions for Business Owners who want to grow and protect their company value and plan for a successful Business Sale or Transfer. Listen daily so you can be well-planned!
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[IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] In the News June 8, 2001 [IMAGE] [IMAGE]Worm launches Microsoft attack [IMAGE]Changing times in tech mecca [IMAGE]Yahoo scores victory in Nazi case [IMAGE]Aggravated consumers pummel PCs [IMAGE]Computer glitch temporarily halts NYSE [IMAGE]MSN U.K. plays with casino Web site [IMAGE] [IMAGE] [IMAGE] [IMAGE] Rumor Mill [IMAGE] [IMAGE] Blacklist backlash ORBS blacklists ISPs Xtra and Actrix--which in turn slap ORBS with a lawsuit--and ultimately shuts down. Read Full Story [IMAGE] [IMAGE] Worm launches Microsoft attack A program created to automatically overload Microsoft's Web and e-mail servers has been discovered on several corporate networks and may have spread further on the Internet, antivirus researchers said Friday. First reported this week, the worm--dubbed DoS.Storm--spreads on Web servers running Microsoft software and is designed to use the infected servers to level an Internet attack against the company. June 8, 2001, 12:40 p.m. PT | Read Full Story [IMAGE] Changing times in tech mecca Computex, the world's third-largest trade show, highlights chip rivalries, handheld computers and the problems facing Taiwan's tech-heavy economy. June 8, 2001, 11:30 a.m. PT | Read Full Story [IMAGE] Yahoo scores victory in Nazi case Yahoo has scored an early-stage legal victory in its ongoing attempt to post material and auction items--including Nazi memorabilia--on its Web site that may be offensive to people in other countries. Last year, a French court ruled that Yahoo must block French citizens' access to auctions of Nazi items on its U.S.-based site or face fines of $14,000 per day. June 8, 2001, 12:20 p.m. PT | Read Full Story [IMAGE] Aggravated consumers pummel PCs A quarter of the 4,200 PC users who participated in an online tech store's survey have confessed to physically attacking their computers at one time or another. "Looking at some of the answers, it's clear that in many cases people were actually frustrated at their own lack of know-how," David Furby, Novatech's managing director, wrote on the site. "Hopefully as technology improves and computers become ever more user-friendly, these attacks will become less frequent." June 8, 2001, 11:10 a.m. PT | Read Full Story [IMAGE] Computer glitch temporarily halts NYSE The New York Stock Exchange, the largest equity market system in the world, halted trading on all stocks Friday morning because of problems with a software upgrade. According to a spokeswoman, trading was set to reopen at 8:15 a.m. PDT, but the exchange missed the deadline. Trading resumed at 8:35 a.m. NYSE Chairman Richard Grasso, appearing on CNBC, had said he was confident the exchange would open on time. June 8, 2001, 8:45 a.m. PT | Read Full Story [IMAGE] MSN U.K. plays with casino Web site Microsoft's U.K. portal has inked a two-year marketing deal to provide advertising and promotions for an online casino, Web-based gambling company Gaming Internet said Friday. Under the agreement, MSN.co.uk is expected in mid-June to begin linking to international gaming site Harrods Casino, a joint venture between Gaming Internet and Harrods Online subsidiary Sporting Resort. MSN.co.uk will also provide banner advertising on its site and a promotional page. June 8, 2001, 12:40 p.m. PT | Read Full Story [IMAGE] [IMAGE] Visit the CNET Research Library, powered by Bitpipe Also from CNET IT Manager Community from Tech Republic Featured Comparison: 50 Most Popular Handhelds Test Your Internet Connection Laid off? Apply for a new tech job Build an Online Photo Album [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] What's next for Napster Napster has cut deals with three major record labels, provided it can protect copyrights. [IMAGE] Watch Video [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] Enterprise IBM reveals new strain of chip power Report: Ax moldy, Cold War tech-export law Commentary: Java's widening gulf E-Business 7-Eleven expands e-financial services Judge snuffs out ban on cigarette sales SAP show to focus on e-business Communications NetZero, Juno to unite in merger HP pulls TV ad after icy response MCI Group fizzles in trading debut Media IM rivals mute on messaging plans State Department behind the Internet times Business 2.0 folds into AOL Time Warner Personal Technology Ex-Lernout CEO won't fight extradition Internet appliances: Down, but not yet out New players in the game market [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] [IMAGE] Investor Dispatch News.Context More CNET Newsletters For prompt service, please include the email address used for your subscription on any correspondence with us. 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The Senate has today passed Labor amendments that will give the Australian Tax Office access to information about big companies’ financial affairs sooner, and improve public transparency. The Common Reporting Standard is an important global agreement for cracking down on multinational tax avoidance. It allows tax authorities to automatically exchange information about the contents of company and individual bank accounts. Until now, multinational companies and wealthy individuals have often been able to avoid paying tax in one country simply by sending their money offshore to another jurisdiction so that tax authorities cannot see it. Under Treasurer Joe Hockey, the Government dragged their feet in signing Australia up to the Common Reporting Standard and refused to join the Early Adopter Group that will begin exchanging information next year. When introducing the bill to implement the standard in Australia, Treasurer Scott Morrison then set a timetable which would have let big companies off the hook in having their accounts reported until the end of 2019. Labor’s amendments have brought forward the reporting date so that the Australian Tax Office can begin exchanging company information sooner. In addition, Labor’s amendments will also ensure the tax office publishes an aggregated report of Australian financial holdings by foreign residents from each individual tax jurisdiction. This will increase public transparency about Australia’s place in global money flows. Tax transparency groups have called for this to ensure Australia is not inadvertently playing a part in tax avoidance schemes originating in neighbouring countries throughout our region. Having criticised Labor in the House of Representatives for our efforts to amend the Common Reporting Standard Bill, the Government saw sense in the Senate and agreed to support these important changes. Just as with last year’s multinational tax bill and their recent changes to foreign investment rules, it takes pressure from Labor to make this Government take tax avoidance seriously. Our campaign to tighten Australia’s tax net and ensure everyone pays their fair share of tax does not end here. Next week I will table a Private Members Bill to increase penalties for companies that do not lodge country-by-country tax reports from $5,400 to $270,000. This will help ensure that companies obey the law, rather than merely choosing to pay the fine. The Coalition might redeem its poor record on multinational taxation by backing that bill, just as they belatedly chose to back Labor’s Common Reporting Standard amendments today. Only Labor is serious about making our tax system fairer, as our long-running battle against multinational tax avoidance shows.
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"Kids, I gotta tell you, I love the day after Thanksgiving." "We already got that "giving thanks" crap out of the way and we get to have leftovers." " Peg, is it ready yet?" " Here it comes!" "You know, Daddy, that was a great idea last night:" "To only eat the cheese so we'd have the crust today." "Yeah." "I'll bet a lot of other stupid families ate their whole pizza last night." "And today they're probably just looking at the old empty cardboard box." "I can't do it." "Dad, I think I speak for us all." "This really bites the big one." "Why can't we have turkey like real people?" "Now, Bud." "It's not like your father is a doctor or a lawyer or a bathroom attendant or a circus geek." "He's just a shoe salesman, doing the best he can." "Okay, Peg, I think we get the message here." "Obviously, this is the fault of the only one who works here." "That would be, let me see:" "Well, goldarn it, it's me." "Well, what the heck, I'll quit." "Then we'll be a-eating, won't we?" "Oh, honey, nobody wants you to quit." "We all appreciate what you do for this family." "Well, we might as well face the facts." "This food thing isn't going to go away." "We've gotta get some money." "There's got to be something here we can sell." " How about Mom's engagement ring?" " Kelly." "Now, that ring is a symbol of our love." "We could never put a price on that." "That's right, honey." "Like they say, "Glass is forever."" " Hey." " Oh, come on, Al." "I had it appraised the day after our wedding." "Remember when you were resting?" "It was a big day for Mommy, honey." "Yeah." "That was the last day of rest for Daddy." "What about Kelly's schoolbooks?" "We could sell these." "Oh, yeah, my English book." "Oh, I ain't got no use for that." "Honey, these schoolbooks are very important to your future." "Oh, who am I kidding?" " Let's see what condition they're in." " Well, let's see." "What do we got here?" "What's this?" "" Detention, detention." "Expulsion."" "Oh, here's something interesting." "" Host a foreign exchange student receive $500 a month expenses."" "That's what we'll do, Peg." "We'll get us one of those $500-a-month foreigners." "I don't know, honey." "We don't have much room." " Where are they gonna sleep?" " Well, what's the garage for?" "I know, I know!" "It's for the car." " We'll move it over to the side." " Yeah, but it's freezing in there, Dad." "Hey, I didn't say we should sleep in the garage." "I wonder when little "Y-vette" will get here." "Kelly." "I believe her name is pronounced "Yvette."" "I was pronouncing it in English." "Oh, man, what a break." "Getting a 17-year-old French babe." "Oh, the times we'll have." "Don't go boinging around the house just yet, toad boy." "Frenchie's all mine." "At last I'll have, like, a sister." "A real girl." "Not just a boy trapped in a pimple's body." "It'll be great." "I can teach her about American guys and she can carry my school supplies." "You know, like my music, my Walkman, my overnight bag my make- up." "The red light bulb that goes over your head." "Oh, you mean like when I get an idea?" "Al, do you think we should've picked Yvette up at the bus station?" "No." "I hate bus stations." "Vagrants, winos." "There's people there who'd cut your throat for a nickel." "I think I see someone." "She's dragging her trunk down the street." "Al, give her a hand." "Hey!" "Over here!" "Boy, it's getting cold out there." "Hello, my name is Yvette." "Hello." "Welcome to our country." "We have so many questions to ask you." "What's your country like?" "How was your trip?" "Where's our money?" "I apologize for "ze animals."" "I'm Bud Bundy, your love interest." "And this is Mom and Dad." "And I'm Kelly." "You'll be going to school with me so if there's a heinie to be kissed around here, it's mine." "Oh, my, you are so attractive." "Are all American girls as beautiful as you?" "In their dreams." "Well, I am so happy to be in Chicago, land of the Cubs and the big wind." " AI." " It wasn't me." "I would love to talk for hours, but I'm cold and tired." " Where will I be sleeping?" " My room is this way." "The left side of the bed is for you." "That's because he wets to the right." "Oh, now, kids." "No, honey, you'll be staying in the guest room next to the car." "Yeah." "Now, if it's a little chilly in there, don't worry about it." "We're going to try to get that garage door down real soon." " Got it, $500." " Give me that." "Well, I've had a long flight, and a long walk from downtown so I'm a little hungry." "Do you think I could have a little bite...?" "And this is the hall where my locker is." "Kelly, we've been at school for hours." "Will we be going in a classroom today?" "Look, do you want to see how it's done in America, or what?" "I'm sorry." "What happens next?" " Well, first we'll meet some boys." " How do we do that?" "Kelly, hi!" "Hi, listen." "Saturday night my parents are out..." "Hey, I was talking to Kelly." "Oh, you are so popular." "Yeah, well, I'm kind of like The Beatles of the 20th century." " Now, do what I did." " Oh, no." "I'm far too shy." "Go ahead." "Maybe you'll get one." "Hi, I'm Hank." "Welcome to Polk High." " What's your name?" " Yvette." "Nice to meet you." "A toast to the French." "It's a foul little country, but they sure do know how to write a check." "Kelly, honey, aren't you gonna eat your dinner?" " I'm not hungry." " Well, let me have that." "Watch out, over there!" "What's wrong, you ask?" "Well, I'm socially dead." "Yesterday's girl." "A Bud." "Why, you ask?" "Okay, well, I'll tell you." "Because the little French poodle that you all love is taking all my action." "Oh, Daddy, what's a washed- up has-been supposed to do?" "Mom, what kind of guys will I wind up with when no one else wants me?" "Oh, no." "Come on, Kel." "So Yvette makes you look like day-old eggs." "So what?" "There's still hope for you." "Why, you could be a coat rack, an ashtray, a speed bump." "Listen to your brother." " Door." " Get the door." "Sure, I have no life." "I'll get it." "Maybe it's someone from the Future Geeks of America wanting me to join." "Yep." "It's the founders." "Hi, Kelly." "Peggy, may we talk to you for a second?" " Let me have that." " Give me that!" "Peggy, we don't know how to tell you this..." "Well, I do, Steve." "Peggy, Al has a young girl living in your garage." "We saw her last night burning leaves for warmth in your driveway." "The pig didn't even have the decency to set her up in an apartment." "Well, it's not that easy, Marcie." "You got to buy money orders under a different name to pay the rent." "Then..." "Where do you keep the extra key?" "Just try to get a phone with an alias these days." "Not that I've ever given it much thought." "Well, anyway, here are some pictures of her we took and the name of a good divorce attorney." "I'm sorry we had to be the ones to tell you this." "Look, I know all about it." "She's just a foreign exchange student that's living here." "And other than having to honk when we wanna get out of the garage, she's..." "She's really been no problem at all." "Yeah." "No problem for anyone but little me." "What's the matter, Kelly?" "Oh, it's that Yvette is dating all her boyfriends and Kelly has the social life of a barn owl." "Kelly's a little depressed." "Could you handle this?" "We're eating." "Oh, now, Kelly." "You mustn't worry over this." "You may find this hard to believe but I myself wasn't popular in school." "The hell you say." "No, it's true." "I couldn't get a date with a cool guy no matter how much I put out." "I mean tried." "So I finally started dating a nerd." " You dated a nerd?" " Yes." "His name was..." "Well, his name isn't important." "My friends couldn't believe I had sunk so low." "Boy, did they laugh when I let him take me to the homecoming dance." "Wait a second." " I took you to the homecoming dance." " That's right." "You did." "Anyway, we went on dating and I endured the laughter and the ridicule and I came to marry..." "Well, his name isn't important." "The point is, yesterday's nerd can grow up to be a wonderful and giving man." "So if all you can get is a nerd, I say try one." "I did." "Hey." "Wait a minute." "I know who you're talking about." "And let me tell you something, you think you heard laughter?" "Well, when I was dating you, I had a few Milk-Bones slipped into my pocket." "I was pretty!" "My mother told me so." "Compared to your mother, you were." " Oh, so now you don't like my mother." " What's not to like?" "A 60-year-old woman who played the drums." " Nerd." " Geek girl." "So that's my future." "Well, that and 40 pounds." "Never." "I will never sink so low as to date a nerd." "I may not have much, but at least I have my pride." "It's been an illuminating evening, Miss Bundy." "I'm sorry I spilled my prune juice on your blouse." "Yeah, and I'm sorry I punched you in the pelvis." "Perhaps I can have the pleasure of your company again next Friday." "The museum is having a quite interesting exhibit on the ever- changing mollusk." "Well, only if you wear your green pencil pouch." "Turns them all on." "Well, I've had a great time, guys, but I got to run." "Kelly, you know what would make this the perfect evening?" " Oh, what, Myron?" " Lf Yvette would kiss me good night." "You just blew a good thing, baby." "Oh, my, I'm so tired." "Thank goodness you taught me how to sleep at school." "So how was your date with Le Grand Geek?" "Well, we sat around with his parents and they showed me slides of their vacation to the Ticonderoga pencil factory." "You know, the number 2 pencil is the backbone of the industry." " Oh, that's very fascinating." " No, it isn't." "It's the prattle of the dead." "Yvette, we need to discuss..." "Oh, I would love to talk to my little American sister but my next date will be here any moment." "He told me I could wear your leather mini." "You don't mind, do you?" "I mean, you are in for the evening, no?" "Thanks." "Hi, Grandma." "Sorry, Kel." "Must've been the way the light hit your crow's feet." "Bud, what are you doing?" "I'm building a home entertainment centre." "Bud, I need your help." "I'm desperate." "No, you're not." "Desperate still implies hope." "You wouldn't want to help me get rid of Yvette, would you?" "Well, I can't take this anymore." "I'm gonna have to do it myself." "Kelly, I say this with all sincerity." "If you truly, truly want to get rid of her I'll kill you." "I really will." "This is not a joke." "Dead." "Bud, what are you doing?" "I'm..." "I'm giving you some ventilation." "You know, so the heat can get through." "Oh, it's all right, Bud." "I don't mind if you peep." "Yeah, I'll give that up." "The day they pry her from my cold, dead hand." " What a cute little fellow." " He's toilet film." "Au rev oir." "Well, excuse me, young lady but where are you think you're going?" " On a date." " Oh, no you're not." "I got a call from the principal today." "And it seems you're failing all your subjects." " We just can't have that." " I'm failing too." "Kelly, please, we're talking to Yvette." "He didn't mean that, dear." "You have to study too." "I suppose." "But if she fails, she has to go back home." " And we're out 500 bucks a month." " We're responsible for your education." "You know, and if there's one thing we are, it's responsible parents." " Stop that, Al." " I can't help it." "I'm giddy." "Must be from all this darn eating." "Come here." "Come here." "Well, I guess we better study." "I'd love to, but I've got to go dust off my accordion for school tomorrow." "I've got my eye on the big, fat tuba player." "Oh, please, Kelly, you have to help me." "I'll beg someone to go out with you." "If I fail, I'll have to go back to France and I'll have to give up all your boyfriends." "Listen, Yvette there's no point in us both staying home." "Go out." "Have a good time." "I'll study, and when we take our test you can copy off me." "Oh, you would do that for me?" "What are little American sisters for?" "Okay, who wants seconds on crust?" "I can't believe it." "Yvette flunked every subject." "She even flunked French." "She must be the stupidest girl in the world." " Well, I'm the stupidest girl in America." " I know you are, pumpkin but we're talking about something important now." "Honey, you're important too." "Just not as important as 500 bucks." "Oh, Al, now they'll never give us another exchange student." "Yeah, I never got to use my holes." "Well, what about me?" "I lost a sister." "I'm hurting too." "My dates are here." ""Au verar"!"
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Fathammer Fathammer was a video game publisher and developer based in Finland. They have developed game cell phones, the Tapwave Zodiac, and also the Gizmondo. Fathammer was acquired by Telcogames in June 2006, and X-Forge game development environment developed by Fathammer was sold to Acrodea. Notable games Chronicles of Narnia Hockey Rage 2005 Tomb Raider: Legend Toy Golf References Category:Video game development companies Category:Video game publishers Category:Video game companies of Finland
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At the University of Minnesota, just a slap shot away from Mariucci Arena and Williams Arena, there's a team that operates in the shadows of the nation's No. 1-ranked men's hockey team and two basketball programs riding roller-coaster seasons. Gophers women's hockey coach Brad Frost has called his team "the best-kept secret in town." They're rarely on TV, they have trouble filling seats at Ridder Arena, and their star players can float anonymously through campus. But now, a red-hot season and an assault on the national record book have fueled talk that this could be the best team in women's hockey history. During its NCAA-record 34-game winning streak, which began last February, Minnesota has trailed just twice. The first deficit lasted 39 seconds. The second one came Jan. 12 against North Dakota. That time -- gasp! -- it took 27 minutes for the Gophers to even the score, and it was still tied 1-1 after two periods. "Honestly, we went into our coaches room after that period and were like, 'This is fantastic,'" Frost said. "We needed it. Last year, the season was full of adversity. And this year, we just haven't faced a ton of it." The Gophers burst from their locker room and scored five third-period goals against UND, including two by the nation's leading scorer, Amanda Kessel. They haven't trailed since. After winning their final eight games last year to claim their first NCAA title since 2005, the Gophers are 26-0 heading into Friday night's game against Minnesota Duluth at Ridder Arena. Minnesota's home rink, which seats 3,400, will be the site of this year's WCHA's Final Face-off, along with the Frozen Four. So the Gophers could wind up playing all but four of their remaining games at home, and it's not hard to imagine them running the table. It's happened in several other college sports. The Baylor women's basketball team went 40-0 last season. The Cornell men's hockey team skated to a 29-0 finish in 1970. But nobody has done it in women's hockey, which began crowning an NCAA champion in 2001. "That would definitely be something special to go undefeated the whole year," Gophers goaltender Noora Raty said. "But if we lose one or two games and still win the national championship, it would be a perfect season for us." One game at a time Now in his 13th season with the program, and sixth as head coach, Frost said he learned long ago not to talk about national championships during a season. The focus, he said, always should be the next game. "I think their staff's doing a great job," said Harvard coach Katey Stone, who will coach Team USA at the 2014 Olympics. "They're attracting some tremendous talent, they're developing it, and they have some big-time players." Stone's Harvard squad, which is 17-2-1, is among the teams that hope to dethrone Minnesota in the NCAA tourney. One reason the Gophers shouldn't be overconfident is they haven't faced a team this year that's currently ranked higher than eighth. After Minnesota, the rest of top seven are six teams from the East -- Boston College, Harvard, Boston University, Cornell, Clarkson and Mercyhurst. GOPHERS WOMEN VS. MINN. DULUTH If the Gophers do indeed run the table, could they go down as the best women's college hockey team of all time? "It's a fair question," said Natalie Darwitz, a three-time Olympian who was part of NCAA title teams for the Gophers in 2004 and 2005. "If you're a numbers person, the numbers are there and speak for themselves. I do think it's hard to compare where they're at now versus past teams." Either way, Darwitz said, what the Gophers are doing is great for the sport. "The frustrating part," she said, "is it took a 34-game winning streak to start people talking about it." The Big Ten Network will broadcast Saturday afternoon's game against UMD, but that's Minnesota's only scheduled telecast this season. Last year's NCAA title game wasn't televised and this year's finale, on March 24, won't be either. Still, Frost has been pleased with his team's increased coverage of late. "I just don't want them to get complacent and think that they've arrived just because they've had a great first half of the season," said Frost, whose team has eight regular-season games left. "I've seen a lot of [Gophers] teams play really well in the first half and kind of fade in the second half." This team is showing no signs of fading. In fact, the spotlight is starting to shine bright. Attempting to reduce wear on its players, the NBA opened its season two weeks earlier this year, a change that reduced the number of back-to-back games and ensured teams now won't play four games in five nights.
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Q: how to get single string property of LongListSelector selectedItem i have this LongListSelector bound to observerableCollection <DataTemplate x:Key="ucItems" > <Grid Margin="0,0,0,17"> <TextBlock Text="{Binding Title}" TextWrapping="Wrap" Style="{StaticResource MyBigBoldPhoneTextStyle}" /> </Grid> </DataTemplate> and <toolkit:LongListSelector x:Name="ucLongList" IsFlatList="True" ItemsSource="{Binding UcItem}" ItemTemplate="{StaticResource ucItems}" ListHeaderTemplate="{StaticResource ucHeader}" SelectionChanged="ListBox_SelectionChanged" /> UcItem has 3 property which are: Title, ImageUri, Link I need to get the selected-ucItem-Link property to pass it to other methods. how can i do that? Im new to LongListSelector and i used to get a selected property from SelectedIndex from listbox. And there is no selectedIndex in LongListSelector so i have to use SelectedItem to get the single property on it. please help thanks. A: Here's the xaml for DateTemplate <DataTemplate x:Key="ucItems" > <Grid Margin="0,0,0,17"> <TextBlock Text="{Binding Title}" TextWrapping="Wrap" Tag="{Binding}" Style="{StaticResource MyBigBoldPhoneTextStyle}" /> </Grid> </DataTemplate> Now for codebehind. When you are looping through the selecteditems var tbSender = (TextBlock)sender; var theReference = (UcItem)tbSender.Tag; Messagebox.Show(theReference.Link); So that way the Tag attribute will reference to the instance of UcItem.
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Speak No Evil (film) Speak No Evil is a 2013 American independent horror film written and directed by Roze and produced by Gas Mask Films and financed by MINDPLATE.tv. It stars Gabrielle Stone, Carl Jensen, Mario Guzman, Olivia Cavender, Annalise Cavender, Elisabeth Cavender, and Sean Wesley. The film was scored by Jason Camiolo. Plot Speak No Evil is the story of Anna (Gabrielle Stone), a young single mother and her daughter who are trying to survive after the rest of the town's children have been possessed by demons. The movie begins with the disappearance of Joey Girl (Olivia Cavender) from a small desert town. Her mother, Anna, calls the police, but isn't taken seriously until all of the children in the town disappear overnight. When the children, including Joey Girl, return, they appear changed; parents in the town turn against their children. Anna strives to save her daughter while helping the other youngsters. Cast Gabrielle Stone as Anna Olivia Cavender as Joey Girl Carl Jensen as Craighton Mario Guzma as Dale Greg Bronson as Noel Annalise Cavender as Becca Elisabeth Cavender as Jessabelle Sylvie Cohen as Miss Crowley Sean Wesley as Adramelech Production Gas Mask Films, a Tempe-based production company owned by Roze and his wife, Candace Rose, began production on Speak No Evil in October 2012. Production lasted sixteen days and was completed on October 29, 2012,. Script and Development Speak No Evil was written by Roze and Candace Rose as an art-house horror film about the sun god Adramelech. Casting Speak No Evil was produced in Arizona and has a cast largely made up of Arizona talent, including the Cavender sisters. Gabrielle Stone, an up-and-coming actress and daughter of noted actress Dee Wallace is one exception. Filming Speak No Evil was shot on the Red Epic camera in 16 days in Apache Junction in Arizona. It was largely crewed by students and alumni of the Film School at Scottsdale Community College. Release Speak No Evil began its limited theatrical release when it premiered at the Tempe Valley Art, which is part of the Harkins Theatre chain in Tempe, Arizona on May 24, 2013. Awards Speak No Evil won Best Horror Feature at the Jerome Film Festival in Jerome, Arizona. Reception The filmed garnered mixed reviews from a number of film review websites. References Category:2013 films Category:American horror films Category:American independent films Category:American films
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“They said: Come, let us make a city and a tower, the top whereof may reach to heaven; and let us make our name famous before we be scattered abroad into all lands.” The work was soon fairly under way; “and they had brick instead of stones, and slime (asphalt) instead of mortar.” But God confounded their tongue, so that they did not understand one another's speech, and thus scattered them from that place into all lands, and they ceased to build the city. Genesis 11:1-9. Since the fall of the Tower of Babel, finding methods of communicating with different languages and their associated writing systems has been a challenge. With the onset of worldwide globalization, overcoming this challenge has become paramount. However, there are complex cultural differences between nations that have prevented a fully integrated global society. In the computer industry, these differences cause problems with international cooperation due to the tethers of multi-language display and interchange. One step toward meeting the challenge of a multi-national computing industry was the Unicode Consortium formed in 1988, which developed a global character identification standard. The goal of the consortium was to develop a standard that allows a unique identification of characters for every language. The consortium developed the Unicode Standard, now in version 2.1, available from Addison-Wesley Developers Press 1997, (available at http://www.unicode.org). Unfortunately, being able to print and display a character from a choice of many languages is only a small step toward meeting the international challenge. An issue of equal and oft times more importance is the layout of script, the characteristics of fonts, and the general requirements of text that make text readable. However, typefaces and script forms of current languages are different, eclectic and do not follow the same rules. For example, a typical English font, Times New Roman, follows a typographical formula that is uniquely Roman based wherein line height is typically set to be 120% of the size of the font in points. Terminology is based on Roman characters. The concepts of Roman type include a base line, a cap height, an ascender height, a descender height and line height. Written languages do not follow the same rules for font characteristics such as a default line length or typeface. Rather, each language and script is culturally derived from a different basis. For example, some Asian scripts use glyphs that are pictorially derived and other Asian scripts read from right to left and are symbolically derived. Even within the same language, scripts and fonts do not follow a predetermined characteristic formula. Finding a formula for determining default font characteristics seems an impossible task. Rather than finding a formula appropriate for all languages, graphic designers have relied on visually altering line length, typeface and line heights, altering each script such that a rendering is pleasing to the eye and meets readability requirements known to the graphic designer. Currently, there is no solution for determining font characteristics that applies to all known scripts. Every script is culturally derived and has a different basis and completely different concepts. Even if a formula worked for a particular script in a particular language within each script, there is not a linear relationship to many characteristics of the script. For example, any changes to font size or line length in the same script require changes in line height that take into account readability. Graphic designers typically visually alter line length, typeface, and line height. Longer lines of type require more line height for readability. Also, the size of a font is relevant to line height, but a larger font does not require the same line height as a smaller font. Because there is no linear or obvious relationship between line height, line length and changing font sizes, many computer applications require manual changes. Further complicating the layout issues, graphic designers do not know the rendering device of type due to the plethora of rendering computing machines. A typed page designed for a web page, for example, can be rendered on any size screen, leaving the optimum reading sizes for line length, line height and font size as an unknown. What is needed is a method for automatically determining those characteristics that currently require a graphics designer. An automatic method and system that can compute readability parameters, such as line height, font size and line length is needed so that text can be rendered on any display, in any language and in any size without manual adjustment.
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Mac OS X 10.5.5 has been released and can be downloaded through software updater or Apple’s website. 10.5.5 is fairly extensive and the full release notes can be found here. While this update can be considered ‘safe’, its good to follow guides such this one to prevent AppleIntelCPUPowerManagement.kext from breaking your install. AMD users can use the AMD Software Patcher for a safe installation. 10.5.5 Combo Update (601 MB)
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William Reid Dick Sir William Reid Dick (1879–1961) was a Scottish sculptor known for his innovative stylisation of form in his monument sculptures and simplicity in his portraits. He became an Associate of the Royal Academy in 1921, and a Royal Academician in 1928. Dick served as president of the Royal Society of British Sculptors from 1933 to 1938. He was knighted by King George V in 1935. He was Sculptor in Ordinary for Scotland to King George VI from 1938 until his death. Early life Born in Glasgow, Dick was apprenticed to a stonemason at the age of twelve and during the next five years he learned to carve stone at work, and at night took drawing and modelling classes. He completed his apprenticeship in 1896. In 1907, he graduated from the Glasgow School of Art and accepted a teaching position at Bellshill Academy in Lanarkshire. By 1908 he was living in London and exhibiting in galleries and took evening classes at South London Technical School of Art whilst working for the sculptor Edwin Whitney-Smith. War service In September 1914 with his reputation as a sculptor growing, Reid Dick joined the Territorial Army and from 1915 to 1919 served with the Royal Engineers in both France and Palestine. Reid Dick's Service Record has fortunately been preserved as part of the "Burnt Records" series at the National Archives in Kew and can be found under reference WO 363/MIS-SORTS 34/52. From this file we learn that when Reid Dick signed up on 1 September 1914 he joined the 5th London Field Ambulance section of the Royal Army Medical Corps with regimental number 1752. He was 34 years and 4 months of age and gave his address as 1 St John's Wood Studios, Queens Terrace, St John's Wood. His wife Catherine was shown as "next of kin". Reid Dick subsequently transferred to the 3rd Army Field Survey Co, part of the Royal Engineers and then the 7th Field Survey Co. He was in this period allocated regimental numbers 536331 and 244831. He was described as a photographer with the 7th Field Survey Co. His Army Service record shows his profession as "sculptor". We can also view his Medal Index Card under reference WO 372/6-52934/2976 [1]. We see that he was awarded the 1915 Star and the British and Victory Medals. Interesting to note that his medals were engraved with the Royal Army Medical Corps shown as his corps rather than the Royal Engineers. Whilst in the trenches Reid Dick did many small carvings from chalk. A story is told that a padre, touring the trenches, saw Reid Dick at work, and by way of a compliment told Reid Dick that he might well consider taking up carving as a hobby. As we now know William Dick Reid was to become a foremost sculptors. Life after military service Dick did indeed fulfil the padre's prophecy and produced several superb works. Reid Dick designed several war memorials and received a major commission for the Kitchener Memorial Chapel (1922–25) in St Paul's Cathedral, London. The focal point of his design for the chapel was a Pièta, which won a gold medal at the Paris International Exhibition of Modern Decorative and Industrial Arts in 1925. This work secured his reputation and election to the Royal Academy. Throughout his career, Reid Dick worked tirelessly both in the studio and serving on numerous committees, among these the Royal Fine Art Commission (1928–42), the Royal Mint Advisory Committee (1936–53), and the Board of Trustees of the Tate Gallery (1934–41). In addition he was President of the Royal Society of British Sculptors between 1933–37. His archives are held by the Tate Gallery and he was buried in St. Paul's Cathedral, London. Main works Images Rickmansworth Lion and Eagle sculptures Images Bushey War Memorial {| class="wikitable sortable" |- ! scope="col" style="width:100px;"| Name ! scope="col" style="width:100px;"| Location ! scope="col" style="width:600px;"| Comments ! scope="col" style="width:150px;"| Image |- |Chapel of All Souls (Kitchener Memorial Chapel) |St Paul's Cathedral City of London |Reid Dick worked on the Kitchener Memorial in what is now known as The Chapel of All Souls in St Paul's Cathedral. After Kitchener's death when the "Hampshire" was sunk in June 1916, a "Kitchener Memorial Committee" was formed to choose and organise a fitting tribute to his life and achievements and the Kitchener Memorial Chapel was selected. The memorial includes a Pieta and the figures of the Warrior Saints St Michael and St George and a recumbent Lord Kitchener in white marble, all the work of Reid Dick. At Kitchener's head is a tablet on the wall which reads and next to the effigy itself is another inscription Image shown right courtesy Tony Worrall and that in gallery below courtesy Alexander Gordon. Reid Dick also worked on the Queen Alexandra's Imperial Nursing Service Memorial Tablet in the Kitchener Memorial Chapel | |- |Horlicks Limited War Memorial |Slough Berkshire |This memorial is located in the grounds of the Horlick's factory in Stoke Poges Lane, Slough. Reid Dick's sculpture for this memorial is a bronze figure of a woman in an attitude of grief. The memorial is dedicated to the 7 employees of Horlicks who gave their lives in the First World War. | |- |The Royal Air Force Memorial |Westminster Greater London |This memorial is located on the Victoria Embankment and comprises a stone column surmounted by a large globe on which Reid Dick has sculpted a gilt eagle with wings upstretched and facing towards the Thames. The memorial's inscription reads This memorial was unveiled in 1923 by the Prince of Wales. His speech included the prophetic description of the RAF as "our cloud armies of the future". The Royal Air Force Memorial was designed by the architect Sir Reginald Bloomfield. | |- |The Angus Watson and Co.Ltd War Memorial |Newcastle upon Tyne Tyne and Wear |Reid Dick carried out the sculptural work on the memorial to the employees of Angus Watson and Co Ltd who gave their lives in the First World War. | |- |Sculpture of Franklin Delano Roosevelt |Grosvenor Square Greater London |Reid Dick was commissioned to sculpt this statue of Franklin Delano Roosevelt. | |- |Statue of George V |Westminster London |This statue stands opposite the Houses of Parliament and it was unveiled by George VI on 22 October 1947. File WORK 20/279 at The National Archives in Kew covers the appointment of Reid Dick and the architect Sir Giles Gilbert Scott to be responsible for this memorial and other files WORK 20/201, WORK 20/202, WORK 20/203 and WORK 20/278 all give background information on the work. The completion of the scheme was delayed by the outbreak of war in 1939. The statue was stored during the war in the quarry at Portland and returned to London in 1946. The statue was unveiled in 1947. | |- |Sculpture Lady Godiva |Coventry |Reid Dick was the sculptor of this work in Coventry. On the plinth below the statue are written some words from Tennyson's poem "Lady Godiva" {{Quotation|"Then she rode back, clothed on with chastity. She took the tax away and built herself an everlasting name" inscription|}} | |- |Sculpture Controlled Energy| |Reid Dick created two sculptures for Unilever House. They are positioned at each end of the building's facade and each depict a large shire horse being reined back. It is as though the strength of the two horses would pull the building apart but for the effort of those pulling them back. | |- |The Arras Memorial |Arras |The National Archives at Kew have several files on this memorial. File AIR 1/677/21/13/1891 contains a draft of the Introduction to the Register of the Imperial War Graves Commission (now the Commonwealth War Graves Commission) written by their Director of Records, Major H.F. Chettle. Chettle's covering letter is dated 18 March 1930. Reid Dick sculpted the globe on top of the Arras Flying Services Memorial which is to be found at the Arras Cemetery in Northern France along with the Arras Memorial. A photograph of this memorial is shown below. Reid Dick carved both the badges on the memorial and the great globe, which is 4-foot 6 inches in diameter and weighs almost three tons. The memorial consists of an obelisk with a globe forming a finial on the top. The badges are those of the Royal Flying Corps, Royal Air Force, Royal Naval Air Service, and the combined badges of Canada, Australia, New Zealand and South Africa. The two memorials and cemetery, the work of Sir Edwin Lutyens, are situated in the western part of Arras. The Arras Memorial commemorates almost 35,000 servicemen from the United Kingdom, South Africa and New Zealand who died in the Arras sector between the spring of 1916 and August 1918, the eve of the so-called "Advance to Victory" and who have no known grave. The Arras Flying Services Memorial commemorates nearly 1,000 airmen of the Royal Naval Air Service, the Royal Flying Corps and the Royal Air Force either by attachment from other arms of the forces of the Commonwealth or by original enlistment, who were killed on the Western Front and who also have no known grave. | |- |The Menin Gate Memorial |Ypres Belgium |Reid Dick sculpted the decorative features which adorn the Menin Gate at Ypres, including the lion at the very top. The Menin Gate marks the start of one of the main roads leading from Ypres (Ieper) to the Front Line; the infamous "Menin Road". The gate combines a classical victory arch and mausoleum. Inside and outside are carved the names of 54,896 officers and men of the Commonwealth forces who died in the Ypres salient and have no known grave. The Menin Gate was not in fact big enough to record all the names so was limited to those who died from the outbreak of war to 15 August 1917. The names of the further 34,888 men who died from 16 August 1917 to the end of the war and again have no known grave are recorded on the Tyne Cot Memorial. | |- |Memorial to David Livingstone |Victoria Falls Zimbabwe |Reid Dick was the sculptor of the memorial to David Livingstone. | |- |Memorial to Lord Levershulme |Port Sunlight Merseyside |This Reid Dick sculpture stands outside the Lady Lever Art Gallery at Port Sunlight. Reid Dick's figures at the base of the obelisk represent "Industry", "Charity", "Education" and "Art". The figure on the top of the obelisk, looking to the sky with outstretched arms represents "Inspiration". This memorial was completed in 1930 and honours William Hesketh, the first Viscount Leverhulme who founded Lever Brothers Limited. | |- |} Other work Reid Dick was also the sculptor of- Bas-reliefs for Selfridges store in Oxford Street, London. Figures for St Andrew's House in Edinburgh. The bronze Herald for the Reuters Building in Fleet Street, London. A figure above the entrance to Adelaide House, London Bridge. The figure is in drapes and holds an orb with a bronze astrological band. The Tate Gallery has a bronze mask of a man entitled Androdus by Reid Dick, and the National Portrait Gallery has a Reid Dick bust of Lord Duveen. Statue of Sir John Soane. North wall of the Bank of England. Threadneedle Street, London EC2 Harry Dwight Ripley Monument. St. Marylebone Cemetery and Crematorium. Photographs of statues References Further reading Wardleworth, Dennis (2013). William Reid Dick, Sculptor''. Farnham: Ashgate. . External links Photograph of Sir William, 1933 / Link to info on Workington War memorial, designed by Dick and executed by sculptor Alexander Carrick / Link to info on Saint Andrew's House, Edinburgh, sculpture designed by Dick, executed by Alexander Carrick CAMERA INTERVIEWS – MR WILLIAM REID DICK A.R.A. R.B.S. THE SCULPTOR/ Newsreel film from 30 August 1930. Includes closeup of Dick and video of him sculpting. COVENTRY'S LADY RIDES AGAIN/ Video newsreel from 27 October 1949. Includes footage of Dick's statue of Lady Godiva in Coventry. The collection booth for the fund to erect a memorial of late American President Franklin Delano Roosevelt in Grosvenor Square, London/ 21 November 1946. Various shots of sculptor Sir William Reid Dick with the statue of Roosevelt which he is modelling. Dick at work on his model of Franklin D. Roosevelt, late President of the United States of America./ Unused / unissued material – dates and locations unclear or unknown. Category:1879 births Category:1961 deaths Category:People from Glasgow Category:Alumni of the Glasgow School of Art Category:Burials at St Paul's Cathedral Category:Royal Academicians Category:Scottish knights Category:Scottish schoolteachers Category:Scottish sculptors Category:Scottish male sculptors Category:20th-century British sculptors Category:British male sculptors Category:Members of the Athenaeum Club, London
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There is a major anti-golden rice smear and disinformation campaign underway, spearheaded by Greenpeace with other anti-GMO activists on board. They themselves consider golden rice to be a “Trojan horse” for GM technology in general, so they essentially admit that their motivation is to oppose GM technology, even if that means opposing a technology that can save the sight and lives of poor children. Golden rice is a genetically modified rice variety with enhanced production of beta carotene, the pro-vitamin of Vitamin A. The name derives from its golden color, provided by the beta carotene, the same thing that makes carrots orange. Carrots, by the way, were originally white and were modified through breeding to produce beta carotene, which was a very successful biofortified campaign in Europe that effectively combated vitamin A deficiency. In response to my post from last week on biofortified GM crops, one commenter did a large “cut and paste” into the comments (generally considered a comment etiquette no-no, but I let it through because the topic is so important) with essentially the full anti-golden rice propaganda. The commenter seemed to think this constituted a “convincing” argument. Let’s see. *GR IS STILL NOT READY While there have been long delays in the development of GR since it was “invented” in 2000 (1), this has not been due to the activities of anti-GMO activists, but to basic R&D problems. This is confirmed in a statement by the International Rice Research Institute, the main body working on the GR project (2). According to the Institute, the time frame for developing a new product is about 13 years, and GR is “still under development and evaluation”. In September 2013 the IRRI expected GR to take another two years before it was ready. While this point is essentially correct, it is not an argument against the adoption of golden rice. Golden rice (GR) development began in the 1980s. By 2000 the first GR variety was ready, but it produced too little beta carotene to be effective. GR2, using different genes, was ready by 2005 and contained 23 times as much beta carotene as GR 1. This is enough to effectively combat vitamin A deficiency in cultures that consume rice as their primary staple. So why has GR2 not been implemented 10 years later? This is a complex question, but after reading multiple sources it does seem that the primary reason is that further development is necessary. GR2 was developed from an American rice strain, and is not well adapted to the Asian countries that can most benefit from it. What is happening now is that GR2 is being bred with local varieties that are locally adapted (a process called introgression). The goal is to produce a strain with the beta carotene but also with local traits so that is can match existing cultivars in yield and disease resistance. This will be necessary for widespread acceptance by farmers. This process is time consuming, partly because there are multiple strains of GR2 (representing different locations in which the new genes were inserted), and researchers don’t know which one will make the best cross with the local rice varieties. This is why field testing is so important. But the story is not just that the scientific process of development takes time. Vandalizing of field trials in the Philippines, motivated by anti-GMO sentiments, has caused a delay in the research. Some also argue that the regulatory burden in many countries is excessive, and is motivated by public opposition to GM. This is a good example of the circular nature of many anti-GMO arguments – anti-GMO activism is slowing the development process for new GM varieties, which is then criticized as being slow. In any case, by all accounts we are in the final stages of developing commercially viable strains of GR2 for Asian markets where they are most needed. *GR IS NOT NEEDED GR is an expensive and unproven ‘solution’ to a problem for which better solutions exist. It has swallowed millions in development money and yet is still not ready. In contrast, World Health Organisation programs to combat vitamin A deficiency are cheap, already available – and proven to work. They focus on methods such as educating people to grow green leafy vegetables in kitchen gardens, encouraging breastfeeding of babies, and giving supplements and fortified foods when necessary.(3) Research by Dr Vandana Shiva’s organization Navdanya in India has calculated that green leafy vegetables are up to 3500% richer in beta-carotene than GR.(4) These programs only need modest funding to roll out more widely. They have the additional advantage of simultaneously treating other nutritional deficiencies, as these do not occur in isolation. For example, beta-carotene can only be absorbed by the body if the person eats enough fat. Will GR proponents give out dietary fat with the GR to those who need it? This is an absurd and factually challenged version of the Nirvana fallacy. Sure – if we fixed the problems of poverty, food distribution, and poor education we would solve malnutrition in general. Of course we should be working toward these broader goals, but they are obviously not going to be fixed any time soon (even if every dime spent on GR development were instead devoted to these underlying problems). GR is also not expensive. It’s hard to come up with a single figure, but at the low end estimates are that $2.6 million has been spent on development so far. One study estimated that the total cost of bringing GR to market in India would be $21-$28 million for the next 30 years. This is less than $1 million per year, and most of those costs are for promotion and marketing. By all accounts GR would be a highly cost effective solution to vitamin A deficiency, even more cost effective than the alternatives promoted by anti-GMO activists. Of course, we should continue to pursue other solutions as well, such as supplementation and introducing more crop varieties to local farmers. These efforts are under way, and they have an effect, it’s just not enough. These objections sound very similar to those by anti-fluoridationists – we don’t need fluoride in the water because brushing with toothpaste and other dental hygiene interventions are effective. This is the same fallacy – universal public health measures have the advantage of being universal and automatic. Historically they are therefore much more effective. They are particularly effective for the target populations, such as the poor. Other problems with GR include: 1. Hidden Information on GR’s Genetic Makeup There has been no adequate characterisation of GR in the peer-reviewed literature (5). Where there is secrecy, there is mistrust. No information is hidden. GR development programs are open source. Here is a detailed description of the metabolic pathways altered in GR. The genes inserted and their locations are known. This is simply a false accusation. 2. Breeding Problems The early varieties of Golden Rice were GR1 and GR2 — both bred from Japonica rice varieties because of severe difficulties with breeding from Indica varieties. In the areas which are being initially targeted – India, Sri Lanka, Bangladesh, Philippines – the vast majority of the population eats Indica, not Japonica varieties. Testing of a GR Indica variety did not start until 2010 and outdoor trials appear to be confined to the Philippines. There is still no published data available as to the stability, uniformity, yields or beta-carotene levels of either the older or newer versions of GR. There are no breeding “problems” with GR. The researchers used the rice varieties that are commonly used in research, and are therefore well understood, and now are crossing the GR varieties with locally adapted varieties. Field trials were initially in the US, because of regulatory red tape elsewhere, and now are taking place in the Philippines, which is more appropriate. Essentially the argument here is that – science is taking time, and regulatory hurdles are slowing the process. None of this has anything to do with the safety, effectiveness, and cost effectiveness of GR. 3. Beta-carotene Persistence No one knows how much beta-carotene will remain in GR over time when stored in normal domestic conditions. When some GR1 was sent in 2001 to scientists in Germany, they found that the level of beta-carotene was less than 1% of what it should have been. After cooking the level declined further, by 50%. This finding set back the project by many years. Persistence of beta carotene over time is certainly an issue that needs to be monitored. However, researchers at the International Rice Research Institute have found that the beta carotene levels remain high in rice stored for three months. There is no reason to think they will drop off dramatically after that. Like most of the other objections, this is not a known issue with GR. Opponents are simply raising every possible thing that could theoretically go wrong with a new technology as if it is a deal-breaker. If this becomes an issue, then scientists will address it. Right now it is not known to be a problem. 4. Bioavailability No one knows how “bioavailable” the beta-carotene in GR will prove. Only two published human feeding studies have been conducted to test this – a controversial child-feeding study published in 2012 and an earlier feeding study involving adults, published in 2009 (see point 7 below). Both these “proof of principle” studies fail to give information on whether GR would work in a real-life situation. For example, the GR samples were stored at -80 degrees C and -70 degrees C respectively, prior to their use in the trials. This was to delay any decline in beta-carotene levels. The studies gave no information as to the usefulness of GR in real domestic situations and in a typical diet. Also, the adult feeding study was designed to maximise the absorption of beta-carotene through the addition of 10% butter to the test diet – an unrealistic scenario with respect to the poor people of Asia. There are currently two published studies looking at bioavailability of vitamin A from GR. The first was a test in 5 healthy adults and showed good absorption. The second study was in 68 children aged 6-8 and compared GR to spinach to oil-based vitamin A capsules. They fount that the GR was as effective as the supplements, and more effective than spinach at increasing vitamin A levels. While these studies are limited and preliminary, they do indicate great bioavailability for vitamin A from GR. There is also no reason to suspect otherwise. The objections above are not convincing. The child study, the larger and more definitive of the two, did involve real world situation, with only the addition of GR. The fact that the rice was refrigerated has nothing to do with bioavailability – that is just repeating the concern of persistence of beta carotene with storage, which again is likely not an issue. Also, just a correction, in the adult study the rice was given with 10 g of butter, not “10%” butter. 5. Biofortification is Risky GR is a “biofortified” product. But there are issues with “nutritional enhancement” and fortification. Due to differences between individuals (old and young, healthy and ill, male and female, overweight and undernourished), some people in the population will get too little of the nutrient and others too much. Overdosing on vitamin A has been linked to an increased risk of birth defects, and in the case of smokers to an increased cancer risk. (6) This, again, is the same objection that anti-fluoridationists use. Biofortification is not inherently risky. Such programs have a long history of safety and effectiveness, from iodine in salt to calcium and vitamin D in milk. It would be nearly impossible to consume so much GR that it results in vitamin A toxicity. Some people might not get enough, but no one is claiming that this one intervention will end vitamin A deficiency. It is simply one additional tool among several to address this serious problem. 6. No Proof that GR is Safe to Eat Genetic modification can result in novel toxins or allergens being created in plants, or changes in nutritional value. New toxins or allergens can appear even if the gene of interest is taken from a non-toxic source, since changes can happen after the gene is inserted into the new host plant. Such unexpected changes are difficult to detect without dedicated animal feeding safety trials. One potential hazard, as pointed out by Prof David Schubert of the Salk Institute in the USA, is associated with retinoic acid, a vitamin A derivative which can damage human fetuses and cause birth defects. (7) The study above in 68 children showed no adverse effects from eating GR, so that is evidence of safety. Sure, there are potential unforeseen consequences from any new cultivar, whether from breeding, mutation breeding, or GM technology. That is why testing is appropriate. So far there hasn’t been a single case of allergic reaction to a GM variety, nor has there been any adverse health outcomes. This is the core of anti-GMO fearmongering, an absurd application of the precautionary principle. Any potential fear is exaggerated, rather than taking a rational risk vs benefit analysis. There is no such thing as zero risk, but the science and history of GM technology has shown the risks to be very low. Compare this to the known morbidity and mortality of vitamin A deficiency. 7. Unethical Trials on Humans Even though GR has not been tested for unexpected toxins or allergens in animal feeding trials, the Golden Rice Humanitarian Board, in conjunction with Tufts University, has conducted three feeding experiments on humans. One included the use of children “without adequate vitamin A nutrition” (10). In 2009 a group of 32 scientists (11) complained to Tufts about this breach of medical ethics and the Nuremburg Code. When the research resulted in the publication of two papers (in 2009 and 2012), there was a furore in China due to the use of children in one experiment without informed consent. The revelation led to the sacking of three Chinese officials and the forced retirement of the lead researcher at Tufts. This is an excellent example of generating controversy in order to demonize a safe and effective technology. The real story here is that the Chinese trial was thoroughly reviewed by Tufts, and as reported by Science: The reviews found no evidence of health or safety problems in the children fed golden rice; they also concluded that the study’s data were scientifically accurate and valid. Indeed, Souvaine’s letter to the USDA stresses that the results “have important public health and nutrition implications, for China and other parts of the world.” However, there were issues with the informed consent and Chinese oversight of the study. While this is unfortunate, it has absolutely nothing to do with the scientific validity of the study. Nor is this an indictment of GR research in general. The 32 scientists were anti-GMO activists, but their objections are presented in a way to make it seem like the scientific community objected to the study. This is all an attempt to distract from the actual results of the study, which show that GR is an effective method of increasing vitamin A levels. Conclusion It is easy to raise objections to any new scientific research or technology. There are always many potential problems, research is never perfect, individuals make mistakes, and new technologies always seem to take more time than initially promised or that it seems like they should. Any new technology or proposed solution can therefore be made to seem like a boondoggle if you obsess over the problems and make every effort to exaggerate them. You can make vaccines seem unsafe, fluoride in public water to be irresponsible, evolution to be uncertain, global warming to be a hoax, psychiatry to be a crime against humanity, or whatever suits your ideological agenda. We are best served, however, not by ideological attacks but by a fair and thorough assessment of risks and benefits and cost effectiveness. The available science and assessments indicate that GR is an extremely promising technology that gives every indication of being safe, effective, and cost-effective. It has the potential to save millions of children from going blind and thousands from dying . Rather than opposing this technology, we should be providing public funding to support the corporate and charitable funding already being used. Field trials should be accelerated and GR should be fast-tracked, while conducting the extensive studies necessary to address every potential aspect of the technology. The potential humanitarian benefit is huge and worth the investment. The misinformation campaign by anti-GMO groups serves only to slow the development and adoption of golden rice. In this case there is a measurable body count and human cost associated with their ideological opposition.
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Q: any way to erase group data-blocks? I linked a group and so It's objects to the scene, then saved. Changed idea and deleted. Saved and closed blender. Opened It again and still find this group data-block in the *.blend file. any way to delete this group? It doesn't let me link one more time that group ... [yes, I changed idea one more time] I also have this orphan data that doesn't get deleted after closing blender.. It was on the linked group. Maybe correlated? UPDATE I also made a piece of the imported group, proxy. but then has been deleted. A: Solved by right click on the linked group and then "unlink group". It was possible only on this tab.
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Laparoscopy versus laparotomy approach of a radical resection for gallbladder cancer: a retrospective comparative study. Laparoscopic approach for gallbladder cancer (GBC) has long been contraindicated, but few recent studies have demonstrated the oncologic outcomes of this treatment. The purpose of this study was to compare the perioperative outcomes and long-term survival for laparoscopic surgery versus traditional open surgery of GBC. Between January 2014 and December 2018, 63 GBC patients who received radical resection were enrolled in this study, with 32 patients in laparoscopic group and 31 cases in laparotomy group. Perioperative data and postoperative survival were retrospectively evaluated. Laparoscopic approach was associated with less intraoperative bleeding (267.20 ± 47.07 vs. 502.60 ± 69.70, P = 0.007), fewer postoperative days of oral diet recovery (2.34 ± 0.31 vs. 3.32 ± 0.35, P = 0.041), and hospital stay (11.03 ± 0.99 vs. 14.35 ± 1.11, P = 0.028). There were no significant differences between two groups regarding other perioperative outcomes. Patients in laparoscopic group showed better 1-year overall survival than those in laparotomy group (72.91% vs. 47.82%, P = 0.086). Subgroup analysis for GBC patients in T3 stages revealed that laparoscopic approach was associated with less intraoperative bleeding (268.00 ± 57.19 vs. 541.50 ± 101.30, P = 0.009), fewer postoperative days of hospital stay (9.87 ± 1.10 vs. 14.90 ± 1.53, P = 0.017), and improved 1-year overall survival (P = 0.023). Subgroup analysis for GBCs in TNM III and TNM IV stages showed comparable intraoperative parameters and postoperative survival between two groups. Laparoscopic surgery for GBCs may offer the comparable perioperative outcomes as conventional laparotomy procedure, and tend to be associated with less intraoperative bleeding, faster oral diet recovery, shorter hospital stay, and improved 1-year overall survival.
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// This file is part of Eigen, a lightweight C++ template library // for linear algebra. // // Copyright (C) 2008 Benoit Jacob <jacob.benoit.1@gmail.com> // // This Source Code Form is subject to the terms of the Mozilla // Public License v. 2.0. If a copy of the MPL was not distributed // with this file, You can obtain one at http://mozilla.org/MPL/2.0/. #ifndef EIGEN_DETERMINANT_H #define EIGEN_DETERMINANT_H namespace Eigen { namespace internal { template<typename Derived> inline const typename Derived::Scalar bruteforce_det3_helper (const MatrixBase<Derived>& matrix, int a, int b, int c) { return matrix.coeff(0,a) * (matrix.coeff(1,b) * matrix.coeff(2,c) - matrix.coeff(1,c) * matrix.coeff(2,b)); } template<typename Derived> const typename Derived::Scalar bruteforce_det4_helper (const MatrixBase<Derived>& matrix, int j, int k, int m, int n) { return (matrix.coeff(j,0) * matrix.coeff(k,1) - matrix.coeff(k,0) * matrix.coeff(j,1)) * (matrix.coeff(m,2) * matrix.coeff(n,3) - matrix.coeff(n,2) * matrix.coeff(m,3)); } template<typename Derived, int DeterminantType = Derived::RowsAtCompileTime > struct determinant_impl { static inline typename traits<Derived>::Scalar run(const Derived& m) { if(Derived::ColsAtCompileTime==Dynamic && m.rows()==0) return typename traits<Derived>::Scalar(1); return m.partialPivLu().determinant(); } }; template<typename Derived> struct determinant_impl<Derived, 1> { static inline typename traits<Derived>::Scalar run(const Derived& m) { return m.coeff(0,0); } }; template<typename Derived> struct determinant_impl<Derived, 2> { static inline typename traits<Derived>::Scalar run(const Derived& m) { return m.coeff(0,0) * m.coeff(1,1) - m.coeff(1,0) * m.coeff(0,1); } }; template<typename Derived> struct determinant_impl<Derived, 3> { static inline typename traits<Derived>::Scalar run(const Derived& m) { return bruteforce_det3_helper(m,0,1,2) - bruteforce_det3_helper(m,1,0,2) + bruteforce_det3_helper(m,2,0,1); } }; template<typename Derived> struct determinant_impl<Derived, 4> { static typename traits<Derived>::Scalar run(const Derived& m) { // trick by Martin Costabel to compute 4x4 det with only 30 muls return bruteforce_det4_helper(m,0,1,2,3) - bruteforce_det4_helper(m,0,2,1,3) + bruteforce_det4_helper(m,0,3,1,2) + bruteforce_det4_helper(m,1,2,0,3) - bruteforce_det4_helper(m,1,3,0,2) + bruteforce_det4_helper(m,2,3,0,1); } }; } // end namespace internal /** \lu_module * * \returns the determinant of this matrix */ template<typename Derived> inline typename internal::traits<Derived>::Scalar MatrixBase<Derived>::determinant() const { eigen_assert(rows() == cols()); typedef typename internal::nested_eval<Derived,Base::RowsAtCompileTime>::type Nested; return internal::determinant_impl<typename internal::remove_all<Nested>::type>::run(derived()); } } // end namespace Eigen #endif // EIGEN_DETERMINANT_H
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Sue Halpern’s Labradoodle Finds Dream Job: Interview Sue Halpern, author of "A Dog Walks Into a Nursing Home: Lessons in the Good Life From an Unlikely Teacher." The book examines the compassion and patience of Halpern and Bill McKibben's labradoodle Pransky, as she does her rounds at a nursing home in Vermont every Tuesday. Photographer: Philip Lewis/Bloomberg Aug. 22 (Bloomberg) -- Pransky stayed home in Vermont with her sitters, possibly listening to Bach while her two humans came to lunch at Bloomberg. Sue Halpern is the author of “A Dog Walks Into a Nursing Home.” Husband Bill McKibben, author and environmentalist, is the force behind 350.org, the grassroots movement to stop global warming. We talked about President Barack Obama’s coming decision on the Keystone XL pipeline -- a watershed moment in his administration -- but quickly focused on Pransky, their 11-year-old Labradoodle. Pransky, a very special dog who comforts the afflicted with her tender paws and searching eyes, trembles when it thunders. Hoelterhoff: So Bach helps? Halpern: I read a study of how dogs with anxiety issues related to music. They played heavy metal and then classical music. It turned out the dog’s anxiety levels came down the most when listening to Bach. Hoelterhoff: The Matthew Passion? Halpern: She’s really not into the masses but the fugues, she likes the fugues. Something about the repetition. Hoelterhoff: How could you tell Pransky wanted a job? You say you could tell she was bored. Pransky’s Job Halpern: Well, you know many dogs are careerists, we just don’t know it. At some point, it was basically the two of us in the house and every single time I would move from one place to another, she would just like -- whoosh -- be there. It became clear that she wanted to do something and I was a very dull person. I had to find people for her that were more interesting. And they turned out to be elderly people in wheelchairs in the nursing home. Hoelterhoff: How do you get to be a therapy dog? Halpern: I trained her for about four months and then we had to take a terrifying test. She had to prove she could handle chaos, for example. They had volunteers marching toward us banging on pots and pans and pushing wheelchairs. The dog had to walk through and not be fazed at all. Hoelterhoff: How was your first visit? Halpern: We walked in the door, and there’s this guy sitting there and he has no legs. His stumps are wrapped in what looked like ace bandages, and she just goes right to them. It’s like: Wow, this is pretty interesting, where are his legs? And she’s sniffing around, and I’m wondering what am I supposed to do? And then I realized, I’m not supposed to do anything. I’m just supposed to be there and let the dog do what the dog does because the man was really thrilled to have her there. One of the things that we all know but we don’t see is that diabetes is an epidemic. In the nursing home there are plenty of people who aren’t that old but who have this disease and it’s devastating. Alzheimer Patients Hoelterhoff: How does Pransky relate to Alzheimer’s patients? Halpern: There was a man who almost seemed to me mute. He wasn’t really functioning in a reactive way to anything that was going on. Pransky kind of put her head near his lap and he almost instinctively reached out and started to pet her. So I asked, “Did you have a dog when you were growing up?” -- not knowing whether he understood anything I said or whether he was listening even. And then he started talking about being a hunter and having hunting dogs. The dog can trigger long-term memories which are much more accessible to people with Alzheimer’s. Hoelterhoff: Do you foresee a day when care for the aged includes a residential dog or any other kind of animal? Halpern: All the studies show benefits. Stress levels go down, and not only for the people in the bed -- they go down for the people who are caring for the people in the bed, which means that you’re actually increasing the capacity of that facility to care for the people who are there and who are sick. One private place has something like 10 dogs and three cats and it sounded like a pet store. But they were finding that it was making everybody happy. There is this movement to try to bring some of that into public facilities, like ours with its cinder blocks and linoleum floors, which does have a resident cat in the memory-care unit. She is actually really interested in the fish tank and less interested in the patients than in the fish. Every Tuesday Hoelterhoff: Always narcissistic, cats! You visit the home every Tuesday. Does Pransky know when it’s Tuesday? Halpern: Yes, when I clip on her special collar with her hospital ID. She’s very proud, she knows what she’s doing. Hoelterhoff: How long is her workday? Halpern: About two hours and it’s very exhausting hours. We both lie down on the couch together afterwards. “A Dog Walks Into a Nursing Home: Lessons in the Good Life From an Unlikely Teacher” is published by Riverhead (312 pages, $26.95). To buy this book in North America, click here. (Manuela Hoelterhoff is executive editor of Muse, the arts and leisure section of Bloomberg News.)
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Bradley Manning, the US soldier charged with leaking confidential government and military documents to whistleblowing platform WikiLeaks, returned to court yesterday for the first day of a pretrial hearing as lawyers argued over what documents were relevant to his case. The 23-year-old has been in jail since May 2010. Manning’s attorney, David Coombs, is seeking documents that assess the impact of the WikiLeaks scandal on the American government but said he had hit “roadblock after roadblock” in his quest to obtain them, reported the American Armed Forces Press Service. Coombs accused the government of providing the requested records too slowly, in a piecemeal fashion or not at all. The prosecution, acting for the CIA, said that Coombs’ requests were “unreasonable” and irrelevant. Lead prosecutor, army Major Ashden Fein claimed that the defence was delaying the trial, and was attempting to “greymail” the government by demanding classified material that the government would be reluctant to release. Army Captain Joshua Tooman, one of Manning’s two military lawyers, asserted that this threatens the defence team’s strategy of proving that the leaks caused little or no damage. Manning faces 22 charges, and the defence team hopes to get 10 of them dismissed before the trial starts. Charges against the 23-year-old include: “aiding the enemy”; “wrongfully causing intelligence to be published on the internet knowing that it is accessible to the enemy”, “theft of public property or records”; “transmitting defense information”; and “fraud and related activity in connection with computers”. The presiding judge at the military tribunal, Colonel Denise Lind, has allocated more days to pretrial hearings in an attempt to break through log-jams. The next pre-trial hearings have been set for 16 to 20 July, 27 to 31 August, and 19 to 20 September. Manning faces a maximum sentence of life in prison if found guilty of the charges.
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@function __reject-iteratee($value, $index, $collection) { $predicate: __this('predicate'); $test: __exec($predicate, $value, $index, $collection); $result: __is-falsey(__exec($predicate, $value, $index, $collection)); @return $result; } @function __reject($collection, $predicate: '__identity', $this-arg: null) { $function: if(__is-list($collection), '__list-filter', '__base-filter'); $predicate: __get-callback($predicate, $this-arg, 3); $_: __scope(( 'predicate': $predicate )); $reject-iteratee: __bind('__reject-iteratee'); $result: __exec($function, $collection, $reject-iteratee); $_: __scope(false); @return $result; } /// /// The opposite of `_filter`; this method returns the elements of `$collection` /// that `$predicate` does **not** return truthy for. /// /// If a property name is provided for `$predicate` the created `_property` /// style callback returns the property value of the given element. /// /// If a value is also provided for `$this-arg` the created `_matches-property` /// style callback returns `true` for elements that have a matching property /// value, else `false`. /// /// If a map is provided for `$predicate` the created `_matches` style /// callback returns `true` for elements that have the properties of the given /// object, else `false`. /// /// /// @access public /// @group Collection /// @param {List|Map|string} $collection The collection to iterate over. /// @param {Function|Map|string} $predicate [_identity] - The function invoked /// per iteration. /// @param {*} $this-arg [null] - The `_this` binding of `$predicate`. /// @returns {List} Returns the new filtered list. /// @example scss /// $foo: _reject((1, 2, 3, 4), is-even); /// // => (1, 3) /// /// $users: ( /// ( 'user': 'barney', 'age': 36, 'active': false ), /// ( 'user': 'fred', 'age': 40, 'active': true ) /// ); /// // using the `_matches` callback shorthand /// $foo: _pluck(_reject($users, ( 'age': 40, 'active': true )), 'user'); /// // => ('barney') /// /// // using the `_matches-property` callback shorthand /// $foo: _pluck(_reject($users, 'active', false), 'user'); /// // => ('fred') /// /// // using the `_property` callback shorthand /// $foo: _pluck(_reject($users, 'active'), 'user'); /// // => ('barney') @function _reject($args...) { @return call(get-function('__reject'), $args...); }
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With Elerts, Emergency Broadcasts Go Digital We've gotten used to experiencing disasters through the kaleidoscopic imagery of mobile devices—and increasingly, emergency responders are using the social media to gather intelligence and alert the public. These trends come together in Elerts, an app devised by a Massachusetts-based startup. Through free apps for Android and iOS, users post reports, broadcast their location, and receive action alerts, while municipal agencies can collect and filter information from eyewitnesses and shuttle them to relevant police, fire, and disaster services. It will be fascinating to see whether Elerts is effective. The company has deep expertise at its command; founder Chris Russo is a deputy fire chief in Massachusetts. But even as emergency services embrace the social media, safety officials struggle to hold the digital public sphere at bay. A spate of controversial arrests of citizens witnessing police incidents—most recently the arrest of Emily Good in Rochester, New York, who was detained while shooting video from her front lawn while police conducted a traffic stop—express the ambivalence public safety officers feel about scrutiny in the networked age. Elerts is reminiscent of the old Civil Defense system, the plane-spotters of World War II that gave way to the fallout shelters and duck-and-cover drills of the Cold War. These public-safety measures kept disaster in the public consciousness, though whether they would have been effective in the event of a nuclear exchange is very doubtful. Whether Elerts will prove to be a more practical way to involve the public in disaster response, or a kind of virtual, mobile air-raid shelter—a social placebo for emergency preparedness—we'll have remain vigilant.
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Q: How to mirror C directory structure using Doxygen groups? I need some basic help using Doxygen on C code. All basic docs are coming out fine, and I want help structuring the big long long list of files and functions. I have a C source tree which looks like this: src/ +--util/ +--file1.h +--file1.c +--file2.h +--file2.c +--stats/ +--file3.h +--etc/ Very standard. Currently doxygen generates a flat file list of all files. We refer to each dub-dir of src/ as a 'module', and so documenting this seems like a nice fit for Doxygen modules/groups. How exactly should I use the grouping commands to mirror the directory structure above? I want to have a module util in the generated docs which links to the file1 and file2 docs. Exactly like JavaDoc would treat a package. Adding the /addtogroup util & @{ tags to each header file generated a mini-site with a flattened list of all data-structures etc within all the headers, which isn't what I expected or wanted. Perhaps this is what doxygen groups are supposed to do though, ie, document an API uniformly when the code is implemented across multiple files? A: A simpler option to using modules is to use @page and @subpage. To get something similar to your described layout you could use the following: @page util Util This page describes util module. @subpage file1 @subpage file2 @page stats Stats This page describes stats module. @subpage file3 @page etc Blah blah blah @page file1 File 1 This is file 1. @page file2 File 2 This is file 2. @page file3 File 3 This is file 3. These comments can of course be contained in one file or many. Typically I'd put the @page file1 in file1.h, @page file2 in file2.h, etc, and the @subpage comments in a more top-level header or main source file.
{ "pile_set_name": "StackExchange" }
X-Ray anomalous scattering study of a charge-ordered state in NaV2O5 Charge ordering of V4+ and V5+ in NaV2O5 has been studied by an x-ray diffraction technique using anomalous scattering near a vanadium K-absorption edge to critically enhance a contrast between the two ions. A dramatic energy dependence of the superlattice intensities is observed below T(C) = 35 K. The charge ordering pattern is the fully charged zigzag-type ladder with the unit cell 2ax2bx4c, but not the chain-type originally proposed for the spin-Peierls state. Charge disproportionation suggested in our model as the average valence V(4.5+/-delta(c)/2) is observed below T(C), showing continuous variation of delta(c) as a function of temperature.
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Methotrexate: an old new drug in autoimmune disease. Methotrexate (MTX) is currently considered, among disease-modifying anti-rheumatic drugs (DMARDs), the 'anchor-drug' in the treatment of rheumatoid arthritis. In the last 25 years, there has been a marked expansion in the use of MTX in different inflammatory diseases. Its low cost, associated to a good long-term efficacy and safety profile, justifies the use of MTX as a first-line disease-modifying drug or alternatively, a steroid-sparing medication in this field of medicine. Although new emerging options, including biological treatments, are being established in the therapeutic scenario, the good cost/benefit ratio of MTX supports the choice of this drug in combination with these newer therapies, enhancing the efficacy of these combination therapies and decreasing the risk of potential side effects.
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Q: unable to auto-play with mediaelement js in chrome I am trying to autoplay audio from a live stream audio link: http://163.172.165.94:8728/;stream.mp3 I tried adding autoplay, and by doing: $('#player2').mediaelementplayer({ autoplay: true }); nothing work, tried every single answer from stack overflow. Can someone help me? What am I doing wrong? <link rel="stylesheet" href="https://cdn.jsdelivr.net/mediaelement/latest/mediaelementplayer.css"> <div class="media-wrapper"> <audio id="player2" preload="auto" autoplay style="max-width:100%;"> <source src="http://163.172.165.94:8728/;stream.mp3" type="audio/mp3"> </audio> </div> <script src="https://code.jquery.com/jquery-3.3.1.slim.min.js" integrity="sha384-q8i/X+965DzO0rT7abK41JStQIAqVgRVzpbzo5smXKp4YfRvH+8abtTE1Pi6jizo" crossorigin="anonymous"></script> <script src="https://cdn.jsdelivr.net/mediaelement/latest/mediaelement-and-player.min.js"></script> <script> $('#player2').mediaelementplayer(); </script> A: This will help you to auto play when it is loaded <audio id="player2" preload="auto" autoplay style="max-width:100%;"> <source src="<?php echo $audidec; ?>" type="audio/mp3"> </audio> $('audio').mediaelementplayer({ success: function (mediaElement) { mediaElement.play(); mediaElement.addEventListener('ended', function (e) { alert("finished"); }, true); } });
{ "pile_set_name": "StackExchange" }
Buddhist moral psychology represents a distinctive contribution to contemporary moral discourses. Most Western ethicists neglect to problematize perception at all, and few suggest that ethical engagement begins with perception. But this is a central idea in Buddhist moral theory. Human perception is always perception-as. We see someone as a friend or as an enemy; as a stranger or as an acquaintance. We see objects as desirable or as repulsive. We see ourselves as helpers or as competitors, and our cognitive and action sets follow in train. We can explain or express this in the Buddhist language of sparsa (contact), vedanā (hedonic tone), samjña (ascertainment), chanda (action selection) and cetanā (intention). Every perceptual episode, while it might begin with sensory contact, has some hedonic tone. We experience the object with which we have contact on a continuum from pleasurable to distasteful. Perception involves ascertainment–the representation of the object perceived as of a kind. This ascertainment and hedonic tone lead us to ready action appropriate to the object and its affective valence, and as we do so, we form an intention to act, perhaps before we even become aware that we do so. Perception is always part of a contact-cognition-action cycle in which there is no bare awareness of an object disjoint from our interests or affect. It is hard to avoid the conclusion that perception itself is morally charged. If I see women as tools, or Latinos as fools, the damage is done. That perception involves the formation of intentions that are morally problematic on their face, and that lead to harms of all kinds. Perceiving in that way makes me a morally reduced person. If, on the other hand, I perceive people as opportunities to cooperate, or to provide benefit, I perceive in a way that involves the construction of morally salutary intentions, good on their face, and productive of human goods. For this reason, much Buddhist ethical discourse eschews the articulation of duties, rules or virtues, and aims at the transformation of our mode of perceptual engagement with the world. Moral cultivation, on this view, is the cultivation of a way of seeing, not in the first a instance a way of acting. The importance of moral perception is well-illustrated by the phenomenon of implicit bias. Since Greenawald et al. (1998) a raft of evidence has demonstrated both the omnipresence and the pernicious effects of implicit bias. Implicit bias—the subliminal association of negative traits with members of groups that are the victims of bias and positive traits with dominant groups—is evident in the implicit bias association task, in experiments asking professionals to evaluate resumés with stereotypical names, in salary decisions regarding candidates of opposite genders, in tasks asking participants to identify objects carried by individuals in rapid presentation, in medical decisionmaking, etc. It is far too widespread, and far too robust a finding to be dismissed. While it is possible to reduce the effect of implicit bias through training, that training must be regular, and must be regularly repeated if the effects are to be significant or lasting, and the most effective methods in reducing implicit bias are affective, not cognitive. Changing people’s explicit beliefs or attitudes, and even making them aware of their own implicit bias has no real effect. Only training that involves changing the immediate affective valence of the perception of others has any lasting effect. Implicit bias demonstrates that the roots of virtue and vice, or of good and evil lie not in what we do, but in how we see. The fact that in the moment we have no control over our implicit bias may excuse us from culpability of that bias in the moment, but it does not excuse us from responsibility to transform ourselves so as to eliminate that bias. Involuntariness, that is, may excuse the act, but it does not absolve us of moral blameworthiness. The same goes, mutatis mutandis, for morally salutary perceptual sets. We have an obligation, once we recognize our implicit biases, to remediate them. We cannot reflectively endorse being the kind of person who perceives the world in this way. Implicit bias is only the tip of the moral iceberg of our perceptual lives. The very processes that are salient when we investigate racial or gender bias in these disturbing studies are ubiquitous in our psychology. It is not only racial stereotyping that is problematic; the representation of Maseratis as desirable, or of insect protein as undesirable may be just as morally charged, and just as deeply implicated in perceptual processes. And the powerful effects not merely of implicit social pressures at work in the cases of racial stereotyping, but also the deliberate efforts of advertisers, demagogues, preachers and moral philosophers to distort our perception must be morally scrutinized, for just as implicit bias demonstrably distorts our explicit reasoning and judgments in invidious ways, the panoply of subliminal processes to which it is kin have the same effect across the domains in which agency is manifest. A Buddhist moral psychology shows us just how and why our moral lives begin with perception, and Buddhist meditative practices provide an avenue to eradicate the vices of perception and to encourage more virtuous ways of seeing the world. Featured image credit: Prayer Wheel, by Brandon. CC-BY-2.0 via Flickr.
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Emory and the Confederacy, Part Three: The case of A. B. Longstreet Generations of students have lived in Longstreet–Means Hall without knowing much, if anything, about the Emory presidents for whom the building was named—Augustus Baldwin Longstreet and Alexander Means. Augustus Baldwin Longstreet Alexander Means Longstreet had practiced law and achieved fame and fortune as an author before entering the Methodist ministry and then becoming president of Emory (1840–48). Means was a minister and scientist as well as an educator. He served only one year as president (1854–55) because the trustees tired of his trying to juggle his job at Emory while teaching at Augusta Medical College and Atlanta Medical College. Both Means and Longstreet were slave owners and supporters of the Confederacy, but Longstreet was more prominent in defending the Old South. A native of Augusta, Longstreet attended a private school in South Carolina, where he boarded in the home of John C. Calhoun, the state-rightist and apologist for slavery. Following Calhoun’s example, Longstreet attended Yale, then practiced law back in Augusta, eventually becoming a judge. He also bought the Augusta Chronicle, a newspaper that he renamed the State Rights Sentinel, which advocated political positions in harmony with Calhoun’s anti-Federalist views. Longstreet’s lasting literary achievement, however, was a series of humorous stories about life in rural Georgia. He gathered some of these into a book, Georgia Scenes, which reviewers at the time universally praised and later critics viewed as a precursor to a genre perfected by Mark Twain. In 2000, Longstreet was inducted into the Georgia Writers Hall of Fame, largely on the basis of Georgia Scenes. The book’s financial success provided Longstreet the wherewithal to enjoy a comfortable life. Shortly after its publication in 1835, however, he entered the Methodist ministry. He was serving a church in Augusta in 1839 when the board of trustees of Emory College offered him the college presidency. Longstreet accepted and served until resigning in 1848 to become the president of Centenary College in Louisiana and later president of the University of Mississippi and the University of South Carolina. During the Civil War, he returned to Oxford, Mississippi, where Union soldiers used his personal papers to build a fire and burn down his house. When Longstreet stepped into the president’s office, Emory College had completed only three terms and was hanging tenuously to existence. A deep recession in 1837 had left the college nearly bankrupt. The trustees no doubt saw in Longstreet a person of intellect, energy, and renown who could lift the college out of its trouble. He traveled throughout the Southeast and as far as New York to garner support for the college. Longstreet also used personal funds to keep the college afloat. On leaving the presidency in 1848, he wrote off the $4,800 the college owed him in loans and back salary—about $149,000 in 2015. All of that totes up on the positive side of the Longstreet ledger. On the debit side, Longstreet twice became embroiled — and not in a positive way, by our modern lights — in controversy over slavery during his presidency. The first instance grew out of the ownership of slaves by Bishop James O. Andrew, president of the Emory College board of trustees. When the national conference of the Methodist Episcopal Church met in New York City in 1844, abolitionist sentiment in the church prompted a month-long debate about Bishop Andrew’s fitness for office in view of his ownership of slaves. The church divided over the issue. Longstreet was thick in the middle of this debate, firmly on the side of Bishop Andrew and the slave-owning South. Longstreet also became closely associated with slavery through A Voice from the South, a book he published in 1847 while president of Emory. Framed as ten letters from the state of Georgia to the state of Massachusetts, the volume is an extended argument not in defense of slavery but against the hypocrisy of the North. Longstreet points out that Georgia prohibited slavery until 1750, while New England profited handsomely from the slave trade. Now, with an industrial economy employing what Longstreet calls “white slaves,” the North has had a change of heart about slavery while not changing its heart about “negroes,” whom it excludes from Northern society in various ways. The book is a justification of increasingly popular Southern support for secession. Remembering Longstreet at Emory, then, requires a balancing of accounts. On one side of the ledger lies his defense of a Southern way of life that we now see as reprehensible. On the other side lies his nearly decade-long work to help the struggling college to survive and, indeed, begin to flourish. In the next post, more about the building named for Presidents Longstreet and Means. 2 thoughts on “Emory and the Confederacy, Part Three: The case of A. B. Longstreet” > emoryhistorian posted: “Generations of students have lived in > Longstreet–Means Hall without knowing much, if anything, about the Emory > presidents for whom the building was named—Augustus Baldwin Longstreet and > Alexander Means. Longstreet had practiced law an” >
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(updated at 5:03 p.m. EST) Motorola Solutions announces the sale of its enterprise unit to Zebra Technologies for $3.45 billion cash, marking Motorola Solutions' exit from the enterprise space. Instead, the company will focus on mission-critical communications for the government and public-safety markets, according to Motorola Solutions Chairman and CEO Greg Brown. Motorola Solutions today announced an agreement to sell its enterprise unit to Zebra Technologies near the end of the year for $3.45 billion cash, which will allow the communications giant to focus on mission-critical communications for the government and public-safety markets. “Last year, we undertook a thorough review of our strategy and concluded that the synergies between our government and enterprise businesses were not as great as the value we could create by being singularly focused on our core government and public-safety business,” Motorola Solutions Chairman and CEO Greg Brown said during an investor conference call. “Going forward, we will have absolute clarity of purpose and mission, as we serve customers globally with our suite of mission-critical communications solutions. “ “From a FirstNet perspective, we continue to work closely with them,” Brown said. “The relationship is, quite frankly, as good as it’s ever been between Motorola Solutions and FirstNet. We’re very excited about embarking on the LA-RICS implementation, which will have to be concluded in 2015. “Obviously, [the FirstNet buildout] occurred a little bit later than we thought a year or two ago, but we still think it’s a fantastic global opportunity. We look forward to working with FirstNEt and the requisite authorities around the globe.” Motorola Solutions will retain its iDEN technology, as well its mission-critical portfolio, according to company spokesman Steve Gorecki. “Sales of MOTOTRBO and other solutions that are part of Motorola Solutions’ professional commercial radio business will continue without limitation as part of the company’s continued government business,” Gorecki said in a statement e-mailed to IWCE’s Urgent Communications. “Utilities and other critical-infrastructure customers around the world will continue to be able to select from a portfolio of mission-critical solutions from Motorola Solutions that includes ASTRO 25, TETRA and MOTOTRBO.” Websites are now required by law to gain your consent before applying cookies. We use cookies to improve your browsing experience. Parts of the website may not work as expected without them. By closing or ignoring this message, you are consenting to our use of cookies.
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[Dermatologic diseases in patients with AIDS]. This short review deals with the cutaneous manifestations of the acquired immune deficiency syndrome (AIDS), which comprise Kaposi's sarcoma, as an important marker disease for AIDS, as well as various skin infections caused by bacteria, fungi and viruses. In patients at risk of acquiring AIDS, an extensive immunological investigation should be performed if skin infections are established. In addition, a large number of cutaneous complications encountered in AIDS patients have an immunological background, e.g. an extreme hypersensitivity to trimethoprim-sulfamethoxazole. Therefore, the dermatological investigation of patients at risk of acquiring AIDS is urgently recommended as a regular part of the general check-up.
{ "pile_set_name": "PubMed Abstracts" }
The best-selling author behind The Shining has returned to its central character, 36 years after the book was first published, for his latest novel. Doctor Sleep begins a year after the events at the end of The Shining, and follows Danny Torrance to adulthood. He spoke to the BBC's arts editor Will Gompertz about why Jack Torrance is his most autobiographical character and why he hated Stanley Kubrick's film version.
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<!doctype html> <html lang="en"> <head> <meta charset="UTF-8"> <title>判断UA</title> </head> <body> <script> var UA = window.navigator.userAgent; var ua = UA.toLowerCase(); var browserRegExp = { ie:/msie\s*(\d+(?:\.\d+)?)+/, chrome:/chrome\/(\d+(?:\.\d+)?)+/, firefox:/firefox\/(\d+(?:\.\d+)?)+/, safari:/version\/(\d+(?:\.\d+)?)\s*safari/, opera:/opera[ |\/](\d+(?:\.\d+)?)/ }; $ = {}; $.browser = 'unknow'; $.browserVersion = 0; function checkUA(ua,browser,version){ ua = ua.toLowerCase(); for(var i in browserRegExp){ var match = browserRegExp[i].exec(ua); if(match){ $.browser = i; if(browser===i && version==match[1]){ }else{ console.log(browser+'|'+version+'|'+match[1]+':'+ua); } break; }else{ // console.log(ua); } } } var arr = [ ['chrome',19.0,'Mozilla/5.0 (Windows NT 6.1; WOW64) AppleWebKit/536.3 (KHTML, like Gecko) Chrome/19.0.1061.1 Safari/536.3'], ['chrome',24.0,'Mozilla/5.0 (Windows NT 6.2; WOW64) AppleWebKit/537.14 (KHTML, like Gecko) Chrome/24.0.1292.0 Safari/537.14'], ['chrome',15.0,'Mozilla/5.0 (Macintosh; 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Sierra de Béjar Sierra de Béjar may refer to: Sierra de Béjar (mountain range) a mountain range in Spain. Sierra de Béjar (comarca) a comarca in the province of Salamanca.
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