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clinical history is not helpful , and only 50% of ingested toothpicks are radioopaque 2 .
a 82yearold woman was admitted to our university hospital because of fever of unknown origin ( t 39c ) , leukocytosis ( wbc 16730 mmc , n 85% ) , and severe inflammatory markers ( pcr 20.90 mg / dl ) .
for this reason , patien... | key clinical messageingestion of foreign bodies is a common clinical problem , but intrahepatic migration is an exceptional occurrence . clinical history is not helpful . abdominal ultrasonography and ct
are fundamental to exclude surgical causes of fever of unknown origin .
laparoscopic segmental liver resection i... |
craniomandibular disorders ( cmd ) and their relevance to orthodontics have been a highly debated topic in recent years .
craniomandibular disorders ( cmd ) relate to discomfort of the temporomandibular joint ( tmj ) .
the disorder is multifactorial with a degree of psychogenic influence varying throughout an indiv... | the aim of this paper is to bring into focus the literature on the choice of the mandibular reference position in orthodontic treatment ; of a particular reference to this paper is intercuspal position , centric relation position , or therapeutic position . to give a comprehensive account of the literature review on cr... |
rete testis is an anastomosing network of delicate tubules located in the hilum of the testicle ( mediastinum testis ) that carries sperm from the seminiferous tubules to the vasa efferentia .
rete tubular ectasia is a disorder of the rete testis in which many benign cysts are present .
it is a rare benign entity h... | cystic / tubular ectasia of the rete testis is a rare benign entity and must be differentiated from testicular neoplasm .
we report a case of bilateral rete testis - associated epididymal cyst in patient with abdominal mass .
scrotal swelling clinically was interpreted as testicular neoplasm . |
taste and smell stimulation of the oropharyngeal cavity elicits several digestive , endocrinological , thermogenic , cardiovascular , and renal responses , which are collectively termed cephalic phase responses [ 13 ] .
the gastric phase response , however , involves fewer reflexive responses than the cephalic phase ... | in this study we investigated the effects of intragastric infusion of palatable basic taste substances ( umami , sweet , and salty ) on the activity of the vagal gastric afferent nerve ( vga ) , the vagal celiac efferent nerve ( vce ) , and the splanchnic adrenal efferent nerve ( sae ) in anesthetized rats . to test th... |
gynecologic surgeons are often presented with new surgical techniques , procedures , and devices given the rapid advancement of science and technology for minimally invasive surgery . during residency training ,
new techniques are adopted under the watchful supervision of a faculty member . for practicing surgeons , ... | purposesuccessful adoption of a new surgical procedure varies among practicing surgeons , and skill acquisition depends on the surgeon s innate ability , the complexity of the technique , and training .
we report intraoperative and near - term postoperative outcomes from the acessa procedure conducted by minimally in... |
conditional genetic deletion of kv12.2 from cultured hippocampal pyramidal neurons results in hyperexcitability supplementary figure 4 . | we show here that the voltage - gated k+ channel kv12.2 is a potent regulator of excitability in hippocampal pyramidal neurons .
genetic deletion and pharmacologic block of kv12.2 significantly reduced firing threshold in these neurons .
kv12.2/ mice displayed signs of persistent neuronal hyperexcitability includin... |
for millennia , fungi have been appreciated by human beings as edible and medical resources .
they are extraordinary species of natural medicines that have long been used around the world .
medicinal fungi , which are used as decoctions and essences , are also normally applied as alternative medicine in china , kor... | the fungus species wolfiporia extensa has a long history of medicinal usage and has also been commercially used to formulate nutraceuticals and functional foods in certain asian countries . in the present study
, a practical and promising method has been developed to discriminate the dried sclerotium of w. extensa co... |
three macaca fascicularis were used in this study ( one female , 6 years old , and two males , 6 and 9 years old ) .
procedures for handling these subjects were approved by the university of rochester 's committee for animal research . before each experiment , ketamine ( 1020 mg / kg ) and valium ( 0.25 ml / kg ) wer... | purposetwo - photon excited fluorescence ( tpef ) imaging has potential as a functional tool for tracking visual pigment regeneration in the living eye .
previous studies have shown that all - trans - retinol is likely the chief source of time - varying tpef from photoreceptors .
endogenous tpef from retinol could ... |
high concentrations of trace elements , alkaline earth metals , heavy metals , and metalloids in the organs of animals can be considered an indication of environmental pollution and the amounts of these elements in feed . in the present study , we measured the concentrations of strontium ( sr ) , barium ( ba ) , cadmiu... | this study was conducted to measure the concentrations of strontium ( sr ) , barium ( ba ) , cadmium ( cd ) , copper ( cu ) , zinc ( zn ) , manganese ( mn ) , chromium ( cr ) , antimony ( sb ) , selenium ( se ) , and lead ( pb ) in canine liver , renal cortex , and renal medulla , and the association of these concentra... |
there has been an increase of invasive candidiasis cases caused by non - albicans candida species compared to candida albicans over the last three decades ( 1 ) .
these species presented different drug susceptibility patterns towards current and established antifungals ( 2 ) . therefore , there is an urgent need to a... | background : the number of invasive candidiasis cases has risen especially with an increase in the number of immunosuppressed and immunocom promised patients .
the early detection of candida species which is specific and sensitive is important in determining the correct administration of antifungal drugs to patients.... |
maxillofacial fractures are more prevalent in large cities due to heavy traffic and high incidence of violence .
the causes , types , and sites of these fractures seem to vary across geographical location .
different studies have shown a relationship between maxillofacial fractures , defined sex and age groups , le... | aimto investigate the epidemiological characteristics of maxillofacial fractures and associated fractures in patients seen in the oral surgery unit of mulago hospital , kampala , uganda.methodologya six - month prospective study was conducted . data collected included socio - demographic factors , type and etiology of ... |
multiple myeloma ( mm ) is a rare post - germinal center b - cell malignancy .
a search of the english literature for synchronous cases of lung cancer and mm revealed only 5 cases ( table 1 ) [ 15 ] .
gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor ( egfr - tki ) used to treat non - small... | the coexistence of lung cancer and multiple myeloma ( mm ) is rare . a search of the english literature revealed only 5 case reports to date .
we describe a case of mm that presented in a 78-year - old lung cancer patient after 20 months of treatment with gefitinib , an epidermal growth factor receptor tyrosine kinas... |
oral verrucous carcinoma ( vc ) , as defined by ackerman , is a rare , nonmetastasizing , well - differentiated variant of oral squamous cell carcinoma ( scc ) .
although vc has a slow and continuous local growth pattern ; patients with vc have an excellent prognosis .
vc is occasionally developed in the oral cavit... | verrucous carcinoma ( vc ) of oral cavity is a rare variant of well - differentiated squamous cell carcinoma and squamous papilloma is a benign proliferation of the stratified squamous epithelium , which results in a papillary or verrucous exophytic mass .
there is a certain clinical similarity between squamous cell ... |
the inhabitants of such countries ( about 1,110,000,000 ) correspond to 16% of the world population .
this means that asbestos use continues in a large part of the world . in this context
it would be opportune that data on the incidence of malignant mesothelioma , a sentinel event indicating the effects of asbestos... | background : mesothelioma incidence has taken epidemic proportions in various countries . the trend of the epidemic remains undefined.objective:to collect the most recent available data on mesothelioma incidence in order to determine the present trend of the epidemic.materials and methods : data of the cancer and mesot... |
increased time spent on sedentary activities and decreased time spent on physical
activities of moderate - to - vigorous intensity have been reported to be independently
associated with the risk of developing metabolic syndrome and its components1 .
physical activity is a vital part of a
comprehensive weight lo... | [ purpose ] lack of physical activity and an uncontrolled diet cause excessive weight gain ,
which leads to obesity and other metabolic disorders .
studies have indicated that brisk
walking and aerobics are the best methods for controlling and reducing weight and body
mass composition .
[ subjects and methods... |
prostate cancer ( pc ) is the most common malignant tumour among european men ( accounting for 22.2% of the total cancer incidence ) and the third most frequent cause of cancer death ( 9.3% of all cancer deaths ) .
a systematic 10 - 12 core transrectal ultrasound ( trus)-guided prostate biopsy is a state - of - the -... | introductionhistorical nomograms for the prediction of cancer on prostate biopsy , developed in the sextant biopsy era are no more accurate today .
the aim of this study was an independent external validation of a 10-core biopsy nomogram by chun et al .
( 2007).material and methodsa total of 322 patients who presen... |
this study is part of a larger ongoing prospective cohort study examining health outcomes and cost of hm feedings for vlbw infants conducted in a 57-bed tertiary nicu in chicago .
( 14 ) for the larger study , all eligible infants and their mothers were offered enrollment , and data were collected from the time of th... | objectivethe objective of this study was to compare the currently used human milk ( hm ) quality indicators that measure whether very low birthweight ( vlbw ; < 1500 g birthweight ) infants ever received hm and whether they were still receiving hm at discharge from the neonatal intensive care unit ( nicu ) to the act... |
unless otherwise stated , chemicals were obtained from sigma chemical co. ( poole , uk ) , cell culture consumables from invitrogen life technologies ( paisley , uk ) , and antibodies from dako cytomation ( ely , uk ) .
the estrogen - responsive breast carcinoma mcf-7 cell line was grown in dulbecco s modified essent... | backgroundwithin mixtures , interactions between different xenobiotics may occur to give rise to additive , synergistic , inhibitory and/or stimulatory effects in target cells .
the role that xenobiotics individually or in mixtures , and at environmental concentrations , play in the etiology of common human diseases ... |
lung cancer is the leading cause of death in developed countries and is increasing at alarming rates in developing countries .
although lung carcinoma remains more common in males than females , the difference is decreasing .
cytological methods in the diagnosis of malignant lesions of the lungs has been generally ... | background : lung cancer is the leading cause of death in developed countries and is increasing at alarming rates in developing countries .
cytological techniques such as bronchoalveolar lavage ( bal ) , bronchial brushing ( bb ) , and fine needle aspiration cytology ( fnac ) can aid in the early diagnosis of lung ma... |
chronic inflammatory demyelinating polyneuropathy ( cidp ) , as the name implies , is an autoimmune disorder of unknown etiology in two thirds of the patients ; however , in remaining one third , an etiological cause might be found .
some currently described etiologies include : gammopathies including monoclonal gamm... | various forms of neuropathy are seen diabetic patients ; chronic inflammatory demyelinating polyneuropathy ( cidp ) seems not to be infrequent neuropathy in patients suffering from diabetes and it seems to be more common than in the general population ; on the contrary , some authorities do not support pathogenetic ass... |
stevens - johnson syndrome ( sjs ) and toxic epidermal necrolysis ( ten ) are potentially serious cutaneous reactions , characterized by high fever , wide - spread blistering exanthema of macules and atypical target - like lesions , accompanied by mucosal involvement . in sjs ,
detachment of the epidermis is less tha... | objective : cutaneous drug reactions are the most common type of adverse drug reactions .
adverse cutaneous drug reactions form 2 - 3% of the hospitalized patients .
2% of these are potentially serious .
this study aims to detect the drugs commonly implicated in steven johnson syndrome - toxic epidermal necrosis ... |
dysgenetic polycystic disease ( dpd ) of salivary gland is a rare cystic condition with distinctive histopathology resembling that of polycystic condition affecting the kidneys and pancreas .
this disease is thought to be a developmental disorder of the distal ductal system of the salivary gland and is common among w... | dysgenetic polycystic disease ( dpd ) is a rare cystic lesion affecting mainly the parotid salivary glands with only 14 reported cases in english literature .
dpd of parotids is more common in females , common in younger age group , mostly bilateral in occurrence and commonly affects the superficial lobe .
surgery ... |
the patient was a 66-year - old woman from guangzhou , guangdong province , china .
she worked on a household farm that cultivated vegetables but not animals . on january 30 , 2014 , she purchased from a poultry market 3 live chickens , which she slaughtered and cooked that day . according to the patient , these chic... | of the 400 cases of avian influenza ( h7n9 ) diagnosed in china since 2003 , the only travel - related cases have been in hong kong and taiwan .
detection of a case in a chinese tourist in sabah , malaysia , highlights the ease with which emerging viral respiratory infections can travel globally . |
parkinson 's disease ( pd ) is a common progressive neurodegenerative disorder that can be accurately diagnosed .
a recent meta - analysis study indicated that standardized all - age prevalence of 51.3 to 176.9 per 100 000 in door - to - door surveys and prevalence in record - based studies ranged from 35.8 to 68.3 ... | parkinson 's disease ( pd ) is a progressive extrapyramidal motor
disorder .
pathologically , this disease is characterized by the selective dopaminergic ( daergic ) neuronal degeneration in the substantia nigra . correcting the da deficiency in pd with levodopa ( l - dopa )
significantly attenuates the motor sym... |
there are a number of dental anomalies in existence that affect the tooth structure , shape , and size . while the etiology of these anomalies is generally not clear , certain factors associated with them are thought to affect the tooth at the histo- and morpho - differentiation stages of its development .
some of th... | congenitally missing teeth is a common feature for the third molars . however
, missing teeth , macrodontia and radiculomegaly occurring in a single patient is very rare .
this article describes a case of agenesis of mandibular second premolars , radiculomegaly with dilacerations of a canine tooth together with elo... |
imatinib is the only first - line targeted therapy approved to treat patients with gastrointestinal stromal tumors ( gist ) , both as adjuvant therapy following resection and in the advanced / metastatic setting [ 13 ] .
imatinib has significantly improved outcomes for patients with metastatic gist compared to histor... | purposethis review examines the clinical evidence showing that imatinib can be prescribed to treat recurrence or progression of gastrointestinal stromal tumors ( gist ) in patients who interrupted first - line imatinib therapy in the adjuvant or advanced / metastatic setting.methodologya literature search was performed... |
as the 3d ( three dimensional ) dental model can be acquired easily through different kinds of intra or extra oral measurement methods including optical digitizers [ 13 ] , ct ( cbct ) [ 4 , 5 ] and mri , cad ( computer - aided design)/cam ( computer - aided manufacturing ) has been introduced to dentistry and achieved... | an integrated single - tooth modeling scheme is proposed for the 3d dental model acquired by optical digitizers .
the cores of the modeling scheme are fusion regions extraction , single tooth shape restoration , and single tooth separation . according to the valley shape - like characters of the fusion regions betw... |
rna analysis has emerged as a reliable method of body fluid identification for forensic use [ 1 - 7 ] .
conventionally , immunological , enzymatic , and chemical detection of specific protein markers is used [ 8 - 10 ] .
for example , prostate - specific antigen has been used for semen and hemoglobin for blood iden... | rna analysis has become a reliable method of body fluid identification for forensic use .
previously , we developed a combination of four multiplex quantitative pcr ( qrt - pcr ) probes to discriminate four different body fluids ( blood , semen , saliva , and vaginal secretion ) . while those makers successfully iden... |
diabetic retinopathy ( dr ) is one of the most common microangiopathic complications of patients with diabetes mellitus ( dm ) .
dr is an ocular manifestation of dm , affecting up to 80% of all patients who have had dm for 10 years or more .
several studies have suggested that low - grade inflammation is an importa... | diabetic retinopathy ( dr ) is a major microvascular complication in diabetics , and its mechanism is not fully understood .
toll - like receptor 4 ( tlr4 ) plays a pivotal role in the maintenance of the inflammatory state during dr , and the deletion of tlr4 eventually alleviates the diabetic inflammatory state . to... |
the main advantage of research conducted in small animals is owed to their short life cycle and the possibility of genetic manipulation .
however , most of the observations in small animals have been based in the past on surgery and histological postmortem analysis .
few years ago , research applications of noninva... | ultrasound biomicroscopy ( ubm ) is a noninvasive multimodality technique that allows high - resolution imaging in mice .
it is affordable , widely available , and portable .
when it is coupled to doppler ultrasound with color and power doppler , it can be used to quantify blood flow and to image microcirculation a... |
the following online material is available for this article : table s1 allele size and frequency for each locus scored in four populations of plebeia remota . | genetic diversity is a major component of the biological diversity of an ecosystem .
the survival of a population may be seriously threatened if its genetic diversity values are low . in this work ,
we measured the genetic diversity of the stingless bee plebeia remota based on molecular data obtained by analyzing 1... |
in the previous issue of critical care , martini and colleagues assessed the effects of haemodilution with either polyethylene glycol ( peg)ylated albumin or a commercially available hydroxyethyl starch - based colloid in a hamster haemorrhage model .
the aim of perioperative haemodilution , also termed acute normo... | the aim of perioperative haemodilution is to reduce loss of red blood cells during elective surgery .
the oncotic and molecular characteristics of the various plasma substitutes employed determine how effectively normovolaemia is maintained , and their non - oncotic effects include alterations in microvascular perfus... |
sudden cardiac death ( scd ) accounts for almost 20% of total mortality in western europe and the usa , and ventricular fibrillation ( vf ) is the most common underlying arrhythmia [ 1 , 2 ] .
vf arises through multiple mechanisms , depending on the underlying cardiac pathology . in the last decade
, considerable p... | sudden cardiac death from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality .
this multifactorial , complex condition clusters in families , suggesting a substantial genetic cause .
we carried out a genomewide association study ( gwas ) for sudden cardiac... |
the gastrointestinal tract is highly susceptible to many species of intestinal parasites ( cyntia , 2011 ) .
infected avian species have been reported to experience inflammation , lesions , hemorrhaging , hyperplasia , necrosis , and even death ( greiner and ritchie , 1994 ) .
even parasites that were thought to ha... | parasitic nematodes that infect quail have been understudied and long been dismissed as a problem in quail management . within the rolling plains ecoregion of texas , an area that has experienced quail population boom and bust cycles and ultimately a general decline , the need to determine why northern bobwhite ( col... |
the hpfs is a prospective cohort study of 51,529 male health professionals aged 4075 years in 1986 . in this study , after excluding participants with cvds or cancer at baseline , 3,497 men remained who reported a diagnosis of type 2 diabetes on any questionnaire from 1986 to 2004 .
coffee intake was assessed using a... | objectivecoffee consumption has been linked to detrimental acute metabolic and hemodynamic effects .
we investigated coffee consumption in relation to risk of cvds and mortality in diabetic men.research design and methodswe conducted a prospective cohort study including 3,497 diabetic men without cvd at baseline.resu... |
acute pancreatitis ( ap ) is a disease of varied etiology , yet each produces a similar pattern of disease , indicating that they all converge at a common point , to initiate a cascade of events resulting in ap [ 1 , 2 ] .
the overwhelming evidence indicates that this common event involves the premature activation an... | acute pancreatitis ( ap ) is a common emergency condition . in the majority of cases
, it presents in a mild and self - limited form .
however , about 20% of patients develop severe disease with local pancreatic complications ( including necrosis , abscess , or pseudocysts ) , systemic organ dysfunction , or both .... |
orthotopic liver transplantation is the only definitive therapeutic option for patients with end - stage liver disease .
however , invasive fungal infections are an important cause of post - transplantation mortality in solid organ recipients , and their incidence , particularly for candidiasis and aspergillosis , va... | liver transplantation is the only available treatment for some patients with end - stage liver disease . despite reduction in mortality rates due to advances related to surgical techniques , intensive medical management and immunosuppressive therapy ,
invasive fungal infections remain a serious complication in orthot... |
in 2013 there will be an estimated 238,590 new cases of prostate cancer ( pca ) in the united states resulting in an estimated 29,720 deaths .
approximately 1530% of new pca diagnoses are classified as high risk , defined by d'amico as psa > 20 ng / ml , biopsy gleason score 810 pca , or clinical stage t2c disease .... | objective . to assess the impact of comorbidity , race , and marital status on overall survival ( os ) among men presenting for prostate biopsy with psa > 20 ng / ml . methods .
data were reviewed from 2000 to 2012 and 78 patients were included in the cohort .
we analyzed predictors of os using a cox proportional ... |
diabetes is the most prevalent disease caused by metabolic disorders ; in other words , it is the most prevalent endocrine disease . nowadays , diabetes is the fifth leading cause of mortality in western societies and the fourth reason of visiting doctors .
diabetes is a growing threat to world health so that world h... | background : considering the effect of socio - economic factors on the emergence of chronic diseases and the importance of this aspect of diseases for policy makers and authorities of health care organizations , this study tried to investigate the role of these factors in type 2 diabetes and its consequences , which ca... |
an adverse cutaneous reaction caused by a drug is any undesirable change in the structure or function of the skin , its appendages or mucous membranes , and it encompass all adverse events related to drug eruption , regardless of the etiology .
cutaneous adverse drug reactions ( cadr ) are the most frequent of all ma... | background : cutaneous adverse drug reactions ( cadr ) are the most frequent of all manifestations of drug sensitivity and manifest with varied and diverse morphology.aims:to study the prevalence and clinical spectrum of cadr among patients attending outpatient department ( opd ) in a tertiary care hospital.materials a... |
mr john frewer study concept , design and final review.mr ibraz siddique literature search , drafting the articles and revision.mr david walker critical revision of drafts.dr preetha chengot
written informed consent was obtained from the patient for publication of this case report and accompanying images ... | highlightsthe attached gingiva is a rare site for metastasis in the oral cavity.metastasis to the oral cavity usually indicates disseminated malignant disease.clinicians must be vigilant when presented with an oral soft tissue mass in patients with a known underlying malignancy.there should be a low threshold to biopsy... |
using radioimmunoassay , we first examined pacap peptide levels in peripheral blood samples from a previously described , highly traumatized , at risk population1113 that had been matched on age , sex , and trauma histories ( n = 64 , see suppl .
we found that ptsd symptoms ( ptsd symptom scale14 ) were significantly... | pituitary adenylate cyclase - activating polypeptide ( pacap ) is known to broadly regulate the cellular stress response .
in contrast , it is unclear if the pacap / pac1 receptor pathway has a role in human psychological stress responses , such as posttraumatic stress disorder ( ptsd ) . in heavily traumatized subje... |
preconception care is one of the main instruments of high - income countries to reduce stillbirth rates ( flenady et al .
, the dutch health council recommended to initiate preconception care by means of a central programme . since 2006 , a rapidly growing number of midwifery practices have started offering preconcep... | to date , little is known about the psychosocial aspects of preconception consultation ( pcc ) in primary care .
pcc in primary care is appropriate for couples and individuals with a reproductive wish . in pcc ,
non - genetic and genetic risk factors may be identified . focusing on non - genetic and genetic risk fa... |
liposarcomas are the second most common soft tissue sarcoma in adults after malignant fibrous histiocytoma , predominantly occurring in the lower extremity and the retroperitoneum .
it constitutes < 1% of all mediastinal malignancies and 9% of all primary mediastinal sarcomas with scarce data in the literature to dat... | this case describes the incidental finding and surgical removal of an 1.8-kg liposarcoma in the anterior mediastinum .
these tumors are very rare and would normally present with symptoms of intrathoracic compression ; however , this patient was completely asymptomatic .
the case presentation and treatment rationale... |
stress - induced cardiomyopathy ( also known as takotsubo cardiomyopathy or apical ballooning syndrome ) is characterized by acute , reversible and transient left ventricular ( lv ) systolic dysfunction that resembles acute coronary syndrome but does not show significant stenosis on coronary angiography.1)2 ) emotional... | echocardiography is widely used to carry out non - invasive cardiac evaluation at the bedside and provides useful real - time information about hemodynamics .
it can also be used to diagnose a stress - induced cardiomyopathy and its complications such as shock , heart failure and apical thrombus .
early diagnosis a... |
the long disputed issue of rehabilitation of extensor tendon repairs in zones v vii has been concerned with either complete immobilisation of these repairs[16 ] or mobilisation within the constraints of splint.[79 ] in recent times , most authors have preferred some form of mobilisation .
the regimens employed for t... | background : whether to splint the extensor tendon repairs or to mobilise them early is debatable .
recently , mobilisation has shown favourable results in a few studies .
this study was aimed to compare the two favoured protocols ( immobilisation vs. early active motion ) in indian population.patients and methods ... |
the diagnostic and therapeutic approach to multiple sclerosis ( ms ) has changed with the introduction of improved neuroimaging technology and disease - modifying medications . a decrease in the frequency and severity of relapses with a positive impact on overall functional abilities led to calls for earlier treatment ... | constipation and fecal incontinence are common in patients with neuromuscular diseases . despite their high prevalence and potential impact on overall quality of life
, few studies have addressed anorectal dysfunction in patients with multiple sclerosis ( ms ) .
the goal of this paper is to define the prevalence , ... |
breast implant insertion has evolved as a largely established and accepted modality for reconstruction after mastectomy , correction of congenital malformations and cosmetic augmentation of the breast .
the procedural volume of alloplastic breast implant reconstruction and augmentation is high , and it will further i... | backgroundthe first international breast ( implant ) conference was held by the eaos ( european academy of senology ) in cooperation with the german society of senology during its 29th annual meeting in dsseldorf , germany , on 13 june 2009.methodsit was performed as a whole - day interactive workshop in which the stan... |
cytomegalovirus(cmv ) infection is widely seen in humans , from new - born to adults , being ubiquitously present and causes subclinical disease , mostly primary cmv infection may result in a mononucleosis - like syndrome in adolescents and young adults .
cmv infection and disease occur with high frequency in immunoc... | cmv infection may occur anywhere in the gastrointestinal tract . among the small intestine
, ileum is the most common site of cmv disease and infection of jejunum is a rare one in patients with cmv gastroenteritis .
although rare , the reason why the recognition of this diagnosis is important is that it cause the l... |
microglia have been known to be present in the characteristic plaques of alzheimer disease since the first descriptions of these cells by del rio hortega and penfield in the 1920s , but half a century would pass before attention returned to these cells .
the first suggestion of a causative role for microglia in alzhe... | microglia have long been noted to be present and activated in alzheimer brain .
demonstrations that these microglia are associated with the specific lesions of alzheimer disease a plaques and neurofibrillary tangles and that these microglia overexpress the potent proinflammatory cytokine interleukin-1 led to the re... |
the current approach to the surgical management of patients with univentricular hearts is staged repair , which includes neonatal surgery to establish a source of controlled pulmonary blood flow and eliminate systemic outflow obstruction , followed successively by bidirectional superior cavopulmonary shunt ( bscps ) an... | extrinsic compression of airways is one the most important causes of respiratory insufficiency in the perioperative period in children with congenital heart disease .
this is especially true of pathologies that involve surgery of the aortic arch or conduit replacement of the right ventricular outflow tract .
howeve... |
pseudotumor cerebri or idiopathic intracranial hypertension is a known complication of morbid obesity that often requires neurosurgical intervention for worsening symptoms .
placement of a lumboperitoneal shunt ( lps ) is one of the treatment options , but in a morbidly obese patient it can be technically challenging... | background : pseudotumor cerebri or idiopathic intracranial hypertension is a known complication of morbid obesity that often requires neurosurgical intervention for worsening symptoms .
placement of a lumboperitoneal shunt ( lps ) is one of the treatment options , but in a morbidly obese patient it can be technicall... |
mental health problems such as depression , anxiety , and insomnia are among the most common reasons for individuals to seek treatment with complementary therapies , and yoga appears to be a promising intervention as it is cost - effective and easy to implement . according to the latest factsheet on depression from the... | aim and objectives : this study was undertaken to evaluate the effectiveness of yoga on the mental health status of elderly women inmates residing in a hospice in puducherry.materials and methods : forty elderly women were randomly divided into yoga and wait - listed control group . a yoga therapy program of 60 min was... |
on april 13 , 2000 , the pennsylvania state department of health notified the centers for disease control and prevention ( cdc ) of an increase in salmonella
enterica subspecies enterica serotype typhimurium .
active surveillance for salmonella group b and serotype typhimurium was initiated , and health officials i... | an outbreak of multidrug - resistant salmonella
enterica serotype typhimurium infections occurred in pennsylvania and new jersey . a case - control study implicated pasteurized milk from a dairy , and
an inspection indicated the potential for contamination after pasteurization .
dairy cattle are the likely reserv... |
o efeito antiplaca e antigengivite de um gel contendo extrato de rom a 10% foi avaliado utilizando um modelo de gengivite experimental parcial em humanos .
23 indivduos participaram voluntariamente deste estudo cruzado , duplo - cego , compreendendo dois perodos de 21 dias cada um .
uma moldeira de acrlico foi conf... | objectives : the antiplaque and antigingivitis effects of a gel containing 10% punica granatum linn extract were evaluated using a 21-day partial - mouth experimental model of gingivitis.methods:23 volunteers participated in this cross - over , doubleblind study , carried out in 2 phases of 21 days each . for each peri... |
ebbd 17.2 ( stappia indica ) :
https://www.ncbi.nlm.nih.gov/bioproject/328867 ebb 35.1 ( nitratireductor aquibiodomus ) :
https://www.ncbi.nlm.nih.gov/bioproject/prjna327597 sbbc 49 ( stappia indica ) :
https://www.ncbi.nlm.nih.gov/bioproject/prjna328866
coral reefs are one of the most diverse , yet vulnerable ... | we announce the draft genome sequence of three gram - negative bacteria isolated from coral tissues affected with the black band disease ( bbd ) , identified with the ncbi 's assembly database accession numbers : mbqf , mayb and mbqe .
these genome drafts constitute an useful tool for the characterisation of these ba... |
currently , feeding standards for ruminants are based on predictions of total digestible nutrients ( tdn ) , digestible energy ( de ) , metabolizable energy ( me ) , and/or net energy ( ne ) from the in vitro digestibility determinations of organic matter ( ivomd ) and/or chemical composition [ 13 ] . however , there a... | in in vitro true dry matter degradability ( ivtdmd ) , in situ dry matter degradability , and neutral detergent fiber degradability , both in vitro ( ivndfd ) and in situ ( isndfd ) techniques were used with crossbred goats to determine dry matter and neutral detergent fiber ( ndf ) ruminal degradability in eight forag... |
body
balance and lower limb muscular strength are common therapeutic targets to reduce the risk
of falls among community - dwelling older adults1,2,3 .
balance and strengthening exercises not only reduce the risk of falls and associated
injuries but can also improve overall body management , reduce physical imp... | [ purpose ] the aim of this study was to investigate the effects of ving tsun ( vt ) chinese
martial art training on radial bone strength , upper- and lower - limb muscular strength ,
shoulder joint mobility , balance performance , and self - efficacy in elderly participants .
[ subjects and methods ] twelve seni... |
chronic renal failure ( crf ) has emerged as an important public health problem with an increasing annual incidence ( 1 ) .
various treatment methods for this disease have increased patients life expectancy . however , due to the increase in life expectancy , the patients have encountered new problems that can have a... | introductionroutine hemodialysis is one of the preferred treatment methods in patients with chronic kidney disease .
it seems that routine hemodialysis can be effective in improving sexual function in these patients .
this study aimed to determine the effect of routine dialysis sessions over a six - month period on... |
antisense oligonucleotides ( asos ) bind to their cognate mrna by watson - crick base - pairing and modulate its processing to produce a pharmacological effect .
asos that function through the rnase h - based antisense mechanism were first discovered more than three decades ago when administration of exogenous short ... | antisense oligonucleotides ( asos ) have the potential to discriminate between subtle rna mismatches such as snps .
certain mismatches , however , allow asos to bind at physiological conditions and result in rna cleavage mediated by rnase h. we showed that replacing dna nucleotides in the gap region of an aso with o... |
estrogen receptors ( ers ) are nuclear transcription factors and hormone - regulated modulators of intracellular signaling and gene expression.14 there are two subtypes of ers , er- and er-. er- is encoded by the esr1 gene on chromosome 6 , and er- is encoded by the esr2 gene on chromosome 14.5 both er- and er- are wid... | backgroundestrogen receptors ( ers ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans .
ers have been validated as important drug targets for the treatment of various diseases , including breast cancer , ovarian cancer , osteoporosis , and cardiov... |
indwelling central venous catheters ( cvcs ) such as the broviac catheter ( bc ) offer reliable vascular access and are indispensable for long - term chemotherapy in cancer patients or patients undertaking long term parenteral nutrition .
possible complications include infection , thrombosis or mechanical pr... | background . mechanical complications in the use of indwelling central venous catheters ( cvcs ) such as the broviac catheter ( bc ) include kinking , occlusion , dislocation or leaking .
we report on a mechanical complication after using a repair kit for the bc
. method . a 4-year old boy , suffering from multiple... |
the short supply of donor pancreases prevents extensive clinical application of islet transplantation as a cure for diabetes [ 1 - 3 ] , which heightens the need for alternative sources of insulin - producing beta cells .
since mature beta cells have a very slow proliferation rate , which further declines with age [ ... | islet transplantation is an effective therapy for severe diabetes .
nevertheless , the short supply of donor pancreases constitutes a formidable obstacle to its extensive clinical application .
this shortage heightens the need for alternative sources of insulin - producing beta cells .
since mature beta cells hav... |
in many instances , hemodynamic optimization requires the use of fluids . however , the response to fluids may be quite variable and can not be adequately predicted from the measurements of intravascular pressures ( central venous pressure or pulmonary artery pressure ) or volumes .
dynamic indices reflecting respi... | predicting fluid responsiveness has become a topic of major interest . measurements of intravascular pressures and volumes often fail to predict the response to fluids , even though very low values are usually associated with a positive response to fluids .
dynamic indices reflecting respiratory - induced variations ... |
envenoming resulting from snake bites is an important public health hazard in many regions , particularly in tropical and subtropical countries [ 1 , 2 ] .
the saw - scaled viper echis ocellatus is the most abundant and medically important viper species in west africa .envenoming by saw - scaled viper ( viperidae :... | envenoming by echis saw - scaled viper is the leading cause of death and morbidity in africa due to snake bite . despite its medical importance
, there have been few investigations into the toxin composition of the venom of this viper . here , we report the cloning of cdna sequences encoding four groups or isoforms o... |
central serous chorioretinopathy ( csr ) is a well - established clinical entity known to occur in individuals with type a personality .
a 24-year - old man with left sided facial palsy was prescribed tablet prednisolone 60 mg per day for five days .
three days after initiation of prednisolone , the patient reporte... | a-24 year - old male was prescribed prednisolone ( 60 mg / day ) for left sided facial palsy . after three days of therapy ,
the patient complained of black spots in his vision in right eye .
fluorescein angiography of right eye showed evidence of central serous retinopathy ( csr ) .
prednisolone dose was withdra... |
leishmaniasis is a protozoan parasitic disease found in 16 developed and 72 developing countries with 12 million cases ; it causes around 70000 deaths annually .
various antileishmanial agents are readily available in the market although none of these chemotherapy drugs are free from harmful side effects and toxicity... | natural products have long been providing important drug leads for infectious diseases .
leishmaniasis is a major health problem worldwide that affects millions of people especially in the developing nations .
there is no immunoprophylaxis ( vaccination ) available for leishmania infections , and conventional treat... |
many endodontic literatures project maxillary lateral incisors as a tooth with a single root and single canal.[13 ] this may not be true in 100% of cases as case reports have advocated maxillary lateral incisors showing two roots with two or three root canals .
successful non - surgical endodontic management depends ... | variation in the roots and root canal anatomy seems to be the norm rather than an exception . for a successful endodontic treatment , a clinician should have a thorough knowledge of the internal and external dental anatomy and its variations .
maxillary lateral incisors usually exhibit single canal with a single root... |
adult patients admitted to undergo general elective or emergency surgery and not expected to require icu admission were eligible for inclusion .
we enrolled patients with a blood glucose ( bg ) level between 140 mg / dl and 400 mg / dl who had a history of diabetes for more than 3 months , aged 1880 years old , treat... | objectivethe optimal treatment of hyperglycemia in general surgical patients with type 2 diabetes mellitus is not known.research design and methodsthis randomized multicenter trial compared the safety and efficacy of a basal - bolus insulin regimen with glargine once daily and glulisine before meals ( n = 104 ) to slid... |
it is comprised of nonfunctioning primitive lung tissue , having no communication with the tracheobronchial tree , and contains a systemic arterial supply .
pulmonary sequestration has been found to be associated with other congenital anomalies like congenital diaphragmatic hernia , congenital heart diseases , and ga... | pulmonary sequestration cyst is a rare entity in pediatric patients .
most of the time , it is diagnosed as an incidental finding .
it is associated with other congenital anomalies , especially congenital diaphragmatic hernia .
we report a patient of cerebral palsy presented with vomiting and recurrent chest infe... |
glutathione transferases ( gsts ) represent a major cellular defence system ; they constitute a multigene family divided in seven families ( alpha , mu , pi , theta , sigma , zeta , and omega ) with functions ranging from detoxification to biosynthesis and cell signaling [ 1 , 2 ] .
the most extensively investigated ... | glutathione transferases ( gst ) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens , environmental pollutants , and antitumor agents .
however , this protein family is also involved in the metabolism of endogenous compounds wh... |
an 18-year - old woman was referred for the evaluation of right - side pleural thickening found on a chest x - ray during a medical checkup at school .
she and her family were unaware of any previous history of a mass and denied any history of trauma , infection , or tuberculosis . on physical examination , it was di... | nodular fasciitis is a benign reactive proliferation that usually involves the deep fascia .
although it is relatively common in the adult population , it is often misdiagnosed as sarcoma due to its rapid growth and pathological features .
it rarely presents as a chest wall tumor in young patients . here , we repor... |
the objective of laceration repair or incision closure is to approximate the edges of a wound so that natural healing process may occur . to promote healing one should achieve precise wound approximation , reduction of patient discomfort , easy handling of the working properties of wound closure materials , and low inf... | wound closure is a part of any surgical procedure and the objective of laceration repair or incision closure is to approximate the edges of a wound so that natural healing process may occur . over the years
new biomaterials have been discovered as an alternate to conventional suture materials .
cyanoacrylate bioadh... |
this clinic has been set up in a multispecialty tertiary care hospital in south india that already has a specialized unit for developmental pediatrics , pediatric neurology , and pediatric psychiatry .
the author underwent specialized cvi vision assessment training abroad . the training involved vision assessment and... | aim : the aim of this study is to describe the setting up of a cerebral visual impairment ( cvi ) clinic in a tertiary care hospital in south india and to describe the spectrum of cases seen.materials and methods : the cvi clinic , set up in february 2011 , receives interdisciplinary input from a core team involving a ... |
study population - in the present study , serum samples from 215
paediatric patients were tested by molecular analysis to confirm the diagnosis of
clinical hepatitis due to hbv infection .
we previously reported the serological profile
of these patients , who were admitted to the paediatric infectious disease d... | studies on the prevalence of infection with hepatitis b virus ( hbv ) among children
are scarce in latin american countries , especially in mexico .
this study was aimed to
investigate the prevalence of hbv infection , occult hepatitis b infection ( obi ) and
hbv genotypes among children with clinical hepatitis... |
alzheimer s disease ( ad ) , a progressive neurodegenerative disorder , accounts for up to 75% of all dementia cases.1 worldwide , more than 35 million people live with ad , and this number is expected to double by 2030 and reach 115 million by 2050.2 the progression of symptoms in patients with ad can be delayed by ea... | purposerivastigmine transdermal patch has shown higher caregiver satisfaction and greater preference than oral formulation in patients with alzheimer s disease .
however , there is limited literature available related to caregiver preference or treatment compliance in real - world clinical settings . to date
, no s... |
this analysis used data from the 20062010 and 20112013 nsfg , a continuous national probability household survey of women and men aged 1544 years in the united states ( http://www.cdc.gov/nchs/nsfg.htm ) . the surveys used a multistage , stratified clustered sampling frame to collect interviews continuously from june 2... | purposeupdated estimates of adolescents receipt of sex education are needed to monitor changing access to information.methodsusing nationally representative data from the 20062010 and 20112013 national survey of family growth , we estimated changes over time in adolescents receipt of sex education from formal sources a... |
most cases were reported around the turn of the century . a literature review conducted in 1998 noted 256 reported cases of ingested foreign bodies within the appendix occurring over the last 100 years . since that review , only 2 cases have been reported .
lead shot or pellets retained in the appendix after ingestio... | we describe a patient presenting with lead shot in his appendix .
a plain radiograph of his lumbar spine was performed for back pain , and an incidental finding of lead shot retained within the appendix was seen .
lead shot in the appendix is associated with appendicitis , and 2 cases have been reported of lead int... |
we establish a computational approach
to extract the bending modulus , kc , for lipid membranes from relatively small - scale molecular
simulations .
fluctuations in the splay of individual pairs of lipids
faithfully inform on kc in multicomponent membranes over a large range of rigidities in
different thermo... | |
primary myelofibrosis ( pmf ) is a rare chronic myeloproliferative disorder that usually involves the bone marrow with proliferation of megakaryocytes and granulocytic elements and has a variable degree of marrow fibrosis ( 1 ) . when the marrow is fibrotic , there is usually myeloid metaplasia or extramedullary hemato... | a case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [ del ( 18 ) ( p11.2 - 3 ) ] is reported .
the abnormalities are identical among specimens from the lymph node , peripheral blood , and bone marrow that were analyzed years apart .
additionally , we show that the infiltrat... |
dermoscopic features were reported in only one of them and not one described reflectance confocal microscopy ( rcm ) features .
a 7 5 mm slight brown - gray pigmented pedunculated lesion was detected on the right post - auricular region on the routine skin examination of a 60-year - old woman .
she had a history... | there have been limited cases of pedunculated basal cell carcinoma ( bcc ) reported in the literature .
the dermoscopic features were described in only one of them . however , not one of them described the confocal microscopy features . in this report we presented a case of pedunculated basal cell carcinoma ( bcc ) w... |
atrazine ( 2chloro4ethylamino6isopropylamino1,3,5triazine ) is an effective herbicide used worldwide for broadleaf weed control . because of its high mobility in soil and its massive application ,
atrazine has often been detected in surface and ground waters at concentrations well above the legal limits ( kolpin and ... | summaryatrazine is an herbicide of the striazine family that is used primarily as a nitrogen source by degrading microorganisms .
while many catabolic pathways for xenobiotics are subjected to catabolic repression by preferential carbon sources , atrazine utilization is repressed in the presence of preferential nitro... |
schizophrenia is a severe and chronic mental illness with a complex clinical presentation suggesting an etiologic and genetic heterogeneity that could benefit from the definition of particular phenotypes using quantitative heritable components .
a recent dopamine hypothesis of schizophrenia suggests a final common pa... | given that schizophrenia is a heterogeneous disorder , the analysis of clinical characteristics could help to identify homogeneous phenotypes that may be of relevance in genetic studies .
linkage and association studies have suggested that a locus predisposing to schizophrenia may reside within xp11 .
we analyzed u... |
interstitial cystitis / painful bladder syndrome ( ic / pbs ) is a chronic pathological condition of the bladder characterized by symptoms such as pelvic pain , urgency or frequency in urination , and suprapubic discomfort .
ic / pbs inevitably influences normal physical and mental health and presents a remarkable ne... | prokineticin 2 ( pk2 ) is a novel chemokine - like peptide with multiple proinflammatory and nociception - related activities .
this study aimed to explore the potential role of pk2 in modulating bladder activity and sensation in rats with cyclophosphamide- ( cyp- ) induced cystitis .
changes of pk2 and prokinetici... |
multiple sclerosis ( ms ) is the most common progressive neurological disease among younger adults , with approximately 17000 people diagnosed in sweden in 2011 and an estimated 2.5 million people with ms ( pwms ) worldwide .
more women than men are diagnosed as having ms ; the ratio is at least 2 : 1 .
imbalan... | objective . to evaluate the validity of the activities - specific balance confidence scale ( abc ) in people with multiple sclerosis ( pwms )
. design .
a multicentre , cross - sectional study . setting .
six rural and urban swedish sites , including specialized units at hospitals and primary care centers . parti... |
relevant english - language articles were identified by searching the medline database ( national library of medicine , bethesda , md ) from 1966 to may 2010 for prospective cohort studies of intake of ssbs ( soft drinks , carbonated soft drinks , fruitades , fruit drinks , sports drinks , energy and vitamin water drin... | objectiveconsumption of sugar - sweetened beverages ( ssbs ) , which include soft drinks , fruit drinks , iced tea , and energy and vitamin water drinks has risen across the globe .
regular consumption of ssbs has been associated with weight gain and risk of overweight and obesity , but the role of ssbs in the develo... |
ideal treatment for cerebral aneurysm is to decrease its mass effect , and maintain the integrity of normal vasculature .
it is achieved by surgical clipping across the aneurysm neck or endovascular coil embolization to preserve the parent vessels.17)18)22)26 ) the above mentioned procedures can be performed in the m... | objectiveaccording to the development of endovascular technique and devices , larger aneurysms on the distal internal carotid artery ( ica ) can be treated using a less invasive method .
the authors report on clinical and angiographic outcomes of these aneurysms treated using an endovascular technique.materials and m... |
malaria continues to be a worldwide burden despite global efforts to curb the disease . in ghana
, malaria is one of the main causes of adult morbidity and the leading cause of workdays loss to illness .
malaria also accounts for 44% of outpatient attendance , 13% of all hospital deaths , and 22% of mortality among... | differences in quality performance score had been reported for the routinely used diagnostic methods for malaria at different settings .
there is therefore a need to evaluate the test performance of the routine diagnostic methods for malaria detection in ho , a setting with no recorded quality evaluation on malaria d... |
from july 2006 to november 2007 , a population - based study on glucose tolerance was performed in the city of hoorn , the netherlands ( the new hoorn study ) .
a random sample of 6,180 men and women aged 4065 years was drawn from the municipal population registry of hoorn . following dutch privacy legislation
, al... | objectiveto investigate the relationship among a1c , fasting plasma glucose ( fpg ) , and 2-h postload plasma glucose in the dutch general population and to evaluate the results of using a1c for screening and diagnosis of diabetes.research design and methodsin 20062007 , 2,753 participants of the new hoorn study , aged... |
we performed a comprehensive retrospective review of the medical records of patients who were pathologically confirmed between 1996 and 2011 ( n = 19 ) , and we performed an investigation of image tests such as simple x - rays , angiographies , contrast - enhanced cts and magnetic resonance images ( mris ) , as well as... | backgroundalveolar soft part sarcoma ( asps ) is a rare soft tissue tumor that usually affects young patients . because of the rarity of the disease ,
most reports relating to asps are in the form of case reports or small series.methodswe performed a retrospective study to evaluate the clinicopathologic features , tr... |
a patient mutation in the final amino acid of the pde6 subunit provides clinical evidence of the importance of differential pde6 lipid modifications . based on studies of prenyltransferase
caax box specificity , the mutation is predicted to alter the prenyl group from a geranylgeranyl to a farnesyl group .
the pat... | daily phagocytosis of outer segments ( os ) places extraordinary demands on protein biosynthesis and trafficking in photoreceptor neurons .
while the members and roles of the phototransduction pathway in the os are well characterized , details about protein trafficking are just beginning to emerge .
phosphodiestera... |
malignant pleural mesothelioma ( mpm ) was once a rare finding , but patients with asbestos - related mesothelioma have increased in numbers over the last few decades . a pathological diagnosis of mpm can not be made by close medical examination in some cases , and it is one of the diseases that are difficult to diagno... | the patient experienced chest pain for about 7 months , but a diagnosis could not be made until after death .
he was diagnosed with malignant sarcomatoid pleural mesothelioma on autopsy . in this case report
, difficult aspects of the diagnosis are discussed .
the 70-year - old japanese man was a driver who trans... |
the icare ta01i ( icare finland oy , helsinki , finland ) rebound tonometer is a relatively recent addition to the portfolio of tonometers currently available to the ophthalmic practitioner for measuring intraocular pressure ( iop ) .
hitherto , studies have shown that the rebound tonometer performs adequately as a s... | purpose . to examine the influence of positional misalignments on intraocular pressure ( iop ) measurement with a rebound tonometer
. methods . using the icare
rebound tonometer , iop readings were taken from the right eye of 36 healthy subjects at the central corneal apex ( cc ) and compared to iop measures using ... |
the study protocol was approved by the institutional review board of ewha womans university mokdong hospital ( irb no . 2016 - 07 - 060 ) .
she manifested blurred vision in both eyes severe enough not to be able to distinguish objects , hypomimia , hypophonia , monotonous and slurred speech , bradykinesia , and trunc... | methanol poisoning results in neurological complications including visual disturbances , bilateral putaminal hemorrhagic necrosis , parkinsonism , cerebral edema , coma , or seizures .
almost all reported cases of methanol poisoning are caused by oral ingestion of methanol .
however , recently there was an outbreak... |
data consisted of videos of clinical visits obtained from both study arms of a randomized trial ( 1 ) of a decision aid to help choose antihyperglycemic agents ( including insulin ) , versus usual care , among 85 adults with type 2 diabetes recruited from 11 primary care sites in minnesota .
eligible patients had dia... | objectivepatients with diabetes may experience high burden of treatment ( bot ) , including treatment - related effects and self - care demands .
we examined whether patients with type 2 diabetes and their clinicians discuss bot , the characteristics of their discussions , and their attempts to address bot during vis... |
scoliosis is a complex deformity of spine characterised by lateralisation of spinal curvature with malrotation of vertebrae and mainly affects cardiovascular , respiratory and nervous systems .
we present the anaesthetic management of a child who underwent scoliosis reconstruction with a rare triad of cerebral palsy ... | scoliosis may be of varied aetiology and may be associated with severe congenital anomalies .
it often poses a challenge in its anaesthetic management .
we present anaesthetic management of a child who underwent scoliosis reconstruction with a rare triad of cerebral palsy , glucose-6-phosphate dehydrogenase deficie... |
plaque psoriasis is a chronic , recurring condition that varies in severity and body surface area ( bsa ) affected .
it can manifest from few localized areas to complete body coverage , and can also primarily involve the hands and feet , including nails . of the 13% of the general population who have psoriasis ,
an... | backgroundthe randomized controlled evaluation of adalimumab in treatment of chronic plaque psoriasis of the hands and feet ( reach ) trial demonstrated that adalimumab was efficacious and well - tolerated for the treatment of hand and/or foot psoriasis through 28 weeks.objectiveto evaluate the effects of patient basel... |
the surface of a protein is the region where the protein interacts with other molecules such as other proteins , nucleic acids , membrane receptors and small ligands .
the electrostatic potential is a fundamental property of the protein surface , playing a central role in recognition of other macromolecules ( 1 ) .
... | positively charged electrostatic patches on protein surfaces are usually indicative of nucleic acid binding interfaces .
interestingly , many proteins which are not involved in nucleic acid binding possess large positive patches on their surface as well . in some cases ,
the positive patches on the protein are rela... |
in this work , a meoh - d4 solution of a and 1 was first exposed to 3 bar para - h2 ,
to form [ ir(h)2(imes)(mecn)3]cl , 2 . when this reaction was completed in a magnetic
field ( referred to as the polarization transfer field or ptf ) of 65
g ,
the resulting h nmr signal for free acetonitrile was
observed 3 ... | we report on a strategy for using
sabre ( signal amplification by
reversible exchange ) for polarizing 1h and 13c nuclei of weakly interacting ligands which possess biologically
relevant and nonaromatic motifs .
we first demonstrate this via the
polarization of acetonitrile , using ir(imes)(cod)cl as the cata... |
this is a physiological process and thought to arise from the pressure of erupting teeth . in contrast , root resorption in permanent teeth is infrequent and pathological .
pathological root resorption is related to several local and systemic factors . by definition , if an etiological factor can not be identified fo... | multiple idiopathic external apical root resorption ( miearr ) is a relatively rare condition affecting multiple teeth in a dentition .
as the condition is nonsymptomatic , a case is usually detected as an incidental radiographic finding .
however , it may cause pain and mobility in severe cases .
it is sometimes... |
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