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8,700 | 7,696 | The dichotomous distribution of gastrinomas.
Our experience with 47 sporadic gastrinomas suggests that no less than 85% of these tumors are located to the right of the superior mesenteric artery.
This finding is unexpected because approximately 75% of insulinomas and glucagonomas are located to the left of the superi... | C04 |
8,701 | 3,789 | Malignant potential of juvenile polyposis coli. Report of a case and review of the literature.
Juvenile polyps of the colon and rectum traditionally have been viewed as being benign inflammatory or harmartomatous lesions without potential for malignant change.
The authors report a case of adenocarcinoma developing in... | C04 |
8,702 | 4,220 | Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues.
PTH-like peptide (PLP) is produced by tumors commonly associated with hypercalcemia as well as nonneoplastic tissues and several endocrine glands and tumors.
To characterize the distribution of PLP in human endocrine tissues and tumors... | C04 |
8,703 | 80 | Distinct characteristics of lymphokine-activated killer (LAK) cells derived from patients with B-cell chronic lymphocytic leukemia (B-CLL). A factor in B-CLL serum promotes natural killer cell-like LAK cell growth.
We show that lymphokine-activated killer (LAK) cell precursors derived from patients with B-cell chronic... | C04 |
8,704 | 5,553 | Vitreous changes and macular edema in central retinal vein occlusion.
The condition of the posterior vitreous was determined in 56 eyes with central retinal vein occlusion (CRVO).
Using a life-table analysis, it was studied in 56 eyes.
The incidence of posterior vitreous detachment (PVD) in the CRVO eyes at the firs... | C04 |
8,705 | 3,788 | Colonic lipoma as a source of massive hemorrhage. Report of a case.
Colonic lipomas are a rare source of massive lower gastrointestinal bleeding requiring operative intervention.
A case of massive hemorrhage from cecal lipomatosis is presented.
The methods of preoperative diagnosis and treatment are discussed. | C04 |
8,706 | 8,942 | Segregation analysis of breast cancer from the cancer and steroid hormone study: histologic subtypes
The segregation pattern of breast cancer in white families from the Cancer and Steroid Hormone Study was investigated.
Families were categorized into four groups based on the histologic type of breast cancer in the p... | C04 |
8,707 | 7,153 | Clinical management of port-wine stain in infants and young children using the flashlamp-pulsed dye laser.
The flashlamp-pulsed dye laser (FLPDL) at 585 nm, a wavelength well absorbed by oxyhemoglobin, causes highly selective vascular injury.
In addition, the 450 microsecond pulse duration produced by this laser appr... | C04 |
8,708 | 2,106 | Male breast cancer.
Male breast cancer is uncommon but important.
The diagnosis is easily made by breast biopsy, and patients are presenting earlier in the course of the disease than in the past.
Despite this, patients are often first seen with tumors that have metastasized to the axillary nodes, which markedly decr... | C04 |
8,709 | 8,485 | Extraadrenal retroperitoneal paragangliomas: natural history and response to treatment.
Extraadrenal retroperitoneal paragangliomas (RP) are uncommon tumors.
Because of their rarity, little is known of their natural history or response to treatment.
We reviewed 22 patients with RP who were seen at our center between... | C04 |
8,710 | 7,767 | Combined modality therapy for locally advanced non-small cell lung carcinoma.
Multi-modality treatment consisting of cisplatin, VP-16, and 5-fluorouracil chemotherapy given concomitantly with external beam radiation was used to treat 64 patients with locally advanced Stage III non-small cell lung carcinoma.
This regi... | C04 |
8,711 | 4,351 | Severe lidocaine intoxication by cutaneous absorption.
A severe lidocaine intoxication by cutaneous absorption is described.
Data are presented to show a significant absorption of lidocaine through diseased skin when lidocaine cream is used as a local anesthetic.
Awareness of this route of intoxication might be impo... | C04 |
8,712 | 9,747 | Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor.
Expression of insulin-like growth factor I (IGF-I) mRNA by some tumor cell lines of neuroectodermal origin has been described.
To further explore the significan... | C04 |
8,713 | 7,157 | Predictive value of congenital hypertrophy of the retinal pigment epithelium as a clinical marker for familial adenomatous polyposis.
One hundred forty-eight members of 53 kindreds with familial adenomatous polyposis (FAP) were examined for congenital hypertrophy of the retinal pigment epithelium (CHRPE) and extracolo... | C04 |
8,714 | 2,397 | A diagnostic expert system for colonic lesions.
The diagnostic expert system for colonic lesions (DESCL) was designed to discriminate colonic adenoma and adenocarcinoma from normal colonic tissue.
Although it was originally developed for use in conjunction with a machine vision analytic system, the DESCL has evolved ... | C04 |
8,715 | 7,054 | The in vivo biologic effect of interleukin 2 and interferon alfa on natural immunity in patients with head and neck cancer.
Given the association of deficient natural immunity with the risk of metastatic disease, the ability to activate natural killer cell function may have a therapeutic significance.
The effect of c... | C04 |
8,716 | 6,296 | Follicular neoplasms of the thyroid in men older than 50 years of age. A DNA flow cytometric study
The clinical behavior of follicular neoplasms of the thyroid in elderly men can be difficult to predict on histologic grounds alone.
To assess the usefulness of DNA flow cytometry in predicting the metastatic potential... | C04 |
8,717 | 7,789 | Disseminated strongyloidiasis with central nervous system involvement diagnosed antemortem in a patient with acquired immunodeficiency syndrome and Burkitts lymphoma.
A 45-year-old man presented with central nervous system involvement as the initial manifestation of disseminated infection with Strongyloides stercorali... | C04 |
8,718 | 3,379 | Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy.
Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia.
Thymic carcinomas may metastasize outs... | C04 |
8,719 | 5,082 | Adverse impact of fibrin clot inhibitors on intravesical bacillus Calmette-Guerin therapy for superficial bladder tumors.
Although intravesical bacillus Calmette-Guerin therapy has proved to be efficacious in the treatment and prophylaxis against tumor recurrence of superficial bladder tumors, its mechanism of action ... | C04 |
8,720 | 9,904 | Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo.
Inhibitors of glycoprotein processing, such as castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine), have been shown previously to inhibit human immunodeficiency virus type 1 (HIV-1) with acceptable ... | C04 |
8,721 | 9,243 | Glucagonoma syndrome is an underdiagnosed clinical entity.
Glucagonomas, considered among the rarest of the islet cell neoplasms, produce a well-defined clinical syndrome characterized by necrolytic migratory erythema, diabetes mellitus, glossitis, anemia, and weight loss.
This report describes seven patients with gl... | C04 |
8,722 | 8,671 | Surgical strategy in thyroid disease.
Over the past 8 years, 311 patients have undergone surgical treatment by the senior authors for thyroid disease.
Over 80% of the cases were performed by the head and neck surgical service at Olive View County Hospital, Sylmar, Calif, with the remainder performed at UCLA-affiliate... | C04 |
8,723 | 8,312 | Common nonvenereal genital lesions.
There are a wide variety of local and systemic skin diseases that produce lesions in the genitoanal region.
These lesions may resemble those produced by sexually transmitted microorganisms.
The purpose of this article is to make physicians aware of the common skin diseases that pr... | C04 |
8,724 | 3,778 | Colonoscopic screening of asymptomatic patients with a family history of colon cancer.
The records of 201 asymptomatic patients who underwent colonoscopy based solely on a family history of colon cancer were reviewed.
Eighty-five patients (42 percent) had a total of 166 lesions.
Fifty-four (27 percent) patients of t... | C04 |
8,725 | 7,994 | Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma.
Severe gastrointestinal dysmotility is a newly recognized paraneoplastic syndrome that occurs with small-cell lung carcinoma.
Thirty-four patients with small-cell carcinoma, of whom 5 had chronic intestinal pseudoobstruction and 29 h... | C04 |
8,726 | 6,845 | Strategy for lymphadenectomy in lung cancer three centimeters or less in diameter
We have surgically treated 221 patients with a primary lung cancer 3.0 cm or less in diameter.
There were 8 patients with a tumor 1.0 cm or less in diameter (group A), 84 with a tumor 1.1 to 2.0 cm in diameter (group B), and 129 with a... | C04 |
8,727 | 5,758 | A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.
Recently we molecularly cloned and characterized a papillomavirus from a lymph node metastasis of a primary penile carcinoma found in a rhesus monkey; this virus species, rhesus papillomavirus type 1 (RhPV-1), is... | C04 |
8,728 | 5,246 | Paraneoplastic cerebellar degeneration: a clinical comparison of patients with and without Purkinje cell cytoplasmic antibodies.
In a review of 32 patients with paraneoplastic cerebellar degeneration (PCD), 16 (all of whom were women) had Purkinje cell cytoplasmic antibodies (PCAb) and 16 (8 women) did not.
Most pati... | C04 |
8,729 | 218 | Immunophenotypes in "classical" B-cell chronic lymphocytic leukemia. Correlation with normal cellular counterpart and clinical findings.
This study evaluates the expression of a series of membrane antigens, normally expressed by B-lymphocytes of the lymphocytic mantle and marginal zone, in 90 selected cases of "classi... | C04 |
8,730 | 2,525 | The effect of large uterine fibroids on urinary bladder function and symptoms.
Fourteen patients with large uterine fibroids and urinary symptoms were treated with monthly injections of [D-Trp6]-luteinizing hormone-releasing hormone microcapsules.
The average uterine size before treatment was 728 ml; it dropped to 32... | C04 |
8,731 | 201 | Analysis of bladder carcinoma by subsite. Cystoscopic location may have prognostic value.
Nine hundred fourteen cases of carcinoma of the urinary bladder registered from 1977 to 1988 with the Kansas state tumor registry were evaluated by subsite for differences in grade, histology, sex, age at diagnosis, and survival.... | C04 |
8,732 | 6,011 | Synchronous Hodgkin's disease and myelofibrosis terminating with granulocytic sarcoma and acute megakaryocytic leukemia.
Our patient had stage IIIAI Hodgkin's disease with synchronous myelofibrosis and myeloid metaplasia.
A slowly progressive myeloproliferative disease developed over 9 1/2 years and terminated in a p... | C04 |
8,733 | 9,244 | Perioperative blood transfusion adversely affects prognosis of patients with stage I non-small-cell lung cancer.
It has been speculated that blood transfusion might adversely affect prognosis in cancer patients by immunosuppression.
To avoid the confounding affect of advanced disease, we tested this hypothesis in 117... | C04 |
8,734 | 3,294 | Autologous bone marrow transplantation in multiple myeloma: identification of prognostic factors.
Multiple myeloma remains a universally fatal malignancy with a median survival time not exceeding 3 years.
A clinical trial was undertaken to determine feasibility and efficacy of marrow-ablative chemoradiotherapy suppor... | C04 |
8,735 | 6,761 | The internist in the management of head and neck cancer.
The general internist has an important role in the management of head and neck squamous cell cancers.
This heterogeneous group of cancers must be accurately diagnosed and staged before planning treatment.
Curability is directly related to stage at presentation... | C04 |
8,736 | 4,805 | Questionable role of CNS radioprophylaxis in the therapeutic management of childhood rhabdomyosarcoma with meningeal extension.
A series of 15 consecutive children with head and neck nonorbital rhabdomyosarcoma (RMSA) with meningeal extension were prospectively treated with chemotherapy consisting of Adriamycin (doxor... | C04 |
8,737 | 3,389 | An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma.
The altered expression of the human retinoblastoma (RB) gene has been demonstrated to play an important role in the pathogenesis of RB and other tumors.
To determine whether the RB gene might be involved in the pathoge... | C04 |
8,738 | 546 | Strong association between diabetes and displacement of mouse anti-rat insulinoma cell monoclonal antibody by human serum in vitro.
In an attempt to identify novel pancreatic beta-cell surface antigens, mouse monoclonal antibodies (MoAbs) were raised against rat insulinoma (RIN5F) cells with standard techniques.
Seve... | C04 |
8,739 | 3,777 | A critical review of chemical lymph node clearance and staging of colon and rectal cancer at Ferguson Hospital, 1977 to 1982
A unique opportunity to evaluate the method of chemical lymph node clearance for colorectal cancer exists at Ferguson Hospital.
Lymph node clearance has been used at the institution since 1977... | C04 |
8,740 | 4,192 | Efficacy of transesophageal echocardiography as a perioperative monitor in patients undergoing cardiovascular surgery. Analysis of 149 consecutive studies.
To evaluate the usefulness of transesophageal echocardiography as a perioperative monitor in patients undergoing cardiovascular surgery, 149 consecutive patients w... | C04 |
8,741 | 2,654 | Reconstruction of mandibular defects in irradiated patients.
In this prospective study, mandibular reconstruction using titanium plates was evaluated in 31 patients treated between July 1988 and January 1990.
Sixteen patients had prior surgery; 13 had prior radiotherapy.
In 11 patients, prior radiation and surgery h... | C04 |
8,742 | 7,676 | Lymphomatoid granulomatosis presenting as ulcerodestructive gastrointestinal tract lesions in patients with human immunodeficiency virus infection. A new association.
We describe cases of severe odynophagia, extensive oral ulcerations, and bowel perforation in patients with human immunodeficiency virus infection that ... | C04 |
8,743 | 6,021 | Adenocarcinoma of the appendiceal stump.
We have reported the case of a 58-year-old woman with nonspecific abdominal complaints in whom barium enema and subsequent colonoscopy showed a 3 cm lobulated adenocarcinoma within a villous adenoma arising from the appendiceal stump.
Because such appendiceal malignancies have... | C04 |
8,744 | 2,595 | An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue.
Glutathione S-transferases (GSTs), a family of isoenzymes that play an important role in protecting cells from cytotoxic and carcinogenic agents, can be separated by biochemical and immunologic characteristics into th... | C04 |
8,745 | 2,032 | Protection from chemotherapy-induced alopecia in a rat model.
Alopecia (hair loss) is among the most distressing side effects of cancer chemotherapy.
Little progress has been made, however, in its prevention or treatment, partly because of the lack of suitable experimental model.
In recent work on the treatment of m... | C04 |
8,746 | 4,218 | Substance-P is present in a subset of thyrotrophs in the human pituitary.
Substance-P immunoreactivity and tachykinin-like peptides are present in the pituitary gland of several mammalian species.
In humans, however, the biochemical nature and cellular localization of pituitary substance-P has not been defined.
We r... | C04 |
8,747 | 230 | Immunocytochemical characterization of lung tumors in fine-needle aspiration. The use of cytokeratin monoclonal antibodies for the differential diagnosis of squamous cell carcinoma and adenocarcinoma.
In the current study, immunocytochemical typing of intermediate filaments was used for a differential diagnosis of hum... | C04 |
8,748 | 680 | Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis.
We prospectively monitored 140 cirrhotic patients for the development of hepatocellular carcinoma for 6 yr, using periodical screening by high-resolution convex-array ultrasonography and alpha-fetoprotein.
Twenty-eight patien... | C04 |
8,749 | 8,802 | Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks.
This investigation examined the correlation between Helicobacter pylori (HP) infection, as reflected in immunoglobulin G serum antibodies, and the risk of gastric cancer.
Serum samples were obtained from... | C04 |
8,750 | 2,444 | Hepatic giant cavernous hemangioma with microangiopathic hemolytic anemia and consumption coagulopathy.
We describe a case of hepatic giant cavernous hemangioma with both microangiopathic hemolytic anemia (MAHA) and consumption coagulopathy, but without thrombocytopenia, which was completely cured by surgical resectio... | C04 |
8,751 | 4,742 | Causes of death in hospitalized intravenous drug abusers.
The authors reviewed at autopsy the causes of death of 274 patients with evidence of intravenous drug abuse who had been admitted to a large public hospital.
There were 127 who died from diseases unrelated to intravenous drug abuse, and in 41% of these, chroni... | C04 |
8,752 | 3,332 | Persistent carcinoma in situ of the testis after chemotherapy for advanced testicular germ cell tumours.
The chemosensitivity of testicular carcinoma in situ (CIS) was analysed in 25 testes excised 10 weeks to 4.5 years following platinum-based chemotherapy.
CIS was present in 8 of the 23 evaluable cases (35%), in 5 ... | C04 |
8,753 | 84 | Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus.
Centrocytic lymphomas are defined in the Kiel classification as B-cell lymphomas composed exclusively of cells resembling cleaved follicular center cells (FCC).
These lymphomas have been shown to be histologic... | C04 |
8,754 | 7,426 | 585 nm for the treatment of port-wine stains.
Although the flashlamp-pulsed-dye laser has been successfully used for the treatment of port-wine stains (PWS) at 577 nm, a number of adult patients had incomplete clearance of their birthmarks with this treatment modality because of residual vessels lying beyond the 0.75-... | C04 |
8,755 | 3,431 | Cerebral tumor staging in patients with bronchial carcinoma by computed tomography.
Computerized tomographic (CT) scans of 271 patients with histologically proven bronchial carcinoma accomplished for initial tumor staging were retrospectively evaluated for signs of cerebral metastasis.
The results for the histologic ... | C04 |
8,756 | 8,479 | Time to recovery of the hypothalamic-pituitary-adrenal axis after curative resection of adrenal tumors in patients with Cushing's syndrome.
The recovery time of the hypothalamic-pituitary-adrenal (HPA) axis after curative resection of adrenal tumors in patients with Cushing's syndrome is poorly documented.
Eight cons... | C04 |
8,757 | 8,673 | Unknown primary squamous cell carcinoma metastatic to the neck.
We analyzed retrospectively 157 cases of metastatic neck squamous cell carcinoma from unknown primary sites, treated with surgery, radiotherapy, excisional biopsy, and combined modalities.
Median follow-up was 74 months, and overall actuarial survival wa... | C04 |
8,758 | 224 | Lewis system alterations in gastric carcinogenesis.
Alterations in the expression of type 1 blood group-related antigens (Lewis a and b) were examined immunohistochemically in 371 consecutives gastric biopsy and 80 surgical specimens from patients of gastric carcinoma.
The ABH and Lewis phenotype and secretor status ... | C04 |
8,759 | 7,484 | Widespread inflammatory response to osteoblastoma: the flare phenomenon.
A case of vertebral osteoblastoma caused a diffuse, reactive inflammatory infiltrate in two vertebrae, adjacent ribs, and the paraspinous soft tissues.
The authors call this the flare phenomenon.
On magnetic resonance images the diffuse inflamm... | C04 |
8,760 | 83 | Expression of transcobalamin II receptors by human leukemia K562 and HL-60 cells.
Plasma membrane receptors for the serum cobalamin-binding protein transcobalamin II (TCII) were identified on human leukemia K562 and HL-60 cells using immunoaffinity-purified human TCII labeled with [57Co]cyanocobalamin.
The Bmax value... | C04 |
8,761 | 5,109 | Transrectal ultrasonography in the evaluation of the infertile man: a report of 3 cases.
The traditional evaluation of the infertile man with azoospermia or low ejaculate volume includes determination of serum testosterone and follicle-stimulating hormone levels, a seminal fructose test, post-ejaculate urinalysis and,... | C04 |
8,762 | 6,890 | Long-term results of operation for non-small cell lung cancer in the elderly.
We surgically treated 185 patients with non-small cell lung cancer who were 70 years old or older.
The operative mortality rate was 3%, and the 5-year survival rate was 48%.
The mortality and prognosis were similar to those in younger pati... | C04 |
8,763 | 4,854 | Imaging of tumor in patients with indium-111-labeled biotin and streptavidin-conjugated antibodies: preliminary communication
Tumor localization in patients has been achieved through the in vivo use of streptavidin and biotin.
In these preliminary studies, the monoclonal antibody HMFG1 was conjugated with streptavid... | C04 |
8,764 | 9,179 | Multifocal gastric carcinoma arising from hyperplastic and adenomatous polyps.
This paper is a presentation of the unusual case of a 61-yr-old woman operated on for multiple gastric cancers.
Two of the cancers were found in the hyperplastic polyps and one in the adenoma.
Apart from cancers that arose from these poly... | C04 |
8,765 | 5,396 | Overall mortality and cancer mortality around French nuclear sites
Higher than expected mortality from leukaemia has been observed in the population under age 25 living around Sellafield and Dounreay, nuclear reprocessing plants in the United Kingdom.
We report the results of a similar study for the population resid... | C04 |
8,766 | 583 | Immunochemical characterization and quantitative distribution of pancreatic stone protein in sera and pancreatic secretions in pancreatic disorders.
A fluorometric immunoassay has been established to quantitate pancreatic stone protein providing a sensitivity for concentrations from 0.015 to 0.5 micrograms/mL.
When c... | C04 |
8,767 | 8,956 | Hemicorporectomy: a collective review.
Hemicorporectomy or translumbar amputation has been described as the most revolutionary of all operative procedures.
Frederick E.
Kredel, who first voiced the concept of the operation in 1950, referred to it as halfectomy.
Demonstration of his cadaver studies established the f... | C04 |
8,768 | 8,486 | The effect of somatostatin on 5-hydroxytryptamine release from a carcinoid tumor.
One of the major manifestations of the carcinoid syndrome is secretory diarrhea thought to be due to overproduction of 5-hydroxytryptamine (5-HT).
Synthetic somatostatin analogues have proved to be clinically effective in controlling th... | C04 |
8,769 | 2,148 | The diagnosis and definition of hepatic malignancies by use of arterial enhanced computerized tomographic scanning.
Axial computerized tomography is a useful tool in the evaluation of either primary or metastatic hepatic neoplasms.
An adjunct to this technique is visceral arterial enhanced computerized tomography (AE... | C04 |
8,770 | 5,072 | Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer.
Intravesical administration of bacillus Calmette-Guerin has been shown to be highly effective treatment of superficial bladder cancer.
Complications from bacillus Calmette-Guerin therapy are usually minor but serious and e... | C04 |
8,771 | 637 | High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma.
The natural history of gastric epithelial dysplasia and its relation to gastric cancer are ill defined.
A consecutive series of 40 patients with an initial diagnosis of gastric epithelial dysplasia based on examination of endoscopic biopsies ... | C04 |
8,772 | 7,189 | Elevated insulin receptor content in human breast cancer.
The growth of breast cancer cells is under the regulation of hormones, growth factors, and their receptors.
In the present study, we have employed a new, sensitive, and specific radioimmunoassay for the direct measurement of insulin receptors in surgical speci... | C04 |
8,773 | 791 | Left ventricular fibroma: echocardiographic diagnosis and successful surgical excision in three cases.
The management of three patients with left ventricular fibromas is outlined.
All were asymptomatic children.
Routine chest radiography suggested cardiac masses.
M-mode and two-dimensional echocardiography were val... | C04 |
8,774 | 2,223 | Significance and treatment of positive margins or seminal vesicle invasion after radical prostatectomy.
The periprostatic soft-tissue involvement described in the older urologic literature differs from that now recognized; a much "earlier" pathologic stage C is being identified.
Apparent microscopic extension of the ... | C04 |
8,775 | 8,521 | Femoral mononeuropathy after radical prostatectomy.
Femoral mononeuropathy is a recognized complication following abdominal and vaginal hysterectomy.
Retractor injury and lithotomy position were postulated mechanisms.
We report a femoral nerve lesion following a radical perineal prostatectomy. | C04 |
8,776 | 2,557 | Collagen metabolism in gynecologic patients: changes in the concentration of the aminoterminal propeptide of type III procollagen in serum.
We have previously found the serum concentration of the aminoterminal propeptide of type III procollagen, an indicator of collagen metabolism, to be increased in advanced ovarian ... | C04 |
8,777 | 7,584 | Strategy for breakpoint cluster region analysis in chronic myelocytic leukemia in a routine clinical laboratory.
Despite the increasing reliance on breakpoint cluster region (bcr) determinations in diagnosis of chronic myelocytic leukemia (CML), few reports have dealt with the practical aspects of specimen analysis.
... | C04 |
8,778 | 3,331 | Increased survival of patients with massive lymphadenopathy and prostate cancer: evidence of heterogeneous tumour behaviour.
The survival of patients with prostate cancer and radiologically detectable lymph node enlargement has been studied prospectively over an 8-year period.
Computed tomography in 108 patients pres... | C04 |
8,779 | 3,028 | The impact of microinvasion on axillary node metastases and survival in patients with intraductal breast cancer.
A rational approach to the local treatment of intraductal breast cancer continues to generate considerable debate.
However, the finding of an invasive component in intraductal breast cancer is widely regar... | C04 |
8,780 | 6,051 | Mediastinal tracheostomy using a pectoralis major myocutaneous flap after resection of carcinoma of the esophagus involving the proximal part of the trachea.
An operative procedure of mediastinal tracheostomy using a pectoralis major myocutaneous flap is presented.
In this procedure, the terminal portion of the trach... | C04 |
8,781 | 3,433 | Changes in gastric mucosa that antedate gastric carcinoma.
Endoscopic biopsy specimens of the gastric mucosa from 13 patients who were found at follow-up examination to have gastric carcinoma were compared for abnormal histologic features, type of intestinal metaplasia, and presence of immunoreactive carcinoembryonic ... | C04 |
8,782 | 4,801 | Epirubicin cardiotoxicity: a study of 135 patients with advanced breast cancer.
The cardiotoxicity of epirubicin (EPI) was evaluated clinically, radiologically, with ECG, and with multiple ECG-gated radionuclide determination of the left ventricular ejection fraction (LVEF) during rest in 135 patients with advanced br... | C04 |
8,783 | 3,400 | Clear cell adenocarcinoma of the lower genital tract. Correlation of mother's recall of diethylstilbestrol history with obstetrical records.
The written obstetric records of maternal exposure to diethylstilbestrol (DES) were used as a criterion standard and compared with the DES exposure history recalled by mothers of... | C04 |
8,784 | 9,182 | Primary leiomyoma of the liver.
A 30-yr-old woman with right upper quadrant abdominal pain was found to have a hepatic leiomyoma.
This is the youngest patient in whom this rare tumor has been found.
The diagnostic approach toward gastrointestinal leiomyomata is emphasized, including the role of immunohistochemistry. | C04 |
8,785 | 7,776 | Transrectal ultrasonography of rectal carcinoma.
Preoperative transrectal ultrasonographic staging of 38 patients with known adenocarcinoma of the rectum was performed.
Six of these patients had preoperative radiation therapy.
Of the 32 without radiation therapy, transrectal ultrasonography (TRUS) correctly staged d... | C04 |
8,786 | 9,709 | Cathepsins D and E in normal, metaplastic, dysplastic, and carcinomatous gastric tissue: an immunohistochemical study.
Immunohistochemical distributions of cathepsins D and E were determined in normal mucosa, metaplastic, dysplastic, and cancerous lesions of the human stomach.
Cathepsins D and E were localised in the... | C04 |
8,787 | 8,799 | Immunohistochemical differentiation of basal cell epithelioma from cutaneous appendages using monoclonal anti-glycoprotein antibody TNKH1. Its application in Mohs' micrographic surgery.
TNKH1, which was primarily developed to detect differentiated melanocytic tumor cells, was found to recognize basal keratinocytes of ... | C04 |
8,788 | 211 | Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5-fluorouracil, and bleomycin.
The authors treated 14 patients with advanced squamous cell carcinoma (SCC) of the skin or lip with one to four cycles of combination chemotherapy consisting of cisplatin by bolus injection, and 5-fluorouracil (5-F... | C04 |
8,789 | 8,476 | Effects of tamoxifen and somatostatin analogue on growth of human medullary, follicular, and papillary thyroid carcinoma cell lines: tissue culture and nude mouse xenograft studies.
The knowledge that (1) the normal thyroid contains somatostatin, (2) polypeptide growth factors influence thyroid cell function, and (3) ... | C04 |
8,790 | 6,924 | Medical comorbidity of major depressive disorder in a primary medical practice.
Despite much speculation about the relationship between depression and medical comorbidity in primary care settings, few investigators have examined this issue empirically.
Using a two-stage screening procedure, we assessed 618 patients a... | C04 |
8,791 | 5,565 | Fluorescein angiography in ciliary body melanomas.
We retrospectively studied the value of iris fluorescein angiography in predicitng benignity or malignancy in 10 cases of ciliary body melanoma with iris extension.
No correlation between fluorescein-angiographic appearance and histopathologic features was observed.
... | C04 |
8,792 | 2,903 | Magnetic resonance imaging in neurological disorders.
To investigate the role of magnetic resonance imaging (MRI) in neurological disorders, 115 children were studied in two groups.
Group A (78 patients) was studied by paired computed tomography and MRI cranial scans.
Group B (37 patients) was studied by paired comp... | C04 |
8,793 | 2,415 | Brake mechanics, asbestos, and disease risk.
Health risks posed by inhalable asbestos fibers are known to exist in a variety of industrial and nonindustrial settings.
Although early studies described an increased risk of asbestosis, lung cancer, and mesothelioma in asbestos-industry workers, subsequent research revea... | C04 |
8,794 | 9,994 | Progression of stage T1 bladder tumors after intravesical bacillus Calmette-Guerin [published erratum appears in J Urol 1991 Apr;145(4):840]
Of 221 patients with superficial bladder tumors (stages Ta, Tis and T1) treated by transurethral resection and an initial 6-week course of intravesical bacillus Calmette-Guerin (... | C04 |
8,795 | 7,208 | A phosphatase activity present in peripheral blood myeloid cells of chronic myelogenous leukemia patients but not normal individuals alters nuclear protein binding to transcriptional enhancers of interferon-inducible genes.
Cytoplasmic protein from peripheral blood myeloid cells of chronic myelogenous leukemia (CML) p... | C04 |
8,796 | 8,493 | Actin architecture of cultured human thyroid cancer cells: predictor of differentiation?
The actin cytoskeleton is important for cell structure and motility.
A disordered actin architecture has been correlated with a high metastatic potential in melanoma, fibrosarcoma, and colon cancer models.
Thyrotropin is known t... | C04 |
8,797 | 4,518 | Oncogenes and suppressor genes: their involvement in colon cancer [editorial]
Abnormalities in oncogenes, which are broadly classified into viral and cellular oncogenes, and suppressor genes appear critical for the development of colon cancer.
Cellular oncogenes contribute to malignant transformation when they become... | C04 |
8,798 | 4,307 | Tissue preparation for simultaneous flow cytometric quantitation of tumour associated antigens and DNA in solid tumours.
A multiparameter flow cytometric assay for the simultaneous study of tumour associated antigens (TAA) and DNA in fresh solid tumours was devised.
Cell suspensions were prepared by disaggregating un... | C04 |
8,799 | 4,331 | Buschke-Loewenstein tumor: verrucous carcinoma of the penis.
The Buschke-Loewenstein tumor is an anogenital tumor of characteristic clinical and histologic pattern best considered as a low-grade, well-differentiated squamous cell carcinoma.
This remarkable neoplasm and its features are reviewed in detail, stressing s... | C04 |
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