PMC_ID stringlengths 8 11 | Image_num stringclasses 399 values | Online_file_path stringlengths 20 50 ⌀ | Image_info_Cleaned stringlengths 2 20.6k | Caption_Clean stringlengths 1 10.6k ⌀ | label stringclasses 2 values |
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PMC9289505 | Figure_4 | oa_package/51/ed/PMC9289505.tar.gz | ['4a), coronal section of T2WI sequence showed bone destruction reaching subchondral bone plate (b).', ''] | Fig. 4 a. T1+Contrast is shows the enhancing solid mass after contrast administration; 4b. Coronal T2WI shows that the bone destruction is reaching the subchondral bone plate. | yes |
PMC7616318 | Figure_3 | oa_package/a8/ac/PMC7616318.tar.gz | ['The regression of basal skull dLVs was especially prominent around the pterygopalatine artery (PPA) and its branches, above the cribriform plate and around the optic nerves (Extended Data b f).', 'In contrast, dLVs around the foramen magnum and the spinal canal were affected only minimally (Extended Data g,h).', 'Body, dcLN or spleen weights or dcLN LYVE1+ area coverage did not differ between genotypes or treatment groups at either age (Extended Data i o).', 'Notably, unlike in the photoablation study31, we detected A staining also in the dura mater of AD mice without dLV regression (a f and Extended Data ', 'The staining was mainly associated with podocalyxin+/vWF+/BMX BVs connecting brain to dura mater, namely bridging veins, that are known to drain blood from brain into the large dural venous sinuses (a f and Extended Data ', 'The most prominent A staining was associated with the bridging veins that join transverse sinuses (TSs) and with the rostral end of the superior sagittal sinus (SSS) (a f).', 'However, A staining was associated with the bridging veins all along the SSS (a f and Extended Data ', 'A staining did not consistently colocalize with dLVs (d f and Extended Data ', '4a f) and staining was present in similar locations also in the dura mater of mice lacking the dorsal dLVs (a c).', 'The ICPs were not significantly different between AAV-sR3-versus AAV-Ctrl-treated WT mice after 12 months of treatment, indicating that the CSF outflow system can compensate for the loss of the dLVs (Extended Data p).', 'Extended Data AAV-sR3 induced dLV regression in APdE9 mice does not affect LN, spleen, or body weight, or ICP.', 'xlsx" id="d67e2285" position="anchor"/>Source Data Extended Data <media xlink:href="EMS196559-supplement-Source_Data_Extended_Data_Fig__3.', 'A deposits in dura mater are associated with bridging veins, but not with dLVs.'] | Extended Data Fig. 3 AAV-sR3 induced dLV regression in APdE9 mice does not affect LN, spleen, or body weight, or ICP. , Comparison of littermate AAV-Ctrl and AAV-sR3 treated WT and APdE9 mice at 6 (female) and 16 (male) months of age. , Simplified schematic illustration of dLVs (green) attached to the basal cranium and spinal canal after removal of the brain and spinal cord. , Comparison of dLVs (white) in PPA region at ( ) 6 months (n = 9,11,7,9), and ( ) 16 months (n = 3,3,3,3) of age. , Comparison of dLVs (white) in ( ) CP, ( ) foramen magnum (FM), and ( ) SC region. , Comparison of ( ) dcLN weight at 6 (n = 14,15,5,7) and 16 (n = 17,20,10,11) months of age ( ) spleen weight at 6 (n = 5,5,7,3) and 16 (n = 14,20,10,11) months of age, and ( ) body weight at 6 (n = 19,19,13,11) and 16 (n = 14,20,10,11) months of age. LN weight represents an average of both sides (left and right) and maximum one dcLN per side per mouse was used in quantification. ( ) Representative images of LYVE1 (white) staining in dcLNs. , Comparison of intracranial pressure (ICP) in 14-month-old WT-Ctrl vs WT-sR3 (female mice; n = 7,7) groups 12 months after AAV injection. Yellow arrowheads point to different dLV branches. Data shown are representative of at least two independent experiments using littermate mice. Datapoints in graphs represent individual mice. values were calculated with ( ) unpaired two-tailed -test, ( ) two-way ANOVA, ( ) three-way repeated measures ANOVA, and ( ) three-way repeated measures mixed-effects model with Tukeys post hoc test for multiple comparison in ( ). Data are presented as mean values s.e.m. Scale bars: 200 m ( ), and 400 m ( ). | yes |
PMC5074821 | Figure_2 | oa_package/76/b5/PMC5074821.tar.gz | ['Location was confirmed by aspiration of blood ().', 'Opacification of the arterial pseudoaneurysm with a 19-gauge Cook needle, with retrograde filling of the feeding vessel.'] | Figure 2 Opacification of the arterial pseudoaneurysm with a 19-gauge Cook needle, with retrograde filling of the feeding vessel. | yes |
PMC11241383 | Figure_4 | oa_package/72/92/PMC11241383.tar.gz | ['Additionally, surgical drainage of multiple loculated intraorbital abscesses and excision of necrotic orbital fat were performed through a sub-brow incision, along with the extraction of teeth 13, 15, and 16 (, and ).', 'Extraction of teeth 13, 15, and 16: (a) intraoperative photo; (b) teeth 13, 15, and 16 extracted.'] | Figure 4 Extraction of teeth 13, 15, and 16: ( ) intraoperative photo; ( ) teeth 13, 15, and 16 extracted. | yes |
PMC3812850 | Figure_4 | oa_package/1a/f9/PMC3812850.tar.gz | ['Disruption of the subsheath occurs at three main sites (figure 4).'] | Figure4 (Subsheath disruption) The types of subsheath rupture comprise (A) normal, (B) periosteal stripping resulting in a false sheath, (C) fibro-osseous sheath rupture at the ulnar side, (D) fibro-osseous sheath rupture at the radial side and (E) a contracted but intact fibro-osseous sheath. | yes |
PMC5939705 | Figure_1 | oa_package/6a/1c/PMC5939705.tar.gz | ['S1) and dGNT () in 13 cases.', '0001; A) and cortical atrophy found in 92% cases (12/13) with thinning in the region of tumor infiltration and retraction with focal prominence of the overlying sulcus forming a CSF filled space ('] | FIGURE 1. Diffuse GNT. Case 10 and Case 19 . Coronal T2 weighted images showing cortical based lesion of high signal intensity with subcortical white matter involvement involving the right fusiform gyrus. Note the cortical part of the lesion that is creating a bridge into the adjacent sulcus (between arrowheads) shown in higher magnification. There is signal change in the white matter (arrow). Macroscopic image of fixed resection specimen with the slice corresponding to the lesion seen on MRI; there is focal peri-operative acute hemorrhage into the expanded gyrus. H&E-stained section indicates the infiltrated gyrus (between arrows) and underlying rarefaction in the white matter correlating with loss of myelin and axons (arrow). CD34 of the same gyrus at high magnifications shows the diffuse cellular infiltration of the cortex bridging over to the next gyrus. Case 19: dGNT (which also had areas of mixed complex DNT, not shown here) with lesion in MRI in the amygdala (arrow). In the temporal lobe resection, diffuse infiltration was confirmed in the inferior-mesial part of the cortex (arrow). Depletion of neurons seen in this region of diffuse tumors infiltration on NeuN stain (arrow). Diffuse tumor infiltration in the grey matter from the tissue of the lesion in the amygdala. This same region shows CD34 positivity of tumor cells. Bars: =500m; = 300m. | yes |
PMC4231287 | Figure_7 | oa_package/9f/e9/PMC4231287.tar.gz | [' 7a, b), but not rCDR2L (1.', ' 7b).', ' 7c f; Table 1) and blocked the increased PKC protein expression caused by rCDR2 and rCDR2/2L internalization (', ' 7g, h; #\np 0.', '', '003; Table 1: CDR antibody effects in percentage\nThe results show that the CDR antibody-mediated pathology can be attenuated in the presence of VGCC, AMPA receptor, and PKC signaling inhibition.'] | Fig.7 Protein kinase C gamma expression is up-regulated by CDR2 and CDR2/2L-Ab internalization. Representative Western blot: PKC expression after CDR internalization. PKC expression was significantly increased after CDR2 and CDR2/2L internalization (125ng/mL; 6 days; =14). Multiphoton micrographs demonstrate that the CDR2/2L -induced loss of CB ( ) and L7/Pcp-2 ( ) was minimized by PKC antagonist K252a (50nM) co-treatment; 40m. Stereological counting of CB and L7/Pcp-2 PCs in the obtained micrographs supported the positive effect of K252a on CDR antibody-induced pathology by showing a loss of <10% compared to control ( CDR2/2L [4L/mL] CB: =4; L7/Pcp-2: =4; CDR2 and CDR2L [125ng/mL] CB: =6; L7/Pcp-2: =6). Representative Western blot: PKC expression after CDR/K252a co-treatment. K252a co-treatment reduces the CDR-induced PKC expression rise in the CDR2 and CDR2/2L group (125ng/mL; =5) after K252a co-treatment. Investigated samples: 6days of CDR internalization; data in meanSEM; non-parametric two-tailed paired MannWhitneys test. * <0.05; ** <0.01; *** <0.001; <0.003; Table : CDR antibody effects in percentage | yes |
PMC3088854 | Figure_10 | oa_package/3a/09/PMC3088854.tar.gz | [] | Fig. 10 Median nerve neurofibroma. Real time sonoelastography image of median nerve neurofibroma (arrows) in patient of neurofibromatosis. Lesion shows predominant green color representing uniform firmness. Axial MRI reveals median nerve neurofibroma (arrows). B = brachialis, BA = brachial artery, L = lateral epicondyle, M = medial epicondyle, O = olecranon, UN = ulnar nerve | yes |
PMC6760880 | Figure_1 | oa_package/0f/cf/PMC6760880.tar.gz | ['CT scan abdomen and pelvisRed arrow: jejuno-jejunal intussusception; Blue arrow: dilated bowel proximal to the obstruction; Black arrow: normal caliber bowel distal to the obstructionThe patient was taken to the operating room, and laparoscopic resection of the segment in question was performed.'] | Figure 1 CT scan abdomen and pelvis Red arrow: jejuno-jejunal intussusception;Blue arrow: dilated bowel proximal to the obstruction;Black arrow: normal caliber bowel distal to the obstruction | yes |
PMC4173111 | Figure_2 | oa_package/d9/2c/PMC4173111.tar.gz | [' 2.', '', ' 2Changes observed at 4 and 7 days post-inoculation (dpi) in the lungs of pigs infected intratracheally with swine influenza virus (H1N1) and in control pigs\nPresence of SIV in swabs and tissuesRRT-PCR assay revealed positive results in nasal swabs taken between 1 and 7 dpi from all infected pigs (Table 1).'] | Fig.2 Changes observed at 4 and 7 days post-inoculation (dpi) in the lungs of pigs infected intratracheally with swine influenza virus (H1N1) and in control pigs | yes |
PMC4636375 | Figure_3 | oa_package/0e/e5/PMC4636375.tar.gz | ['In vitro treatment with 500 nM 4-hydroxy tamoxifen (4-OHTMX) induced MCV sT expression in Ubc\nCreERT2; ROSA\nsT MEFs (n = 8 embryos) but not ROSA\nsT MEFs (n = 2 embryos) (A).', 'ref012" ref-type="bibr">12], was also increased by MCV sT expression ( and <xref rid="pone.', 'Wst-1 cell proliferation assay demonstrated that accelerated growth occurred in Ubc\nCreERT2; ROSA\nsT but not ROSA\nsT MEFs ( and <xref rid="pone.', 'g003MCV sT induces hyperproliferaton in MEF cells.'] | 10.1371/journal.pone.0142329.g003 | yes |
PMC7546949 | Figure_2 | oa_package/ff/88/PMC7546949.tar.gz | [] | Figure1 Kidney biopsy findings from representative cases. (A) Case 7, acute tubular necrosis; (B) case 7, collapsing glomerulonephritis (GN); (C) case 6, collapsing GN; (D) case 9, collapsing GN and thrombotic microangiopathy (TMA); (E) case 8, TMA (A-E: Jones methenamine silver; original magnification,400); (F) case 8, TMA (electron microscopy; original magnification,20,900). | yes |
PMC10297602 | Figure_22 | oa_package/54/6e/PMC10297602.tar.gz | [] | Figure 22 Sagittal T2 ( ), T1 ( ) and axial T2 ( ) images of a benign notochordal remnant of L3 (white arrows). The central location within the vertebral body, and the low T1 and high T2 signal are typical features. | yes |
PMC5070838 | Figure_3 | oa_package/3c/12/PMC5070838.tar.gz | ['1 cm conventional papillary carcinoma with metastasis to the bone tissue and soft tissue extension (, , ).', ''] | Fig. 3 Pathological report. Hyoid bone resection. | yes |
PMC6299997 | Figure_4 | oa_package/dd/57/PMC6299997.tar.gz | ['4a).', '4a, b).', '4c, d).', 'd Quantification of the immunofluorescence result (% of activated fibroblasts showing clear expression of -SMA fibers and PTK2)The increase in the levels of DNA damage induced by vitamin D in the presence of bleomycin is not mediated by ROSIn the presence of Fe2+ and O2, bleomycin causes single-strand DNA breaks and DSBs.'] | Fig. 4 Effect of vitamin D on the fibrogenic activation of myofibroblasts. RT-qPCR result: expression of a representative profibrogenic cluster of genes. Cells were pretreated with 5nmol/L vitamin D for 2h, subjected to a bleomycin shock (12g/mL for 6h) and then treated with 5nmol/L vitamin D or its vehicle. Analysis was performed 72h post-shock. Values are folds of induction over control cultures (treated with bleomycin vehicle: PBS); veh.: vitamin D vehicle. The results presented in the figures are means SEM. Significance of the analysis is indicated as ***, <0.001. Detection of VIM (vimentin) and ACTA2 (-SMA) in myofibroblasts cell extracts. Cells were pretreated with 5nmol/L vitamin D for 2h, subjected to a bleomycin shock (12g/mL for 6h) and then treated with 5nmol/L vitamin D or its vehicle. Cell extracts were obtained at 72h post-shock. PBS is the bleomycin vehicle; veh.: vitamin D vehicle. TUBA1A (tubulin ) was used as loading control. KDa: kilodaltons. Bottom panel: densitometry analysis of bands; a.u.: arbitrary units. Representative micrographs of indirect immunofluorescence detection of ACTA2 (-SMA fibers) and PTK2 (focal adhesion kinase), two markers of the profibrogenic activation. Cells were pretreated with 5nmol/L vitamin D for 2h, subjected to a bleomycin shock (12g/mL for 6h) and then treated with 5nmol/L vitamin D or its vehicle. Cells were processed for immunofluorescence 72h post-shock. Quantification of the immunofluorescence result (% of activated fibroblasts showing clear expression of -SMA fibers and PTK2) | yes |
PMC9420252 | Figure_6 | oa_package/8f/22/PMC9420252.tar.gz | [' 6a), suggesting a protective effect of MLKL deficiency in high glucose-stimulated cardiomyocytes.', ' 6b, c, Additional file 1: Table S3).', ' 6d) and attenuated CK-MB and troponin I levels in sera (', ' 6e, f), reduced myocardial collagen deposition in STZ-injected mice (', ' 6g).', ' 6g, Additional file 1: Table S4).', 'Effects of MLKKL knockout in streptozocin (STZ)-induced diabetic hearts.', '05 versus STZ + WT (ANOVA)Knockdown of MLKL attenuates cardiomyocyte necroptosis in akita type-1 diabetic miceTo provide further evidence to support the role of MLKL in cardiomyocyte necroptosis in diabetes, we knocked down MLKL in akita type-1 diabetic mouse hearts by systemic delivery of shRNA against MLKL (pshMLKL).'] | Fig. 6 Effects of MLKKL knockout in streptozocin (STZ)-induced diabetic hearts. Adult cardiomyocytes isolated from MLKL knockout (MLKL-KO) and wild-type mice (WT) were incubated with high glucose or Mannitol (25mmol/L) for 24h. LDH was measured in culture medium. MLKL-KO and WT mice were rendered diabetic by STZ injection. and Echocardiographic analysis for myocardial function. Necrotic cell death in the heart was determined by Evans blue staining assay. Upper panel: representative micro-photograph for necrotic cells in the heart; Bottom panel: quantification of necrotic cell death. and Biomarkers of myocardial injury: serum CK-MB ( ) and cardiac troponin I ( ). Myocardial fibrosis was assessed by collagen deposition in the heart. Upper panel: representative micro-photograph for collagen deposition in the heart (red); Bottom panel: quantification of collagen deposition. Data are meanSD, n=56. * <0.05 versus Sham+WT and <0.05 versus STZ+WT (ANOVA) | yes |
PMC9840207 | Figure_4 | oa_package/c9/85/PMC9840207.tar.gz | ['DB-82-CB77 exhibits dose-dependent and sustained inhibition of LPS-induced systemic and ocular complement activity in young wild-type mice (A and B).', 'DB-82-CB77 fully inhibits ocular complement activation as soon as 4 h and up to 12 16 h post-administration as measured by quantification of the complement products C3d and iC3b levels in young and older C57BL/6 mice after a single dose or repeated daily dosing of 60 mg/kg for 8 weeks (B, Supplementary Material, ', 'Oral complement FB inhibitor DB-82-CB77 potently inhibited complement activation and reduced sub-RPE deposit accumulation in female Efemp1ki/ki mice.', 'Plasma levels of basal complement breakdown products, C3d and Ba, were significantly reduced in DB-82-CB77-treated mice (C), confirming systemic inhibition of the spontaneous/tick-over complement activity.', 'Sub-RPE deposits were measured as the total area of deposits across the entire thin section from the temporal-ventral and nasal-dorsal regions at the level of the optic nerve for each eye as outlined in representative TEM images (D).', '029), while no differences were identified in males (vehicle n = 14, treated n = 15) (E).', 'Sub-RPE deposits were 64% smaller in vehicle-treated Efemp1ki/ki males compared with females (E).', 'The reduced basal complement activity in males versus females in plasma (C) is consistent with a lower AP activity leading to slower sub-RPE deposit accumulation and supports a critical role of AP complement activation in the formation of sub-RPE deposits.'] | Figure 4 Oral complement FB inhibitor DB-82-CB77 potently inhibited complement activation and reduced sub-RPE deposit accumulation in female mice. ( ) Dose response relationship of oral small molecule FB inhibitor/FB compound, DB-82-CB77, in the mouse LPS-induced complement activation model, and 7-week-old female C57BL/6 mice were challenged with LPS or PBS control i.p. Three and half hours later, mice were orally administered with either vehicle or DB-82-CB77 at doses ranging from 1 to 30mg/kg, plasma and eye tissues were collected 4h after compound dosing and analyzed for complement activities by western blot. Inhibition of LPS-induced C3d+iC3b generation by DB-82-CB77 is expressed as % inhibition of C3d+iC3b SEM which is estimated as 100[1(compound groupaverage PBS group)/(average LPS groupaverage PBS group)]. DB-82-CB77 inhibited LPS-induced ocular and systemic C3d+iC3b generation in a dose-dependent manner. <0.01, <0.001, <0.0001. ( ) A time course of a single 60mg/kg oral dose DB-82-CB77 in mouse LPS-induced complement activation model. Complement C3d+iC3b levels were expressed relative to baseline PBS-treated group. LPS treatment induced over 2-fold complement levels above the PBS level. Near complete AP inhibition lasted out to 16h after single dose of DB-82-CB77 in ocular tissues and partial inhibition in plasma at 16h. <0.01, <0.001. ( ) DB-82-CB77 inhibits plasma basal complement levels in mice. Male and female 10-month-old mice were dosed orally with either vehicle (veh) or DB-82-CB77 (FB compound) daily for 8weeks. Plasma samples were collected 4h post-dosing with DB-82-CB77 and analyzed for complement breakdown products by western blot. Plasma C3d and Ba levels were expressed relative to male vehicle group values. Female mice have higher basal plasma C3d and Ba levels than male mice. Plasma C3d and factor Ba were reduced ( <0.05) in both male and female mice. <0.05, <0.01. ( ) TEM mages are representative of both vehicle (left) and DB-82-CB77 (right)-treated mice. Images are from comparable quadrants of retinal sections. Deposits are outlined in yellow. Arrows indicate Bruchs membrane. The white dots in Bruchs membrane are unstained collagen fibrils. Magnification=18500.( ) Average sub-RPE deposit area in female and male mice treated with either vehicle or FB inhibitor DB-82-CB77. Electron microscopy was performed on 1416 eyes per group. Images of basal laminar deposits were collected at a direct magnification of 18500. Sub-RPE deposit area in each image was determined using ImageJ. All deposit area from the entire temporal/ventral and dorsal/nasal retinal section were summed as the total deposit area per eye. Eyes from female mice dosed with DB-82-CB77 for 8weeks showed a 65% reduction in sub-RPE basal deposit area ( =0.029) comparing with female vehicle controls, using one-way AVOVA Dunnetts multiple comparison test. Female mice have 64% more sub-RPE deposits than male mice ( =0.038). | yes |
PMC3534252 | Figure_1 | oa_package/5e/6e/PMC3534252.tar.gz | ['After resuscitation she underwent a CT scan revealing a large right RH ().', '0-064228330012882069CT retroperitoneal hematoma (Case 1) a large extraperitoneal hematoma measuring 18.'] | Figure 1 CT retroperitoneal hematoma (Case1)a large extraperitoneal hematoma measuring 18.3 11.2cm arising from the posterior surface of lower part of left rectus abdominis muscle and extending into the pelvis causing right sided displacement of pelvic organs. | yes |
PMC7993245 | Figure_11 | oa_package/e0/5d/PMC7993245.tar.gz | [] | Figure 4a: Examples of image-level annotations on axial CT images indicated with orange regions of interest. Infectious opacity segmented in the left upper lobe. Infectious tree-in-bud and/or micronodules segmented in the right lower lobe. Infectious cavity segmented in the right upper lobe. Noninfectious nodule or mass segmented in the posterior left pleura. Atelectasis segmented in the left lower lobe. Other noninfectious opacity segmented in the right lower lobe. | yes |
PMC8487757 | Figure_6 | oa_package/d4/19/PMC8487757.tar.gz | ['The final diagnosis was usual interstitial pneumoniaStatistical analysisThe Statistical Package for Social Sciences (SPSS for Windows 24.'] | Fig. 6 Case example defined in the indeterminate for the BSTI guidance statement, and in the typical category for the RSNA expert consensus statement. An axial chest CT image of a 68-year-old male without COVID-19 shows peripheral multifocal GGOs (arrows) in the background of moderate emphysema. The final diagnosis was usual interstitial pneumonia | yes |
PMC11605496 | Figure_2 | oa_package/4a/a9/PMC11605496.tar.gz | [] | FIGURE 2 Illustration of follicular vessel growth in DOCT scans. In the (A) clinical photograph, an actinic keratosis (AK) grade I is marked by a blue arrow. Below the clinical photograph is the corresponding (B) dermatoscopic image, which reveals a strawberry pattern characterized by background erythema/red pseudonetwork intermingled with follicular plugs with whitish halos and linear/wavy vessels encircling the follicles. DOCT enface scans illustrate an arrangement of perifollicular dotted vessels at (C) 150m depth and perifollicular branched vessels at (D) 300m depth. | yes |
PMC3388011 | Figure_10 | oa_package/21/62/PMC3388011.tar.gz | [] | Figure 10 Control untreated 14-month APP/PS1 mice, dasatinib infused mice or vehicle infused controls (n=7) were used for T maze testing on Day 29 following 28days of drug or vehicle infusion. The mean number of spontaneous alternations +/ SEM per treatment group were graphed. (* <0.05 vs. control, *** <0.001 vs. vehicle). | yes |
PMC11506126 | Figure_2 | oa_package/19/94/PMC11506126.tar.gz | ['Excision of the mucosal mass using laserThe excised tissueImmediate postoperative photograph after the removal of the mucosal growthA pressure pack was applied to the surgical site to aid in healing after the lesion was completely removed.'] | Figure 2 Excision of the mucosal mass using laser | yes |
PMC9327202 | Figure_7 | oa_package/3b/55/PMC9327202.tar.gz | [' 7, Additional File 10: ', ' 7a,b).', ' 7a,b).', ' 7c), recapitulating expected functional properties of the ABI family members [37].', ' 7d).', ' 7e).', ' 7e).', ' 7f), KEGG pathways (Additional File 10: ', ' 7d, Additional File 10: ', 'Unbiased transcriptomic analysis of TG-Abi3-Gngt2 / mice reveal distinctive disease-associated gene expression signatures and co-expression modules.', 'All p-values adjusted for multiple comparisons (padj)Exacerbated ptau accumulation in Abi3Gngt2-/- mice expressing human mutant tauBecause of the inherent dysfunctional immune milieu and early astrocytosis in the Abi3-Gngt2 / mice, we decided to test how this would affect the development and progression of tauopathy.'] | Fig. 7 Unbiased transcriptomic analysis of TG- mice reveal distinctive disease-associated gene expression signatures and co-expression modules. Volcano plot ( ), list of top 5 upregulated and top 5 downregulated genes (based on fold change; orange, upregulated genes, blue, downregulated genes) ( ) and GO pathways based on enriched genes for upregulated genes ( ) in 3-month-old TG mice with WT (+/+), or KO (/) of locus. Orange dots, upregulated genes; blue dots, downregulated genes. FC, fold change; DEG, differentially expressed genes; padj, -values adjusted for multiple comparison. Cell type population analyses indicating changes in microglia, astrocytes, neurons, and oligodendrocyte populations in 3-month-old TG mice with WT (+/+), heterozygous (+/), or KO (/) of locus. One-way ANOVA; ** <0.01, * <0.05. Gene expression signatures for specific microglia or astrocyte subtypes in 3-month-old TG mice with WT (+/+), heterozygous (+/), or KO (/.) of locus. One-way ANOVA; * <0.05. WGCNA gene co-expression modules correlating with experimental traits (biochemical A values, plaque burden, Iba-1 burden, GFAP burden, - genotype). Correlation of modules to different experimental traits is colored in a heatmap (red, positive correlation; blue, negative correlation). Modules with -values<0.05 and correlation value<-0.5 0r >0.5are indicated in colored tile (see scale on right). Cell-type-specific gene lists were used to identify genes with significant overlap (odds ratio) within the modules. The heatmap is colored by the value of the odds ratio; higher the odds ratio of association, warmer the color. Grey squares indicate non-significant ( >0.05, odds ratio<2) overlaps in the gene lists. =4 mice (2 males, 2 females) per genotype except 1 outlier removed in , . All -values adjusted for multiple comparisons (padj) | yes |
PMC2965244 | Figure_2 | oa_package/ef/00/PMC2965244.tar.gz | ['Rescue hearts have decreased de novo transcription of mtDNA but near-normal steady-state levels of transcriptsWe assessed de novo transcription of mtDNA in rescue heart mitochondria with in organello transcription assays and found a decrease of at least 45% in comparison with control heart mitochondria (A).', 'There was a profound decrease of 7S RNA transcripts in rescue hearts in comparison with control hearts (B and C).', '.', 'No significant changes were observed in hearts of 12-week-old rescue animals (D) and a moderate decrease of steady-state levels of the COX1 mRNA and the 16S rRNA was present in 52-week-old rescue animals (E).'] | Figure 2. Measurement of transcription. ( ) transcription of 16-week-old rescue and control hearts, followed by normalization by Northern blotting for the mitochondrial transcripts of ND6. ( ) Schematic diagram of the murine mtDNA control region containing tRNA (T), tRNA (P), TAS 1 and 2, 7S RNA transcript, 7S DNA fragment, conserved sequence blocks 13 (CSB), LSP, HSP and tRNA (F). ( ) S1 protection assay of LSP proximal transcription (7S RNA) and control transcript (ND6) of control (C) and rescue (R) mitochondrial RNA extracts. ( and ) Relative transcript levels normalized to the nuclear 18S rRNA transcript. Levels of the mitochondrial transcripts of COX1 (light grey bars) and ND6 (dark grey bars) and the large mitochondrial ribosomal subunit 16S rRNA (white bars) are shown at 12 (D) and 52 weeks (E). Data are presented as means SEM percentage of controls; * < 0.05; *** < 0.001, respectively. | yes |
PMC9409081 | Figure_1 | oa_package/aa/76/PMC9409081.tar.gz | ['Due to this fact, K+ efflux could promote Ca2+ influx and increase cytosolic Ca2+ concentrations, leading to NLRP3 activation [36,48,49] ().', '1016/0006-8993(87)90368-42885066The mechanisms of priming and activation of the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.'] | Figure 1 The mechanisms of priming and activation of the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. Firstly, protein aggregates (A and tau) are recognized by microglial pattern recognition receptors, such as Toll-like receptors (e.g., TLR2, TLR4), or cluster of differentiation 36 (CD36). Afterwards, they induce activation of specific pathways like MYD88/NF-B, which leads to transcription of pro-IL- and NLRP3. One of the NLRP3 domainsthe adaptor molecule apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)recruits pro-caspase-1, which enables the release of inflammatory cytokines, namely IL-18 and IL-. Further, cell death in the form of pyroptosis occurs after the activation of NLRP3 via the induction of gasdemin D (GSDMD). GSDMD can induce membrane-disrupting cytotoxicity and facilitates the secretion of inflammatory cytokines via the creation of pores in the cell membrane. | yes |
PMC7432645 | Figure_1 | oa_package/ac/c7/PMC7432645.tar.gz | ['Ids KO;TfRmu/huKI mice received 4-weekly IV doses of vehicle, ETV:IDS or idursulfase (IDS), which does not effectively cross the blood brain barrier (A) [31], and GAG levels in brain and CSF were assessed seven days following the last dose using LC-MS/MS.', '(B,C).', 'Comparison of brain and CSF GAG levels in individual Ids KO animals across treatment groups (vehicle, IDS and ETV:IDS) showed a significant positive correlation for ETV:IDS, suggesting that GAG levels in CSF could potentially serve as a surrogate for GAGs levels in the brain (D).', 'xCorrelation between brain and CSF GAGs in Ids KO;TfRmu/huKI mice.'] | Figure 1 Correlation between brain and CSF GAGs in KO;TfR KI mice. GAG levels were evaluated in the brain and CSF of KO;TfR KI mice following treatment with increasing doses of ETV:IDS. TfR KI mice served as non-disease controls; ( ) ETV:IDS is the lysosomal enzyme (E) iduronate 2-sulfatase (IDS) fused to the Transport Vehicle (TV), a TfR-binding Fc domain. KO;TfR KI were treated with 4-weekly intravenous doses of vehicle, ETV:IDS or IDS alone. Brain ( ) and CSF ( ) were harvested 7 days following the last dose and GAGs were measured using LC-MS/MS; ( ) correlation between brain and CSF GAG levels of KO;TfR KI treated with ETV:IDS or IDS. Pearson r was used to determine the correlation coefficient. Graphs display mean SEM and values: one-way ANOVA with Dunnett multiple-comparison test; **** < 0.0001; = 5 per group. | yes |
PMC6219843 | Figure_10 | oa_package/7d/f9/PMC6219843.tar.gz | [] | 10.7554/eLife.40202.012 | yes |
PMC8664396 | Figure_1 | oa_package/ab/f9/PMC8664396.tar.gz | ['Proper intraoperative allograft interbody placement to create the kissing ACDF construct.'] | Figure 1 Proper intraoperative allograft interbody placement to create the kissing ACDF construct. (A) intraoperative image demonstrating a completed cervical discectomy with removal of the posterior longitudinal ligament. A trial spacer is inserted inside the discectomy defect to select an appropriate interbody height. In this case, a 7mm trial was chosen. (B) Two 7mm structural allografts are then circumferentially shaved with the high-speed electric drill in order to allow them to fit in a parallel orientation in the discectomy defect. The sample allograft on the left-hand of the image demonstrates the allograft prior to shaving. (C) The shaved allografts are filled with bone dust (or demineralized bone matrix) collected with the specimen trap and then gently tamped into the discectomy defect (D) Final intraoperative view of the kissing allografts. | yes |
PMC11632536 | Figure_1 | oa_package/33/70/PMC11632536.tar.gz | [] | FIGURE 1 Artificial intelligencebased volumetry report. Excerpt from a volumetry report of a study patient diagnosed with frontotemporal dementia. The measured volumes from in total 18 brain regions (including the hippocampus) are determined from the segmentation and then automatically compared against an age and sexmatched reference cohort of healthy individuals( =3179)to yield percentiles. The entire analysis runs in < 5 minutes. Volumes and percentiles are displayed in tabular format, along with clinically relevant magnetic resonance imaging slices and schematics to highlight pathological values beyond two standard deviations from the mean. | yes |
PMC8536526 | Figure_3 | oa_package/d7/c7/PMC8536526.tar.gz | ['On gross examination, (A) there was a solid mass from the right ovary measuring 18 15 14 cm, the surface was smooth and free of adhesions with a yellowish interior, and no papillary growths or cystic structures were found.', 'The frozen section results showed that the tumor tissue was arranged in a solid and diffuse pattern that matched the AGCT (', 'Slightly coarse chromatin, some with the nucleolus, eosinophilic cytoplasm, nuclear groove formations, and call Exner bodies, were seen (C).', 'The foci consist of a proliferation of granulosa cells that appear solid with well-defined margins and many cystic cavities between them (D).', 'Tumor cells are round, small, relatively uniform, with some deep-stained nuclei (E).'] | Fig. 3 On gross examination, (A) there was a solid mass from the right ovary measuring 181514cm, the surface was smooth and free of adhesions with a yellowish interior, and no papillary growths or cystic structures were found. On microscopic examination, it was found (B) AGCT with 100 magnification showing solid and diffuse tumor tissue; (C) AGCT with 400 magnification shows nuclear groove (white arrow), mitosis (black arrow), and Call Exner body (red arrow); (D) JGCT with 100 magnification shows solid tumor tissue with well-defined margin forming papillary with many follicular-like structures (white arrow); (E) JGCT with 400 magnification showed small round tumor cells with deep-stained nuclei and eosinophilic cytoplasm without a nuclear groove or Call-Exner body. | yes |
PMC7581507 | Figure_5 | oa_package/4a/fc/PMC7581507.tar.gz | ['The anterior leaflet was noted to be slightly thickened but otherwise satisfactory ( 5).', ' 5Intraoperative view before intervention highlighting the ULMV.'] | Figure4 Cardiac computed tomography demonstrating non-delaminated posterior leaflet. Three projections through the left ventricle showing non-delaminated posterior leaflet with rudimentary remnants of subvalvular apparatus. | yes |
PMC10616862 | Figure_1 | oa_package/cf/76/PMC10616862.tar.gz | ['The absorbing cells became necrotic, they shed, and the cell arrangement gradually loosened as the infection progressed over time (A).', 'Changes in the intestinal mechanical barrier of A.', 'splendidus in the midgut tissue, as examined by Western blotting and immunofluorescence ().'] | Figure 1 Changes in the intestinal mechanical barrier of with infection. H&E staining of the section of the intestine. Immunofluorescence of ZO-1 and occludin in the intestine. RT-PCR analysis of occludin and ZO-1 transcript levels from the intestine tissue. The western bloting was used to determine the expression level occludin and ZO-1 with -actin as the reference in the intestine tissue. Asterisks indicate significant differences: * < 0.05, ** < 0.01, and *** < 0.001. | yes |
PMC11235466 | Figure_4 | oa_package/fb/83/PMC11235466.tar.gz | ['\nCranial magnetic resonance imaging on February 16, 2022.'] | Figure 4 Multiple round mixed signal shadows are detected in the right frontal lobe, temporal lobe, bilateral parieto-occipital lobe, and cerebellar hemisphere. The largest, with a size of approximately 4.6 cm 4.6 cm 5.4 cm is located in the right parietal lobe. | yes |
PMC8906555 | Figure_9 | oa_package/99/37/PMC8906555.tar.gz | ['CT angiogram showing an axial view of a large 7.'] | Figure 9 CT angiogram showing an axial view of a large 7.5 cm infrarenal abdominal aortic aneurysm with incidental bilateral renal cysts. | yes |
PMC9636768 | Figure_1 | oa_package/4a/52/PMC9636768.tar.gz | [' 1A), and then checked the SAL effect on neurites with or without the stimulation of mitochondrial toxin CCCP or A 42 oligomers.', ' 1B, D).', ' 1C, D).', 'SAL ameliorates A -induced neurite and mitochondrial damage.', '001; one-way ANOVA testNeurite injury is highly correlated to the impairment of mitochondria inside the processes.', ' 1E G).', ' 1).', ' 1), oral administration of SAL in 5 FAD mice also largely rescued cognitive defect, A pathologies and neurite morphology (Figs.', ' 1E G).'] | Fig. 1 SAL ameliorates A-induced neurite and mitochondrial damage. Schematic overview shows the workflow of SH-SY5Y differentiation and primary neuronal culture for SAL efficacy study by assessing neurite morphology and mitochondrial dynamics. Immunofluorescence (IF) of neuronal marker Tuj1 (green) in differentiated SH-SY5Y cells, treated with indicated A42 oligomers or SAL (see ). White rectangles indicate amplified images at lower panels. Scale bar, 50m. As in , except primary neurons used. Quantification of neurite length of and . The average neurite length without additional treatment was regarded as control (CTL). In each condition, at least 7 random images (each image includes20 cells) from 3 independent experiments were used for quantification. IF of TOM20 shows the mitochondrial segments in differentiated neurites of SH-SY5Y cells with indicated treatments. Scale bar, 10m. The quantification shows the length of mitochondrial (mito.) segments (n400) in , and the mitochondrial density indicating by the ratio of mito. length to occupied neurite (shaft) length (n20) in . Error bars indicate the meanSD from at least 20 neurites of 3 independent experiments. * <0.05, ** <0.01, *** <0.001; one-way ANOVA test | yes |
PMC4330237 | Figure_9 | oa_package/b9/9b/PMC4330237.tar.gz | [' 9).', 'CBCT examination combined with 3D photography.', "The image is shown with the patient's permission)\nDepending on the device used, the patient is in the standing, sitting or supine position during the CBCT examination."] | Fig. 9 CBCT examination combined with 3D photography. (Courtesy of the manufacturer. The image is shown with the patient's permission) | yes |
PMC11558494 | Figure_8 | oa_package/a7/ed/PMC11558494.tar.gz | ['Three patterns of infiltration have been described in MM (26): focal, mottled or variegated ( salt and pepper ) and diffuse; although the presence of a mixed, combined pattern is common; diffuse-multifocal ().', 'MRI patterns of multiple myeloma.'] | Figure 8 MRI patterns of multiple myeloma. (A) Sagittal FSE T1 showing nodular lesion in L4 (arrow) in relation to focal pattern, (B) sagittal FSE T1 showing diffuse infiltration of the bone marrow in the cervical vertebral bodies in relation to diffuse pattern, with superimposed osteoarthritis from C3 to C6, (C) sagittal on FSE T1 showing mottled, variegated or salt and pepper pattern; represented by diffuse micronodular lesions in the bone marrow and (D) sagittal in FSE T1 showing micronodular pattern in the vertebral bodies of the lumbar spine, similar to that observed in L4 (long date) together with diffuse infiltration of S1 (short arrow); in relation to combined-mixed pattern. MRI, magnetic resonance imaging; FSE, fast spin echo. | yes |
PMC8544166 | Figure_34 | oa_package/e3/f3/PMC8544166.tar.gz | [] | Figure 34. Lung, Infiltrate, inflammatory cell, H&E. | yes |
PMC9477053 | Figure_1 | oa_package/e3/c7/PMC9477053.tar.gz | ['\nImaging findings of a retroperitoneal mass.'] | Figure 1 A: CT scans of the abdomen demonstrates a hypodense mass in the right retroperitoneum; B: The enhanced CT shows the mass without remarkable enhancement; C: On MRI, T1-weighted image shows the mass as low signal intensity without enhancement; D: T2-weighted image shows the mass with high signal intensity. CT: Computed tomography; MRI: Magnetic resonance imaging. | yes |
PMC5994139 | Figure_5 | oa_package/24/46/PMC5994139.tar.gz | ['Expression of COL-II, ACAN, and MMP-13 protein in articular cartilage.'] | Figure 5 Expression of COL-II, ACAN, and MMP-13 protein in articular cartilage. ( ) Expression of COL-II. ( ) Expression of ACAN. ( ) Expression of MMP-13. a P<0.01 Group A; b P<0.01 Group B; c P<0.01 Group C; d P<0.01 Group D. | yes |
PMC11383359 | Figure_4 | oa_package/70/78/PMC11383359.tar.gz | ['HR and BP responses were blunted in female infarcted compared with female sham mice (, A and B).', '05; C), suggesting significantly greater sensory neural remodeling in infarcted males.', 'Consistent with decreased reflex HR responses, the percentage change in BP was also greater in infarcted females versus infarcted males (D).', 'The degree of ventricular fibrosis after MI did not significantly differ between the sexes (, E and F), suggesting that the sex differences in autonomic dysfunction could not be attributed to infarct size.', 'No differences were observed in mitochondrial OCR (Basal, ATP-linked, FCCP-induced) of the vagal ganglia of sham male versus sham female mice (Supplemental ).', 'Sex differences in in vivo optogenetic responses.'] | Figure 4 Sex differences in in vivo optogenetic responses. ( and ) In response to in vivo optogenetic vagal stimulation, female MI animals demonstrated a blunted HR and BP response compared with female sham animals ( = 6 per group). ( ) However, changes in HR were significantly different in male MI versus female MI animals ( = 6 per group) at both stimulation parameters ( < 0.01), with male animals demonstrating more diminished responses. ( ) Similar to HR, blood pressure responses to optogenetic stimulation were also reduced in infarcted males versus infarcted females (male MI versus female MI change in blood pressure at 20 Hz, 10 ms: < 0.05; change in blood pressure at 20 Hz, 20 ms: < 0.05, = 6 per group). ( and ) Myocardial fibrosis was quantified using Massons trichrome staining. Scale bar: 500 m. No difference in the degree of fibrosis between male MI and female MI mice was observed ( = 5 per group). Data are shown as mean SEM. * <0.05, ** < 0.01. BL, baseline (prestimulation); Stim, during optical stimulation. Unpaired Students test used for comparisons of males versus females. | yes |
PMC9738228 | Figure_2 | oa_package/ad/ab/PMC9738228.tar.gz | ['3A transgene decreased the eclosion rate of HD flies even further, underlining the sensitivity of the HD model to epigenetic effects (A).', '3A-expressing HD flies, but other PTM mimetic mutants did not have similar positive effects (B).', '55 days) did not deviate significantly from that of the control (C).', '3A-K9M, there was no significant difference in neurodegeneration (D).', 'K14Q modification of H3.'] | Figure 2 K14Q modification of H3.3 ameliorates HD phenotypes. ( ) Relative eclosion rates of female flies expressing or co-expressing in the nervous system. The expression of wild-type transgene decreased the eclosion rate of HD flies; thus, in all further studies, -expressing flies served as controls. The bars show the ratio of eclosed flies and error bars represent standard error. 1200, *** 0.001, Students -test. ( ) Relative eclosion rates of driven and expressing females. The eclosion rate of -expressing HD flies significantly increased, while the other modifications did not have an effect or worsened the phenotype compared with the control. The bars show the ratio of eclosed flies and the error bars represent the standard error. 1200, * 0.05, ** 0.01, ANOVA. ( ) Lifespan analysis of female flies co-expressing or in the nervous system. The median lifespan of -expressing HD flies was significantly longer, while the other modifications did not have a significant effect compared with the control. The graph shows the percentage of survivors as a function of the number of days after eclosion, 150, Fishers exact test was used for statistical analysis of the median lifespan. ( ) Pseudopupil assay of -driven -expressing 2-day-old female flies. The expression of ameliorated neurodegeneration in HD flies, while the other modifications did not have an effect or worsened the phenotype compared with the control. The bars show the average difference in rhabdomere count compared to the expressing control and the error bars represent the standard error. 10 eyes (30 ommatidia/eye), * 0.05, ** 0.01, *** 0.001, ANOVA. | yes |
PMC5102431 | Figure_10 | oa_package/f6/a0/PMC5102431.tar.gz | [] | 10.1371/journal.pone.0166006.g010 | yes |
PMC11504603 | Figure_6 | oa_package/4c/b3/PMC11504603.tar.gz | ['Kiatochwil s group evaluated\nthe diagnostic performance of [68Ga]Ga-FAPI-04 in 28 solid\ntumors, confirming its high uptake and favorable image contrast in\nseveral high-incidence tumors, such as breast cancer, lung cancer,\nesophageal cancer, liver cancer, colorectal cancer, and pancreatic\ncancer ().', '[68Ga]Ga-FAPI PET/CT in patients reflecting 15 different\nhistologically proven tumor entities.'] | Figure 6 [ Ga]Ga-FAPI PET/CT in patients reflecting 15 differenthistologically proven tumor entities. Ca = cancer; CCC = cholangiocellularcarcinoma; CUP = carcinoma of unknown primary; MTC = medullary thyroidcancer; NET = neuroendocrine tumor. [Adapted with permission fromref ( ). Copyright@ 2019 SNMMI.] | yes |
PMC10643080 | Figure_2 | oa_package/6b/32/PMC10643080.tar.gz | ['\nPostnatal imaging of the congenital infantile fibrosarcoma in Case 1.'] | Figure 2 A: One-day postnatal two-dimensional ultrasound using a linear array transducer with a frequency of 5-12 MHz, revealing a well-defined mass in the left axilla consisting mainly of isoechoic parenchymal components (*) with a few anechoic areas (white triangle) within the mass. Yellow arrow, the boundary of the mass; B: One-day postnatal pulse Doppler ultrasound revealing a rich blood flow and low resistance blood flow spectrum in the mass; C: Postnatal X-ray of the newborn showed a soft tissue density shadow protruding from the left axilla and lateral chest wall, resulting in compression of the adjacent ribs (blue arrow). White arrow, the mass on X-ray. | yes |
PMC3560699 | Figure_3 | oa_package/30/45/PMC3560699.tar.gz | ['Immunohistochemical finding was smooth muscle actin (+), pan cytokeratin ( ), HHF35 ( ), S-100 ( ), Myogenin ( ), and Vimentin (+) ().', 'Micrographs of IMT in the bladder.'] | Figure 3 Micrographs of IMT in the bladder. The visual field is filled with many spindle cells and dispersal inflammatory infiltrate ( ). The cells were positive for vimentin ( ). Original magnification 400. | yes |
PMC10591407 | Figure_6 | oa_package/94/a2/PMC10591407.tar.gz | ['db/db group\nDiscussionIn db/db mice, we investigated whether Act could protect the kidneys by decreasing podocyte apoptosis.', ' 6), indicating that Act might be a potential renoprotective agent by alleviating DKD progression.', '\nThe Act reduced the apoptosis activity of podocytes by blocking the AKT/GSK-3 signaling pathway, thus decreasing the proteinuria of db/db mice, and ameliorating DKD progression\nElectronic supplementary materialBelow is the link to the electronic supplementary material.'] | Fig. 6 The Act reduced the apoptosis activity of podocytes by blocking the AKT/GSK-3 signaling pathway, thus decreasing the proteinuria of db/db mice, and ameliorating DKD progression | yes |
PMC7526200 | Figure_1 | oa_package/ca/33/PMC7526200.tar.gz | [' 1, 2 and 3).', 'a and b High resolution Sagittal (a) and Axial T1 orbital Constructive Interference in Steady State (CISS) magnetic resonance imaging (b) prior to enucleation of left globe in a case with bilateral retinoblastoma showing a tumor mass with hemorrhage filling the posterior cavity, pushing the lens anteriorly, with optic nerve invasion beyond the lamina cribrosa.', 'c and d Early Histopathological appearance of the optic nerve (ON) in the early initially submitted routine sections with tumor cells level of ON invasion (Dotted curve line) anterior to the lamina cribrosa (c) while deeper sections obtained were showing islands of tumor cells (black arrows) invading the ON posterior to the lamina cribrosa (d) (Original magnification 200 Hematoxylin and eosin)a and b High resolution Sagittal and Axial orbital Constructive Interference in Steady State (CISS) and post contrast fat suppressed magnetic resonance imaging (a) showing invasion of the optic nerve (ON) up to 3 mm post lamina cribrosa (white arrow).'] | Fig. 1 and High resolution Sagittal ( ) and Axial T1 orbital Constructive Interference in Steady State (CISS) magnetic resonance imaging ( ) prior to enucleation of left globe in a case with bilateral retinoblastoma showing a tumor mass with hemorrhage filling the posterior cavity, pushing the lens anteriorly, with optic nerve invasion beyond the lamina cribrosa. and Early Histopathological appearance of the optic nerve (ON) in the early initially submitted routine sections with tumor cells level of ON invasion (Dotted curve line) anterior to the lamina cribrosa ( ) while deeper sections obtained were showing islands of tumor cells (black arrows) invading the ON posterior to the lamina cribrosa ( ) (Original magnification 200 Hematoxylin and eosin) | yes |
PMC6550282 | Figure_2 | oa_package/89/2e/PMC6550282.tar.gz | ['2 and Table 1, computation time scales with increasing input resolution.', 'An optimal resolution size exists considering performance vs computational time tradeoffs.', 'The optimal balance between computational burden and validation accuracy exists at 120 160 resolutionTable 1Table of evaluation results for resolution studyResolutionTraining AccuracyValidation AccuracyTraining Time / Epoch240 32094.'] | Fig. 2 An optimal resolution size exists considering performance vs computational time tradeoffs. Plot of validation accuracy and training time per epoch with input resolution. The optimal balance between computational burden and validation accuracy exists at 120160 resolution | yes |
PMC10463606 | Figure_11 | oa_package/9f/3e/PMC10463606.tar.gz | [] | Fig. 11 Effect of KYP-2047 on angiogenesis. Immunohistochemical analyses of VEGF: Sham group ( ), and BLM group ( ). KYP-2047 treatments after BLM: KYP-2047 2.5mg/kg ( ) and KYP-2047 5mg/kg ( ). See percentage of total tissue area ( ). Images were shown at 20 magnification. PulmonaryVEGF mRNA was measured by qRT-PCR ( ). Western blot analyses showed an important decrease of eNOS ( ) and CD34 ( ) expression after KYP-2047 treatments compared to BLM group. Data are representative of at least three independent experiments. One way ANOVA test **p<0.01 vs Sham; ***p<0.001 vs Sham; p<0.05 vs BLM; p<0.01 vs BLM; p<0.001 vs BLM | yes |
PMC4917394 | Figure_4 | oa_package/25/48/PMC4917394.tar.gz | ['The tumor was solitary, with no endocrine cell hyperplasia or atrophic gastritis, consistent with a type III tumor ().', '54% assigning a grade 2 neuroendocrine tumor (G2 NET) according to the world health organization (WHO) classification (D).', 'Table 1GNET characteristics, classification, and prognosis [4], [10], [25].'] | Fig. 4 (A) Insular growth pattern: Nests of monomorphous, small round neuroendocrine cells without atypia or necrosis, consistent with type III gastric neuroendocrine tumor (H&E, 200 magnification). (B) Trabecular growth pattern: Tumor cells penetrate subserosa and grow in long cords one cell thick. Cytologic atypia, mitoses and necrosis are absent. (H&E, 200 magnification). (C) Small polygonal cells with round to oval nuclei, inconspicuous nucleoli and finely dispersed chromatin. Rare mitotic figures are present. (H&E, 600 magnification). (D) Ki-67 proliferative index is 7.54%, consistent with grade 2 tumor (Ki-67, 100 magnification). | yes |
PMC9505176 | Figure_3 | oa_package/d9/d5/PMC9505176.tar.gz | ['30 nM (n = 6) (a).', '9 nM (n = 6) (a).', 'In accordance with previous reports [9,10], IR significantly increased the serum level of IL-6 (b), suggesting an inflammatory response.', 'Importantly, the chronic administration of exogenous ouabain alone did not affect serum levels of IL-6 (b).', 'Accordingly, IR also significantly increased the concentration of serum corticosterone (c), suggesting an activation of the HPA axis and increased stress response [39].', 'Chronic ouabain administration significantly reduced serum corticosterone under control conditions, but it failed to prevent IR-induced elevation in serum corticosterone level (c).', 'We found that IR significantly reduced the level of TBARS (d), suggesting the reduced level of lipid peroxidation.', 'However, the IR-induced reduction in TBARSs was not seen after ouabain administration and with a combination of IR and ouabain, the TBARS level was not significantly different from both the control group and the IR group (d).', 'Accordingly, we found elevated levels of thiol groups upon IR exposure; however, this change in thiol groups was not affected by chronic ouabain treatment (e).', 'No changes in total glutathione were seen at any intervention (f).', 'Biochemical responses to chronic administration of exogenous ouabain (OUA), ionizing radiation (IR), and their combination (OUA + IR).'] | Figure 3 Biochemical responses to chronic administration of exogenous ouabain (OUA), ionizing radiation (IR), and their combination (OUA + IR). ( ) Concentrations of ouabain, IL-6, and corticosterone measured in the blood serum, as indicated. ( ) Thiobarbituric acid reactive substance (TBARS) concentrations, ( ) the concentration of thiol groups, and ( ) total glutathione (GSH) measured in homogenates of the diaphragm muscle. The number of rats corresponds to the number of symbols. * and **, < 0.05 and 0.01 (two-way ANOVA followed by Bonferroni multiple comparisons test). | yes |
PMC3739778 | Figure_1 | oa_package/d0/90/PMC3739778.tar.gz | ['While mice at MIT developed robust typhlocolitis, mice at MHH reproducibly did not develop significant inflammation (), despite a high level colonization with H.', 'A potential attenuation of the strain 3B1 due to laboratory passage was ruled out by transfer of a fresh infectious 3B1 isolate from MIT to MHH prior to the experiment depicted in .', 'g001Effects of H.', 'To obtain the direct comparison shown in , unstained slides of samples from both facilities were exchanged and read by one pathologist who was blind to the sample identity.'] | 10.1371/journal.pone.0070783.g001 | yes |
PMC8144979 | Figure_3 | oa_package/0b/49/PMC8144979.tar.gz | ['Post-interventional CT showed a small alveolar hemorrhage along the access path and a discrete self-limiting pneumothorax ().', '(a) A 48-year-old man evaluated for suspicion of lymphoma with marked mediastinal and bilateral hilar lymphadenopathy.'] | Figure 3 ( ) A 48-year-old man evaluated for suspicion of lymphoma with marked mediastinal and bilateral hilar lymphadenopathy. The infracarinal mediastinal lymph node bulk (asterisk) was chosen for CT-guided biopsy after unsuccessful transbronchial fine-needle aspiration biopsy. ( ) Using a right paravertebral transpulmonary access under CT fluoroscopy guidance, an 18-Gauge Tru- Cut biopsy needle (arrow) was inserted into the infracarinal lymph node. Histopathology revealed a granulomatous lymphadenitis in line with sarcoidosis. ( ) Unenhanced CT after the biopsy in supine position shows a small alveolar hemorrhage along the access path (arrow) and a discrete pneumothorax. | yes |
PMC3304623 | Figure_3 | oa_package/e4/1e/PMC3304623.tar.gz | ['2 cm, the surface was smooth, and the color was dark red (A).', 'The cut section showed spongy-shaped cystic lesions beneath the capsule (B).', 'The external surface was bulging slightly (A), and a cut section showed a dark-red spongy-like soft mass beneath the capsule (B).'] | Figure 3 The external surface was bulging slightly (A), and a cut section showed a dark-red spongy-like soft mass beneath the capsule (B). | yes |
PMC5070838 | Figure_1 | oa_package/3c/12/PMC5070838.tar.gz | ['A computed tomography scan (CT) revealed a large solid, heterogeneous mass, at the level of the hyoid bone of 55 35 39 mm in size, which extended to the thyroid cartilage (, ).', '2016CT scan.', ''] | Fig. 1 CT scan. Large solid mass at the level of hyoid bone. | yes |
PMC10641521 | Figure_2 | oa_package/8e/62/PMC10641521.tar.gz | [] | Figure2 Characterization of atherosclerotic phenotype of Nrf2 and Nrf2 mice. The level of plasma cholesterol carried by LDL/VLDL lipoproteins in control healthy and atherosclerotic Nrf2 and Nrf2 mice. The level of plasma triglycerides in control healthy and atherosclerotic Nrf2 and Nrf2 mice. The staining of lipid deposits within aortic root of Nrf2 and Nrf2 mice 21 weeks after AAV8-Pcsk9 injection and HFD. The staining of lipid deposits in the brachiocephalic artery of Nrf2 and Nrf2 mice 21 weeks after AAV8-Pcsk9 injection and HFD. Lumen of the blood vessel is marked with an L. The arrows indicate lipid deposits. The number of WBC in the blood of Nrf2 and Nrf2 mice 21 weeks after AAV8-Pcsk9 injection and HFD. The percentage of monocytes in WBC population in the blood of atherosclerotic Nrf2 and Nrf2 mice 21 weeks after AAV8-Pcsk9 injection and HFD. Results are presented as mean SD. | yes |
PMC6463157 | Figure_3 | oa_package/d1/1a/PMC6463157.tar.gz | ['MR can provide a coarse estimation of the human connectome at the subjective level; shows an example of connectome generation from MR images: MR anatomical images can be segmented into several meaningful regions (the so-called brain parcellation procedure [27]), diffusion imaging provides an estimation of axonal connections linking each pair of parcels for the construction of the structural connectome matrix [28].', 'Human connectome estimation.'] | Figure 3 Human connectome estimation. The image shows an example of connectome generation from MR images: ( ) MR anatomical images can be segmented into several meaningful regions, diffusion imaging provides an estimation of axonal connections linking each pair of parcels (red tracts) for the construction of the structural connectome matrix ( ). | yes |
PMC7588445 | Figure_3 | oa_package/81/3f/PMC7588445.tar.gz | [' 3).', 'Alteration of Tip60/HDAC2 binding patterns and reduction of histone acetylation is an early event in multiple neurodegenerative disorders.', 'Drosophila larvae modelling PD and ALS neurodegenerative conditions exhibit synaptic morphological alterationsThus far, our findings demonstrated that repression of Tip60 neuroplasticity genes mediated by disruption of Tip60 HAT/HDAC2 balance is an early event in HD, PD, and ALS.', ' 3,4,6,7, wrote manuscript text, carried out experiments, analyzed results and performed statistics.'] | Figure 3 Alteration of Tip60/HDAC2 binding patterns and reduction of histone acetylation is an early event in multiple neurodegenerative disorders. Chromatin was isolated from 100 pooled larval heads for each indicated genotype under the elav pan-neuronal Gal4 driver. Control depicts elav Gal4 driver alone that is identical to respective UAS drivers alone for ALS, PD or Htt lines. . Histogram representing ChIP enrichment using the Tip60, HDAC2, H4K16Ac, H4K12Ac antibodies. All data are from three independent experiments per genotype. Fold change shown is relative to the non-specific IgG antibody control. Negative specificity control primers that amplify a heterochromatin (hc) region within chromosome 3L and primers for non-target gene specificity gene are depicted as hc and wg. Statistical significance was calculated using one-way ANOVA with Dunnetts multiple comparisons. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Error bars indicate SEM. | yes |
PMC3699922 | Figure_1 | oa_package/22/2c/PMC3699922.tar.gz | ['RESULTSThe immunohistochemical pattern of OX40, CD20, IFN- and IL-4 protein\nexpressions and their association with some clinical parameters was demonstrated on\nfigure 1.'] | FIGURE 1 Immunostaining of OX40 (A), CD20 (B), IFN- (C) and IL-4 (D) on cutaneousleishmaniasis samples. LSAB/DAB. Original magnification of 400X | yes |
PMC11566644 | Figure_1 | oa_package/23/68/PMC11566644.tar.gz | [' 1A).', ' 1B), contributing much more than other pituitary hormones (FSH, 7.', '\nSerum PRL levels were associated with MCI and decreased hippocampal volumes in T2DM patients.', ' 1C).', ' 1D).', ' 1E).', ' 1F).', ' 1G).', ' 1H).', '001; ns, not significant; two-way ANOVA (B) and one-way ANOVA (A, C-K)\nDiscussionIn this study, we revealed that PRL was associated with cognitive dysfunction and hippocampal damage in T2DM patients.'] | Fig. 1 ( ) Associations between levels of pituitary hormones and risk of MCI were adjusted for age, education, sex, smoking, SBP, FBG, FINS, FCP, HbA , HOMA-IR. ( ) Relative weight analysis of pituitary hormones in MCI prediction model. ( ) Associations between quartiles of serum PRL levels and the prevalence of MCI. ( ) Odds ratio (OR) of MCI according to quartiles of serum PRL levels were adjusted for age, education, sex, SBP, DBP, TC, HDL-C, LDL-C, FBG, HOMA-IR. Q4 is the reference group. ( ) Associations between serum PRL levels and multiple cognitive subdomains. Model 1 was unadjusted. Model 2 was adjusted for age. Model 3 was adjusted for age, education and sex. ( ) Associations between quartiles of serum PRL levels and the volumes of hippocampus after controlling for age, education, sex and TIV. ( ) An example of Freesurfer v.7.2 hippocampal segmentation with coronal. ( ) Comparisons about the volumes of hippocampal subregions (CA1, CA3, CA4, GC-DG and subiculum) between quartiles of serum PRL levels. Data are presented as the meanSD. * <0.05, ** <0.01, and *** <0.001; ns, not significant; one-way ANOVA ( , ) | yes |
PMC7563486 | Figure_8 | oa_package/b2/8c/PMC7563486.tar.gz | ['Altered genes included (i) growth factors such as nerve growth factor (Ngf) and vascular endothelial growth factor-A (Vegfa) (a), (ii) cholinergic muscarinic receptors (b), (iii) tachykinin receptors (c), (iv) pyrimidinergic (P2ry6) and purinergic receptor P2X-1 (P2rx1) (d), and (v) tyrosine hydroxylase (Th) and calcium voltage-gated channel subunit alpha1-C (Cacn 1c) (e).', 'In particular, bladder expression of genes associated with mediating contractile stimuli of the detrusor muscle, including cholinergic receptor muscarinic-2 (Chrm2), -3 (Chrm3), and -5 (Chrm5), were increased in the DM group but decreased by M-MSC transplantation (b).', 'The significant decrease in detrusor volume in our diabetic model might result in over-expression of receptors associated with detrusor contraction to maintain contraction (b d); however, alteration in the function of these receptors should be evaluated further.', 'In addition, the Ngf transcript level was downregulated in our diabetic model but was not restored to a significant level in one week after M-MSC transplantation (a).', 'M-MSC therapy restored expression of genes related to diabetic DUA (a e) RQ-PCR measurement of mRNA levels for genes related to the pathogenesis of diabetic DUA in the bladders of DM rats at 1 week after injection of M-MSCs or PBS.'] | Figure 8 M-MSC therapy restored expression of genes related to diabetic DUA ( ) RQ-PCR measurement of mRNA levels for genes related to the pathogenesis of diabetic DUA in the bladders of DM rats at 1 week after injection of M-MSCs or PBS. These genes included ( ) growth factors such as Nerve growth factor ( ) and Vascular endothelial growth factor-A ( ), ( ) cholinergic muscarinic receptors, ( ) tachykinin receptors, ( ) Pyrimidinergic receptor ( ) and Purinergic receptor P2X-1 ( ), and ( ) tyrosine hydroxylase ( ) and calcium voltage-gated channel subunit alpha1-C ( ). Expression levels of the indicated transcripts are presented as % . Expression levels ( = 5 animals/group) are presented as means SEM. (* < 0.05, ** < 0.01, and *** < 0.001 relative to DM group, one-way ANOVA). | yes |
PMC5704819 | Figure_2 | oa_package/c3/4b/PMC5704819.tar.gz | ['The fetal bladder wall was thickened (arrow).'] | Figure 2 The fetal bladder wall was thickened (arrow). | yes |
PMC4754353 | Figure_3 | oa_package/39/a7/PMC4754353.tar.gz | ['Indeed, endogenous GlyRSWT was detected in the culture media of mouse motor neuron and differentiated myotube cell lines, but not of undifferentiated myoblasts (Extended Data a e).', 'Extracellular levels of GlyRSWT were diminished by application of the exosome-pathway inhibitor GW4869 and enhanced by exosome-pathway activators monensin (Extended Data a f).', 'Our results showed that P234KY-GlyRSCMT2D was detected at levels similar to GlyRSWT in the media of transfected cells (Extended Data g).', 'At 4 weeks, CMT2D-like symptoms including overt neuromuscular dysfunction and an altered walking stride become apparent in GarsCMT2D mutants, whereas Nrp1+/ mice appeared normal (a d and Supplementary Video 1, 2).', 'Strikingly, by 4 weeks, 50% of the GarsCMT2D/Nrp1+/ mutant mice had entirely lost the ability to spread their legs and toes (a and b), and exhibited severely abnormal gait patterns (', '2a), intercrosses between GarsCMT2D and TrkB+/ , DCC+/ , Robo1+/ and Unc5C+/ heterozygous mice did not worsen the neuromusclular phenotypes in the compound heterozygotes (b and Extended Data ', 'Neuromuscular junctions (NMJs) displayed a normal apposition of nerve fibers and post-synaptic acetylcholine receptors in wild-type (WT) and Nrp1+/ animals, while partially innervated and completely denervated NMJs were present in 4-week GarsCMT2D mutants (e, f).', 'The loss of nerve terminals at NMJs was markedly increased in GarsCMT2D/Nrp1+/ mutants (e, f).', 'Likewise, at 4 weeks of age many large-diameter axons were absent from the sciatic nerves of GarsCMT2D mutants compared to WT and Nrp1+/ littermates (g, h and Extended Data ', 'The absence of large diameter axons was even more dramatic in 4-week GarsCMT2D/Nrp1+/ compound mutants, and was comparable to the extreme axonal dystrophy observed in late-stage CMT2D mutants (g, h and Extended Data ', 'Exosome purification and analysisThe general idea of exosome purification by differential centrifugation is depicted in Extended Data a.', 'Extended Data Detection of GlyRS proteins in the cell mediuma, c, e, Western-blot analysis of the GlyRS protein levels in NSC34 motor neurons (a), C2C12 cell-differentiated myotubes (c) and undifferentiated C2C12 myoblasts (e).', 'Nrp1 is a genetic modifier of CMT2Da, b, Hindlimb extension test at 4 weeks.'] | Extended Data Figure 3 Detection of GlyRS proteins in the cell medium , Western-blot analysis of the GlyRS protein levels in NSC34 motor neurons ( ), C2C12 cell-differentiated myotubes ( ) and undifferentiated C2C12 myoblasts ( ). The level of GlyRS proteins in cell medium is diminished by application of the exosome-pathway inhibitor GW4869, but not by Brefeldin A (BFA), an inhibitor of the classical endoplasmic reticulum (ER) to Golgi secretory pathway. GAPDH (cytoplasmic protein), vWF (secretory protein through ER-Golgi pathway) and TSG101 (Exosomal protein) are used as controls. , Quantification of GlyRS protein level indicated in . Data are presented as the mean SEM of three independent experiments (*p < 0.05, t-test). , Western-blot analysis of the GlyRS protein level in NSC34 motor neurons. The level of GlyRS proteins in the cell medium is increased by the treatment of monensin (MON), an activator for microvesicle release by regulating the intracellular calcium level . Vehicle-treated cells were used as control (Ctrl). , Western-blot analysis of the GlyRS protein level in Cos7 cells transfected with plasmids encoding GlyRS and P234KY-GlyRS . The expression of GlyRS proteins was detected by immuno-blot with antibody to V5 epitope tag. GAPDH was used as control. Note the similar level of GlyRS and GlyRS in the media of transfected Cos7 cells. The observation that differentiated myotubes also secret GlyRS raises the possibility that muscles, which are directly innervated by the peripheral motor neurons, might contribute to the disease pathology. | yes |
PMC9374177 | Figure_3 | oa_package/2f/02/PMC9374177.tar.gz | ['Cerebral angiogram.'] | Figure 3 Cerebral angiogram. This is an angiogram that illustrates occlusion of the supraclinoid segment of the left internal carotid artery. The arrow points to the area of stenosis and the subsequent vessels have the smoke-like appearance of moyamoya disease. | yes |
PMC10515769 | Figure_3 | oa_package/14/78/PMC10515769.tar.gz | ['Spatially-informed Subpopulation Analysis Reveals Cellular Heterogeneity in ADTo illustrate the ST data analysis workflow and functions that are available to users of ssREAD, we used two ST data (ST01101 and ST01103), labeled by six cortical layers and the adjacent white matter in two human middle temporal gyrus (MTG) brain samples based on the information provided in the original study14 (A).', 'Further implementation of RESEPT15, a deep-learning framework for spatial domain detection, provided a precise delineation of the tissue architecture and functional zones in both control and AD brain tissues (B).', 'Moreover, the potential of ssREAD in navigating the complex spatial information of AD was further exemplified through a multi-dimensional exploration of spatially informed sub-populations via MAPLE19 (C).', 'To further illuminate these cellular dynamics, we mapped the MAPLE cluster annotations in individual samples to their corresponding layer annotations (D, Supplementary ', 'At the molecular level, we identified DEGs in each MAPLE cluster (E and Source Data 2) and between control and AD samples within individual MAPLE clusters (', 'The expression pattern of these DEGs underscores the molecular heterogeneity in MAPLE clusters (subpopulations) and between AD and the control (F).', 'Interestingly, all five downregulated pathways are associated with immune responses/functions (G), which may highlight the important role of immune cells in AD pathogenesis24 27.', 'Besides DEGs and DEG enriched pathways, we also identified 305 SVGs in cluster 5, such as PLP1 and UCHL1 (H), which show clear spatial expression patterns that are linked to specific tissue layers.', 'Further dissection of these TFs showed differences in TF activities between control and AD samples, for example, ATF6 and EGR1 (I).', 'Unfortunately, we observed a very low proportion of the microglia cell type in both Visium samples (Supplementary B).', '556944v2-f0002" position="float"/>.'] | Fig. 3. Multi-dimensional analysis of spatially-informed sub-populations. (A) Annotation of the six cortical layers alongside the adjacent white matter within two human middle temporal gyrus (MTG) brain samples (ST01101 and ST01103). (B) Detection of spatial domains by RESEPT. (C) Visualization using MAPLE to elucidate shared or unique spatial domains identified across the two Spatial Transcriptomics samples (ST01101 and ST01103). (D) Alluvial diagrams showcasing the progression of cells: originating from individual samples, aggregating into joint subpopulations, and culminating in layer annotations. (E) A heatmap depicting genes specific to the MAPLE-derived clusters for both AD and Control samples. (F) Heatmap representing the top 10 upregulated and top 10 downregulated genes distinguishing AD from Control within Cluster 1. (G) Gene Set Enrichment Analysis (GSEA) of DEGs from (E) plotted against REACTOME pathways. The bar plot shows the top 10 upregulated and downregulated pathways, accompanied by normalized enrichment scores. (H) Spatial feature plots highlighting the variance in gene expression of and from Cluster 1, segregated by AD and Control samples. (I) Violin plots showcasing the activity of two selected TFs between AD and Control, with associated -values calculated from a two-sided Wilcoxon rank-sum test. Each box showcases the minimum, first quartile, median, third quartile, and maximum ARI results of a tool performed on different data subsets (Control group: n = 232, and AD group: n = 1,412). Dots represent spatial spots. Source data are provided as a Source Data file. | yes |
PMC10493587 | Figure_3 | oa_package/09/4a/PMC10493587.tar.gz | ['CD301+ macrophages activate GAS6/AXL signaling to promote SMA and Collagen 1 expression in hESCs\nThe volcano plot of genes between CD301b+ macrophages and F4/80 immune cells based on the reanalysis of a published dataset (GSE105789).', 'Source Data for <media xlink:href="EMMM-15-e17601-s007.'] | Figure 3 CD301 macrophages activate GAS6/AXL signaling to promote SMA and Collagen 1 expression in hESCs Data information: Scale bar: 100m. Data are presented as meanSEM. (CE) Twotailed Student's test. (FI) Oneway ANOVA with Tukey's analysis. * <0.05; ** <0.01; *** <0.001. NS, not significant. | yes |
PMC2725755 | Figure_4 | oa_package/7c/2d/PMC2725755.tar.gz | [] | Figure4 A working model of the key steps in the induction and effector pathways of Treg cell activation, expansion and suppressive function to mediate maternalfetal tolerance. The sequence of events includes (1) antigen uptake and processing within tolerogenic DCs; (2) trafficking of DCs to draining lymph nodes and presentation of antigen fragments on the surface of the DC in association with MHC molecules; (3) interaction between the DC and Treg cells expressing cognate TCRs in the presence of IL-2 and/or IL-15 to elicit their activation and proliferation; (4) recruitment of Treg cell populations from the maternal circulation into the decidual tissue mediated by CCL4 and (5) exertion of specific effector functions, including secretion of IL-10 and TGF, and inducing IDO expression in target DCs to further activate and maintain suppressive function in Treg cells, inhibit Th1 cell proliferation and induce Th1 cell apoptosis. Specific cytokines including TGF, GM-CSF, IL-4, IL-10, G-CSF and prostaglandin E known to predominate the uterine cytokine milieu are identified as regulators of tolerogenic DCs. Ag, antigen; CCL4, chemokine (CC motif) ligand 4; DC, dendritic cell; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IDO, indoleamine 2,3-dioxygenase; IL, interleukin; MHC, major histocompatibility complex; TGF, transforming growth factor. | yes |
PMC8222021 | Figure_5 | oa_package/ec/fd/PMC8222021.tar.gz | [' 5a and c.', ' 5b).', ' 5d).', 'Real-time PCR analysis and western blot analysis.', '05 # vs CTR, * vs CTR + LASER, vs HCC, vs HCC + LASER, $ vs HHA, vs HHA + LASER for each of the 6 families compared (tables in supplementary files)DiscussionScratch assay is a consolidated practice in our laboratory and TLVM helps not only to empirically follow biological phenomena but also to quantify some of those.'] | Fig. 5 Real-time PCR analysis and western blot analysis. Relative integrin V gene expression from HaCaT irradiated with laser and after treatment with HCC and HHA. Integrin V protein expression level and densitometric results were normalized in respect to actin. All values were expressed in the form of mean SD ( =3). Relative integrin 3 gene expression from HaCaT irradiated with laser and after treatment with HCC and H-HA. Integrin 3 protein expression level and densitometric results were normalized in respect to actin. All values were expressed in the form of mean SD ( =3). Results were considered significantly different for tukey<0.05 # vs CTR, * vs CTR+LASER, vs HCC, vs HCC+LASER, $ vs HHA, & vs HHA+LASER for each of the 6 families compared (tables in ) | yes |
PMC5758264 | Figure_5 | oa_package/3b/6a/PMC5758264.tar.gz | ['MIP image of an 84-year-old female with DLBCL on chemotherapy.'] | Figure 5 MIP image of an 84-year-old female with DLBCL on chemotherapy. PET/CT was performed at an outside institution after completion of treatment. The initial report indicated diffuse bone marrow uptake suspicious for lymphomatous involvement (stage IV). Second-opinion review at our institution described the diffuse bone marrow uptake as reactive to endogenous and/or exogenous stimulation. Therefore, the PET/CT was reported as no evidence of disease, concordant with the bone marrow biopsy and the multidisciplinary staging as complete remission. | yes |
PMC6898930 | Figure_3 | oa_package/a6/e5/PMC6898930.tar.gz | [' 3a) [15].', ' 3b).'] | Fig. 3 Spectral domain optical coherence tomographic (SD-OCT) images of both eyes in patient 1 (A) and patient 2 (B) showed: foveal hypoplasia, decreased reflectivity of the EZ-band, indistinct ELM and presence of hyporeflective area underneath the EZ-band foveal hypoplasia | yes |
PMC8340373 | Figure_2 | oa_package/79/2e/PMC8340373.tar.gz | [' 2).', 'pulmonary artery (PA), right pulmonary artery (RPA) and left pulmonary artery (LPA), right ventricle outflow tract (RVOT)The second one, was a large mass measuring 28 mm 22 mm in the right atrium.'] | Fig. 2 Parasternal short axis view at the level of the aortic valve. Asterisk showing the obstructive mass in the RVOT. pulmonary artery (PA), right pulmonary artery (RPA) and left pulmonary artery (LPA), right ventricle outflow tract (RVOT) | yes |
PMC5094992 | Figure_6 | oa_package/b7/c8/PMC5094992.tar.gz | ['Rapamycin significantly reversed the effect of AIM2-deficiency on HCC cellsHepG2 cells and BEL7402 cells were transfected with siRNA targeting AIM2 before treatment with mTOR-S6K1 pathway inhibitor rapamycin (100 nM) for 24 h.'] | Figure 6 Rapamycin significantly reversed the effect of AIM2-deficiency on HCC cells HepG2 cells and BEL7402 cells were transfected with siRNA targeting AIM2 before treatment with mTOR-S6K1 pathway inhibitor rapamycin (100 nM) for 24 h. ( ) CCK8 assay was performed to detect the proliferation status of the treated cells at 0 h, 24 h, 36 h, 48 h and 72 h (A for HepG2 cells and B for BEL7402 cells). *** < 0.001 for comparison of si-AIM2 transfected cells with and without rapamycin treatment. ( ) Colony formation assay was performed to detect the effect of rapamycin on the si-AIM2 transfected HCC cells. ( ) Transwell assay was used to determine the effect of rapamycin on the invasive capability of si-AIM2 transfected cells. * < 0.05, ** < 0.01 for comparison between indicated groups. | yes |
PMC10694404 | Figure_5 | oa_package/24/fe/PMC10694404.tar.gz | ['.'] | Figure 5. ( ) 19 germline differentially methylated regions (gDMRs) were profiled for their methylation pattern in five ovarian support cell maturation (IVM) (OSC-IVM) Day 5 or 6 euploid blastocysts and eight donated Day 5 or 6 euploid blastocysts after conventional ovarian stimulation (COS). Additional control data were obtained from for biphasic IVM (CAPA-IVM) and COS samples. Symbols represent gDMR percentages of individual embryos. Data are plotted as median with error bars representing 95% confidence interval (CI). Statistical significance testing was performed using one way analysis of variance (ANOVA) with multiple comparisons testing for analysis comparison to the external reference COS control. ( ) Whole genome methylation analysis of 5-methylcytosine (5mC) levels for the five OSC-IVM blastocysts and eight donated COS blastocyst controls. Statistical significance testing was performed using two-way unpaired -test comparison to the internal reference COS control. | yes |
PMC10348507 | Figure_3 | oa_package/1e/56/PMC10348507.tar.gz | ['Single-photon emission computed tomography-computed tomography (SPECT-CT) of the feet localizes this significantly increased uptake to be within the left navicular bone (NB) that appears to be flattened, sclerotic, and fragmented on the CT component [].', 'ijnm_187_22-f003">(a) Coronal, sagittal, and transaxial single-photon emission computed tomography images show a single focus of increased uptake at the area of the navicular bone.'] | Figure 3 (a) Coronal, sagittal, and transaxial single-photon emission computed tomography images show a single focus of increased uptake at the area of the navicular bone. (b) Noncontrast computed tomography in coronal, sagittal, and transaxial cuts shows flattened, sclerotic, and fragmented navicular bone and arrows. (c) Fused images show this increased uptake to be within the navicular bone and arrows | yes |
PMC9547428 | Figure_4 | oa_package/f0/4f/PMC9547428.tar.gz | [' 4a).', ' 4b c).', ' 4e f), while the -diversity index (Chao1, ACE, Simpson, and Shannon based on OUT level) did not vary significantly among the four treatment groups (Additional file 1: ', ' 4e f).', 'Nasal instillation of MSNs-Bi reduced intestinal inflammation and shaped gut microbiota.', 'h A 42 levels in the stomach, duodenum, jejunum, ileum, cecum, and colon of APP/PS1 mice treated with PBS, MSNs, Bifidobacterium, and MSNs-BiTo further evaluate the effect of different treatments on intestinal soluble A , tissue grinding and sectioning were performed on the intestines of the above-treated mice.', ' 4g, Additional file 1: ', ' 4h), a finding consistent with the results of ThioS-stained intestinal tissue fluorescence imaging.', ' 4g h).', ' 4d).', ' 4, 5).', ' 4b f).'] | Fig.4 Nasal instillation of MSNs-Bi reduced intestinal inflammation and shaped gut microbiota. Schematic diagram of MSNs-Bi treatment of 4month-old APP/PS1 mice; n=3. Representative hematoxylin and eosin-stained images of colon tissues from APP/PS1 mice after treatment with PBS, MSNs, , and MSNs-Bi; Bi refers to , scale bars=100m. Crypt length of colon tissues from APP/PS1 mice treated with PBS, MSN, , and MSNs-Bi. SCFAs levels in feces of APP/PS1 mice treated with PBS, MSNs, MSNs-Bi, and . Composition of the gut microbiome of APP/PS1 mice treated with PBS, MSNs, , and MSNs-Bi. The Y-axis represents the relative abundance of genus-level gut microbial taxa. abundance (log2 transformed) in the gut microbiome of C57BL/6J mice (WT) and APP/PS1 mice treated with PBS, MSNs, , and MSNs-Bi. Representative images of ThioS staining of the gut of APP/PS1 mice after treatment with PBS, MSNs, , and MSNs-Bi; scale bars=100m. A levels in the stomach, duodenum, jejunum, ileum, cecum, and colon of APP/PS1 mice treated with PBS, MSNs, , and MSNs-Bi | yes |
PMC10385677 | Figure_2 | oa_package/7c/dd/PMC10385677.tar.gz | ['In our calculations of prednisone equivalent dosage, we excluded one patient with PV (#1) () who, due to contraindications (active hepatitis C viremia treated with glecaprevir/pibrentasvir), could not start GCS.', 'A noteworthy 69-year-old patient with cutaneous PV (#1), in whom the value of IgG antibodies to desmoglein 3 with multiplex ELISA at the time of diagnosis was highly elevated 5.'] | Figure 2 A noteworthy 69-year-old patient with cutaneous PV (#1), in whom the value of IgG antibodies to desmoglein 3 with multiplex ELISA at the time of diagnosis was highly elevated 5.50 (cut-off value = 1). Erosions covered with necrotic crusts on the frontal-parietal surface of the head ( ). Suprabasilar separation with acantholytic keratinocytes seen in H + E histology (original objective magnification 20) ( ). IgG4 (++) pemphigus deposits with DIF visualized using a short-arc mercury-lamp-operated microscope (original objective magnification 40) ( ). Despite a complete clinical remission after IVIG therapy, the value of IgG antibodies to desmoglein 3 was still elevated (value 3.75) at follow-up 17 months after the diagnosis. | yes |
PMC5975524 | Figure_3 | oa_package/d5/fc/PMC5975524.tar.gz | [' 3a and b respectively).', '3c and d respectively).', 'High and low density of TILs in ovarian tumors.', 'Distribution of CD8 T cells in clusters and as single cells is apparent in c and d respectivelyDistribution of FoxP3 expressing T regulatory cells in ovarian tumors.'] | Fig. 3 High and low density of TILs in ovarian tumors. IHC staining of T cell subsets in patients FFPE tissue sections. CD3 exhibiting diffuse strong staining in clusters of tumor infiltrating lymphocytes ( ) versus focal staining in scattered TILs in less dense areas ( ). Distribution of CD8 T cells in clusters and as single cells is apparent in and respectively | yes |
PMC6946346 | Figure_1 | oa_package/46/12/PMC6946346.tar.gz | ['Computed tomography (CT) scan.'] | Figure 1 Computed tomography (CT) scan. Inhomogeneous mass tightly attached to the right (white arrow) and sigmoid colon (black arrow). | yes |
PMC10502948 | Figure_5 | oa_package/24/9f/PMC10502948.tar.gz | ['Notably, BV-LPS treatment was able to reverse these changes (A and B).', '.'] | Figure 5. The TLR4/BAMBI/Snail pathway may be involved in BV-LPS abolished EC-LPS induced EMT. The (A) immunohistochemical and (B) reverse transcription-quantitative PCR showed that BV-LPS could reverse the downregulation of E-cadherin and upregulation of -SMA and vimentin induced by EC-LPS (scale bar, 50 m). ***P<0.001 vs. the control group; P<0.05, P<0.01 and P<0.001 vs. the EC-LPS group. TLR4, Toll-like receptor 4; BAMBI, bone morphogenic protein and activin membrane-bound inhibitor; BV-LPS, LPS extracted from ; EC-LPS, LPS extracted from ; EMT, epithelial-mesenchymal transition; -SMA, -smooth muscle actin; Control, control group; EC, EC-LPS group; BV, BV-LPS group; EC-BV, co-treated with EC-LPS and BV-LPS group. | yes |
PMC4512158 | Figure_3 | oa_package/06/c7/PMC4512158.tar.gz | [' 3e and f).', 'Gross and microscopic changes associated with acute metallic phosphide poisoning in the brain and lungs.', 'a Brain, acute, diffuse meningeal congestion; (b) Brain, at the level of the telencephalon, small sized blood vessels are congested and there is mild gliosis (H E stain, original magnification 100X); (c) Brain, an area of hemorrhage is observed (H E stain, original magnification 200X), The inset shows a viable neuron with presence of Nissl substance (Cresyl violet stain, original magnification 1000X); (d) Lung, grossly, acute severe, diffuse pulmonary congestion, edema and multifocal petechial to ecchymotic hemorrhages are visible on the surface; (e) Lung, alveoli, congestion and hemorrhage with thickening of interalveolar septa (H E stain, original magnification 200X); (f) Lung, severe, diffuse, alveolar congestion, edema and multifocal haemorrhage (H E stain, original magnification 100X)The toxicological examination confirmed the presence of the phosphine gas in the gastric content and in the bait.'] | Fig. 3 Gross and microscopic changes associated with acute metallic phosphide poisoning in the brain and lungs. Brain, acute, diffuse meningeal congestion; ( ) Brain, at the level of the telencephalon, small sized blood vessels are congested and there is mild gliosis (H&E stain, original magnification 100X); ( ) Brain, an area of hemorrhage is observed (H&E stain, original magnification 200X), The inset shows a viable neuron with presence of Nissl substance (Cresyl violet stain, original magnification 1000X); ( ) Lung, grossly, acute severe, diffuse pulmonary congestion, edema and multifocal petechial to ecchymotic hemorrhages are visible on the surface; ( ) Lung, alveoli, congestion and hemorrhage with thickening of interalveolar septa (H&E stain, original magnification 200X); ( ) Lung, severe, diffuse, alveolar congestion, edema and multifocal haemorrhage (H&E stain, original magnification 100X) | yes |
PMC8696051 | Figure_5 | oa_package/a2/60/PMC8696051.tar.gz | [' demonstrates the postoperative images of radiography and CT scan of in-situ lateral mass screw.', 'Postoperative image of X-ray (A, B) and computed tomography scan (C H) of in-situ lateral mass screw.'] | Fig. 5 Postoperative image of X-ray and computed tomography scan of lateral mass screw. | yes |
PMC9515104 | Figure_8 | oa_package/bc/77/PMC9515104.tar.gz | [' 8.', ' 8.', ' 8 also shows that some misclassified patches are located on the white WSI background.', 'Exemplary classification results.', 'To evaluate whether some tumor subtypes were more difficult for the classification network than others, i.', ' 8 shows a melanoma sample where the majority voting yielded the correct classification label but was affected by many false patch classifications.', ' 8 reveals that this can be rooted back to a false tumor prediction of the preceding segmentation network, as only the area correctly classified as melanoma was also annotated as tumor.'] | Fig. 8 Exemplary classification results. The upper example shows a trichoblastoma sample misclassified as melanoma with the classification output on the left and the magnified tumor region on the right. The tumor region shows a high number of pleomorphic tumor cells. The lower example shows a melanoma sample with the classification output on the left and the annotated sample on the right. The classification output shows a high ratio of misclassified patches caused by a false tumor prediction during segmentation. MCT: mast cell tumor, SCC: squamous cell carcinoma, PNST: peripheral nerve sheath tumor. | yes |
PMC7545988 | Figure_1 | oa_package/92/e3/PMC7545988.tar.gz | ["AbbreviationsBMSBasso mouse scaleCSF1Rcolony-stimulating factor 1 receptorCAcornu AmmonisDAPI4',6-diamidino-2-phenylinodoleDGdentate gyrusDEdifferentially expressedERendoplasmic reticulumFSforced swim testIACUCInstitutional Animal Care and Use CommitteeIHCimmunohistochemistryLFBLuxol fast blueNORNovel object recognitionOFopen fieldSPsucrose preferenceSWMspared white matterTStail-suspensionPOposterior thalamic nucleusPLXPlexxikonPPIprotein-protein interactionPCAprincipal component analysisPC1principle componentROSreactive oxygen speciesSCIspinal cord injuryVPLventral posterolateral nucleusVPMventral posteromedial nucleus1AbramsonCEMcBrideKEKonnyuKJElliottSLTeamSRSexual health outcome measures for individuals with a spinal cord injury: a systematic reviewSpinal cord2008463204\n179386402PersuCCaunVDragomiriteanuIGeavletePUrological management of the patient with traumatic spinal cord injuryJ Med Life20092296302\n201124743SiddallPJMcClellandJMRutkowskiSBCousinsMJA longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injuryPain200310324957\n127914314StormerSGernerHJGruningerWMetzmacherKFollingerSWienkeCChronic pain/dysaesthesiae in spinal cord injury patients: results of a multicentre studySpinal cord19973544655\n92327505Widerstrom-NogaEGFelixERCruz-AlmeidaYTurkDCPsychosocial subgroups in persons with spinal cord injuries and chronic painArchives of physical medicine and rehabilitation200788162835\n180478786SachdevaRGaoFChanCCHKrassioukovAVCognitive function after spinal cord injury: A systematic reviewNeurology20189161121\n301581597HuangSWWangWTChouLCLiouTHLinHWRisk of Dementia in Patients with Spinal Cord Injury: A Nationwide Population-Based Cohort Study\nJ Neurotrauma2016\n8LazzaroITranYWijesuriyaNCraigACentral correlates of impaired information processing in people with spinal cord injuryJournal of clinical neurophysiology: official publication of the American Electroencephalographic Society2013305965\n233774449MurrayRFAsghariAEgorovDDRutkowskiSBSiddallPJSodenRJImpact of spinal cord injury on self-perceived pre- and postmorbid cognitive, emotional and physical functioningSpinal cord20074542936\n1722835510CraigAGuestRTranYMiddletonJCognitive Impairment and Mood States after Spinal Cord InjuryJ Neurotrauma201734115663\n2771729511Arango-LasprillaJCKetchumJMStarkweatherANichollsEWilkARFactors predicting depression among persons with spinal cord injury 1 to 5 years post injuryNeuroRehabilitation201129921\n2187629112de CarvalhoSAAndradeMJTavaresMAde FreitasJLSpinal cord injury and psychological responseGeneral hospital psychiatry1998203539\n985464713LuedtkeKBouchardSMWollerSAFunkMKAcevesMHookMAAssessment of depression in a rodent model of spinal cord injuryJ Neurotrauma201431110721\n2456423214WuJStoicaBALuoTSabirzhanovBZhaoZGuancialeKIsolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment: Involvement of cell cycle activation\nCell Cycle201413\n15WuJZhaoZKumarALipinskiMMLoaneDJStoicaBAEndoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury\nJ Neurotrauma2016\n16WuJZhaoZSabirzhanovBStoicaBAKumarALuoTSpinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathwaysJ Neurosci201434109891006\n2512289917Maldonado-BouchardSPetersKWollerSAMadahianBFaghihiUPatelSInflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injuryBrain Behav Immun20165117695\n2629656518HausmannONPost-traumatic inflammation following spinal cord injurySpinal cord20034136978\n1281536819TatorCHFehlingsMGReview of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanismsJ Neurosurg1991751526\n204590320HouleJDCoteMPAxon regeneration and exercise-dependent plasticity after spinal cord injuryAnn N Y Acad Sci2013127915463\n2353101321SiddiquiAMKhazaeiMFehlingsMGTranslating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injuryProgress in brain research20152181554\n2589013122WuJRaverCPiaoCKellerAFadenAICell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusionNeurotherapeutics20131052038\n2377506723ZhaoPWaxmanSGHainsBCModulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21J Neurosci2007278893902\n1769967124JureIPietraneraLDe NicolaAFLabombardaFSpinal Cord Injury Impairs Neurogenesis and Induces Glial Reactivity in the HippocampusNeurochem Res201742217890\n2829013525XueWKZhaoWJMengXHShenHFHuangPZSpinal cord injury induced Neuregulin 1 signaling changes in mouse prefrontal cortex and hippocampusBrain research bulletin20191441806\n3052936726AllisonDJDitorDSTargeting inflammation to influence mood following spinal cord injury: a randomized clinical trialJ Neuroinflammation201512204\n2654536927BowesALYipPKModulating inflammatory cell responses to spinal cord injury: all in good timeJ Neurotrauma201431175366\n2493460028PlemelJRWee YongVStirlingDPImmune modulatory therapies for spinal cord injury-past, present and futureExp Neurol201425891104\n2501789029JohnsonVEStewartJEBegbieFDTrojanowskiJQSmithDHStewartWInflammation and white matter degeneration persist for years after a single traumatic brain injuryBrain20131362842\n2336509230LoaneDJKumarAStoicaBACabatbatRFadenAIProgressive neurodegeneration after experimental brain trauma: association with chronic microglial activationJ Neuropathol Exp Neurol2014731429\n2433553331MouzonBCBachmeierCFerroAOjoJOCrynenGAckerCMChronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury modelAnn Neurol20147524154\n2424352332Nagamoto-CombsKMcNealDWMorecraftRJCombsCKProlonged microgliosis in the rhesus monkey central nervous system after traumatic brain injuryJ Neurotrauma200724171942\n1800120233RamlackhansinghAFBrooksDJGreenwoodRJBoseSKTurkheimerFEKinnunenKMInflammation after trauma: microglial activation and traumatic brain injuryAnn Neurol20117037483\n2171061934ByrnesKRWashingtonPMKnoblachSMHoffmanEFadenAIDelayed inflammatory mRNA and protein expression after spinal cord injuryJ Neuroinflammation20118130\n2197506435GinhouxFGreterMLeboeufMNandiSSeePGokhanSFate mapping analysis reveals that adult microglia derive from primitive macrophagesScience20103308415\n2096621436ErblichBZhuLEtgenAMDobrenisKPollardJWAbsence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficitsPLoS One20116e26317\n2204627337ElmoreMRNajafiARKoikeMADagherNNSpangenbergEERiceRAColony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brainNeuron20148238097\n2474246138RiceRASpangenbergEEYamate-MorganHLeeRJAroraRPHernandezMXElimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the HippocampusJ Neurosci201535997789\n2615699839DagherNNNajafiARKayalaKMElmoreMRWhiteTEMedeirosRColony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD miceJ Neuroinflammation201512139\n2623215440AcharyaMMGreenKNAllenBDNajafiARSyageAMinasyanHElimination of microglia improves cognitive function following cranial irradiationScientific reports2016631545\n2751605541WalterTJCrewsFTMicroglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawalJ Neuroinflammation20171486\n2842742442SpangenbergESeversonPLHohsfieldLACrapserJZhangJBurtonEASustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease modelNat Commun2019103758\n3143487943Bellver-LandeteVBretheauFMailhotBVallieresNLessardMJanelleMEMicroglia are an essential component of the neuroprotective scar that forms after spinal cord injuryNat Commun201910518\n3070527044GerberYNSaint-MartinGPBringuierCMBartolamiSGoze-BacCNoristaniHNCSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord InjuryFrontiers in cellular neuroscience201812368\n3038621245EvansTABarkauskasDSMyersJTHareEGYouJQRansohoffRMHigh-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injuryExp Neurol201425410920\n2446847746NordenDMFawTDMcKimDBDeibertRJFisherLCSheridanJFBone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord InjuryJ Neurotrauma20193693749\n3001476747PopovichPGGuanZWeiPHuitingaIvan RooijenNStokesBTDepletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injuryExp Neurol199915835165\n1041514248ZhuYSoderblomCKrishnanVAshbaughJBetheaJRLeeJKHematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injuryNeurobiol Dis20157411425\n2546125849LeeSMRosenSWeinsteinPvan RooijenNNoble-HaeussleinLJPrevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injuryJ Neurotrauma2011281893907\n2165785150FengXValdearcosMUchidaYLutrinDMazeMKoliwadSKMicroglia mediate postoperative hippocampal inflammation and cognitive decline in miceJCI Insight20172e91229\n2840562051ValdearcosMDouglassJDRobbleeMMDorfmanMDStiflerDRBennettMLMicroglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity SusceptibilityCell metabolism20172618597e3\n2868328652ZhouKZhengZLiYHanWZhangJMaoYTFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stressTheranostics2020109280302\n3280219253YaoYXuJYuTChenZXiaoZWangJFlufenamic acid inhibits secondary hemorrhage and BSCB disruption after spinal cord injuryTheranostics20188418198\n3012804654RitzelRMLiYHeJKhanNDoranSJFadenAISustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injuryNeurobiol Dis2020136104713\n3184370555RitzelRMAl MamunACrapserJVermaRPatelARKnightBECD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after strokeJ Neuroinflammation20191640\n3077709356BassoDMFisherLCAndersonAJJakemanLBMcTigueDMPopovichPGBasso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strainsJ Neurotrauma20062363559\n1668966757WuJSabirzhanovBStoicaBALipinskiMMZhaoZZhaoSAblation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injuryCell Cycle2015143698712\n2650508958HenryRJRitzelRMBarrettJPDoranSJJiaoYLeachJBMicroglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological DeficitsJ Neurosci202040296074\n3209420359VandesompeleJDe PreterKPattynFPoppeBVan RoyNDe PaepeAAccurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesGenome biology20023RESEARCH0034\n1218480860WangHHorbinskiCWuHLiuYShengSLiuJNanoStringDiff: a novel statistical method for differential expression analysis based on NanoString nCounter dataNucleic Acids Res201644e151\n2747103161SzklarczykDGableALLyonDJungeAWyderSHuerta-CepasJSTRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasetsNucleic Acids Res201947D607D13\n3047624362ShannonPMarkielAOzierOBaligaNSWangJTRamageDCytoscape: a software environment for integrated models of biomolecular interaction networksGenome Res2003132498504\n1459765863NikitinAEgorovSDaraseliaNMazoIPathway studio-the analysis and navigation of molecular networksBioinformatics20031921557\n1459472564HamersFPLankhorstAJvan LaarTJVeldhuisWBGispenWHAutomated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuriesJ Neurotrauma200118187201\n1122971165RidgeSAWorwoodMOscierDJacobsAPaduaRAFMS mutations in myelodysplastic, leukemic, and normal subjectsProc Natl Acad Sci U S A199087137780\n240672066LawsonLJPerryVHDriPGordonSHeterogeneity in the distribution and morphology of microglia in the normal adult mouse brainNeuroscience19903915170\n208927567BartanuszVJezovaDAlajajianBDigicayliogluMThe blood-spinal cord barrier: morphology and clinical implicationsAnn Neurol201170194206\n2167458668RenYYoungWManaging inflammation after spinal cord injury through manipulation of macrophage functionNeural plasticity20132013945034\n2428862769SchnellLFearnSKlassenHSchwabMEPerryVHAcute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cordEur J Neurosci199911364858\n1056437270ThawerSGMawhinneyLChadwickKde ChickeraSNWeaverLCBrownATemporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the Lys-Egfp-ki mouse modelJ Neuroimmunol2013261720\n2371134971LongbrakeEELaiWAnkenyDPPopovichPGCharacterization and modeling of monocyte-derived macrophages after spinal cord injuryJ Neurochem2007102108394\n1766375072StirlingDPLiuSKubesPYongVWDepletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcomeJ Neurosci20092975364\n1915830173DavidSKronerARepertoire of microglial and macrophage responses after spinal cord injuryNat Rev Neurosci20111238899\n2167372074SalterMWStevensBMicroglia emerge as central players in brain diseaseNat Med201723101827\n2888600775WitcherKGBrayCEDziabisJEMcKimDBBennerBNRoweRKTraumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammationGlia201866271936\n3037817076BlockMLZeccaLHongJSMicroglia-mediated neurotoxicity: uncovering the molecular mechanismsNat Rev Neurosci200785769\n1718016377SzalayGMartineczBLenartNKornyeiZOrsolitsBJudakLMicroglia protect against brain injury and their selective elimination dysregulates neuronal network activity after strokeNat Commun2016711499\n2713977678BurdaJEBernsteinAMSofroniewMVAstrocyte roles in traumatic brain injury\nExp Neurol2016275 Pt 3: 305-15\n79LiddelowSAGuttenplanKAClarkeLEBennettFCBohlenCJSchirmerLNeurotoxic reactive astrocytes are induced by activated microgliaNature20175414817\n2809941480LiYCaoTRitzelRMHeJFadenAIWuJDementia, Depression, and Associated Brain Inflammatory Mechanisms after Spinal Cord Injury\nCells20209\n81BeckersLOryDGericIDeclercqLKooleMKassiouMIncreased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict NeurodegenerationMol Imaging Biol20182094102\n2869537282LagoNKaufmannFNNegro-DemontelMLAli-RuizDGhisleniGRegoNCD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitnessProc Natl Acad Sci U S A2020117665162\n3215211683Olmos-AlonsoASchettersSTSriSAskewKMancusoRVargas-CaballeroMPharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathologyBrain2016139891907\n2674786284NissenJCThompsonKKWestBLTsirkaSECsf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recoveryExp Neurol20183072436\n2980382785YangXRenHWoodKLiMQiuSShiFDDepletion of microglia augments the dopaminergic neurotoxicity of MPTPFASEB J201832333645\n2940161486WheelerDLSariolAMeyerholzDKPerlmanSMicroglia are required for protection against lethal coronavirus encephalitis in miceThe Journal of clinical investigation201812893143\n2937688887ChanWMMohammedYLeeIPearseDDEffect of gender on recovery after spinal cord injuryTranslational stroke research2013444761\n2432334188DattoJPBastidasJCMillerNLShahAKArheartKLMarcilloAEFemale Rats Demonstrate Improved Locomotor Recovery and Greater Preservation of White and Gray Matter after Traumatic Spinal Cord Injury Compared to MalesJ Neurotrauma201532114657\n2571519289FarooqueMSuoZArnoldPMWulserMJChouCTVancuraRWGender-related differences in recovery of locomotor function after spinal cord injury in miceSpinal cord2006441827\n1613001990SipskiMLJacksonABGomez-MarinOEstoresISteinAEffects of gender on neurologic and functional recovery after spinal cord injuryArchives of physical medicine and rehabilitation200485182636\n1552097891FukutokuTKumagaiGFujitaTSasakiAWadaKLiuXSex-Related Differences in Anxiety and Functional Recovery after Spinal Cord Injury in Mice\nJ Neurotrauma2020\n Pre-depletion of microglia with PLX5622 reduces infiltrating cells and reactive oxygen species (ROS) production after SCI.", '1 qPCR analysis in RNA isolated from the cerebral cortex.', '2 The effect of chronic neuroinflammation on SCI-mediated brain pathology.'] | Figure 1 ( ) PLX5622 diet or vehicle chow were fed to animals three weeks before injury and remained for 2 days after injury. ( ) Body weight was recorded both prior and after injury. All injured mice appeared significant loss of body weight. PLX had no effects on animal weight both prior and after injury. n = 30 mice/group before SCI and 12 (Sham/Veh), 12 (Sham/PLX), 18 (SCI/Veh), and 18 (SCI/PLX) mice after SCI. ( ) Food intake was recorded both prior and after injury. In all injured mice, food consumption decreased significantly. PLX had no effects on food consumption both prior and after injury. n = 15 mice/group (Before injury) and 10 (Sham/Veh), 10 (Sham/PLX), 15 (SCI/Veh), and 15 (SCI/PLX) mice (After SCI). ( ) Representative dot plots show the relative immune cell composition in the impact site of the spinal cord at two days post-injury. ( ) The number of living CD45 CD11b Ly6C microglia, CD45 CD11b infiltrating myeloid cells, CD45 CD11b Ly6C Ly6G monocytes, and CD45 CD11b Ly6C Ly6G neutrophils are quantified. n = 6 (Sham/Veh), 6 (Sham/PLX), 7 (SCI/Veh), and 7 (SCI/PLX). ( ) Representative histograms show the relative production of ROS in microglia, bulk infiltrating myeloid cells, monocytes, and neutrophils as measured by DHR123. ( ) The mean fluorescence intensity (MFI) of dihydrorhodamine 123 (DHR123) was quantified for all cells. For all flow cytometry experiments. n = 6 (Sham/Veh), 6 (Sham/PLX), 7 (SCI/Veh), and 7 (SCI/PLX). ( ) Quantification of the myeloid marker CD11b and the pro-inflammatory cytokine TNF by qPCR analysis at 2 days post-injury. Total RNA was extracted from sham or injured spinal cord. n = 4 (Sham/Veh), 5 (Sham/PLX), 5 (SCI/Veh), and 6 (SCI/PLX). ** 0.01, *** 0.001, **** 0.0001, ++++ 0.0001, vs. Sham/Veh group. # 0.05, ## 0.01, ## 0.001, #### 0.0001, vs. SCI/Veh group. 2-way ANOVA following Tukey's multiple comparisons test. | yes |
PMC6280057 | Figure_1 | oa_package/dd/8b/PMC6280057.tar.gz | ['Radiographic measurements of preoperative, inter-stage, postoperative and last clinical follow up including long-standing 36 films were adequately obtained in 34 patients (85%) ().', 'staged versus same-day surgerySpine (Phila Pa 1976)169309331991194837926SilvaFELenkeLGAdult degenerative scoliosis: evaluation and managementNeurosurg Focus28E1201027TempelZJGandhokeGSBonfieldCMOkonkwoDOKanterASRadiographic and clinical outcomes following combined lateral lumbar interbody fusion and posterior segmental stabilization in patients with adult degenerative scoliosisNeurosurg Focus36E11201428TormentiMJMaseratiMBBonfieldCMOkonkwoDOKanterASComplications and radiographic correction in adult scoliosis following combined transpsoas extreme lateral interbody fusion and posterior pedicle screw instrumentationNeurosurg Focus28E7201029YadlaSMaltenfortMGRatliffJKHarropJSAdult scoliosis surgery outcomes: a systematic reviewNeurosurg Focus28E32010.'] | Fig. 1. In a 60-year-old female, preoperative coronal Cobb angle of 69 and lumbar lordosis of 46 (A) were corrected to 47 and 60 after lateral interbody fusion (B) and 26 and 58 after posterior spinal fusion (C). The angles measured 27 and 54 respectively at 2 years later (D). | yes |
PMC5977432 | Figure_12 | oa_package/79/75/PMC5977432.tar.gz | [] | Fig. 12. Aneurysmal bone cyst in the right superior ethmoid sinus. (a) Contrast-enhanced CT depicts the bony expansion by a fluid-filled cavity and the dehiscent lamina papyracea (arrow) with lateral displacement of the right globe; and (b) the T2W MRI clearly demonstrates the characteristic fluid-fluid levels. | yes |
PMC11558498 | Figure_13 | oa_package/5d/2d/PMC11558498.tar.gz | [] | Figure 13 Longitudinal US planes of fingers. (A) Rupture of A2 and A3 pulleys with >1 mm separation of flexor tendons from the cortical bone during resisted flexion (yellow crosses). (B) Contralateral healthy side. | yes |
PMC9431694 | Figure_8 | oa_package/a5/70/PMC9431694.tar.gz | ['With this type of injury, rA6-tdTomato localized to the site of neuron membrane injury, colocalizing with genomically encoded annexin A6GFP at the repair cap (A).', 'Wheat germ agglutinin (WGA) was used to label the neuron membrane, which showed clear disruption of the neuronal process after transection (B).', 'Four seconds after transection, when the first image was acquired, rA6-tdTomato was detectable at the transected stumps (, B and C, and Supplemental Video 6).', 'rA6-tdTomato fluorescence intensity at the severed stumps continued to increase through the 60 seconds of imaging (C).', 'Recombinant annexin A6 binds neuronal membrane lesions.'] | Figure 8 Recombinant annexin A6 binds neuronal membrane lesions. ( ) Embryonic neurons were isolated from mice, matured, and laser damaged in the presence of rA6-tdTomato. rA6-tdTomato (shown in red) colocalizes with genomically encoded annexin A6GFP (green) at the site of muscle membrane injury (white arrow). Neuron outlined in white dotted line. ( ) After transection of neuronal processes, rA6-tdTomato (red) localizes at the stumps of the severed process (white arrows). WGA-350 (blue) outlines the neuron. ( ) rA6-tdTomato fluorescence signal increases at the process stumps with time (white arrows). Multiple neurons from 3 mice. Scale bar: 5 m. | yes |
PMC11281938 | Figure_2 | oa_package/f5/34/PMC11281938.tar.gz | ['Section shows sub-epidermal collection of inflammatory cells having variably sized granuloma (arrow) with intervening small chronic inflammatory cells (asterisk) (HE stain, 10 ).'] | Figure 2 Section shows sub-epidermal collection of inflammatory cells having variably sized granuloma (arrow) with intervening small chronic inflammatory cells (asterisk) (HE stain, 10). | yes |
PMC8853951 | Figure_1 | oa_package/a6/63/PMC8853951.tar.gz | [')Central IllustrationKey Wordscardiorespiratory distressechocardiographyheart failureinterventional cardiologypercutaneous device closureruptured sinus of Valsalva aneurysmAbbreviations and AcronymsAR, aortic regurgitationBNP, brain-type natriuretic peptideCRP, C-reactive proteinLV, left ventricleLVEF, left ventricular ejection fractionNCC, noncoronary cuspPDA, patent ductus arteriosusRA, right atriumRSOV, ruptured sinus of Valsalva aneurysmRV, right ventricleTEE, transesophageal echocardiographyTTE, transthoracic echocardiographyCase DescriptionWe report the case of a 28-year-old woman who presented to us with an 8-month history of slowly progressive dyspnea and palpitations, preceded by an episode of chest pain, and who was currently in New York Heart Association functional class III, with a history of pedal edema for 2 months.', 'Chest x-ray revealed cardiomegaly with clear lung fields ( 1A), whereas electrocardiography showed sinus rhythm and low voltage complexes with poor R-wave progression ( 1B).', 'Transthoracic echocardiography (TTE) showed dilatation and rupture of the noncoronary sinus of Valsalva into the right atrium (RA) ( 1C and 1D) and dilatation of all 4 cardiac chambers with a left ventricular ejection fraction (LVEF) of 60%.', '5 mm at the noncoronary cusp (NCC) end ( 1E).', ' 1Preprocedural Chest X-Ray, Electrocardiogram, and Echocardiography(A) Chest x-ray bedside anteroposterior (AP) view showing cardiomegaly with clear lung fields.', 'LCC = left coronary cusp; other abbreviations as in 1.', 'LCA = left coronary artery; RCA = right coronary artery; RSOV = ruptured sinus of Valsalva; other abbreviations as in s 1 and 2.', 'Abbreviation as in 1.'] | null | yes |
PMC6385511 | Figure_2 | oa_package/4a/58/PMC6385511.tar.gz | ['08PVBlistering disorder5120DLE Discoid lupus erythematosus; FFA Frontal fibrosing alopecia; PF Pemphigus foliaceus; TC Tinea capitis; LPP Lichen planopilaris; AA Alopecia areata; PV Pemphigus vulgarisAmong total cases with THC, the majority (n = 5) were cases of DLE [].', 'Trichoscopy ( 20) showing (a) Case of discoid lupus erythematosus with a distal tubular hair cast, (b) Case of discoid lupus erythematosus with two casts within a shaft (black arrowheads) and extensive surrounding scales (asterisk)Trichoscopy ( 20) showing a case of pemphigus foliaceus with a single cast surrounding two hair shafts (white arrowhead) and extensive surrounding scalesThe result of different THC patterns of the cases is summarized in Table 2.', 'Two casts within a shaft were present in two cases of DLE [b] and one case of AA [].'] | Figure 2 Trichoscopy (20) showing (a) Case of discoid lupus erythematosus with a distal tubular hair cast, (b) Case of discoid lupus erythematosus with two casts within a shaft (black arrowheads) and extensive surrounding scales (asterisk) | yes |
PMC2682408 | Figure_5 | oa_package/f9/73/PMC2682408.tar.gz | [' 5)Jobe [1] developed the original MCL reconstruction and described the technique with initial results.', '', ')\nModified Jobe techniqueA skin incision centered over the medial epicondyle.'] | Fig.5 The original MCL reconstruction technique as described by Jobe demonstrating detachment of the flexor-pronator mass, transposition of the ulnar nerve, and bone tunnels directed posterior on the humeral epicondyle (Reprinted with permission from Safran M, Ahmad CS, ElAttrache: ulnar collateral ligament of the elbow. Arthroscopy 2005;21:13811395.) | yes |
PMC7734128 | Figure_2 | oa_package/5a/bc/PMC7734128.tar.gz | ['The diagnosis of Rosai-Dorfman disease was therefore yielded ().', 'Histological features of Rosai-Dorfman disease involving sellar region.'] | Figure 2 Histological features of Rosai-Dorfman disease involving sellar region. H-E staining of specimen reveals the large-size histiocyte with the typically foamy eosinophilic cytoplasm, original magnification 40 (black arrow). Positive immunohistochemical staining for S-100, original magnification 100. | yes |
PMC6610970 | Figure_8 | oa_package/3a/53/PMC6610970.tar.gz | [' 8a).', 'Increased MerTK expression in the Smarca5 cKO cerebellum is attenuated in the absence of C3aR.', 'Scale bar = 50 m, and applies to all panelsIn tissue sections, MerTK immunolabeling in the cerebellum was limited to Iba1+ phagocyte cells.', ' 8b).', ' 8b).'] | Fig. 8 Increased MerTK expression in the cKO cerebellum is attenuated in the absence of C3aR. qRT-PCR analysis indicated that MerTK was increased over 2-fold in the cKO cerebellum at P10 ( =5 mice/genotype), but not at P1 ( =3 mice/genotype). This increase was almost completely attenuated with the loss of C3aR in the dKO mice (* <0.05). Transcripts for two other proteins involved in efferocytosis, SR-B1 and MFG-E8 ( =5 mice/genotype), were not increased in any of the mice. MerTK expression was observed almost exclusively on Iba1 macrophages (arrowheads) and microglia (open arrows) in the mutant cerebellums. Most other labeling with the MerTK antibody was non-specific blood vessel (BV) labeling. Scale bar=50m, and applies to all panels | yes |
PMC5601134 | Figure_3 | oa_package/79/48/PMC5601134.tar.gz | ['Immunoblotting of targets involved in mitochondrial function, synaptic plasticity and mTOR signaling in HT22 cellsData from immunoblots of mitochondrial protein subunit expression (A), CREB, p-CREB, MAPK and p-MAPK (C) as well as PKA and PKC motif immunoblotting (E) are depicted from 0 ng/ml, 0.'] | Figure 3 Immunoblotting of targets involved in mitochondrial function, synaptic plasticity and mTOR signaling in HT22 cells Data from immunoblots of mitochondrial protein subunit expression ( ), CREB, p-CREB, MAPK and p-MAPK ( ) as well as PKA and PKC motif immunoblotting ( ) are depicted from 0 ng/ml, 0.1 ng/ml, 1.0 ng/ml and 10.0 ng/ml TNF stimulation over 24 hours in HT22 cells. The columns represent the fold-changes with standard errors of the mean [ ]; = 3; * < 0.05; ** < 0.01; *** < 0.001 (unpaired Student s -test). Normalization was performed against endogenous GAPDH for mitochondrial proteins as well as PKA and PKC motif immunoblotting; CREB, p-CREB, MAPK and p-MAPK were normalized against total lane intensity via Ponceau S staining. Representative visualisation of the immunoblotting data is shown in Panel , and . | yes |
PMC10401014 | Figure_5 | oa_package/63/f9/PMC10401014.tar.gz | [] | Fig. 5. Other cysteine-reactive compounds, afatinb and DMF, inhibit TLR4 signaling. ( and ) iBMDMs were pretreated with afatinib, DMF, or DSF for 0.5 h before stimulation with LPS (1 g/mL) for 4 h. mRNA levels of the indicated inflammatory cytokines were assessed by qRT-PCR, normalized to and relative to unstimulated cells. ( and ) iBMDMs were pretreated or not with afatinib (10 M) ( ) or DMF (20 M) ( ) for 0.5 h before stimulation with LPS (1 g/mL). Whole-cell lysates were harvested at the indicated time points for immunoblot analysis. ( and ) iBMDMs, pretreated with afatinib (10 M) or DMF (20 M) in the presence or absence of NAC for 0.5 h, were stimulated with LPS (1 g/mL). mRNA levels of the indicated inflammatory cytokines were assessed by qRT-PCR, normalized to . Graphs in , , , and show mean SD; data are representative of three independent experiments. Data were analyzed using a two-tailed Students test. *** < 0.001. | yes |
PMC9908554 | Figure_2 | oa_package/de/26/PMC9908554.tar.gz | [' 2 and 4 6 and Supplementary Figs.', '1)Dephosphorylation of the Y531 epitope controls the lateral entrapment of Fyn-mEos2, leading to downstream activation of ERK/S6 signalling.', 'Fyn is organised into nanoclusters in dendritic spines of hippocampal neurons and in HEK-293T cells.', ' 2A, B).', ' 2D, E) and spines (', ' 2F, G).', ' 2C).', ' 2D, E) and spines (', ' 2F, G).', ' 2D G).', ' 2H J), and their corresponding analysis revealed an immobilisation associated with the constitutively open conformation mutants (', ' 2K, L).', ' 2A G), further validating the notion that switching to an open conformation is conducive to Fyn nanoclustering.', ' 2M).', ' 2N).', ' 2O).', ' 2O).', ' 2) and Fyn with an altered SH3 domain (', ' 2).'] | Fig. 2 Dephosphorylation of the Y531 epitope controls the lateral entrapment of Fyn-mEos2, leading to downstream activation of ERK/S6 signalling. Representative intensity and diffusion coefficient maps for Fyn-mEos2, Fyn-Y531F-mEos2 and Fyn-Y531F-K299M-mEos2 within spines of hippocampal neurons. Note that cooler colours within the intensity and the diffusion coefficient maps designate regions of higher localisation intensities and mobility, respectively. The surface of the spines is outlined for visibility. Mobility of Fyn-mEos2, Fyn-Y531F-mEos2 and Fyn-Y531F-K299M-mEos2 in dendrites and , spines, shown as , the MSD (m ) and , area under the curve (AUC) of the corresponding MSD (m s). Diffusion coefficient maps of Fyn-mEos2, Fyn-Y531F-mEos2 and Fyn-Y531F-K299M-mEos2 expressed in HEK-293T cells. Boxed outlines are shown magnified below in (i). Note that hotter colours within diffusion coefficient maps designate regions of lower mobility. Corresponding MSD curve (m ) and AUC of the MSD (m s). Western blot of HEK-293T cells transfected with either mEos2 (empty control), Fyn-mEos2, Fyn-Y531F-mEos2 or Fyn-Y531F-K299M-mEos2. Analysis of ERK1/2 activity and S6 activity measured using the relative intensity of the corresponding western blot bands. Error bars are standard errors of the mean (SEM). MeanSEM values in were obtained from neurons co-transfected with mCardinal and Fyn-mEos2 ( =8), Fyn-Y531F-mEos2 ( =14) or Y531F-K299M-mEos2 ( =9). MeanSEM values in , were obtained from HEK-293T cells transfected with Fyn-mEos2 ( =10), Fyn-Y531F-mEos2 ( =11) or Y531F-K299M-mEos2 ( =13). MeanSEM values in , were obtained from =3. Statistical comparisons were performed using a one-way ANOVA and Dunnett T3 test for multiple comparisons between groups in , and ; or were performed using a one-way ANOVA and Tukeys test for multiple comparisons between groups in and . The specific adjusted values accounting for multiple comparisons are reported for data considered significantly different ( <0.05). | yes |
PMC3693953 | Figure_8 | oa_package/ad/7f/PMC3693953.tar.gz | ['PVD subjects are good smellers.'] | Figure 8 Sniffin' Sticks score in healthy (left) and normal-tension glaucoma patients (right) with and without PVD. (Modified from [ ], with permission). | yes |
PMC1190207 | Figure_2 | oa_package/ca/36/PMC1190207.tar.gz | ['Microglia activation following A infusion.', 'WT and IL1raKO mice were infused with A or vehicle, and brains prepared as in .', 'WT and IL1raKO mice were infused with A or vehicle, and brains prepared as in .'] | Figure 2 Microglia activation following A infusion. WT and IL1raKO mice infused with A or vehicle for 28 days were sacrificed on day 42 (n = 510 mice/group survived for analysis). Brains were bisected and the right side of the brain was processed for immunohistochemistry while the left hippocampus was dissected and used for biochemical analysis. A) Levels of the pro-inflammatory cytokine IL-1 were significantly higher in IL1raKO mice infused with A compared to WT mice infused with A. B) TNF levels also showed a stronger upregulation in A-infused IL1raKO mice compared to A-infused WT mice. C) F4/80 immunostaining for activated microglia also revealed a significant increase in IL1raKO mice infused with A versus WT mice infused with A. Representative photomicrographs of F4/80-positive microglia in the hippocampus of a D) WT mouse infused with A, and E) IL1raKO mouse infused with A. Arrowheads point to microglia cell bodies. Bar in D-E = 50 m (error bars = SEM; * Significantly different, p < 0.01; ***Significantly different, p < 0.001). | yes |
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