PMC_ID stringlengths 8 11 | Image_num stringclasses 399 values | Online_file_path stringlengths 20 50 ⌀ | Image_info_Cleaned stringlengths 2 20.6k | Caption_Clean stringlengths 1 10.6k ⌀ | label stringclasses 2 values |
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PMC11320587 | Figure_3 | oa_package/c8/2d/PMC11320587.tar.gz | ['Excisional biopsies of the abdominal wall and peritoneum\nwere sent for pathological examination, revealing angioinvasive mucormycosis () caused by Rhizopus\nmicrosporus, as evidenced by the growth from abdominal fluid and abdominal\nwall tissue.', '.', 'Supplementary \nfurther demonstrated the relationship of the novel species from case 1 with other known\nspecies of Apophysomyces, using sequences available for D1/D2, ITS, and\nH3 genes.'] | Figure 3. Perforated sigmoid colon with peritonitis and histopathology. Axial( and ) and coronal ( )contrast-enhanced CT of the abdomen and pelvis demonstrates marked distention of thesigmoid colon with stool (red arrows). Extraluminal gas tracks along the peripheryof the sigmoid colon (yellow arrow) and layering intraperitoneal free fluid (greenarrow) are identified. Blue arrows indicate diffuse peritoneal fat stranding.Histopathological examination on H&E stain from the abdominal wall debridement( ) shows soft tissue necrosis with angioinvasive fungal hyphae(orange arrows) in a medium-sized vessel with fibrin deposits. Abbreviations: CT,computed tomography; H&E, hematoxylin and eosin. | yes |
PMC11505737 | Figure_6 | oa_package/b5/5f/PMC11505737.tar.gz | [' 6A).', ' 6A).', ' 6C-D).', ' 6C, E).', ' 6D, F).', '', '01) relative to NTg-MCMDiscussionThe role of muscle in ALS pathology involves complex interactions, including potential contributions to disease progression and the modulation of MN function.'] | Fig.6 MCM-mutSOD1 applied proximally affects both antegrade and retrograde axonal transport. Representative diagram of MN and myotube co-cultures in a microfluidic chamber. MNs were subjected to transduction with AAV1/2-Cox8-RFP (110 particles/l). Seven days later, cultures were exposed to NTg-MCM and MCM-mutSOD1 in the MN (proximal) or myotube (distal) compartment for 24h for mitochondrial recording. Schematic of a kymograph to quantify mitochondria movements. Green lines and arrows indicate anterograde movements (from MN soma to axons), while red lines and arrows indicate retrograde movements (from axons to MN soma). , Representative kymographs of mitochondrial movement in MN axons exposed to the different MCM, as indicated. , Graphs of axonal mitochondrial velocity quantified from generated kymographs when MCM was applied in the proximal ( ) and distal ( ) chambers. Values of the graph represent the means.e.m. of three independent experiments and analyzed by t-Student test (*P<0.1, **P<0.01) relative to NTg-MCM | yes |
PMC5356631 | Figure_1 | oa_package/b0/b4/PMC5356631.tar.gz | ['Clinical symptoms of vitamin E deficient fisha.'] | Figure 1 Clinical symptoms of vitamin E deficient fish . Vitamin E deficient fish (below) with back muscle atrophy showing sekoke disease (); normal fish above. . Muscle cross section in vitamin E deficient fish; muscle becomes thinner and atrophic (); the cross section of muscle in normal fish (). . The red muscle color in vitamin E deficient fish fades, indicating white muscle disease (), normal fish (). . Leprnorthsis () and exophthalmia in the vitamin E deficient fish (). . Tail of the sick fish is upturned (); normal fish below. . X-radial photograph. Rachiocamposis in sick fish (), normal fish below. . Green liver in vitamin E deficient fish (). . Gonads exhibiting atrophy (), normal fish above. | yes |
PMC6350530 | Figure_7 | oa_package/f7/7a/PMC6350530.tar.gz | ['05) ().', '.'] | Fig. 7. Inhibiting apoptosis increased collagen VI. ( ) Collagen VI was increased in the insertion at day 7. ( ) Representative insertion images of collagen VI for 5 d of injection at day 7 and day 14. Arrows showing positive staining. | yes |
PMC6186031 | Figure_1 | oa_package/f5/9e/PMC6186031.tar.gz | [' 1a) focally arranged in intersecting fascicles admixed with islands of epithelioid cells (', '1b).', '1c).', '1d).', '1e), specifically the spindle cells were strongly positive while the epithelioid cells were weakly positive.', 'Histological features of the sarcoma.', 'f Tumor cells show weak nuclear positivity for TFE3S100 positive, SOX10 negative spindle cell malignancy is a broad pathologic differential.'] | Fig. 1 Histological features of the sarcoma. The tumor is composed of ( ) spindle-shaped cells focally and ( ) arranged in intersecting fascicles with epithelioid islands. The spindle cells have variable shaped vesicular nuclei with occasional mitoses, ( ) whereas the epithelioid cells have round to ovoid nuclei and distinct cytoplasmic borders. Tumor cells were positive for S100. Tumor cells show weak nuclear positivity for TFE3 | yes |
PMC6211739 | Figure_1 | oa_package/42/b3/PMC6211739.tar.gz | ['Histology sections from a diseased smolt from a natural outbreak of mouthrot at a BC farm were used as a reference ().', 'g001Histopathology of the jaw of a smolt from a natural outbreak of mouthrot.', 'g009"/>DiscussionThe macroscopic and microscopic findings of experimentally induced mouthrot described in this study match the pathology in field cases (), as well as what is described in the literature [<xref rid="pone.', 'Marty (Ministry of Agriculture, British Columbia, Canada) reviewed the manuscript and he prepared the micrographs for from sections of a fish that was sampled as part of a regulatory auditing program operated by Fisheries and Oceans Canada.'] | 10.1371/journal.pone.0206951.g001 | yes |
PMC6881280 | Figure_4 | oa_package/ac/33/PMC6881280.tar.gz | ['These markers display normally in tau deficient brains and controls, and LNvs extended normal axonal and dendritic projections (A).', 'As illustrated in B, the number of intersections between the concentric rings and the projections were determined.', 'When we analyzed the effect of tau deficiency, we found a significantly reduced number of axonal crosses at ZT2, representing a reduction in the structural morphology of the sLNv (D) that correlated with an increased circadian activity and decreased sleep at this given zeitgeber time (ZT2).', 'Our results show that loss of tau impinges on circadian structural plasticity and temporal dynamics of the sLNv axonal projections ().'] | FIGURE 4 Effect of tau deficiency on daily rhythms of axonal structural remodeling. Immunolabeling with anti-PDF and anti-CWO antibodies in LNv and DN neurons of adult brains from 7 day-old male flies. CWO immunostaining denotes the proper localization and morphology of DN neurons (arrow heads). Scale bar is 20 m. Scheme representing Sholl analysis in PDF-positive (black) LNv projections. Six concentric and evenly spaced (10 m) rings (in red) are drawn. The centers of the rings are localized at the point where the first dorsal ramification starts in each hemisphere. Representative confocal images of LNv neurons immunolabeled with anti-PDF antibody at ZT-2 and ZT-14, early morning and early evening, respectively. Panels show PDF-positive signal in LNv projections. Scale bar is 25 m. Plots representing Sholl analysis quantification at ZT2 and ZT14 for the corresponding genotypes. dTau flies showed a significant reduction in the spreading across the concentric rings specifically at ZT-2, when compared to controls. No changes were found at ZT-14. Data represent mean and SEM analyzed by one-way ANOVA test, with < 0.01 and < 0.0001 or NS if no statistical significance ( = 1214 hemispheres). | yes |
PMC8148086 | Figure_4 | oa_package/ce/ff/PMC8148086.tar.gz | ['The short parasternal axis reveals bulky vegetation on the tricuspid valve.'] | Figure 4 The short parasternal axis reveals bulky vegetation on the tricuspid valve. | yes |
PMC7003947 | Figure_2 | oa_package/aa/c4/PMC7003947.tar.gz | ['Localization of CLRN1 transcripts in adult human retina by ISH.'] | Figure 2 Localization of transcripts in adult human retina by ISH. (A) Detection of mRNA with a human specific probe on a section of paraformaldehydefixed, paraffinembedded human retina. Note the red punctate ISH signals within the INL and extending towards the NFL. (B) Expression of the human RNA polymerase II subunit A ( ) as a positive control. RPE, retinal pigmented epithelium; OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; NFL, nerve fiber layer. Scale bar=50m. | yes |
PMC9317380 | Figure_4 | oa_package/26/1d/PMC9317380.tar.gz | ['Interestingly, the TACE content in the livers of iRhom2-knockout mice remained unchanged after alcohol stimulation compared to the nonalcoholic treatment group (A).', 'Conversely, the contents of these factors in the serum and liver tissue of iRhom2-knockout mice remained unchanged after alcohol induction (B).', 'In wild mice chronically exposed to alcohol, IL-1 , IL-6, TNF- , and IL-18 mRNA expressions increased significantly (C).', 'However, as for the phosphorylation of NF- B in the liver tissue of iRhom2-deficient mice, there was no significant difference between the alcoholic treatment group and the nonalcoholic treatment group (D,E).', 'Finally, we found that long-term alcohol exposure can significantly increase the level and expression of iRhom2 mRNA in wild mouse liver tissues (F).', 'The iRhom2 gene reduces alcohol-induced inflammation: (A) TACE levels measured with IF and qPCR; (B) the presence of IL-1 , IL-6, IL-18, TNF- , TNFR1, and TNFR2 in tissue, calculated with ELISA; (C) IL-6, IL-18, IL-1 , and TNF- in liver tissue, calculated with qPCR; (D) expression of p-NF- B in liver tissue, analyzed with IF; (E) WB analysis of p-NF- B in liver tissue; (F) iRhom2 levels in mouse livers, analyzed with qPCR and ELISA.'] | Figure 4 The iRhom2 gene reduces alcohol-induced inflammation: ( ) TACE levels measured with IF and qPCR; ( ) the presence of IL-1, IL-6, IL-18, TNF-, TNFR1, and TNFR2 in tissue, calculated with ELISA; ( ) IL-6, IL-18, IL-1, and TNF- in liver tissue, calculated with qPCR; ( ) expression of p-NF-B in liver tissue, analyzed with IF; ( ) WB analysis of p-NF-B in liver tissue; ( ) iRhom2 levels in mouse livers, analyzed with qPCR and ELISA. The data are expressed as the mean value SD ( = 6). * < 0.05 and *** < 0.001 vs. the iRhom2+/+/CON group. | yes |
PMC5053626 | Figure_1 | oa_package/fe/0a/PMC5053626.tar.gz | ['Membranous-cytoplasmic Ccnd1 expression at the invasive front is higher in peripheral cells, in large invasive cell clusters or in specific types of invasionA.', '18) (C; see also Supplementary A).', '003; see also Supplementary C).', 'Interestingly, the expression of Ccnd1 in the cytoplasm and membrane of glandular cells was very low (E; see also Supplementary B).'] | Figure 1 Membranous-cytoplasmic Ccnd1 expression at the invasive front is higher in peripheral cells, in large invasive cell clusters or in specific types of invasion Representative images showing Ccnd1 expression in endometrioid carcinomas of the endometrium (100m bar). Different types of invasion are considered (collective, pushing, MELF, glandular, single cells/small cluster of cells, and vascular). Arrows indicate Ccnd1 stain in the membrane. Evaluation of the differences in membranous-cytoplasmic Ccnd1 expression among the different types of invasion in endometrioid endometrial carcinomas , ductal breast carcinoma , prostatic carcinoma according to Gleason grade or invasion beyond the prostate (pT3) and colonic carcinoma Bars represent mean percentages of positivity and segments one standard deviation. Significant differences between selected pairs are shown with their corresponding p-value, as computed with the linear mixed models. For prostate, -value to evaluate the increasing trend is shown. | yes |
PMC3197557 | Figure_1 | oa_package/fe/eb/PMC3197557.tar.gz | ['Ilustration of a facial dissection with major salivary glands identified [1].'] | Figure 1 [ ]. | yes |
PMC4564453 | Figure_5 | oa_package/fd/54/PMC4564453.tar.gz | [' 5).', 'Post-operative T1-weighted MRI after contrast infusion (a axial, b coronal) showing a gross total resection of ATRTCase 2.'] | Fig. 5 Case 1. Post-operative T1-weighted MRI after contrast infusion ( axial, coronal) showing a gross total resection of ATRT | yes |
PMC10450518 | Figure_1 | oa_package/95/3d/PMC10450518.tar.gz | ['Graphical abstractImage 1KeywordsTemporomandibular jointTranscription factorStem cellsHuman fetus1IntroductionThe temporomandibular joint (TMJ) is an interdependent bilateral synovial joint, allowing rotation and translation movements of the jaw around a fixed bone.', '3ResultsHistological analysis confirmed that between 12 and 20 weeks of human fetus gestational age, the TMJ (, , a) comprises the mandibular condyle (MC), mandibular fossa (MF) belonging to the squamous portion of the temporal bone (TB) and articular disc (AD).', '5Expression of Nanog protein (a l).', '', 'Its structure consists of bundles of collagen fibers, fibroblasts, fibrochondrocytes, and undifferentiated cells (, i).', 'The mandibular condyle, in sagittal sections, is a convex structure, we can observe the fibrous layer (FL), consisting of dense connective tissue, proliferative layer (PL), which is composed of undifferentiated cells, chondrocytes layer (CL), hypertrophic chondrocytes layer (HCL) and formation of bone tissue (BT) (b f; 2b-f; 3b-e, g).', 'The mandibular fossa of the temporal bone (MF) presents its lower surface as slightly concave, a dense connective layer (DCL) which is very similar to the fibrous layer of the condyle, a fibrocartilage proliferative layer (PL) with undifferentiated cells, and temporal bone (TB) (, k).', '2NanogMore precisely, in the mandibular condyle in the FL (fibroblasts and fibrochondrocytes) and PL, there was intense cytoplasmic and nuclear staining (b, d, and f).', 'CL (b, d, and f) and HCL presented predominantly nuclear staining (', 'The mandibular condyle ossification area showed intense immunostaining mainly in the cytoplasm of osteoblasts and in the extracellular matrix (c, e, and h).', 'In the articular disc, fibroblasts, fibrochondrocytes, undifferentiated cells, and cells surrounding blood vessels showed mainly cytoplasmic staining (i and j).', 'Analyzing the mandibular fossa (temporal bone), Nanog presented essentially cytoplasmic staining in DCL fibroblasts and in undifferentiated cells of PL (k and l).', 'Osteoblasts surrounding recently formed temporal bone expressed Nanog in the cytoplasm (l) (See Table I).', 'Stat3 activation is critical for pluripotency maintenanceJ Cell Physiol23420191044105130256396List of abreviationsADArticular DiscBSABovine Serum AlbumineBTBone tissueCLCondrocytes LayerDCLDense connective LayerFLFibrous LayerH/EHematoxilin and EosinHCLHypertrofic Condrocytes LayerHRPHorseradish PerixidaseMCMandibular CondyleMFMandibular FossaNCSCeural Crest Stem CellsOct4 Octamer-binding - 4PLProliferative LayerSox-2SRY (sex determining region Y)-box 2Sox-9SRY (sex determining region Y)-box 2Stat-3signal transducers and activators of transcription)TBTemporal BoneTF-Transcriptional FactorsTMDTemporomandibular DisordersTMJTemporomandibular JointAppendix ASupplementary dataThe following are the Supplementary data to this article:'] | Image 1 | yes |
PMC7482978 | Figure_7 | oa_package/29/47/PMC7482978.tar.gz | ['A cord structure was found on the backside of intertragal notch ().', 'A cord structure is pointed by a mosquito clamp.'] | Figure 7 A cord structure is pointed by a mosquito clamp. Great auricular nerve was yanked with a Penrose drain. | yes |
PMC10890976 | Figure_4 | oa_package/51/0c/PMC10890976.tar.gz | [' 4e).', ' 4e) and mean binocular US-ODE was calculated.', ' 4).', 'Ultrasound-based grading of optic disc elevation (ODE).', 'a e show transorbital, B-scan-ultrasonographic imagesUS-ONSD, US-ODE and fundoscopic papilledema after therapyAll 50 patients benefited from therapy; relapse was ruled out clinically, radiologically and/or invasively.'] | Fig. 4 Ultrasound-based grading of optic disc elevation (ODE). Grade 0 (mean US-ODE 0.087mm) in patient without papilledema and normal ONSD, no pathology. Grade I (mean US-ODE 0.23mm), no papilledema, small ONSD value, no pathology. Grade II (US-ODE 0.52mm), no papilledema, but pathology requiring treatment and ONSD enlargement. , Grade III (US-ODE 1.21mm), fundoscopic papilledema, large US-ONSD and diagnosis with need for treatment. US-based ONSD and ODE measurement. Dotted line marks retina. White double-headed arrow marks area of ONSD measurement. Optic disc elevation is measured from retina at the entrance of the optic nerve (ON) to the maximum of elevation (white arrows) within the vitreous body. show transorbital, B-scan-ultrasonographic images | yes |
PMC11239145 | Figure_2 | oa_package/b1/26/PMC11239145.tar.gz | ['Lateral approach of the left hip.'] | Figure 2 Lateral approach of the left hip. Intraoperative image after a direct lateral incision and a modified Hardinges approach of the left hip were performed. | yes |
PMC4184437 | Figure_4 | oa_package/d0/1f/PMC4184437.tar.gz | ['.', '1177_2047981614534231-fig4"/>DiscussionWe have produced an affordable disposable patient-specific puncture and drainage training kidney phantom with the possibility to practice nephrostomy insertion.'] | Fig. 4. US image of the improved kidney phantom. | yes |
PMC5962066 | Figure_5 | oa_package/37/a0/PMC5962066.tar.gz | ['As shown in , the disappearance of crypt structures and muscle layer thickening of the distal colon were observed in the DSS-treated groups on day 21.', 'g005Representative HE-stained sections of mouse distal colon at day 21.'] | 10.1371/journal.pone.0197668.g005 | yes |
PMC7372504 | Figure_3 | oa_package/43/22/PMC7372504.tar.gz | ['Next the SwiveLock anchor is inserted, with close attention given to maintaining proper tension on the biceps as the anchor is reduced ().', 'All visualization continues to be performed through the standard posterior portal with a 30 arthroscope.'] | Fig 3 All visualization continues to be performed through the standard posterior portal with a 30 arthroscope. Both suture ends are passed through an anchor. A cannula is used to assist with suture management. The anchor is reduced and the sutures are tensioned (A). The white arrow illustrates the anchor reducing with the sutures tensioned allowing for an anatomic tenodesis location. Once the anchor has been completely reduced, one limb of the suture is again passed through the biceps tendon just proximal to the tenodesis site self-retrieving suture passer (B), as illustrated by the blue arrow. | yes |
PMC10558894 | Figure_9 | oa_package/67/1d/PMC10558894.tar.gz | [' A 20-year-old male with posterior gleno-labral articular disruption (GLAD).'] | Figure 9 A 20-year-old male with posterior gleno-labral articular disruption (GLAD). Coronal fat-suppressed proton density (A) and (B) images show discontinuity in the glenoid labrum with hyperintensity in the defect (arrows). H = humerus Image credits: Anshul Sood | yes |
PMC8508793 | Figure_2 | oa_package/cf/81/PMC8508793.tar.gz | ['They demonstrated a feed-forward regulatory loop in which FUS induces the expression of miR-141/200a, which in turn affects protein synthesis (D).', '[101] who observed downregulation of miRNA-1825 in CNS and non-CNS organs of sALS and fALS patients (B).', 'Instead, in the FUS mutant MNs differentiated from mouse embryonic stem cells (ESCs), Capauto and colleagues demonstrated the upregulation of miR-409-3p and miR-495-3p and concomitant downregulation of Gria2, a subunit of the AMPA receptor triggering a cascade of MN-damaging excitotoxic events (E and [110]).', 'Recently, the same group demonstrated that the homeostasis of neurofilaments is also guaranteed by miR-9 and miR-105 (C) by regulating genes as NEFL, PRPH, and INA.', 'The authors demonstrated the establishment of an aberrant regulatory network between miR-125b and the STAT3 pathway, culminating in the abnormal release of the cytokine tumor necrosis factor (TNF ) and the overactivation of MG (J).', 'MiR-218 downregulates the expression of the glutamate reuptake transporter excitatory amino acid transporter 2 (EAAT2), important for the proper regulation of excitatory glutamatergic neurotransmission (A).', 'MiR-206 acts by suppressing the levels of the muscular HDAC4 protein, which in turn promotes NMJ reinnervation and regeneration by inducing the expression of the fibroblast growth factor-binding protein-1 (FGFBP1, H).', 'MiR-23a was proposed as a direct regulator of PGC-1 expression (I), whose signaling networks are involved in mitochondrial biogenesis and function [171].', 'Similarly, the antisense RNA C9ORF72-AS, which contains the expanded reverse-repeated hexanucleotide (GGCCCC)n, also localizes into disease-associated nuclear RNA foci (F and [45,203,204]) whose abundance positively correlates with the severity of ALS and FTD symptoms [199,205].', 'However, similarly to other expansion repeat diseases, in neurodegenerations associated with ATXN2 transcripts, mutant RNAs may also interact with RBPs normally required for ribosomal RNA (rRNA) processing and mRNA splicing, sequestering them to aberrant RNA foci (F and [228]).', 'The same behavior was described for metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) that recruits splicing factors to nuclear speckles and affects serine and arginine-rich (SR) protein phosphorylation (G and [231]).', 'Finally, they suggest that circRNA biosynthesis may be affected by pathogenic FUS mutations through a mechanism possibly affecting splicing regulation (D).', 'Schematic representation of noncoding RNA dysregulation examples in ALS.'] | Figure 2 Schematic representation of noncoding RNA dysregulation examples in ALS. Green, red and T arrows indicate upregulation, downregulation and inhibition activities, respectively. ( ) miR-218 released from degenerating MNs promotes astrocytosis in ALS; ( ) miR-1825 dysregulation causes TUBA4A depolymerization and motor axon defects in ALS; ( ) miR-105 and miR-9 dysregulation affects neurofilament aggregation in ALS; ( ) left: wt FUS protein is involved in a feed-forward regulatory loop along with miR-141/200a (the red spark points to the 3UTR gene mutation G48A); right: mutant FUS (P525L) strongly affects circRNA biogenesis; ( ) Mutant FUS and upregulated miR-409-3p and miR-495-3p downregulate GRIA2, causing excitotoxicity; ( ) lncRNAs ATXN2-AS and C9ORF72-AS accumulate in ALS-associated neuronal RNA foci; ( ) lncRNAs MALAT1 and NEAT1_2 are bound by TDP-43 and FUS proteins in nuclear paraspeckles, which are hyper-assembled in ALS; ( ) myomiR-206 is upregulated in ALS muscle contributing to NMJ reinnervation and regeneration; ( ) miR-23a contributes to mitochondrial dysfunction in ALS skeletal muscle; ( ) miR-125b induces over-activation of microglia and neuroinflammation, through the STAT3 pathway. | yes |
PMC4437790 | Figure_1 | oa_package/cc/d8/PMC4437790.tar.gz | ['Proper positioning of the Fogarty balloons and the effectiveness of vascular occlusion were confirmed with fluoroscopy ( 1).', 'The two Fogarty balloons, over the distal tips of the 5 Fr sheaths, inside the uterine arteries.', 'She was transferred from the angiography suite to the obstetric operating room.'] | Figure 1 The two Fogarty balloons, over the distal tips of the 5 Fr sheaths, inside the uterine arteries. Both balloons were inflated for the confirmation of the effectiveness of the stop flow through fluoroscopic image. | yes |
PMC7430587 | Figure_4 | oa_package/09/47/PMC7430587.tar.gz | ['inoculation route [10], all AGMs displayed varying degrees of pulmonary consolidation with hyperemia and hemorrhage, characterized by depressed and patchy dark red to light pink regions (, arrows).', 'Gross lung pathology in AGMs infected with SARS-CoV-2.'] | Figure 4 Gross lung pathology in AGMs infected with SARS-CoV-2. Dorsal view of lungs from AGM-1 (A), AGM-2 (B) and AGM-3(C) euthanized at 5 dpi with SARS-CoV-2 exhibiting mild to moderate locally extensive pulmonary consolidation with hyperemia and hemorrhage. Dorsal view of lungs from AGM-4 (D), AGM-5 (E) and AGM-6 (F) euthanized at 34 dpi with SARS-CoV-2 exhibiting mild to marked locally extensive pulmonary consolidation with hyperemia and hemorrhage. Dorsal view of control lungs with no significant lesions from SARS-CoV-2 negative AGM (G). | yes |
PMC10378145 | Figure_4 | oa_package/c2/a9/PMC10378145.tar.gz | ['Protein expression was confirmed by Western blotting (A,B).', 'Using Flag-tagged proteins, CRMP1 was found in the cell body (Lv and Sv, C,D) and NPAS3 was primarily found in the nucleus (E, with occasional cells showing cytoplasmic localization instead).', 'In contrast, DISC1 and TRIOBP-1 were each consistently seen to aggregate in the cell body (F,G), by which we mean that they were seen to form intense compact accumulations in the body of the cell that give us visibly more signal than any diffuse staining in the cell body.', 'NPAS3 showed no consistent signs of co-aggregation with any of the other proteins (H K and S5).', '3390/cells12141848/s1, S1: Western blots of insoluble protein fractions, purified from human insular cortex samples; S2: Western blots of non-purified insular cortex sample homogenates; S3: Pairwise comparisons of insoluble protein levels in the insular cortex samples; S4: Expression patterns of Flag-tagged proteins expressed with EGFP alone and of EGFP-fused proteins; S5: Versions of experiments in H K using reciprocal plasmid vectors; S6: Versions of experiments in A G using reciprocal plasmid vectors; S7: Quantified data on CRMP1 and DISC1 co-aggregation; S8: Expression patterns of proteins in HEK293 match those in SH-SY5Y; S9: Western blots showing expression of additional TRIOBP-1 constructs used in this study; Table S1: Sources and generation of plasmid vectors used in this study; Table S2: Primers used for cloning in this study.', 'Systematic pairwise testing of co-aggregation in cell culture.'] | Figure 4 Systematic pairwise testing of co-aggregation in cell culture. ( ) Western blots of Flag-tagged proteins used in these experiments, expressed in HEK293 cells. ( ) Equivalent blot of EGFP-fused proteins used in this experiment. Remaining images show constructs expressed in SH-SY5Y neuroblastoma cells: ( ) Flag-tagged CRMP1 Sv, not aggregating. ( ) Flag-tagged CRMP1 Lv, not aggregating. ( ) Flag-tagged NPAS3, not aggregating. ( ) Flag-tagged DISC1, aggregating. ( ) Flag-tagged TRIOBP-1, aggregating. ( ) Flag-tagged NPAS3 and EGFP-fused CRMP1 Sv, neither aggregating. ( ) Flag-tagged NPAS3 and EGFP-fused CRMP1 Lv, neither aggregating. ( ) Flag-tagged NPAS3 and EGFP-fused DISC1, only DISC1 is aggregating. ( ) Flag-tagged NPAS3 and EGFP-fused TRIOBP-1, only TRIOBP-1 is aggregating. All cell photos are typical of 3 or more independent experiments. Scale bars represent 10 m. shows versions of the experiments in ( ) to ( ) using the reciprocal vectors. | yes |
PMC6198061 | Figure_9 | oa_package/c1/4d/PMC6198061.tar.gz | ['The WT cells showed a stable phenotype, with a dynamic cortical F-actin cytoskeleton but no intracellular LifeAct accumulation ( 9A and Supplementary Movie 1).', 'In contrast, KO organoids initially contained many small LifeAct-positive foci some of which increased in size and turned into lumen-containing MVIs ( 9A and B and Supplementary Movies 2 and 3).', 'We also observed another mechanism of formation via internalization of apical membranes ( 9C and Supplementary Movie 4).', '4 Furthermore, we detected a third route for MVI formation: the internalization of basolateral LifeAct-positive membranes ( 9D and Supplementary Movie 5).', 'To distinguish the relative frequencies of these 3 mechanisms, we tracked 75 lumen-containing MVIs ( 9E).', 'The MVI size and lifetime were heterogeneous, and basally formed MVIs were smaller and shorter-lived than MVIs formed in the cytoplasm ( 9F and G).', 'Labeling for 24 hours after 2 days of differentiation resulted in a large proportion of fluorescein-positive MVIs (78% 20%) ( 9H and I).', ' 9Dynamic characterization of MVI formation.', '(A C) Still images from time-lapse microscopy of individual MVIs (as in 9) show (A) cytoplasmic disintegration, and (B) apical or (C) basal fusion.'] | Figure8 . ( ) Confocal images of LifeAct reporter expression and phalloidin staining. LifeAct-mCherry (red signal, ) reporter transgenic WT and KO organoids werefixed and stained by phalloidin-Alexa488 (green, ). Nuclei were stained by DAPI. Organoids were kept in VPA-containing medium (expansion condition) or for 3 days in enterocyte differentiation medium (VPA+ IWP-2) to induce MVIs. Both lumen-containing and noncontaining F-actin structures were co-stained in differentiated KO organoids (yellow signal in merged image, ). Note that treatment with VPA alone reduced the presence of secretory cells (Paneth and goblet cells) in which spontaneous aggregation of the LifeAct reporter otherwise caused background signals (not shown). : 50 m. ( ) High-resolution confocal analysis of LifeAct reporter expression and phalloidin staining. Organoids after 3 days in enterocyte differentiation medium. On the (4 m), scan of signal intensity was performed on apical microvilli (MV) in WT and on MVIs in KO organoids; basal membrane in a WT organoid was used as a control, microvillus-free membrane. | yes |
PMC9435650 | Figure_7 | oa_package/9f/d9/PMC9435650.tar.gz | ['To verify whether hBD-3 improves the TJ barrier in AD through autophagy activation, mouse -defensin-14 (mBD-14), a mouse ortholog of hBD-3, was subcutaneously injected into the lesions of AD mice (Supplemental A).', 'Administration of mBD-14 to the skin lesions of AD mice also markedly decreased the number of CD4+ T cells (Supplemental D) and tended to reduce the mast cell number, although this effect was not significant (Supplemental E).', 'We then established an AD murine model using AhR-inhibited mice; we observed that AD mice given CH-223191 showed no recovery of ear thickness, TEWL, and dermatitis scores, scratching behavior, or total IgE levels after treatment with mBD-14 (AD mice + CH + mBD-14), although these parameters were recovered in mBD-14 treated AD mice in the absence of CH-223191 (AD mice + mBD-14; , A and B, and Supplemental E).', 'Similarly, as shown in C, in the presence of CH-223191, mBD-14 did not increase Cldn1 and Tjp1 (ZO-1) expression.', 'Moreover, the administration of CH-223191 led to the failure of mBD-14 to improve TJ barrier function in AD mice, thus indicating that AhR is required for the mBD-14 mediated improvements in AD mice (D).', 'AhR signaling is required for mBD-14 mediated improvement in AD mice.'] | Figure 7 AhR signaling is required for mBD-14mediated improvement in AD mice. ( ) Representative images of mouse ears (left) and quantification of ear thickness (right). ( ) Representative histological sections of mouse ears stained with H&E (left) and TEWL of mouse ears on day 19 (right). The yellow lines indicate the epidermis; = 8 per group. Scale bars: 20 m. ( ) Real-time PCR analysis of the indicated genes in mouse ear samples; = 8 per group. ( ) Representative immunofluorescence images (left) and quantification of biotin tracer stops indicated by white arrowheads in the mouse skin (right); = 4 per group. Scale bars: 20 m. Mean SD. * < 0.05, ** < 0.01, *** < 0.001, < 0.05, < 0.01, < 0.0001. Statistical significance was determined by 2-way ANOVA with Tukeys multiple-comparison test. All of the data are representative of 3 independent experiments. | yes |
PMC9950353 | Figure_2 | oa_package/67/6b/PMC9950353.tar.gz | [] | FIGURE 2 Before treatment: presence of indurated, erythematous plaques with thick psoriasiform scales | yes |
PMC5534204 | Figure_1 | oa_package/e9/a3/PMC5534204.tar.gz | [' 1a).', ' 1a).', ' 1b).', '2NSNSNSThe one-way ANOVA test followed by the Student Newman Keuls post hoc test\nL lean, MetS metabolic syndrome, MetS-SN metabolic syndrome group treated with spironolactone, SBP and DBP systolic and diastolic blood pressure, NS no significant different\n', 'The two-way aNOVA test followed by the Student Newman Keuls post hoc test\nCoronary artery diseaseCollagen content is an important characteristic of atherosclerotic plaques, as increased collagen deposits are linked to coronary stenosis and increased plaque stability.', ' 1c h; Supp.', ' 1h).', ' 11 shows that the contractions induced by 10, 100, 300, and 1000 M histamine were significantly stronger in both intact (', ' 11a, n = 7) and denuded (', ' 11b, n = 6) rings treated with aldosterone as compared to those treated with DMSO and spironolactone.', '', 'The two-way ANOVA test followed by the Student Newman Keuls post hoc test\nMonocytes adhesion to the endothelium is regulated by aldosterone in a mineralocorticoid receptor-dependent mannerThe adhesion of monocytes to the endothelium of coronary arteries and their subsequent extravasation constitute the earliest steps of atherosclerosis progression.', ' 12a shows that the degree of monocyte enrichment exceeded 75%, about five times higher than the initial monocyte count (16.', ' 12b).', ' 12c).', '', 'The one-way repeated measures ANOVA test followed by the Holm Sidak post hoc test\nTRPC1 is expressed in macrophages differentiated from pig peripheral blood monocytesWe next investigated whether the expression level of TRPC1 is distinct in differentiated macrophages obtained from the Lean, MetS, and MetS-SN groups.', ' 12).'] | Fig.1 Metabolic phenotype and coronary wall collagen content in Lean, MetS, and MetS-SN pigs. , Time course of changes in blood glucose concentration obtained during intravascular glucose tolerance test. MetS or MetS-SN pigs IVGTTs are compared to that in Lean pigs ( =58 pigs at each data point). * <0.05 (MetS vs. Lean); <0.05 (MetS-SN vs. Lean); *** <0.001; <0.001; the two-way ANOVA test followed by the post hoc StudentNewmanKeuls test. Summary for mean total plasma cholesterol concentrations determined in samples from the three experimental groups. * <0.05; KruskalWallis one-way analysis of variance on ranks followed by the Dunns post hoc test; Massons trichrome staining of coronary artery wall sections. Both non-atherosclerotic coronary artery sections ( , ) and atherosclerotic coronary artery sections ( , ) are shown in the MetS and MetS-SN groups. Collagen is stained and smooth muscles are stained . 100m. adventitia, medial layer, intima, lumen, magnification 20. Quantification of collagen percent area in the media layer and the atherosclerotic lesions. * <0.05; ** <0.01; *** <0.001; <0.05; non-significant. The two-way aNOVA test followed by the StudentNewmanKeuls post hoc test | yes |
PMC10861404 | Figure_3 | oa_package/82/45/PMC10861404.tar.gz | [' 3).', 'Bei Kleinkindern unter 6 Jahren, die die Lokalisation einer diaphys ren Verletzung nicht sicher angeben k nnen, ist darauf zu achten, dass die angrenzenden Gelenkeangrenzenden Gelenke vollst ndig miterfasst werden.'] | null | yes |
PMC8698691 | Figure_4 | oa_package/74/4c/PMC8698691.tar.gz | ['5% decrease of [3H]GBR12935 binding in the ipsilateral rostral striatum (A) and 39.', '2% in the caudal striatum, compared to the contralateral side (B).', '7% (C) and by 28% in the caudal striatum (D) in response to ASYN overexpression.', 'Note that the ASYN animal that showed lateral expression of ASYN (Supplemental S1C) had smaller changes in % internal control when compared to the rest of the ASYN injected animals (A D, green squares).', '05) (E) and caudal (p 0.', '0001) striatum (F).', 'Representative autoradiograms of [3H]GBR12935 binding to DAT in the (A) rostral and (B) caudal striatum and of [3H]DTBZ binding to VMAT2 in the (C) rostral and (D) caudal striatum.'] | Figure 4 Representative autoradiograms of [ H]GBR12935 binding to DAT in the ( ) rostral and ( ) caudal striatum and of [ H]DTBZ binding to VMAT2 in the ( ) rostral and ( ) caudal striatum. Graphs in each panel show the ipsilateral value as percentage of the contralateral binding. The green square represents the animal with lateral ASYN expression in the striatum. GFP ( = 8), ASYN ( = 7). The percentage shows the % decrease in ipsilateral binding, compared to contralateral binding. Data are mean SEM, * < 0.05, ** < 0.01 (unpaired t-tests with Welchs correction). Distance from bregma 0.48 mm, 1.80 mm, 0.26 mm, and 0.92 mm, in ( ), respectively. Pearson correlations, with r and value indicated, of DAT and VMAT2 are presented in ( ) the rostral, and ( ) the caudal level of the striatum. | yes |
PMC5750584 | Figure_1 | oa_package/5a/e6/PMC5750584.tar.gz | ['The sections below describe our understanding on contribution of a range of exposure routes summarized in and the factors which can affect disease susceptibility.', '1038/nature1451026061765Cartoon summarizing the potential routes of prion exposure in animals such as sheep, and mechanisms in which prions may be disseminated between animals.'] | Figure 1 Cartoon summarizing the potential routes of prion exposure in animals such as sheep, and mechanisms in which prions may be disseminated between animals. Red arrows, routes of prion exposure; Broken blue arrows, routes of prion shedding or secretion from an infected animal. | yes |
PMC9726365 | Figure_3 | oa_package/43/c6/PMC9726365.tar.gz | ['.'] | Figure 3. Enhanced MRI of the head showing the presence of an enhanced nodule (arrow) adjacent to the falx cerebri in the left parietal lobe (before SRS). MRI = magnetic resonance imaging, SRS = stereotactic radiosurgery. | yes |
PMC11139809 | Figure_6 | oa_package/11/80/PMC11139809.tar.gz | [' 6).', ' 6).', 'Variation in normal postmortem appearances of the brain at PMCT in several different newborns, axial section.', 'The globes are collapsed and lens opacified (d), and there may be some overlapping of sutures, which should not be confused with a skull fracture (f, arrowhead)Skull fractures should be evaluated using 3D reformats, and the presence or absence of accessory sutures and Wormian bones is helpful [21].'] | Fig. 6 Variation in normal postmortem appearances of the brain at PMCT in several different newborns, axial section. Loss of grey-white matter differentiation and cerebral oedema are normal postmortem brain imaging features ( ). Soft tissue scalp swelling is common after vaginal delivery ( , dashed arrows), and can be asymmetric and high density, in which case it may be a cephalhaematoma. High-density blood in the venous sinuses is normal postmortem venous stasis ( , solid arrows). The globes are collapsed and lens opacified ( ), and there may be some overlapping of sutures, which should not be confused with a skull fracture ( , arrowhead) | yes |
PMC4918195 | Figure_1 | oa_package/37/df/PMC4918195.tar.gz | [' 1).', 'T5x mice exhibit robust accumulation of both beta- amyloid and tau pathologies within the hippocampus, cortex, and amygdala.', 'Scale Bar = 300 m in (a-d), 50 m in (e-g), and 100 m in (i-k)Hippocampal tau hyperphosphorylation is greatly increased by concurrent beta-amyloid pathology.'] | Fig. 1 T5x mice exhibit robust accumulation of both beta- amyloid and tau pathologies within the hippocampus, cortex, and amygdala. Tau (Green; Dako total tau) and beta-amyloid (Red; 6E10) were examined by immunofluorescence and confocal microscopy in half brain coronal sections, revealing appropriate labeling of A plaques and/or tau-laden neurofibrillary tangles in the hippocampus and overlying cortex of each genotype; WT ( ), 5xfAD ( ), Thy-Tau22 ( ), T5x ( ). Confocal settings were first established using T5x mice and then identical settings were used for all genotypes. Higher power images of the CA1 region of the hippocampus and amygdala further demonstrate a lack of either pathology in WT controls ( , ), A pathology in 5xfAD mice ( , ), tau pathology in Thy-Tau22 mice ( , ), a combination of amyloid and tau pathology in T5x ( , ). Scale Bar=300m in ( - ), 50m in ( - ), and 100m in ( - ) | yes |
PMC8719289 | Figure_6 | oa_package/ca/ba/PMC8719289.tar.gz | [] | Fig. (6) Admission axial noncontrast head computed tomography after acute trauma with foci of hyperattenuation (arrows) in the white matter of the frontal lobe bilaterally near the gray-white interface are consistent with hemorrhagic lesions typical of diffuse axonal injury. Another axial image from the same computed tomography study shows subarachnoid hemorrhage in the interpeduncular cistern (white arrow) and intraventricular hemorrhage in the atrium of the right lateral ventricle (black arrow). . ( ). | yes |
PMC4233453 | Figure_1 | oa_package/00/33/PMC4233453.tar.gz | ['\nThe position of the radio-opaque image generally corresponded to the anatomic projection of different duodenal segments upon the abdominal wall; one noted the right-edge superposition of the FB image upon the lumbar spine, characteristic of DII FB positioning an image we encountered in 19 (68%) of the 28 cases presenting with DII-placed FBs ().', 'FB (cutlery handle) in the DII In one case of duodeno-hepatic penetration, one hydro-aerial level was present at the superior edge of the FB.'] | Fig. 1 FB (cutlery handle) in the DII | yes |
PMC10703109 | Figure_4 | oa_package/50/17/PMC10703109.tar.gz | [' Chest X-ray (posteroanterior (PA) view)Post-ICD implantation leads and pseudo-dextrocardia are visible in the image.'] | Figure 4 Chest X-ray (posteroanterior (PA) view) Post-ICD implantation leads and pseudo-dextrocardia are visible in the image. ICD:Implantable cardioverter-defibrillators. | yes |
PMC11139809 | Figure_4 | oa_package/11/80/PMC11139809.tar.gz | [' 4).', 'Axial PMCT images through the abdomen (a, b) and coronal images of the thorax and abdomen (c) demonstrating widespread disseminated gas, far more than in ', 'Note the small, normal postmortem pleural effusions (a, arrows)Body decomposition can affect CT imaging in multiple ways, usually either gas changes to the subcutaneous tissues, bloating or insect infestation, which can give rise to unusual appearances ('] | Fig. 4 Axial PMCT images through the abdomen ( , ) and coronal images of the thorax and abdomen ( ) demonstrating widespread disseminated gas, far more than in Fig. . The extensive nondependent gas is seen within the portal vein and branches, several mesenteric vessels and renal veins. This suggests gastrointestinal infection, likely anaerobic organisms. Note the small, normal postmortem pleural effusions ( , arrows) | yes |
PMC10608316 | Figure_12 | oa_package/15/bc/PMC10608316.tar.gz | [] | Figure 12 Uterine rupture in a thirty-three-year-old patient presented at the emergency department with acute pelvic pain and abnormal uterine contractions during the 37th week of pregnancy. The patient had a prior history of two previous uterine curettages. MRI T2-weighted sagittal ( ) and coronal ( ) images show a complete division of the uterine fundus wall with extrusion of the gestational sac (yellow arrows). | yes |
PMC3058055 | Figure_3 | oa_package/ff/66/PMC3058055.tar.gz | ['To investigate whether carnosine supplementation can decrease the brain A load, immunohistochemistry was performed with the anti-A DE2B4 primary antibody and analysis of this assay showed a significant decrease of intraneuronal A in the hippocampus of treated 3xTg-AD mice (A-D).', 'g003Carnosine supplementation reduces intraneuronal A but not tau accumulation in the hippocampus of 3xTg-AD mice.', 'Diffuse phospho-tau immunoreactivity was found in the CA1 subfield of untreated 3xTg-AD mice (E,G).', 'Interestingly, although carnosine was able to reduce the amyloid load, the treatment produced no decreases of phospho-tau immunoreactivity in the 3xTg-AD CA1 subfield (E-H), indicating that the peptide has no effect on tau pathology.'] | 10.1371/journal.pone.0017971.g003 | yes |
PMC4641720 | Figure_4 | oa_package/50/3e/PMC4641720.tar.gz | [' \n Postoperative T2 axial images.'] | Figure 4 Postoperative T2 axial images. T2-weighted axial images of the thoracic spine MRI shows postoperative changes with en bloc resection of the epidural tumor with decompression of the spinal cord. | yes |
PMC5995925 | Figure_6 | oa_package/d8/fe/PMC5995925.tar.gz | [' 6A and B).', ' 6C and D).', 'Immunofluorescence analysis for the expression of (A) TREM-1 and (C) PGC-1 showing increased expression in RCTI group on comparison with control.', '(A) Immunofluorescence analysis for the expression of COL1 (green) and COL3 (red) showing increased expression in RCTI group on comparison with control.', ' 6C and D).'] | Figure 6 Immunofluorescence analysis for the expression of ( ) TREM-1 and ( ) PGC-1 showing increased expression in RCTI group on comparison with control. Images in the top row are histological sections of control group, and images in the bottom rows are histological sections of RCTI tendons harvested at 35 days (Group-1), 1012 days (Group-2) and 2224 days (Group-3). Images in the left column show nuclear staining with DAPI; the images in the middle column show expression of TREM-1/PGC-1 while the images in the right column show overlay of TREM-1/PGC-1 staining with DAPI. Images were acquired at 20x magnification using CCD camera attached to the Olympus microscope. The image shows quantification of the expression TREM-1 ( ) and PGC-1 ( ). The intensity of gene expression as observed through immunofluorescence was acquired and the mean fluorescence intensity (MFI) was quantified from each contralateral control and RCTI specimen. The graphs represent MFI mean values with standard error. ( < < < ). | yes |
PMC3678466 | Figure_2 | oa_package/d9/2e/PMC3678466.tar.gz | ['Immunohistochemistry studies revealed loss of INI-1 staining in neoplastic cells confirming the diagnosis of ATRT ().', '001"/>Histologic features of Atypical Teratoid Rhabdoid Tumor.'] | Figure 2 Histologic features of Atypical Teratoid Rhabdoid Tumor. (a) Histologic examination of the tumor reveals diffuse eosinophilic cytoplasmic globules, vesicular chromatin, and scattered large pleomorphic nucleoli (hematoxylin and eosin 40x). (b) Loss of INI-1 expression of the neoplastic cells by immunohistochemistry staining confirms the diagnosis of ATRT (40x). | yes |
PMC8453197 | Figure_5 | oa_package/25/6d/PMC8453197.tar.gz | ['Excised thyroglossal duct cyst specimen from a 14-year old female patient (case 5).'] | Figure 5 Excised thyroglossal duct cyst specimen from a 14-year old female patient (case 5). Paired iodinated micro-CT imaging at 22.2 micron resolution and histopathological section with H&E staining demonstrate the thyroglossal duct (dashed arrows) anterior to the hyoid bone (B) with areas of cystic change (remnants) from a previously infected and ruptured cyst (*). | yes |
PMC9628656 | Figure_1 | oa_package/44/61/PMC9628656.tar.gz | ['The images below are snapshots taken from the patient s CT scan which show contrast extravasation into the right psoas muscle (figure 1).', 'CT scan of the abdomen and pelvis showing contrast extravasation into the right psoas muscle on axial and coronal views (indicated by black arrow).'] | Figure 1 CT scan of the abdomen and pelvis showing contrast extravasation into the right psoas muscle on axial and coronal views (indicated by black arrow). | yes |
PMC5711047 | Figure_2 | oa_package/17/6e/PMC5711047.tar.gz | ['Validation of the neonatal chest simulation phantomThe average intensities and standard deviations in regions of interest (ROIs) in the healthy and sick lung, bony, and muscle regions of the phantom were compared to those obtained from an X ray of a real neonate, as shown schematically in .', '\n(5)\n\nReal neonatal chest x ray (a) and X ray of neonatal chest simulation phantom (b) used for phantom validation showing schematically the placement of evaluation ROIs.', ' shows these images which were obtained using the same exposure parameters.'] | Figure 2 Real neonatal chest xray (a) and Xray of neonatal chest simulation phantom (b) used for phantom validation showing schematically the placement of evaluation ROIs. | yes |
PMC2242831 | Figure_4 | oa_package/fc/b1/PMC2242831.tar.gz | ['We found that Meth (50 and 250 M) inhibited E(IgG) phagocytosis (A and 4B) by 20 and 45 , respectively.', 'Similar effects were observed with Clq (A and 4B) These results demonstrate that Meth inhibits Fc -mediated phagocytosis in macrophages and are consistent with the observations that the macrophage Fc receptors are continuously recycled between phagosomes and the plasma membrane [42], a process that requires appropriate acidification of secretory vesicles and tubules for trafficking [43].', 'Meth and Clq Inhibit Phagocytosis in Mouse Peritoneal Macrophages(A) Cells were incubated in indicated concentrations of Meth or Clq for 2 h, and then IgG coated erythrocytes were added.', 'Clq and Meth (10 and 50 M) inhibited phagocytosis of Ca and Cn by macrophages by 40 (C).', 'Moreover, Meth enhanced the proliferation of fungi within macrophages (D), indicating that intracellular replication of both yeast was facilitated by Meth.'] | Figure 4 Meth and Clq Inhibit Phagocytosis in Mouse Peritoneal Macrophages (A) Cells were incubated in indicated concentrations of Meth or Clq for 2 h, and then IgG coated erythrocytes were added. Extracellular uningested EIgG were lysed and removed. Phagocytic index (PI) was quantified and inhibition is indicated as percent of control. Data were collected from four to seven experiments ( = 300 cells, mean SEM, *** < 0.0001, two-tailed ANOVA). (B) Images of macrophage cells impaired in the phagocytosis of opsinized sheep erythrocytes after 2 h of Meth or Clq treatment. Arrows denote phagocytosed erythrocytes. Scale bar, 10 m. (C, D) J774.16 cells were exposed to PBS, chloroquine, or methamphetamine for 2 h followed by incubation with Cn or Ca. The phagocytic indices (ratio of intracellular yeast to the number of macrophages counted) were determined after 1 h or 30 min for Cn and Ca, respectively (C). (Statistics = 300, mean SEM, * < 0.05, two-tailed ANOVA.) CFU determinations were preformed after 24 h incubations (D). The values are the mean and standard deviation from determinations made in triplicate wells ( = 300 cells, mean SEM, * < 0.05, two-tailed ANOVA.). Experiments were repeated three times with similar results. | yes |
PMC6018842 | Figure_3 | oa_package/db/60/PMC6018842.tar.gz | ['Selective suture ligation and clip placement was then used to control the leak (figure 3).', 'Ligated thoracic duct.'] | Figure 3 Ligated thoracic duct. | yes |
PMC7515861 | Figure_3 | oa_package/a1/21/PMC7515861.tar.gz | [' 3a,b).', ' 3c,d) indicating less severe muscle phenotypes when KO was induced at an older age.', ' 3a d).', 'Initiating EphA4 KO at a later age has less detrimental effects on muscle function, but does not provide benefit in SOD1G93A mice.', 'EphA4 protein expression in rodent skeletal muscle can persist in young adult animals before declining in older animals12.', ' 3e,f).', ' 3).'] | Figure 3 Initiating EphA4 KO at a later age has less detrimental effects on muscle function, but does not provide benefit in SOD1 mice. Grip strength and CMAP amplitude are reduced to a lesser extent in SOD1 mice when Tamoxifen-induced EphA4 KO is initiated at 7weeks of age. RMANOVAs all revealed significant effects of genotype, time and genotype/time interactions. Significant effects on fore-paw grip strength were observed for SOD1 genotype (F(1, 57)=26.65; p<0.0001) but not EphA4 genotype, however Tukeys T-test show a significant effect of EphA4 genotype at the 10week time point (p=0.009). Hind-paw strength was effected by both SOD1 (F(1, 58)=70.02; p<0.0001) and EphA4 genotypes (F(1,58)=8.70; p=0.0046). TA muscle CMAP amplitude was significantly affected by SOD1 (F(1, 58)=70.02; p<0.0001) but not EphA4 genotype. RMANOVA on CMAP amplitude in GA muscle revealed effects of both SOD1 (F(1, 58)=225.32; p<0.0001) and EphA4 genotype (F(1, 58)=5.14; p=0.0272). (n=1214 in WT groups, 18 in SOD1 groups, fig. ). Detrimental effects of EphA4 are fully attenuated when KO is induced at 1721weeks of age in WT mice, but SOD1 mice are end stage at this age range, precluding test of EphA4 KO effects in SOD1 mice. Unpaired t-test reveals no difference in fore-paw grip strength between EphA4WT and EphA4cKO mice at 22weeks of age Unpaired t-test reveals no difference in hind-paw grip strength between EphA4WT and EphA4cKO mice at 22weeks of age. (n=8 EphA4WT and 10 EphA4cKO, all females, fig ). | yes |
PMC4612755 | Figure_3 | oa_package/e4/f0/PMC4612755.tar.gz | ['2-cm mucosal-based lesion lying posteriorly within the gastric antrum ().', '4Abdominal CT showing 1.'] | Figure 3 Abdominal CT showing 1.2-cm mucosal-based lesion lying posteriorly in the gastric antrum. | yes |
PMC9327652 | Figure_1 | oa_package/33/cb/PMC9327652.tar.gz | [] | FIGURE 1 Nonnecrotizing granulomatous tubulointerstitial nephritis with small numbers of eosinophils involving cortex and medulla | yes |
PMC11536967 | Figure_3 | oa_package/cd/c7/PMC11536967.tar.gz | [' 3).', '\nHistopathology of excised conjunctiva on amniotic membrane reveals growth of squamous epithelium (arrow) lacking goblet cells on the amniotic membrane (arrowhead) (hematoxylin-eosin stain, original magnification x200)\n\n'] | Fig. 3 Histopathology of excised conjunctiva on amniotic membrane reveals growth of squamous epithelium (arrow) lacking goblet cells on the amniotic membrane (arrowhead) (hematoxylin-eosin stain, original magnification x200) | yes |
PMC2627904 | Figure_4 | oa_package/3d/cd/PMC2627904.tar.gz | ['CMECME was significantly more common in the CM group than the non-CM group (Table 1)().', 'g004Photomicrograph of cystoid macular edema in the outer plexiform layer (arrows).'] | 10.1371/journal.pone.0004317.g004 | yes |
PMC5864235 | Figure_4 | oa_package/9b/16/PMC5864235.tar.gz | [' 4) following drug addition.', 'Representative images and time-series data from NAD(P)H autofluorescence measurements in wild-type mouse cortical neurons exposed to mitochondrial inhibitors\na Brightfield and NAD(P)H autofluorescence images were captured on a Zeiss Axiovert 100 microscope.', '5 M) increased respiratory NADH oxidation, decreasing autofluorescence\n\nTesting respiratory complex activity\nSuggested drug concentrations are listed in Table 2.', ' 4).', ' 4).', ' 4).', ' 4).'] | Fig. 4 Representative images and time-series data from NAD(P)H autofluorescence measurements in wild-type mouse cortical neurons exposed to mitochondrial inhibitors Brightfield and NAD(P)H autofluorescence images were captured on a Zeiss Axiovert 100 microscope. Time-series autofluorescence measurements from the region of interest marked within a white polygon in (A)(iii). The precise time-points of the images in (A) are marked (i)-(iv) on the graph. Baseline fluorescence was recorded for 5min pre-treatment and used to normalise the signal. Inhibition of the F F ATP synthase with oligomycin (2g/ml) reduced NADH consumption by the respiratory chain, leading to an increase in the autofluorescence signal. Subsequent mitochondrial uncoupling with FCCP (0.5M) increased respiratory NADH oxidation, decreasing autofluorescence | yes |
PMC4976940 | Figure_6 | oa_package/a0/71/PMC4976940.tar.gz | ['Cell yields were very low (), and the few survivors showed smaller Ca2+ transient, weaker contraction and lack of responsiveness to beta-adrenergic stimulation.', 'g006Comparing the cells isolated using traditional method and the in-vivo cannulation method.'] | 10.1371/journal.pone.0160605.g006 | yes |
PMC6064759 | Figure_2 | oa_package/61/72/PMC6064759.tar.gz | ['There was no evident vertebral artery injury ().', 'CT angiogram of the cervical spine showing transluminal migration of the foreign body through the esophagus, and its close relation to the left vertebral artery.'] | Fig 2 CT angiogram of the cervical spine showing transluminal migration of the foreign body through the esophagus, and its close relation to the left vertebral artery. The foreign body is depicted with a yellow arrow | yes |
PMC7750145 | Figure_1 | oa_package/e6/4d/PMC7750145.tar.gz | ['Red circle showing a mottled, lacey, net-like rash resembling livedo reticularis in the region of pain.', ' '] | Fig. 1 Red circle showing a mottled, lacey, net-like rash resembling livedo reticularis in the region of pain. | yes |
PMC11469643 | Figure_1 | oa_package/16/2a/PMC11469643.tar.gz | ['In the initial assessment of painless oculomotor palsy, brain MRI revealed a small, rounded lesion adjacent to the left posterior clinoid process ().', 'Pre-surgical MRI (A C) showing the presence of a lesion with low signal intensity on T2-weighted sequences (A, B) of 0.'] | Figure 1 Pre-surgical MRI (AC) showing the presence of a lesion with low signal intensity on T2-weighted sequences (A, B) of 0.70.6cm adjacent to anterior clinoid process and tents, concerning the oculomotor left cistern, with peripheral enhancement in post-contrast sequences (C) contacting the left third cranial nerve. No evidence of aneurysms in angiogram MRI (D). Head CT scan (E) with a calcified exophytic lesion concerning the left anterior clinoid. | yes |
PMC11175764 | Figure_1 | oa_package/96/dd/PMC11175764.tar.gz | ['-A<graphic xlink:href="jbjsrev-12-e24.', '00019-g001" position="float"/>-B<graphic xlink:href="jbjsrev-12-e24.', '00019-g002" position="float"/>-C<graphic xlink:href="jbjsrev-12-e24.'] | Fig. 1-A | yes |
PMC10213653 | Figure_2 | oa_package/2b/6b/PMC10213653.tar.gz | [] | Figure2 Representative thyroid nodule images were acquired with the computer-aided diagnosis (CAD) system. | yes |
PMC7452724 | Figure_1 | oa_package/48/59/PMC7452724.tar.gz | ['Radiographic examination of #21 showed periapical rarefaction along with a 3 mm open apex which was confirmed using Image J software (National Institute of Mental Health, Bethesda, MD, USA) (A).', '001A.', 'After access opening and working length determination (B), minimal filing with size #15Hfile (Mani Inc, Utsunomiya, Japan) was done followed by copious irrigation with 20 mL of 0.', 'The tooth was isolated, anesthetized, re-accessed, and calcium hydroxide was removed through the same irrigation protocol as in the previous appointment (C).', 'A volume of 10 mL of blood was drawn from the patient s cubital vein (D), collected in a glass test tube, and centrifuged at 400 g (times gravity) for 10 min in a tabletop centrifuge machine (E and F) (Model R-8C Plus, Remi Laboratories, Mumbai, India).', 'Choukroun s PRF was obtained in the test tube (G) as the middle layer with acellular plasma at the top and red blood cell at the bottom using sterile tweezers, the fibrin clot was removed (H).'] | 10.18053/jctres.06.202001.001 | yes |
PMC2807439 | Figure_6 | oa_package/3e/8f/PMC2807439.tar.gz | ['Growth of well differentiated liposarcoma (x 100) hematoxylin and eosin staining Non-differentiated part of the tumor with the pattern of malignant fibrous histiocytoma (x 100) hematoxylin and eosin stainingPart of osteosarcoma (X 200) hematoxylin and eosin staining Part od chondrosarcoma (x 100) hematoxylin and eosin stainingThe perioperative period was uneventful and the patient was discharged home 3 days later.'] | Figure 6 Growth of well differentiated liposarcoma (x 100) hematoxylin and eosin staining | yes |
PMC10043603 | Figure_3 | oa_package/69/a0/PMC10043603.tar.gz | ['Additional bilateral breast and axillary ultrasound was performed (), confirming the presence of numerous enlarged lymph nodes, the largest one measuring 30 5 mm, with Doppler signal showing intra- and extranodal vascularization, playing in favour of an active inflammatory process ().', '.'] | Figure 3. Ultrasound scans of right ( ) and left ( ) armpits showing lymph nodes with short to long axes ratio <0.5 (white rectangles). Oval shape, bilateralism, and visible fatty hilum are suggestive for a benign, reactive aetiology. | yes |
PMC4557123 | Figure_2 | oa_package/27/25/PMC4557123.tar.gz | ['We found that transient depletion of Tregs resulted in elevated mRNA expression levels of leukocyte trafficking molecules by the CP of AD-Tg/DTR mice, relative to DTx-treated AD-Tg/DTR littermates (a), and immunohistochemistry confirmed elevated ICAM-1 immunoreactivity (', 'We observed immune cell accumulation in the brain, including elevated numbers of CD45high/CD11bhigh myeloid cells, representing infiltrating mo-M 18 and CD4 T cells (d; Supplementary ', 'In addition, brief and transient depletion of Tregs resulted in a marked enrichment of Foxp3 Tregs among the CD4 T cells that accumulated within the brain, as assessed by flow cytometry (e,f).', 'RT-qPCR analysis of the hippocampus showed increased expression of foxp3 and il10 mRNA levels (g), and immunohistochemical analysis revealed T cells adjacent to A plaques (', '2h); among these were IL-10- and Foxp3-expressing cells (i).', 'Examining the hippocampal cytokine milieu by RT-qPCR, revealed reduced mRNA expression levels of the pro-inflammatory cytokines, il-12p40 and tnf- (j), and immunohistochemical analysis showed a reduction in gliosis (', 'Moreover, cerebral A plaque burden in the hippocampal dentate gyrus (DG) and the cerebral cortex (fifth layer), two brain regions exhibiting robust A plaque pathology in 5XFAD AD-Tg mice24, was reduced (m,n).', 'Next, we evaluated the effect on spatial learning and memory performance using the Morris water maze test, and found a significant improvement in cognitive function in AD-Tg/DTR mice following Treg depletion, relative to DTx-treated AD-Tg/DTR age-matched controls, reaching performance similar to that of WT mice (o q).', "We therefore treated 5XFAD AD-Tg mice with a weekly administration regimen of GA over a period of 4 weeks (henceforth, weekly GA'; schematically depicted in Supplementary a).", 'We found that 5XFAD AD-Tg mice treated with weekly GA showed reduced neuroinflammation (Supplementary b,c), enhanced hippocampal expression of brain-derived neurotrophic factor (bdnf) and insulin-like growth factor-1 (igf1) (Supplementary ', '2d) and improved cognitive performance (Supplementary e g), which lasted up to 2 months after the treatment (Supplementary ', 'These results indicated that while a single session of targeting Tregs is effective, repeated sessions of treatment would be advantageous for maintaining a long-lasting therapeutic effect, similar to our observations following weekly GA treatment (Supplementary h,i).', 'Mice were either injected according to a weekly GA regimen33 (Supplementary a) or daily-GA administration (', 'org/1999/xlink" xlink:href="ncomms8967-f1"/>Transient conditional depletion of Foxp3 Tregs activates the CP for leukocyte trafficking and mitigates AD pathology.'] | Figure 2 Transient conditional depletion of Foxp3 Tregs activates the CP for leukocyte trafficking and mitigates AD pathology. ( ) AD-Tg/Foxp3-DTR and non-DTR-expressing AD-Tg littermates (AD-Tg/Foxp3-DTR ; AD-Tg control) were treated with DTx for 4 consecutive days. mRNA levels of , and in the CP of 6-month-old AD-Tg/Foxp3-DTR mice, 1 day after last injection ( =68 per group; Student's -test). ( ) Representative images of the CP, immunostained for E-Cadherin (green), ICAM-1 (red) and Hoechst, in 6-month-old AD-Tg/Foxp3-DTR mice, 1 day after last DTx injection (Scale bar, 25m). ( ) mRNA levels of and , in cultured CP cells, 24h after addition of differentiated Tregs, IFN- or their combination, relative to untreated (UT) cells ( =34 per group; one-way ANOVA followed by NewmanKeuls test; NS, not significant). ( ) Flow cytometry analysis of the brain of 6-month-old AD-Tg/Foxp3-DTR mice, 3 weeks following last DTx injection, showing increased numbers of CD11b /CD45 mo-M and CD4 T cells ( ), and increased CD4 Foxp3 ( , ) Treg frequencies ( =47 per group; Student's -test). ( ) mRNA levels of and in the brain of 6-month-old AD-Tg/Foxp3-DTR mice, 3 weeks after last DTx injection ( =68 per group; Student's -test). ( , ) Representative images of A (green) and CD3 (red) ( ), or Foxp3 and IL-10 (in red) immunostaining ( ) in 6-month-old AD-Tg/Foxp3-DTR , 3 weeks following last DTx injection (scale bar, 10m). ( ) mRNA levels of and in the brain of 6-month-old AD-Tg/Foxp3-DTR mice, 3 weeks after last DTx injection ( =68 per group; Student's -test). ( , ) Representative images ( ) and analysis ( ) of GFAP immunostaining in hippocampal sections of 6-month-old AD-Tg/Foxp3-DTR mice, 3 weeks following the last DTx injection (scale bar, 250m; =35 per group; Student's -test). ( , ) Representative images ( ) and analysis ( ), of 5-month-old AD-Tg/Foxp3-DTR mice brains, immunostained for A (in red) and Hoechst, 3 weeks after the last DTx injection (scale bar, 250m). Mean A area and plaque numbers in the dentate gyrus (DG) and the cortex fifth layer ( =56 per group; Student's -test). ( ) Morris water maze (MWM) of 6-month-old AD-Tg/Foxp3-DTR , 3 weeks after last DTx injection. DTx-treated mice showed improved spatial learning/memory in the acquisition ( ), probe ( ) and reversal ( ) phases, relative to AD-Tg controls ( =79 per group; two-way repeated measures ANOVA followed by Bonferroni test; * <0.05 for overall acquisition, probe and reversal). In all panels, error bars represent means.e.m.; * <0.05; ** <0.01; *** <0.001. | yes |
PMC3717027 | Figure_4 | oa_package/30/76/PMC3717027.tar.gz | ['Co-localisation and co-immunoprecipitation of nuclear Pcolce with expPABPN1 in myotube cultures.'] | Figure 4 . Pcolce sub-cellular localisation in myotube cultures. (i) Parental IM2, and those stably expressing Ala17- or Ala10- FLAG-tagged PABPN1were co-stained for Pcolce and PABPN1. PABPN1 was detected with 3F5-VHH llama antibody and anti-mouse Alexa 594. Rabbit-anti-Pcolce antibody was detected with Alexa 488. Nuclei are counterstained with DAPI. Scale bars equal 20m. Arrows indicate unfused myoblast cells. (ii) Single confocal microscope section of myonuclei in Ala17 or Ala10 cell clones. Co-localisation of the two proteins is shown in the merged image. Plots of fluorescence intensity distribution (measured across the line in the merged image) show co-localisation of Pcolce and PABPN1 in fluorescent foci (arrows). Representative myonuclei with PABPN1 foci are shown. Scale bars equal 5m. . Immunoprecipitation of PABPN1 in protein extracts from parental IM2, Ala17- and Ala10- PABPN1-FLAG myotube cultures was performed with rabbit-anti-FLAG antibodies. Immunoblotting was conducted with mouse-anti FLAG antibody or rabbit anti-Pcolce. IgG HC is used as a loading control. | yes |
PMC11283996 | Figure_7 | oa_package/94/e5/PMC11283996.tar.gz | ['F7">.'] | Fig. 4. . (A,B) Native images, end-diastole (A) and end-systole (B). The endocardium of the lateral wall is not visible, and the apex cannot be seen. (C,D) Contrast-enhanced images, in the same moments in the cardiac cycle. The LV contour is clearly delineated, during systole there is complete cavity obliteration, with an apical aneurysm (arrow). Source: personal collection. | yes |
PMC9597981 | Figure_5 | oa_package/df/2b/PMC9597981.tar.gz | [' 5A).', ' 5B) [95].', 'A colonic resection specimen from a patient with COVID-19 and no gastrointestinal symptoms shows subtle features of viral infection.', 'Dilated crypts (asterisk) contain mucin-depleted cells with eosinophilic cytoplasm and disorganized nuclei (F)It is worth noting that direct viral infection of the gastrointestinal tract is likely a transient event that causes few, or no symptoms.', ' 5C, D).', ' 5E, F).'] | Fig. 5 A colonic resection specimen from a patient with COVID-19 and no gastrointestinal symptoms shows subtle features of viral infection. The colonic crypts are slightly dilated near the surface and have a slightly tufted appearance (asterisk) that reflects clustered epithelial cells with nuclear crowding ( ). The same areas show strong signal for spike protein RNA by in situ hybridization (asterisk) using a brown chromagen ( ). Another patient with mild respiratory symptoms due to COVID-19 developed gastrointestinal bleeding. Biopsy samples from the duodenal mucosa shows normal villous architecture with patchy hemorrhages (asterisk) and regenerative epithelium with cytoplasmic depletion. Platelet-rich thrombi (asterisk) are present in vessels ( ). A third patient with COVID-19 developed severe diarrheal symptoms presumably due to the pro-inflammatory state promoted by the virus. Samples obtained from the jejunum display mild villous shortening with striking crypt hyperplasia and regenerative epithelial changes unaccompanied by substantially increased inflammation ( ). Colonic samples from the same patient show a similar degree of epithelial cell injury without increased inflammation. Dilated crypts (asterisk) contain mucin-depleted cells with eosinophilic cytoplasm and disorganized nuclei ( ) | yes |
PMC9568698 | Figure_1 | oa_package/05/09/PMC9568698.tar.gz | ['The biopsies were negatives ().', 'Esophagogastroduodenoscopy showed a bulging ampulla of Vater that bled on touch.', ''] | Fig. 1 Esophagogastroduodenoscopy showed a bulging ampulla of Vater that bled on touch. | yes |
PMC11087336 | Figure_2 | oa_package/f5/dd/PMC11087336.tar.gz | [' 2)', 'The probe has a thermiresistance, the temperature should be kept below 75 degreesPatient is supine, the surgeon faces the patient on the side of the pain, the anaesthesiologist headside.'] | Fig.2 OR Setup for Rf-TR. The patient is supine with the head on a horseshoe head rest to clear the shoulders to place the plate of the C-Arm close to the face on the contralateral side to the pain. Also on this side is placed a unilateral nasal canula delivering oxygen. The C-Arm overarches the patient, and both the screen of the radiology machine and the anesthetist are placed headside. The surgeon directly faces the patient on the side of the pain with the instrument table and the RF machine lateral to him. The RF machine allows for complete control of the current for stimulation. Frequencies of 5Hz are used to be able to see masticatory and trigemino-facial reflexes. Sensory threshold should be below 400mV and is carefully controlled. The machine is then switched to radio frequencies to create the thermal lesion. The probe has a thermiresistance, the temperature should be kept below 75 degrees | yes |
PMC9603372 | Figure_4 | oa_package/95/6d/PMC9603372.tar.gz | ['Hence, we examined macrophage activation status at 4 weeks postinfection when we noticed the differences in pathogenesis as a symptom (', 'At the same time, no difference was observed in the M2 marker CD206 (MMR) (', ' 4A to E).', 'FIG 4Ear dermis CD11b+ Ly6G F4/80+ macrophages upregulate the expression of CD38 and CD69 at 4 weeks after 5-ASKH infection.'] | FIG4 Ear dermis CD11b Ly6G F4/80 macrophages upregulate the expression of CD38 and CD69 at 4 weeks after 5-ASKH infection. C57BL/6 Rag2 mice were infected in the ear dermis with 510 5-ASKH or FV9 metacyclic promastigotes, and the ear tissues were processed and phenotyped by flow cytometry at 4 weeks postinfection. (A) Illustration of the experimental design. (B) Representative flow cytometry dot plots with CD38 and CD69 expression by CD11b Ly6G F4/80 macrophages, namely, control (left), FV9 (middle), and 5-ASKH infection (right). (C) The corresponding MFI of the representative experiment. (D) Representative histogram showing MHC-II and CD206 expression by CD11b Ly6G F4/80 macrophages. (E) The corresponding MFIs. Results are shown as mean SD, and data are representative of 3 independent experiments with 3 to 5 mice/group. ** , 0.001; and *** , 0.0001 comparing infection groups. | yes |
PMC10608316 | Figure_7 | oa_package/15/bc/PMC10608316.tar.gz | ['The most typical imaging findings are a para-uterine mass with a twisted pedicle, vascular flow absence, and mild free abdominal fluid () [50,51].', 'Torsion of a leiomyoma in a 36-year-old woman with acute abdominal and pelvic pain.'] | Figure 7 Torsion of a leiomyoma in a 36-year-old woman with acute abdominal and pelvic pain. US ( , ) shows a normal uterus (yellow arrows) surrounded by multiple dilated vessels. In a previous MR ( ), a large pedunculated leiomyoma was observed (blue arrows). In a CT scan ( ), two pedunculated fibroids are seen; the right one is relatively hypodense, with free fluid in the paracolic gutter (red arrow). Surgery findings confirmed the diagnosis of leiomyoma torsion. | yes |
PMC3134682 | Figure_2 | oa_package/b9/a4/PMC3134682.tar.gz | ['8cm consistent with aldosteronoma ().', '.'] | Figure 2. Histopathology (H&E, 100X) of right adrenal gland nodule after right adrenalectomy is consistent with APA. | yes |
PMC3925298 | Figure_4 | oa_package/d5/c4/PMC3925298.tar.gz | [' 4a).', ' 4b).', ' 4b).', ' 4c).', ' 4c).', '', 'CD mice in each time point by ANOVA and Wilcoxon test)\nThe effects of TUDCA pretreatment for liver regeneration in mice with simple hepatic steatosisWe established a hypothesis that delayed liver regeneration shown in HFD mice is related with ER stress.'] | Fig.4 Enhanced ER stress was observed in simple fatty liver during liver regeneration. The mRNA levels of ER stress-related genes, GRP78, IRE1, ATF6, PERK, sXBP-1, and CHOP measured by real-time RT-PCR. The expression of GRP78 protein detected by Western blotting and immunohistochemical staining (original magnification 100). The expression of sXBP-1 protein detected by Western blotting and immunohistochemical staining (original magnification 200) ( Control, HFD, =58; meanSE, * <0.05 and ** <0.01 HFD mice vs. CD mice in each time point by ANOVA and Wilcoxon test) | yes |
PMC11116313 | Figure_6 | oa_package/3f/46/PMC11116313.tar.gz | ['H Dermoscopy 34 days after treatmentHIFU TreatmentHIFU treatments were performed using a System ONE-M (TOOsonix A/S, Hoersholm, Denmark) operating at 20 MHz, designed specifically for dermatological applications.', ' 6C, D).', ' 6E, F), with some of them ruptured.', ' 6G, H).'] | Fig.6 Cryotherapy treated lesion on left hand. Macroscopic view before treatment. Dermoscopy before treatment. Macroscopic view just after treatment. Dermoscopy just after treatment. Macroscopic view 5days after treatment. Dermoscopy 5days after treatment. Macroscopic view 34days after treatment. Dermoscopy 34days after treatment | yes |
PMC9724541 | Figure_1 | oa_package/ba/32/PMC9724541.tar.gz | ['\nComputed tomography image of paranasal sinuses.'] | Figure 1 A: Cross-sectional images; B: Sagittal images; C: Coronal images. | yes |
PMC8340493 | Figure_4 | oa_package/27/5c/PMC8340493.tar.gz | [' 4).', 'Pathological tau burden in normal and cognitively impaired subjects across the aging spectrum.', '73)DiscussionSince the neuropathological criteria for PART were proposed, the terminology has been widely adopted, but controversy persists, especially around its relationship to Alzheimer disease (AD).'] | Fig. 4 Pathological tau burden in normal and cognitively impaired subjects across the aging spectrum Generalized linear models of age versus tau burden show significant differences between cognitively normal and cognitively impaired subjects in the hippocampus proper ( =0.047), and combined entorhinal region and hippocampus regions ( <0.048), but not in the entorhinal region alone ( =0.07). Generalized linear model of age vs Braak NFT staging did not show significant differences between cognitively normal and cognitively impaired subjects ( =0.73) | yes |
PMC2874258 | Figure_3 | oa_package/23/e3/PMC2874258.tar.gz | ['Capillary amyloid angiopathy.'] | Figure 3 . Pan-amyloid-beta (pan-A) immunohistochemistry. A diffuse plaque of A in cerebral cortex with a capillary, devoid of A, running through it. Cortical capillaries are surrounded by a thin layer of A corresponding to the perivascular basement membrane with attached globular deposits of A (Drusen) continuous with A in the capillary wall. Globular A Drusen partly surround the capillary wall. Confocal images were stained with thioflavin S. Histological section of a cortical capillary with a spiky Druse of amyloid continuous with amyloid in the capillary wall. Smear preparations of multiple globular Drusen and filiform deposits of amyloid attached to cortical capillaries whose walls also stain for amyloid. Higher magnification shows continuity of the filaments with amyloid in the capillary wall. Scale bars = 20 m (a-d, f-h) and 10 m (e). Reprinted with permission from John Wiley & Sons, Inc. [ ]. | yes |
PMC5563341 | Figure_7 | oa_package/f5/79/PMC5563341.tar.gz | [' 7a).', ' 7a).', '', 'Images of representative stainings are shown\nThese autoBLCL-reactive T cells are potentially enriched in brain tissue due to local stimulation by EBV proteins [53].', ' 7b).', ' 7c).', ' 7.'] | Fig.7 White matter lesion-derived CD8 T cells recognize autologous EpsteinBarr virus-transformed B cells and localize in the parenchyma to form immune synapses. Short-term T-cell lines (TCL) were generated by non-specific stimulation of T-cell recovered from paired cerebrospinal fluid (CSF) and white matter brain tissues from nine MS patients, which were immunohistologically classified defined as normal-appearing white matter (NAWM), diffuse white matter abnormalities (DWMA), active lesions (AL), mixed active/inactive lesions (mAIL) and inactive lesions (IL) (see Online Resource 3 for criteria applied for MS WM classification). The TCL were incubated with autologous EpsteinBarr virus-transformed B cell lines (autoBLCL). Next, the phenotype and frequency of autoBLCL-specific T cells was determined by co-expression of intracellular interferon gamma (IFN) and CD137 using multiplex flow cytometry. The frequency of autoBLCL-reactive T cells is shown as the percentage of IFN CD137 CD4 ( ) and CD8 T cells ( ). represent individual donors ( =9; specified in the legend) and vertical lines represent the mean and standard deviation of at least two independent experiments per TCL. Significance of variation in autoBLCL T-cell reactivity was determined by ANOVA for CD4 and CD8 T cells separately. TCL generated from two anatomically distinct mAIL of MS patient #6 (see Online Resource 1) were cultured with autoBLCL to assay the T-cell receptor variable chain (TCRV) usage of the reactive T cells, determined by intracellular interferon gamma (IFN) expression, using multiplex flow cytometry. The frequency of CD4 ( -axis) and CD8 T cells ( -axis) of specific TCRV families ( -axis) are depicted ( lesion #1, lesion #2). The frequency of autoBLCL-reactive CD4 T cells and CD8 T cells of each TCRV family is shown ( IFN T cells). Results shown are representative for two independent experiments. Und. refers to T cells expressing a TCRV chain not covered by the TCRV-family-specific monoclonal antibody panel used. Triple immunofluorescence staining for TCRV2 ( ), laminin ( ) and CD8 ( ) in surplus WML tissue sections (8m) containing WML #1 and #2, from which the corresponding TCLs shown in panel A were generated. Nuclei were stained with DAPI ( ). TCRV2 CD8 T cells reside in the perivascular cuff ( ) and the parenchyma ( ) of both distinct WML of the same patient. The majority of parenchymal T cells show polarization of both CD8 and TCRV2 ( ). Images of representative stainings are shown | yes |
PMC8597376 | Figure_6 | oa_package/80/17/PMC8597376.tar.gz | ['CD: Cluster of differentiation; CK: Cytokeratin; HE: Hematoxylin Eosin; F: FemaleCase No.'] | Figure 6 Case No. 3. F, 60-year-old. B2 thymoma. Morphological and immunohistochemical features: (a) Tumor made up of two distinct cellular populations clusters of large polygonal neoplastic epithelial cells setting on a background of numerous lymphocytes; the tumor presented a fibrous capsule infiltrated by tumoral cells; (b) Admixture of clusters of polygonal epithelial cells and lymphoid cells; the epithelial cells were larger than the lymphoid cells and presented hypochromatic nuclei with small nucleoli; the lymphocytes were uniform, with scant cytoplasm, round nuclei, and inconspicuous nucleoli; (c) Within the tumor there were some perivascular spaces centered by a venule surrounded by a clear space containing proteinaceous fluid; (d) CK19 immunoreactivity of neoplastic epithelial cells setting in a background of abundant lymphocytes; (e) CD20 immunostaining was positive in B-lymphocytes infiltrate and negative in the epithelial neoplastic component (immunoperoxidase with Hematoxylin counterstaining); (f) Strong CD5 immunopositivity of T-lymphocytes infiltrate, but negative in the epithelial neoplastic component (immunoperoxidase with Hematoxylin counterstaining); (g) Ki67 labeling index showed high values (>80%), but most of the nuclear staining represented T-lymphocytes; however, some larger epithelial cells were also immunopositive for Ki67; (h) Strong and diffuse immunopositivity for p63 in the tumoral epithelial cells. HE staining: (a and c) 40; (b) 100. Anti-CK19 antibody immunomarking: (d) 100. Anti-CD20 antibody immunomarking: (e) 400. Anti-CD5 antibody immunomarking: (f) 400. Anti-Ki67 antibody immunomarking: (g) 200. Anti-p63 antibody immunomarking: (h) 100. CD: Cluster of differentiation; CK: Cytokeratin; HE: HematoxylinEosin; F: Female | yes |
PMC10010779 | Figure_1 | oa_package/20/6f/PMC10010779.tar.gz | ['Abdominal contrast-enhanced computed tomography scans of the lesions in the left retroperitoneal region (white arrows).'] | Figure 1 Abdominal contrast-enhanced computed tomography scans of the lesions in the left retroperitoneal region (white arrows). (A and B) An ovoid thick-walled cystic lesion without calcification and enhancement in case 1. (C and D) A fusiform solid lesion with massive calcification in case 2. (E and F) An ovoid solid lesion with punctate calcification in case 3. | yes |
PMC8417297 | Figure_1 | oa_package/6b/0e/PMC8417297.tar.gz | ['Another oblong heterogeneous formation of 13 cm along the right psoas was found ().', 'Ultrasound of the urinary tract: Heterogeneous echogenic formation of the upper pole of the right kidney (A).', ''] | Fig. 1 Ultrasound of the urinary tract: Heterogeneous echogenic formation of the upper pole of the right kidney (A). Heterogeneous formation along the right psoas (B). | yes |
PMC4450267 | Figure_8 | oa_package/2e/7f/PMC4450267.tar.gz | ['Moreover, mice that received F4/80+MR+ cells displayed less signs of colitis, such as shortened colon, and tissue architecture was very well conserved in these mice (s 8(b)-8(c)) compared to mice that did not receive cells or mice that received F4/80+MR cells.', 'The transfer of F4/80+MR+ cells into DSS-treated mice was characterized by much less severe mucosal pathology than in mice that did not receive cells or mice that received F4/80+MR cells, as evidenced by marked destruction of the crypt architecture and a greater influx of inflammatory polymorphonuclear cells, which are largely associated with colitis (s 8(c)-8(d)); thus mice receiving F4/80+MR cells showed even worse pathology, with shorter colons and severe signs of cryptitis and loss of colon tissue architecture.', '007"/>F4/80+MR+-sorted peritoneal macrophages from T.'] | Figure 8 F4/80 MR -sorted peritoneal macrophages from -infected mice transferred intraperitoneally into nave mice inhibit the development of colitis. (a) F4/80 MR peritoneal macrophages sorted from -infected mice inhibit CD4 and CD8 T cell proliferation (data not shown for CD8). In contrast, sorted F4/80 MR macrophages from the same mice do not suppress CD4 cell proliferation. (b) Colon length of mice with ulcerative colitis that received F4/80 MR and F4/80 MR cells. (c) Infiltration of inflammation. (d) Histology of the effect of F4/80 MR adoptive transfer during colitis: magnification is 20x for all the slides shown. Bars represent the mean SD from three slides per mouse. < 0.05, < 0.003, = 5 mice per group. All data are representative of two independent experiments. | yes |
PMC10742688 | Figure_5 | oa_package/06/0f/PMC10742688.tar.gz | ['The stromal cells were slightly enlarged, sometimes multinucleated, with irregular nuclei demonstrating granular chromatin ().', 'IHC showed a diffuse expression of p16 and focal nuclear enhancement of MDM2 ().', 'Fibrous lesion with scattered atypical spindle cells and an adipocytic component (A); hematoxylin and eosin staining, original magnification 200 .'] | Figure 5 Fibrous lesion with scattered atypical spindle cells and an adipocytic component ( ); hematoxylin and eosin staining, original magnification 200. There is focal nuclear MDM2 expression in the atypical stroma cells ( ); original magnification 400. | yes |
PMC10083623 | Figure_1 | oa_package/71/39/PMC10083623.tar.gz | [' (paratracheal line) (A).', '4 cm (B) (', ' (right paratracheal) (C, *) (extrinsic invasion) (', ' 1 , 2 (D, ) (', ' (percutaenous cutting needle biopsy) - (E, left) (immunohistochemistry staining) nuclear protein in testis ( NUT) p63 (', ' 2 (F) 6 ( ) .', ' - (nuclear to cytoplasm) (monotonous) (round to oval) (E, left).', ' (immunohistochemistry) thyroid transcription factor-1 (TTF-1) (pneumocyte) , p63 NUT (squamous differentiation) NMC (E, right).', 'Funding: None1\nKubonishiI\nTakeharaN\nIwataJ\nSonobeH\nOhtsukiY\nAbeT\n\nNovel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinomaCancer Res1991513327332820400072\nBauerDE\nMitchellCM\nStraitKM\nLathanCS\nStelowEB\nL erSC\n\nClinicopathologic features and long-term outcomes of NUT midline carcinomaClin Cancer Res20121857735779228966553\nJungM\nKimS\nLeeJK\nYoonSO\nParkHS\nHongSW\n\nClinicopathological and preclinical findings of NUT carcinoma: a multicenter studyOncologist201924e740e748306967214\nChangAI\nKimTS\nHanJ\nKimTJ\nChoiJY\nNUT midline carcinoma of the lung: computed tomography findings in 10 patientsJ Comput Assist Tomogr202145330336336611515\nShollLM\nNishinoM\nPokharelS\nMino-KenudsonM\nFrenchCA\nJannePA\n\nPrimary pulmonary NUT midline carcinoma: clinical, radiographic, and pathologic characterizationsJ Thorac Oncol201510951959260011446\nChoYA\nChoiYL\nHwangI\nLeeK\nChoJH\nHanJ\nClinicopathological characteristics of primary lung nuclear protein in testis carcinoma: a single-institute experience of 10 casesThorac Cancer20201132053212330098767\nFrenchCA\nMiyoshiI\nKubonishiI\nGrierHE\nPerez-AtaydeAR\nFletcherJA\nBRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinomaCancer Res200363304307125437798\nPolsaniA\nBraithwaiteKA\nAlazrakiAL\nAbramowskyC\nShehataBM\nNUT midline carcinoma: an imaging case series and review of literaturePediatr Radiol201242205210220338569\nBairRJ\nChickJF\nChauhanNR\nFrenchC\nMadanR\nDemystifying NUT midline carcinoma: radiologic and pathologic correlations of an aggressive malignancyAJR Am J Roentgenol2014203W391W3992524796810\nChauNG\nMaC\nDangaK\nAl-SayeghH\nNardiV\nBarretteR\n\nAn anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patientsJNCI Cancer Spectr20194pkz09432328562Images of pulmonary nuclear protein in testis midline carcinoma in an 25-year-old female.'] | Fig. 1 Images of pulmonary nuclear protein in testis midline carcinoma in an 25-year-old female. Chest radiograph shows a large homogenous round mass in the right middle lung field. An area of diffuse fusiform-shaped increased density is visible at the right paratracheal region. Chest CT with lung window setting shows a 4.4-cm well demarcated mass with a thin linear pleural tail in the right upper lobe. Enhanced chest CT with mediastinal window setting shows a mass with an eccentric low density (arrowhead). Coalescent lymph node metastasis (*) is noted in the right lower paratracheal region resulting in compression of the superior vena cava and close attachment of the right mainstem bronchus (arrow). Bone window setting images show osteolytic metastasis in the right scapular (arrowheads) and T1 and T2 vertebral bodies (arrows). Photomicrographic images of pulmonary NUT midline carcinoma. The tumor cells show multiple, monotonous, small to mid-size, and round to oval nuclei with a high ratio of nucleus to cytoplasm (left; hematoxylin and eosin stain, 400). Immunohistochemical staining for NUT (nuclear protein in testis) is positive ( 400) (right). The pathologic diagnosis is pulmonary NUT midline carcinoma. Follow-up chest radiograph performed on the 14th hospital day shows a new fracture of the right 6th rib and regional fusiform shaped cortical thickening (arrow). NUT = nuclear portein in testis | yes |
PMC10747561 | Figure_6 | oa_package/a2/c0/PMC10747561.tar.gz | ['Positive IHC staining appeared as dark red deposits in the nuclei of exfoliating epithelial cells in the trachea, alveolar epithelial cells in the lung, and more so in the cytoplasm of the renal tubular epithelium ().', 'Immunohistochemical staining dpi 5.'] | Figure 6 Immunohistochemical staining dpi 5. ( ) Visible dark red deposits in the nuclei of the exfoliating epithelial cells in the trachea. H&E counterstain, 40, bar = 50 m. ( ) Dark red virus antigen in the exfoliating alveolar epithelial cells in the lung. H&E counterstain, 40, bar = 50 m. ( ) Dark red deposits in the cytoplasm of the renal tubular epithelium in the kidney. H&E counterstain, 40, bar = 50 m. | yes |
PMC8405316 | Figure_3 | oa_package/3a/5d/PMC8405316.tar.gz | ['002"/>Right AMF at reconstructed CBCT.'] | Figure 3 Right AMF at reconstructed CBCT. | yes |
PMC6886787 | Figure_2 | oa_package/b7/a4/PMC6886787.tar.gz | ['Representative cases are shown in .', 'g002Representative cases of each approximated TCGA molecular subtype.'] | 10.1371/journal.pone.0224812.g002 | yes |
PMC11086593 | Figure_4 | oa_package/c7/82/PMC11086593.tar.gz | ['475) (Table 1) ().', 'Relationship between nodule size and Bethesda Categories I (ND) and III (AUS) distribution of nodule size in both categories.'] | Figure 4 Relationship between nodule size and Bethesda Categories I (ND) and III (AUS)distribution of nodule size in both categories. No statistically significant relationship was observed between nodule size and Bethesda categories I and III ( = 0.321). ND: Nondiagnostic, AUS: Atypia of Undetermined Significance, TBSRTC: The Bethesda System for Reporting Thyroid Cytopathology. | yes |
PMC10247946 | Figure_7 | oa_package/a7/46/PMC10247946.tar.gz | [' 7).', 'Embolisation of GDA aneurysm by sandwich occlusion technique with micro coils.', '018 coilsConclusionsTrue VAAs are uncommon but have the potential for rupture and death.'] | Fig. 7 Embolisation of GDA aneurysm by sandwich occlusion technique with micro coils. GDA aneurysm on selective angiogram of the celiac axis with associated replaced right hepatic artery arising from the GDA at the neck of the aneurysm. Embolisation of the front and back doors of the GDA aneurysm as well as the replaced right hepatic artery using 4, 5 and 6mm detachable 0.018 coils | yes |
PMC3789892 | Figure_8 | oa_package/b0/56/PMC3789892.tar.gz | [' 8d).', '', 'Scale bars represent 10 m in each panel\nRecruitment of microglia in the OB 1.', ' 8a), we observed t -syn in the perikarya of microglia in the OB at later timepoints, from 1.', ' 8b d).', 'pdf">Supplementary (PDF 376 kb)\n<media xlink:href="401_2013_1160_MOESM10_ESM.'] | Fig.8 T-syn is localized within microglia already 1.5h after injection into the OB. T-syn was identified by its ATTO-550 fluorescent tag ( ), and microglial cells by Iba1 staining ( ) by confocal microscopy. At 20min after injection of oligomers, no Iba1-positive cell containing ATTO-550 signal was detected . After 1.5h, confocal three-dimensional reconstructions show ATTO-550 signal ( ) colocalized with Iba1 ( ) also within microglia in the OB of mice injected with oligomers at 1.5h , 3h and 72h timepoints, indicating that these cells contain hu-syn. represent 10m in each panel | yes |
PMC4215469 | Figure_1 | oa_package/88/f7/PMC4215469.tar.gz | ['Volume of the DN (expressed as fraction of TICV) was significantly smaller in patients compared to controls (, FA: 0.', '; R2 , R = 0.', '; R2 , R = 0.', '; ANOVA; group effect, F(1) = 579.', '; ANOVA; group effect, F(1) = 579.'] | Fig.1 A. DN of a patient (number 8 in ) and B. a control (different window levels). In the FA-patient the nucleus is smaller and the gray matter ribbon is less distinct than in the normal dentate nucleus. | yes |
PMC10443806 | Figure_3 | oa_package/cc/f4/PMC10443806.tar.gz | ['Following treatment with HS-276, TGF- 1 treated fibroblasts showed marked reduction in COL1A2, COL3A1, and ACTA2 expression (A and Supplemental ).', 'Furthermore, HS-276 blocked TGF- 1 induced upregulation of smooth muscle actin ( -SMA), collagen I, Fn-EDA, and tenascin-C (, B and C).', 'HS-276 inhibited TGF- dependent fibrotic cellular responses.'] | Figure 3 HS-276 inhibited TGF-dependent fibrotic cellular responses. Confluent foreskin fibroblasts were incubated with TGF-1 (10 ng/mL) for 24 hours in the presence or absence of HS-276 (10 M). ( ) qPCR. Levels were normalized with GAPDH. ( ) Whole-cell lysates examined by immunoblotting; representative immunoblots. Relative fold change compared with control, normalized with GAPDH. ( ) Fibroblasts were immunolabeled using antibodies to procollagen I, ASMA, or Fn-EDA. Representative images. Scale bar: 10 m (top panel) or 50 m (bottom panel). Quantification of relative fluorescence intensities (means SEM from 3 randomly selected regions). | yes |
PMC11588189 | Figure_9 | oa_package/54/71/PMC11588189.tar.gz | ['0, respectively [ a-<xref rid="ijt.', 'ijt_40_22-f009">a: Early stage of FPHL (H E,10X)with Increase in size of sebaceous glands [horizontal section]; b: Advanced stage of FPHL(H E,10X) showing severe miniaturization, disruption of follicular units and diminished sebaceous glands [horizontal section]DISCUSSIONFPHL is becoming an increasingly prevalent condition in the present times due to a shift in the patients profile with respect to lifestyle modifications, cosmetic habits, hormonal disorders, increase in psychological stress levels, increasing awareness, and a peer-pressure-driven compulsion to look good.'] | Figure 9 a: Early stage of FPHL (H&E,10X)with Increase in size of sebaceous glands [horizontal section]; b: Advanced stage of FPHL(H&E,10X) showing severe miniaturization, disruption of follicular units and diminished sebaceous glands [horizontal section] | yes |
PMC8504230 | Figure_3 | oa_package/a0/64/PMC8504230.tar.gz | ['The low-grade DDLPS with multiple foci can be seen, which suddenly transits to the high-grade DDLPS ((d) and (f)).', '.', '1177_20587384211048565-fig3" position="float"/>.'] | Figure 3. Histologic analysis of dedifferentiated liposarcoma specimens. (a) Typical well-differentiated liposarcoma of the adipocytic/lipoma-like type (hematoxylineosin stain; 100). (b) High-grade dedifferentiated liposarcoma demonstrates high cellularity, pleomorphism, and marked cellular atypia (hematoxylineosin stain; 100). (c) and (d) Transition from low-grade dedifferentiation with inflammatory myofibroblastic tumor-like features to high-grade dedifferentiation with undifferentiated pleomorphic sarcoma features (hematoxylineosin stain; c 40). The boundary (white arrows) between them is clear (hematoxylineosin stain; d 20). (e) and (f) Transition from low-grade dedifferentiation with fibromatosis-like features to high-grade dedifferentiation with undifferentiated pleomorphic sarcoma features (hematoxylineosin stain; e40). The boundary (white arrows) between them is clear (hematoxylineosin stain; f 20). | yes |
PMC4855003 | Figure_1 | oa_package/c3/a4/PMC4855003.tar.gz | ['As you can see in , the CT scan reported significant thickening in the sigmoid colon.', '0-3734906933018097129CT scan 5 months before surgery.'] | Figure 1 CT scan 5 months before surgery. | yes |
PMC8219441 | Figure_5 | oa_package/ce/b7/PMC8219441.tar.gz | ['004"/>(a, b) Intraoperative images demonstrating the insertion of K-wires to hold the talonavicular joint reduction and addition of 2.'] | Figure 5 (a, b) Intraoperative images demonstrating the insertion of K-wires to hold the talonavicular joint reduction and addition of 2.7mm screws in the constant fragment in order to reconstruct the anatomy of the navicular; the K-wires help to keep dislocation forces off of the screw fixation to avoid failure of the navicular screw fixation. | yes |
PMC5724866 | Figure_4 | oa_package/cd/9d/PMC5724866.tar.gz | ['0001) ( and s F and G in <xref ref-type="supplementary-material" rid="pone.', 'g004NAC treatment reduces the quantifiable levels of chronic inflammation in the L2LMP1 transgenic mice.'] | 10.1371/journal.pone.0189167.g004 | yes |
PMC8698479 | Figure_3 | oa_package/62/45/PMC8698479.tar.gz | ['The average ABR waveforms elicited by all tone-burst frequencies at 80 dB SPL (A) showed strong reduction in the amplitude of all waves, except for wave V elicited by 16 kHz at 30 min following impulse noise exposure.', 'Four weeks after exposure, while an almost complete recovery in the amplitude of wave V and peaks I and II still remained smaller than pre-exposure (A), suggesting that a compensatory mechanism might have affected central processing, mean ABR amplitudes elicited by 4, 8, 16 and 32 kHz tone-bursts at 60 (B, red plots) and 80 dB SPL (B, black plots), showed a significant reduction in wave I amplitudes until 4 weeks after exposure (B), except for 16 kHz at 80 dB SPL stimulus, where a complete recovery was seen after 24 h (B).', 'In addition, a significant increase in the V/I wave ratio was observed for all tone-burst frequencies at 60 or 80 dB SPL stimulus by 24 h, and maintained to 4 weeks after exposure for 8, 16 and 32 kHz (C).', '05, C).', 'Impulse-noise effect on the amplitude of ABR waves.'] | Figure 3 Impulse-noise effect on the amplitude of ABR waves. ( ): Mean ABR waveforms evoked by 4, 8, 16 and 32 kHz tone bursts at 80 dB SPL, and recorded before (blue), 30 min (red), and 4 weeks (gray) after impulse-noise exposure. ( ): ABR Wave I amplitudes evoked by 4, 8, 16 and 32 kHz tone bursts at 60 dB SPL (red), and 80 dB SPL (black), and recorded before, 30 min, 24 h or 4 weeks after impulse-noise exposure. Two-way ANOVA test was followed by Dunnetts multiple comparison: * 0.05, ** 0.01, *** 0.001, time after noise exposure vs. before. ( ): Mean ABR Wave V/I amplitude ratios recorded before, 24 h, or 4 weeks after impulse noise-exposure at 60 dB SPL (red), or 80 dB SPL (black). ABR waves V/I ratio failed to pass the normality test, so Friedman ANOVA was followed by Dunns multiple comparison test: * 0.05, ** 0.01, *** 0.001, time after noise exposure vs. before. All data are expressed as mean SEM ( = 22 cochleae per time point). | yes |
PMC4929366 | Figure_2 | oa_package/2a/d8/PMC4929366.tar.gz | ['Preoperative CT scan demonstrating a dilated appendix abutting the right side of the rectal wall.'] | Fig. 2 Preoperative CT scan demonstrating a dilated appendix abutting the right side of the rectal wall. | yes |
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