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cc-by | The relevance labels on the testing data (required by active learning techniques) were provided to participants on 1 May 2018, four days before the submission deadline so that participants could not tune their systems towards the actual labels. Task 3 had seven teams submitting runs: one team from Australia (QUT), one ... | 10.1007/978-3-319-44564-9_24 | book-chapter | en | 2,016 | true | false | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Test collections generated by each of the three CLEF eHealth 2018 tasks offered a specific task definition, implemented in a dataset distributed together with an implementation of relevant evaluation metrics to allow for direct comparability of the results reported by systems evaluated on the collections. The establish... | 10.1007/978-3-319-44564-9_24 | book-chapter | en | 2,016 | true | false | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Acknowledgements. The CLEF eHealth 2018 evaluation lab has been supported in part by (in alphabetical order) the ANU , the CLEF Initiative , the Data61/ CSIRO , and the French National Research Agency (ANR) , under grant CABeRneT ANR-13-JS02-0009-01. We are also thankful to the people involved in the annotation, qu... | 10.1007/978-3-319-44564-9_24 | book-chapter | en | 2,016 | false | false | true | false | Computer Science | https://openalex.org/fields/17 |
cc-by | The enterprise level software application that supports the strategic product-centric, lifecycle-oriented and information-driven Product Lifecycle Management business approach should enable engineers to develop and manage requirements within a Functional Digital Mock-Up. The integrated, model-based product design ENOVI... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | false | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | In 1990, Gero [1] proposed the FBS ontology where F stands for the set of functions, B for the set of expected behaviours (Be) and the set of actual behaviours (Bs), and S for the structure. In [2] , Christophe extends the FBS ontology to RFBS by including the R for requirements. Back in the nineties, in his theory ... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | false | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | The R is for ENOVIA V6 Requirements, a requirements management workbench. The F, L and P layers are used to recursively break down the complexity of the design problem according to the Functional, Logical and Physical viewpoints of the product. This design approach follows from Descartes' reductionism method that consi... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | false | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | g. Word, PDFand 79 % of requirements are written in unrestricted natural language [8]. For all these reasons, in a "buy approach" of a "make vs buy" decision, OEMs struggle to deliver products that comply with the legal and contractor's requirements. Indeed, when an OEM collects the specifications and the applicable d... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | false | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | However, in a "buy approach", the OEM has to move the requirements from the unstructured specification documents to the ENOVIA V6 Requirement database and manually build requirements' knowledge parameters. | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | true | false | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | From Unstructured Specifications to PPBRs Before presenting the NLP pipeline that generates the PBRs, we must present the concepts of PBR and PPBR. As Micouin introduces in [13] , a PBR is an unambiguous formal definition of a requirement as a predicate and is defined as follows: PBR : When C ! val O:P ð Þ 2 D ð1Þ Thi... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | false | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | Step 13 <PBRs Modelling>: The NLP pipeline ends up with an XML specification that lists the PBRs in a structure that complies with the PPBRs data model in ENOVIA V6 Requirements. Thus, each PBR element has a statement, a nominal value, a minimal value and a maximum value that specify a domain D that can be inferred fro... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | true | true | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | 3 Case Study 3. 1 From Unstructured Specifications to PPBRs First, we put ourselves in the shoes of a contractor who wants to acquire a mechanical ring. We only write three requirements 10 to ease the illustration of our proposition. Each requirement is in a different specification (. doc,. pdf and SysML). Then, we p... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | true | false | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | Results and Limitations We conducted experiments with both real industrial and handcrafted data sets. The initial results that we obtained after analysing handcrafted specifications are encouraging. One key factor is that we wrote the requirements by following the requirements writing best practices defined in [19]. R... | 10.1007/978-3-319-33111-9_19 | book-chapter | en | 2,016 | true | false | false | false | Engineering | https://openalex.org/fields/22 |
cc-by | Acknowledgments The authors acknowledge financial help from Ministerio de Ciencia y Técnica, Agencia Nacional de Promoción Científica y Tecnológica, MINCyT-ANPCyT-FONCyT through PICT/2014-0585 , and through FONARSEC FSNano-008 FSNano-008. R. M. T. S. is a member of CONICET and F. M. F. and M. G. acknowledge CO... | 10.1016/j.clay.2016.02.034 | article | en | 2,016 | false | false | true | false | Chemistry | https://openalex.org/fields/16 |
cc-by | IFDS: implementation As mentioned in the previous section, IFDS was implemented with SNMP and Web Services. SNMP is used by the Monitor and Monitored Hosts to exchange messages and each Monitored Host must be registered on the fdMIB, shown in Fig. 4. fdMIB consists of three groups: the Monitor Host Group, Monitored Hos... | 10.1186/s13174-016-0051-y | article | en | 2,016 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Experimental results: LAN The LAN experiments were executed on two hosts: the monitor host was based on an Intel Core i5 2. 50 GHz processor, with 4 GB of RAM, running Linux Ubuntu 12. 04 with kernel 3. 2. 0-58; the monitored host was an Intel Core i5 CPU 3. 20 GHz, with 4 GB RAM running Linux Ubuntu 13. 10 with kernel... | 10.1186/s13174-016-0051-y | article | en | 2,016 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Acknowledgements This work was partially supported by grants 309143/2012-8 and 141714/2014-0 from the Brazilian Research Agency (CNPq). | 10.1186/s13174-016-0051-y | article | en | 2,016 | false | false | true | false | Computer Science | https://openalex.org/fields/17 |
cc-by | For client-side JavaScript programs, this definition of API applies both to: (1) interfaces of services that are provided to the program by the environment in which it executes, namely the web browser (for instance, the DOM, the XMLHttpRequest, and the W3C Geolocation APIs); (2) interfaces of JavaScript libraries that ... | 10.1007/978-3-319-28766-9_4 | book-chapter | en | 2,016 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Runtime API Register. We assume the existence of a runtime function called the runtime API register, that simulates the API Register, which we denote by $apiRegister. The function $apiRegister makes use of the domain method of each API in its range to decide whether there is an API relation associated with its inputs, ... | 10.1007/978-3-319-28766-9_4 | book-chapter | en | 2,016 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | The object µ(r 0 ) is updated by shifting by -1 all the indexes equal to or higher than i (the index of the object being removed) and by removing index n. The levels of the indexes of the right siblings of the node to remove are accordingly shifted by -1. The constraint of the rule prevents a program from removing in a... | 10.1007/978-3-319-28766-9_4 | book-chapter | en | 2,016 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Acknowledgment. Portions of this work were presented at the SPIE Photonics Europe Conference in 2016, Photonics and Digital Technologies for Imaging Applications IV , 989605. | 10.1364/ol.41.005426 | article | en | 2,016 | false | false | true | false | Engineering | https://openalex.org/fields/22 |
cc-by | These steps are described herein. To illustrate the operationalization of each step, we have proposed a case study in the flight tickets e-commerce domain in a traditional airline company, showing how the approach can support the testing of Prototypes and Final UIs. This case was chosen because it is easily comprehensi... | 10.7250/csimq.2016-7.05 | article | en | 2,016 | true | false | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | All the findings here are even more encouraging as they were obtained with a lowresolution 64-taxel TVSS device. Behavioural data obtained in our experiments give credence to further experiments on biological substrates of sensory substitution evaluated by neuro-imagery. In addition, not only the PTD version of the TVS... | 10.1068/p6339 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Acknowledgments. This research was supported by the European Commission Quality of Life contract QLG-3CT-2000-01797 , ' Brain Plasticity and Sensory Substitution in Human Blindness '. We gratefully thank Laurence de Lussy-Kubisa and Vincent Chrétiennot for their assistance and/or technical help, and the voluntee... | 10.1068/p6339 | article | en | 2,013 | false | false | true | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | The integration time per pixel is set to 10 ms in order to increase the total number of photons recorded and therefore the accuracy of spot center determination. The center position of each SHG spot is retrieved by a Gaussian fit of a spot image profiles along its main symmetry axes. SHG image spots of round shape exhi... | 10.1364/oe.21.012318 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments The authors thank Jérôme Wenger and Hervé Rigneault for fruitful discussions. This work has been supported by the French National Research Agency (NLOShaping JC07-195504 ), the Conseil Régional de Provence Alpes Côte d'Azur and Champagne-Ardenne , the CNRS-Weizmann NaBi European associated labo... | 10.1364/oe.21.012318 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Aortic sinus quantification The lesions were estimated according to Paigen and collaborators [8] Briefly, each heart was frozen on a cryostat mount with OCT compound (Tissue-Tek), and stored at -80°C. Hearts were cut using a Leica CM3050S cryostat. Fifty sections of 10-μm thickness were prepared from the top of the l... | 10.1186/1743-7075-10-67 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis All results are presented as means ± SEM. Comparisons between groups were made using the Mann-Whitney test for independent samples. Outcomes of p < 0. 05 were considered significant. Analyses were performed using GraphPad Prism 6 software. | 10.1186/1743-7075-10-67 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank the technical service of the animal facility ( Genotoul Anexplo Platform, Toulouse ). We thank J. Bertrand-Michel and V. Roques ( MetaToul-Lipidomic Core Facility INSERM UMR 1048, France, part of Toulouse Metatoul Plateform ) and Eric Lacoste ( Synelvia, Prologue Biotech, Labège, France )... | 10.1186/1743-7075-10-67 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | 0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. processed through a GEANT4 [19] simulation of the full ATLAS detector [20] , and the same reconstruction and analysis software is used for both the data and the MC eve... | 10.1103/physrevlett.111.232002 | article | en | 2,013 | false | true | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | In this work, we introduce and evaluate a data assimilation framework for gauged and radar altimetrybased discharge and water levels applied to a large scale hydrologic-hydrodynamic model for stream flow forecasts over the Amazon River basin. We used the process-based hydrological model called MGB-IPH coupled with a ri... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | g. Thielen et al. , 2009; Alfieri et al. , 2013) still do not incorporate advanced data assimilation systems for updating model initial states. Also, the assimilation of discharge and water levels from in situ and remotely sensed observations into regional/global hydrologichydrodynamic models is still uncommon. In thi... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Model implementation We used a MGB-IPH implementation on the Amazon basin developed by Paiva et al. (2013b) , as briefly described below. The model was forced using meteorological data obtained from the CRU CL 2. 0 dataset (New et al. , 2002) and remotely sensed precipitation estimates from the TRMM 3B42 v6 product ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Discharge and water level observations We evaluated the assimilation of three types of data: (1) in situ discharge observations; (2) remotely sensed water levels derived from the ENVISAT radar altimeter; and (3) remotely sensed discharge estimates derived from radar altimetry water levels and rating curves. In situ dai... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | The ENVISAT satellite has a 35day repeat orbit and an 80 km inter-track distance at the Equator. The database used is an extension of the one presented in Santos da Silva et al. (2010) , consisting in 212 altimetry stations (AS -deduced from the intersection of a satellite track with a water body) with water level tim... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | The stage-discharge relations at each AS were built based on satellite altimetry and outputs from a global flow routing (GFR) scheme (Getirana et al. , 2012). A second experiment was performed by Getirana and Peters-Lidard (2013) using observed discharges at gauge stations to force the GFR scheme at downstream reaches... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Parameters of the DA scheme The first sensitivity experiments used the following standard parameters of the DA scheme. Ensemble size of the EnKF was set as N = 200. Precipitation fields were corrupted considering the following error parameters: precipitation relative error E = 25 %, and precipitation relative bias β = ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Data assimilation experiments We performed three data assimilation experiments, namely: (i) in situ discharge assimilation (Exp 1) (ii) Radar altimetry assimilation (Exp 2) and (iii) Assimilation of discharge series based on satellite altimetry (Exp 3). In the first experiment, we tested: (Exp. 1a) the assimilation of ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | 1a), but without transforming discharge into the log space (Sect. 2. 4. ). Moreover, we explored the sensitivity of the DA scheme to some of its parameters, namely the ensemble size N, precipitation relative error E and temporal and spatial decorrelation lengths of precipitation errors τ t , and τ x. The second experim... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Prospects of streamflow forecasting Hindcast streamflow forecasts were generated using an ensemble streamflow prediction (ESP) approach (Day, 1985) , as described below. The model uses an estimate of initial conditions derived from the DA scheme and runs forced by an ensemble of observed meteorological data from past ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | The DA scheme used the configuration from Exp. 1b where in situ discharge data were assimilated to update model states before starting a forecast. ESP runs generated decadal forecasts up to 90 days lead time and starting at every 1st, 10th and 20th day of the month for the two year period of 2004-2005. Aiming at explor... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | b Exp. 1a -data assimilation using discharge from 80 % of the stream gauges. c Exp. 1b -data assimilation using discharge from 10 % of the stream gauges. d Exp. 1c -equal Exp. 1a but without transforming discharge into the log space. to precipitation errors, although providing better results for data assimilation, may ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Radar altimetry data assimilation In this section, the assimilation of water levels derived from ENVISAT altimetry is evaluated (Exp. 2). Stage and discharge data observed at in situ gauging stations were used for validation purposes. The DA scheme improves water level simulations at altimetry stations used for assimil... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Assimilation of discharge series based on satellite altimetry In the last DA experiment (Exp. 3), we evaluate the assimilation of discharge data derived from ENVISAT water level. Therefore, the data assimilated into the model has the same high spatial coverage and low temporal sampling as altimetry water levels have, b... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Summary and conclusions We presented the development and evaluation of a data assimilation scheme for both gauged and satellite altimetrybased discharge and water levels into a large scale hydrologic-hydrodynamic model of the Amazon River basin using the Ensemble Kalman Filter -EnKF. We also evaluated hindcast forecast... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Acknowledgements. The authors are grateful for: the financial and operational support from the Brazilian agencies FINEP and ANA (" Projeto de Integracão e Cooperacão Amazônica para a Modernizacão do Monitoramento Hidrológico " ICA-MMH ) and CNPq-IRD (" Assimilacão de Dados de monitoramento Espacial para a análise ... | 10.5194/hess-17-2929-2013 | article | en | 2,013 | false | false | true | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | BW, MY and feeding After each milking, cows were automatically weighted (software RIC version RW1. 7). Only the morningLBW was used for weight analyses, because the afternoon BW was more variable. As LBW is affected by digestive contents, the estimation of EBW was corrected for the digestive tract content. A change of ... | 10.1017/s1751731112002133 | article | en | 2,012 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Statistical analyses Mean age at calving, mean EBW at the first wkpp and mean BVs for milk production and protein/fat content were compared between haplotypes with a Student T-test (TTEST procedure of the SAS software; SAS Institute Inc. , 2009). Results are presented as means 6 s. e. Data for zootechnical parameters (... | 10.1017/s1751731112002133 | article | en | 2,012 | true | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgements The authors thank the ANR Genanimal and Apis-Gene for financial support for the project. They also thank the staff of the Experimental Unit UEPAO at the INRA Nouzilly, Eric Briant , Mickael Dupont , Mickael Delanoue , Ludovic Me ´tivier and Christophe Mouaze , for animal management and their in... | 10.1017/s1751731112002133 | article | en | 2,012 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | STIMULI Stimuli were 54 fearful and 54 neutral adult faces selected from the FACES database (Ebner et al. , 2010). All faces belonged to different individuals in order to prevent subjects from subsequent false memory recognition of fearful/neutral stimuli sharing the same identity. To focus attention on facial emotion... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Faces were selected from the FACES database (Ebner et al. , 2010). a fake "Zero Tesla" MRI so they could become familiar with the machine, the noise, the response remote, and train to stay still. Figure 1 displays the fMRI experimental design. | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | IMAGING PROCEDURE Images were acquired on a 3-T Siemens Magnetom Trio scanner. High resolution 3D IR-prepped T1-weighted anatomic scans were first acquired (repetition time = 2300 ms, echo time = 3 ms, TI : 900 ms, 256-mm field of view, matrix 240 × 256, 160 sagittal slices, 1 × 1 × 1. 1 mm3) in 7 min 46 s. During enco... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Behavioral data Data were analyzed with Statistica (www. statsoft. com). Percents of correct and false recognitions were collected and averaged in each age group and a corrected memory accuracy measure was computed as %hits-%false recognition. Global effects of age (8-12 years vs. 13-17 years) were analyzed using 2 by ... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | fMRI data Individual GLM-based analyses were conducted with SPM5 (http://www. fil. ion. ucl. ac. uk/spm/). Trials were categorized in four types according to both emotional expression and recognition status (fearful hits, fearful misses, neutral hits, and neutral misses) based on individual memory performance and regre... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | With a larger number of subjects, however, age could have been considered as a continuous variable and regression analyses could have been conducted without any a priori statement on age-groups definition. Indeed, our results point to age-related changes around 12-13 years, but more gradual changes may occur within 9-1... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | We thus employed adult faces (young, middle age and older) from a larger database (Ebner et al. , 2010) ignoring the reported own-age bias, in which people recognize faces of people of their own age more accurately than faces of other ages (e. g. , Anastasi and Rhodes, 2005). Nevertheless, recent studies have shown ... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | ACKNOWLEDGMENTS This work was supported by a PhD grant to Charlotte Pinabiaux and a BQR grant to Pr. I. Jambaqué from the Paris Descartes University. We thank the nurses and technicians of the Laboratoire de Recherche Biomédicale (NeuroSpin, CEA ) for their help in participant's recruitment and organization of MR... | 10.3389/fnhum.2013.00901 | article | en | 2,013 | false | false | true | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Comparison with the observed activity pattern Here we compare the structures generated with our parameterized model to the observed structures used in Paper II. To do this, we use the spot and bright feature lists over cycle 23 that we retrieved from sunspot catalogues and MDI/SOHO magnetograms, respectively (Paper II)... | 10.1051/0004-6361/201219917 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Acknowledgements. We would like to thank our referee (X. Dumusque) for his very useful comments on the manuscript. | 10.1051/0004-6361/201219917 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | The oculomotor role of the basal ganglia has been supported by extensive evidence, although their role in scanning eye movements is poorly understood. Nineteen Parkinsons disease patients, which underwent implantation of deep brain stimulation electrodes, were investigated with simultaneous intraoperative microelectrod... | 10.1371/journal.pone.0078581 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Surgery and intraoperative microrecording Implantation of the deep brain stimulation system was performed separately in two steps: (i) stereotactic insertion of the permanent quadripolar electrode into the STN bilaterally and (ii) implantation of connection leads and the neurostimulator to the subclavial region. The Le... | 10.1371/journal.pone.0078581 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We are grateful to all the patients who participated in the study. We thank Marketa Fialova ´for administrative support, Martin Voleman for technical support, Henri Bonnet and Valerie Reeves for reviewing the manuscript. | 10.1371/journal.pone.0078581 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | FISH Probes. e 5S ribosomal probe corresponds to a partial sequence (87 bp) of the highly conserved 5S rRNA coding region, obtained from the genomic DNA of Chionodraco hamatus as described by Ghigliotti et al. [23]. A DNA fragment (1218 bp), obtained from the notothenioid Dissostichus mawsoni shotgun library of the BA... | 10.1155/2013/243938 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments e study was supported by the Italian National Programme for Antarctic Research (PNRA) and contributes to the SCAR Scienti�c Research Program EBA ( Evolution and Biodiversity in Antarctica ). Part of L. Ghigliotti 's work was supported by the L'Oreal-UNESCO program " For Women in Science" through... | 10.1155/2013/243938 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Future studies Despite agreement across the uro-radiology community that mpMRI has a potential future in the standard diagnostic pathway for CaP, differences in current conduct, interpretation, and reporting of mpMRI renders reliable comparison of research studies difficult [25, 26]. This is currently an impediment to... | 10.1016/j.urolonc.2012.02.004 | article | en | 2,012 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | gov NCT01292291). Targeting of biopsies to lesions identified on mpMRI is already in clinical use in a number of centers, but the techniques adopted are varied. Some groups use 'cognitive' registration of the results of the mpMRI to target biopsies on TRUS or transperineal prostate biopsies [28]. Prostate distortion a... | 10.1016/j.urolonc.2012.02.004 | article | en | 2,012 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Using DNA barcodes for assessing diversity in the family Hybotidae (Diptera, Empidoidea) efficient (correct) identification. Therefore, extra efforts are needed to increase the representation of hybotids in these databases. Second, the spatial scale of sampling has to be taken into account, and especially for widesprea... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | It has been made possible by extensive field collections carried out by the senior author (P. G. ), who has added substantially to material currently available from the Old World. DNA barcoding (Hebert et al. 2003) , based on a ca. 650 bp DNA region from the 5' end of the mitochondrial COI gene, is an easy-to-use mole... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | While there are over 500 COI sequences of Empidoidea in GenBank, we could only find a single, correctly classified Hybotidae sequence. Furthermore, although there are several DNA barcoding projects underway in North America that are analyzing large numbers of Hybotid species, sequence data from these studies have yet t... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Results Our sampling covered all the currently accepted subfamilies and tribes of the Hybotidae. At the generic level, we investigated 22 of the 66 known genera (see Table 1 for full details). The DNA sequence data set consisted of 341 COI sequences (339 Hybotidae and two Empididae), each sequence being of 657 bp in ... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | 2006 , best match and best close match criteria). An inherent problem with dipterans is the possibly high amount of unknown diversity on a global scale leading to incomplete databases, the substantial age of some large radiations that is linked to (very) high mitochondrial sequence diversity, and the limited taxonomic ... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The current dataset presented herein is a result of a pilot study focusing on Old World hybotid diversity. An overall high sequence divergence was observed in our dataset, which is not surprising in the light of the age and diversification pattern of dance flies (Wiegmann et al. 2003). Although most species could be w... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Second, large intraspecific distances and low interspecific distances among closely related species may pose a major problem, and even the use of refined criteria such as best close match (Meier et al. 2006) or ad hoc thresholds (Virgilio et al. 2012) might not solve this issue. Therefore, in datasets where intra-a... | 10.3897/zookeys.365.6070 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgements We thank Jean-Luc Renneson , Marc Pollet , Pol Limbourg , Alain Drumont (Belgium), Christophe Daugeron (France) , Rui Andrade (Portugal), Igor Shamshev and Semen Kustov (Russia) and Adrian Plant ( United Kingdom ) for their assistance. We also thank three anonymous reviewers for their const... | 10.3897/zookeys.365.6070 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgments Thanks are due to Pierre Villemur and Nathalie Moutier for helpful suggestions and discussion. This work was supported by the project " Patermed" coordinated by Stephane Anglès UMR 7533 LADYSS in the frame of the call ANR Systerra 2011-2014. | 10.5772/55312 | book-chapter | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments Thanks are due to Pierre Villemur and Nathalie Moutier for helpful suggestions and discussion. This work was supported by the project " Patermed" coordinated by Stephane Anglès UMR 7533 LADYSS in the frame of the call ANR Systerra 2011-2014. | 10.5772/55312 | book-chapter | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | There are a number of known drug interactions with potent inhibitors and inducers of cytochrome P450 3A4 due to a partial metabolism of rivaroxaban by this cytochrome (24). Two dose studies, the ODIXa-DVT (27) and EINSTEIN-DVT studies (28) , on the treatment of VTE suggest that the initial treatment of VTE requires... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | gov NCT00440193) found that rivaroxaban 15 mg twice daily for 21 days followed by 20 mg once daily was effective in the reduction of symptomatic recurrent venous thromboembolism after 6 months of treatment, in addition to the standard treatment regimen including parenterally administered enoxaparin for 5 days followed ... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Patients receiving initial antithrombotic therapy for DVT or PE were enrolled in the EINSTEIN-Extension study (clinicaltrials. gov NCT00439725), the results of which showed that rivaroxaban could be used for the long-term secondary prevention of VTE. Nevertheless, the risk of bleeding during long-term anticoagulant the... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | The efficacy and safety of rivaroxaban compared to enoxaparin were investigated for thrombosis prevention in hospitalized medically ill patients in the MAGELLAN program (clinicaltrials. gov NCT00571649). Although this study was completed in 2010, the results have not yet been published. Rivaroxaban was also assessed fo... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Apixaban is currently under evaluation for VTE prevention in patients hospitalized for an acute medical illness by the ADOPT phase III study (clinicaltrials. gov NCT00457002) and for VTE prevention in cancer patients by the ADVOCATE phase II study (clinicaltrials. gov NCT00320255). Following the BOTTICELLI DVT doserang... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Lower rates of bleeding and mortality were reported (Table 4 ). Indeed, the new anticoagulant reduces the risk of stroke or systemic embolism by 21%, major bleeding by 31%, and death by 11% compared to warfarin. Apixaban would prevent a haemorrhagic stroke in 4 patients per 1000 and an ischaemic or unknown type of str... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Betrixaban (PRT 054021, Portola Pharmaceuticals) at doses of 15 mg and 40 mg twice daily showed an effective antithrombotic action and was well tolerated by patients during the EXPERT phase II study ongoing in the US and Canada for the prevention of VTE after orthopaedic surgery for total knee replacement (Table 6 ) ... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Edoxaban Edoxaban (DU-176b, Daiichi Sankyo), another oral direct factor Xa inhibitor, is currently under investigation for the prevention and treatment of VTE and for the prevention of systemic thromboembolism in AF. The effectiveness of edoxaban as thromboprophylaxis for major orthopaedic surgery has been established ... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | gov NCT00986154) is designed to investigate the efficacy and safety of edoxaban for the initial treatment of VTE. There is no specific dose study, therefore it is not possible to speculate on a higher dosage during the first days of treatment followed by a subsequent dosage reduction, as for rivaroxaban and apixaban. I... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Darexaban A number of phase II and III studies (clinicaltrials. gov NCT00353678, NCT00913120, NCT00902928) investigate darexaban (YM150, Astellas Pharma) in VTE prevention after hip arthroplasty (49) (50) (51) and evaluate the superiority of the new anticoagulant over enoxaparin (PEARL-1, clinicaltrials. gov NCT00408... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Two phase II studies were designed to investigate an antithrombotic effect of the new drug in stroke prevention in patients with AF (clinicaltrials. gov NCT00448214 and OPAL-2, clinicaltrials. gov NCT00938730) (Table 4 ). Results were only published as abstracts (52, 53). The RUBY-1 study (clinicaltrials. gov NCT0099... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | TAK-442 Two dose-finding studies investigated the efficacy, safety and tolerability of TAK-442 (Takeda) in the prevention of VTE after total knee replacement and in the secondary prevention of ischemic vascular events in patients with ACS. In the first study (clinicaltrials. gov NCT00641732) recruitment was stopped ear... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | LY517717 In the phase II study (clinicaltrials. gov NCT00074828) LY517717 (Lilly), difumarate at doses of 100, 125 and 150 mg demonstrated noninferior efficacy and similar bleeding rates compared to enoxaparin in the prevention of venous thromboembolic events after orthopaedic surgery of the lower limbs (hip or knee re... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Eribaxaban Eribaxaban (PD 0348292, Pfizer) was assessed in a dose-ranging study (clinicaltrials. gov NCT00306254) for VTE prevention after total knee replacement. All doses were well tolerated. A dose-related increase in the incidence of bleeding events was not statistically significant (Table 6 ) (23). No informatio... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Otamixaban Otamixaban (XRP0673, Sanofi-Aventis) is a novel intravenous short-acting direct FXa inhibitor that can be used in acute situations. Initially evaluated in non-urgent percutaneous coronary intervention (SEPIA-PCI clinicaltrials. gov NCT00133731), this drug showed promising results in terms of efficacy and saf... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | The SEPIA-ACS1 TIMI 42 study recommended using intermediate doses of otamixaban in future studies as more appropriate: low doses were ineffective and high doses were shown to be dangerous. Treatment with otamixaban at doses of 0. 105 and 0. 140 mg/kg/h was associated with a 40% reduction in myocardial infarction, ischa... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | 5mg Warfarin (INR 2-3) Stroke or systemic 1. 27%/year vs Major bleeding 2. 13%/year vs 3. 09%/year randomized, double-blind years on average bid in selected embolism; death 1. 60%/year (p<0. 001) patients) from any cause (p<0. 001for non- inferiority, p=0. 01for superiority); 3. 52%/year vs 3. 94%/year (p=0. 047) Acety... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | 6%, 7. 8%, 3. 8%, 3. 0% randomized, double-blind months od, 30mg and (INR 2-3) relevant non-major for 60mg bid, 30mg bid, 60mg bid bleeding events 60mg od, 30mg od, respectively, vs 3. 2% ENGAGE-AF TIMI-48 / 20 500 / 24 30mg and 60mg Warfarin (INR 2-3) Stroke and systemic Underway Major bleeding Underway phase III, ran... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | 4% respectively, vs 2. 8% TAK-442 NCT00677053 / 2 753 / 24 weeks 40, 80 and 160mg Placebo + Composite of Underway Major bleeding events Underway phase II, od, 10, 20, 40, 80 antiplatelet cardiovascular defined by the randomized, and 120mg bid + therapy mortality, non-fatal thrombolysis in MI scale double-blind antiplat... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | 070, 0. 105, revascularisation or 0. 175mg/kg/h, respectively, grafting up to 7 days 0. 175mg/kg/h, respectively, double-blind 0. 140 or bailout glycoprotein vs 6. 2% vs 2. 7% 0. 175mg/kg/h IIb/IIIa inhibitor use up to 7 days NCT01076764 / 30-180 days UFH + Composite of all- Underway TIMI major and minor phase III, ept... | 10.18433/j33p49 | review | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | They are not well understood, but seem to be linked with temperature variations in the telescope dome. To circumvent that effect, we considered the SOPHIE HE data of WASP-52 and 60 secured before and after the zero-point change as independent datasets, allowing a free radial-velocity offset to be fitted between them. T... | 10.1051/0004-6361/201220363 | article | en | 2,012 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Andrews, Scotland; -FTS: the 2-m Faulkes Telescope South located at Siding Spring Observatory in New South Wales, Australia; -EulerCam: the new camera at the 1. 2-m Euler-Swiss telescope at La Silla, Chile; -BUSCA: at the Calar Alto Observatory 2. 2-m telescope, Spain; -OverSky: the 0. 36-m telescope at the OverSky Obs... | 10.1051/0004-6361/201220363 | article | en | 2,012 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | The surface gravity log g * was determined from the Ca i lines at 6162 Å and 6439 Å (Bruntt et al. 2010a ), along with the Na i D and Mg i b lines. The spectral types were established from T eff using the table in Gray (2008). The elemental abundances were determined from equivalent width measurements of several clea... | 10.1051/0004-6361/201220363 | article | en | 2,012 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | EulerCam data also show irregularities. We have analyzed the SuperWASP light curve to determine whether they are periodic, and possibly due to the combination of magnetic activity and the rotation of the star. The value of v sin i * derived above together with the estimated stellar radius implies a rotation period of 5... | 10.1051/0004-6361/201220363 | article | en | 2,012 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | (2011). Variability due to star spots is not expected to be coherent on long timescales as a consequence of the finite lifetime of star-spots and differential rotation in the photosphere, and so we analyzed the two seasons of data for WASP-52 separately. The second season of data shows a highly significant periodic mod... | 10.1051/0004-6361/201220363 | article | en | 2,012 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
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