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cc-by | Variables dropped at earlier stages were re-evaluated for inclusion in the final model. Normality of residuals and absence of heteroscedasticity were checked. All tests were two-sided. Statistical analysis was performed using the R package Version 2. 10 [42] and SAS 9. 2 software (SAS Institute, Cary, NC, USA). | 10.1186/s12874-016-0138-y | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Strengths and weaknesses of the study (internal validity) This study is the first to quantify the implementation duration of hospital-based pediatric clinical studies and to identify factors independently related to this duration. A limitation of the study is that the data were collected in 2009, which prevented us fro... | 10.1186/s12874-016-0138-y | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank Céline Feger , Karine Landgren-Hugentobler , and Maya Dorsey for language editing, and the Clinical Trial Units , particularly Dr. Caroline Elie , for helping us to collect the data. This work was supported by a research grant from the Département de la Recherche Clinique et du Développe... | 10.1186/s12874-016-0138-y | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | 78 1 [1;1] 1 Monocentric study 12 (17) 5 (15. 6) 14 (40) 0. 01 4 (80) 1 International study 1 (1) 0 (0) 4 (11) 0. 006 0 (0) 0 Rare disease 50 (69) 20 (63) 27 (77) 0. 43 4 (67) 0 Chronic disease 60 (83) 22 (69) 26 (74) 0. 22 4 (67) 0 Study population 0. 003 0 Pediatric 30 (42) 19 (59) 27 (77) 6 (100) Mixed (children and... | 10.1186/s12874-016-0138-y | article | en | 2,016 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Materials and Methods A retrospective study was carried out on data from a review of the records of 66 patients operated on by the same surgeon, from 2006 to 2014, at the Otorhinolaryngoiatric Unit of the "Centre Hospitalier des Escartons" of Briancon, France, with antrostomy for unilateral maxillary sinusitis and susp... | 10.1155/2016/4169523 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 0%) for 2 days, 9 (36. 0%) for 3 days, 5 (20. 0%) for 4 days, and 4 (16. 0%) for 5 days. There was only one postsurgical complication (4. 0%), an epistaxis on the 5th postsurgical day, which was treated successfully by nasal packing for 48 hours. One other patient had a relapse at one year, treated with Caldwell-Luc ... | 10.1155/2016/4169523 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors thank Sara Tunesi for her statistical advices, Barbara Wade for her linguistic revision, and Davide Mariotto for his digital design support. | 10.1155/2016/4169523 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | GFR measurement and estimation GFR was assessed through a continuous 51 Cr-EDTA (GE Healthcare, Little Chalfont, UK) infusion method. A priming dose of 0. 5 lCi/kg body weight of 51 Cr-EDTA was injected intravenously, followed by a constant 51 Cr-EDTA infusion. After allowing 1 h for equilibration of the tracer in the ... | 10.1111/ajt.13908 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 1 , C and D). mRNA levels of AMPK ␣-, -, and ␥-subunits in liver and skeletal muscle were not different in AMPK␥2 NI and AMPK␥2 RG mice as compared with AMPK␥2 WT mice (data not shown). Taken together, these data demonstrate that the AMPK␥2 NI and AMPK␥2 RG knock-in mutations had no effect on expression of ␥2 subunit ... | 10.1074/jbc.m116.738591 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Slides were digitized using a Nanozoomer 2. 0 HT digital slide scanner (Hamamatsu). Statistical Analyses-All data are shown as the means Ϯ S. E. Statistical significance was calculated by one-way analysis of variance and multiple comparisons. Asterisks denote statistical significance of the AMPK␥2 NI and AMPK␥2 RG grou... | 10.1074/jbc.m116.738591 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments-We acknowledge Dr. Grahame Hardie ( Cell Signaling and Immunology, College of Life Sciences, University of Dundee ) for suggesting that we generate knock-in mice harboring AMPK mutations associated with WPW syndrome, which helped us to understand the causality of WPW syndrome and led to unexpected fin... | 10.1074/jbc.m116.738591 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Data analyses The field data formed a spatial point pattern. We performed exploratory analysis using the Ripley's reduced second moment function K(r) (Ripley, 1981). A test based on 1000 simulations of complete spatial randomness (CSR) was carried out in order to discriminate between random, aggregated and regular poi... | 10.18182/tjf.28744 | article | en | 2,016 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgments We would like to acknowledge support for our work from the Région Centre (project ADRIEN ) and the INRA meta-program SMaCH -Sustainable Management of Crop Health (project SESAME ). We are grateful to A. Roques , C. Robinet , J. Garcia and F. Goussard ( INRA Orléans ) for stimulating discussi... | 10.18182/tjf.28744 | article | en | 2,016 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | In this paper, we assessed precisely the length of incubation period of MERS-CoV infections using two different datasets from Saudi Arabia and from South Korea and showed that the incubation period of MERS-CoV infections appeared to vary depending on the location of the outbreak. | 10.1038/srep35839 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Sources of data. For the outbreak in South Korea, we retrieved publicly available data from multiple sources, including the Korea Center for Disease Control and Prevention, the Korean Ministry of Health and Welfare, the World Health Organization, and local Korean news reports to compile a line list of all confirmed cas... | 10.1038/srep35839 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements This research was supported by the Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences (grant no. U54 GM088558 ), and a commissioned grant from the Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Adm... | 10.1038/srep35839 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Mycobacterium abscessus multiplies similarly inside wild-type and cystic fibrosis conductance transmembrane regulator defective Mf We next evaluated the intracellular growth of both variants in murine and human Mf by infecting cells at an MOI of 1 for 3 h (see Experimental procedures). That M. abscessus S and R survive... | 10.1098/rsob.160185 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Subsequently, cells were fixed with 2% paraformaldehyde (Delta microscopy) for 10 min, permeabilized with 0. 1% Triton X100/PBS for 5 min and blocked with 4% BSA (Euromedex, France), 2% goat serum (Sigma, USA) in PBS for 1 h. Cells were incubated with rabbit anti-LC3 (MBL, France) overnight in blocking buffer, washed a... | 10.1098/rsob.160185 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Cells were washed directly before performing fluorescence imaging. Measurement of the ratio of 450 nm (blue)/ 535 nm (green) fluorescence allowed determining whether the bacteria established a phagosome-cytosol communication. Reading was performed by a fluorescence microscope with AutoPlay (Nikon) for the automatic acq... | 10.1098/rsob.160185 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analyses Fisher's exact test and the Student's t-test were used for all comparisons (GraphPad PRISM version 6. 0d; GraphPad Software, Inc). A p-value less than 0. 05 was considered significant (n. s. ¼ non-significant, *p , 0. 05; **p , 0. 01; ***p , 0. 001; ****p , 0. 0001). | 10.1098/rsob.160185 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | A. -L. R. , A. V. , A. B. , R. S. , A. B. , L. L. , T. D. , L. M. , M. R. and F. G. -M. carried out the microbiology, bacterial-cells interaction, confocal microscopy, electronic microscopy (A. V. with C. d. C. ). J. -L. H. , L. K. , C. d. C. , I. V. , R. B. , L. M. and J. -L. G. participated in the design of the study... | 10.1098/rsob.160185 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements. We greatly acknowledge Dr S. Canaan for critical reading of the manuscript and help in formatting the TIFF files of EM figures and V. Dubois for formatting the figures. We wish to acknowledge TRI-Genotoul Imaging facility (Toulouse, France ). The authors wish to thank Jean Paul Chauvin , head of... | 10.1098/rsob.160185 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Functional maps of BOLD signal were computed using Statistical Parametric Mapping (SPM8, Wellcome Trust Centre for Neuroimaging, University College London, UK) run in MATLAB R2012a (MathWorks, Natick, MA). For first-level single-subject analysis, functional images were preprocessed for slice timing and motion correctio... | 10.1371/journal.pone.0152614 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Cortical Terminations of WM Fascicles Image datasets were co-registered (mutual information algorithm) using iPlan Stereotaxy 3. 0 software. The FA, color-coded direction, and BOLD-cluster maps were co-registered with T1-weighted MR images (anatomical reference). Accuracy of registration was carefully reviewed (visual ... | 10.1371/journal.pone.0152614 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Connections between WM Fascicles and BOLD Clusters Structure-function relationships were investigated by analyzing WM fascicle-BOLD cluster connections at individual level (each subject being its own anatomical reference) within cortical territories known as essential language areas in order to figure out which WM fasc... | 10.1371/journal.pone.0152614 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank Bruno Pereira for his help with statistical analysis and our talented MRI technologists for their engaged involvement in data acquisition. | 10.1371/journal.pone.0152614 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis) methodology was used for the development, the Quality Assurance and the description of the experimental procedures. Conclusion: In an internationally approved quality assurance framework, ML seems promising in predi... | 10.18632/oncotarget.10749 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Research Paper of the PII, but all the patients receiving it are exposed to the potential risk of its acute and late toxicity. Moreover, a study by Crowley et al. supports the use, for selected cases of ACC, of smaller than standard radiation fields, avoiding PII, in order to reduce acute and late toxicity [6] , an at... | 10.18632/oncotarget.10749 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Importance of the considered features By applying the Information gain technique (see Methods section) to the considered dataset of patients, we found that 8 of the considered features carried a significant amount of information for the correct classification of the patients' outcome: PS, T and N stage, uTNM, Stage of ... | 10.18632/oncotarget.10749 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Literature sources and search In August 2015 we searched MEDLINE, PEDro, OSTMED. DR, and the Cochrane Library databases and as well as Google Scholar, the Journal of American Osteopathy Association (JAOA) and the International Journal of Osteopathic Medicine (IJOM) websites. The search strategy was as follows: • for re... | 10.1371/journal.pone.0167823 | review | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Study selection For inclusion in our review, studies had to meet the aforementioned eligibility criteria. For study selection, we considered all techniques claimed by the authors to belong to the field of cranial osteopathy or mentioned in the classical osteopathic literature. If in doubt, we considered the technique t... | 10.1371/journal.pone.0167823 | review | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Data extraction The data extracted included: study design (including randomization and blinding procedures), sample size and characteristics (such as age and/or disease or inclusion criteria), main outcomes and results obtained. For reliability studies we added information regarding examiners (e. g. , number, qualifica... | 10.1371/journal.pone.0167823 | review | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The second study rated as having low risk of bias, by Haller et al. [44] aimed at investigating craniosacral therapy (CST) compared to sham treatment in patients with chronic non-specific neck pain. The primary outcome was pain intensity assessed with visual analog scale and 16 secondary outcomes were investigated. Da... | 10.1371/journal.pone.0167823 | review | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments We thank Dr. Alison Foote from the "Publication in English" service of Grenoble-Alpes University Hospital for critically editing the manuscript. | 10.1371/journal.pone.0167823 | review | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | | DISCUSSION This study addresses the prevalence of self-reported TBI in a population of female prisoners in a French prison. Secondary aims included studying covariables known to be associated with TBI. The main findings were that the rate of self-reported history of TBI was high, with an overall prevalence of 21%, an... | 10.1002/brb3.535 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | | Limitations Our study is cross-sectional and as data were collected by means of an interview (self-report), the results should be interpreted with caution. As, however, the reliability of prisoners' responses is frequently challenged, it is interesting that a recent study involving 200 Australian prisoners highlighte... | 10.1002/brb3.535 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ACKNOWLEDGMENTS The authors wish to express their gratitude to Prof. H Williams for his contribution to the creation of the questionnaire. We would like to thank Dr R. Katz and Mr. James Moore for having scrutinized the manuscript and Mme G. Bard for collecting the data, collating references, and formatting the... | 10.1002/brb3.535 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | FUNDING INFORMATION This study was funded by the "Fondation des Gueules Cassées " and has been supported by the "Centre Ressources du Traumatisme Crânien Ile de France " and Sorbonne Univ Paris 06 , UMR 7371 , UMR S 1146 , Laboratoire d'Imagerie Biomédicale, F-75005, Paris, France. | 10.1002/brb3.535 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Image acquisition was performed under the Zeiss ZEN 2012 software and image processing was carried under the open-source FIJI and ICY software. | 10.1364/boe.7.002362 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Spectral imaging GL261 murine glioma cells expressing DsRed2 (plasmid: pDsRed2-N1, Clontech,Mountain View, USA) were cultured as previously described [11, 16] on glass-bottom Petri dishes. Five microliters of a QD655 solution (QTracker 655, Molecular Probes; 8µl in 50 μl of PBS qsp) were added and images were acquire... | 10.1364/boe.7.002362 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Importantly, our results on the excitation of QD655 and EYFP outline that the 2P excitation spectrum cannot be simply predicted from the monophoton excitation spectrum of the fluorophores. Several similar examples for QD, proteins and organic dyes can be found in online spectra database (http://www. spectra. arizona. e... | 10.1364/boe.7.002362 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments The authors would like to acknowledge Celine Caravagna for contributing to surgical procedures and Gwenaelle Tardif for genotyping and cell culture. This work was supported by grants from Fondation de la Recherche Médicale ( ING20140129149 ) and from Agence Nationale de la Recherche ( ANR15-CE16... | 10.1364/boe.7.002362 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Immunohistochemistry For Six1 immunostaining, SOL and gastrocnemius plantaris (GP) muscles were embedded in cryomatrix and quickly frozen in isopentane cooled with liquid nitrogen. Cryostat sections (10 μm) were fixed in 4 % PFA and washed in 1× PBS. The sections were treated with Antigen Unmasking Solution (H-3300, Ve... | 10.1186/s13395-016-0102-x | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | SDH/GPDH staining Fresh-frozen sections were incubated in 0. 2 M phosphate buffer (pH 7. 6) containing sodium succinate and nitroblue tetrazolium, NBT (N6876, Sigma Aldrich) for 30 min at 37 °C. Sections were then washed with water and mounted in glycerine gelatin medium. GPDH staining was performed by incubation of un... | 10.1186/s13395-016-0102-x | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | ChIP experiments GP and tibialis anterior (TA) muscles of 2 months old female mice were minced with scissors immediately after harvesting and fixed in 1 % formaldehyde for 10 min. Formaldehyde was quenched by addition of 0. 125 M glycine, and muscles were washed twice in PBS. Muscles were then incubated on ice in lysis... | 10.1186/s13395-016-0102-x | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The scanned images were then analyzed with Expression Console software (Affymetrix) to obtain raw data (cel files) and metrics for quality controls. The analysis of some of these metrics and the study of the distribution of raw data show no outlier experiment. RMA normalization was performed using R and normalized data... | 10.1186/s13395-016-0102-x | article | en | 2,016 | true | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Western blot Cell or tissue lysates of GP and SOL from cSix1KO and control mice (20-40 μg) were denatured in Laemmli buffer, separated by SDS-polyacrylamide gel electrophoresis and transferred to nitrocellulose membrane. Membranes were blocked in 50 mM Tris-HCl pH 7. 6, 137 mM NaCl and 0. 1 % (v/v) Tween-20 containing ... | 10.1186/s13395-016-0102-x | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Microarray data accession number Microarray data have been deposited in the Gene Expression Omnibus as accession no. GSE50023. | 10.1186/s13395-016-0102-x | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgements We thank V. Moncollin at ENS Lyon for help with the adult muscle ChIP experiments, the imaging facility at Institute Cochin for technical assistance, the sequencing and genomic platform at Institute Cochin for microarray experiments and F. Dumont and S. Jacques for advice. We Thank Dr. Dan... | 10.1186/s13395-016-0102-x | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Lymph node metastases Negative EUS-FNA of regional lymph nodes and negative staging laparotomy/ hand-assisted-laparoscopy with biopsy of regional lymph nodes Abbreviations: CA 19-9; carbohydrate antigen 19-9, EUS-FNA; Endoscopic ultrasonography-fine needle aspiration. doi:10. 1371/journal. pone. 0156127. t001 was extra... | 10.1371/journal.pone.0156127 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistics Statistical analyses were carried out using IBM SPSS Statistics, (IBM, Armonk, New York, USA). The results are expressed as the means ±SD. Comparison of means was performed with the Student t-test for independent samples. Comparison of categorical variables was performed with the Chi-Square test and Fisher's... | 10.1371/journal.pone.0156127 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Results and Discussion Twenty-one centers uploaded data of 173 patients in the electronic database, resulting in a response rate of 69%. All patients were transplanted between 1990 and 2010. Twenty-six patients were excluded from the database, 12 because they were erroneously coded in the ELTR (the indication for trans... | 10.1371/journal.pone.0156127 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | We determined the use of mTOR inhibitors in postoperative immunosuppressive regimens because of their potential anticancer effect. mTOR inhibitors were used in 11% of cases in group A versus 13% in group B (P = 0. 77). Data on the presence of PSC was available for 25 patients in group A: six patients (24%) had underlyi... | 10.1371/journal.pone.0156127 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments Professor René Adam is custodian of the European Liver Transplant Registry (ELTR). Dr. William F. Bennet is an ELTR Board member. We are much obliged to the following collaborators of this study: • Dr. Frank Lehner and Professor Jurgen Klempnauer from the department of Visceral and Transplant Surgery, H... | 10.1371/journal.pone.0156127 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments Professor René Adam is custodian of the European Liver Transplant Registry (ELTR). Dr. William F. Bennet is an ELTR Board member. We are much obliged to the following collaborators of this study: • Dr. Frank Lehner and Professor Jurgen Klempnauer from the department of Visceral and Transplant Surgery, H... | 10.1371/journal.pone.0156127 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Then, libraries were constructed and captured by using SureSelect Human All Exon v5 kit (Agilent), following the manufacturer's protocol. Paired-end (2 × 151 bases) sequencing was performed on a NextSeq500 device (Illumina). Obtained sequences were aligned and annotated with the human Hg19 genome based on the SureSelec... | 10.3748/wjg.v22.i48.10680 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | It was interesting to see that among the 8 altered genes (Table 1 ), we observed a SMAD4 stop mutation, which is frequently found in CRC. An activating mutation of AKT1 was observed (Q79K). It could be targetable by protein kinase B (AKT)/mTor inhibitors. Surprisingly, we observed a constitutive Chek2 mutation (R117G)... | 10.3748/wjg.v22.i48.10680 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | METHODS Electronic databases were systematically searched for original articles referring to the use of systemic mTOR inhibitors in vascular anomalies. PRISMA guidelines were followed for the systematic review. | 10.2340/00015555-2300 | review | en | 2,015 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Search strategy The search was performed by one author (MN) with the assistance of an information specialist (OL). Electronic databases MEDLINE via PubMed, CENTRAL, LILACS and EMBASE were searched on 12 November 2014, with no limitations on dates or language. To search for studies of mTOR inhibitors, the following keyw... | 10.2340/00015555-2300 | review | en | 2,015 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data extraction For each selected report, 2 authors (MN, AM) independently extracted information on the first author, publication year, journal, country/site, study design, characteristics of patients, type of vascular anomaly, number of lesions, associated complications, type of mTOR inhibitor, efficacy and side-effec... | 10.2340/00015555-2300 | review | en | 2,015 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Main results The aim of this systematic review was to assess the efficacy and safety of mTOR inhibitors for vascular anomalies in children and adults. Data were assessed for 84 patients; all children < 18 years. Sirolimus was the most frequent mTOR inhibitor used and was rapidly efficient in all cases, at a median of 2... | 10.2340/00015555-2300 | review | en | 2,015 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ACKNOWLEDGEMENTS The authors would like to thank Patricia Casanova and Olivier Lauze for their technical assistance. The authors declare no conflicts of interest. | 10.2340/00015555-2300 | review | en | 2,015 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Tissue preparation for organ bath studies Bronchial rings were suspended horizontally on tissue hooks in an organ bath containing 5 ml of PSS (gassed with 95% O 2 , 5% CO 2 ) and maintained at 37 °C (pH 7. 40). Each preparation was connected to a force displacement transducer (it1, Emka Technologies, Paris, France). Is... | 10.1186/s12931-016-0464-y | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Drugs ACh, indomethacin, L-NAME, tetrodotoxin, Gd 3+ , nicardipine, capsazepine, and calphostin C were purchased from Sigma-Aldrich (St. Louis, MO, USA), tertiapin was bought from Bachem (Voisin le Bretonneux, France), 4 ), bronchial tone at rest immediately after the end of cyclic stretching; (5), post-stretching br... | 10.1186/s12931-016-0464-y | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The results were analyzed using Student's t test for paired and normally distributed data or using a Wilcoxon matched-pairs signed rank test if the data were not normally distributed. The standardized effect size |d| for the difference between the means was calculated in order to determine whether the observed effect o... | 10.1186/s12931-016-0464-y | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Availability of data and material The datasets supporting the conclusions of this article are available to the corresponding author. | 10.1186/s12931-016-0464-y | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Three-dimensional spheroid cell culture MiaPaCa-2 cells (5×10 3 /well) were seeded in 96-well plates containing Matrigel (Corning). The culture medium (containing appropriate concentration of Met or Mito-Met 10 ) was replaced every two days. At days 3, 7, and 14 the images were acquired using a Nikon Eclipse Ti inverte... | 10.1158/0008-5472.can-15-2534 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Cytotoxicity assay To determine the cytotoxicity of Mito-Met analogs and other TPP + -conjugated compounds, we used the Sytox Green-based assay as described previously (16). MiaPaCa-2 cells were treated for 24 h, and dead cells were monitored in real time in the presence of 200 nM Sytox Green (Invitrogen) under an atm... | 10.1158/0008-5472.can-15-2534 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Cell cycle analysis PANC1 cells (5×10 5 ) were seeded into 35 mm dishes and immediately treated with 10 mM Met or 10 μM Mito-Met 10 in complete media. At 48 h post-treatment, cells were fixed with 70% ethanol, permeabilized with 0. 25% Triton X-100 in PBS, and stained using a propidium iodide/RNase solution (20 μg/ml a... | 10.1158/0008-5472.can-15-2534 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Over time, PDAC tumor bearing mice treated with Mito-Met 10 had lower tumor burden when assessed at early, middle, and later time points as visualized by bioluminescent imaging, with smaller tumors at the completion of the study (Fig. 6D ). Serum from these animals was collected, and hepatic and kidney toxicity tested ... | 10.1158/0008-5472.can-15-2534 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments Financial support: This work was supported by grants from the NIH National Cancer Institute [ U01 CA178960 (to M. B. Dwinell and B. Kalyanaraman ) and R01 CA152810 (to B. Kalyanaraman)], the Medical College of Wisconsin Cancer Center (to M. B. Dwinell , B. Kalyanaraman and B. Johnson ) and... | 10.1158/0008-5472.can-15-2534 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Infarct size measurement In regional IR experiments, at the end of reperfusion, the coronary artery was reoccluded. Evans blue dye (2%) was then injected through the cannulated aorta to delineate the area at risk (AR), which remained unstained by the Evans blue solution. The heart was removed and the left ventricle (LV... | 10.1371/journal.pone.0162632 | article | en | 2,016 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | After washing, bound antibody was visualized by use of horseradish peroxidase-conjugated goat anti-rabbit or anti-sheep antibody (1:5000, Cell Signalling, Saint Quentin, Yvelines, France) for 1 hour at room temperature. Loading and quality transfer were evaluated by tubulin staining (1:1000, Santa cruz, La Jolla, CA, U... | 10.1371/journal.pone.0162632 | article | en | 2,016 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments We wish to thank Dr C. Arnaud ( Laboratoire HP2, INSERM, Grenoble, France ), Pr C. Batandier ( Laboratoire de Bioénergetique Fondamentale Appliquée, Grenoble, France ) and Pr R. Clapier-Ventura ( Laboratoire de Signalisation et Physiopathologie Cardiovasculaire, UMR-S 1180, Paris, France ) for tec... | 10.1371/journal.pone.0162632 | article | en | 2,016 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The first objective was to track the labeled cells. To this end, a cryogenic probe (Cryoprobe TM , Bruker) was used for high resolution. The second objective was to evaluate the fistula healing by measuring the fistula orifice with the software, Paravision 5. 1, JIVE tool (Bruker), in the three orthogonal planes (Figur... | 10.7150/thno.14064 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The density of the microvascular network at the transplantation site and its periphery was also investigated by pCLE after the intravenous administration of FITC-dextran 70 kDa. Mosaicing TM software (Mauna Kea Technologies, France) was employed to enable a real-time display of the draft mosaic gathering the acquired a... | 10.7150/thno.14064 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | All slides were digitally scanned (Digitiser Hamamatsu Photo-nics®, Massy, France) and analyzed with dedicated software ((NDP. view software®, Massy, France). | 10.7150/thno.14064 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistics The results are presented as means ± standard deviation for continuous variables, and as percentages for categorical variables. GraphPadPrism (Graphpad Software, La Jolla, CA, USA) software was used for statistical analyses. Fischer's exact test was carried out for comparisons between categorical variables a... | 10.7150/thno.14064 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments This work was supported by ENCITE , co-funded by the European Commission under the 7 th Framework Programme. We sincerely thank Sophie Camilleri-Broet ( Department of Pathology, Hôpital Européen Georges Pompidou, Paris, France ) for her assistance in the field of histology; Josette Legagneux ( Mi... | 10.7150/thno.14064 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Literature search We performed a systematic search on PubMed for articles on breast screening trials. We also searched reference lists in major reviews [17] [18] [19] and in publications on breast screening trials we already had. We retrieved all articles reporting original data of these trials. Three of us (PA, MB, ... | 10.1371/journal.pone.0154113 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Search Strategy We will search the Cochrane Database of Systematic reviews to identify all systematic reviews that included at least 1 RCT involving adult kidney transplant recipients. We will retrieve the full text article of all RCTs included in the systematic review, and also search for all additional articles publi... | 10.1097/txd.0000000000000593 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Types of Studies For feasibility, the Cochrane Database of Systematic reviews will be used as a sampling frame to identify RCTs in kidney transplantation, as has been done in previous analysis of outcomes reporting in RCTs. 22, 50 Based on a preliminary search, we expect that more than 300 RCTs will be included. | 10.1097/txd.0000000000000593 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data Extraction One reviewer (B. S. ) will extract characteristics of all the trials including: first author, date of publication, country/ies in which the trial was conducted, sample size, participant characteristics (range and mean age, time since transplant, sex), trial duration, name and type of intervention (eg, s... | 10.1097/txd.0000000000000593 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data Analysis and Presentation The data will be entered into Microsoft Excel to assist with data management, tabulation, and analysis. Author B. S. will group all similar outcomes into appropriate outcome domains, which will be reviewed and discussed by the SONG-Tx Steering Group (J. R. C. [Chair], K. B. , J. G. , M. A... | 10.1097/txd.0000000000000593 | article | en | 2,016 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Purposive sampling to obtain a maximum variation in the demographics, clinical characteristics (patients), and professional experiences and roles (health professionals), and snowballing strategies (where participants can nominate or extend an invitation to other relevant stakeholder members to participate) will be used... | 10.1097/txd.0000000000000593 | article | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | ACKNOWLEDGMENT The SONG-Tx initiative is endorsed by The Transplantation Society. The authors also want to acknowledge the following organizations for their partnerships and support: Cochrane Kidney and Transplant, Kidney Disease Improving Global Outcomes (KDIGO), PKD International, World Transplant Games Federat... | 10.1097/txd.0000000000000593 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | CMV QNAT was performed once a week for the first 3 mo, once a month between months 3 and 6, and then every 2 months up to 1 year and if CMV disease was suspected clinically. During the virological monitoring of CMV disease, the assay was performed once a week until two consecutive negative CMV DNAemia QNATs occurred. A... | 10.1111/ajt.13781 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Flow cytometry analysis and monitoring of Vd2 neg cd T cells Blood samples were analyzed at the Bordeaux University Hospital immunology laboratory by flow cytometry using a FC500 flow cytometer from Beckman Coulter. All blood samples were withdrawn on EDTA anticoagulant in Vacutainer 5-mL tubes (BD Biosciences, Mountai... | 10.1111/ajt.13781 | article | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank Catherine Rio as a nurse coordinator. We also acknowledge the technicians from the Laboratories of Virology and Immunology in Bordeaux University Hospital and the Centre National de R ef erence des Cytom egalovirus (Limoges) for their significant contribution to this study. | 10.1111/ajt.13781 | article | en | 2,016 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | The GWAS meta-analysis results included three associations in novel loci (rs17603856 (6p23), rs1887428 (9p24) and rs669763 (16q13)) with genome-wide levels of significance (P < 5 × 10 -8 ; Fig. 1b ). In addition, the major histocompatibility complex (MHC) and, to a lesser extent, the IRF5 locus on chromosome 7 showed s... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 01. These included rs17603856 and rs1887428 but not rs669763, which failed quality control. We then genotyped these 18 SNPs in a European replication cohort comprising 1,478 cases and 6,925 controls3. Data from an additional European-American GWAS (1,165 independent cases and 2,107 controls) were also included in this ... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | We then carried out replication using a second European GWAS15 independent of our main European GWAS and de novo genotyping in a new data cohort of European ancestry. | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis Association testing-After imputation, we analyzed each GWAS data set for association (SNPTEST36), fitting an additive model. We used the inverse variance method for metaanalysis, combining data from the three studies for SNPs with an imputation INFO score of >0. 7 in all three studies. Testing for ... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Although this did not identify any additional shared loci (Supplementary Table 1b ), there was suggestive evidence for two loci (P < 0. 05 after multiple testing adjustment within loci but not after adjusting across loci). Consistency of association between ancestries-We tested the hypothesis that the genome-wide asso... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | This removed only 10% of the regions, leaving 2,338 regions. The lowest P value within each window was taken as the strength of association for that particular window. Each P value within each region was adjusted for multiple testing using a Bonferroni adjustment, to avoid bias in ranking agreement owing to the lowest ... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Testing for independent effects within loci-We tested for independent effects of the two SNPs (rs17321999 and rs7579944) within the 2p23. 1 locus by fitting a multiple regression model with both SNPs as explanatory variables (results for each SNP in this analysis are conditional on the other SNP as a covariate). We che... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | SNPs spanning a 1-Mb window were considered as one region, and we selected only independent SNPs within this region, using LD as a measure of independence. We carried out a gene-based test on the meta-analyzed data, using only SNPs with INFO scores > 0. 9, with the software KGG39-41. One SNP from each of the loci that ... | 10.1038/ng.3603 | review | en | 2,016 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Genotyping of replication data Genotyping of 130 SNPs was carried out for the 3,614 cases and 5,924 controls forming the Chinese replication set, using the Sequenom platform. This set of 130 SNPs included 105 SNPs in loci not previously reported as associated with SLE and 25 SNPs in loci that had previously been publis... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | SNPs were removed if HWE P < 1. 00 × 10 -4. After QC, the Chinese replication consisted of 3,043 cases and 5,074 controls with genotyping on 64 SNPs. The European replication data comprised 1,478 cases and 6,925 controls genotyped for 18 SNPs with an FDR of 1% in the Chinese replication study. The cases were of Europea... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Gene expression data Gene expression data came from two sources. We obtained data from Fairfax et al. 17 and unpublished data from B. Fairfax and J. Knight for NK cells, naive monocytes, monocytes stimulated by lipopolysaccharide (harvested after 2 h and 24 h), monocytes stimulated by interferon, and B cells. We obtain... | 10.1038/ng.3603 | review | en | 2,016 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
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