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ART002000342
|
oai_dc
|
Wilson’s Disease in Bangladeshi Children: Analysis of 100 Cases
|
Wilson’s Disease in Bangladeshi Children: Analysis of 100 Cases
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Md. Rukunuzzaman(Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh)"
] |
Purpose: To evaluate clinical and laboratory profile of Wilson’s disease (WD) in children. Methods: This cross sectional study was conducted at Bangabandhu Sheikh Mujib Medical University Hospital. Bangladesh, over a period of 3 years. One hundred consecutive children of WD between 3 to 18 years of age were evaluated.Results: Mean age was 8.5±1.5 years. Male female ratio was 2:1. Ninety-one percent of patients were Muslim and 9% Hindu. A total of 53% cases of hepatic WD presented between 5 to 10 years of age and most of the neurologic WD manifested in 10-15 years age group. Sixty-nine children presented only with hepatic manifestations, 6 only with neurological manifestations, 14 with both hepatic and neurological manifestation, 10 children was asymptomatic and 1 patient presented with psychiatric features. WD presented as chronic liver disease (CLD) in 42%, CLD with portal hypertension in 34%, acute hepatitis in 20% and fulminant hepatic failure in 4% cases. Stigmata of CLD were found in 18% patients. Keiser-Fleischser ring was found in 76% total patients. Elevated serum transaminase was found in 85% cases, prolonged prothrombin time in 59% cases and hypoalbuminaemia in 53% cases. A total of 73% patients had low serum ceruloplasmin, basal urinary copper of ＞100 μg/day was found in 81% cases and urinary copper following penicillamine challenge of ＞1,200 μg/day was found in 92% cases. Conclusion: Majority of studied WD children presented with hepatic manifestation of which 76% presented with CLD. Any child presented with jaundice after the age of 3 years should be investigated for WD.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART002000343
|
oai_dc
|
A Case of Visceral Autonomic Neuropathy Complicated by Guillain-Barre Syndrome Accompanied with Cyclic Vomiting Syndrome-like Disorder in a Child
|
A Case of Visceral Autonomic Neuropathy Complicated by Guillain-Barre Syndrome Accompanied with Cyclic Vomiting Syndrome-like Disorder in a Child
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Suk Jin Hong(Catholic University of Daegu); 최병호(경북대학교)"
] |
We present a case of an 8-year-old boy with visceral autonomic neuropathy complicated by Guillain-Barre syndrome. In this pediatric patient, gastroparesis was the major symptom among the autonomic symptoms. Due to the gastro-paresis, there was no progress with the oral diet, and nutrition was therefore supplied through a nasojejunal tube and gastrojejunal tube via Percutaneous endoscopic gastrostomy (PEG). After tube feeding for 9 months, the pa-tient’s gastrointestinal symptoms improved and his oral ingestion increased. The pediatric patient was maintained well without gastrointestinal symptoms for 3 months after removal of the PEG, had repeated vomiting episodes which lead to the suspicion of cyclic vomiting syndrome. Then he started treatment with low-dose amitriptyline, which re-sulted in improvement. Currently, the patient has been maintained well for 6 months without recurrence, and his present growth status is normal.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART002000344
|
oai_dc
|
A Case of Intussusception with Acute Appendicitis
|
A Case of Intussusception with Acute Appendicitis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Hyung Min Kee(Chung-Ang University); Ji Young Park(Chung-Ang University); 이대용(중앙대학교); 임인석(중앙대학교)"
] |
In children presenting to hospital with gastrointestinal symptoms, diseases such as intussusception and acute appen-dicitis require particular attention and careful examination. Early diagnosis and proper treatment are important be-cause of possible severe complications such as peritonitis and death. Intussusception and appendicitis share similar clinical manifestations. More importantly, the presence of acute appendicitis together with intussusception in children is very rare. We describe an interesting case of a 38-month-old boy who presented with abdominal pain in the right lower quadrant. His vital signs were stable and laboratory test findings showed no specific alterations. We detected tenderness in the right lower quadrant. A computed tomography scan showed an ileocolic intussusception with no strangulation and diffuse wall thickening of the appendix trapped within the intussusception. The patient underwent an appendectomy and manual reduction.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART002000345
|
oai_dc
|
Clinical, Biochemical, and Genetic Characterization of Glycogen Storage Type IX in a Child with Asymptomatic Hepatomegaly
|
Clinical, Biochemical, and Genetic Characterization of Glycogen Storage Type IX in a Child with Asymptomatic Hepatomegaly
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Jung Ah Kim(Asan Medical Center Children’s Hospital); Ja Hye Kim(Asan Medical Center Children’s Hospital); Beom Hee Lee(Asan Medical Center Children’s Hospital); Gu-Hwan Kim(Asan Medical Center Children’s Hospital); Yoon S. Shin(Molecular Genetics and Metabolism Laboratory,Munich, Germany); Han-Wook Yoo(Asan Medical Center Children’s Hospital); Kyung Mo Kim(Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine)"
] |
Glycogen storage disease type IX (GSD IX) is caused by a defect in phosphorylase b kinase (PhK) that results from mutations in the PHKA2, PHKB, and PHKG2 genes. Patients usually manifest recurrent ketotic hypoglycemia with growth delay, but some may present simple hepatomegaly. Although GSD IX is one of the most common causes of GSDs, its biochemical and genetic diagnosis has been problematic due to its rarity, phenotypic overlap with other types of GSDs, and genetic heterogeneities. In our report, a 22-month-old boy with GSD IX is described. No other manifestations were evident except for hepatomegaly. His growth and development also have been proceeding normally. Diagnosed was made by histologic examination, an enzyme assay, and genetic testing with known c.3210_3212del (p.Arg1070del) mutation in PHKA2 gene.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART002000346
|
oai_dc
|
Atypical β-Catenin Activated Child Hepatocellular Tumor
|
Atypical β-Catenin Activated Child Hepatocellular Tumor
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Aynur Turan(Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey); Havva Akmaz Unlu(Ankara Atatürk Training and Research Hospital, Ankara, Turkey); Esra Karakus(Ankara Atatürk Training and Research Hospital, Ankara, Turkey); Arzu Yazal Erdem(Ankara Atatürk Training and Research Hospital, Ankara, Turkey); Zeynep Ilerisoy Yakut(Ankara Atatürk Training and Research Hospital, Ankara, Turkey)"
] |
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular ad-enomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been pre-viously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841291
|
oai_dc
|
Urosodeoxycholic Acid Therapy in a Child with Trimethoprim- Sulfamethoxazole-induced Vanishing Bile Duct Syndrome
|
Urosodeoxycholic Acid Therapy in a Child with Trimethoprim- Sulfamethoxazole-induced Vanishing Bile Duct Syndrome
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"조현정(충남대학병원); 좌혜정(충남대학병원); 김규선(충남대학병원); 강대용(충남대학병원); 김재영(충남대학교)"
] |
We present a case of a 7-year-old boy who had cholestasis after trimethoprim-sulfamethoxazole combination therapy. Liver biopsy was performed 36 days after the onset of jaundice because of no evidence of improving cholestasis. Liver histology revealed portal inflammation, bile plug, and biliary stasis around the central vein with the loss of the interlobular bile ducts. Immunohistochemical stains for cytokeratin 7 and 19 were negative. These findings were consistent with those of vanishing bile duct syndrome (VBDS). Chlestasis was progressively improved with dose increment of urosodeoxycholic acid from conventional to high dose. This is the first case report of trimetho-prime-sulfamethoxazole associated VBDS in Korean children. The case suggests that differential diagnosis of VBDS should be considered in case of progressive cholestatic hepatitis with elevation of alkaline phosphatase and gam-ma-glutamyl transpeptidase after or during taking medicine to treat nonhepatobiliary diseases illness.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841237
|
oai_dc
|
Abnormality on Liver Function Test
|
Abnormality on Liver Function Test
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"강기수(제주대학교)"
] |
Children with abnormal liver function can often be seen in outpatient clinics or inpatients wards. Most of them have respiratory disease, or gastroenteritis by virus infection, accompanying fever. Occasionally, hepatitis by the viruses causing systemic infection may occur, and screening tests are required. In patients with jaundice, the tests for differ-ential diagnosis and appropriate treatment are important. In the case of a child with hepatitis B virus infection vertically from a hepatitis B surface antigen positive mother, the importance of the recognition of immune clearance can’t be overstressed, for the decision of time to begin treatment. Early diagnosis changes the fate of a child with Wilson disease. So, screening test for the disease should not be omitted. Non-alcoholic fatty liver disease, which is mainly discovered in obese children, is a new strong candidate triggering abnormal liver function. Muscular dystrophy is a representative disease mimicking liver dysfunction. Although muscular dystrophy is a progressive disorder, and early diagnosis can’t change the fate of patients, it will be better to avoid parent’s blame for delayed diagnosis.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841233
|
oai_dc
|
Long Term Outcomes after Pediatric Liver Transplantation
|
Long Term Outcomes after Pediatric Liver Transplantation
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Nada A. Yazigi(Georgetown University Hospital)"
] |
Long term outcomes after liver transplantation are major determinants of quality of life and of the value of this heroic treatment. As short term outcomes are excellent, our community is turning to take a harder look at long term outcomes. The purpose of this paper is to review these outcomes, and highlight proposed treatments, as well as pressing topics needing to be studied. A systemic review of the English literature was carried in PubMed, covering all papers address-ing long term outcomes in pediatric liver transplant from 2000-2013. Late outcomes after pediatric liver transplant affect the liver graft in the form of chronic liver dysfunction. The causes include rejection particularly humoral rejection, but also de novo autoimmune hepatitis, and recurrent disease. The metabolic syndrome is a major factor in long term cardiovascular complication risk. Secondary infections, kidney dysfunction and malignancy remain a reality of those patients. There is growing evidence of late cognitive and executive function delays affecting daily life pro-ductivity as well as likely adherence. Finally, despite a good health status, quality of life measures are comparable to those of children with chronic diseases. Long term outcomes are the new frontier in pediatric liver transplantation. Much is needed to improve graft survival, but also to avoid systemic morbidities from long term immunosuppression. Quality of life is a new inclusive measure that will require interventions and innovative approaches respectful not only on the patients but also of their social circle.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841270
|
oai_dc
|
Subclinical Vitamin D Insufficiency in Korean School-aged Children
|
Subclinical Vitamin D Insufficiency in Korean School-aged Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"한상우(을지병원 소아청소년과); 강하라(을지병원 소아청소년과); 김한겸(을지대학교 의학과); 김주현(을지병원 소아청소년과); 엄지현(을지병원 소아청소년과); 서지영(을지대학교)"
] |
Purpose: Recently, vitamin D insufficiency has increased and has been correlated to growth and puberty in children. This study was conducted to find the prevalence of subclinical vitamin D insufficiency and its influence on school-aged children in Korea.Methods: The subjects of this study were 397 children aged 7 to 15 years who had been tested for 25-OH vitamin D3 among the outpatients of the Department of Pediatrics in Eulji General Hospital from March 2007 to February 2011. Data for age, sex, comorbidities, serum 25-OH vitamin D3, height, weight, body mass index (BMI), and sunlight exposure time were collected before and after 3 months of vitamin D administration, retrospectively.Results: Vitamin D insufficiency was present in 343 (86%) of the subjects. In the vitamin D insufficient group, chrono-logical age was 8.96±1.72 years, mean height (z-score [z]) was 0.51±1.26, mean BMI (z) was 0.81±2.20, and bone age was 10.26±1.75 years. In the vitamin D sufficient group, chronological age was 9.61±1.77 years, mean height (z) was −0.66±0.98, mean BMI (z) was −0.01±1.16, and bone age was 9.44±2.12 years. A paired t-test showed that three months after vitamin D administration, the mean 25-OH vitamin D3 level in the insufficient group increased to 24.38 ±10.03 ng/mL and mean BMI (z) decreased to 0.67±1.06. Conclusion: In Korean school-aged children, vitamin D insufficiency were relatively higher and may be closely related with higher BMI. Insufficient rise of the level of vitamin D after supplementation suggest the new supplementation guidelines, especially for Korean children.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841235
|
oai_dc
|
Acute Abdominal Pain in Children
|
Acute Abdominal Pain in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김준성(울산대학교)"
] |
Acute abdominal pain is a common complaint in childhood, and it can be caused by a wide range of underlying surgical and non-surgical conditions. The most common non-surgical condition is gastroenteritis, while the most common surgical condition is appendicitis. Abdominal pain in children varies with age, associated symptoms, and pain location. Although acute abdominal pain is usually benign and self-limiting, there are uncommon but life-threatening conditions that require urgent care. Meticulous history taking and physical examinations are essential to determine the cause of acute abdominal pain and to identify children with surgical conditions such as appendicitis.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841253
|
oai_dc
|
Regurgitation and Gastroesophageal Reflux Disease in Six to Nine Months Old Indonesian Infants
|
Regurgitation and Gastroesophageal Reflux Disease in Six to Nine Months Old Indonesian Infants
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Badriul Hegar(University of Indonesia); Debora Hindra I. Satari(University of Indonesia); Damayanti R. Sjarif (University of Indonesia); Yvan Vandenplas(Vrije Universiteit Brussel)"
] |
Purpose: Regurgitation is known to peak at the age of 3-4 months, with a sharp decrease around the age of 6 months. Little is known about the natural evolution of infants who still regurgitate after the age of 6 months.
Methods: Hundred thirty-one infants older than 6 months regurgitating more than once a day were followed for a period of 3 months. Results: According to our data, gastroesophageal reflux disease (GERD) is seldom at this age. Most of the infants regurgitated 3 or more times/day and spit up an estimated volume of more than 15 mL. Eighty-five parents were educated regarding frequency of feeding. There were only 6 infants that still had frequent regurgitation (＞3 times/day) despite an appropriate feeding schedule. The Infant GER Questionnaire score reached a score of 0 in 50% of the infants after one month of follow-up and in 81.9% at the third month of follow-up. There was an increase of the “weightfor age z-score” trends in infants that still regurgitated at the end of follow-up and a declining z-score in infants that no longer regurgitated. An explanation may be that infants that regurgitate drink larger volumes than infants who do not regurgitate. Conservative treatment (reassurance, dietary treatment, behavioral advice) resulted in a sig-nificant better outcome than natural evolution. Conclusion: Regurgitation that persisted after the age of 6 months, strongly decreased during a 3-month follow-up with conservative treatment. GERD is rare in this age group; therefore, anti-reflux medication is only seldom needed.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841242
|
oai_dc
|
Poisoning in Korean Children and Adolescents
|
Poisoning in Korean Children and Adolescents
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"우재혁(가천의과대학교); 류일(가천대학교)"
] |
Drug intoxication in children and adolescents is not uncommon in Korea. But the tendency of intoxication is changing with some factors, such as national surveillance system, Naderism and increasing concern among physicians. But the death rate of intoxication among adolescents is increasing in spite of decreasing total death rate of intoxication among children and adolescents. Therefore the physician must be concerned about the basic management of in-toxication and figure out the common toxic substance among children and adolescents.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841261
|
oai_dc
|
Experiences with Endoscopic Interventions for Variceal Bleeding in Children with Portal Hypertension: A Single Center Study
|
Experiences with Endoscopic Interventions for Variceal Bleeding in Children with Portal Hypertension: A Single Center Study
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김승진(울산대학교 의학과); 오석희(울산대학교 의학과); 조진민(울산대학교 의학과); 김경모(울산대학교)"
] |
Purpose: The aim of this study was to compare the efficacy and safety of band ligation and injection sclerotherapy in the endoscopic treatment of children with variceal bleeding.Methods: The study population included 55 children, all of whom were treated at the time of endoscopic diagnosis of esophageal varices at Asan Medical Center, Seoul, Korea, between January 1994 and January 2011. The primary outcomes included initial success rates and duration of hemostasis after endoscopic management (band ligation vs. injectionsclerotherapy).Results: The mean age was 6.7±5.2 years and the mean follow-up time was 5.4±3.7 years. The most common cause of esophageal varices was biliary atresia. Of 55 children with acute variceal bleeding, 39 had band ligation and 16 had injection sclerotherapy. No differences between groups were observed in terms of the size, location, and pres-ence of red color sign. The success rates of band ligation and sclerotherapy in the control of acute bleeding episodes were 89.7% and 87.5%. The mean duration of hemostasis after endoscopic intervention was 13.2±25.1 months. After one year, 19 of 39 patients (48.7%) treated with band ligation and 7 of 16 patients (43.8%) with injection scle-rotherapy had experienced rebleeding episodes. Complications after the procedures were observed in 10.3% and 18.8% of children treated with band ligation and injection sclerotherapy.Conclusion: The results of our current study suggest that band ligation and injection sclerotherapy are equally efficient treatments for the control of acute variceal bleeding and prevention of rebleeding.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841281
|
oai_dc
|
Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic
|
Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"유석동(부산대학교); 황은하(부산대학교); 이연주(부산대학교); 박재홍(부산대학교)"
] |
Purpose: To investigate the clinical characteristics and outcomes among infants and toddlers with failure to thrive (FTT).Methods: This retrospective study was done with 123 patients who had visited Pusan National University Children’sHospital during their first two years of life and had received an FTT diagnosis. We compared the clinical characteristics of the patients based on the causes of their FTT and their ages at the time of first hospital visit. We investigated triggering factors, feeding practices, and outcomes in 25 patients with nonorganic FTT (NOFTT).Results: Eighty cases (65.0%) were NOFTT. The gestational ages, birth weights, and weights at the first visits were significantly lower in patients with organic FTT (OFTT) (p＜0.05). Infants who had first visited the clinic at age ＜6 months had the least z-score. The percentage of patients with severe weight decline was higher in OFTT than in NOFTT (60.0% vs. 17.3%). The z-scores at the follow-up visits were improved after treatment in both of the groups. Preceding infection was the most common triggering factor of NOFTT and persecutory feeding as abnormal behavior of caregiver was observed in 22 cases (88.0%). After treatment with feeding method modification, all patients with NOFTT showed normal growth. Conclusion: Weight decline is more severe in OFTT patients and in younger patients at the first visit. Infants with FTT can attain normal weight gain growth by treating organic diseases and supplying proper nutrition in OFTT, and by correct-ing abnormal dietary behavior of caregiver in NOFTT.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001841284
|
oai_dc
|
Association between Celiac Disease and Intussusceptions in Children: Two Case Reports and Literature Review
|
Association between Celiac Disease and Intussusceptions in Children: Two Case Reports and Literature Review
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Shahsanam Gheibi(Urmia University of Medical)"
] |
Association between celiac disease and intussusception has been reported in adult. Although intussusception is com-mon in children, it rarely has been reported in association with celiac disease. Two children, 5 and 7 years old, with celiac disease are reported here, whose initial presentation was intussusception prior to investigation for concomitant failure to thrive. They presented with acute and severe abdominal distention with vomiting, and donuts and pseu-do-kidney appearance in abdominal ultrasonography. One patient’s intussusception had reducted spontaneously, however the other had required surgery. In investigation for concomitant failure to thrive, tissue transglutaminase levels were very high and duodenal biopsies revealed celiac disease. Thus celiac testing is recommended in children with intussusception and growth failure.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865422
|
oai_dc
|
Treatment of Cow’s Milk Protein Allergy
|
Treatment of Cow’s Milk Protein Allergy
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Yvan Vandenplas(Universitair Kinderziekenhuis Brussel, Vrije Universiteit Brussel); Elisabeth De Greef(Universitair Kinderziekenhuis Brussel, Vrije Universiteit Brussel); Thierry Devreker(Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel)"
] |
The diagnosis and treatment of cow’s milk protein allergy (CMPA) is still a challenge. A systematic literature search was performed using Embase, Medline, The Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Clinical Trials for the diagnosis and treatment of cow’s milk allergy (CMA). Since none of the symptoms of CMPA is specific and since there is no sensitive diagnostic test (except a challenge test), the diagnosis of CMPA remains difficult. A “symptom-based score” is useful in children with symptoms involving different organ systems. The recommended dietary treatment is an extensive cow milk based hydrolysate. Amino acid based formula is recommended in the most severe cases. However, soy infant formula and hydrolysates from other protein sources (rice) are gaining popularity, as they taste better and are cheaper than the extensive cow’s milk based hydrolysates. Recent meta-analyses confirmed the safety of soy and estimate that not more than 10-15% of CMPA-infants become allergic to soy. An accurate diagnosis of CMA is still difficult. The revival of soy and the development of rice hydro-lysates challenge the extensive cow’s milk based extensive hydrolysates as first option and amino acid formula.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865423
|
oai_dc
|
Sedation for Pediatric Endoscopy
|
Sedation for Pediatric Endoscopy
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이명철(메리놀병원)"
] |
It is more difficult to achieve cooperation when conducting endoscopy in pediatric patients than adults. As a result, the sedation for a comfortable procedure is more important in pediatric patients. The sedation, however, often in-volves risks and side effects, and their prediction and prevention should be sought in advance. Physicians should familiarize themselves to the relevant guidelines in order to make appropriate decisions and actions regarding the preparation of the sedation, patient monitoring during endoscopy, patient recovery, and hospital discharge. Furthermore, they have to understand the characteristics of the pediatric patients and different types of endoscopy. The purpose of this article is to discuss the details of sedation in pediatric endoscopy.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865424
|
oai_dc
|
Esophageal pH and Combined Impedance-pH Monitoring in Children
|
Esophageal pH and Combined Impedance-pH Monitoring in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"신명석(가톨릭대학교)"
] |
Esophageal pH monitoring is considered the gold standard for the diagnosis of gastroesophageal reflux disease because of the normal ranges across the pediatric age range. However, this method can only detect acid reflux. Multichannel intraluminal impedance-pH (MII-pH) monitoring has recently been used for the detection of bolus reflux in infants and children. This method allows for the detection of liquid, gas or mixed reflux in addition to acid, weakly acidic or weakly alkaline reflux. MII-pH monitoring can record the direction of flow and the height of reflux, which are useful parameters to identify an association between symptoms and reflux. However, the technique is limited by its high cost and the lack of normative data of MII-pH in the pediatric population. Despite certain limitations, MII-pH monitoring will become more common and gradually replace pH monitoring in the future, because pH monitoring is part of MII-pH.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865425
|
oai_dc
|
Clinical Applications of Gastrointestinal Manometry in Children
|
Clinical Applications of Gastrointestinal Manometry in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"홍지나(강원대학교)"
] |
Manometry is a noninvasive diagnostic tool for identifying motility dysfunction of the gastrointestinal tract. Despite the great technical advances in monitoring motility, performance of the study in pediatric patients has several limi-tations that should be considered during the procedure and interpretation of the test results. This article reviews the clinical applications of conventional esophageal and anorectal manometries in children by describing a technique for performing the test. This review will develop the uniformity required for the methods of performance, the parame-ters for measurement, and interpretation of test results that could be applied in pediatric clinical practice.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865426
|
oai_dc
|
Clinical Course of Infliximab Treatment in Korean Pediatric Ulcerative Colitis Patients: A Single Center Experience
|
Clinical Course of Infliximab Treatment in Korean Pediatric Ulcerative Colitis Patients: A Single Center Experience
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김종민(성균관대학교); 이유민(성균관대학교); 강빈(성균관대학교); 최연호(성균관대학교)"
] |
Purpose: Infliximab (IFX) is considered safe and effective for the treatment of ulcerative colitis (UC) in both adults and children. The aim of this study was to evaluate the short- and long-term clinical course of IFX in Korean children with UC.
Methods: Pediatric patients with UC who had received IFX infusions between November 2007 and May 2013 at Samsung Medical Center were retrospectively investigated. The clinical efficacy of IFX treatment was evaluated at 8 weeks (short term) and 54 weeks (long term) after the initiation of IFX treatment using the Pediatric Ulcerative Colitis Activity Index (PUCAI). The degree of response to IFX treatment was defined as complete response (PUCAI score=0), partial response (decrement of PUCAI score≥20 points), and non-response (decrement of PUCAI score ＜20 points). Adverse events associated with IFX treatment were also investigated.
Results: Eleven pediatric patients with moderate to severe UC had received IFX. The remission rate after IFX treatment was 46% (5/11) and 82% (9/11) at 8 weeks and 54 weeks after IFX treatment, respectively. All patients who were steroid-dependent before treatment with IFX achieved remission at 54 weeks and were able to stop treatment with corticosteroids, while all steroid-refractory patients failed to achieve remission at 54 weeks after treatment with IFX.
Conclusion: Response to IFX treatment after 8 weeks may predict a favorable long-term response to IFX treatment in Korean pediatric UC patients.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865427
|
oai_dc
|
Molecular Analysis of the UGT1A1 Gene in Korean Patients with Crigler-Najjar Syndrome Type II
|
Molecular Analysis of the UGT1A1 Gene in Korean Patients with Crigler-Najjar Syndrome Type II
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"고재성(서울대학교); 장주영(서울대학교); 문진수(서울대학교병원); 양혜란(서울대학교); 서정기(서울대학교)"
] |
Purpose: Crigler-Najjar syndrome type II (CN-2) is characterized by moderate non-hemolytic unconjugated hyperbilirubinemia as a result of severe deficiency of bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1).
The study investigated the mutation spectrum of UGT1A1 gene in Korean children with CN-2.
Methods: Five Korean CN-2 patients from five unrelated families and 50 healthy controls were enrolled. All five exons and flanking introns of the UGT1A1 gene were amplified by polymerase chain reaction (PCR) and the PCR products were directly sequenced.
Results: All children initially presented with neonatal jaundice and had persistent indirect hyperbilirubinemia.
Homozygous p.Y486D was identified in all five patients. Three patients had an associated homozygous p.G71R and two a heterozygous p.G71R. The allele frequency of p.Y486D and p.G71R in healthy controls was 0 and 0.16, respectively. No significant difference in mean serum bilirubin levels was found between homozygous carriers of p.G71R and heterozygous carriers.
Conclusion: The combination of homozygous p.Y486D and homozygous or heterozygous p.G71R is identified. The p.Y486D and p.G71R can be screened for the mutation analysis of UGT1A1 in Korean CN-2 patients.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865428
|
oai_dc
|
The Rate of Conversion from Immune-tolerant Phase to Early Immune-clearance Phase in Children with Chronic Hepatitis B Virus Infection
|
The Rate of Conversion from Immune-tolerant Phase to Early Immune-clearance Phase in Children with Chronic Hepatitis B Virus Infection
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"홍석진(대구가톨릭대학교 의과대학 소아과학교실); 박효정(경북대학교); 주미애(경북대학교); 최봉석(경북대학교); 최병호(경북대학교)"
] |
Purpose: The spontaneous seroconversion rate of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) virus infection in children is lower than that in adults. However, few studies have investigated the rate of transition from the immune-tolerant to the early immune-clearance phase in children.
Methods: From February 2000 to August 2011, we enrolled 133 children aged ＜18 years who had visited the Department of Pediatrics, Kyungpook National University Hospital. All subjects were in the immune-tolerant phase of HBeAg-positive CHB virus infection. The estimated transition rate into the early immune-clearance phase was calculated using the Kaplan-Meier method.
Results: Among the 133 enrolled pediatric CHB virus infection patients in the HBeAg-positive immune-tolerant phase, only 21 children (15.8%) had converted to the early immune-clearance phase. The average age at entry into active hepatitis was 10.6±4.8 years. The incidence of transition from the immune-tolerant to the early immune-clearance phase in these children was 1.7 episodes/100 patient-years. When analyzed by age, the estimated transition rate was 4.6%, 7.1%, and 28.0% for patients aged ＜6, 6-12, ＞12 years, respectively.
Conclusion: In children with CHB virus infection, the estimated rate of entry into the early immune-clearance phase was 28.0% for patients aged 12-18 years, which was significantly higher than that observed for children aged ＜12 years (11.7%; p=0.001).
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865429
|
oai_dc
|
Neonatal Late-onset Hypocalcemia: Is There Any Relationship with Maternal Hypovitaminosis D?
|
Neonatal Late-onset Hypocalcemia: Is There Any Relationship with Maternal Hypovitaminosis D?
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"도현정(경상대학교); 박지숙(경상대학교); 서지현(경상대학교); 이은신(경상대학교); 박찬후(경상대학교); 우향옥(경상대학교); 윤희상(경상대학교)"
] |
Purpose: Neonatal late-onset hypocalcemia is defined as hypocalcemia developed after postnatal 3 days and associated with hypoparathyroidism, high phosphate diets and vitamin D deficiency. We experienced the increment of neonatal late onset hypocalcemia over 1 year. We tried to evaluate the relationship between late onset hypocalcemia and maternal hypovitaminosis D.
Methods: The medical records in the neonates with late-onset hypocalcemia during January 2007 to July 2008 were retrospectively reviewed. Among those patients, 17 paired sera of mothers and neonates had collected. The levels of 25-OH vitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured and were compared with neonate and the mother.
Results: The mean gestational age was 38+1 weeks, and the mean body weight was 2,980 g. The onset time of hypocalcemia was 5.9 days of age. Most of them (88.2%) were feeding with formula and no one was only breast milk feeding. Of the 17 patients, 13 were born in spring or in winter. The median levels of calcium, phosphorus, alkaline phosphatase, iPTH and 25OHD were 7.0 mg/dL, 8.6 mg/dL, 191.0 U/L, 57.2 pg/mL and 24.0 ng/mL in neonates.
The levels of 25OHD of 6 neonates were ＜20 ng/mL. A total of 16 mothers were considered vitamin D-deficient (＜20 ng/mL), and vitamin D insufficient (20＜25OHD＜30 ng/mL).
Conclusion: Neonatal late-onset hypocalcemia in our study seems to be influenced by maternal vitamin D deficiency and insufficiency. Sun tanning and vitamin D supplements from winter to spring would be helpful to prevent maternal vitamin D deficiency, one of the causes of neonatal late-onset hypocalcemia.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865430
|
oai_dc
|
Gastrointestinal Tract Involvement of Gorham’s Disease with Expression of D2-40 in Duodenum
|
Gastrointestinal Tract Involvement of Gorham’s Disease with Expression of D2-40 in Duodenum
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"최봉석(경북대학교); 홍석진(경북대학교); 주미애(경북대학교); 이석종(경북대학교); 이종민(경북대학교); 배한익(경북대학교); 최병호(경북대학교)"
] |
We present a case of a 13-year-old boy with Gorham’s disease involving the thoracic and lumbar spine, femur, and gastrointestinal (GI) tract, which was complicated by recurrent chylothorax and GI bleeding. The presenting symp-toms were intermittent abdominal pain, back pain, and melena. Esophagogastroduodenoscopy and colonoscopy showed no abnormal lesions, but duodenal biopsy showed marked dilation of the lymphatics in the mucosa and submucosa, which revealed positive staining with a D2-40 immunohistochemical marker. In cases of GI bleeding with osteolysis, the expression of a D2-40 marker in the lymphatic endothelium of the GI tract may help to diagnose GI involvement in Gorham’s disease. To the best of our knowledge, this is the first case report to pathologically demon-strate intestinal lymphatic malformation as a cause of GI bleeding in Gorham’s disease.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001865431
|
oai_dc
|
Epstein-Barr Virus Infection with Acute Acalculous Cholecystitis
|
Epstein-Barr Virus Infection with Acute Acalculous Cholecystitis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김아리(서울대학교병원); 양혜란(서울대학교); 문진수(서울대학교병원); 장주영(서울대학교); 고재성(서울대학교)"
] |
Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder in the absence of demonstrated stones. AAC is frequently associated with severe systemic inflammation. However, the exact etiology and pathogenesis of AAC still remain unclear. Acute infection with Epstein Barr virus (EBV) in childhood is usually aymptomatic, whereas it often presents as typical infectious mononucleosis symptoms such as fever, cervical lymphadenopathy, and hepatosplenomegaly. AAC may occur during the course of acute EBV infection, which is rarely encountered in the pediatric population. AAC complicating the course of a primary EBV infection is usually associated with a favorable outcome. Most of the patients recover without any surgical treatment. Therefore, the detection of EBV in AAC would be important for prediction of better prognosis. We describe the case of a 10-year-old child who presented with AAC during the course of primary EBV infection, the first in Korea, and review the relevant literature.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786845
|
oai_dc
|
Dietary Supplements Use and Related Factors of Preschoolers in 3 Korean Cities
|
Dietary Supplements Use and Related Factors of Preschoolers in 3 Korean Cities
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김혜실(예수병원 소아청소년과); 이혜영(예수병원 소아청소년과); 김미경(예수병원 소아청소년과)"
] |
Purpose: To estimate the prevalence of dietary supplement (DS) use, investigate the related factors associated with DS use among preschoolers and support the adequate nutrition.
Methods: We conducted a questionnaire survey of mothers of children aged between 1 and 6 years who visited pediatric clinics in 3 Korean cities (Jeonju, Suncheon, Jeongeup) between October and November 2012 at Presbyterian Medical Center. The responses from 929 questionnaires were analyzed.
Results: Approximately 45.1% of the preschoolers used DS in the past month. The following factors were associated with greater use of DS: older age (p＜0.001), whether or not the preschoolers attended kindergarten (p＜0.001), higher mother’s concern about the nutritional facts (p＜0.001), whether or not the mother use DS (p＜0.001), whether or not the mother counsel with a doctor or pharmacist about DS use (p＜0.001). Vitaminㆍmineral supplements (77.5%) were the most commonly used DS among the preschoolers, followed by ginseng (49.3%) and probiotics (25.6%). Additionally, of the DS users, 95.9% gave DS to their healthy children. Of the users and non-users, 97.6% and 62.2%, respectively, indicated that they would like to have their children take DS. The information on DS was obtained from family or friends in 48.2% of the DS users and from doctors in only 6.1%.
Conclusion: Approximately half of the preschoolers in our study used DS, which might not have been medically indicated for most of them. Therefore, the role of professionals in counseling on desirable diet behaviors and DS use for preschoolers is warranted. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 104∼115)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786825
|
oai_dc
|
Current Role of Lamivudine Regarding Therapeutic Response and Resistance in Children with Chronic Hepatitis B
|
Current Role of Lamivudine Regarding Therapeutic Response and Resistance in Children with Chronic Hepatitis B
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"홍석진(경북대학교); 김여향(경북대학교); 최병호(경북대학교); 박효정(경북대학교); 탁원영(경북대학교); 권영오(경북대학교)"
] |
Purpose: To identify the predictive factors of long-term therapeutic response or resistance to lamivudine treatment in children and adolescents with chronic hepatitis B.
Methods: Eighty one children and adolescents with chronic hepatitis B were included, who received lamivudine treatment for at least 6 months. Their condition was monitored for at least 12 months (12-88 months) thereafter. Twenty one (25.9%) were preschool children (age≤6). For patients who had developed HBeAg seroconversion or breakthrough, univariate and multivariate analyses were used to identify the effects of age, gender, pretreatment alanine aminotransferase (ALT) and hepatitis B virus DNA levels.
Results: HBeAg seroconversion occurred in 49 (60.5%) of the 81 patients after the initiation of the lamivudine therapy. In 65 patients whom were monitored for over 24 months, the seroconversion rate was significantly higher in younger patients (p=0.040), especially in those patients of preschool age (age≤6, p=0.031). The seroconversion rate was significantly higher in higher pretreatment ALT (p=0.003). The breakthrough occurred in 21 (25.9%) of the 81. The breakthrough rate was lower in younger aged patients (age≤6), and with higher pretreatment ALT levels, but no significant difference.
Conclusion: Younger age is a good predictor of HBeAg seroconversion in children with long-term lamivudine treatment as well as high pretreatment ALT levels. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 80∼88)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786801
|
oai_dc
|
Current Status and Future Promise of the Human Microbiome
|
Current Status and Future Promise of the Human Microbiome
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김봉수(서울대학교); 전윤성(서울대학교); 천종식(서울대학교)"
] |
The human-associated microbiota is diverse, varies between individuals and body sites, and is important in human health. Microbes in human body play an essential role in immunity, health, and disease. The human microbiome has been studies using the advances of next-generation sequencing and its metagenomic applications. This has allowed investigation of the microbial composition in the human body, and identification of the functional genes expressed by this microbial community. The gut microbes have been found to be the most diverse and constitute the densest cell number in the human microbiota; thus, it has been studied more than other sites. Early results have indicated that the imbalances in gut microbiota are related to numerous disorders, such as inflammatory bowel disease, colorectal cancer, diabetes, and atopy. Clinical therapy involving modulating of the microbiota, such as fecal transplantation, has been applied, and its effects investigated in some diseases. Human microbiome studies form part of human genome projects, and understanding gleaned from studies increase the possibility of various applications including personalized medicine. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 71∼79)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786863
|
oai_dc
|
A Case of Rapunzel Syndrome
|
A Case of Rapunzel Syndrome
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김준성(울산대학교); 남창우(울산대학교)"
] |
Rapunzel syndrome refers to a very rare condition in which swallowed hair forms a gastric trichobezoar that has a long tail extending into the small bowel. We describe a case of Rapunzel syndrome in an 8-year-old girl who presented with abdominal mass, epigastric pain and vomiting. Abdominal computed tomography scan showed a markedly dilated stomach filled with coarse heterogeneous materials. Upper gastrointestinal endoscopy revealed a huge hairy ball with a tail extending through the pylorus. We performed a surgical laparotomy and successfully removed a huge trichobezoar with a long tail extending into the middle portion of jejunum. Psychiatric consultation with review showed her past history of trichotillomania and trichophagia 4 years ago. But her parents denied further psychiatric therapy and she was lost to the follow-up. Rapunzel syndrome should be included in the differential diagnosis in children with chronic abdominal pain and trichophagia. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 127∼130)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786860
|
oai_dc
|
Co-Infection with Cytomegalovirus and Helicobacter pylori in a Child with Ménétrier’s Disease
|
Co-Infection with Cytomegalovirus and Helicobacter pylori in a Child with Ménétrier’s Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"유양호(성균관대학병원); 이윤송(성균관대학교); 이유민(경희대학교); 최연호(성균관대학교)"
] |
Ménétrier’s disease is a rare protein-losing gastropathy characterized by hypertrophic gastric fold, foveolar hyperplasia, and hypoproteinemia with resulting peripheral edema. It is clinically evident as nonspecific gastrointestinal symptoms, including abdominal discomfort, nausea and vomiting, abdominal pain, weight loss, diarrhea, and edema. Pediatric Ménétrier’s disease usually has an insidious onset and progressive, chronic clinical course and it spontaneously resolves in weeks or months. The pathogenesis of Ménétrier’s disease is not clearly understood. Ménétrier’s disease is thought to be associated with some gastric infections. But the cause of Ménétrier’s disease is unknown, an association with cytomegalovirus (CMV) and Helicobacter pylori has been suggested. In Korea, We present the first a case of pediatric Ménétrier’s disease with positive evidence of CMV and H. pylori. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 123∼126)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786876
|
oai_dc
|
A Case of Cecal Volvulus Presenting with Chronic Constipation in Lissencephaly
|
A Case of Cecal Volvulus Presenting with Chronic Constipation in Lissencephaly
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이은경(영남대학교); 김지은(영남대학교); 이연영(영남대학교); 김세윤(영남대학교); 최광해(영남대학교)"
] |
Cecal volvulus is uncommon in pediatric patients and there are few reports of cecal volvulus with cerebral palsy. Here, we report the case of a 19-year-old male patient who presented with abdominal distension, a history of cerebral palsy, refractory epilepsy due to lissencephaly, and chronic constipation. An abdominal x-ray and computed tomography without contrast enhancement showed fixed dilated bowel intensity in the right lower abdomen. Despite decompression with gastric and rectal tube insertion, symptoms did not improve. The patient underwent an exploratory laparotomy that revealed cecal volvulus. Cecal volvulus usually occurs following intestinal malrotation or previous surgery. In this patient, however, intestinal distension accompanying mental disability and chronic constipation resulted in the development of cecal volvulus. We suggest that cecal and proximal large bowel volvulus should be considered in patients presenting with progressive abdominal distension combined with a history of neuro-developmental delay and constipation. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 131∼134)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786841
|
oai_dc
|
Is It Possible to Predict the Iron Status from an Infant’s Diet History?
|
Is It Possible to Predict the Iron Status from an Infant’s Diet History?
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김형진(인하대학교); 김동현(인하대병원); 이지은(인하대학교); 권영세(인하대학교); 전용훈(인하대학교); 홍영진(인하대학교); 김순기(인하대학교)"
] |
Purpose: Iron deficiency remains a very common nutritional problem despite the improvement in nutrition and increased understanding of methods for its prevention. Thus, we try to create a new method for screening iron nutrition through infant nutrition history.
Methods: Among the children who visited Inha University Hospital from March 2006 to July 2012, 181 children with iron deficiency anemia (IDA) and 52 children without IDA ranging from 6 to 36 months of age were reviewed in this study. We used the age when they began to wean food, the type of sort weaning foods, the time required for successful weaning, iron content in weaning foods, and the duration of breastfeeding for scoring infant nutrition history based on a questionnaire.
Results: The mean score of the IDA group was 7.8±2.6 points, which was significantly higher than that of the control group (5.6±2.1) (p=0.000). If we set up the cutoff value at 6 points, this screening has 86.8% sensitivity and 36% specificity. In addition, as the IDA score increased, there was a falling trend of hemoglobin.
Conclusion: The IDA score does not have high specificity or high sensitivity. However, this study conveys that those patients who record a high score have low hemoglobin. Therefore, we suggest this score system for screening more IDA patients via nonpainful techniques. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 95∼103)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786855
|
oai_dc
|
Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition
|
Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"임미선(서울대학교 의과대학 소아과학교실); 최창원(서울대학교); 김병일(서울대학교); 양혜란(서울대학교)"
] |
Purpose: Preterm infants on parenteral nutrition are at a relatively high risk for hypertriglyceridemia because they have immature lipoprotein lipase activity. The purpose of this study was to analyze the clinical factors affecting lipid metabolism in preterm infants receiving parenteral nutrition and to evaluate the influence of intravenous heparin on serum triglycerides to determine the adequate heparin dose to prevent hypertriglyceridemia in preterm infants.
Methods: A single-center retrospective review was conducted among preterm infants receiving parenteral nutrition between January 2006 and February 2011. In 75 patients, 110 determinations were performed within 28 days postnatal age. Demographic and clinical data, including laboratory parameters, the dose and the duration of lipid administration, and the amount of intravenous heparin, were analyzed.
Results: Serum triglycerides were higher in the small for gestational age (SGA) infants than in the appropriate for gestational age infants (185.5±134.9 mg/dL vs. 126.9±101.9 mg/dL, p=0.019). Birth weight, gestational age, and body weight were negatively correlated with serum triglyceride level (r=−0.289, p=0.002; r=−0.208, p=0.029; r=−0.287, p=0.002, respectively). The serum triglyceride level was statistically lower in preterm infants receiving 1 U/mL of heparin than in those receiving 0.5 U/mL heparin or no heparin.
Conclusion: Preterm infants receiving parenteral nutrition, particularly SGA and extremely low birth weight infants, tend to have hypertriglyceridemia. Thus, administration of 1 U/mL of heparin rather than 0.5 U/mL or none may be helpful to prevent hypertriglyceridemia in preterm infants. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 116∼122)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786790
|
oai_dc
|
Monitoring and Safety of Azathioprine Therapy in Inflammatory Bowel Disease
|
Monitoring and Safety of Azathioprine Therapy in Inflammatory Bowel Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김미진(인제대학교); 최연호(성균관대학교)"
] |
Azathioprine is the most common drug used to maintain clinical remission in inflammatory bowel disease. This drug is also important as a steroid-sparing agent in steroid-dependent and chronically active inflammatory bowel disease. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine. The dose of azathioprine has to be reduced or the therapy has to be discontinued frequently because of drug-induced toxicity. In this review, we discuss monitoring of thiopurines, adverse events, malignant complications and how to use azathioprine safely and usefully. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 65∼70)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001786834
|
oai_dc
|
Increase in Aminotransferase Levels during Urinary Tract Infections in Children
|
Increase in Aminotransferase Levels during Urinary Tract Infections in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"박주이(건양대학교 의과대학 소아과학교실); 고경옥(건양대학교 의과대학 소아과학교실); 임재우(건양대학교); 전은정(건양대학교 의과대학 소아과학교실); 윤정민(건양대학교)"
] |
Purpose: The aim of this study was to evaluate the prevalence of increased aminotransferase levels and to identify associated factors in children admitted to hospital with urinary tract infections (UTIs).
Methods: The study included children with a diagnosis of UTI who were admitted to the Konyang University Hospital from January 2007 to May 2011. The total number of patients was 249 and the mean age was 15.88±28.21 months. UTI was defined as a positive urine culture (＞105/colony forming unit [CFU]) with pyrexia. Patients were treated by intravenous antibiotics, such as ampicillin/sulbactam, aminoglycoside, cephalosporins or vancomycin. Patients with neonatal jaundice or other liver disease were excluded. We investigated the relationship of aminotransferase levels with the type of antibiotic, degree of vesicoureteral reflux (VUR), and causative organisms.
Results: Children with increased aminotransferase levels were younger than those with normal levels (p=0.001), but white blood cell count, platelet count, causative organisms, type of antibiotics and presence of VUR were not associated with aminotransferase levels. Aminotransferase levels became normal within 1 month after discharge without special measures, except in 1 case.
Conclusion: We found that many children with UTI have abnormal aminotransferase levels. In most cases, this change is mild and self-limiting. We conclude that increased aminotransferase level increase during UTI do not require unnecessary tests and excessive treatment. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 89∼94)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811639
|
oai_dc
|
Reappraisal of Regional Growth Charts in the Era of WHO Growth Standards
|
Reappraisal of Regional Growth Charts in the Era of WHO Growth Standards
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"문진수(서울대학교병원)"
] |
After the WHO Growth Standards (WHOGS) was published in 2006, many countries in the world endorsed and adopt-ed the new growth references as a standard measure for the growth of infants and young children. Certainly, the WHOGS has an impact on the global policy about obesity and underweight in children. Such WHOGS innovation has influenced many regional health authorities and academies, which have managed their own growth charts for a long time, in changing their strategies to develop and use regional growth charts. In Korea, along with the tradition to create a national growth chart every decade, we now face a new era of advancing with the WHOGS. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 137∼142)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811654
|
oai_dc
|
Pre-diagnostic Clinical Presentations and Medical History Priorto the Diagnosis of Inflammatory Bowel Disease in Children
|
Pre-diagnostic Clinical Presentations and Medical History Priorto the Diagnosis of Inflammatory Bowel Disease in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"권용훈(한양대학교); 김용주(한양대학교)"
] |
Purpose: The clinical presentations of inflammatory bowel disease (IBD) prior to diagnosis are so diverse or vague that many of them waste time before final diagnosis. This study was undertaken to know the medical history of the pediatric patients until the final diagnosis could be reached. Methods: The medical records of all pediatric patients who were diagnosed with IBD (Crohn’s disease [CD] in 14 children, ulcerative colitis [UC] in 17) during the last 13 years were reviewed. We investigated the length of the diag-nostic time lag, chief clinical presentation, and any useful laboratory predictor among the routinely performed examinations. Indeterminate colitis was not included.Results: The mean ages of children at the final diagnosis was similar in both diseases. As for the pre-clinical past history of bowel symptoms in CD patients, 5 were previously healthy, 9 had had 1-3 gastrointestinal (GI) symptoms, weight loss, bloody stool, anemia and rectal prolapse. With UC, 9 were previously healthy, 8 had had 1-3 GI symptoms, bloody stool, anorexia. The average diagnostic time lag with CD was 3.36 months, and with UC 2.2 months. Body mass index (BMI) and the initial basic laboratory data (white blood cell, hemoglobin, mean corpuscular volume, serum albumin, and serum total protein) were lower in CD, statistically significant only in BMI. Conclusion: IBD shows diverse clinical symptoms before its classical features, making the patients waste time until diagnosis. It is important to concern possibility of IBD even in the mildly sick children who do not show the characteristic symptoms of IBD. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 178∼184)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811652
|
oai_dc
|
Adverse Events Associated with Azathioprine Treatment in Korean Pediatric Inflammatory Bowel Disease Patients
|
Adverse Events Associated with Azathioprine Treatment in Korean Pediatric Inflammatory Bowel Disease Patients
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"천지영(성균관대학교); 강빈(성균관대학교); 이유민(성균관대학교); 이수연(성균관대학교); 김미진(인제대학교); 최연호(성균관대학교)"
] |
Purpose: This study was aimed to evaluate the frequency and course of adverse events associated with azathioprine treatment in Korean pediatric patients with inflammatory bowel disease. Methods: Total of 174 pediatric patients (age range, 1 to 19 years) with inflammatory bowel disease who received azathioprine in order to maintain remission at Samsung Medical Center (Seoul, Korea) from January 2002 through December 2012 were included in this study. Medical records of these subjects were retrospectively reviewed regard-ing the development of adverse events associated with azathioprine treatment.Results: Ninety-eight patients (56.3%) of 174 patients experienced 136 episodes of adverse events, requiring dose reduction in 31 patients (17.8%), and discontinuation in 18 patients (10.3%). The mean dose of azathioprine that had been initially administered was 1.32±0.42 mg/kg/day. Among the adverse reactions, bone marrow suppression developed in 47 patients (27.0%), requiring dose reduction in 22 patients (12.6%) and discontinuation in 8 patients (4.6%). Other adverse events that occurred were gastrointestinal disturbance (15.5%), hair loss (12.1%), pancreatitis (7.5%), arthralgia (6.9%), hepatotoxicity (2.9%), skin rash/allergic reactions (2.9%), headache/dizziness (2.3%), sepsis (0.6%), and oral mucositis (0.6%). Conclusion: Bone marrow suppression, especially leukopenia was most commonly associated with azathioprine treatment in Korean pediatric inflammatory bowel disease patients. Close observation for possible adverse events is required in this population with inflammatory bowel diseases who are under treatment with azathioprine. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 171∼177)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811644
|
oai_dc
|
Polyunsaturated Fatty Acids in Children
|
Polyunsaturated Fatty Acids in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이지혁(충북대학교)"
] |
Polyunsaturated fatty acids (PUFAs) are the major components of brain and retina, and are the essential fatty acids with important physiologically active functions. Thus, PUFAs should be provided to children, and are very important in the brain growth and development for fetuses, newborn infants, and children. Omega-3 fatty acids decrease coro-nary artery disease and improve blood flow. PUFAs have been known to have anti-inflammatory action and improved the chronic inflammation such as auto-immune diseases or degenerative neurologic diseases. PUFAs are used for metabolic syndrome related with obesity or diabetes. However, there are several considerations related with intake of PUFAs. Obsession with the intake of unsaturated fatty acids could bring about the shortage of essential fatty acids that are crucial for our body, weaken the immune system, and increase the risk of heart disease, arrhythmia, and stroke. In this review, we discuss types, physiologic mechanism of action of PUFAs, intake of PUFAs for children, recommended intake of PUFAs, and considerations for the intake of PUFAs. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 153∼161)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811661
|
oai_dc
|
Congenital Internal Hernia Presented with Life Threatening Extensive Small Bowel Strangulation
|
Congenital Internal Hernia Presented with Life Threatening Extensive Small Bowel Strangulation
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이나래(부산대학교 양산병원); 김수곤(부산대학교 양산병원); 이연주(부산대학교 양산병원); 박재홍(부산대학교); 손성국(부산대학교 양산병원); 김수홍(부산대학교); 황재연(부산대학교 양산병원)"
] |
Internal hernia (IH) is a rare cause of small bowel obstruction occurs when there is protrusion of an internal organ into a retroperitoneal fossa or a foramen in the abdominal cavity. IH can be presented with acute or chronic abdominal symptom and discovered by accident in operation field. However, various kinds of imaging modalities often do not provide the assistance to diagnose IH preoperatively, but computed tomography (CT) scan has a high diagnostic accuracy. We report a case of congenital IH in a 6-year-old boy who experienced life threatening shock. CT scan showed large amount of ascites, bowel wall thickening with poor or absent enhancement of the strangulated bowel segment. Surgical exploration was performed immediately and had to undergo over two meters excision of strangu-lated small bowel. To prevent the delay in the diagnosis of IH, we should early use of the CT scan and take urgent operation. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 190∼194)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811663
|
oai_dc
|
Congenital Chloride Diarrhea in Dizygotic Twins
|
Congenital Chloride Diarrhea in Dizygotic Twins
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"서경아(중앙대학교); 이나미(중앙대학교); 김광준(중앙대학교); 윤신원(중앙대학교); 채수안(중앙대학교); 임인석(중앙대학교); 최응상(중앙대학교); 유병훈(중앙대학교)"
] |
Congenital chloride diarrhea (CLD) is a rare inherited autosomal recessive disorder. Mutations of the solute carrier family 26 member 3 gene cause profuse, chloride ion rich diarrhea, which results in hypochloremia, hyponatremia and metabolic alkalosis with dehydration. If a fetal ultrasound shows bowel dilatation suggestive of bowel obstruction, or if a neonate shows persistent diarrhea and metabolic alkalosis, CLD should be considered in the differential diagnosis. The severity of CLD varies, but early detection and early therapy can prevent complications including growth failure. We report a case of dizygotic twins affected by CLD who had been born to non-consanguineous parents. Both of them showed growth failure, but one of the twins experienced worse clinical course. He showed developmental delay, along with dehydration and severe electrolyte imbalance. He was diagnosed with CLD first at 6-month age, and then the other one was also diagnosed with CLD. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 195∼199)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811667
|
oai_dc
|
Acute Urinary Retention in a 47-month-old Girl Caused by the Giant Fecaloma
|
Acute Urinary Retention in a 47-month-old Girl Caused by the Giant Fecaloma
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"박지숙(경상대학교); 박태진(경상대학교); 화정석(경상대학교); 서지현(경상대학교); 박찬후(경상대학교); 윤희상(경상대학교)"
] |
We present a case of a 47-month-old female suffering from acute urinary bladder neck obstruction and bilateral hydro-nephrosis secondary to a fecaloma. Fecaloma is defined as an accumulation of inspissated feces in the colon or rectum giving the appearance of an abdominal mass. A fecaloma can be developed by diverse causes and the causes of the fecaloma in this case were septum reformation after the Duhamel procedure and long-term constipation. Chronic constipation is very common at outpatient clinic. However, acute urinary retention and voiding difficulty caused by fecaloma in the giant Duhamel pouch has never been reported in Korea. We would like to present our case with acute urinary retention due to a fecaloma and suggest that fecaloma might be considered as one of the causes for acute urinary retention, especially in cases with previous Duhamel operation for repair of Hischsprung disease. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 200∼205)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811645
|
oai_dc
|
Clinical Features and Role of Viral Isolates from Stool Samples of Intussuception in Children
|
Clinical Features and Role of Viral Isolates from Stool Samples of Intussuception in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이용욱(충남대학교); 양수인(충남대학교); 김지명(충남대학교병원); 김재영(충남대학교)"
] |
Purpose: To detect major acute gastroenteritis virus (rotavirus, norovirus, astrovirus, and enteric adenovirus) and non-enteric type of adenovirus (AdV) in the stools of intussusception patients and to investigate the clinical role of detected viruses. Methods: From March 2012 to February 2013, major acute gastroenteritis virus and non-enteric type of AdV were isolated from stool samples that collected from 44 patients treated for intussusception in Chungnam National University Hospital. Patients were divided according to age and isolated virus. Results: Virus was detected in 28 (63%) stool specimens. The virus detection rate was significantly lower in patients aged under 12 months (p = 0.04). Twenty-two patients (78.6%) had non-enteric adenovirus, 4 (14.3%) had norovirus, 1 (3.6%) had sapovirus, and 1 (3.6%) had astrovirus. AdV subgroup C (AdV 1, 2, 5, and 6) comprised the majority with 20 cases (90.9%). A monthly increment-and-decrement pattern of intussusception was similar to that of viral detection in the stool samples. Enema reductions were successful in 39 patients and surgical manual reductions were performed in 5 patients. Virus was detected in 24 patients (61.5%) of enema reduction group and 4 patients (80.0%) of surgical manual reduction group. All of the detected viruses were non-enteric adenovirus subgroup C (AdV 1, 5, and 6) in surgical reduction patients. Conclusions: The virus detection rate was high in the stools of intussusception patients. The pattern of seasonal intussusception occurrence rate was parallel with seasonal these viral detection rate in the stool samples. These findings suggest that viral infection plays an important role in the development of intussusception and further research is warranted. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 162∼170)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811657
|
oai_dc
|
A Case of Esophageal Candidiasis in an Adolescent Who Had Frequently Received Budesonide Nebulizing Therapy
|
A Case of Esophageal Candidiasis in an Adolescent Who Had Frequently Received Budesonide Nebulizing Therapy
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"강해량(한양대학교); 권용훈(한양대학교); 김용주(한양대학교)"
] |
Corticosteroid (budesonide) nebulizer therapy is commonly performed. Its side effects have been considered as being safe or ignorable. The authors present a case of esophageal candidiasis in a healthy female adolescent who was treated with budesonide nebulizer therapy a few times for a cough during the previous winter season. This child pre-sented with dysphagia and epigastric pain for 1 month. Esophageal endoscopy showed a whitish creamy pseudomem-brane and erosions on the esophageal mucosa. Pathologic findings showed numerous candidal hyphae. She did not show any evidence of immunodeficiency, clinically and historically. The esophageal lesion did not resolve naturally. The esophageal lesion completely improved with the antifungal therapy for 2 weeks; the symptoms disappeared, and the patient returned to normal health. It is important that frequent esophageal exposure to topical corticosteroids application can cause unexpected side effects. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 185∼189)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001811641
|
oai_dc
|
Obesity, Inflammation and Diet
|
Obesity, Inflammation and Diet
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이한송이(경희대학교); 이인석(경희대학교); 조여원(경희대학교)"
] |
Obesity is a state in which there is an over-accumulation of subcutaneous and/or abdominal adipose tissue. This adipose tissue is no longer considered inert and mainly devoted to storing energy; it is emerging as an active tissue in the regulation of physiological and pathological processes, including immunity and inflammation. Adipose tissue produces and releases a variety of adipokines (leptin, adiponectin, resistin, and visfatin), as well as pro- and anti-in-flammatory cytokines (tumor necrosis factor-α, interleukin [IL]-4, IL-6, and others). Adipose tissue is also implicated in the development of chronic metabolic diseases such as type 2 diabetes mellitus or cardiovascular disease. Obesity is thus an underlying condition for inflammatory and metabolic diseases. Diet or dietary patterns play critical roles in obesity and other pathophysiological conditions. A healthy diet and some nutrients are generally considered benefi-cial; however, some dietary nutrients are still considered controversial. In this article, dietary factors that influence inflammation associated with obesity are discussed. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 143∼152)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758818
|
oai_dc
|
Life-Threatening Lower Gastrointestinal Hemorrhage in Pediatric Crohn’s Disease
|
Life-Threatening Lower Gastrointestinal Hemorrhage in Pediatric Crohn’s Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김얼(세브란스어린이병원); 강윤구(세브란스어린이병원); 이미정(연세대학교); 박영년(연세대학교); 고홍(연세대학교)"
] |
In Crohn’s disease, mild gastrointestinal bleeding often occurs; however massive gastrointestinal hemorrhage, which can have a dramatic effect on a patient’s vital sign, is rare. This could result in potentially life-threatening complications, which can lead to death. Massive hemorrhagic Crohn’s disease is not well known and for this reason, they are a diagnostic and therapeutic challenge. Various diagnostic and therapeutic methods are currently being developed and used. The surgical method is often used only as a last measure since this approach has the risk of serious complications that may endanger patients. However, if massive bleeding continues even after all therapeutic methods are used, the surgical method must be implemented. In this case, all therapeutic methods were found to be ineffective; therefore, surgery was used as a last option. Ultimately, the surgical method was found to be successfully used to treat life-threatening hemorrhagic Crohn’s disease. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 53∼60)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758772
|
oai_dc
|
Gut Microbiota in Inflammatory Bowel Disease
|
Gut Microbiota in Inflammatory Bowel Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"심정옥(고려대학교 의학과)"
] |
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesisof inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a geneticpredisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD.
A condition of “dysbiosis”, with alterations of the gut microbial composition, has been observed in patients with IBD.
In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiotain the pathogenesis of pediatric IBD. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 17∼21)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758797
|
oai_dc
|
Influencing Factors to Results of the Urease Test: Age, Sampling Site, Histopathologic Findings, and Density of Helicobacter pylori
|
Influencing Factors to Results of the Urease Test: Age, Sampling Site, Histopathologic Findings, and Density of Helicobacter pylori
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"서지현(경상대학교); 윤희상(경상대학교); 박정제(경상대학교); 염정숙(경상대학교); 박지숙(경상대학교); 전진수(경상대학교); 임재영(경상대학교); 박찬후(경상대학교); 우향옥(경상대학교); 고경혁(경상대학교); 백승철(경상대학교); 이우곤(경상대학교); 조명제(경상대학교); 이광호(경상대학교)"
] |
Purpose: We investigated the positivity rate and the time period to the positive color change of the urease test in children and adults and assessed the correlation of the urease test to histopathologic findings.
Methods: From 1995 to 2000, endoscopic biopsies of the antrum and body were collected from 811 children and 224 adults and subjected to urease tests and histopathology.
Results: The positivity rate of the urease test was 49.4% for 0-4 years, 48.4% for 5-9 years, 47.3% for 10-15 years, and 62.5% for 20-29 years in the antrum. The positivity rate was 85.1% in 0-4 years, 82.3% in 5-9 years, 74.7% in 10-15 years, and 74.1% in 20-29 years for the body. In the antrum, the highest positivity rate was ＜1 hour for the group aged 10-29 years and 6-24 hours in the group ＜10 years old (p＜0.0001). In the body, the highest positivity rate was ＜1 hour in adults and 6-24 hours in children (p＜0.0001). The proportions of the positive reactions within 1 hour were similar for the antrum and the body. In the cases of more severe chronic gastritis, active gastritis, and Helicobacter pylori infiltration, a positive urease test reaction occurred more quickly (p＜0.0001).
Conclusion: There were significant differences in urease tests according to age and sampling site. The discrepancy between the antrum and the body was greater in younger children. These results might be related to the low density and patchy distribution of bacteria in children and in the body. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 34∼40)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758813
|
oai_dc
|
Congenital Antral Web in Premature Baby
|
Congenital Antral Web in Premature Baby
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"남소현(인제대학교); 구수현(인제대학교 해운대백병원); 정미림(인제대학교 해운대백병원); 정유진(인제대학교 해운대백병원); 임윤정(인제대학교 해운대백병원)"
] |
Antral web is a rare cause of gastric outlet obstruction in neonate. It is a 2-4 mm thin mucous membrane that can be found anywhere from 1 to 7 cm proximal to the pylorus. The baby was born at gestational age of 32+1 weeks with 1,880 g as 2nd baby of dizygotic twin. After birth, the baby had constant non-bilious vomiting without feeding while he didn’t show abdominal distension or discoloration. The infantogram showed distended stomach with distal small bowel gas. Upper gastrointestinal series revealed that the antrum was abruptly narrowed at 1 cm proximal to pylorus. We performed laparotomy at the 10th day after birth and excised the 2 mm-thick web circumferentially. He began milk feeding after 6 days and discharged uneventfully at postoperative 35 days with corrected age of 38+4 weeks with body weight 2,420 g. The antral web should be considered in the case of non-bilious vomiting in neonate. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 49∼52)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758778
|
oai_dc
|
Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver Disease
|
Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"박지숙(경상대학교); 서지현(경상대학교); 윤희상(경상대학교)"
] |
The prevalence of obesity is increasing worldwide. Obesity can cause hyperlipidemia, hypertension, cardiovasculardiseases, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Many environmental or genetic factorshave been suggested to contribute to the development of obesity, but there is no satisfactory explanation for its increasedprevalence. This review discusses the latest updates on the role of the gut microbiota in obesity and NAFLD.(Pediatr Gastroenterol Hepatol Nutr 2013; 16: 22∼27)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758807
|
oai_dc
|
Clinical Features of Symptomatic Meckel's Diverticulum in Children: Comparison of Scintigraphic and Non-scintigraphic Diagnosis
|
Clinical Features of Symptomatic Meckel's Diverticulum in Children: Comparison of Scintigraphic and Non-scintigraphic Diagnosis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"노정희(가천대학교); 김재숙(인하대학교); 김상용(가톨릭대학교); 김순기(인하대학교); 최윤미(인하대학교); 김성민(가톨릭대학교); 차한(가천대학교); 전인상(가천대학교); 손동우(가천대학교); 류일(가천대학교); 조강호(가천대학교); 최덕영(가천대학교); 김윤미(가천대학교)"
] |
Purpose: Meckel's diverticulum (MD) has various clinical manifestations, and diagnosis or selectection of proper diagnostic tools is not easy. This study was conducted in order to assess the clinical differences of MD diagnosed by scintigraphic and non-scintigraphic methods and to find the proper diagnostic tools.
Methods: We conducted a retrospective review of the clinical, surgical, radiologic, and pathologic findings of 34 children with symptomatic MD, who were admitted to Gachon University Gil Medical Center, Inha University Hospital, and The Catholic University of Korea, Incheon St. Mary’s Hospital between January 2000 and December 2012. The patients were evaluated according to scintigraphic (12 cases; group 1) and non-scintigraphic (22 cases; group 2) diagnosis.
Results: The male to female ratio was 7.5: 1. The most frequent chief complaint was lower gastrointestinal (GI) bleeding in group 1 and nonspecific abdominal pain in group 2, respectively. The most frequent pre-operative diagnosis was MD in both groups. Red blood cell (RBC) index was significantly lower in group 1. MD was located at 7 cm to 85 cm from the ileocecal valve. Four patients in group 1 had ectopic gastric tissues causing lower GI bleeding. The most frequent treatment modality was diverticulectomy in group 1 and ileal resection in group 2, respectively.
Conclusion: To diagnose MD might be delayed unless proper diagnostic tools are considered. It is important to understand indications of scintigraphic and non-scintigraphic methods according to clinical and hematologic features of MD. Scintigraphy would be weighed in patients with anemia as well as GI symptoms. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 41∼48)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758834
|
oai_dc
|
Epstein-Barr Virus Infection with Acute Pancreatitis Associated with Cholestatic Hepatitis
|
Epstein-Barr Virus Infection with Acute Pancreatitis Associated with Cholestatic Hepatitis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"강석진(계명대학교 의과대학 소아과학교실); 윤가현(계명대학교 의과대학 소아과학교실); 황진복(계명대학교)"
] |
Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient’s symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 61∼64)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758763
|
oai_dc
|
Recent Trends in the Endoscopic Management of Variceal Bleeding in Children
|
Recent Trends in the Endoscopic Management of Variceal Bleeding in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김승진(울산대학교 의학과); 김경모(울산대학교)"
] |
Variceal bleeding results in significant morbidity and mortality in both children and adults. The guidelines for themanagement of variceal bleeding are well established in adults but not in children as there have been insufficientpediatric studies of this disorder. In addition, the adult guidelines for treatment of variceal bleeding cannot be applieddirectly to children as the etiology and natural course of this disease differs between children and adults. Examplesof recommended treatments in children include endoscopic variceal ligation as secondary prophylaxis for biliaryatresia whereas a meso-Rex shunt operation for extrahepatic portal vein obstruction. In this review, we discuss prophylaxisoptions and some technical aspects of endoscopic management for variceal bleeding in children. (PediatrGastroenterol Hepatol Nutr 2013; 16: 1∼9)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758783
|
oai_dc
|
Anorectal Malformations Associated with Esophageal Atresia in Neonates
|
Anorectal Malformations Associated with Esophageal Atresia in Neonates
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"변신연(부산대학교); 임령경(부산대학교); 박경희(부산대학교); 조용훈(부산대학교); 김해영(부산대학교)"
] |
Purpose: Anorectal malformations are often associated with other anomalies, reporting frequency with 40-70%. Gastrointestinal anomalies have been known to be relatively less common than associated anomalies of other organ system. This study was performed to assess a distinctive feature of cases associated with esophageal atresia.
Methods: Clinical data (from January 2000 through December 2011) on the 196 subjects with anorectal malformations, managed in our Hospital, were reviewed. Total 14 neonates were identified with accompanying esophageal atresia and retrospective analysis was conducted.
Results: The incidence was 7.1% and there were 8 male and 6 female subjects. Only 2 cases were associated with esophageal atresia without tracheoesophageal fistula. Although variable cases of anorectal malformation in female subjects, almost cases were anorectal malformations with rectourethral fistula in male. Other associated anomalies were identified in all cases, with more than 3 anomalies in 10 cases. There were 4 VACTERL (Vertebral abnormalities, Anal atresia, Cardiac anomalies, Tracheoesophageal fistula, Esophageal atresia, Renal and Limb anomalies) associations accounting for 28.6%, but could not identify chromosomal anomaly. Most cases were managed with staged procedure, usually primary repair of esophageal atresia and diverting colostomy. Overall mortality rate was 21.4%, mainly caused by heart problems.
Conclusion: This study shows that early diagnosis and rational surgical approach with multidisciplinary plan are mandatory in managing anorectal malformations with esophageal atresia, when considering a high frequency of associated anomaly and a relative high mortality. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 28∼33)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001758770
|
oai_dc
|
Recent Achievements in Stem Cell Therapy for Pediatric Gastrointestinal Tract Disease
|
Recent Achievements in Stem Cell Therapy for Pediatric Gastrointestinal Tract Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"배선환(건국대학교)"
] |
The field of stem cell research has been rapidly expanding. Although the clinical usefulness of research remainsto be ascertained through human trials, the use of stem cells as a therapeutic option for currently disabling diseasesholds fascinating potential. Many pediatric gastrointestinal tract diseases have defect in enterocytes, enteric nervoussystem cells, smooth muscles, and interstitial cells of Cajal. Various kinds of therapeutic trials using stem cells couldbe applied to these diseases. This review article focuses on the recent achievements in stem cell applications forpediatric gastrointestinal tract diseases. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 10∼16)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702098
|
oai_dc
|
Current Status of Intestinal Failure and Intestinal Transplantation
|
Current Status of Intestinal Failure and Intestinal Transplantation
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"고재성(서울대학교)"
] |
Pediatric intestinal failure occurs secondary to short bowel syndrome, motility disorders, or malabsorption. The establishment of an intestinal rehabilitation program and the introduction of innovative surgical and medical treatments, such as the serial transverse enteroplasty procedure and omega-3-containing lipid emulsions, have been major advances in the treatment of intestinal failure. Intestinal transplantation is now established as a therapeutic modality in selected children with irreversible intestinal failure. The improved short to intermediate term survival of intestinal transplant recipients in the last decade can be attributed to immunosuppression with a lymphocyte-depleting agent, control of acute cellular rejection, and comprehensive infection control with careful monitoring of viral pathogens including cytomegalovirus and Epstein-Barr virus.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702336
|
oai_dc
|
Two Cases of Pediatric Collagenous Gastritis Each Presenting with Refractory Iron Deficiency Anemia and Chronic Diarrhea
|
Two Cases of Pediatric Collagenous Gastritis Each Presenting with Refractory Iron Deficiency Anemia and Chronic Diarrhea
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Yeoun Joo Lee(Ulsan University); 김경모(울산대학교); Seok Hee Oh(Ulsan University); Seung Min Song(Ulsan University); 유은실(울산대학교); 고경남(울산대학교)"
] |
Collagenous gastritis (CG) is a rare disorder that is characterized by the presence of a thick subepithelial collagen band with multiple infiltrated inflammatory cells of the gastric mucosa. CG is divided into two major subsets: first, in children and young adults presenting with severe anemia and abdominal colic pain (pediatric-type CG); and second, in adult patients with chronic watery diarrhea associated with collagenous colitis (adult-type CG). We report two cases of pediatric-type CG, each presenting with refractory anemia and chronic diarrhea.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702122
|
oai_dc
|
Childhood Obesity and Pubertal Development
|
Childhood Obesity and Pubertal Development
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Shin Hye Kim(Inje University); 박미정(인제대학교)"
] |
During the past decades, advancement in pubertal maturation in children has been noticed worldwide. Growing evidence indicates that increasing prevalence of obesity in children is a major factor for the secular trend of earlier puberty. In girls, several epidemiologic studies suggest that earlier pubertal onset and earlier menarche might be caused by obesity. On the other hand, in boys, few research reported an association between obesity and pubertal development, and the results are inconsistent; Some studies found a link between obesity and delayed puberty, but others reported a causal relationship between obesity and early puberty. To date, mechanisms linking childhood obesity and earlier puberty remain unclear. In this review, we presented the potential impact of obesity on puberty-related hormones and summarized human studies on potential relationship of childhood adiposity and pubertal development.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702349
|
oai_dc
|
Diffuse Colonic Ulcer Caused by Salmonella enteritidis in a 32-month-old Female
|
Diffuse Colonic Ulcer Caused by Salmonella enteritidis in a 32-month-old Female
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Jae-Young Cho(Gyeongsang National University); 서지현(경상대학교); Jung Sook Yeom(Gyeongsang National University); Ji Sook Park(Gyeongsang National University); 박찬후(경상대학교); 우향옥(경상대학교); 윤희상(경상대학교)"
] |
Nontyphoidal Salmonella is a type of well-known foodborne pathogen that causes gastroenteritis, bacteremia, and subsequent focal infection. Moreover, colonic ulcers, caused by nontyphoidal Salmonella infection, are considered uncommon in children. We report on the case of a 32-month-old healthy female with diffuse left-side colonic ulcers that presented with copious hematochezia, caused by a Salmonella enteritidis infection.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702140
|
oai_dc
|
The Use of Radionuclide Salivagram and Videofluoroscopic Swallow Study in the Evaluation of Aspiration Pneumonia in Children
|
The Use of Radionuclide Salivagram and Videofluoroscopic Swallow Study in the Evaluation of Aspiration Pneumonia in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Hee Gyung Lee(Ulsan University); Kyung Mo Kim(Ulsan University); Seak Hee Oh(Ulsan University); Yeoun Joo Lee(Ulsan University); Jae Seung Kim(Ulsan University); Kyoung Hyo Choi(Ulsan University); Young Ah Cho(Ulsan University)"
] |
Purpose: To compare the abilities of radionuclide salivagrams (RS) and videofluoroscopic swallow studies (VFSS) to diagnose aspiration in children with aspiration pneumonia. Methods: The records of children who were referred to the Asan Medical Center between April, 2006 and April, 2012 and who underwent both VFSS and RS to evaluate their recurrent aspiration pneumonia were reviewed (n=67). The aspiration positivity rates of the two tests were determined. The agreement between the tests was assessed by using the kappa statistic.
Results: VFSS was more frequently positive (n=26, 39%) than RS (n=23, 34%) (p=0.68). In the 11 children who repeat two test, Repeated examination increased positive rate in each tests (n=11), repeated RS (54%, p=1) is more frequent positive than repeated VFSS (46%, p=0.37). If a cumulative positive test had been defined as at least one positive result, the positive rate of two test was 56% (p＜0.05). There was a fair agreement between RS and VFSS (kappa=0.26). Conclusion: The RS and VFSS positivity rates in children with aspiration pneumonia were similar but there was fair agreement between the two tests. This result suggests that these investigations to demonstrate aspiration are not interchangeable but complementary.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702317
|
oai_dc
|
Leptin, Neuropeptide Y and Islet Amyloid Polypeptide Levels in Obese Children
|
Leptin, Neuropeptide Y and Islet Amyloid Polypeptide Levels in Obese Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Min Seon Choi(Chosun University); 김은영(조선대학교); Soo Hee Jee(Chosun University); Kyung Rae Moon(Chosun University)"
] |
Purpose: The aim of this study was to compare serum leptin, neuropeptide Y (NPY), and islet amyloid polypeptide (amylin) levels in obese and normal weight children, and to investigate their correlations with anthropometric parameters and metabolic bio-marker levels.
Methods: Body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, and serum insulin, leptin, NPY, and amylin levels were measured in 56 children (24 obese children and 32 non-obese controls). Homeostatic model assessment-insulin resistance (HOMA-IR) values were calculated and the relationships between anthropometric variables, metabolic biomarkers, and diet-regulating factors (leptin, NPY, and amylin levels) were examined.
Results: BMI, hip circumference, waist circumference, and systolic and diastolic pressure were significantly higher in the obese group than in the non-obese group (p＜0.0001). Total cholesterol, triglyceride, low-density lipoprotein -cholesterol, glucose, and insulin levels were also significantly higher in the obese group (p＜0.05). On the other hand, high-density lipoprotein-cholesterol levels were higher in the non-obese group , but this was not significant. Serum leptin, NPY, and amylin levels were significantly higher in the obese group (p＜0.05). Furthermore, in the obese group, leptin levels were found to be significantly correlated with BMI (r=0.379, p=0.043), and NPY levels (r=0.377, p=0.044), and amylin levels were found to be significantly correlated with insulin levels (r=0.400, p=0.048), and HOMA-IR (r=0.459, p=0.028).
Conclusion: Metabolic risk factor alterations are present in obese children, and these children show abnormalities in the diet regulatory system caused by leptin, NPY, and amylin resistance. Of particular note, amylin was found to be positively correlated with insulin resistance.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702325
|
oai_dc
|
A Clinical Study of the Relationship between Obesity and Pubertal Development in Girls
|
A Clinical Study of the Relationship between Obesity and Pubertal Development in Girls
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Hui Kwon Kim(한림대학교); Phil Soo Oh(한림대학교); Jong Yoon Lee(한림대학교); 배은주(한림대학교); 박원일(한림대학교); 이홍진(한림대학교)"
] |
Purpose: Recently, public interest in obesity and earlier pubertal development has been increasing. The purpose of this study was to analyze the relationship between obesity and pubertal development in girls.
Methods: A total of 158 girls presenting with earlier pubertal development from July 2008 to June 2010 were included in the study. Their mean age was 8.27±1.3 years and the mean bone age advancement was 1.86±0.3 years.
Results: Based on weight-for-height percentiles, their obesity rate was 9.2% and overweight rate was 15.8%. However, for body mass index (BMI), the result was a bit different; with an obesity rate of 13.2% and overweight rate of 24.3%. About 40% of the girls had a family history of early maturation. Among them, 25.7% had a maternal history, 4.6% paternal and 7.2% both. However, 60% of them had no family history. We then classified these girls into families with one son and one daughter, and those with two daughters. In one-son/one-daughter families, 69.3% were the first children and 30.7% were second. In two-daughter families, 65.3% were the first and 34.7% were second. We found that 67.5% had a history of taking herbal medicine. Conclusion: The obesity and overweight rates in girls with earlier pubertal development were higher than those of normal girls, but with a small discrepancy between weight-for-height percentile and BMI-based results. Furthermore, taking herbal medicine seems to be a potential factor for earlier pubertal development in Korea.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702114
|
oai_dc
|
Micronutrient Deficiency Syndrome: Zinc, Copper and Selenium
|
Micronutrient Deficiency Syndrome: Zinc, Copper and Selenium
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이지현(한림대학교)"
] |
Nutrients are defined as not only having nutritive values of participating in the metabolism and building the structures of cells but also being safe for human body. Nutrients are divided into two types, macronutrient and micronutrient, according to the proportion of the human body. Commonly, micronutrients include trace elements (trace mineral) and vitamins (complex organic molecules). It is difficult to demonstrate micronutrient deficiency because the symptoms are varied and laboratory analyses are limited. Since parenteral nutrition became an established therapy, micronutrient deficiency syndromes are being identified more frequently and emphasize the importance of a complete nutritional support. In this article, we review various specific trace element deficiency states such as zinc, copper, and selenium and briefly discuss the use of dietary supplements.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702342
|
oai_dc
|
Small Bowel Obstruction Caused by an Aberrant Congenital Band in a Child
|
Small Bowel Obstruction Caused by an Aberrant Congenital Band in a Child
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Min Ha Kwak(Dongguk University); 김애숙(동국대학교); Ji Hae Kang(Dongguk University); 최성민(동국대학교); 김두권(동국대학교); 이동석(동국대학교); 하동엽(동국대학교); 김성우(동국대학교)"
] |
Small bowel obstruction due to congenital band is not only rare in children, but also difficult to diagnose, because common symptoms such as vomiting and abdominal pain are observed in patients. In order to prevent a fatal result, an anomalous congenital band should be considered in the discriminative diagnosis of intestinal obstruction in children who have no previous experience of operation or intraperitoneal inflammation. This report presents a 4-year-old boy who was admitted with abdominal pain and nonbilious vomiting for a day. The initial suspicion was for acute gastroenteritis. However, after further investigation and performance of surgery, the intestinal obstruction associated with a congenital band was confirmed. No recurrence was observed during the 8-month follow-up period. Thus early confirmation based on radiologic study is a crucial factor for the diagnosis of small bowel obstruction caused by a congenital band.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001702107
|
oai_dc
|
Recent Updates on Vitamin D and Pediatric Gastrointestinal Diseases
|
Recent Updates on Vitamin D and Pediatric Gastrointestinal Diseases
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"서지현(경상대학교); 장주영(서울대학교); Ji Sook Park(Gyeongsang National University); 박찬후(경상대학교); 윤희상(경상대학교)"
] |
The clinical importance of vitamin D has been recently highlighted, due to non-skeletal effects of vitamin D and the fact that vitamin D receptors are observed in many kinds of cells. Vitamin D deficiency or insufficiency results in the development of gastrointestinal diseases, including obesity, hepatitis B, chronic hepatitis C, and inflammatory bowel disease in children. The prevalence of vitamin D insufficiency in 188 Korean adolescents, aged 12-13 years, was 98.9% for boys and 100% for girls. This article reviews recent publications, regarding vitamin D deficiency and childhood gastrointestinal diseases, and introduces new treatment and prevention guidelines for vitamin D deficiency.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001672091
|
oai_dc
|
How to Manage the Pediatric Nutritional Support Team: Updates
|
How to Manage the Pediatric Nutritional Support Team: Updates
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"양혜란(서울대학교)"
] |
Pediatric patients in hospital are at risk of malnutrition at admission and even during their hospitalization. Although the concept of nutritional support team (NST) was introduced to hospitals for optimal nutritional care since 1960s and the benefits of pediatric NST have been proven by many studies and reports in terms of patient clinical outcome and cost saving, the pediatric NST is not widespread yet. The pediatric NST composed of pediatricians, dieticians, pharmacist, and nutrition support nurses as core members dedicated to nutritional care in children should be independent of central NST or other disciplines, but closely cooperate with other teams in hospitals. There is no doubt that a multidisciplinary NST is an effective way to provide appropriate nutritional support to an individual patient. Therefore, the implementation of the pediatric NST in hospitals should be recommended to provide optimum nutritional support including enteral tube feeding and parenteral nutrition and to assess pediatric patients at risk of malnutrition.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672082
|
oai_dc
|
Strategy to Overcome Drug Resistance That Develops during Treatment of Chronic Hepatitis B in Children
|
Strategy to Overcome Drug Resistance That Develops during Treatment of Chronic Hepatitis B in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Suk Jin Hong(Kyungpook National University); Byung-Ho Choe(Kyungpook National University)"
] |
Development of antiviral resistance to lamivudine is the most important factor for the treatment failure. It is necessary to establish proper guidelines to overcome drug resistance for children with chronic hepatitis B. Primary treatment with lamivudine should be considered if patients are in immune-clearance phase and have persistently elevated ALT levels more than twice the upper limit of normal value. Before initiating the therapy, careful consideration of the patient’s status is required to exclude abnormal liver function tests due to other causes. The treatment option should be carefully decided to suppress the viral replication effectively. To obtain good compliance, clinicians should educate patients and their parents. Appropriate monitoring for virologic breakthrough and genotypic resistance is important in deciding to change the treatment plan. Sequential monotherapy should be avoided and a combination of drugs in other categories is recommended. New antiviral agents, such as entecavir and tenofovir, which have high potency and high genetic barrier, are soon expected to be available for use with children.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672106
|
oai_dc
|
Cytomegalovirus Infection in Infantile Hepatitis
|
Cytomegalovirus Infection in Infantile Hepatitis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"나소영(동국대학교)"
] |
Purpose: The aims of this study was to compare and evaluate the clinical characteristics, laboratory data, and prognosis for infants under age 1 year with CMV hepatitis and those with viral hepatitis of unknown etiology. Methods: A retrospective study was conducted of infants under age 1 year who were admitted with acute hepatitis. The exclusion criteria consisted of: autoimmune, genetic, metabolic, toxic, HAV, HBV, HCV, toxoplasma, rubella, herpes simplex, and Epstein‐Barr virus. The 30 patients included were divided into two groups based on markers for CMV (IgM anti‐CMV, CMV PCR in urine, CMV culture in urine). Results: The median age of patients (n=15) was 2.8 months. No other organ involvement was detected in any patient. Peak serum total bilirubin levels (n=4) ranged from 2.6 to 6.7 mg/dL. Peak serum ALT levels ranged from 51 to 1,581 IU/L. The duration of ALT elevation ranged from 1.5 weeks to 26 weeks (median 9 weeks). All had recovered in full without ganciclovir; there were no cases of hearing loss. The median age of controls (n=15) was 2.5 months. Peak serum total bilirubin levels (n=4) ranged from 1.6 to 9.1 mg/dL. Peak serum ALT levels ranged from 26 to 1,794 IU/L. No significant differences were observed between both groups regarding the peak serum ALT levels, peak serum total bilirubin levels, duration of hyperbilirubinemia and ALT elevation. Conclusion: Although it was not possible to differentiate congenital infection with perinatal infection in this study, the prognosis of patients with CMV hepatitis without other organ involvement was good without ganciclovir treatment.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672110
|
oai_dc
|
A Case of Congenital Paraesophageal Hiatal Hernia in Infancy
|
A Case of Congenital Paraesophageal Hiatal Hernia in Infancy
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Won-Nyung Jang(Hanil General Hospital); Sang-Hee Cho(Hanil General Hospital); In-Su Park(Hanil General Hospital); Kwi-Won Park(Seoul National University); Seon-Young Yoo(Hanil General Hospital); Jin Lee(Hanil General Hospital)"
] |
Esophageal hiatal hernia is the hernia of a part of or the whole of stomach to posterior mediastinum through esophageal hiatus. Esophageal hiatal hernia can be classified as sliding hiatal hernia (type I), paraesophageal (type II), combined sliding and paraesophageal (type III), and complex paraesophageal (type IV). Type III and IV are clinically classified as paraesophageal hernia. The authors by chance found cystic mass filled with air in the lower lobe of the right lung during the treatment of mycoplasma pneumonia of 10 month-old patient. It was found to be paraesophageal hernia on the chest computed tomography and treated with the operation. As complex paraesophageal hernia is not usual among infants, the authors report it here with literature review.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672128
|
oai_dc
|
Benign Recurrent Intrahepatic Cholestasis with a Single Heterozygote Mutation in the ATP8B1 Gene
|
Benign Recurrent Intrahepatic Cholestasis with a Single Heterozygote Mutation in the ATP8B1 Gene
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Yun Seok Lee(Sungkyunkwan University); 최연호(삼성서울병원); 김미진(충남대학교 의과대학의학연구소); Chang Seok Ki(Sungkyunkwan University); Yoo Min Lee(Sungkyunkwan University); Yoon Lee(Sungkyunkwan University)"
] |
Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by multiple recurrent episodes of severe cholestatic jaundice without obstruction of extrahepatic bile duct. We present the case of a 7-year-old boy with BRIC confirmed by mutation analysis in the ATP8B1 gene and typical clinical manifestation. Despite inheritance of BRIC, we detected a mutation on only one allele. To our knowledge, this is the first report of BRIC with a confirmed single heterozygote novel mutation in the ATP8B1 gene in Korea.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672103
|
oai_dc
|
Comparison of Four Commercial ELISA Kits and In-House Immunoblotting for Diagnosis of Helicobacter pylori Infection
|
Comparison of Four Commercial ELISA Kits and In-House Immunoblotting for Diagnosis of Helicobacter pylori Infection
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Hoar Lim Jeong(Gyeongsang National University); 윤희상(경상대학교); Yang‐Sook Jung(Gyeongsang National University); 전진수(경상대학교); 염정숙(경상대학교); Ji Sook Park(Gyeongsang National University); 서지현(경상대학교); 임재영(경상대학교); 박찬후(경상대학교); 우향옥(경상대학교); 고경혁(경상대학교); 백승철(경상대학교); 이우곤(경상대학교); 조명제(경상대학교); 이광호(경상대학교)"
] |
Purpose: Commercial enzyme-linked immunosorbent assay (ELISA) kits have been considered less reliable for children than for adults. The aim of this study was to compare four ELISA kits and in-house immunoblotting based on the analysis of anti-H. pylori -IgG antibody reactivity. Methods: A total of 399 serum samples were collected at the GNU Hospital during 1998–1999. All sera were tested using ELISA and immunoblotting. Statistically significant differences were determined by the χ^2 test.
Results: The overall seropositivity rates using GAP IgG, Genedia IgG, HM-CAP, Pyloriset EIA-G, and immunoblotting were 13.0%, 25.1%, 18.3%, 15.8%, and 62.9%, respectively. Immunoblotting showed a higher seropositivity rate than did all four ELISA kits in all age groups. Genedia IgG had the highest seropositivity among the ELISA kits. The seropositivity rate for children aged 13 to 18 months was lowest, and that of children aged 15 years was highest (90.0%). The seropositivity rate for children aged 7 months to 5 years was significantly lower than that for children aged 6 to 15 years among the four ELISA kits (p＜0.0001) and immunoblotting (p=0.02).
Conclusion: Immunoblotting is the most sensitive test for detection of anti-Helicobacter pylori IgG antibodies among the serological tests in this study. These results emphasize the need for standardization when commercial ELISA tests are used in different nations or in young age groups. Immunoblotting could be a suitable noninvasive assay for serodiagnosis and seroepidemiologic study of H. pylori infection in Korean children.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672124
|
oai_dc
|
A Case of Idiopathic Congenital Neonatal Cholestasis in a Patient with Down Syndrome
|
A Case of Idiopathic Congenital Neonatal Cholestasis in a Patient with Down Syndrome
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Tae-eon Huh(Gyeongsang National University Hospital); Ji Sook Park(Gyeongsang National University Hospital); Hyun Jeong Do(Gyeongsang National University Hospital); Jung Sook Yeom(Gyeongsang National University Hospital); 박은실(경상대학교); 서지현(경상대학교); 임재영(경상대학교); 박찬후(경상대학교); 우향옥(경상대학교); 윤희상(경상대학교)"
] |
Down syndrome is a rare cause of neonatal cholestasis. Neonatal cholestasis in a patient with Down syndrome is usually associated with severe liver diseases, such as neonatal hemochromatosis, myeloproliferative disorder and intrahepatic bile duct paucity. We experienced a case of idiopathic neonatal cholestasis in a patient with Down syndrome, which resolved spontaneously.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672086
|
oai_dc
|
The Role of Inflammatory Mediators in the Pathogenesis of Nonalcoholic Fatty Liver Disease
|
The Role of Inflammatory Mediators in the Pathogenesis of Nonalcoholic Fatty Liver Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김준성(울산대학교)"
] |
With a markedly increased prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) now becomes the most common cause of chronic liver disease in both adults and children. The etiology and pathogenesis of NAFLD are multifactorial and remain incompletely understood. According to the “two-hit” theory, inflammatory cytokines and adipokines are activated by oxidative stress and they are involved in insulin resistance, necroinflammatory steatohepatitis and fibrosis. This review discusses the latest updates on the role of some of important inflammatory adipokines and cytokines in the pathogenesis of NAFLD with an emphasis on their potential therapeutic implications.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672114
|
oai_dc
|
Endoscopic Hemostasis for Bleeding Gastric Ulcer Caused by Ibuprofen in a 16-month-old Infant
|
Endoscopic Hemostasis for Bleeding Gastric Ulcer Caused by Ibuprofen in a 16-month-old Infant
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"나소영(동국대학교)"
] |
Gastric ulcers are rare in children and are typically seen in cases of Helicobacter pylori (H. pylori) infection, non-steroidal anti-inflammatory drugs (NSAIDs) use, and critical illnesses such as sepsis. The risk of a bleeding ulcer due to use of NSAIDs is dependent on the dose, duration, and the individual NSAIDs, but the bleeding may occur soon after the initiation of NSAID therapy. An experience is described of a 16-month-old infant with a bleeding gastric ulcer after taking the usual dosage of ibuprofen for 3 days. The infant was also successfully treated with endoscopic hemostasis. Even a small amount of ibuprofen may be associated with bleeding gastric ulcers in infant.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001672119
|
oai_dc
|
A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis
|
A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Yun Ji Kim(Sungkyunkwan University); 정혜림(성균관대학교); Seung Lok Ryu(Sungkyunkwan University); Jae Won Shim(Sungkyunkwan University); Duk Soo Kim(Sungkyunkwan University); 심정연(성균관대학교); 박문수(성균관대학교)"
] |
Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia dulcis for about 1 year prior to presentation. A diagnosis of toxic hepatitis was made based on his history, laboratory data, viral markers, ultrasonography, and biopsied liver tissue. We administered supportive management for acute fulminant hepatitis but his symptoms and liver function progressed. He was transferred to another hospital for further evaluation and consideration for liver transplantation. Because acute liver failure due to herbs or dietary supplement taken for a long time is often fetal, it is important to make early diagnosis and stop taking the drug as soon as drug induced liver injury is suspected.
|
소아과학
| null |
http://dx.doi.org/
|
kci_detailed_000002.xml
|
||
ART001731955
|
oai_dc
|
Juvenile Polyp and Colonoscopic Polypectomy in Childhood
|
Juvenile Polyp and Colonoscopic Polypectomy in Childhood
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Byung Gee Lee(Good Gang-An Hospital); Sung Hyun Shin(Pusan National University); Young Ah Lee(Good Gang-An Hospital); Joo Hee Wi(Pusan National University); Yeoun Joo Lee(Pusan National University); 박재홍(부산대학교)"
] |
Purpose: This study aimed to evaluate the clinical features of juvenile polyp and the usefulness of polypectomy with entire colonoscopy in children.
Methods: We retrospectively reviewed the medical records of 83 children who were diagnosed with having juvenile polyps.
Results: The mean age of the patients was 6.5±3.7 (range 1.3-14.5 years) years. The male to female ratio was 2.1 : 1. Eighty one patients (97.6%) had hematochezia, of which the observed characteristics included red stool (74.1%), blood on wipe (13.6%). The time interval between the 1st episode of hematochezia and colonoscopy was 8.9±20.4 (ranged 0.1-48.0) months. The most proximal regions of colonoscopic approach were terminal ileum (96.4%). Sixty three patients (75.9%) had a solitary polyp and 20 patients (24.1%) had multiple polyps. The sites of the polyps were rectum (61.4%), sigmoid colon (23.5%). Eighteen polyps (15.1%) were found more proximal locations than rectosigmoid. The polyp size ranged from 0.3 to 5 cm. After the polypectomy, hematochezia recurred in 9 patients. Endoscopic hemostasis was performed in 2 patients due to severe bleeding. All procedures were carried out without using general anesthesia.
Conclusion: Juvenile polyp occurred in a wide range locations and had variable sizes and numbers, suggesting that colonoscopy on the entire colon is necessary. Colonoscopic polypectomy is a simple and useful therapeutic method in children with juvenile polyp.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731913
|
oai_dc
|
Diagnosis of Wilson Disease in Young Children: Molecular Genetic Testing and a Paradigm Shift from the Laboratory Diagnosis
|
Diagnosis of Wilson Disease in Young Children: Molecular Genetic Testing and a Paradigm Shift from the Laboratory Diagnosis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Jeong Kee Seo(Seoul National University)"
] |
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism that results in accumulation of copper primarily in the liver, brain and cornea. Mutations in the WD gene, ATP7B, cause failure of copper excretion from hepatocyte into bile and a defective synthesis of ceruloplasmin. More than 500 mutations are now recognized, scattered throughout the ATP7B gene. Since WD has protean clinical presentations, awareness of WD in clinical practice is important for the early diagnosis and prevention of accumulated copper toxicity. Molecular genetic testing is playing an increasingly important role in the diagnosis of WD in uncertain cases and family screening. Siblings should be screened for WD once an index case has been diagnosed. Discrimination of heterozygotes from asymptomatic patients is essential to avoid inappropriate lifelong therapy for heterozygotes. Genetic testing, either by haplotype analysis or by mutation analysis, is the only definite solution for differentiating heterozygote carriers from affected asymptomatic patients. Routine genetic testing, because of the multitude of documented mutations, has been thought to be impractical until recently. However, genetic testing is now being more actively applied to the diagnosis of WD, particularly in young children in whom conventional biochemical diagnosis has much limitation and only genetic testing is able to confirm WD. Because advancement of modern biochemical technology now allows more rapid, easier, and less expensive mutation detection, direct DNA sequencing could be actively considered as the primary mode of diagnostic investigation rather than a supplementary test to the conventional biochemical tests. This review will focus on the recent advancement of molecular genetics and genetic diagnosis of WD in very young children on the basis of research data of the Seoul National University Children’s Hospital and recent literature.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731916
|
oai_dc
|
Community Management of Acute Malnutrition in the Developing World
|
Community Management of Acute Malnutrition in the Developing World
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Se-Eun Park(World Vision Eastern Africa Regional Office); Sungtae Kim(World Vision Eastern Africa Regional Office); Cyprian Ouma(World Vision Eastern Africa Regional Office); Mesfin Loha(World Vision Eastern Africa Regional Office); Thomas F Wierzba(The International Vaccine Institute); Nam Seon Beck(The International Vaccine Institute)"
] |
Globally, acute malnutrition triggers more than 50% of childhood mortality in children under 5 years old, which implies that about 3.5 million children die of malnutrition each year. Prior to the advent of ready-to-use therapeutic food (RUTF), the management of acute malnutrition was limited to hospitals, resulting in low coverage rates with high mortality, as malnourished cases were indentified at later stages often plagued with complications. However, current availability of RUTF has enabled malnourished children to be treated at communities. Further, because RUTF is dehydrated and sealed, it has the added advantage of a lower risk of bacterial contamination, thereby prolonging its storage life at room temperature. Recent data indicate that Community Management of Acute Malnutrition (CMAM) is as cost effective as other high-impact public health measures such as oral rehydration therapy for acute diarrheal diseases, vitamin A supplementation, and antibiotic treatment for acute respiratory infections. Despite the high efficacy of CMAM programs, CMAM still draws insufficient attention for global implementation, suggesting that CMAM programs should be integrated into local or regional routine health systems. Knowledge gaps requiring further research include: the definition of practical screening criteria for malnourished children at communities, the need for systematic antibiotic therapy during malnutrition treatment, and the dietary management of severe malnutrition in children below 6 months of age.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731954
|
oai_dc
|
Efficacy of Early Infliximab Treatment for Pediatric Crohn’s Disease: A Three-year Follow-up
|
Efficacy of Early Infliximab Treatment for Pediatric Crohn’s Disease: A Three-year Follow-up
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Yun Seok Lee(Sungkyunkwan University); Sang Hun Baek(Sungkyunkwan University); 김미진(충남대학교 의과대학의학연구소); 이유민(순천향대학교); Yoon Lee(Sungkyunkwan University); Yon Ho Choe(Sungkyunkwan University)"
] |
Purpose: To investigate the efficacy of early infliximab use and to follow the progress of pediatric cases of Crohn’s disease for 3 years.
Methods: We reviewed the medical records of 28 pediatric patients who had been treated with infliximab for Crohn’s disease. Eighteen patients (the ‘top-down’ group) received infliximab and azathioprine for induction and maintenance therapy for the first year, and then were treated with azathioprine for 2 additional years. Ten patients who were refractory to conventional therapy were categorized in the ‘step-up’ group. All patients were followed for at least 36 months. Treatment efficacy was assessed by the relapse rate using the pediatric Crohn’s disease activity index (PCDAI) score in each group at 12, 24, and 36 months. Blood samples were available from 10 patients, and were used to assess antibody to infliximab (ATI).
Results: The relapse rate in ‘top-down’ group was lower than that in ‘step-up’ group at 1, 2, and 3 years. But, just the relapse rate at the 2 years was significantly different. At 3 years, the relapse rate according to different characteristic variables (sex, age at diagnosis, involvement, PCDAI at diagnosis) was not significantly different. Only one patient treated with infliximab had an adverse event, consisting of dyspnea and tachycardia. ATI was not detected in the blood samples from 10 patients.
Conclusion: Early induction with infliximab at diagnosis (‘top-down’ therapy) is effective for reducing the relapse rate compared to conventional therapies in pediatric Crohn’s disease possibly for up to 3 years.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731950
|
oai_dc
|
Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy for Helicobacter pylori Eradication in Korean Children
|
Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy for Helicobacter pylori Eradication in Korean Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Jeana Hong(Kangwon National University); 양혜란(서울대학교)"
] |
Purpose: The aim of this study was to assess and compare the efficacies of proton pump inhibitor-based triple therapy and bismuth-based quadruple therapy as first-line treatments for Helicobacter pylori eradication in Korean children.
Methods: We retrospectively reviewed the data of children who had been diagnosed with H. pylori infection at the Seoul National University Bundang Hospital from March 2004 to August 2012. The patients were randomly assigned to receive either triple therapy consisting of omeprazole, amoxicillin, and clarithromycin for 2 weeks (OAC group) or quadruple therapy comprising omeprazole, amoxicillin, metronidazole, and bismuth salts for 1 week (OAMB group). The patients were evaluated for eradication of H. pylori infection at 4 weeks after the completion of the treatment.
Results: Of the 129 children enrolled in this study, 118 (91.5%) were included in the final analysis. The eradication rates in OAC and OAMB groups were 67.7% (42/62) and 83.9% (47/56), respectively, which were significantly different between the 2 treatment groups (p=0.041). The eradication rates in the OAMB group during the periods 2004-2006, 2007-2009, and 2010-2012 were superior to those in the OAC group.
Conclusion: This study indicated that the 1-week bismuth-based quadruple therapy, compared with the standard 2-week triple therapy, was significantly more successful in eradicating H. pylori infection in Korean children.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731947
|
oai_dc
|
Gastro-Esophageal Reflux Disease in Healthy Older Children and Adolescents
|
Gastro-Esophageal Reflux Disease in Healthy Older Children and Adolescents
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"박기영(울산대학교); Soo Hee Chang(Bundang Jesaeng General Hospital)"
] |
Gastro-esophageal reflux disease (GERD) in otherwise healthy older children and adolescents is commonly encountered in pediatric clinics and poses a complex treatment problem involving changes of diets and lifestyle. After an initial history taking and a physical examination, typical symptoms of GERD in older children and adolescenct are initially treated with the trials of acid suppressants. With an increase of severe cases, more and more GERD children have been evaluated with endoscopy, which helps to delineate an erosive esophagitis from a non-erosive reflux disease as they are presumed to have different pathogenesis. For the pediatric patients without a significant underlying disease, a reflux esophagitis can be treated adequately with acid suppressants. Recently, the rapid increase of children who are taking anti-reflux medication has brought up a serious alarm among pediatricians. Some at risk pediatric patients with recurrent and/or chronic GERD have been linked to adulthood GERD. In this paper, pediatric GERD with and without erosive esophagitis was reviewed along with treatment options and issues specifically for the otherwise healthy older children and adolescents in the primary clinics or the secondary hospitals.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731958
|
oai_dc
|
The Efficacy of Pharmacological Treatment in Pediatric Nonalcoholic Fatty Liver Disease
|
The Efficacy of Pharmacological Treatment in Pediatric Nonalcoholic Fatty Liver Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Taeshik Cho(Hanyang University); 김용주(한양대학교); 백승삼(한양대학교)"
] |
Purpose: With growing number of obese children, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric population is increasing. Nonalcoholic steatohepatitis (NASH) is a severe form of NAFLD, and can cause morbid complications. It is important to identify patients in order to grade pathologic severities and treat those children who possibly have NASH. This study was performed to evaluate whether the pharmacological therapy is also effective as well as the body weight reduction in pediatric NAFLD. Methods: Among the 52 children presenting with obesity and hepatopathy, NAFLD was diagnosed through liver biopsy in 29 children, who were 7 to 14 years of age, from January 2006 to December 2011. The patients were advised to reduce their body weight through diverse methods. Medication with Ursodeoxycholic acid (UDCA) and vitamin E was performed in children whose liver functions did not improve or their weight reductions were not successful. The therapeutic effects were monitored and assessed via the biochemical profiles and the physical measurements. Results: The therapy of vitamin E and UDCA combined with body mass index (BMI) reduction showed significantly higher rate of improvement in clinical profiles, which could be seen in data of aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT ratio, alkaline phosphatase, total bilirubin and γ-glutamyl transpeptidase. Children whose BMI were successfully reduced showed favorable clinical improvements without any medication, but those without BMI reduction did not show any improvement despite medications. Conclusion: This study showed that the first line of therapy should be the BMI reduction in NAFLD and drug therapy combined with BMI reduction could have additive therapeutic effect in children with NAFLD.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731949
|
oai_dc
|
How to Do in Persistent Diarrhea of Children?: Concepts and Treatments of Chronic Diarrhea
|
How to Do in Persistent Diarrhea of Children?: Concepts and Treatments of Chronic Diarrhea
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이건송(단국대학교); Dong Soo Kang(Dankook University); 유지숙(단국대학교 의과대학 소아과학교실); 장영표(단국대학교); Woo Sung Park(Dankook University)"
] |
Chronic diarrhea is defined as passing watery stools that lasts for more than 2 weeks. Persistent diarrhea belongs to chronic diarrhea and is a chronic episode of diarrhea of infectious etiology. The etiology of chronic diarrhea is varied. It is important to consider the child’s age and clinical manifestations with alarm signals for an application of proper treatments to children with chronic diarrhea. Vicious cycle is present in chronic diarrhea and nutritional rehabilitation can break the vicious cycle of chronic diarrhea and is one of the main one thing among treatments. We should know the exact concept of chronic diarrhea and provide appropriate treatments according to etiologies of chronic diarrhea.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731962
|
oai_dc
|
A Case of Small Bowel Ulcer Associated with Helicobacter pylori
|
A Case of Small Bowel Ulcer Associated with Helicobacter pylori
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Eun Young Kim(Hallym University); 이지현(한림대학교); Saet Byul Woo(Hallym University); 이정원(한림대학교); Kon Hee Lee(Hallym University); Su Rin Shin(Hallym University); Jee Hyun Lee(Hallym University)"
] |
The etiology of peptic ulcer disease in children may be primary, associated with Helicobacter pylori infection, or secondary, relied on underlying disease. Ulcerative lesions by H. pylori are mainly distributed in the duodenal bulb and they are rare below the ampulla of Vater because H. pylori growth is inhibited by bile juice. In this reason, there are only some restrictive reports presented small bowel ulcer associated H. pylori. We found multiple small bowel ulcerative lesions associated with H. pylori in an 11-year-old girl without any systemic disease while performing esophagogastroenteroscopy to the level of the proximal jejunum for differentiating bezoar. The abdominal pain improved after the patient was administered H. pylori eradication therapy. Because a small bowel ulcer associated with H. pylori has rarely been reported, we report it here with literature review.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001731965
|
oai_dc
|
Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease
|
Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Geum-Chae-Won Yi(Keimyung University); Ka-Hyun Yoon(Keimyung University); 황진복(계명대학교)"
] |
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590308
|
oai_dc
|
다문화 가정의 이유기 보충식 현황과 외국인 어머니의 인식 연구: 한국인 어머니를 대상으로 한 연구와 비교해서
|
Current Complementary Feeding and Maternal Nutritional Knowledge in Multicultural Family: Compared to the Korean Survey
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"양누리(전주예수병원); 김혜실(전주예수병원); 김미경(전주예수병원)"
] |
Purpose: To evaluate current complementary feeding and maternal nutritional knowledge of a multicultural family in Korea.
Methods: Foreign mothers of babies aged 9∼24 months, who visited pediatric clinics or attended a meeting on a multicultural family party between December 2010 and April 2011, were asked to fill out questionnaires. Data from 146 questionnaires were analyzed.
Results: Complementary food was introduced at 4∼7 months in 78% of babies. The following were the sources of information on complementary feeding: friends (34%), relatives (27%), books/magazines (19%), multicultural family educational support center (8%), mass media (4%), and hospitals (3%). The cases of complementary food introduction after 8 months (21% vs. 10%, p＜0.001), initial use of commercial food (26% vs. 6%, P＜0.001) and initial use of bottle feeding (15% vs. 3%, p＜0.001) were more frequent compared to the 2009 Korean survey. Mothers agreeing with the following suggestions were relatively fewer: feeding minced meat from 6∼7 months (61%), No mixed cereal powder as complementary food (61%), feeding egg white after 12 months (63%), no adding salt or sugar to the complementary food (64%), bottle weaning before 15∼18 months (66%) and considering formula better than soy milk (68%).
Conclusion: Complementary feeding practices of multicultural families showed many points of improvement compared with the 2009 Korean survey. Pediatricians should make more of an effort to consult with families of multicultural infants about nutrition and complementary feeding. Also, the government and the pediatrics academy need to institute policies to support the nutrition of multicultural infants. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 286∼298)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590267
|
oai_dc
|
소아청소년과 의사에 의한 복부 초음파 검사의 유용성과 함정
|
Usefulness and Pitfall of Abdominal Ultrasonographic Examinationby a Pediatrician in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"박재홍(부산대학교)"
] |
Ultrasonographic examination plays an important role in non-invasive and prompt screening examinations in detecting abdominal diseases. In this review, the author's experience of the usefulness and pitfalls of ultrasonographic examinations in children with gastrointestinal symptoms is presented. A total of 1,000 cases of children who underwent ultrasonographic evaluation in the Department of Pediatrics, Pusan National University Hospital were reviewed. The main causes leading to ultrasonographic evaluation were abdominal pain (43.9%), vomiting (17.3%), elevated liver enzymes (11.8%), and jaundice (9.8%). Abnormal ultrasonographic findings accounted for 57.9% of cases. The major abnormal findings were mesenteric lymphadenitis (29.2%), fatty liver (12.1%), hepatitis (6.4%), hepatosplenomegaly (6.2%), and acute appendicitis (4.8%). The major findings in children with abdominal pain were mesenteric lymphadenitis (32.6%), intussusception (2.7%), and acute appendicitis (2.7%). The major findings in children with vomiting were mesenteric lymphadenitis (12.7%), hypertrophic pyloric stenosis (10.4%), acute appendicitis (3.5%). The major ultrasonographic findings in children with urinary tract diseases were hydronephrosis (45.4%), urolithiasis (21.5%) and cystic renal disease (18.1%). Ultrasonography performed by pediatricians is advantageous because pediatricians are able to perform the procedure with clinical information at the right time. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 245∼250)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590282
|
oai_dc
|
소아 크론병의 장 점막 조직에서 FOXP3+T세포와 TGF-β1 발현에 관한 연구
|
FOXP3+T Cells and TGF-β1 in Colonic Mucosa of Children with Crohn's Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"길주현(이화여자대학교); 오정은(이화여자대학교); 서정완(이화여자대학교); 조민선(이화여자대학교); 조기영(이화여자대학교); 유은선(이화여자대학교)"
] |
Purpose: Forkhead box protein 3 (FOXP3)+T cells are the major regulatory T cells controlling all aspects of the immune response. Transforming growth factor-β (TGF-β) is a suppressive cytokine which mediates the suppressive action of FOXP3+T cells. The aim of this study was to investigate the role of FOXP3+T cells, TGF-β in colonic mucosa of children with Crohn’s disease (CD).
Methods: Colonic mucosal biopsies were obtained from 10 children with CD (12∼15 years of age) and 11 control (8∼15 years of age). Frequencies of FOXP3+T, CD4+T cells and TGF-β1 expression were examined in the lamina propria (LP) and lymphoid aggregates or follicles (LA/F) by immunohistochemistry, and later evaluated by association with disease activity.
Results: In the LP of CD group, frequencies of FOXP3+T, CD4+T cells, proportion of FOXP3/CD4+T cells and TGF-β1 expression significantly increased compared to the control. In the LA/F of CD group, frequency of FOXP3+T cells, proportion of FOXP3/CD4+T cells and TGF-β1 expression significantly increased compared to the control (p＜0.05). CD4+T cells also increased compared to the control, but this finding was not significant. In the LP and LA/F of CD group, frequency of FOXP3+T cells exhibited positive correlation with CD4+T cells (p＜0.05). In the LP and LA/F of CD group, TGF-β1 expression had positive correlation with CRP, Pediatric Crohn's Disease Activity Index, and negative correlation with hematocrit and albumin (p＜0.05).
Conclusion: Increased frequency of FOXP3+T cells and TGF-β1 expression in colonic mucosa of CD can be interpreted as a compensatory increase towards achieving down-regulation of immune responses. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 258∼268)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590322
|
oai_dc
|
막대자석 14개를 삼킨 12세 자폐아: 위내시경과 대장내시경을 이용한 단계적 배출
|
A Case of Magnet Ingestion in a Child with Autism: Gastro-Colonoscopic Removal without Surgical Complication
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"김주휘(서울대학교); 임미선(서울대학교); 김순철(서울대학교); 이은혜(서울대학교); 고재성(서울대학교); 서정기(서울대학교)"
] |
With the increasing use of magnets in toys, magnet ingestion is becoming a serious problem in children. Two or more magnets may attract across the gastrointestinal tract leading to pressure necrosis, perforation, fistula, volvulus or obstruction. We report a case of a 12-year-old boy with autism who presented with vomiting during seven days due to ingestion of 14 magnetic rods. Under general anesthesia, 5 of 14 magnets were removed from the second portion of the duodenum using a magnetic probe during endoscopy. The remaining magnets were not visible in the duodenum. A plain radiograph taken the next day revealed that the remaining magnets were impacted in the descending-sigmoid junction. One magnet passed spontaneously. However the other 8 magnets did not pass through the junction for 7 days. Five of 8 impacted magnets were removed by a colonoscopic procedure. After 2 hours of colonoscopy, one by one, the remaining three magnets spontaneously passed. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 299∼304)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590298
|
oai_dc
|
소아 만성 B형 간염에서 Hepatitis B Virus Precore와 Core Promoter 및 “a” 결정기의 변이종에 대한 연구
|
Mutations in Hepatitis B Virus Precore, Core Promoter, and “a” Determinant in Children with Chronic Hepatitis B Virus Infection
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"이성수(서울대학교); 장주영(서울대학교); 서정기(서울대학교)"
] |
Purpose: The aim of this study was to determine the prevalence, types of variants, and clinical significance of mutations in precore, core promoter, and “a” determinant mutations in children with chronic hepatitis B virus infection.
Methods: Thirty-one patients with chronic hepatitis B virus infection who visited Seoul National University Children's Hospital in Korea between 2004 and 2005 were enrolled in this study. Serum HBV DNA was amplified by polymerase chain reaction (PCR) and the precore/core promoter and “a” determinant sequences were determined.
Results: Precore mutations were found in 11 of 27 patients (40.7%), and appeared more frequently in the HBeAg-negative group (p＜0.05) compared to the HBeAg-positive group. G1896A was detected most frequently (81.8%). BCP mutations were found in 15 of 27 patients (55.6%) and the TA mutation (A1762T/G1764A) was the most common (86.7%). Mutations in the “a” determinant region were detected in 8 of 28 patients (28.6%), and amino acid changes were detected in 6 of 28 patients (21.4%). Of these mutations, substitutions at amino acid position 126 were found most frequently.
Conclusion: In children with chronic hepatitis B virus infection, the most common mutations were G1896A in the precore region and TA mutation(A1762T/G1764A) in the core promoter region. Substitutions at amino acid position 126 was the most common mutation in the “a” determinant. Precore mutants were found to be significantly higher in HBeAg-negative patients. The high prevalence of mutations in the “a” determinant and low frequency of G145R were characteristic features. These mutations were not significantly associated with other clinical features except for high aminotransferase concentration in the core promoter variant group. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 279∼285)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590289
|
oai_dc
|
염증성 장질환 환자에서 종양괴사인자: 알파의 유전적 다형과 임상상과의 연관성
|
Tumor Necrosis Factor-α Gene Polymorphisms in Korean Children with Inflammatory Bowel Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"조민성(울산대학교); 송승민(울산대학교); 오석희(울산대학교); 이연주(울산대학교); 장주영(울산대학교); 김경모(울산대학교)"
] |
Purpose: The aim of this study was to investigate the existence of TNF-α polymorphisms in Korean children with Crohn’s disease (CD), ulcerative colitis (UC), as compared to healthy controls.
Methods: Blood samples were obtained from 40 patients with CD, 14 patients with UC, and 30 healthy controls. Genotyping for 5 TNF-α polymorphisms (G238A, G308A, C857T, C863A, and T1031C) was performed. The allele frequencies for the inflammatory bowel diseases, CD and UC, were measured in patients with these disease and in healthy controls, and these allele frequencies were compared between the 3 groups. We examined the significant association between polymorphism and disease phenotype, such as location, behavior, perianal disease, and pediatric Crohn’s activity index (PCDAI) in CD.
Results: Based on our findings, the TNF-α allele frequencies of G238A, G308A, C857T, C863A, and T1031C were 3.3, 8.3, 16.7, 16.7, 21.7% in healthy control, 2.5%, 7.5%, 18.8%, 20.0%, 22.5% in CD, 7.1%, 7.1%, 7.1%, 21.4%, 28.6% in UC. They were no statistically significant differences between the 3 groups. There were no associations between genotypes and phenotypes in CD, except a statistically significant higher allele frequency of G238A in ileal type (L1) disease (p=0.010).
Conclusion: Our results indicate that 5 TNF-α polymorphisms do not seem to be associated with susceptibility to inflammatory bowel disease in Korean pediatric patients even though young patients were anticipated to have a stronger genetic affiliation for these diseases than adult patients. We think that further studies are needed to find those genes associated with susceptibility to CD and UC in Korean pediatric patients with inflammatory bowel disease. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 269∼278)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590258
|
oai_dc
|
Functional Abdominal Pain in Children
|
Functional Abdominal Pain in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"고홍(연세대학교)"
] |
Functional abdominal pain (FAP) is one of the most common pain syndromes in childhood and is a functional gastrointestinal disorder (FGID). Recurrent abdominal pain (RAP) is characterized by three or more episodes of abdominal pain that occurover at least 3 months and are severe enough to interfere with activities. It may be caused by many conditions, including inflammatory bowel disease, peptic ulcer, pancreatitis or, functional abdominal pain. The most common clinical manifestation is periumbilical pain related to autonomic and functional symptoms like nausea, vomiting, pallor and other painful conditions like headache and limb pains. RAP requires accurate diagnostic tests to rule out organic causes of pain based on ‘red flag’ sign. Furthermore, to diagnose and classify functional abdominal pain, Rome III criteria were published and updated with multiple discussions of FGIDs. Conventional interventions for RAP include reassurance and general advice, symptom-based pharmacological therapies, and psychological and behavioral treatments. But further research should be conducted to advance our understanding of the multiple factors involved in the pathogenesis of this group of conditions and to provide evidence for its therapeutic benefit. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 222∼231)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590276
|
oai_dc
|
소아의 식도 동전 제거에서 내시경 전에 시도한Foley 카테터의 유용성
|
Feasibility of Foley Catheter Prior to Endoscopy for the Removalof Esophageal Coin in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"강지현(경북대학교); 정혜정(경북대학교); 서진경(경북대학교); 박준석(경북대학교); 박효정(경북대학교); 추미애(경북대학교); 조승만(경북대학교); 최병호(경북대학교)"
] |
Purpose: This study evaluated the efficiency and safety of the Foley catheter for esophageal removal of coins in children, compared to standard endoscopic extraction with respect to success rate, sedation, promptness and cost.
Methods: Twenty four children with coin lodgement in esophagus were managed with either a Foley catheter (n=14) or endoscopic extraction (n=10) from January 2007 through August 2010 at Kyungpook National University Hospital. A retrospective review of medical records and radiological findings was performed.
Results: Of the 14 patients who underwent Foley catheter extraction, successful and complication-free removal was achieved in 10 cases (71.4%). Of the 10 patients who underwent endoscopic extraction, all cases were successful (p=0.114). Sedation rate in the Foley catheter and endoscopic extraction group was 6/14 and 10/10 (p=0.006). The average wait time before the procedure and average hospital charge (US$) were 2.0±1.1 hours and 18.1±13.7 hours, and $113 and $428 for Foley catheter extraction and endoscopic extraction, respectively.
Conclusion: Foley catheter extraction may be tried for the removal of esophageal coins in uncomplicated children. The technique is effective, safe, inexpensive and free of general anesthesia. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 251∼257)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590254
|
oai_dc
|
소아 비알코올 지방간질환의 최신지견
|
Nonalcoholic Fatty Liver Disease in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"서정완(이화여자대학교)"
] |
Obesity is significantly increasing in Korean adolescents and nonalcoholic fatty liver disease (NAFLD) is soon expected to be the most common chronic liver disease in children. The symptoms of NAFLD run a broad spectrum and NAFLD in children can lead to the development of nonalcoholic steatohepatitis, cirrhosis and end-stage liver disease, hepatocellular carcinoma (HCC), and can increases the risk of type 2 diabetes and cardiovascular disease. Definitive diagnosis can be achieved with liver biopsy. However, recent advances have shown alternative methods of screening and following patients with noninvasive biomarkers and radiologic imaging studies. The histopathology differs between children and adults, and the mechanism is expected to differ as well. Several factors, such as genes and environmental stressors work intricately to produce NAFLD. Promising medications have been reported for the management of NAFLD. However, their therapeutic effectiveness has yet to be determined. Dietary and exercise interventions remain the mainstay of treatment. By maintaining an interest in obesity and NALFD in children, NAFLD should be diagnosed early and appropriate lifestyle changes should be counseled and encouraged. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 209∼221)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001590263
|
oai_dc
|
만성 반복성 복통과 상부 위 장관의 기질적 질환:Helicobacter pylori 감염을 중심으로
|
Organic Upper Digestive Diseases in Children with Chronic Abdominal Pain
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"장수희(분당재생병원)"
] |
Organic diseases are prevalent in about 5 to 10% of children with chronic abdominal pain. The most common diseases of the upper digestive tract include gastroesophageal reflux disease (GERD), chronic gastritis with or without Helicobacter pylori (H. pylori), and peptic ulcer. The H. pylori infections acquired during childhood persist lifelong without eradication. Although the majority of H. pylori infected children remain asymptomatic, H. pylori infection may cause various digestive and extra-digestive diseases. There are still debates about a causal relationship between H. pylori-gastritis and abdominal symptoms in the absence of peptic ulcer disease. The number of Korean children infected with antibiotic resistant H. pylori is increasing even though the prevalence decreases after eradication. The choices of rescue therapy are limited in children after eradication failure. Antioxidant supplements with regimens against H. pylori have been tried with limited effects. Here I wanted to review the findings of recent reports on common upper digestive diseases such as GERD, peptic ulcer, and H. pylori infection in children with chronic abdominal pain. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 232∼244)
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001648676
|
oai_dc
|
Biological Therapy for Inflammatory Bowel Disease in Children
|
Biological Therapy for Inflammatory Bowel Disease in Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"나소영(동국대학교); Jung Ok Shim(Korea University Medical Center)"
] |
The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune factors. Biological agents such as anti-tumor necrosis factor (anti-TNF) are widely being used as therapeutic agents. Infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor, has been demonstrated to have an effect in the induction and maintenance of remission in Crohn's disease in children. The effects of biological agents, typified by anti-TNFs, in inflammatory bowel disease in children; the recent concern on the administration of biological agents in combination with immunomodulators; and 'Top-down’ therapy are some of the topics covered in this review.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001648693
|
oai_dc
|
Plasma Real Time-Quantitative Polymerase Chain Reaction of Epstein-Barr Virus in Immunocompetent Patients with Hepatitis
|
Plasma Real Time-Quantitative Polymerase Chain Reaction of Epstein-Barr Virus in Immunocompetent Patients with Hepatitis
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Ji Hye Hong(Yonsei University); Yon Jung Bae(Yonsei University); 손준형(연세대학교); Byung Il Ye(Yonsei University); Jin-Kyong Chun(Yonsei University); Hwang Min Kim(Yonsei University)"
] |
Purpose: Epstein-Barr virus (EBV) hepatitis is a usually asymptomatic and self-limiting disease in immunocompetent patients. However, the range of severity is wide, and the serological diagnosis is typically difficult until the convalescent phase. Thus, we examined the value of plasma EBV DNA real-time quantitative polymerase chain reaction (RT-qPCR) in EBV hepatitis for the timely diagnosis and the relationship between EBV viral load and clinical severity. Methods: Sixty samples were confirmed as having EBV infection by RT-qPCR with the EBV BALF5 gene sequence. We examined the clinical characteristics of EBV hepatitis by reviewing medical records.
Results: The median total duration of fever was 8 days (range: 0-13 days). The mean peak value of aspartate aminotransferase (AST) was 241±214 U/L, and the mean peak value of alanine aminotransferase (ALT) was 298±312 U/L. There was no correlation between the serum levels of liver enzyme and plasma EBV DNA titer (p=0.1) or between median total duration of fever and EBV DNA titer (p=0.056). The median age of the EBV VCA IgM-negative group was lower compared with the EBV VCA IgM-positive group in EBV hepatitis (2 years vs. 6 years, p=0.0009).
Conclusion: The severity of EBV hepatitis does not correlate with circulating EBV DNA load according to our data. Furthermore, we suggest that plasma EBV PCR may be valuable in young infants in whom the results of serology test for EBV infection commonly are negative.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001648674
|
oai_dc
|
The Role of Capsule Endoscopy in the Diagnosis of Crohn’s Disease
|
The Role of Capsule Endoscopy in the Diagnosis of Crohn’s Disease
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Kang Won Rhee(Pusan National University)"
] |
The examination of small bowel in Crohn’s disease (CD) is very important. Capsule endoscopy (CE) has been recognized as a good tool for evaluation of small bowel. The capsule placement is achieved endoscopically for Children not to swallow capsule. CE is superior to any other modalities for examination of small-bowel. The large portion of pediatric patients with known CD were found with CE to have more extensive and newly diagnostic small-bowel disease. All of them had therapeutic changes. The most side effect of CE is capsule retention. The capsule retention rate in pediatric CD is about 7.3%. The patency capsule helps to predict the possibility of capsule retention. For the improving of the diagnostic accuracy, the experience of more than 20 readings of CE is needed.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001648697
|
oai_dc
|
Role of Tumor Necrosis Factor-a Promoter Polymorphism and Insulin Resistance in the Development of Non-alcoholic Fatty Liver Disease in Obese Children
|
Role of Tumor Necrosis Factor-a Promoter Polymorphism and Insulin Resistance in the Development of Non-alcoholic Fatty Liver Disease in Obese Children
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"양혜란(서울대학교); Jeong Kee Seo(Seoul National University); 고재성(서울대학교)"
] |
Purpose: Tumor necrosis factor-α (TNF-α) polymorphism has been suggested to play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) in obese adults, and known to be a mediator of insulin resistance. In this study, we evaluated the role of TNF-α promoter polymorphisms and insulin resistance in the development of NAFLD in obese children. Methods: A total of 111 obese children (M：F=74：37; mean age, 11.1±2.0 yrs) were included. The children were divided into 3 groups: controls (group I, n=61), children with simple steatosis (group II, n=17), and children with non-alcoholic steatohepatitis (group III, n=33). Serum TNF-α levels, homeostasis model assessment of insulin resistance (HOMA-IR), and TNF-α -308 and -238 polymorphisms were evaluated. Results: There were no differences in TNF-α polymorphism at the -308 or the -238 loci between group I and group II + III (p=0.134 and p=0.133). The medians of HOMA-IR were significantly different between group I and group II + III (p=0.001), with significant difference between group II and group III (p=0.007). No difference was observed in the HOMA-IR among the genotypes at the -308 locus (p=0.061) or the -238 locus (p=0.207) in obese children. Conclusion: TNF-α promoter polymorphisms at the -308 and -238 loci were not significantly associated with the development of NAFLD in children; nevertheless, insulin resistance remains a likely essential factor in the pathogenesis of NAFLD in obese children, especially in the progression to NASH.
|
소아과학
| null |
kci_detailed_000002.xml
|
|||
ART001648673
|
oai_dc
|
Noroviruses: Recent Updates
|
Noroviruses: Recent Updates
|
{
"journal_name": "대한소아소화기영양학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
}
|
[
"Ju-Young Chung(Inje University)"
] |
Noroviruses (NoVs) are one major etiologic agent in acute gastroenteritis (AGE) in all ages and are the primary cause of food-borne gastroenteritis worldwide. GII-4 NoVs has predominated since 1990s, and novel recombinant strains have been reported worldwide. Researchers face difficulties in making vaccines and therapeutic agents against NoVs due to the lack of cell culture and animal-model systems and the rapid emergence of novel variant strains. Recently, a randomized clinical trial for intranasal NoVs vaccine has been reported, which casts a light in the way of vaccine production. This review discusses the recent findings on the structure, immunity, and vaccination of NoVs.
|
소아과학
| null |
kci_detailed_000002.xml
|
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