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CONFLICT OF INTEREST STATEMENT | The authors declare no conflicts of interest. | PMC10770821 | ||
ETHICS STATEMENT | DISEASES | The experiment was performed after an informed consent form was signed by each participant and confirming that none of the students had cardiovascular or other lethal diseases. The study was conducted in accordance with the Declaration of Helsinki and approved by the Bioethics Commission of Hainan Medical University (H... | PMC10770821 | |
ACKNOWLEDGMENTS | TopEdit | The authors extend their thanks to the 2022 Hainan Province Philosophy and Social Science Planning project and the 2021 Project supported by the education financial support from the Department of Hainan Province. The authors would also like to thank TopEdit ( | PMC10770821 | |
DATA AVAILABILITY STATEMENT | The raw data supporting the conclusions of this article will be made available by the authors upon reasonable request. | PMC10770821 | ||
REFERENCES | PMC10770821 | |||
Background: | ESSENTIAL TREMOR | Transcutaneous afferent patterned stimulation (TAPS) is a wrist-worn, non-invasive therapy delivering calibrated stimulation to the median and radial nerves. Previous randomized controlled studies have demonstrated the efficacy and safety of TAPS therapy in some patients with essential tremor (ET), but evidence support... | PMC10588491 | |
Methods: | tremor | SECONDARY | This randomized pragmatic trial recruited patients from a large health plan’s Commercially Insured and Medicare Advantage population. All 310 patients received a TAPS device and were randomized 1:1 to either one month adding TAPS therapy to usual care (TX arm) or usual care with tremor assessment only (SOC arm). The pr... | PMC10588491 |
Results: | tremor | SECONDARY | 276 patients completed the one-month study (N = 133 TX, N = 143 SOC). The study met the primary and secondary endpoints, with significantly reduced tremor power in TX compared with SOC (0.017 (0.003) versus 0.08 (0.014) (m/s | PMC10588491 |
Discussion: | tremor | This trial demonstrates that adding TAPS treatment to SOC significantly improves tremor power and BF-ADLs in patients with ET compared to SOC alone over one month of home use. | PMC10588491 | |
Highlights | tremor | This study found that adding TAPS treatment to SOC significantly improves tremor power and BF-ADL scores in patients with ET compared to SOC alone over one month of home use. This real-world evidence study suggests that non-invasive TAPS therapy is a safe and valuable treatment option for patients with ET. | PMC10588491 | |
Introduction | Parkinson’s disease, tremors | ESSENTIAL TREMOR | Patients living with postural and kinetic hand tremors struggle with key activities of daily living such as eating, drinking, and writing [Pharmacological treatments are the primary therapy option for management of ET; however, they are often either ineffective, contraindicated, or associated with side effects that lea... | PMC10588491 |
Methods | PMC10588491 | |||
Study Design | This randomized pragmatic trial recruited patients from the database of a large health insurer (Aetna/CVS Health). All enrolled patients were initially prescribed a TAPS device and then randomized to treatment (TX) or standard of care (SOC) for one month of home use. Patients in the TX arm added TAPS to their physician... | PMC10588491 | ||
Patient Randomization | Participants receiving a physician prescription were randomized 1:1 to the TX or SOC arm following a randomization list generated by a study statistician. Randomization was stratified by insurance type (commercial health insurance or Medicare Advantage plan) to ensure a balanced distribution of ages between the TX and ... | PMC10588491 | ||
Patient Enrollment and Training | tremor, comorbidity | Patients in both arms scheduled an appointment with patient support personnel at Cala Health to complete enrollment and training on proper use of the device (Cala Trio™, Cala Health, San Mateo, CA, USA). All patients received a standard TAPS delivery containing three components sent directly to their home: (1) a wrist-... | PMC10588491 | |
Data Collection | ADVERSE EVENT | Demographic and clinical data were collected either directly from patients or abstracted from the patients’ medical and pharmacy claims in the health plan’s administrative claims database and entered into the electronic Case Report Form (eCRF) by trained study personnel. Comorbid conditions in the medical claims were i... | PMC10588491 | |
Statistical Analyses | SECONDARY | Analyses were performed according to a prespecified statistical analysis plan. Descriptive analyses present distributions as frequency (%) for categorical variables and means with standard deviations (SDs) or medians with interquartile ranges (IQR), as appropriate, for continuous variables. Differences between the stud... | PMC10588491 | |
Primary Endpoint | tremor, Tremor | The study’s pre-specified primary endpoint was the difference in median tremor power for patients in the TX versus SOC arm in the mITT, with statistical significance evaluated using a Wilcoxon rank-sum test. Tremor power for each patient in the TX arm was the median tremor power measured during postural holds performed... | PMC10588491 | |
Secondary Endpoint | SECONDARY | The study’s pre-specified secondary endpoint was the difference in BF-ADL upper limb score improvement from baseline to the end of the first month for patients in the TX arm versus the SOC arm in the mITT, with statistical significance evaluated using a two-sample t-test. BF-ADL upper limb scores for both arms were sum... | PMC10588491 | |
Exploratory Endpoints | tremor, TPIR | Pre-specified exploratory analyses of BF-ADL scores in the mITT included assessment of improvement in BF-ADL score from baseline to one month within each arm, and improvement in individual BF-ADL tasks from baseline to one month within each arm. A two-sample t-test with Holm-Bonferroni corrections for multiple hypothes... | PMC10588491 | |
Severe ET Subgroup Analyses | SECONDARY | A subgroup of more severe patients was defined as patients who scored a 3 or 4 on at least one of four BF-ADL tasks associated with eating, drinking, or writing at baseline. These included: (1) write a letter, (2) use a spoon to drink soup, (3) hold a cup of tea, and (4) pour milk from a bottle. The primary and seconda... | PMC10588491 | |
TAPS Device Usage Analysis | Usage in the TX group, as pre-specified, was assessed as the number of therapy sessions per week, total days per week with at least one therapy session, and the average number of therapy sessions per day on days therapy was used. Usage assessments were further stratified by age and gender. | PMC10588491 | ||
Sample Size Calculation | The study sample size was calculated to sufficiently power the study’s primary endpoint. A 25% patient attrition was assumed based on the one-month dropout rate in a previous study [ | PMC10588491 | ||
Results | PMC10588491 | |||
Secondary Endpoint | ± | SECONDARY | The secondary endpoint was also met in both the mITT and PP populations. 134 of the 276 patients completed the BF-ADL ratings at baseline and one month. The changes in BF-ADL score from baseline to one month in the TX arm (1.6 ± 0.43, N = 51) were significantly greater than the changes observed in the SOC arm (0.22 ± 0... | PMC10588491 |
Severe ET Subgroup Analysis | tremor | SECONDARY | TAPS significantly improved tremor power in the severe subgroup, in which tremor power was 0.02 (0.003) (m/sSevere subgroup analyses of primary and secondary endpoints between TX and SOC arm in the mITT population** Severe patients were classified as having at least one of 4 tasks which impacts eating, drinking, or wri... | PMC10588491 |
Adverse Events | dizziness, skin irritation, sores | ADVERSE EVENTS, EVENTS | Four patients (3%) reported temporary wrist skin irritation, sores, discomfort, or dizziness including unpleasant stimulation during the one-month study period. All these events were resolved without professional medical attention. No TAPS therapy-related serious adverse events reported. | PMC10588491 |
Discussion | tremor, Tremor, tremors | ADVERSE EVENTS | This was the first randomized pragmatic clinical trial comparing TAPS to SOC in patients with ET, as well as the first randomized TAPS study that included use of TAPS at-home. The study demonstrated that adding TAPS therapy to SOC significantly improved tremor power and BF-ADLs compared to SOC alone during one month of... | PMC10588491 |
Limitations | non-conscious | There are several limitations associated with this randomized pragmatic clinical trial run during the COVID-19 pandemic that could affect interpretation of these results. First, the open-label design could be confounded with bias, including non-conscious communication of positive biases to patients and biases by study ... | PMC10588491 | |
Conclusion | SOC reduced tremor | This is the first randomized large-scale pragmatic clinical trial to evaluate unsupervised TAPS use in a real-world home-base setting. The study demonstrated that adding TAPS therapy to existing SOC reduced tremor power and increased improvements in BF-ADL upper limb scores during one month of home use compared to SOC ... | PMC10588491 | |
Meeting Presentation | Parkinson’s Disease | MOVEMENT DISORDERS | These data have previously been presented as posters at the International Congress of Parkinson’s Disease and Movement Disorders, Madrid, Spain, September 15–18, 2022, and the AMCP 2023, San Antonio, TX, March 21–24, 2023. | PMC10588491 |
Additional File | The additional file for this article can be found as follows:Table S1–S2 and Figure S1–S3. | PMC10588491 | ||
Funding Information | This study was sponsored by Cala Health, Inc. | PMC10588491 | ||
Competing Interests | D Dai, J Fernandes, and H Coetzer are employees of CVS Health Clinical Trial Services LLC, which received funding from Cala Health, Inc. to complete this research. H Kim is an employee of Cala Health Inc. at the time the study was conducted. The authors report no other potential conflicts of interest. | PMC10588491 | ||
1. Introduction | pre-eclampsia, anxiety, multisystem disorder, depressive symptoms, depression | PRE-ECLAMPSIA, PRE-ECLAMPSIA | Objective: This study aims to extend the understanding of the psychological impact of the first-trimester pre-eclampsia (PE) screening on women identified as high risk for preterm PE. We examined the differences between low- vs. high-risk women throughout pregnancy in: symptoms of distress (anxiety, depression, physica... | PMC10094560 |
2. Materials and Methods | PMC10094560 | |||
2.1. Study Design and Sample | Pre-eclampsia | PRE-ECLAMPSIA, PREGNANCY LOSS | This study was nested within the ASPRE (Aspirin for Evidence-Based Pre-eclampsia Prevention) trial; the study inclusion criteria and procedure were published previously [The current study was conducted in the UK in two ASPRE-trial-participating hospitals. The only departure from the described ASPRE trial study inclusio... | PMC10094560 |
2.2. Procedure | Women attending their routine 11–13 ultrasound appointment were offered the opportunity to be screened for preterm-PE risk status as part of the ASPRE trial. They were informed about the aims of the psychological evaluation that was carried out independently from the medical research. Participants who consented to taki... | PMC10094560 | ||
2.4. Data Analysis | high-risk-for-preterm-PE, depression | REGRESSION, RECRUITMENT | To examine the impact of first-trimester PE screening and prevention throughout pregnancy, we first examined the background differences across relevant demographic and obstetrics factors between the low- and high-risk-for-PE women (at time 2) using Student’s Given the identified differences between the low- and high-ri... | PMC10094560 |
4. Discussion | generalised, lower depression, anxiety, depressive, depressive symptoms, depression | RECRUITMENT, BLIND | Although it has been well documented that first-trimester PE screening is of clinical value [The study findings revealed that, among the various psychological distress outcomes considered, women identified to be at high risk for PE during the first-trimester screening exhibited more depressive symptoms at 22 weeks of p... | PMC10094560 |
5. Conclusions | depression, anxiety, depressive symptoms | ADVERSE EFFECTS | Our study offers novel insights concerning the psychological impact of the first-trimester screening for PE. The findings revealed that, overall, pregnant women had positive attitudes towards PE screening, and that the pregnancy experiences of those identified to be at high risk following the first-trimester PE screeni... | PMC10094560 |
Supplementary Materials | The following supporting information can be downloaded at: Click here for additional data file. | PMC10094560 | ||
Author Contributions | A.V.N. and K.H.N. designed the study. C.M., C.S. and A.V.N. analysed the data. A.V.N. wrote the paper with the help of other authors (C.S., C.M., N.O., L.C.P., K.H.N.). A.V.N. will act as guarantor for the paper. All authors have read and agreed to the published version of the manuscript. | PMC10094560 | ||
Institutional Review Board Statement | NRES Committee London—Surrey Borders ref 14/LO/1238 (date of favourable ethics opinion: 13 August 2014). | PMC10094560 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10094560 | ||
Data Availability Statement | Data are available on request to the corresponding author. | PMC10094560 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC10094560 | ||
References | Depression | PREECLAMPSIA | Simple slope analysis for Risk group x Depression interaction at time 3 on Life-Style Behaviours. Note: PE = preeclampsia; PE risk group 1 = low risk of preeclampsia/PE risk group 2 = high risk of preeclampsia.Baseline sociodemographic characteristics of the included population (N = 282) by group.Note. data are given a... | PMC10094560 |
Abstract | PMC10476902 | |||
Background | lung cancer | LUNG CANCER | A recent trend in postoperative analgesia for lung cancer surgery relies on regional nerve blocks with decreased opioid administration. Our study aims to critically assess the continuous ultrasound-guided | PMC10476902 |
Patients and methods | lung cancer, cough, ESPB, pain | LUNG CANCER, SECONDARY | A prospective randomized-control study was performed to compare outcomes of patients, scheduled for video-assisted thoracoscopic (VATS) lung cancer resection, allocated to the ESPB or ICNB group. Primary outcomes were total opioid consumption and subjective pain scores at rest and cough each hour in 48 h after surgery.... | PMC10476902 |
Results | ESPB | 60 patients met the inclusion criteria, half ESPB. Total opioid consumption in the first 48 h was 21. 64 ± 14.22 mg in the ESPB group and 38.34 ± 29.91 mg in the ICNB group (p = 0.035). The patients in the ESPB group had lower numerical rating scores at rest than in the ICNB group (1.19 ± 0.73 | PMC10476902 | |
Conclusions | ESPB, pain | POSTOPERATIVE COMPLICATIONS | In the first 48 h after surgery, patients with continuous ESPB required fewer opioids and reported less pain than patients with ICNB. There were no differences regarding respiratory muscle strength, postoperative complications, and time to hospital discharge. In addition, continuous ESPB demanded more surveillance than... | PMC10476902 |
Keywords | PMC10476902 | |||
Introduction | lung cancer, empyema, ESPB | LUNG CANCER, EMPYEMA, PLEURAL INFECTION | Post-operative analgesia is crucial for early rehabilitation in thoracic surgery, as patients are required to actively participate in respiratory physiotherapy.In an attempt to find safe and less invasive methods of postoperative analgesia, new techniques of nerve blocks have emerged. Among other peripheral blocks, int... | PMC10476902 |
Patients and methods | The study was approved by the National Ethics Committee under the number 0120-372/2019/7 and the study was registered to the Clinical Trial Registry under number NCT04665531. | PMC10476902 | ||
Patients | inflammation, allergy, ESPB | INFLAMMATION, ALLERGY, LOCAL ANESTHETIC SYSTEMIC TOXICITY, CHRONIC PAIN SYNDROME | Sixty participants were enrolled between the 19Other inclusion criteria were ASA status I–III and informed written consent for participation in the study. Exclusion criteria were chronic pain syndrome, chronic opioid use, weight less than 50 kg due to risk of local anesthetic systemic toxicity (LAST), body mass index (... | PMC10476902 |
Nerve block technique | tumor, ESPB | STERILE, TUMOR, PERIOSTEUM, INFILTRATED | Patients in the ICNB group received a single-shot intrathoracic ICNB after tumor extraction, approximately 30 minutes before the end of the surgery. They received 20 ml of 0.5% levobupivacaine with injections at 6 intercostal spaces, adjacent to the surgical wound. The perineural intercostal space was located under dir... | PMC10476902 |
Peri-operative protocol | ESPB, neuromuscular block, pain, cough, infection, NRS | BLOOD, INFECTION | All the patients underwent the same anesthesia protocol. Induction to general anesthesia was conducted with 1.5–2 mg/kg propofol 1% and 0.75–1 mcg/kg remifentanil in a slow bolus followed by 0.6 mg/kg rocuronium. Total intravenous anesthesia was maintained with an infusion of 5 mg/kg/h propofol 1% and 0.02–0.03 mcg/kg/... | PMC10476902 |
Statistical analysis | The statistical analyses were performed using IBM SPSS version 25, Orange data mining and visualization suite. | PMC10476902 | ||
Results | bleeding, ESPB, infections, sinus tachycardia, cough, arrhythmias, NRS | BLEEDING, SINUS TACHYCARDIA, INFECTIONS, ARRHYTHMIAS, PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA, COMPLICATIONS | Patient allocation and follow-up are shown in the Consolidated Standards of Reporting Trials (CONSORT) flow diagram (CONSORT flow diagram.ESPB There were no statistically significant demographic differences between the study groups considering gender, age, body mass index, type of surgery, ASA and forced expiratory vol... | PMC10476902 |
Discussion | lung cancer, cardiac arrhythmias, ESPB, cardiotoxicity | LUNG CANCER, CARDIAC ARRHYTHMIAS, RECRUITMENT, COMPLICATIONS | This study of postoperative analgesia for VATS lung cancer resection, comparing continuous ultrasound-guided ESPB versus ICNB, is the first of its kind in Slovenia. Due to the Covid-19 pandemic crisis, causing limited resources and additional healthcare concerns, the time of patient recruitment was prolonged, and only ... | PMC10476902 |
Conclusions | cough, ESPB, pain | LUNG TUMOR | The study in our institution showed that the continuous ESPB decreases total opioid consumption and subjective pain perception at rest in the first 48 hours after VATS lung tumor resection compared to the intrathoracic ICNB. On the other hand, ESPB demands more nursing care. Regarding time to chest tube removal, hospit... | PMC10476902 |
Acknowledgments | Authors would like to thank the doctors and nursing staff at the Surgery Bitenc Clinic who contributed to the study's final realization.Disclosure: No potential conflicts of interest were disclosed. | PMC10476902 | ||
References | PMC10476902 | |||
1. Introduction | Research suggests that mental activation of human social support may reduce stress reactivity. However, the extent to which social support from pets elicits a similar effect has been less explored. This study aims to determine whether the mental activation of one’s pet dog reduces stress reactivity to a subsequent expe... | PMC10648142 | ||
1.1. Background and Significance | Social support has long been recognized as vital to human health and wellbeing [In addition to human social support, research has recently begun to examine the effect of animal-derived social support on stress reactivity. Historically, companion animals (i.e., pets) have been recognized as providers of instrumental soc... | PMC10648142 | ||
1.2. Mental Activation of Social Support | Because a supportive figure may not be physically present during all stressful situations that occur in life, of interest is the possibility that simply thinking about a social tie may be beneficial. Specifically, researchers have investigated if mentally activating an internal representation of social support (i.e., s... | PMC10648142 | ||
1.3. Aims of the Current Research | The first aim of the current study was to determine whether mental activation of one’s pet dog reduces stress reactivity during a mild stressor. We hypothesized that individuals who completed a structured writing activity about their pet dog prior to completing a stressor would report higher positive affect and less ca... | PMC10648142 | ||
2. Materials and Methods | PMC10648142 | |||
2.1. Participants | Participants were N = 132 dog-owning undergraduate and graduate students over the age of 18 attending a large public university in the United States. We restricted participants to dog owners to provide consistency and because relationships with pet dogs tend to be stronger than relationships with other types of pets [ | PMC10648142 | ||
2.2. Study Design | All protocols were approved by the Purdue University Institutional Review Board (Protocol #13-4660H). Participants were randomized to one of two mental activation conditions (asked to think/write about a memory of their pet dog or asked to think/write about any positive memory as a comparison) and to one of two stresso... | PMC10648142 | ||
2.3. Procedures | All procedures occurred during a single visit to an observational laboratory over 35 min (After the mental activation phase, the stressor phase began. Participants were randomized to either a social-evaluative stressor or a cognitive stressor. Both stressors lasted approximately 15-min, and physiological data were coll... | PMC10648142 | ||
2.4. Measures | POSITIVE | Demographic information collected from participants included age, gender identity, and race/ethnicity. In addition, participants reported on health behaviors that are associated with physiological functioning (consumption of caffeine, alcohol, and nicotine over the 24 h prior to the visit, medication taken and physical... | PMC10648142 | |
2.5. Analytic Plan | All analyses were conducted in SPSS version 28.0 (IBM Statistics, Armonk, NY, USA). One-way ANOVA and chi-squared tests were used to ensure that randomization resulted in no significant between-group differences in demographic continuous and categorical variables. SBP, DBP, and HR data were screened for outliers, and o... | PMC10648142 | ||
3. Results | Participants did not significantly differ in age ( | PMC10648142 | ||
4. Discussion | PHYSIOLOGICAL STRESS | The objective of this study was to determine to what extent mental activation of one’s pet dog reduces stress reactivity to a social-evaluative or cognitive stressor. Results suggested that participants who wrote and thought about their pet dog prior to an experimental stressor reported less of a decrease in positive a... | PMC10648142 | |
Limitations and Future Directions | Results of this study should be interpreted with the following limitations in mind. First, the sample was not representative; using non-probability convenience sampling, we obtained a sample that was 92% White, 80% female, and all dog-owning undergraduate or graduate students at a university. It is likely that there wa... | PMC10648142 | ||
5. Conclusions | This study found that pet dog owners that mentally activated a memory with their pet dog reported less of a decrease in positive affect from before to after an experimental stressor compared to participants that mentally activated a general positive memory not featuring their dog, regardless of the type of stressor rec... | PMC10648142 | ||
Author Contributions | Conceptualization, D.J.G. and R.G.L.-T.; methodology, D.J.G. and R.G.L.-T.; formal analysis, K.E.R.; investigation, R.G.L.-T.; writing—original draft, K.E.R.; writing—review and editing, K.E.R., D.J.G. and R.G.L.-T.; supervision, D.J.G. and R.G.L.-T. All authors have read and agreed to the published version of the manu... | PMC10648142 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Purdue University (Protocol #13-4660H, approved on 13 March 2014). | PMC10648142 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10648142 | ||
Data Availability Statement | Data are available on request. | PMC10648142 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC10648142 | ||
References | Experimental procedure.Graphs displaying changes in positive affect (PA), negative affect (NA), and negative self-evaluation (NSE) from baseline to post-stressor across groups.Graphs displaying diastolic blood pressure (DBP), systolic blood pressure (SBP), and heart rate (HR) during the baseline, mental activation, and... | PMC10648142 | ||
Abstract | vascular stiffness, cardiometabolic disease | OVERWEIGHT AND OBESITY | Overweight and obesity (Ow/Ob) is a risk factor for cardiometabolic disease. Caloric restriction (CR) have been investigated but little is known about the acute effects of CR and often such diets are not standardized. Thus, we aimed to assess the impact of a new standardized 3‐day CR diet (590 kcal/d intake) on cardiom... | PMC10659943 |
INTRODUCTION | metabolic inflexibility, overweight, metabolic dysfunction | OBESE, DISEASE | According to the Centers for Disease Control (CDC), more than 42% of adults are classified as obese, and approximately 74% of US adults are classified as overweight (body mass index of 25.0 to <30 kg/mObesity is associated with physiological disruption, specifically metabolic dysfunction such as impaired ability to use... | PMC10659943 |
METHODS | PMC10659943 | |||
Subjects and general procedures | Participants were recruited via email and publicly posted flyers from the Saratoga Springs, NY community. To be included participants must have been Ow or Ob (defined as BMI > 27.5 kg/mExperimental overview. ↓ perceptual survey was completed. | PMC10659943 | ||
Procedures | This study was an open‐label, single‐arm study design, see overview of the study procedures in Figure Participants were then positioned supine, and allowed to rest for 10 min, during this time we instrumented them with an oscillometric blood pressure cuff. Peripheral blood pressure, estimated central blood pressure and... | PMC10659943 | ||
Biomarker analysis | INSULIN RESISTANCE, ALDRICH | To estimate in vivo biological effects of the 3‐day CR, plasma samples were analyzed using commercially available assay kits for ketone bodies (b‐hydroxybutyric acid, BOH; and acetoacetic acid, AcAc; Sigma Aldrich, Burlington, MA), factors that regulate metabolism (insulin, thyroid stimulating hormone, cortisol; RayBio... | PMC10659943 | |
Data and statistical analysis | In a paired samples | PMC10659943 | ||
RESULTS | PMC10659943 | |||
Participants | The fifteen individuals who completed the study were nearly middle aged, with a relatively even split of men and women (Table Participant characteristics ( | PMC10659943 | ||
Impact of | The 3‐day CR diet significantly lowered body weight by 3% (The effect of the 3‐day CR diet on body weight (Panel a), body mass index (BMI, Panel b), body composition (Panels c–f), and waist‐hip circumferences (Panel g–i) in overweight/obese men and women ( | PMC10659943 | ||
Impact of | The 3‐day CR diet had no significant effect on peripheral systolic (pSBP; The effect of the 3‐day CR diet on peripheral (p, Panel a–c) and central (c, Panel d–f) systolic (SBP), diastolic (DBP), and mean arterial (MAP) blood pressures, heart rate (Panel g), augmentation pressure (Panel h), and augmentation index (Panel... | PMC10659943 | ||
Impact of | The 3‐day CR diet had no significant effect on blood glucose (The effect of the 3‐day CR diet on blood lipids (Panels a–e) and glucose (Panel f) in overweight/obese men and women ( | PMC10659943 | ||
Impact of | The 3‐day CR diet had no significant effect on VOThe effect of the 3‐day CR Diet on resting metabolism (volume of oxygen consumed, VO | PMC10659943 | ||
Impact of | BLOOD | The 3‐day CR diet had no significant effect on 3‐hydroxybutryic acid, cortisol, insulin, neuropeptide Y, ghrelin, protein YY, or on sirtuin 1 (all: Blood assay biomarker analysis.
| PMC10659943 | |
Impact of | fullness, hunger, desire | The 3‐day CR diet had no significant effect on self‐reported perceptions or feelings of hunger, desire to eat, or fullness (all: | PMC10659943 |
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