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PATIENTS AND METHODS | In this study, single‐blind participants are blinded to the parallel group that was initiated within a single institution. The study was approved by the Saga University Hospital Research Ethics Committee (Protocol number 2019‐07‐01), and informed consent was obtained from all subjects and/or legally acceptable represen... | PMC10728525 | ||
Participants and study design | undernutrition, mandibular fracture | UNDERNUTRITION | The study subjects were patients in the Department of Dental and Oral Surgery of Saga University Hospital (Saga, Japan) who required maxillomandibular fixation either after orthognathic surgery or for the treatment of mandibular fracture between October 2019 and December 2022. The subjects were allocated by the envelop... | PMC10728525 |
Evaluation parameters | carious bacteria, caries, tooth surface/total tooth, caries, periodontal disease, tooth | ADHESION, PERIODONTAL DISEASE, CARIES, PLAQUE |
Assessment of plaque adhesion status using the plaque control record (PCR).Measurements with a saliva analyzer (Sill‐Ha, Arkray Marketing Inc.).Plaque‐disclosing dye (Shofu Inc.) was used to dye all the remaining tooth surfaces, and the state of plaque adhesion on the surface in the cervical region was scored. The met... | PMC10728525 |
Statistical analysis | SECONDARY | JMP version 14 was used for statistical analysis. The primary and secondary endpoints were compared between the HABITPRO and placebo groups. Student's | PMC10728525 | |
RESULTS | PMC10728525 | |||
Study flow and baseline characteristics | The flow of patients throughout this study is depicted in Figure Flow diagram of patients throughout the study.Patient distribution.
| PMC10728525 | ||
The effectiveness of HABITPRO mouthwash on plaque control record | tooth | PLAQUE, DENTAL PLAQUE, PLAQUE | To assess the intraoral environment, the amount of dental plaque was evaluated using PCR as the primary endpoint. The PCR index varied widely at baseline. After fixation release, in the placebo group, the index increased by +24.61 compared with baseline, with an increase in the amount of plaque adhering to the teeth, w... | PMC10728525 |
The effectiveness of HABITPRO mouthwash on salivary properties | caries, carious bacteria | PERIODONTAL DISEASE, CARIES | We investigated six parameters in saliva (carious bacteria, pH, acid buffering capacity, leukocyte count, protein levels, and ammonia levels) to verify whether HABITPRO mouthwash affects caries, periodontal disease, and oral cleanliness (Table Salivary properties.Abbreviation: IMF, intermaxillary fixation.
The bufferin... | PMC10728525 |
DISCUSSION | bad breath, caries, pain, mucositis, tooth | ADVERSE EVENTS, CARIES, ADHESION, PERIODONTAL DISEASE, MUCOSITIS, ASPIRATION PNEUMONIA | Recent years have seen rising interest in oral health management. Although the rate of mouthwash use is not necessarily higher in Japan than in other countries, it has tended to increase in recent years. Initially, most people thought that mouthwash was used to eliminate bad breath, and it was often lumped together wit... | PMC10728525 |
CONCLUSIONS | The present results suggest that the continued perioperative use of a mouthwash containing active ingredients may suppress the deterioration of the oral environment to some extent, even in the specific environment resulting from maxillomandibular fixation. This mouthwash may therefore provide a tool for perioperative o... | PMC10728525 | ||
CLINICAL RELEVANCE | PMC10728525 | |||
Scientific rationale for the study | mandibular fracture | DENTAL CARIES, PERIODONTAL DISEASE, WOUND INFECTIONS, ASPIRATION PNEUMONIA, DISEASES | Management of the oral environment in patients with diseases of oral and maxillofacial region is very important to reduce not only the aggravation of dental caries and periodontal disease, but also local wound infections and aspiration pneumonia. Patients who required maxillomandibular fixation for the treatment of man... | PMC10728525 |
Principal findings | CPC/GK2/TXA‐based mouthwash reduced the ammonia level related to oral cleanliness in saliva and the PCR index after fixation release. | PMC10728525 | ||
Practical implications | The continued use of CPC/GK2/TXA‐based mouthwash may suppress the deterioration of the oral environment, even in the specific environment resulting from maxillomandibular fixation. This mouthwash may be useful in perioperative oral hygiene management. | PMC10728525 | ||
AUTHOR CONTRIBUTIONS | Yoshio Yamashita designed the study, Reona Aijima performed the experiments, all authors interpreted data, and Yoshio Yamashita wrote the manuscript. All authors reviewed the manuscript. | PMC10728525 | ||
CONFLICT OF INTEREST STATEMENT | The authors declare no conflict of interest. | PMC10728525 | ||
ACKNOWLEDGMENTS | The authors are grateful to participating staff members from the Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saga University. | PMC10728525 | ||
DATA AVAILABILITY STATEMENT | The data that support the findings of this study are available from the corresponding author upon reasonable request. | PMC10728525 | ||
REFERENCES | PMC10728525 | |||
Background: | hypertensive cerebral hemorrhage, hemiplegia, tibialis anterior muscle resistance | This study aimed to investigate the effect of tibialis anterior muscle resistance training on ankle and foot dorsum extension function in patients with hemiplegia caused by hypertensive cerebral hemorrhage. | PMC10403024 | |
Methods: | cerebral hemorrhage, hemiplegia, hypertensive | CEREBRAL HEMORRHAGE, CONTRACTION | Fifty cases of hypertensive cerebral hemorrhage in patients with hemiplegia were selected according to the random number table method. The patients were divided into the treatment group and control group. Each group included 25 cases, and the treatment group was given routine rehabilitation treatment and passive and ac... | PMC10403024 |
Results: | There was no significant difference in surface electromyography between the 2 groups before treatment ( | PMC10403024 | ||
Conclusions: | hypertensive cerebral hemorrhage, hemiplegia, Tibialis anterior muscle resistance | Tibialis anterior muscle resistance training can effectively improve the strength of the tibialis anterior muscle in patients with hemiplegia caused by hypertensive cerebral hemorrhage, reduce tension in the triceps calf muscle, and improve ankle joint function and foot dorsum extension. | PMC10403024 | |
1. Introduction | cerebral hemorrhage, Stroke, stroke, hemiplegia, strokes | CEREBRAL HEMORRHAGE, STROKE, STROKE, ISCHEMIC STROKE, STROKES | Stroke is a common and frequently occurring condition in clinical practice. The incidence of cerebral hemorrhage in all stroke subtypes is second only to that of ischemic stroke. According to a domestic epidemiological survey, the proportion of cerebral hemorrhage in China is higher than that in Western countries, acco... | PMC10403024 |
2. Clinical data | PMC10403024 | |||
2.1. Case selection criteria | tibial anterior muscle, consciousness disorders, lower limb dysfunction, liver and kidney dysfunction, intracerebral hemorrhage, cerebral hernia, amputation, cord injury, vertigo, balance dysfunction, infection, hypertensive, coagulopathy, vestibular dysfunction, aphasia, venous thrombosis, trauma | MYOCARDIAL INFARCTION, INTRACEREBRAL HEMORRHAGE, DISEASE COURSE, HEMATOLOGICAL DISEASES, JOINT DISEASES, CEREBELLAR LESIONS, INFECTION, HYPERTENSIVE INTRACEREBRAL HEMORRHAGE, VENOUS THROMBOSIS, COAGULOPATHY, COMPLICATIONS, NEOPLASTIC DISEASE | In accordance with the diagnosis of hypertensive intracerebral hemorrhage, the diagnostic criteria refer to the diagnostic criteria of the Chinese Multidisciplinary Diagnosis and Treatment Guidelines for hypertensive intracerebral hemorrhageInclusion criteria were as follows: patients aged 30 to 70 years, patients who ... | PMC10403024 |
2.2. General data | blood loss, craniocerebral injury | BLOOD LOSS, DISEASE | A total of 50 patients with craniocerebral injury were admitted to the Department of Neurosurgery, and the sample size was determined by referring to previous similar randomized controlled experiments. Patients from the Second People’s Hospital of Yibin from January 2020 to January 2022 were selected and divided into t... | PMC10403024 |
3. Method | PMC10403024 | |||
3.1. Treatment methods | cramps, knee ankle foot orthoses or ankle foot | Methods rehabilitation training was carried out by the same group of rehabilitation therapists.The control group was given conventional rehabilitation techniques such as stretching, muscle strength, balance and wearing orthoses. According to the actual movement function in patients with grade wearing knee ankle foot or... | PMC10403024 | |
3.2. Observation indices | Before treatment and 2 months after treatment, the electromyography (EMG) of the affected side of the tibialis anterior and peroneus longus muscles was recorded using the SA7550 surface EMG analysis system produced by Nanjing Weis Medical Co., Ltd. Before and after treatment, the root mean square (RMS) value of the tri... | PMC10403024 | ||
3.3. Statistical analysis | SPSS17.0 software (International Business Machine, Armonk, NY) was used to analyze SPSS data. The data did not conform to a normal distribution; therefore, the nonparametric rank sum test (Mann–Whitney IQR comparison of treatment data between the 2 groups (IQR).IQR = interquartile range. | PMC10403024 | ||
4. Results | PMC10403024 | |||
4.1. Comparison of patients before and after training | hypertensive cerebral hemorrhage, cerebral hemorrhage, hemiplegia | CEREBRAL HEMORRHAGE | Twenty-five patients were enrolled in the experimental group, and 24 patients were enrolled in the control group. One patient in the control group had another sudden cerebral hemorrhage after enrollment, so he dropped out halfway. In the treatment group, the RMS difference in triceps crus passive extension before and a... | PMC10403024 |
5. Discussion | PMC10403024 | |||
5.1. Passive traction SEMG data of the triceps crus in both groups are presented in the third row of | tibialis anterior muscle, stroke | STROKE, CONTRACTION | Compared with the observation group, the SEMG of the treatment group was higher.The treatment group was 9.33 (88.44–7.47) and the control group was 4.17 (27.3–6.64).The difference between the 2 groups was statistically significant (The surface electromyography during passive traction of the triceps crus indicated trice... | PMC10403024 |
5.2. Limitations of the study | stroke, hemiplegic | STROKE | This study had the limitation of a small sample size of stroke patients from a single medical center, which does not provide a population-based representation of stroke patients. Additionally, we did not observe the recovery of foot dorsiflexion in patients with longer workouts. In the future, larger multicenter studie... | PMC10403024 |
6. Conclusions | tibialis anterior muscle resistance, hemiplegic | In conclusion, based on routine rehabilitation training, tibialis anterior muscle resistance training for hemiplegic patients can improve walking ability, reduce treatment costs, and facilitate home rehabilitation training, which is worthy of clinical promotion and application.This study has some limitations. For examp... | PMC10403024 | |
Abbreviations: | tibialis anterior muscle resistance, hypertensive cerebral hemorrhage hemiplegia | electromyographyroot mean squaresurface electromyographyThis study was supported by Qiaoliang Li.All patients provided written informed consent.This trial was approved by the Institutional Review Board of the Second People’s Hospital of Yibin City (Approval Number: 2021-008-01).The authors have no conflicts of interest... | PMC10403024 | |
References | PMC10403024 | |||
Objectives: | To ascertain the use of draining the thyroid bed following surgery. | PMC10187750 | ||
Methods: | pain | COMPLICATIONS | Fifty four patients who underwent total thyroidectomy were enrolled in the study between March 2021 and July 2022 and randomly allocated into 2 groups – a drain group and a no drain group. The hospital stay, operating time, post operative pain, post operative complications, cosmesis, and patient’s perspectives were com... | PMC10187750 |
Results: | Pain, pain | SCARRING, COMPLICATIONS | The mean duration of hospitalization was significantly shorter in the no drain group as compared to the drain group. The post operative pain, as assessed by the Mankoski Pain Scale (MPS) was significantly higher in the drain group than in the no drain group. The cosmetic evaluation undertaken using the Hollander Wound ... | PMC10187750 |
Conclusion: | pain | The routine drain placement following thyroidectomy places the patient at a disadvantage in terms of longer hospitalisation, increased post operative pain and poor cosmetic outcome. | PMC10187750 | |
Keywords: | pain |
While the routine use of drains following thyroidectomy remains a controversial and highly debated topic, the goal of our study was to test the hypothesis that thyroid surgeries performed without the routine usage of drains are more productive than those performed with drains as they decrease the duration of hospital ... | PMC10187750 | |
Methods | thyroid swelling | THYROTOXICOSIS, BLEEDING DIATHESIS | A prospective, randomized study was carried out on 54 patients for 18 months from March 2021 to July 2022. We included patients of both genders of all age groups in a euthyroid state with clinically proven and cytologically diagnosed thyroid swelling requiring surgical removal. The exclusion criteria were patients with... | PMC10187750 |
Statistical analysis | The data obtained was documented in a standard proforma, analyzed using the Microsoft Excel software and incorporated into Statistical Package for Social Sciences, version 22 (IBM Corp., Armonk, NY, USA). Continuous variables were shown as mean ± standard wherever appropriate. The results were considered as statistical... | PMC10187750 | ||
Results | SD | COMPLICATIONS | Based on selection criteria, 54 patients were enrolled in the study of which there was a definite female preponderance at 51 female and 3 male patients who underwent total thyroidectomy. The mean age of the patients was 44.8±6.1 (range 34-57 years). The mean duration of surgery was 68.1 minutes (SD ±9.3) in the drain g... | PMC10187750 |
Discussion | bleeding, postoperative pain, thyroid disease, pain, seroma, hematoma | BLEEDING, SCAR, THYROID DISEASE, WOUND INFECTION, COMPLICATION, SITE INFECTION, SEROMA, NECK HEMATOMA, SCARRING, HEMATOMA, COMPLICATIONS | The practise of general surgery has thyroid surgery at its core. Although the customary use of drains following thyroidectomy has been the subject of ongoing dispute, most surgical departments worldwide have a uniform practise of draining the thyroid bed following thyroidectomy. According to prevailing theory, suction ... | PMC10187750 |
Study limitation | pain | SCARRING, POSTOPERATIVE COMPLICATIONS | The small sample size of our study invariably limits the statistical significance of the results. No significant correlation could be established between the rates of postoperative complications and drains. Larger sample size and multicentric studies can be carried out to further evaluate the necessity of drain placeme... | PMC10187750 |
Acknowledgment | PMC10187750 | |||
References | PMC10187750 | |||
Background | neoplasia | NEOPLASIA, TYPE 2 DIABETES MELLITUS, CARDIOVASCULAR DISEASES | The high proportion of people with overweight and obesity has become a worldwide problem in recent decades, mainly due to health consequences, such as cardiovascular diseases, neoplasia, and type 2 diabetes mellitus. Regarding effective countermeasures, the digitization of health services offers numerous potentials, wh... | PMC10337343 |
Objective | weight loss | The purpose of this randomized controlled clinical trial was to evaluate the effectiveness of an interactive web-based weight loss program on anthropometric, cardiometabolic, and behavioral variables and to compare it with a noninteractive web-based weight loss program. | PMC10337343 | |
Methods | The randomized controlled trial included people who were aged between 18 and 65 years (mean 48.92, SD 11.17 years) and had a BMI of 27.5 to 34.9 kg/m | PMC10337343 | ||
Results | The intervention group showed significant improvements in anthropometric variables, such as body weight ( | PMC10337343 | ||
Conclusions | The interactive web-based health program was effective in reducing body weight and improving body composition in adults with overweight and obesity. However, these improvements were not associated with relevant changes in cardiometabolic variables, although it should be noted that the study population was predominantly... | PMC10337343 | ||
Trial Registration | German Clinical Trials Register DRKS00020249; https://drks.de/search/en/trial/DRKS00020249 | PMC10337343 | ||
International Registered Report Identifier (IRRID) | RR2-10.3390/ijerph19031393 | PMC10337343 | ||
Introduction | obesity, weight loss | OBESITY, ASSOCIATED DISEASE, DISEASES | The past decades have been characterized by a sharp increase in BMI [Although there are specific and evidence-based dietary and physical activity recommendations to prevent and treat obesity and its associated comorbidities, these behaviors often cannot be implemented and established in the long term. Systemic and envi... | PMC10337343 |
Methods | PMC10337343 | |||
Study Protocol | The main methodological points of this randomized controlled clinical trial with relevance to this paper are described below. A detailed description of the study methods can be found in the study protocol, which has already been published [ | PMC10337343 | ||
Study Design | weight loss, Universität zu Lübeck) [ | Study participants in the online questionnaire study “weight loss” who were living in southwest Germany (postcode area: 79) were additionally invited to the Department of Sport and Sport Science of the University of Freiburg for the clinical substudy [The study included intervention and control groups with automated ra... | PMC10337343 | |
Participants | RECRUITMENT | Participants aged 18 to 65 years in the online questionnaire study and residing in southwest Germany were additionally eligible to participate in the clinical substudy. The inclusion criteria for the clinical trial were a BMI of 27.5 to 34.9 kg/mRecruitment of the participants took place online and offline through vari... | PMC10337343 | |
Intervention | weight loss | STAGGERED | Both interventions were fully automated and without human involvement. The intervention group received an interactive web-based health program. The multimodal web-based health program could provide personalized intervention depending on health goals. The web-based health program was frozen for the evaluation to create ... | PMC10337343 |
Outcome Variables | BLOOD, SECONDARY | The primary outcome of the study was body weight. This was measured using the validated bioelectrical impedance scale Seca mBCA 515 (Seca GmbH & Co KG) [In addition, behavioral and physiological variables were defined as secondary outcomes. In the behavioral domain, dietary and physical activity behaviors were recorded... | PMC10337343 | |
Data Analysis | PBC | R (Version 4.1.3; R Core Team) and R Studio (Version 2021.09.1; Posit PBC) were used for statistical analysis and creation of the graphs. Statistical analysis of all variables was performed with robust linear mixed models using the R packages lme4 [Per-protocol (PP) and intention-to-treat (ITT) analyses were performed.... | PMC10337343 | |
Ethical Considerations | MINOR | This study followed the principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of the University of Freiburg on July 25, 2019 (vote number: 237/19). A clinical pilot study was conducted (vote number: 409/18, DRKS00016512), resulting in minor changes to the study protocol. These change... | PMC10337343 | |
Results | PMC10337343 | |||
Participants | RECRUITMENT, RECRUITMENT | Recruitment of participants took place from January 2020 to July 2020. During this period, 257 interested individuals registered for the clinical substudy. After screening (telephone interview and preliminary examination), 153 subjects were included in the study, and they completed the baseline measurement. There were ... | PMC10337343 | |
Discussion | loss of fat-free mass, muscle mass, weight loss, fat-free mass | The main finding of this study was that the interactive web-based health program focusing on dietary energy density showed positive effects on body weight, fat mass, and waist circumference. These effects were significantly more pronounced in the intervention group than in the control group with only web-based knowledg... | PMC10337343 | |
Abbreviations | high-density lipoproteinlong version of the International Physical Activity Questionnaireintention to treatlow-density lipoproteinper protocolSection for Health Services Research and Rehabilitation Research | PMC10337343 | ||
Data Availability | The data sets generated during or analyzed during this study are available from the corresponding author on reasonable request. | PMC10337343 | ||
1. Introduction | TBI, traumatic brain injury | This pilot study assessed the feasibility of using SwapMyMood, a smartphone application supporting evidence-based strategies for emotion regulation and problem-solving as a supplement to conventional care for military service members and veterans (SM/Vs) experiencing chronic symptoms of mild traumatic brain injury (mTB... | PMC9915093 | |
2. Materials and Methods | The study protocol was approved for use of human subjects by the Shepherd Center Institutional Review Board. Clinicians were directly involved in the study design, administration, and data collection. Participants, intervention providers, and those assessing the outcomes were not blinded.Feasibility studies are usually... | PMC9915093 | ||
2.1. Intervention | SwapMyMood was developed following principles of user-centered design, engaging stakeholders at each stage of development as previously described [ | PMC9915093 | ||
2.2. Participants and Procedures | stroke, cognitive functioning, brain injury | STROKE | A total of 8 participants were recruited from the SHARE Military Initiative (SHARE) intensive outpatient program at Shepherd Center in Atlanta, Georgia. SHARE is a donor-funded program that provides comprehensive, intensive interdisciplinary outpatient rehabilitation care to military SM/Vs experiencing symptoms of brai... | PMC9915093 |
2.3. Measures | Participants completed assessments pre- and post-intervention. Pre-measures were recorded following a 2-week evaluation that was completed as part of the clinical program; post-measures were completed following a 6-week treatment period (Goal Attainment Scaling (GAS), an individualized outcome measure involving goal se... | PMC9915093 | ||
2.4. Data Analysis | PTSD | Participant characteristics, such as age, race, and gender, are presented at an individual-patient level. Outcomes are described using counts/percentages for categorical variables and means/standard deviations for scale variables. While under-powered, initial comparisons between groups were conducted using the χ2/exact... | PMC9915093 | |
4. Discussion | TBI, brain injury | Results of this pilot feasibility study suggest SwapMyMood may be an acceptable addition to the use of paper manuals to support SM/Vs with mTBI and co-occurring psychological conditions in using the executive functioning strategies taught in the Executive Plus/STEP Program and should be studied in an adequately powered... | PMC9915093 | |
4.1. Limitations | The primary limitation of this study is the small sample size, which limits statistical analysis and the generalizability of findings. While both groups demonstrated post-intervention gains and appear statistically comparable, it is unknown whether differences may be detectable in a larger sample. While statistically n... | PMC9915093 | ||
4.2. Future Directions | A central aim of this study was to assess whether SM/Vs with co-occurring psychological conditions would find SwapMyMood acceptable and useful. While most experimental group participants rated the app highly on the SUS, one participant did not. Participant feedback will be considered in refinements to the current versi... | PMC9915093 | ||
5. Conclusions | SwapMyMood may be a clinically effective supplemental tool for supporting executive function in SM/Vs with mTBI and co-occurring psychological conditions and should be studied in a larger, controlled trial with a more diverse cohort, using methodology similar to that used in this feasibility study. | PMC9915093 | ||
Author Contributions | Conceptualization, T.W. and J.M; Methodology, R.G., J.M. and T.W.; Validation, R.G. and T.W.; Formal Analysis, R.G., J.M. and T.W.; Investigation, R.G.; Data Curation, R.G.; Writing—Original Draft Preparation, R.G. and T.W.; Writing—Review and Editing: T.W., J.M. and R.G.; Project Administration, T.W. and J.M.; Funding... | PMC9915093 | ||
Institutional Review Board Statement | The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board at Shepherd Center (project number 678, protocol version 3.1.21 approved on 3 March 2021). | PMC9915093 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC9915093 | ||
Data Availability Statement | The raw data supporting the conclusions of this article will be made available by the authors without undue reservation. | PMC9915093 | ||
Conflicts of Interest | The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. | PMC9915093 | ||
KEYWORDS | PMC10269780 | |||
INTRODUCTION | Crohn’s disease, IBD, ulcerative colitis, UC | INTESTINAL INFLAMMATION, INFLAMMATORY BOWEL DISEASE, REMISSION, ULCERATIVE COLITIS | Inflammatory bowel disease (IBD), mainly defined as either ulcerative colitis (UC) or Crohn’s disease (CD), is a chronic and relapsing intestinal inflammation involving various factors and an abnormal immune response (For decades, fecal microbiota transplantation (FMT), the administration of a fecal suspension obtained... | PMC10269780 |
RESULTS | PMC10269780 | |||
Beneficial outcomes of FMT. | gastrointestinal complaints, UC | ULCERATIVE COLITIS, ADVERSE EVENTS, ADVERSE EVENT, ADVERSE EVENT, REMISSION, EVENTS | Between June 2016 and June 2019, 22 patients with active UC were recruited and assessed for eligibility. Enrolled patients received capsulized FMT treatment and completed the final follow-up at week 12. During the follow-up visits, one patient failed the screening process and was thus excluded. The clinical trial proto... | PMC10269780 |
Alterations in gut microbiota after FMT. | UC | Bacterial α diversity was assessed by determining richness (observed and Chao1), Shannon diversity, and Pielou’s evenness based on 16S V3-V4 sequencing. As expected, the bacterial α diversity, observed richness (Similarly, both richness indices were significantly higher in donor samples than in baseline samples of pati... | PMC10269780 | |
Enrichment of beneficial bacteria associated with the clinical remission after FMT accompanied the decrease in levels of opportunistic pathogens. | UC | REMISSION | UC patients who achieved clinical remission exhibited efficient and durable changes in their gut microbiota after FMT. Based on 16S V3-V4 sequencing, gut bacterial richness was increased in the clinical remission (Rm) group and was comparable to that of donors during the follow-up visits after FMT. In contrast, the ric... | PMC10269780 |
Shotgun metagenomic analyses confirmed the signatures associated with clinical remission. | REMISSION | To further reveal the gut microbial signatures associated with clinical remission, the microbial data obtained after shotgun metagenomic analyses of week 0 Rm (W0_Rm) and W4_Rm and week 0 NRm (W0_NRm) and W4_NRm were analyzed using the paired Wilcoxon test. A total of 5,466 species were annotated using kraken2, of whic... | PMC10269780 | |
Metabolomic profiling of UC patients achieving remission. | metabolic alterations | REMISSION | Global metabolomic analysis of serum samples revealed metabolic alterations and metabolites associated with clinical remission after capsulized FMT administration. As visualized in the partial least-squares discriminant analysis (PLS_DA) ordination, the metabolomic profiles of patients were shifted after FMT treatment ... | PMC10269780 |
Interomic correlations between gut microbes and metabolites. | Procrustes analysis demonstrated the strong cooperative relationships between the gut microbiota and KEGG modules (MInteromic correlations between gut microbes and metabolites. (A) Procrustes analysis of gut microbial species and serum metabolites; (B) proportion of the total variations in serum metabolomes for differe... | PMC10269780 | ||
DISCUSSION | ulcerative colitis, UC | DISEASE, REMISSION, ULCERATIVE COLITIS | In this study, we explored the clinical outcomes of capsulized FMT treatment in patients with active UC. We also performed a general analysis of the gut microbiota and serum metabolites to identify specific taxonomic, functional, and metabolite changes associated with clinical outcomes after FMT. Capsulized FMT could i... | PMC10269780 |
MATERIALS AND METHODS | PMC10269780 | |||
Study design. | UC | We conducted a single-arm pilot clinical trial by enrolling 22 patients with active UC between June 2016 and June 2019 at Zhongshan Hospital in Xiamen University. Nine donors were included in the study, and their stool was extracted and filled into capsules. To increase microbial diversity, every patient randomly recei... | PMC10269780 | |
Withdrawal criteria. | Patients could withdraw from the study at any time. To ensure the reliability of data, patients were informed that they needed to contact clinicians before withdrawal and provide reasons for leaving. | PMC10269780 |
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