title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
|---|---|---|---|---|
PPG measurement method | inferior vena cava, TIPS | TIPS was established under local anesthesia using a transjugular approach. 4-Fr pigtail catheters were placed in the right atrium, inferior vena cava (at the level of the hepatic vein), and portal vein (where the spleen and superior mesenteric vein converge) to measure the pressure before and after stent placement. For... | PMC10502141 | |
Statistical analysis | OHE | REGRESSION | The statistical analysis was performed by SPSS 26.0 (SPSS Inc, Chicago, USA) and R 4.0.3 (Institute of Statistics and Mathematics). The univariate or multivariate analysis was conducted at a test level of 0.01 or 0.05, respectively. Means of continuous variables were calculated and compared using Mann–Whitney U tests o... | PMC10502141 |
Ethical approval | The clinical data were approved by the Ethics Committee of Beijing Shijitan Hospital Affiliated to Capital Medical University. Patients sign informed consent. | PMC10502141 | ||
Results | PMC10502141 | |||
Constructing a nomogram prediction model for OHE after TIPS | OHE | Based on multivariate analysis, age, ICG-R15, percentage of PPG decline, creatinine, and blood ammonia were identified as independent risk factors for OHE after TIPS. By using rms package of R software, independent factors were incorporated into a nomogram prediction model for OHE after TIPS. The expected probability o... | PMC10502141 | |
The nomogram had a higher predictive power for OHE after TIPS in the training cohort | OHE | In the training cohort, this nomogram model achieved higher prediction accuracy than other conventional models. The C-index of our nomogram was 0.828 (95% CI 0.761–0.896), significantly higher than that of Child–Pugh score (0.665; 95% CI 0.576–0.755) or MELD score (0.657, 95% CI 0.559–0.755) (Fig. Prediction accuracy o... | PMC10502141 | |
The nomogram had a higher predictive power for OHE after TIPS in the validation cohort | OHE | Our nomogram model was accurate in predicting OHE after TIPS in the validation cohort, with a C-index of 0.8464 (95% CI 0.7404–0.9524), higher than that of Child–Pugh score (0.6569, 95% CI 0.5129–0.8009) or MELD score (0.6616, 95% CI 0.5156–0.8076) (Fig. | PMC10502141 | |
DCA curve comparison of nomogram and conventional models for OHE after TIPS prediction accuracy | The DCA curves indicated that our nomogram prediction model was more valuable than MELD score or Child–Pugh score (Fig. In ( | PMC10502141 | ||
Discussion | TIPS, OHE, liver function injury | REGRESSION, POSTOPERATIVE COMPLICATIONS | With continuous improvement of hardware facilities and technical concepts, effects of TIPS on PHT therapy have becoming more and more remarkable, however, its postoperative complications remain challenging. For example, HE caused by biochemical disturbance of brain functions as a result of liver function injury and por... | PMC10502141 |
Acknowledgements | We wish to particularly acknowledge the patients enrolled in this study for their participation. | PMC10502141 | ||
Author contributions | All authors contributed to the study conception and design. Data collection and analysis were performed by L.Z., J.-t.W., Z.-d.Y., Z.-h.F., Y.-f.W., Y.Z., C.-b.D., X.-q.W., T.C., M.-m.M., L.B., S.-b.C., F.-q.L., L.W. The first draft of the manuscript was written by Y.L. and all authors commented on previous versions of... | PMC10502141 | ||
Funding | This work was supported by the National Natural Science Foundation of China General Program (Grant no. 81871461). | PMC10502141 | ||
Data availability | The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. | PMC10502141 | ||
Competing interests | The authors declare no competing interests. | PMC10502141 | ||
References | PMC10502141 | |||
Background | mental disorders, depression, anxiety, Common mental disorders | Common mental disorders are the leading cause of workplace absences. The Prevail intervention programme aims to reduce stigma and to educate staff and managers about evidence-based low intensity psychological interventions for common mental disorders (depression, anxiety, stress, and distress). Prevail is innovative in... | PMC10334530 | |
Methods | A two-armed cluster randomised control trial (RCT) evaluated the effectiveness of Prevail. Employees ( | PMC10334530 | ||
Results | Prevail was evaluated highly favourably by both the staff and their managers. Prevail produced significant reductions in self-stigma and anticipated stigma due to mental health difficulties. Crucially, sickness absence was significantly reduced by the Prevail Intervention. | PMC10334530 | ||
Discussion | Prevail achieved its goals of producing a palatable and engaging intervention that altered staff’s attitudes and stigmatic beliefs related to mental health and, crucially, produced a strong reduction in work-pace absenteeism. As the Prevail programme is aimed at common mental health problems and was not specialised to ... | PMC10334530 | ||
Trial Registration | mental disorder | ISRCTN12040087. Registered 04/05/2020. 10.1186/ISRCTN12040087. A full protocol for the randomised control trial was published: Gray NS, Davies H, Snowden RJ: Reducing stigma and increasing workplace productivity due to mental health difficulties in a large government organization in the UK: a protocol for a randomised ... | PMC10334530 | |
Keywords | PMC10334530 | |||
Background | CMDs, depression, anxiety, Common mental disorders | ADULT DISEASE | Common mental disorders (CMDs, i.e. anxiety and depression) contribute around 16–17% of the burden of adult disease in the UK [ | PMC10334530 |
Previous intervention programmes | cognitive behavioural therapies | Most previous work aiming to look at the effects of therapies for CMDs on employment-related variables (e.g., sickness absence, return to work) have looked at standard treatments for CMDs such as cognitive behavioural therapies or medication. While such treatments have the expected (positive) effect on symptom reductio... | PMC10334530 | |
Prevail | CMD, presenteeism | Prevail is a multi-faceted programme aimed at reducing sickness absence and presenteeism due to CMDs. It involves two psychological interventions, both provided via group based intervention programmes. The first (Prevail Staff Intervention) is for all employees within the organization and its aims are to improve knowle... | PMC10334530 | |
Aims and hypotheses | Our original aims were to: (1) measure mental health literacy (and mental health stigma in particular) before and after the intervention, (2) compare sick leave in the 12 months pre- and post-intervention, and (3) to measure quality of life, presenteeism, and current mental health 12 months post intervention [ | PMC10334530 | ||
Methods | The setting was the Driver and Vehicle Licencing Agency (DVLA). The DVLA is the executive agency part of the Department for Transport. DVLA maintain the registration and licensing of drivers and vehicles in Great Britain. It employs around 6,000 people mainly at its head office in Swansea, Wales, UK. All participants i... | PMC10334530 | ||
Participants | Sixty-seven managers across four divisions of the DVLA, stratified by division [Information Technology Services (ITS), the Contact Centre (CC), Casework and Enforcement Group (CAEG), and Input Services Group (ISG)] were chosen for the study. These were then randomised (using a random number sequence) into the two arms ... | PMC10334530 | ||
Power and statistical analysis | Our initial aim (see [A | PMC10334530 | ||
Prevail intervention | depression, CMD, anxiety | DISORDER, DISORDERS | The Prevail intervention programmes were conceptualised and written by two of the authors (NSG, RJS) who also served to train the trainers that delivered the Prevail Staff Intervention and to deliver the Prevail Managers intervention. NSG is a Consultant Clinical and Forensic Psychologist with over 25 years of experien... | PMC10334530 |
Delivery of prevail | The Prevail Intervention programme consists of a series of nine modules taking a mainly didactic approach to learning, but with many interactive components and case study discussions to enhance participant engagement. The modules consist of lectures on specific topics (e.g. Module 5 “Stress and Emotional Stress”) that ... | PMC10334530 | ||
Results | PMC10334530 | |||
Part 1. Perceptions of the prevail training | depression, anxiety | Overall, 492 people completed the evaluation of the Prevail intervention. No demographic information was taken. A summary of the quantitative results for the Prevail Staff Intervention is given in Fig. Importantly, three questions in the quantitative evaluation aimed to examine if participants felt the intervention had... | PMC10334530 | |
Part two. Changes in mental health literacy | The descriptive statistics for the sample, stratified by condition (active vs. control) and wave (pre-assessment or Wave 1 vs. post-assessment or Wave 2) are presented in Table
Demographic Information on RCT participantsThe psychometric properties for the SASS scales were highly similar to a previous report of the pro... | PMC10334530 | ||
Part three. Sickness absence | PMC10334530 | |||
Statistical methods | mental disorder | Chi-square analysis was performed to compare the active and control arms on demographic characteristics including age, gender, and directorate. Chi-square analysis and unadjusted odds ratios (OR) with 95% confidence intervals (95% CI) were used to compare the treatment arms on the number of “all sickness” and “mental d... | PMC10334530 | |
Statistical results | The results of the demographic variable comparisons are presented in Table
Demographics and chi-square analysis for the participants in the RCT for sickness absenceFor the analysis of summary sickness absences, there was a significantly higher proportion of “all sickness” absence days in the control group during the s... | PMC10334530 | ||
Discussion | In order to evaluate the Prevail intervention we assessed, (1) whether the people who underwent Prevail thought that the intervention achieved its aims, (2) whether Prevail produced changes in people’s mental health literacy (including stigma reduction), and (3) whether Prevail changed their ability to work (reduced ab... | PMC10334530 | ||
Evaluation of the prevail intervention | Prevail Staff Intervention was administered to staff via a one-day group intervention. Most participants evaluated the duration and pace of the intervention as appropriate and that they were able to understand the Prevail content. Crucially, they also thought that they would be able to improve their own mental health, ... | PMC10334530 | ||
Changes in mental health literacy | The Prevail Intervention led to clear reductions in levels of self-stigma and anticipated stigma. These two scales are those most strongly associated with mental health [ | PMC10334530 | ||
Changes in sickness absence | anxiety | DISORDERS, DISEASE, FLU | Producing an intervention that is valued by the workforce and which is able to change people’s attitudes and intentions to seek help is a good achievement. However, actually being able to change people’s future behaviour is a far more difficult task [While the results of the Prevail intervention appear robust there are... | PMC10334530 |
Limitations to the RCT | LEAKAGE | The main limitation to the study were the unexpected differences in baseline levels of sickness absence between the two arms of the study (see discussion above). The study was also curtailed in some of its aims due to the onset of restrictions due to the COVID-19 pandemic that severely altered work practices and limite... | PMC10334530 | |
Acknowledgements | Thanks to all members of the project team at the DVLA for their help with this project and for the support we received from the DVLA Executive Board who approved and supported the Prevail Intervention programme and three-stage evaluation. We are particularly grateful to Louise White and Andrew Falvey as Executive Direc... | PMC10334530 | ||
Authors’ contributions | The conception of the Prevail programme was completed by NSG in collaboration with HD. NSG and RJS wrote the Prevail intervention programme. HD arranged for a cross-section of DVLA staff to give feedback on draft versions of the psychological intervention and gave advice on practical implementation of the programme to ... | PMC10334530 | ||
Funding | The development of Prevail, its implementation to the DVLA, and the costs of the RCT were funded by the DVLA via a research grant to Swansea University (Ref number: PSC1046). The funders helped in the implementation of the RCT via selecting appropriate managers and their teams, randomising these managers/teams to the a... | PMC10334530 | ||
Data Availability | mental disorder | The datasets generated during this research and/or analysed following completion of the current study are stored in a publicly available repository (Mendeley). Snowden, Robert (2022), “Reducing stigma and increasing workplace productivity due to mental health difficulties: A randomised control treatment trial (RCT) of ... | PMC10334530 | |
Declarations | PMC10334530 | |||
Ethical approval and consent to participate | All methods were carried out in accordance with relevant guidelines and regulations (e.g., the Declaration of Helsinki). This trial has received ethical approval by Ethics committee of Swansea University, 25/09/2019 Ref: 1521. Participants selected for the Prevail intervention programme undertook this programme as part... | PMC10334530 | ||
Consent for publication | Not applicable. | PMC10334530 | ||
Competing interests | NSG and RJS are the authors of the Prevail intervention and may receive commission or financial reward for the future use of this programme. The other authors have no competing interests. | PMC10334530 | ||
References | PMC10334530 | |||
The present study | personality traits | SECONDARY | The goal of this study was to test the effects of a 7-week digital self-control intervention to increase physical activity using a two-arm randomized controlled trial. The self-control treatment group showed greater increases in self-reported physical activity (MET’s) than the comparison group. Both groups significantl... | PMC10466994 |
Method | This study has been approved by the University’s Institutional Review Board at Brandeis University and the protocol has been registered at ClinicalTrials.gov (CT04522141) and is published ( | PMC10466994 | ||
Participants | A total of 86 middle-aged adults were enrolled in the study between October 2020 and April 2021. Participants were recruited from across the US, with a majority in the Northeast, by posting advertisements on public boards and online. Advertisements specified: “Do you want to be more active, but find yourself making exc... | PMC10466994 | ||
Study design and procedure | BLIND | This study used a two-arm randomized controlled trial design with a pretest (baseline), weekly assessments at the end of every week (weeks 1–7), a posttest (week 8), and a follow-up assessment (week 12). Participants were randomly assigned to one of the two conditions: the treatment group or the comparison group. The a... | PMC10466994 | |
Self-control treatment group | The treatment group used the MindHike coaching application, which supports and guides people who would like to train their self-control with the help of a digital coach. The app delivered the same dialogs to all participant in the treatment group. There was no bi-directional communication, but participants clicked on p... | PMC10466994 | ||
Comparison group | The comparison group used a minimal app version across the eight study weeks, which sent them two daily reminders. At customized times in the morning, they were reminded to wear the Fitbit and at customized times in the evening, they were reminded to sync their step data with the Fitbit app and to charge their Fitbit d... | PMC10466994 | ||
Primary outcome measures | The study included Qualtrics online questionnaires at the pretest, weekly assessments (weeks 1–7), a posttest (week 8), and a follow-up assessment (week 12). | PMC10466994 | ||
Self-control | Self-control was assessed in two ways. First, we assessed overall self-control at pretest, at posttest, and follow-up assessment using the Brief Self-control Scale (BSCS; Second, to measure weekly self-control, we asked participants to indicate to what extent the same 13 items from the BSCS applied to them with respect... | PMC10466994 | ||
Self-reported physical activity (MET’s) | Self-reported physical activity was assessed at pretest, posttest, and follow-up using the short version of the International Physical Activity Questionnaire (IPAQ; | PMC10466994 | ||
Objectively assessed physical activity | Fitbit Charge 4 activity trackers ( | PMC10466994 | ||
Daily steps | As there were likely times when participants walked without wearing their Fitbit device, we only included days with more than 500 steps as valid days in our analyses. This is in line with prior studies using step data ( | PMC10466994 | ||
MVPA | Daily steps and MVPA can be correlated, but MVPA can pick up on activity that is more strenuous than regular walking. Fitbit categorizes active time into four categories: sedentary, lightly active, fairly active, and very active. In this study, MVPA was calculated by adding up fairly active and very active minutes each... | PMC10466994 | ||
Secondary outcome measures | PMC10466994 | |||
Conscientiousness | At pretest, posttest, and follow-up assessment, participants completed the 60-item BFI-2 to assess conscientiousness ( | PMC10466994 | ||
Covariates | Age, sex (0 = female, 1 = male), education in years, race (0 = White, 1 = Non-White), self-reported functional health (SF-36( | PMC10466994 | ||
Data analysis | Details on the power analyses are reported in We used longitudinal multilevel models and the lme4 package in R (To test if participants showed significant changes in our outcome measures, we tested the main effects of time using multilevel models. In additional multilevel models, we tested if there was differential cha... | PMC10466994 | ||
Results | Randomization check and attrition analyses are reported in | PMC10466994 | ||
Association between changes in self-control and changes in physical activity | We tested a Time by Change in Self-control interaction to examine if participants who showed greater increases in self-control were better able to increase their physical activity across time. The results suggest that participants who showed greater increases in self-control showed greater increases in MET’s (Associati... | PMC10466994 | ||
Discussion | Three important findings emerged from the present study. First, the results suggest significant overall increases in physical activity and self-control in both conditions. Also, both groups maintained their levels of physical activity and self-control until 4 weeks after the end of the intervention. Second, participant... | PMC10466994 | ||
Limitations and future directions | Based on the present findings, it is not entirely clear which micro interventions are most effective in changing self-control and physical activity. Future research is needed to disentangle the specific active ingredients of the intervention. The results on increasing self-control and physical activity in the compariso... | PMC10466994 | ||
Conclusion | This study constitutes the first to test whether a digital self-control coaching intervention has an effect on physical activity. The results suggest that a digital intervention targeting self-control can help people increase their MET levels for physical activity. Also, individuals with higher levels of conscientiousn... | PMC10466994 | ||
Supplemental Material | PMC10466994 | |||
sj-docx-9-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.Supplemental material, sj-docx-9-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-pdf-1-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-pdf-1-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-pdf-2-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-pdf-2-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-pdf-3-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-pdf-3-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-pdf-4-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-pdf-4-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-sav-5-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-sav-5-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-sav-6-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.sj-sav-6-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
sj-sav-7-hpq-10.1177_13591053231166756 – Supplemental material for Effects of a digital self-control intervention to increase physical activity in middle-aged adults | Click here for additional data file.j-sav-7-hpq-10.1177_13591053231166756 for Effects of a digital self-control intervention to increase physical activity in middle-aged adults by Mirjam Stieger, Mathias Allemand and Margie E Lachman in Journal of Health Psychology | PMC10466994 | ||
References | PMC10466994 | |||
Methods | Autoimmune and Autoinflammatory Disorders, Sarah Alice, T1D | AUTOIMMUNE DISORDERS, TYPE 1 DIABETES | Edited by: Sarah Alice Long, Benaroya Research Institute, United StatesReviewed by: Howard Davidson, University of Colorado, United States; Helena Reijonen, City of Hope National Medical Center, United StatesThis article was submitted to Autoimmune and Autoinflammatory Disorders: Autoimmune Disorders, a section of the ... | PMC9933867 |
Results | Higher GADA, GADA subclasses, GAD | PMC9933867 | ||
Conclusion | Patients with DR3DQ2 haplotype had a distinct early cellular immune response to GAD-alum injections into the lymph node, and predominant GAD | PMC9933867 | ||
Introduction | T1D, chronic disorder | CHRONIC DISORDER, DISEASE PROGRESSION, ADVERSE EVENTS, DISEASE, TYPE 1 DIABETES | Type 1 diabetes (T1D) is a chronic disorder requiring lifelong treatment. Despite intensive treatment, the disease causes substantial morbidity and mortality. Several clinical intervention trials with different approaches to delay or halt disease progression have shown limited efficacy, sometimes accompanied with adver... | PMC9933867 |
Materials and methods | PMC9933867 | |||
Study design | diabetes | TOLERANCE, DIABETES | DIAGNODE-2 study was a two-arm, multicenter, randomized, double-blind, placebo-controlled trial (NCT03345004) performed at 18 diabetes clinics in the Czech Republic, the Netherlands, Spain, and Sweden as described before (Three intralymphatic injection with 4 μg GAD-alum (Diamyd Medical, Stockholm, Sweden) on days 30, ... | PMC9933867 |
Blood samples | For the immunological analysis, blood and serum were collected at all visits. Samples were drawn during the morning hours, and peripheral blood mononuclear cells (PBMCs) were isolated within 24 hours using Leucosep (Greiner Bio One), according to the manufacturer’s instructions at Linköping University, Sweden. | PMC9933867 | ||
GAD autoantibodies and IgG subclasses | GAD autoantibodies | Serum GAD autoantibodies (GADA) levels were assessed by means of enzyme-linked immunosorbent assay (ELISA) by Synlab Pharma Institute (Munich, Germany).GADA IgG 1, 2, 3, and 4 subclasses were measured by radio-binding assays using IgG subclass-specific biotin-labelled mouse-anti-human monoclonal antibodies bound on Str... | PMC9933867 | |
Lymphocyte proliferation assay | PROLIFERATIVE | Proliferative response was analyzed in PBMCs cultured in triplicates in AIM-V medium with β-mercaptoethanol at 37°C in 5% CO | PMC9933867 | |
Cytokine secretion assay | Cytokines were quantified both in serum samples and in PBMCs supernatants. PBMCs were cultured in AIM-V medium with β-mercaptoethanol for 7 days at 37°C in 5% CO | PMC9933867 | ||
Statistics and software analysis | Immunological data was presented as median with 95% CI following non-normal distribution, and nonparametric tests were applied. For determining differences between groups, the Mann-Whitney test was used, and Wilcoxon test was applied for differences within groups. A probability level of < 0.05 was considered statistica... | PMC9933867 | ||
Results | PMC9933867 | |||
Immune response in GAD-alum treated patients | PROLIFERATION | GADA levels increased in GAD-alum treated patients at 2 months, after the first injection, and remained higher through the study compared to the placebo group (Immune response from day 1 to 15 months in GAD-alum (smooth line, n=56) and Placebo (dashed line, n=52) individuals. GADFurther stratification of the GAD-alum a... | PMC9933867 | |
Changes associated to the DR3DQ2 haplotype | Comparison of the immune response in individuals who received GAD-alum stratified according to the DR3DQ2 haplotype showed that GADImmune response from day 1 to 15 months in GAD-alum treated patients with (black, n=29) and without (light blue, n=27) DR3DQ2 haplotype. | PMC9933867 | ||
Immune response in relation to clinical outcome | To search for immune surrogate markers of clinical efficacy, we looked for the association between remaining C-peptide secretion at 15 months (Immune responses in GAD-alum treated patients in relation to Clinical outcome. Patients who received GAD-alum were stratified into Good Responders (GR, n=23, loss < 30% AUC) and... | PMC9933867 | ||
Discussion | T1D | DISEASE, TYPE 1 DIABETES, OTHER AUTOIMMUNE DISEASE | The DIAGNODE-2 study constituted the first placebo-controlled trial in which an autoantigen was administrated into the lymph nodes of patients with Type 1 diabetes, and immunological changes observed in GAD-alum treated patients with respect to placebo have not been previously described. Modifications following therapy... | PMC9933867 |
Data availability statement | The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. | PMC9933867 | ||
Ethics statement | The studies involving human participants were reviewed and approved by the relevant regulatory authorities and research ethics boards of the participating sites and countries. Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin. | PMC9933867 | ||
Author contributions | RC designed the experiments. SP-M, FD, and PA performed experiments. SP-M and HB analyzed the data. SP-M and RC interpreted the results and wrote the manuscript. JL conceived DIAGNODE-2 study, recruited, and followed patients. All authors contributed to the article and approved the submitted version. | PMC9933867 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.