title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Conflicts of Interest | The authors declare no conflicts of interest. | PMC10780457 | ||
References | BLOOD | Study design. S1, S2, S3, S4—study series; LH–TL—live high–train low protocol; DAA—D-aspartic acid.Blood serum testosterone (Training program during the experiment.Selected hematological variables and area under the curve for testosterone (AUC T), free testosterone (AUC fT), cortisol (AUC C), and luteinizing hormone (A... | PMC10780457 | |
1. Introduction | abortion, menstrual abnormalities, ±, uterine adenomyosis, reduced menorrhagia, infertility, dysmenorrhea, adenomyosis, muscular hypertrophic, menorrhagia, Adenomyosis | ENDOMETRIOSIS, OBSTETRICAL COMPLICATIONS, DYSMENORRHEA, ADENOMYOSIS, SECONDARY, MENORRHAGIA, ADENOMYOSIS | Beneficial and detrimental effect of surgical adenomyomectomy is still controversial in infertile women with severely diffuse adenomyosis. The primary objective of this study was to assess whether a novel method of fertility-preserving adenomyomectomy could improve pregnancy rates. The secondary objective was to evalua... | PMC10063302 |
2. Materials and methods | PMC10063302 | |||
2.1. Study participants | adenomyosis, ovulation disorder, infertility, dysmenorrhea | EXCESSIVE MENSTRUAL FLOW, SECONDARY INFERTILITY, ADENOMYOSIS, DYSMENORRHEA, BLOCKED FALLOPIAN TUBES, IRON DEFICIENCY ANEMIA | A prospective clinical trial was conducted between December 2007 and September 2016 at Dongguk University Ilsan Hospital, South Korea. Fifty study participants were selected based on the following criteria: patients diagnosed with diffuse adenomyosis via pelvic ultrasonography and magnetic resonance imaging (MRI); pati... | PMC10063302 |
2.2. Ethical approval | The Institutional Review Board of Dongguk University Ilsan Hospital approved this study (IRB No. 2007-24). Written informed consent was obtained from all participants. All study procedures were performed in accordance with the guideline of Act on Bioethics and Sefety of South Korea. This study has been registered in Cl... | PMC10063302 | ||
2.3. Adenomyomectomy procedure | bleeding, cancer, dysmenorrhea, adenomyosis, menorrhagia | BLEEDING, CANCER, DYSMENORRHEA, ADENOMYOSIS, REMISSION, MENORRHAGIA, COMPLICATIONS | We designed a novel operative procedure consisting of the following methods. First, an initial measurement of the adenomyotic lesion was made using ultrasonography and MRI (Fig. Schematic (a–e) and actual images (f–j) of the adenomyomectomy procedure. (a & f) A T-shaped incision is made on the uterine wall. (b & g) The... | PMC10063302 |
2.4. Antepartum management | PRETERM BIRTH | After 6 months of adenomyomectomy, participants could try to conceive and the method of pregnancy was left to the patients’ preference, including natural means or ART.In antepartum, to prevent preterm birth and uterine rupture during pregnancy, progestin treatment was provided to all patients for up to 34 weeks of gest... | PMC10063302 | |
2.5. Statistical analysis | ±, SD | The data are presented as mean ± SD or median with ranges. Comparison of clinical outcomes before and after surgery was performed using the paired | PMC10063302 | |
3. Results | PMC10063302 | |||
3.1. Clinical and surgical outcomes | ±, cancer, SD, dysmenorrhea, premature ovarian insufficiency, NRS | PREMATURE OVARIAN INSUFFICIENCY, CANCER, DYSMENORRHEA | The clinical characteristics and surgical features of the patients are summarized in Table Clinical and surgical features of enrolled patients.Values are presented as mean ± SD, n (%) and median (range).POI = premature ovarian insufficiency.Six months postoperatively, all patients obtained symptom relief of dysmenorrhe... | PMC10063302 |
3.2. Pregnancy outcomes | Pregnancy outcomes are shown in Table Pregnancy outcomes in infertile patients following adenomyomectomy.Data are n (%).Two cases of twin pregnancies and 1 patient who successfully gave birth twice.Flowchart reporting the pregnancy outcome of study subjects after adenomyomectomy. | PMC10063302 | ||
4. Discussion | ovarian insufficiency, ureter fistula, postoperative ovarian insufficiency, infertility, dysmenorrhea, adenomyosis, Pelvic pain, premature ovarian insufficiency, menorrhagia, hematoma, adenomyotic lesion, comorbid diseases | ENDOMETRIOSIS, PREMATURE OVARIAN INSUFFICIENCY, RECURRENCE, ABNORMAL UTERINE BLEEDING, POSTOPERATIVE COMPLICATIONS, PATHOLOGICAL PROCESS, UTERUS, COMPLICATIONS, DYSMENORRHEA, ADENOMYOSIS, MENORRHAGIA, HEMATOMA, DISEASES, UTERUS | The present study evaluated the clinical efficacy of conservative debulking surgery in infertile patients with severely diffuse adenomyosis. Our novel method of fertility-preserving adenomyomectomy resulted in increased pregnancy rates with successful outcomes, as well as symptom relief of dysmenorrhea and menorrhagia.... | PMC10063302 |
Acknowledgments | Jimin J. are greatly acknowledged for helping the preparation of the manuscript. | PMC10063302 | ||
Abbreviations: | adenomyosis | ADENOMYOSIS | assisted reproductive technologycancer antigen 125gonadotropin-releasing hormone agonistin vitro fertilization and embryo transfermagnetic resonance imagingnumeric rating scaleTrial registration: This study has been registered in Clinical Research Information Service, Republic of Korea (KCT0004135).The authors have no ... | PMC10063302 |
References | PMC10063302 | |||
Abstract | Shared last authorship. | PMC10441870 | ||
Background | PD, cancer | CANCER | Psychological distress (PD) and fear of cancer recurrence (FCR) are common consequences of surviving cancer. Online self-help training could help many cancer survivors deal with PD and FCR at low costs. | PMC10441870 |
Purpose | PD, CAncer, CAREST | To evaluate the long-term effectiveness of the CAncer REcurrence Self-help Training (CAREST trial) to reduce PD and FCR. Moreover, to evaluate the relation between FCR and PD across time and identify subgroups representing different change trajectories in FCR over time and their predictors. | PMC10441870 | |
Methods | PD, Cancer | FEMALE BREAST CANCER, RECURRENCE, CANCER | This multicenter randomized controlled trial included 262 female breast cancer survivors, assigned to online self-help training or care as usual. Participants completed questionnaires at baseline and four times during the 24-month follow-up. The primary outcomes were PD and FCR (Fear of Cancer Recurrence Inventory). La... | PMC10441870 |
Results | PD | LGCM showed no differences between the average latent slope in both groups for both PD and FCR. The correlation between FCR and PD at baseline was moderate for the intervention group and strong for the CAU group and did not significantly decrease over time in both groups. RMLCA revealed five latent classes and several ... | PMC10441870 | |
Conclusions | PD, cancer recurrence and psychological distress, breast cancer | BREAST CANCER | We did not find a long-term effect of the CBT‐based online self-help training in reducing PD or FCR, nor in their relation. Therefore, we recommend adding professional support to online interventions for FCR. Information about FCR classes and predictors may contribute to improvement of FCR interventions.This study show... | PMC10441870 |
Introduction | breast) cancer, cancer, PD, breast cancer | CANCER, BREAST CANCER | Advances in the diagnosis and treatment of (breast) cancer have resulted in increased survival rates. As a result, there is an increasing group of breast cancer survivors that have to cope with the long-term consequences of cancer. Fear of cancer recurrence (FCR) is one of the most common long-term psychological conseq... | PMC10441870 |
Materials and Methods | CAREST | The CAREST trial was registered in the Dutch Trial Register (NTR4119). The Medical Ethical Committee of the Maasstad hospital (TWOR) in Rotterdam approved this trial (reference number 2013/41) and all participating hospitals provided local ethics approval. The study protocol of this trial has been published [ | PMC10441870 | |
Design | We conducted a multicenter randomized controlled trial (RCT) with two conditions. The intervention group received a CBT-based online self-help training to reduce FCR. Both the intervention group and the control group received care as usual (CAU), standard care in their own hospital.The original sample size calculation ... | PMC10441870 | ||
Participants | breast cancer | DISEASE, RECURRENCE, METASTATIC DISEASE, BREAST CANCER | Women were eligible to participate when they had a diagnosis of breast cancer 1–5 years ago, had no signs of local or regional recurrence or metastatic disease (according to their oncologist or oncology nurse), were capable of completing questionnaires in Dutch, were 18 years or older at disease onset, and had access t... | PMC10441870 |
Recruitment | Cancer | MAY, RECURRENCE, CANCER | Eligible patients were recruited consecutively during their regular checkup at the outpatient clinic of a hospital or by sending them a comprehensive information letter by mail (differed because of pragmatic reasons) between April 2014 and May 2016. Participating hospitals (all situated in the Netherlands) were the Maa... | PMC10441870 |
Randomization | Participants were randomly allocated to either the online self-help training (intervention) or CAU with an allocation ratio of 1:1, stratified by hospital. Block randomization (block size 10) was carried out through the sealed envelope system. Randomization was conducted by a researcher who was not otherwise involved i... | PMC10441870 | ||
Intervention | POSITIVE | In short, the intervention is a CBT-based online self-help to reduce FCR. The program included two generic modules containing psycho-education about FCR and the basic principles of CBT, and four optional modules: (a) Stop worrying; (b) Positive actions; (c) Relax; and (d) Reassurance [ | PMC10441870 | |
Measures | breast cancer, PD, Cancer | BREAST CANCER, RECURRENCE, CANCER | Socio-demographic and medical variables were self-reported and assessed at baseline and at all time points, respectively. The self-report questionnaires were assessed at all time points.The primary outcomes FCR and PD were both assessed with the Dutch translation of the Fear of Cancer Recurrence Inventory (FCRI-NL) [Si... | PMC10441870 |
Statistical Analyses | Prior to data analysis, we checked the normality assumptions. When the assumption of multivariate normality was not met, we executed transformations of the dependent variable. When transformation did not lead to multivariate normality, we used robust maximum likelihood estimation (MLR) to fit the model. | PMC10441870 | ||
RQ1: Long-Term Effectiveness of Online Self-Help Training in Reducing FCR and PD | PD | To answer the first research question (i.e., do the intervention and CAU group differ in the change in FCR/PD over time), a multi-group second-order latent growth model was estimated. A second-order growth model estimates individual growth curves for each participant based on the individual FCR or PD item scores. A mul... | PMC10441870 | |
RQ2: Relation Between FCR and PD Over Time | PD | Answering the second research question (i.e., does the association between FCR and PD decrease over time), we started with a multivariate multi-group growth model including both FCR and PD scores over time. However, as this multivariate second order growth model did not converge, we used a first order growth model that... | PMC10441870 | |
RQ3: Change Trajectories in FCR Over Time and Their Predictors | For the last research question (i.e., can we distinguish characteristics of patients for whom the intervention worked), we modeled a repeated measures latent class analysis (RMLCA) within the intervention group. RMLCA analyses were performed with Latent Gold (version 5.0.0) [
| PMC10441870 | ||
Results | PMC10441870 | |||
Response Rate and Sample Characteristics | CAREST | Details about enrollment, intervention allocation, follow-up, and drop-out can be found in the flowchart (CONSORT diagram for participant inclusion and retention up to 24 months in the CAREST randomized controlled trial. Women in the RCT had a mean age of 55.8 years ( | PMC10441870 | |
RQ1: Long-Term Effectiveness of Online Self-help Training in Reducing FCR and PD | PD | When testing the assumption of longitudinal measurement invariance for FCR, the multi-group univariate second order latent growth model indicated no differences between the loadings of the five longitudinal factors across time, based on the chi-square difference test comparing sub-models 0a and 1a (Latent Growth Models... | PMC10441870 | |
RQ2: Relation Between FCR and PD Over Time | PD, cancer recurrence and psychological distress | In line with the findings of the second order growth model, the results of the first order growth model indicate no significant change in FCR across time, for both the intervention (The results of these chi-square difference tests were confirmed by the model fit indices. Both AIC and BIC suggest a slightly better fit t... | PMC10441870 | |
RQ3: Change Trajectories in FCR Over Time and Their Predictors | Cancer | RECURRENCE, POSITIVE, CANCER | First, we identified the optimal number of latent classes, where each class represents a distinct change pattern of FCRI for participants in the intervention group. BIC showed that a model with three different classes fitted the data best, while AIC and AIC3 suggested a model with five different classes. Because of the... | PMC10441870 |
Sensitivity Analyses | More than one-third (37%) of the intervention group reported they did not actually follow the online self-help training, although they had access to the intervention. However, participants who followed the online self-help intervention and participants who did not follow the intervention did not differ from one another... | PMC10441870 | ||
Discussion | PD, cancer, anxiety | CANCER | The current study is one of the few studies that investigate the effect of an online self-help training for FCR with a follow-up of 24 months. Results indicate no change of both FCR and PD across time, for both the intervention and CAU group, nor any effect of the intervention on the relation between FCR and PD, nor di... | PMC10441870 |
Limitations and Strengths | PD, Depression, Anxiety | SENSITIVITY | This study had several limitations. First, since R package Lavaan gave a warning for all growth models using both MLR estimation and other robust estimators, ML estimation was used to fit the model. Presumably, the model with several hundred parameters was too large for our data. The ML estimator is not robust against ... | PMC10441870 |
Clinical Implications | PD, breast cancer | BREAST CANCER | Levels of FCR and PD seem to be stable over time (showed no significant natural decrease), which underlines the importance to develop interventions for both FCR and PD in breast cancer survivors. In the current study, we found no (long-term) effect of our online self-help training. To retain the benefits of online inte... | PMC10441870 |
Conclusions | cancer, PD | CANCER | In conclusion, five latent classes and several predictors of class membership were found. Knowing more about the specific needs of FCR groups, may contribute to the improvement of interventions for FCR.Furthermore, there was no (long-term) effect of the CBT‐based online self-help training “Less fear after cancer” in re... | PMC10441870 |
Supplementary Material | Click here for additional data file. | PMC10441870 | ||
Acknowledgements | der | DER | This research is funded by a grant from Pink Ribbon, the Netherlands (2012.WO43.C158), awarded to Dr. M.L. van der Lee. We are grateful to the patients for their participation in this trial and to oncology nurses, nurse practitioners, and oncologists from the Maasstad hospital in Rotterdam, St. Antonius hospital in Utr... | PMC10441870 |
Funding | DER | This study was funded by Pink Ribbon (2012.WO43.C158) awarded to Dr Marije L. van der Lee. Pink Ribbon was not involved in the collection, analysis, and interpretation of data, in writing manuscripts or deciding to submit manuscripts for publication. | PMC10441870 | |
Compliance with Ethical Standards | PMC10441870 | |||
References | PMC10441870 | |||
Methods | malaria, malaria infection | MALARIA, REGRESSION, SECONDARY | The trial was a community randomized control in which there were two malaria prevalence cross-sectional household surveys each year (June and December) from 2015 to 2017 in Muleba. In this study we conducted a secondary data analysis of the December surveys only. Multilevel Poisson regression analysis was used to asses... | PMC10734997 |
Results | malaria, malaria infection | MALARIA | A total of 10,941 children and 4,611 households were included in this study. Overall malaria prevalence was 35.8%, 53.3% and 54.4% in the year 2015, 2016 and 2017 respectively. Living in an area with standard LLIN as opposed to the novel PBO synergist LLIN, being a male child, above 5 years of age, living in a house wi... | PMC10734997 |
Conclusions | malaria infection | Using PBO LLIN reduced the risk of malaria infection. However, additional measures could further reduce malaria infection in areas of insecticide resistance such as housing improvement. | PMC10734997 | |
Data Availability | Data in Tanzania are governed by strict law and cannot be shared outside the country without a Data Transfer agreement (DTA.pdf (nimr.or.tz)) and appropriate ethical approval. There was no provision under this study to share the data widely outside and was not mentioned in the consent form. A DTA process will need to b... | PMC10734997 | ||
Background | malaria | MALARIA, WEST, DISEASE | After a decade of successful control, malaria is on the rise again in Sub- Saharan Africa [In Tanzania, malaria accounts for 30% to 40% of all disease burden and 7% of all mortality [LLIN has been a core component of the Tanzanian malaria control strategy since 2009 [In 2008, Kagera region in North West Tanzania had th... | PMC10734997 |
Materials and methods | PMC10734997 | |||
Data source | malaria, malaria infection | MALARIA, MALARIA | The trial was a four arms, single-blinded, cluster randomized factorial design conducted in Muleba district in the northwestern part of Tanzania from 2015 to 2017. This trial is registered with ClinicalTrials.gov, number NCT02288637. The detail of the parent study procedures have been described elsewhere [Standard LLNs... | PMC10734997 |
Description of the sub- study | The cross-sectional data from December surveys was used for risks factors analysis over the three year’ life span of the LLINs. The type of LLIN was considered as the primary exposure therefore the arms receiving the same type of LLIN (Standard LLIN or PBO LLIN) were combined to form two arms regardless of IRS. Sample ... | PMC10734997 | ||
Data management and statistical analysis | Data were extracted from the parent study database which was in Microsoft Access (Microsoft Corporation, Redmond, USA) format and transferred into STATA version13 (Stata-Corp, College Station, TX, USA) for further cleaning and statistical analysis. A description of all the independent variables included in the study is... | PMC10734997 | ||
Description of the study variables. | malaria, malaria infection | MALARIA, REGRESSION, INTERACTIONS, INTERACTION | For categorical variables, numbers and proportions (percentages) in each level were calculated. For continuous variable median and inter-quartile range (IQR) were calculated.Given that malaria prevalence was more than 40% in the study area; Poisson regression was used as an alternative to logistic regression to determi... | PMC10734997 |
Ethics statement | SECONDARY | The main trial was approved by the ethics review committees of the Kilimanjaro Christian Medical University College, the London School of Hygiene & Tropical Medicine, and the Tanzanian Medical Research Coordinating Committee (NIMR/HQ/R.8a/VolIX/1803). Written informed consent from parents or guardians was obtained for ... | PMC10734997 | |
Results | PMC10734997 | |||
Participants and household characteristics | malaria, malaria infection | MALARIA | A total of 48 clusters were surveyed at each time point. For the three surveys, data were available for 5,221 households with children aged 6 months to 14 years and 11,275 children were tested for malaria. About 11% of selected children in each survey year were not tested for malaria infection. After data cleaning and ... | PMC10734997 |
Flow chart of selected households and children included in the study, Muleba Tanzania. | A total of 10,941 children with a median age of 7 (IQR: 4, 10) years were analysed. There were an almost equal number of children between study arms across all surveys. LLIN usage dropped over survey time. However, the proportion was almost balanced between arms, except during the second year of the trial in 2016, 1221... | PMC10734997 | ||
Household and individual characteristics of study participants by study arm for 2015–2017 surveys, Muleba Tanzania. | *Two households (0.3%) missing. | PMC10734997 | ||
Malaria prevalence and factors associated with malaria infection | malaria | MALARIA | The malaria prevalence increased over the years from 35.8% in 2015 to 54.4% in 2017. Overall malaria prevalence was 41.6% in the PBO LLIN arm and 51.6% among children living in the standard LLIN arm ( | PMC10734997 |
Univariate multilevel Poisson regression of factors associated with malaria infection among children in Muleba, Tanzania. | malaria, malaria infection | REGRESSION, MALARIA | In the univariate multilevel Poisson regression analysis, all factors except for the household IRS status had a statistically significant association with malaria infection among the selected children (In the multivariable multilevel analysis, about 5% (ICC = 0.05) of the total variability in the risk of malaria infect... | PMC10734997 |
Multivariable multilevel Poisson regression analysis of factors associated with malaria infection among children in Muleba, Tanzania(N = 10,880). | infection, malaria infection | MALARIA, INFECTION, SECONDARY | *Risk ratio adjusted for all variables in the table.The age of the child was highly associated with malaria infection, children aged 5 to 10 years and above 10 years had 27% and 26% higher risk respectively compared to those less than 5 years of age with (aRR = 1.27; 95%CI: 1.18, 1.36) and (aRR = 1.26; 95%CI: 1.18, 1.3... | PMC10734997 |
Discussion | malaria, infection, malaria infection | MALARIA, INFECTION | The results show an overall increase in malaria prevalence in the study area over the years. Prevalence was higher amongst children living in areas with standard LLINs as opposed to those living in villages with PBO LLINs. Other factors associated with malaria infection were being a male and greater than 5 years old. C... | PMC10734997 |
Conclusions | malaria infection | The present analysis suggests that using of PBO LLINs reduced the risk of malaria infection in this area of high pyrethroid resistance compared to Standard LLIN. However, the overall prevalence still remains high and increased during the 3 years of the trial. This suggest increasing coverage of the PBO LLINs as well as... | PMC10734997 | |
Supporting information | PMC10734997 | |||
STROBE statement—checklist of items that should be included in reports of observational studies. | MALARIA | (DOC)Click here for additional data file.Would like to convey our gratitude to Ifakara Health Institute-IHI, Tanzania under clinical trial unit and DELTAS Sub-Saharan Africa Consortium for Advanced Biostatistics (SSACAB) Training Programme for financial support during the MSc. Training. Authors would like to acknowledg... | PMC10734997 | |
References | PMC10734997 | |||
Background | postoperative pain, musculoskeletal injuries | Postoperative intravenous diclofenac reduces patient opioid demand and is commonly used in surgical units. Orphenadrine is mainly used in combination with diclofenac for musculoskeletal injuries and postoperative pain control. The objective of this study was to compare the analgesic efficacy of diclofenac-orphenadrine,... | PMC9938044 | |
Methods | delirium | We performed a double-blind, randomized, placebo-controlled, parallel-group, single-center clinical study investigating the opioid-sparing effect of a combination of diclofenac and orphenadrine versus diclofenac alone versus isotonic saline solution. Initially 72 patients were included and received total intravenous an... | PMC9938044 | |
Results | ± | There was no significant difference between the groups in cumulative dose of PCA analgesics required after 24 h postsurgery, with 5.90 mg (SD ± 2.90 mg) in the placebo group, 5.73 mg (SD ± 4.75 mg) in the diclofenac group, and 4.13 mg (SD ± 2.57 mg) in the diclofenac-orphenadrine group. Furthermore, there was no signif... | PMC9938044 | |
Conclusion | postoperative pain | Orphenadrine-diclofenac failed to significantly reduce postoperative opioid requirements. However, in an exploratory post hoc analysis the diclofenac-orphenadrine and the diclofenac group combined versus placebo showed a tendency to reduce opioid demand in postoperative pain control. Further research is required to det... | PMC9938044 | |
Keywords | Open access funding provided by Medical University of Vienna. | PMC9938044 | ||
Introduction | Parkinson’s disease, hyperalgesia, pain | SECONDARY | The benefits of effective pain management after surgery and the favorable effect on fast recovery and outcome are well documented [Orphenadrine is a centrally acting muscle relaxant initially used for the treatment of Parkinson’s disease. In addition, it has anticholinergic and antihistaminic properties and a potential... | PMC9938044 |
Methods | PMC9938044 | |||
Study design | The study was performed at the Vienna General Hospital, which is also the site of the Medical University of Vienna and provides more than 50,000 surgeries per year. The study was conducted as a double-blind, randomized, placebo-controlled, parallel-grouped, single-center clinical study. | PMC9938044 | ||
Ethics | This study was conducted in accordance with the declaration of Helsinki and the good clinical practice guidelines. The study protocol as well as the written consent form were approved (EK 1494/2016) by the Ethics Committee of the Medical University of Vienna (Chairperson: Univ.-Doz. Dr. Martin Brunner; Borschkegasse 8b... | PMC9938044 | ||
Study population | Included were patients undergoing elective cruciate ligament surgery. Every patient received a standard of care total intravenous anesthesia consisting of an induction with propofol, remifentanil and, if relaxation required, rocuronium followed by a maintenance with remifentanil (0.15–0.25 μg⋅kgSample size calculations... | PMC9938044 | ||
Study intervention | Patients were randomly allocated in a 1:1:1 ratio to 1 of 3 study arms and received either 2×250 ml solutions of 75 mg diclofenac combined with 30 mg of orphenadrine, 2×250 ml solutions of 75 mg diclofenac or 2×250 ml solutions of isotonic saline in a double-blind setting. Randomization of the study patients in a 1:1:1... | PMC9938044 | ||
Statistics | delirium, pain | SECONDARY | The primary outcome of the study was the total dose of PCA analgesics required 24 h after surgery. The secondary outcomes were PCA analgesics required 2 h after surgery, pain intensity measured by visual analogue scales (VAS) 2 h and 24 h after surgery.Exploratory outcomes: furthermore, the local and systemic tolerabil... | PMC9938044 |
Discussion | postoperative pain, bleeding, hyperalgesia, low pain, allodynia, pain, renal dysfunction | THROMBOPHLEBITIS, EVENTS, BLEEDING, PCP | In the present study, there was no significant difference for the postoperative opioid PCA requirements between the diclofenac-orphenadrin, the diclofenac and the placebo group for the treatment of postoperative pain in patients receiving cruciate ligament surgery. However, a distinct trend towards a reduction of hydro... | PMC9938044 |
Acknowledgements | We want to thank Dr. Martina Hermann, Dr. Stefan Koch and Dr. Udo Eggenreich for their help with carrying out the study. | PMC9938044 | ||
Funding | This study was partially funded by Fresenius Kabi Austria GmbH (Graz, Austria). | PMC9938044 | ||
Author Contribution | S. Zeiner: conceptualization, formal analysis, methodology, project administration, validation, writing—original draft, visualization, data curation; T. Haider, O. Zotti, P. Höbart, E. Knolle: conceptualization, data curation, resources, writing—review & editing; O. Kimberger.: conceptualization, formal analysis, metho... | PMC9938044 | ||
Funding | Open access funding provided by Medical University of Vienna. | PMC9938044 | ||
Conflict of interest | Thomas | Professor Kimberger was a member of the advisory board of ZOLL Medical Österreich GmbH (Vienna, Austria) until 2019. Thomas Haider, Petra Höbart, Oliver Zotti, Katrin Thüringer, Erich Knolle and Sebastian Zeiner declare that they have no conflicts of interest. | PMC9938044 | |
References | PMC9938044 | |||
1. Introduction | sore throat, nausea, myalgia, fatigue, fever, pain, cough, dizziness, skin rash, sleep problems, depressive, loss of taste and smell, headache, coronavirus disease 2019, Fatigue | SORE THROAT, VIRUS, CORONAVIRUS DISEASE 2019, VIRAL DISEASES, RESPIRATORY TRACT INFECTIONS, SYNDROME, CORONAVIRUS | The aim of this study was to compare the effectiveness of traditional neurological rehabilitation and neurological rehabilitation combined with a rehabilitation robot for patients with post-COVID-19 fatigue syndrome. Eighty-six participants transferred from intensive care units due to post-viral fatigue after COVID-19 ... | PMC10575211 |
2. Materials and Methods | muscle contraction, fatigue | MUSCLE WEAKNESS, CONTRACTION, POLAND | A prospective randomized clinical trial was conducted in the Neuro-rehabilitation Ward of the Provincial Hospital in Poznan, Poland, between January and August 2022. The study has been registered with ClinicalTrials.gov, ID: NCT05130736.Participants who were transferred directly from Intensive Care Units (ICUs) due to ... | PMC10575211 |
2.1. Measurement | hand dynamometer | Several measurement tools were used to assess functional physical ability (Berg scale, Tinetti scale, six-minute walking test (6MWT)), muscle strength (isokinetic muscle force of elbow flexors and extensors, hand grip strength (GS)), and independence in activities of daily living (Barthel Index, Functional Independence... | PMC10575211 | |
2.2. Statistical Analysis | POLAND | Statistical analysis was performed with Statistica 13.3 software (TIBCO Software/StatSoft Polska Sp. z o.o., Krakow, Poland). The threshold for statistical significance was set at | PMC10575211 | |
3. Results | A total of 86 participants were included in the study. However, due to various causes, five participants did not complete the study. Therefore, data from 81 participants (42 in IG and 39 in CG) were analyzed. There were significant differences between groups in terms of weight and BMI, yet groups did not differ in age,... | PMC10575211 | ||
4. Discussion | stroke, fatigue, Kawasaki | STROKE, SYNDROME, KAWASAKI | The use of robots in rehabilitation gained significant traction in 1990 [Villafañe et al. [Some other authors found that robot-assisted rehabilitation can be more efficient than traditional rehabilitation. Dehem et al. [As stated previously, the majority of available studies using robots in rehabilitation were conducte... | PMC10575211 |
5. Conclusions | fatigue | SYNDROME | In light of the results of the present study, implementing EMG-driven robots in the rehabilitation of post-COVID-19 fatigue syndrome patients is effective. Substituting a part of traditional rehabilitation with robotic rehabilitation did not negatively alter rehabilitation outcomes. Our results indicate that the implem... | PMC10575211 |
Author Contributions | Conceptualization, E.Z., D.K., S.T. and K.H.; formal analysis, T.T. and A.P. (Anna Pieczyńska); investigation, R.M.; methodology, T.T., D.K. and I.Z.; project administration, R.M. and E.Z.; resources, K.H., M.M. and A.P. (Anna Poświata); supervision, K.H.; writing—original draft, T.T.; writing—review and editing, T.T.,... | PMC10575211 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Bioethics Committee of Poznan University of Medical Sciences (Protocol No. 514/21). | PMC10575211 |
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