title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Consent for publication | Not applicable. | PMC10338470 | ||
References | PMC10338470 | |||
Abstract | PMC10435932 | |||
Introduction | cough | BRONCHIECTASIS, SIDE EFFECT, ADVERSE EVENTS, BRONCHIAL HYPERREACTIVITY, BRONCHOSPASM | Tobramycin inhalation solution (TIS) is a treatment option for patients with frequent exacerbations of bronchiectasis. A possible side effect of TIS is the development of chronic cough and bronchospasm, whereby the guidelines suggest a (in hospital) tolerance test with the first dose of TIS. However, data on respirator... | PMC10435932 |
Methods | Fifty‐seven | ADVERSE EVENT | Fifty‐seven patients from the BATTLE study were analyzed. Patients were randomized to receive TIS or placebo OD for 1 year. A tolerance test was performed with spirometry measurements before and after the first dose and with a bronchodilator in advance. Adverse events were strictly monitored. | PMC10435932 |
Results | Fifty‐seven, airway hyperresponsiveness | AIRWAY HYPERRESPONSIVENESS | Fifty‐seven patients (100%) passed the tolerance test with no decrease in spirometry measurements or development of local intolerability. During the study treatment, a total of five TIS‐treated patients (17.8%) withdrew due to airway hyperresponsiveness after a mean of 9.2 (SD13.9) weeks and one placebo‐treated patient... | PMC10435932 |
Conclusion | heterogenous bronchiectasis, airway hyperresponsiveness | AIRWAY HYPERRESPONSIVENESS, ADVERSE EFFECTS | The use of inhaled medication is well tolerated in the heterogenous bronchiectasis population, without signs of airway hyperresponsiveness after the first dose of inhaled medication. From this observation, it can be concluded that there is no additional value for this advised tolerance test. However, closely monitoring... | PMC10435932 |
INTRODUCTION | CHRONIC INFLAMMATION, BRONCHIECTASIS | Bronchiectasis is characterized by the presence of dilated bronchi and chronic inflammation, which leads to persistent coughing and sputum production with recurrent exacerbations. | PMC10435932 | |
METHODS | PMC10435932 | |||
Study population | In the present analysis, data from the BATTLE RCT were included. | PMC10435932 | ||
Objectives | bronchiectasis, airway hyperresponsiveness | ADVERSE EVENTS, AIRWAY HYPERRESPONSIVENESS, BRONCHIECTASIS | The primary objective of this study is to evaluate the presence of airway hyperresponsiveness during the tolerance test in patients treated with TIS as compared with placebo. Secondary objectives were time to first signs of airway hyperresponsiveness for patients treated with TIS as compared with placebo, number of tre... | PMC10435932 |
Tolerance test | Patients were clinically stable at the start of the study, and a tolerance test with the first dose of the study medication was performed for each patient at the outpatient ward. Patients were excluded if they failed the tolerance test. Study visits were planned every 3 months for 1 year, and a diary card was used ever... | PMC10435932 | ||
Statistical analysis | Statistical analysis was conducted using IBM SPSS 25 for Windows. Discrete variables were presented as counts (percentage) and continuous variables as mean with ±standard deviation (SD) if normally distributed or median with interquartile range (IQR) if not normally distributed. Comparison between groups was performed ... | PMC10435932 | ||
RESULTS | PMC10435932 | |||
Patients | Fifty‐seven | Fifty‐seven patients out of 58 who participated in the BATTLE studyPatient characteristics.
Abbreviations: AZM, azithromycin; ICS, inhalation corticosteroids; IQR, interquartile range; LABA, long acting β agonist; LAMA, long‐acting anticholinergics; SABA, short acting β agonist; SAMA, short acting anticholinergics; SD,... | PMC10435932 | |
Tolerance test | airway obstruction, SD | AIRWAY OBSTRUCTION | The tolerance test was performed in 57 patients, whereof 2 (3.5%) patients did not receive salbutamol dose aerosol in advance. All patients passed the tolerance test without severe airway obstruction (defined as a decrease in FEVTolerance test.
Abbreviations: FEV1, forced expiratory volume in one second; FVC, forced vi... | PMC10435932 |
Reasons for study discontinuation | renal impairment, bronchiectasis, allergic reaction, swelling, idiopathic bronchiectasis, tinnitus, ototoxicity, COPD | RENAL IMPAIRMENT, BRONCHIECTASIS, ALLERGIC REACTION, ADVERSE EVENTS, TINNITUS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, COPD, IDIOPATHIC BRONCHIECTASIS, ASTHMA, OTOTOXICITY | During the study treatment, a total of 18 (31.6%) patients withdrew from the study: 11 (19.3%) TIS‐treated patients after a mean of 10 weeks (SD 10.6) and 7 (12%) placebo‐treated patients after a mean of 7.7 (SD 6.4) weeks (Overview of reasons for study discontinuation.
Abbreviations: ns, non‐significant; SD, standard ... | PMC10435932 |
DISCUSSION | renal impairment, bronchiectasis, dyspnea, heterogenous bronchiectasis, cough, airway hyperresponsiveness | RENAL IMPAIRMENT, BRONCHIECTASIS, ADVERSE EVENTS, AIRWAY OBSTRUCTION, AIRWAY HYPERRESPONSIVENESS, ADVERSE EFFECTS | The present sub‐analysis of the BATTLE studyA total of 57 patients underwent a tolerance test with the first dose of the inhaled medication (TIS or placebo) with salbutamol DA in advance. None of these patients showed a lung function decline or other signs of airway hyperresponsiveness after the tolerance test. Despite... | PMC10435932 |
AUTHOR CONTRIBUTIONS | W. G. Boersma and Lotte C. Terpstra designed and drafted the manuscript. All authors were involved in revising the manuscript and have given final approval of the version to be published. | PMC10435932 | ||
CONFLICT OF INTEREST STATEMENT | WGB reported grants paid to his institution from GlaxoSmithKline and reported consulting fee for the Adviesraad 2021. IB and HH reported grants form Longfonds and CF fonds paid to their institution. LCT and DG have nothing to disclose. | PMC10435932 | ||
ETHICS STATEMENT | This study is a sub analysis of the BATTLE study. The BATTLE study protocol was reviewed and approved by independent ethics committees and institutional review boards from all the six participating centres. The study was performed in accordance with the Good Clinical Practice guidelines, the International Conference on... | PMC10435932 | ||
Supporting information |
Click here for additional data file. | PMC10435932 | ||
ACKNOWLEDGEMENTS | Not applicable. | PMC10435932 | ||
DATA AVAILABILITY STATEMENT | The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. | PMC10435932 | ||
REFERENCES | PMC10435932 | |||
1. Introduction | obesity, depression, anxiety, diabetes | OBESITY, PREGNANCY-INDUCED HYPERTENSION, SECONDARY, COMPLICATIONS, DIABETES | Mental health problems and obesity are two common complications during pregnancy and postpartum. The preconception period is considered an appropriate period for prevention. Therefore, insights into interpregnancy mental health and the impact on weight and body composition are of interest to developing effective weight... | PMC10384439 |
2. Materials and Methods | weight gain, eating behavior, weight retention, gestational diabetes | PREGNANCY-INDUCED HYPERTENSION, GESTATIONAL DIABETES, COMPLICATIONS | The interpregnancy coaching for a healthy future (INTER-ACT) (ClinicalTrials.gov; NCT02989142) intervention is a combined e-health-supported and face-to-face coaching program, from childbirth to the end of the next pregnancy, in women with excessive gestational weight gain in the previous pregnancy. The primary aim of ... | PMC10384439 |
2.1. Study Design | The INTER-ACT RCT was a multicenter RCT with a longitudinal study design. Participants received the first study visit 6 weeks after childbirth. The intervention group received the next study visit on week 12 and months 6, 12, 18, 24 and 30 after childbirth and the control group at months 6, 12, 18, 24 and 30. Once part... | PMC10384439 | ||
2.2. Participants | MAY | Participants were enrolled in 6 Flemish hospitals between May 2017 and April 2019. Women were informed and recruited by trained study nurses 2 to 3 days after childbirth if they had excessive GWG according to the 2009 National Academy of Medicine (NAM) guideline [A total of 1450 women were enrolled and registered in th... | PMC10384439 | |
2.3. Measurements | Anxiety, anxiety, depressive symptoms, depression, Depression | All participants were assessed at 6 weeks after childbirth and at the start of the next pregnancy by completing self-reported questionnaires. A personal link to the questionnaire was sent from the eCRF two weeks before the scheduled study visit.Mental health was assessed by using the Edinburgh Postnatal Depression Scal... | PMC10384439 | |
2.4. Outcomes | Study nurses collected the self-reported pre-pregnancy weight before the previous pregnancy from the medical records 2 to 3 days after childbirth, and the self-reported pre-pregnancy weight of the next pregnancy was questioned by the INTER-ACT coach at the first INTER-ACT pregnancy visit. Body composition was electroni... | PMC10384439 | ||
2.5. Data Analyses | USA).The, depression, weight retention, anxiety | REGRESSION | Statistical analyses were performed by using Statistical Package for the Social Science (SPSS) version 27.0 (IBM, Armonk, New York, NY, USA) and Statistical Analysis System (SAS) version 9.4 (Cary, New York, NY, USA).The Kolmogorov–Smirnov test in addition to plots and histograms was used to assess the normality of dis... | PMC10384439 |
3. Results | PMC10384439 | |||
3.1. Participant Characteristics | Of the 1450 women randomized in the INTER-ACT trial, 276 women had a next pregnancy and complete data (At baseline (6 weeks after childbirth), a difference in QoL was found between the intervention and control group (median score; 80 versus 81, | PMC10384439 | ||
3.2. Differences in Mental Health between 6 Weeks after Childbirth and Start of Next Pregnancy | anxiety, depressive symptoms | The rate of women with symptoms of anxiety (sSTAI-6 ≥ 40) increased by 13% between 6 weeks after childbirth and the start of the next pregnancy (36% vs. 49%, Also, the rate of women who reported depressive symptoms at the start of the next pregnancy doubled compared to 6 weeks after childbirth (GMDS ≥ 13; 17% versus 8%... | PMC10384439 | |
3.3. Mental-Health-Related Characteristics | PMC10384439 | |||
3.3.1. Socio-Demographic Factors and Interpregnancy Interval | obesity, depressive feelings, anxiety, depressive symptoms | OBESITY | Women with a history of depressive feelings or a history of anxiety feelings reported more often depressive symptoms (EPDS ≥ 10, GMDS ≥ 13), anxiety (sSTAI-6 ≥ 40, EDS-3A ≥ 5) or a low SOC (SOC-13 ≤ 70) at the start of the next pregnancy. Also, women with obesity before the start of the previous pregnancy reported more... | PMC10384439 |
3.3.2. Sleep | Women with less than 6 h of sleep per night at the start of the next pregnancy more often reported a low SOC (SOC < 70; 5 h or less = 54%; 5–6 h = 59%) compared to women with more than 6 h of sleep per night (SOC < 70; 6–7 h = 35% and more than 7 h = 45%) ( | PMC10384439 | ||
3.4. Association with Pre-Pregnancy BMI and Body Composition | REGRESSION | Regression analyses showed that when taking into account pre-pregnancy BMI of the previous pregnancy, level of education and breastfeeding, only sense of coherence at the start of the next pregnancy was independently associated with women’s BMI and fat percentage at the start of the next pregnancy and BMI change betwee... | PMC10384439 | |
4. Discussion | depression, overweight or obesity, anxiety, depressive symptoms | We showed a significant increase in anxiety (+13%, In contrast to the STAI-6 (symptoms of anxiety), sense of coherence is a personality trait that indicates the ability to understand, manage and give meaning to situations. It increases resistance to stress and promotes the person’s development [We also found that sympt... | PMC10384439 | |
5. Conclusions | depressive, anxiety, weight reduction | STRESSFUL EVENTS | Our data show a significant increase in anxiety and depressive symptoms between the start and the end of the interpregnancy period. Of the women who were not anxious at the start, 39% experienced anxiety at the end of interpregnancy. Sense of coherence at the start of the next pregnancy was independently associated wit... | PMC10384439 |
Supplementary Materials | The following supporting information can be downloaded at: Click here for additional data file. | PMC10384439 | ||
Author Contributions | Conceptualization, H.V.U., A.B., L.A. and R.D.; methodology, H.V.U., A.B., L.A. and R.D.; software, L.A.; validation, H.V.U., A.B., L.A. and R.D.; formal analysis, H.V.U. and L.A.; investigation, H.V.U. and L.A.; resources, A.B. and R.D.; data curation, L.A.; writing—original draft preparation, H.V.U.; writing—review a... | PMC10384439 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved on 9 March 2017 by the Institutional Review Board (or Ethics Committee) of UZ Leuven (protocol code B322201730956/S59889). | PMC10384439 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10384439 | ||
Data Availability Statement | The study protocol is publicly available. Data requests may be submitted to the Principal Investigator accompanied by a proposal with a planned objective for use of data. | PMC10384439 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC10384439 | ||
References | Depression, Anxiety, anxiety, depressive symptoms | REGRESSION, SECONDARY | Flow chart of participant follow-up.Differences in sSTAI-6 and GMDS during the interpregnancy period. sSTAI-6 N = 276; GMDS N = 131; Symptoms of anxiety = sSTAI-6 ≥ 40; depressive symptoms = GMDS ≥ 13; and GMDS was recoded from 3 to 2 categories (<13 and ≥13) because of only 1 case in category 3. group 1 = No symptoms ... | PMC10384439 |
Purpose | Communicated by Westerterp/Westerblad.The acute physiological, perceptual and neuromuscular responses to volume-matched running and cycling high intensity interval training (HIIT) were studied in team sport athletes. | PMC9813096 | ||
Methods | In a randomized cross-over design, 11 male team sport players completed 3 × 6 min (with 5 min between sets) repeated efforts of 15 s exercising at 120% speed (s | PMC9813096 | ||
Results | Absolute mean | PMC9813096 | ||
Conclusion | Cycling HIIT in team sport athletes is unlikely to meet the requirements for improving run-specific metabolic adaptation but might offer a greater lower limb neuromuscular load. | PMC9813096 | ||
Keywords | PMC9813096 | |||
Introduction | As an appropriate stimulus for improving In many team sports, practitioners and rehabilitation staff will choose training practices that simultaneously reduce musculoskeletal load while promoting appropriate central and peripheral stimuli. The use of cycle-based HIIT has been used with team sport athletes over periods ... | PMC9813096 | ||
Methods | stature | With Department of Sport and Exercise Sciences ethics approval, 11 male university standard team sport players (age 20.0 ± 0.8 y, stature 181 ± 5 cm, body mass 82.3 ± 12.4 kg) participated in this study after providing written informed consent. Participants represented a range of team sports, including soccer, rugby an... | PMC9813096 | |
Statistical analysis | All comparisons are reported as effect sizes (Cohen’s d; mean difference between trials/pooled standard deviation) and 95% confidence intervals (ES [95% CI]), with threshold values of 0.0–0.2, trivial; 0.21–0.6, small; 0.61–1.2, moderate; 1.21–2.0, large; > 2.0, very large. These arbitrary thresholds were used in the a... | PMC9813096 | ||
Results | breathlessness | sPhysiological responses to maximal running and cycling tests. Data are mean ± SD*denotes different to cycling value (Physiological responses to running and cycling HIIT sessions are shown in Table Physiological responses to running and cycling HIIT sessions*denotes different to cycling value (Time spent > 90%There wer... | PMC9813096 | |
Discussion | breathlessness, fatigue | Running elicited a higher Given the greater capacity and requirement for oxygen consumption during running, absolute mean Time spent at > 90% While understanding the The higher reported breathlessness (dRPE-B) for running probably reflected the higher metabolic demand and central responses (e.g., oxygen uptake, breathi... | PMC9813096 | |
Conclusion | This study examines the responses to a specific HIIT training session using cycle ergometry and running in team sport athletes, offering valuable insight to those team sport practitioners using cycle-based training with their athletes. These data highlight cycling elicited lower responses compared to running during sho... | PMC9813096 | ||
Author contributions | CT and JH conceived and designed research. RB, CT and JH conducted experiments. CT and JH analyzed data. CT wrote the manuscript. All authors read and approved the manuscript. | PMC9813096 | ||
Funding | This project did not receive any funding. | PMC9813096 | ||
Declaration | PMC9813096 | |||
Conflict of Interest | The authors declare that they have no conflict of interest. | PMC9813096 | ||
References | PMC9813096 | |||
Abstract | Presented to the ASCO Virtual Annual Meeting, June 2021 (Abstract ID 3598). | PMC10338899 | ||
Background | Evidence is lacking regarding the earliest timing of initiating adjuvant chemotherapy to maximize its efficacy safely. A trial was designed and conducted to evaluate the safety and oncological efficacy of early adjuvant chemotherapy compared with conventional adjuvant chemotherapy. The short-term outcomes are reported ... | PMC10338899 | ||
Methods | Toxicity | STAGE II COLON CANCER | A multicentre, randomized (1 : 1), open-label, phase III trial was conducted comparing early adjuvant chemotherapy with conventional adjuvant chemotherapy in patients with stage III colon cancer. Patients who underwent radical surgery who had stage III colon cancer confirmed by histopathological assessment were screene... | PMC10338899 |
Results | toxicity | Between 9 September 2011 and 6 March 2020, 443 patients consented to randomization at eight sites. The intention-to-treat population included 423 patients (209 in the early adjuvant chemotherapy arm and 214 in the conventional adjuvant chemotherapy arm), and the safety population included 380 patients (192 in the early... | PMC10338899 | |
Conclusion | toxicity | SURGICAL COMPLICATIONS, STAGE II COLON CANCER | Adjuvant chemotherapy can be safely initiated 2 weeks after surgery with toxicity and quality of life comparable to conventional adjuvant chemotherapy for stage III colon cancer.The aim of this study was to evaluate the safety of early initiation of adjuvant chemotherapy within 2 weeks after surgery in patients with st... | PMC10338899 |
Introduction | tumour, colon cancer | TUMOUR, COLON CANCER | Adjuvant chemotherapy (AC) after radical surgery is the current standard treatment for high-risk stage II and III colon cancer with a survival benefit due to eradication of micrometastasesMany preclinical studies suggest that surgery due to manipulation of the tumour may affect tumour kinetics, facilitate circulation o... | PMC10338899 |
Methods | PMC10338899 | |||
Study design and participants | AJCC Cancer, tumours, malignancy, colorectal surgeons, non-cancer-related disease, perforation, tumour obstruction, hypersensitivity, unresectable disease | ADENOCARCINOMA OF THE COLON, TUMOURS, POSTOPERATIVE COMPLICATIONS, COLON CANCER, CANCER; METASTATIC, ONCOLOGY, STAGE II COLON CANCER, HYPERSENSITIVITY | A multicentre, randomized (1 : 1), open-label, phase III trial was conducted comparing EAC with CAC in patients with stage III colon cancer. Patients were recruited from eight centres in South Korea. All centres were tertiary medical institutes with sub-specialist colorectal surgeons. Patients with stage III colon canc... | PMC10338899 |
Randomization and procedure protocol | stomatitis, malignancy, death, Cancer | ADVERSE EVENT, RECURRENCE, STOMATITIS, ADVERSE EVENTS, ADVERSE EVENT, DISEASE, EVENT, CANCER | The anaesthetic evaluation and patient information regarding the operative procedure were performed according to the local practices of each investigation centre. Radical surgery was performed as per the oncological quality criteria for resection. Preoperative and postoperative data were reported on specific forms. If ... | PMC10338899 |
Endpoints | death, Cancer | RECURRENCE, ADVERSE EVENTS, SECONDARY, SURGICAL COMPLICATIONS, CANCER | The primary endpoint was 3-year DFS, defined as the time from the date of the operation to the earliest date of recurrence.The secondary endpoint was OS, defined as the time from the date of the operation to the date of death due to all causes or the date of the last follow-up, chemotherapy-related adverse events accor... | PMC10338899 |
Statistics | The expected 3-year DFS with CAC was 72 per cent based on a literature reviewAll randomized patients were defined as the intention-to-treat (ITT) population. Patients with protocol violations, which meant the date of initiating chemotherapy did not meet the protocol, were excluded from the per-protocol population. Safe... | PMC10338899 | ||
Results | PMC10338899 | |||
Patient and disease characteristics | LATE SURGICAL COMPLICATION | Between 9 September 2011 and 6 March 6 2020, 443 patients consented to randomization at eight sites; 221 and 222 patients were allocated to the EAC arm and the CAC arm respectively (Flow diagram of study populationEAC, early adjuvant chemotherapy; CAC, conventional adjuvant chemotherapy.A total of 43 patients (17 in th... | PMC10338899 | |
Results of adjuvant chemotherapy and toxicity | toxicity, anastomotic stricture | SURGICAL COMPLICATIONS, RECURRENCE, LEAKAGE | The median times from operation to initiating AC were 13 (range 4–43) days in the EAC arm and 29 (range 17–53) days in the CAC arm (safety population) (Results of adjuvant chemotherapyValues are The median number of administered cycles and completeness of chemotherapy, including the rate of completion without dose redu... | PMC10338899 |
Quality of life | The QoL data are shown in Comparison of quality of life between the early adjuvant chemotherapy arm and the conventional adjuvant chemotherapy arm
| PMC10338899 | ||
Discussion | colorectal cancer, patientsAnastomotic leakage, toxicities, colorectal surgeons, colon cancer, colorectal resection | COLORECTAL CANCER, GASTROINTESTINAL CANCERS, RECURRENCE, POSTOPERATIVE COMPLICATIONS, COLON CANCER, STRICTURE, SURGICAL COMPLICATIONS, LEAKAGE, COMPLICATIONS | Traditionally, AC is initiated between 4 and 8 weeks after radical surgery for colon cancer to achieve the balance between postoperative recovery and therapeutic effect. Although many studies have reported a correlation between poor prognosis and late initiation of AC (more than 8 weeks postoperatively)In the era of mi... | PMC10338899 |
Supplementary Material | Click here for additional data file. | PMC10338899 | ||
Acknowledgements | J.Y.K. and J.S.P. contributed equally to this study as co-corresponding authors. K.H.L. and S.Y.P. contributed equally to this study as co-first authors. | PMC10338899 | ||
Funding | This study was supported by the International Colorectal Research Summit Grant 2015 and sponsored by the Korean Society of Coloproctology; the National Research Foundation of Korea (NRF). A grant was provided by the South Korean government (Ministry of Science and ICT, South Korea) (Grant No. 2021R1A5A2021614). | PMC10338899 | ||
Author contributions | Kyung Ha Lee (Investigation, Resources, Visualization, Writing—original draft, Writing—review & editing), Soo Yeun Park (Data curation, Formal analysis, Investigation, Resources, Software, Validation, Visualization, Writing—original draft), Seung Ho Song (Investigation, Writing—review & editing), Hye Jin Kim (Investiga... | PMC10338899 | ||
Disclosure | The authors declare no conflict of interest. | PMC10338899 | ||
Supplementary material | PMC10338899 | |||
Data availability | The data are available upon contact with the authors. | PMC10338899 | ||
References | PMC10338899 | |||
Subject terms | trunk flexor, Pain, Oswestry Disability, pain, lumbar multifidus muscle thickness, disability | SECONDARY | This study investigated the effectiveness of an early aquatic exercise program on trunk muscle function and functional recovery of patients with lumbar fusion. Twenty-eight subjects were divided into two equal groups. Patients in the aquatic group performed two 60-min aquatic exercise sessions and three 60-min home exe... | PMC10317955 |
Introduction | disability, stenosis, trunk muscle, pain | DEGENERATIVE CHANGE, STENOSIS | Lumbar fusion is a common spine surgery often performed to relieve symptoms related to spinal degenerative changes, stenosis, and spondylolisthesisExercise in water, compared with that on land, reduces loadTherefore, through this study, we aimed to examine the effects of an early aquatic rehabilitation program on pain,... | PMC10317955 |
Discussion | pain, disability, LM muscle thickness, lumbopelvic, trunk muscle function | To the best of our knowledge, this is the first study to investigate the effects of an early aquatic rehabilitation program on pain, disability, and trunk muscle function following lumbar spine fusion. Our data supported most of the hypotheses, with the 6-week aquatic rehabilitation program significantly improving trun... | PMC10317955 | |
Methods | PMC10317955 | |||
Trial design | This was an experimental, randomized controlled trial. Participants were randomly allocated to an experimental group or a control group for 6 weeks of intervention. This study was approved by the Institutional Review Board of Cheng Hsin General Hospital (425-103-02) and registered on 13/11/2016 at Thai Clinical Trials ... | PMC10317955 | ||
Participants | cardiovascular disease, cognitive dysfunction | CARDIOVASCULAR DISEASE, NEUROLOGICAL DISORDERS | Twenty-eight patients who underwent surgery with lumbar fusion and were referred from the Department of Orthopedics to the Department of Rehabilitation of the Cheng Hsin General Hospital for physiotherapy between October 2014 and December 2016 were recruited. Participants scheduled for first lumbar fusion surgery, thos... | PMC10317955 |
Sample size and randomization | Oswestry Disability | The sample size was calculated using the G*Power software, with alpha = 0.05 and 80% power for the outcome of the Oswestry Disability Index (ODI) by using the formula proposed by Abbott | PMC10317955 | |
Intervention | MAY, APPENDIX | Participants from both groups started the 6-week intervention 4 weeks after surgery. Those in the experimental group received two sessions of 60-min aquatic training, with three 60-min sessions of home exercises each week for 6 weeks, whereas those in the control group performed home exercises only (five 60-min session... | PMC10317955 | |
Outcome measures | disability, Pain, pain | SECONDARY, CONTRACTION | The primary outcomes were pain intensity and disability, and the secondary outcomes were mobility, muscle strength, lumbopelvic stability, and LM muscle thickness. The measurement of secondary outcomes and evaluation of exercise intervention were performed by the first author (AH Huang), and the primary outcomes were e... | PMC10317955 |
Statistical analysis | Data were analyzed using SPSS (version 20 for Mac; SPSS Inc., Chicago, IL, USA). Independent | PMC10317955 | ||
Supplementary Information | The online version contains supplementary material available at 10.1038/s41598-023-37237-3. | PMC10317955 | ||
Acknowledgements | This study was supported by a grant from Cheng Hsin General Hospital, Taipei, Taiwan (CH-104-18). This manuscript was edited by Wallace Academic Editing. The authors appreciate all participants for their contribution. | PMC10317955 |
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