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Types of studies
Observational studies such as analytical cross-sectional studies, case–control studies, and longitudinal studies (e.g., cohort studies) will be included for information on factors associated with PA participation among children. We will also include experimental study designs such as randomized controlled trials (RCTs)...
PMC10134558
Conceptual framework
We hypothesize several factors’ direct and indirect effects on PA participation in children through the conceptual framework (Fig. Conceptual Framework of direct and indirect factors effecting PA participation in childrenThe social factors also play an essential role in PA participation [Policy factors are another infl...
PMC10134558
Searching for studies
We will search Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed and Web of Science, Scopus, Excerpta Medica Database (EMBASE), Cumulated Index to Nursing and Allied Health Literature (CINAHL), The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Control...
PMC10134558
Selection of studies
Two reviewers (PS and ER) will independently screen the titles and abstracts of potential studies for eligibility based on the eligibility criteria of the review. Any disagreement at this stage will be resolved via discussion or in consultation with the third reviewer (SB). Full texts of all the included studies will b...
PMC10134558
Data management and extraction
Data will be managed using the EndNote reference manager and Microsoft Excel Office software. Data will be extracted by two review authors (PS and ER) independently by using the pre-tested data extraction sheet. All the reviewers will perform pilot testing of the data extraction sheet. Information related to bibliograp...
PMC10134558
Critical appraisal of the included studies risk of bias in individual studies
The reviewers will use the Cochrane Risk of Bias (ROB2) for assessing the quality of included RCTs [
PMC10134558
Measure of effects
If continuous, data will be reported as mean and standard deviation with a 95% confidence interval (CI). For categorical data, estimates of odds ratio (OR) and risk ratio (RR) with 95% CI will be used for reporting.Odds ratio will be extracted and reported for observational studies where the estimation of risk is diffi...
PMC10134558
Data synthesis
PMC10134558
For primary objective
Findings of the review will be presented via “the characteristics of included studies” and “summary of findings” table (as shown in Table 0 to 40%: might not be important30 to 60%: may represent moderate heterogeneity50 to 90%: may represent substantial heterogeneity75 to 100%: considerable heterogeneityRandom effects ...
PMC10134558
For secondary objective
The primary objective findings, i.e., the factors associated with PA participation among children will be used to frame the policy and practice recommendations. The different factors for PA participation will be listed, based on our contextual framework. Additionally, a list of recommendations present in the available ...
PMC10134558
Meta-biases
Funnel plots will be used for the identification of reporting or publication bias. The identification of reporting bias will be done based on a visual assessment of the funnel plot, where a symmetrical funnel plot will be interpreted as the absence of reporting bias and an asymmetrical plot will indicate the presence o...
PMC10134558
Discussion
obesity
OBESITY, DISEASES
Physical inactivity is one of the leading risk factors for lifestyle diseases and increased morbidity worldwide. PA is a modifiable factor and increasing PA levels among children can help reduce health risk factors, promote healthy lifestyles, and improve their quality of life.In this review, we expect to identify the ...
PMC10134558
Acknowledgements
We would like to acknowledge the Manipal Academy of Higher Education for technological and logistic support.
PMC10134558
Authors’ contributions
PS and ER conceptualized the topic. PS, ER, and SB drafted the manuscript. PS and ER edited and finalized the final version of the manuscript. All the authors (PS, ER, SB, VK, HVB) read, provided intellectual feedback, and approved the final version of the manuscript.
PMC10134558
Funding
No financial support from any commercial or non-commercial funders was done to support this systematic review.
PMC10134558
Availability of data and materials
Data sharing is not applicable to this protocol as datasets are not generated or analysed.
PMC10134558
Declarations
PMC10134558
Ethics approval and consent to participate
Not applicable.
PMC10134558
Consent for publication
Not applicable.
PMC10134558
Competing interests
The authors declare that they have no competing interests.
PMC10134558
References
PMC10134558
1. Introduction
obesity, Obesity, weight loss, bodyweight loss
OBESITY, OBESE, OBESITY
Although bariatric surgery is known to change the metabolome, it is unclear if this is specific for the intervention or a consequence of the induced bodyweight loss. As the weight loss after Roux-en-Y Gastric Bypass (RYGB) can hardly be mimicked with an evenly effective diet in The prevalence of obesity has nearly trip...
PMC9916678
2. Results
PMC9916678
2.1. Participants from the WAS Trial
weight loss
Characteristics of the patient cohort at the start of the study have been described in detail previously [At 1-year follow-up patients of the RYGB-surgery group achieved a significant weight loss of −34.3% (BMI 49.1 [46–51] kg/mA total of 188 metabolites were measured in 46 serum samples at randomization and one year a...
PMC9916678
2.2. Rodent Model
Characteristics of the rodent model have been described in detail previously [Further analysis of these metabolites (2 acylcarnitines, 6 amino acids, 2 biogenic amine, 3 lysoPCs, 41 PCs and 8 sphingolipids) with PCA showed that the first two components explained 74% of the variance. PC1 was mainly characterized by phos...
PMC9916678
2.3. Analysis of Overlapping Metabolomic Profiles in the Human OP and the Rat RYGB Group
Thirty-one metabolites with significant differences in both OP vs. LS and RYGB_rat vs. BWM_rat could be identified (see In terms of individual metabolites, six amino acids with a significant difference between RYGB_rat and BWM_rat were also found to be significantly different in the Analyzing the phosphatidylcholines w...
PMC9916678
3. Discussion
obesity, weight loss
OBESITY, SEPARATION
The aim of our study was to identify and characterize a comprehensive metabolomic profile, which highlights the effect of bariatric surgery on the metabolome beyond weight loss. Whereas patients of the WAS intensified lifestyle group failed to lose weight significantly, patients with bariatric surgery lost a significan...
PMC9916678
4. Materials and Methods
PMC9916678
4.1. Patients
OBESE
The Würzburg Adipositas Study is a randomized trial comparing the effects of RYGB vs. psychotherapy-enhanced lifestyle intervention not including calorie-limited nutrition in morbidly obese patients. Details of the design of the study are published elsewhere [
PMC9916678
4.2. Animals
As described in detail elsewhere, adult male Wistar
PMC9916678
4.3. Laboratory Measurements
In brief, serum samples from patients were obtained upon enrolment under standardized conditions. After an overnight fast, the blood was drawn from the cubital vein with a Safety-MultiflyPlasma samples from
PMC9916678
4.4. Targeted Metabolomics
Reagents, standards and controls were prepared according to manufacturer’s instructions (Biocrates UM-P180-SCIEX-13) for mass spectrometry. Analytical columns (Acquity UPLC BEH C18 1.7 µm 2.1 mm × 75 mm, Waters) and pre-column (Acquity BEH C18 1.7 VANGUARD) from Waters (Eschborn, Germany) were used. Targeted metabolomi...
PMC9916678
4.5. Statistical Analysis
Analyses were conducted using SPSS software (PASW version 25.0, SPSS Inc. Chicago, IL, USA), GraphPad Prism version 9.1.2 for Windows (GraphPad Software, La Jolla, CA, USA) and MetaboAnalyst (version 5.0, Clinical data of the WAS cohort was not normally distributed (Shapiro–Wilk test, Data in the rodent model were norm...
PMC9916678
5. Conclusions
OBESE
We analyzed the effects of surgical vs. lifestyle intervention on the serum metabolome of obese and insulin resistant
PMC9916678
Supplementary Materials
The following supporting information can be downloaded at: Click here for additional data file.
PMC9916678
Author Contributions
Conceptualization, U.D., I.B. and M.F.; methodology, M.K. and I.B.; software, M.K. and U.D.; validation, U.D., M.K. and M.F.; formal analysis, I.B.; investigation, U.D.; resources, M.F., A.-C.K., C.S. and U.D.; data curation, M.K.; writing—original draft preparation, I.B.; writing—review and editing, U.D., M.F., M.K., ...
PMC9916678
Institutional Review Board Statement
The WAS study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the University Hospital of Wuerzburg (182/08, approved on 16 December 2014). The rodent model was conducted according to the guidelines of the Declaration of Helsinki and approved by the local regulatory ...
PMC9916678
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
PMC9916678
Data Availability Statement
Data are contained within the article or
PMC9916678
Conflicts of Interest
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
PMC9916678
References
Unsupervised principal component analysis of 57 significantly different metabolites between lifestyle intervention and surgery group in the WAS cohort at 1-year follow-up. The first component explains 32% of the variation, and the second component 17%. C, acylcarnitine; lysoPC, lysophosphatidylcholine; PC aa, phosphati...
PMC9916678
2. Materials and Methods
PMC10384820
2.1. Study Design
This was an assessor-blind three-armed randomized controlled trial (clinicaltrials.gov number: NCT05680467) conducted under the supervision of the Department of Physiotherapy of the International Hellenic University during the period December 2022–March 2023. Ethical approval was granted by the Ethics Committee of the ...
PMC10384820
2.2. Participants
diagnosed neurodegenerative diseases, neuropathic pain, Pain, epilepsy, cancer, fracture, systemic musculoskeletal diseases, psychiatric, Parkinson’s, trauma
CANCER, NERVE ROOT COMPRESSION, DISORDERS, EPILEPSY
The inclusion criteria of the participants were (1) duration of symptoms longer than 12 weeks, (2) Numeric Pain Rating Scale (NPRS) score higher than 3 during the baseline assessment, and (3) written consent to participate in the research. The exclusion criteria of the participants were (1) neuropathic pain extending a...
PMC10384820
2.3. Outcome Measures
The following measurements were performed at the beginning (baseline), after two weeks, and at a one-month follow-up. Participants of both intervention groups attended a total of six sessions (three sessions per week). Each session lasted 30 min. All outcome measurements were considered primary.
PMC10384820
2.3.1. Pain with the Numeric Pain Rating Scale (NPRS)
pain
The NPRS is an 11-point pain scale numbered from 0 to 10. The left end of the scale is marked 0 with the phrase “no pain at all”, while the right end is marked 10 with “worst possible pain”. Therefore, a higher value corresponds to more intense pain [
PMC10384820
2.3.2. Functional Ability with the Roland–Morris Disability Questionnaire (RMDQ)
low back pain, disability
The disability of participants related to CNSLBP was evaluated with the Greek version of the Roland–Morris Questionnaire (RMDQ). The RMDQ consists of 24 questions related to daily activities that patients often report difficulty performing due to low back pain [
PMC10384820
2.3.3. Pressure Pain Threshold (PPT) with Pressure Algometry
sacroiliac joints, pain
Pressure pain threshold (PPT) is defined as the minimal amount of pressure that produces pain. The PPT assessment was performed with a digital algometer (Wagner FPX 25 Digital Algometer; Wagner Instruments, Greenwich, CT, USA) bilaterally in the quadratus lumborum muscle, in the sacroiliac joints, and paravertebrally i...
PMC10384820
2.3.4. Lumbo-Pelvic Region Mobility with the Fingertip-to-Floor (FTF) Test
lumbar spine flexion
Changes in the lumbar spine flexion range of motion were evaluated with the Fingertip-To-Floor (FTF) test [
PMC10384820
2.4. Experimental Protocols
PMC10384820
2.4.1. Manual Therapy (MT) Protocol
The protocol included the application of a series of MT soft tissue techniques for the lumbar area as suggested by Kaltenborn [
PMC10384820
2.4.2. Manual Therapy with TECAR (MT + TECAR) Protocol
TECAR
The participants of this group followed the same MT protocol as the first group with the addition of high-frequency current with the WinBack—TECAR device (WINBACK 3SE, Villeneuve Loubet, France). Soft tissue mobilization manipulations were applied in combination with a capacitive conventional electrode (6 cm diameter) ...
PMC10384820
2.4.3. Control
pain
Participants in this group received general instructions about managing their back pain and counseling about avoiding activities that may worsen their symptoms.
PMC10384820
2.5. Sample Size Determination
A total sample size of at least 45 subjects was calculated based on an a priori power analysis (G*Power 3.0.10). As a basic prerequisite for this calculation, the power (1-β) was set at 95% and the detection of a difference in the order f = 0.5 (Cohen’s f) [
PMC10384820
2.6. Statistical Analysis
Data were analyzed using SPSS Statistics for Windows, version 25.0 (SPSS Inc., Chicago, IL, USA). Normal distribution was checked using the Shapiro–Wilk test and Q-Q and P-P plots. To analyze the data, a two-way analysis of variance (ANOVA) with repeated measures was conducted. The ANOVA was applied to examine the inte...
PMC10384820
3. Results
During December 2022, a total of 78 persons were screened for eligibility. Sixty of them (76.9%) met the inclusion criteria and were randomly allocated into one of the three groups (
PMC10384820
3.1. NPRS Score
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the NPRS score in the two-way ANOVA analysis (
PMC10384820
3.2. RMDQ Score
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the RMDQ score in the two-way ANOVA analysis (
PMC10384820
3.3. PPT of L4-L5 Paraspinal Intervertebral Space
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the right PPT of L4-L5 paraspinal intervertebral space in the two-way ANOVA analysis (
PMC10384820
3.4. Sacroiliac Joint PPT
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the right PPT of the sacroiliac joint in the two-way ANOVA analysis (
PMC10384820
3.5. Quadratus Lumborum Muscle PPT
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the right quadratus lumborum muscle PPT in the two-way ANOVA analysis (
PMC10384820
3.6. FTF Test Score
The statistical analysis revealed a significant interaction effect between “Group” and “Time” for the FTF test score in the two-way ANOVA analysis (
PMC10384820
4. Discussion
tightness, low back pain, sacroiliac joint dysfunction, pain
HEAT, BENDING, SACROILIAC JOINT DYSFUNCTION
In our research, the same MT protocol was applied with and without the application of a TECAR high-frequency current to investigate whether the simultaneous application of the two methods could be more effective, compared to the individual application of MT, in the treatment of symptoms in people with CNSLBP. Modern TE...
PMC10384820
5. Conclusions
disability, pain
The application of an MT protocol with TECAR using a resistive special bracelet electrode seems to improve pain and disability further than conventional MT in individuals with CNSLBP. The positive effect seems to be due to the combination of mechanical and thermal effects offered simultaneously by the two therapeutic m...
PMC10384820
Author Contributions
D.L.
Conceptualization, K.K., P.I., D.L., G.K. and T.A.; methodology, I.P.C., G.K., D.L., P.I., A.F. and G.T.; software, I.P.C., D.L., N.-M.K., A.S. and T.A.; validation, I.P.C., D.L. and G.C.; formal analysis, I.P.C., K.K. and G.T.; investigation, G.K., K.K., A.F., S.R.N. and P.I.; resources, G.K., I.P.C., D.L., P.I., K.K....
PMC10384820
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Department of Physiotherapy of the International Hellenic University (No. EC-06/2022).
PMC10384820
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
PMC10384820
Data Availability Statement
The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
PMC10384820
Conflicts of Interest
The authors declare no conflict of interest.
PMC10384820
References
MT protocol with TECAR: (CONSORT flow diagram of the study.Demographic characteristics of the three groups.MT = manual therapy; MT + TECAR = manual therapy plus TECAR.The mean (SD) values of the outcome measures for each time point for the three groups. The “Group” × “Time” interaction Between-group comparison: a = Gro...
PMC10384820
1. Introduction
infection
CORONAVIRUS, INFECTION, CORONAVIRUS DISEASE 2019, SEVERE ACUTE RESPIRATORY SYNDROME
These authors contributed equally to this work.Despite the effectiveness and safety of COVID-19 vaccines, vaccine-induced responses decline over time; thus, booster vaccines have been approved globally. In addition, interest in natural compounds capable of improving host immunity has increased. This study aimed to exam...
PMC10097014
2. Materials and Methods
PMC10097014
2.1. Study Design and Participants
This longitudinal study evaluated KRG intake’s effect on COVID-19 antibodies after vaccination in Korean adults (Clinical Research Information Service, KCT0007342). The study was approved by the Institutional Review Board of Yongin Severance Hospital (IRB no. 9-2021-0101) and was conducted in compliance with the Declar...
PMC10097014
2.2. Study Outcomes
diabetes, psychiatric, angina, cardiovascular diseases
MALIGNANT TUMORS, DIABETES, MYOCARDIAL INFARCTION, STROKE, CARDIOVASCULAR DISEASES
The inclusion criteria for this study included the following: adults aged 30 years or older, participants who had taken red ginseng for at least one month within the last month prior to vaccination (KRG group), and individuals who had not taken red ginseng for two or more months before vaccination (control group). Subj...
PMC10097014
2.3. Measurement of Anthropometric and Biochemical Parameters
hypertension, diabetes
DIABETES, HYPERTENSION, -20
Participants underwent five examinations: at baseline; 2, 4, and 12 weeks after their second COVID-19 vaccination, and 4 weeks after their third vaccination. At each visit, body weight, height, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded. Height and weight were obtained with subjects...
PMC10097014
2.4. Detection of Virus-Specific Antibodies
VIRUS
Automated ECLIA tests were performed with two types of SARS-CoV-2 antibody kits using the Cobas 8000 e801 module (Roche Diagnostics). The Elecsys Anti-SARS-CoV-2 assay (Roche Diagnostics) uses a recombinant protein representing the nucleocapsid (NC) antigen for the qualitative detection of antibodies against SARS-CoV-2...
PMC10097014
2.5. Statistical Analysis
Data are shown as the means ± standard deviations for continuous variables and frequency (percentage) for categorical variables. Statistical significance for differences in baseline characteristics between the KRG and control groups was analyzed using independent Longitudinal antibody data were analyzed using the linea...
PMC10097014
3. Results
A total of 350 subjects who received three COVID-19 vaccines participated in this study. Subjects were allocated to the KRG group (Pearson’s correlation analysis was used to evaluate the association of anti-N-Ab and other covariates four weeks after the first dose (baseline). Age and vitamin D level were inversely corr...
PMC10097014
4. Discussion
PROLIFERATION, INFLAMMATION
In this study, vaccine-induced humoral responses in both the KRG and control groups significantly increased two weeks after the second administration of all vaccines; then, a decrease was observed until 12 weeks or just before booster vaccination. However, after booster vaccination, humoral responses increased again; t...
PMC10097014
5. Conclusions
The protection against COVID-19 tends to decline over time after vaccination. This study showed the potential of KRG for boosting immunity and helping maintain a higher vaccine-induced humoral response after COVID-19 vaccination. Further studies will be needed to explain the mechanisms of these relationships in detail.
PMC10097014
Author Contributions
Conceptualization, J.Y., B.P., H.K., S.C. and D.J.; methodology, S.C. and H.K.; formal analysis, D.J.; investigation, J.Y., B.P., H.K., S.C. and D.J.; data curation, D.J.; writing—original draft preparation, J.Y., S.C. and D.J.; writing—review and editing, J.Y. and D.J.; supervision, D.J. All authors have read and agre...
PMC10097014
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Yongin Severance Hospital (IRB No. 9-2021-0101).
PMC10097014
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
PMC10097014
Data Availability Statement
All data generated or analyzed during this study are available from the corresponding author upon proper request.
PMC10097014
Conflicts of Interest
The authors declare no conflict of interest.
PMC10097014
Abstract
PMC9854322
Background
cancer
CANCER
Health literacy plays an essential role in how individuals process health information to make decisions about health behaviours including cancer screening. Research is scarce to address health literacy as a strategy to improve cancer screening participation among women living with human immunodeficiency virus (HIV), pa...
PMC9854322
Aim
CERVICAL CANCER
To assess the feasibility, acceptability and preliminary efficacy of a health literacy‐focused intervention called CHECC‐uP—Community‐based, HEalth literacy focused intervention for Cervical Cancer control—among women living with HIV.
PMC9854322
Methods
CERVICAL CANCER
We conducted a community‐based, single‐blinded randomized pilot trial. A total of 123 eligible women were enrolled and randomized to one of two conditions, control (i.e., cervical cancer brochure) or intervention (cervical cancer brochure plus 30–60 min health literacy‐focused education followed by monthly phone counse...
PMC9854322
Results
All intervention participants who completed the programme would recommend the CHECC‐uP to other women living with HIV. However, adherence in the experimental conditions was low (49.6% attrition rate including 20 women who dropped out before the intervention began) due, in large part, to phone disconnection. Those who h...
PMC9854322
Conclusions
The CHECC‐uP was highly acceptable and led to improved Pap testing rates among Black women living with HIV. Future research should consider addressing social determinants of health such as phone connectivity as part of designing a retention plan targeting low‐income Black women living with HIV.
PMC9854322
Implications
The findings should be incorporated into a future intervention framework to fulfil the unmet needs of Black women living with HIV to facilitate their decision‐making about Pap test screening.
PMC9854322
Patient or Public Contribution
CERVICAL CANCER
Nineteen community members including women living with HIV along with HIV advocates and care providers participated in four focus groups to develop cervical cancer screening decision‐relevant information and the health literacy intervention. Additionally, a community advisory board was involved to provide guidance in t...
PMC9854322
INTRODUCTION
cancer
CANCER, VIRUS, CERVICAL CANCER, CERVICAL CANCER
Despite considerable progress in US cancer control over the past decades, certain groups continue to experience significant health disparities. Women living with human immunodeficiency virus (HIV) (WLH) experience a disproportionate cervical cancer burden because of an impaired immune response to the human papillomavir...
PMC9854322
METHODS
PMC9854322
Design and sample
HIV
We used a community‐based, randomized controlled trial design to pilot test the CHECC‐uP intervention compared to an educational control (Clinical Trials Registry NCT03033888). Women were recruited from inner‐city HIV clinics, community organizations serving people with HIV or a university‐based HIV/AIDS research centr...
PMC9854322
Randomization and intervention
HIV, human immunodeficiency virus
CERVICAL CANCER
We used computer‐generated random numbers to randomize women to either the intervention or control arm. The control arm received an educational brochure related to cervical cancer among WLH created for the purpose of the study. Women in the intervention arm received the educational brochure plus the study intervention,...
PMC9854322
Procedures
CERVICAL CANCER
The Johns Hopkins Institutional Review Board approved the study protocol. Once eligible women were identified, trained research assistants scheduled a visit to obtain written informed consent and collect baseline data at several community sites (e.g., nurse‐run community health centres or community organizations servin...
PMC9854322
Measures
Depressive, cancer, PHQ‐9, depressive, depression, breast and cervical cancer, Cancer
CANCER, RECRUITMENT, CERVICAL CANCER, CERVICAL CANCER, CANCER
A study questionnaire was used to collect participants sociodemographic and medical characteristics. Data regarding Pap test status were assessed via medical record review. We used several study instruments to assess changes in WLH's psychosocial outcomes: Health literacy, cancer knowledge, self‐efficacy, cultural beli...
PMC9854322
Statistical analyses
Analysis was performed using data from the 58 participants who completed all data points and whose Pap test status was confirmed objectively by medical records (Figure
PMC9854322