title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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REFERENCES | PMC10076092 | |||
Background | DISEASE, TRIGGER FINGER, TRIGGER FINGER | Trigger finger is a common disease with a lifetime prevalence of 2%. One of the frequently preferred non-surgical treatments is blinded injection around the A1 pulley. This study aims to compare the clinical results of ultrasound-guided and blinded corticosteroid injection in the trigger finger.
| PMC10294380 | |
Methods | TRIGGER FINGER, COMPLICATIONS | In this prospective clinical study, 66 patients who had persistent symptoms of a single trigger finger were included. Patients with similar baseline characteristics such as age, gender, triggering period, and comorbidities were randomized. 34 patients had ultrasound-guided (UG), and 32 had blinded injections (BG). QDAS... | PMC10294380 | |
Results | The mean age was 52,66 (29–73) years. There were 18 male and 48 female patients. In the UG, the triggering resolved faster, returning to work was earlier, and the medication period was shorter ( | PMC10294380 | ||
Conclusion | TRIGGER FINGER | Using ultrasound guidance for corticosteroid injections is more effective for treating trigger fingers than the blinded method, leading to better results and a faster return to work in the early stages of treatment. | PMC10294380 | |
Keywords | PMC10294380 | |||
Background | inflammation | INFLAMMATION, TRIGGER FINGER, HAND SWELLING | Trigger finger (TF) is the inflammation and swelling of the retinacular sheath that gradually restricts the mobility of flexor tendons [ | PMC10294380 |
Materials and methods | finger contracture | RHEUMATOID ARTHRITIS, NEUROLOGICAL DISEASE, TRIGGER FINGER, DISEASES, COMPLICATIONS | The present study was designed as a prospective controlled study and initiated upon the approval of the local ethics committee. The present study included successive patients with Quinnel stage 2,3 or 4 trigger fingers who did not respond to the conservative treatment (splint, non-steroidal anti-inflammatory, drugs and... | PMC10294380 |
Statistical analysis | Excel (Microsoft Corporation, WA, USA) was used to collect and manage the study data, and SPSS version 24.0 (IBM Corporation, Armonk, NY, USA) was used to perform data analyses. The quantitative data were presented as mean ± standard deviation, whereas the qualitative data were presented as frequencies with percentages... | PMC10294380 | ||
Author contributions | MT: Design of the work, drafting the work, approval of the version to be published, agreement to be accountable for all aspects of the work. KT: Interpretation of data for the work, revising the work critically for important intellectual content, approval of the version to be published, agreement to be accountable for ... | PMC10294380 | ||
Funding | There is no funding source. | PMC10294380 | ||
Availability of data and materials | Not applicable. | PMC10294380 | ||
Declarations | PMC10294380 | |||
Competing interests | The authors declare no competing interests. | PMC10294380 | ||
Ethics and consent to participate | This study was approved by the institutional review board of the No. 2/2020.K-060 of Istinye University. | PMC10294380 | ||
Competing interest | On behalf of all authors, the corresponding author states that there is no conflict of interest. | PMC10294380 | ||
References | PMC10294380 | |||
Background | postoperative gastrointestinal hypokinesis, Gastrointestinal hypokinesis | SIDE EFFECT | Gastrointestinal hypokinesis can occur transiently after benign gynecologic surgery. Opioids cause the side effect of postoperative gastrointestinal hypokinesis, but an opioid-sparing anaesthetic protocol based on esketamine reduces intraoperative opioid consumption. Therefore, this study hypothesised that an opioid-sp... | PMC10288755 |
Methods | PONV | This was a prospective randomized controlled double-blind study conducted in a single centre. All patients scheduled for elective benign laparoscopic gynaecological surgery at Xing’an Meng People’s Hospital, Inner Mongolia Autonomous Region, from November 2021 to April 2022 were consecutively enrolled and randomly divi... | PMC10288755 | |
Results | intraoperative bleeding | INTRAOPERATIVE BLEEDING | A total of 71 patients were enrolled in this study, including 35 in Group OS and 36 in Group C. The general condition, operative time, type of surgery, intraoperative bleeding, intraoperative fluid volume and intraoperative urine volume were not statistically different between the two groups. Compared with Group C, sig... | PMC10288755 |
Conclusion | PONV | The esketamine-based opioid-sparing anaesthetic protocol can shorten the postoperative first flatus time after benign laparoscopic surgery in gynaecology, and reduce the incidence of PONV. In addition, the application of esketamine may reduce the postoperative opioid dose requirement of patients. | PMC10288755 | |
Trial registration | : This study was registered with the China Clinical Trials Registry (registration number: ChiCTR2100052528, 30/10/2021). | PMC10288755 | ||
Keywords | PMC10288755 | |||
Introduction | POI, gastrointestinal hypokinesis, trauma | POSTOPERATIVE INTESTINAL OBSTRUCTION, INTRAOPERATIVE BLOOD LOSS | Benign gynecologic surgery, including laparoscopic surgery, is associated with transient gastrointestinal hypokinesis leading to postoperative intestinal obstruction (POI) [Previous studies have shown that the incidence of POI is associated with operative time, intraoperative blood loss, surgical trauma, intestinal man... | PMC10288755 |
Methods | allergy | ALLERGY | This prospective randomized double-blinded clinical trial, which adhered to CONSORT guidelines, was approved and was performed from November 2021 to April 2022, in accordance with the Helsinki Declaration of the World Medical Association. The study was reviewed and approved by the Medical Ethics Committee of Xi’an Leag... | PMC10288755 |
Blinding and randomisation method | In this study, patients were randomly grouped using computer-generated random numbers, and the results of the grouping were kept in sealed opaque envelopes. After obtaining informed consent from the patients, the nurse opened the envelope and divided the patients into either the opioid-sparing anesthesia group (OS grou... | PMC10288755 | ||
Anaesthesia method | µg.kgPropofol, NRS, pain | INFILTRATION | All patients fasted for 6–8 h and abstained from drinking for 4 h. After patients entered the operating room, intravenous access was routinely opened, oxygen was administered by face mask, and heart rate, noninvasive blood pressure, bispectral index (BIS), respiration, and oxygen saturation were continuously monitored.... | PMC10288755 |
Outcomes and data collection | PONV, dizziness, nausea and/or vomiting, pain | SECONDARY | The primary endpoint of this study was the time of first postoperative flatus. Secondary endpoints were anaesthesia resuscitation time, postoperative first feeding time, postoperative nausea and/or vomiting (PONV) incidence, dizziness, postoperative numerical rating scale (NRS) of pain and hospital days postoperatively... | PMC10288755 |
Statistical analysis | SD | Based on the results of the pretest, the time to first postoperative expulsion was 17.2 ± 6.9 h for patients receiving the opioid-sparing anaesthesia protocol and 27.1 ± 16.2 h for patients receiving the conventional anaesthesia protocol. Taking a test efficacy of 90% and α as 0.05, a sample size of 35 cases per group ... | PMC10288755 | |
Results | postoperative nausea and/or vomiting, bleeding, abdominal adhesions, pain, PONV, NRS | ADVERSE REACTIONS, BLEEDING | A total of 94 consenting patients participated in this study from November 2021 to April 2022 at Xing’an Meng People’s Hospital, Inner Mongolia Autonomous Region. Among them, 9 patients had their surgical plan changed to gynaecological surgery with appendectomy on the day of surgery and 7 preoperative patients declined... | PMC10288755 |
Acknowledgements | We thank the anesthesiologists and nurses involved in intraoperative anesthesia at the Department of Anesthesiology, Xing’an League People’s Hospital, Inner Mongolia Autonomous Region. | PMC10288755 | ||
Authors’ contributions | Yuhua Ma: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Writing - Original Draft and Supervision. Xue Cao, Lin Zhang, Suozhu Bao, Jie Ren and Weiwei Ma: Resources and Data Curation. Ran Zhang: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Writing - Review & Ed... | PMC10288755 | ||
Funding | Support was provided solely from institutional and/or departmental sources. | PMC10288755 | ||
Data Availability | The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.Data supporting the results of this study are available from the Xing’an Meng People’s Hospital, Inner Mongolia Autonomous Region, but the availability of these data is restricted and they are us... | PMC10288755 | ||
Declarations | PMC10288755 | |||
Ethics approval and consent to participate | The study was reviewed and approved by the Medical Ethics Committee of Xi’an League People’s Hospital, Inner Mongolia Autonomous Region (approval number: YJXM2021YB2, 25/09/2021, Chairman: Hui Jiang). All patients signed an informed consent form. This prospective randomized double-blinded clinical trial, which adhered ... | PMC10288755 | ||
Consent for publication | Not applicable. | PMC10288755 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10288755 | ||
References | PMC10288755 | |||
Background | Dexmedetomidine, one of the sedatives, has an analgesic effect. We aimed to investigate postoperative analgesia with dexmedetomidine as adjuvants for procedural sedation using perfusion index (PI). | PMC10214613 | ||
Methods | NRS, pain | In this prospective, randomized, case-control, observational study, 72 adult patients, 19–70 years, who were scheduled for chemoport insertion under monitored anesthesia care were performed. According to the group assignment, remifentanil or dexmedetomidine was simultaneously infused with propofol. The primary outcome ... | PMC10214613 | |
Results | During PACU staying, PI values were significantly different between the two groups PI values at 30 min after admission to the PACU were 1.3 (0.9–2.0) in the remifentanil group and 4.5 (2.9–6.8) in the dexmedetomidine group (median difference, 3; 95% CI, 2.1 to 4.2; | PMC10214613 | ||
Conclusion | postoperative pain, pain | We could not find a significant correlation between PI and NRS score for postoperative pain control. Using PI as a single indicator of pain is insufficient. | PMC10214613 | |
Trial registration | Clinical Trial Registry of Korea, | PMC10214613 | ||
Keywords | PMC10214613 | |||
Introduction | Monitored anesthesia care is an anesthetic method applied in relatively simple surgeries, especially in ambulatory surgeries that do not require hospitalization. For adequate sedation, anesthesiologists choose various combinations of sedatives and analgesics. Remifentanil, a µ-opioid, is widely used to induce anesthesi... | PMC10214613 | ||
Materials and methods | PMC10214613 | |||
Ethics approval and consent to participate | -11, RECRUITMENT | This prospective, randomized, case-control, observational study was approved by the Samsung Medical Center Institutional Review Board, Samsung Medical Center, Seoul, Republic of Korea (Chairperson: Prof. Young Keun On) on 6th, December 2018 (no. SMC 2018-11-111). Prior to the recruitment of the first participants, we r... | PMC10214613 | |
Patients and protocols | allergy | ALLERGY | Adult patients aged 19–70 years with American Society of Anesthesiologists physical status I and II scheduled for elective chemoport insertion under monitored anesthesia care were assessed for eligibility and were included between February 2019 and December 2019. Exclusion criteria were allergy to certain anesthetic ag... | PMC10214613 |
Randomization and group allocation | One statistician who was not involved in this trial generated a random allocation sequence using permuted-block randomization with a block size of 4. Randomization and group allocation were performed in a 1:1 ratio using the sealed opaque envelope technique. The study drugs were prepared in a 20 ml syringe depending on... | PMC10214613 | ||
Remifentanil group | remifentanil 1 mg (Remiva Inj., Remifentanil Hydrochloride, Hana Pharm Co., Ltd.) + 0.9% saline 20 ml. | PMC10214613 | ||
Dexmedetomidine group | dexmedetomidine 80 μg (premixed solution of 4 mcg/ml) (Precedex Inj. Dexmedetomidine Hydrochloride, Pfizer Ltd.) | PMC10214613 | ||
Protocol | Pain, pain | Premedication was not permitted for all participants. The prepared study drug was delivered to a clinical anesthesiologist (unrelated to this study) just before the start of anesthesia induction. On arrival in the operating room, standard monitors, including electrocardiograms, pulse oximetry, and noninvasive blood pre... | PMC10214613 | |
Outcomes | NRS | SECONDARY | The primary outcome was the comparison of PI values 30 min after admission to the PACU. To evaluate the lasting effect of the anesthetic used during sedation, PI measurement time of the primary outcome was set to 30 min after entering the PACU. The secondary outcomes were the comparison of NRS scores and PI values acco... | PMC10214613 |
Statistical analysis | NRS | The sample size was calculated based on unpublished clinical data. The mean (standard deviation) of PI value at 30 min after entering PACU was 2.81 (1.88) in dexmedetomidine group and 1.5 (1.38) in remifentanil group. To evaluate this at a significance level of 5% and power of 90%, we needed 35 patients in each group. ... | PMC10214613 | |
Acknowledgements | Not applicable. | PMC10214613 | ||
Author contributions | Doyeon Kim: helped with study concept development, study design, data collection, data analysis and interpretation, writing and drafting the article, and revising the manuscript.-Changjin Lee: helped with data analysis, and interpretation.-HanWool Bae: helped with data analysis, and interpretation.-Jeayoun Kim: helped ... | PMC10214613 | ||
Funding | Not applicable. | PMC10214613 | ||
Data availability | The data associated with the paper are not publicly available but are available from the corresponding author on reasonable request. | PMC10214613 | ||
Declarations | PMC10214613 | |||
Competing interests | The authors declare that they have no competing interests. | PMC10214613 | ||
Ethics approval and consent to participate | -11, RECRUITMENT | This prospective, randomized, cohort observational study was approved by the Samsung Medical Center Institutional Review Board, Samsung Medical Center, Seoul, Republic of Korea (Chairperson: Prof. Young Keun On) on 6th, December 2018 (no. SMC 2018-11-111). Prior to the recruitment of the first participants, we register... | PMC10214613 | |
Consent for publication | Not applicable. | PMC10214613 | ||
Previous presentation | Not applicable. | PMC10214613 | ||
References | PMC10214613 | |||
Key Points | PMC10015302 | |||
Question | Is there an association between standardized e-cigarette packaging and interest in trying e-cigarette products among samples of youths and adults in Great Britain? | PMC10015302 | ||
Findings | In this study comprising 2 surveys conducted among 2469 youths (aged 11-18 years) and 12 046 adults (aged ≥18 years) from Great Britain, youths had higher odds of reporting no interest in trying e-cigarettes in standardized green packaging than e-cigarettes in branded packaging, but adults had lower odds of reporting n... | PMC10015302 | ||
Meaning | This study suggests that standardized packaging measures may reduce the appeal of e-cigarettes among youths without reducing their appeal among adults. | PMC10015302 | ||
Importance | e-Cigarette vaping among youths and adults has increased in Great Britain. The design of e-cigarette packaging may appeal to youths. Regulations that reduce the appeal of e-cigarettes to youths may deter adult smokers from trying e-cigarettes to help them quit smoking. | PMC10015302 | ||
Objective | To examine the association of fully branded and standardized e-cigarette packaging with interest in trying products among youths and adults in Great Britain. | PMC10015302 | ||
Design, Setting, and Participants | In this survey study comprising 2 surveys, the online Action on Smoking and Health Smokefree Great Britain survey collected data between March 25 and April 16, 2021, from a representative sample of 2469 youths (aged 11-18 years) and between February 18 and March 18, 2021, from a representative sample of 12 046 adults (... | PMC10015302 | ||
Interventions | A between-individuals experimental design was used to examine participants’ perceptions of e-cigarette packs that were digitally altered to remove brand imagery and color. Participants were randomly assigned to view a set of 3 e-cigarette packs from 1 of 3 different packaging conditions: (1) fully branded packs (contro... | PMC10015302 | ||
Main Outcomes and Measures | REGRESSION | Youth participants were asked which product people their age would be most interested in trying, while adult participants were asked which product they would be most interested in trying. All participants could respond “no interest” or “don’t know.” Logistic regression models tested whether reporting no interest in try... | PMC10015302 | |
Results | This study included 2469 youths (1286 female youths [52.1%]; mean [SD] age, 15.0 [2.3] years) and 12 046 adults (6412 female [53.2%]; mean [SD] age, 49.9 [17.4] years). Youths had higher odds of reporting no interest among people their age in trying the e-cigarettes packaged in green (292 of 815 [35.8%]; adjusted odds ... | PMC10015302 | ||
Conclusions and Relevance | The findings of this survey study suggest that standardized packaging measures may reduce the appeal of e-cigarettes among youths without reducing their appeal among adults.This survey study examines the association of fully branded vs standardized e-cigarette packaging with interest in trying products among youths and... | PMC10015302 | ||
Introduction | MAY | In Great Britain in 2022, 8.3% of adults and 7.0% of youths aged 11 to 17 years reported current vaping.e-Cigarette marketing, including packaging, has been found to influence the appeal of vaping products to youth and adult smokers.Standardized (or “plain”) packaging for combustible tobacco cigarettes was introduced i... | PMC10015302 | |
Methods | PMC10015302 | |||
Data Sources | SECONDARY, ASH | The data provided in this survey study were obtained from 2 online surveys: the Action on Smoking and Health (ASH) 2021 Smokefree Great Britain Youth Survey and the ASH 2021 Smokefree Great Britain Adult Survey. For the youth survey, informed consent was provided either by the parents of those aged 11 to 15 years or by... | PMC10015302 | |
ASH Youth Survey | ASH | The online 2021 ASH Smokefree Great Britain Youth Survey collected data from young people aged 11 to 18 years between March 25 and April 16, 2021. Participants were drawn from an existing online panel maintained by YouGov. Active sampling was used, which dynamically evaluates what surveys are available for a particular... | PMC10015302 | |
e-Cigarette Packs by Experimental Condition | The green standardized pack color, using the same olive-green Pantone 448 C shade in a matte finish, was chosen to reflect the current standardized packaging requirements for tobacco cigarette packs in Great Britain.The survey was completed by 2513 youths. Respondents who reported “Prefer not to say” for the outcome (n... | PMC10015302 | ||
No Interest in Trying e-Cigarette Products Among People Your Age (Outcome) | Respondents were shown a set of 3 e-cigarette packs based on experimental condition ( | PMC10015302 | ||
Vaping Status | Respondents were asked, “Have you ever heard of e-cigarettes? They are also sometimes called vapes, shisha pens or electronic cigarettes.” Those who responded “Yes” were asked “Which ONE of the following is closest to describing your experience of e-cigarettes?” with available responses ranging from “I have never used ... | PMC10015302 | ||
Smoking Status | Respondents were asked which statement best applied to their experience with cigarettes. Response options were classified into 3 categories: “never smoker,” “ever smoker,” and “current smoker” (including occasional and regular smoking) (eTable 1 in | PMC10015302 | ||
ASH Adult Survey | ASH | The online 2021 ASH Smokefree Great Britain Adult Survey collected data on tobacco and vaping product use among adults aged 18 years or older between February 18 and March 18, 2021. Like the ASH Youth Survey, participants were drawn from an existing online panel maintained by YouGov using active sampling. The experimen... | PMC10015302 | |
No Interest in Trying e-Cigarette Products (Outcome) | Respondents were shown a set of 3 e-cigarette packs based on experimental condition ( | PMC10015302 | ||
Vaping Status | Respondents were asked which statement best described their experience with e-cigarettes: “I have never heard of e-cigarettes and never tried them,” “I have heard of e-cigarettes but have never tried them,” “I have tried e-cigarettes but do not use them (anymore),” “I have tried e-cigarettes but still use them,” and “D... | PMC10015302 | ||
Smoking Status | Respondents were asked which statement best applied to their experience with cigarettes. Response options were classified into 3 categories: “never smokers,” “former smokers,” and “current smokers” (including occasional and regular smoking) (eTable 1 in | PMC10015302 | ||
Statistical Analysis | The χAll analyses were conducted in SPSS, version 28 (IBM Corp). All statistical tests were 2-sided, and | PMC10015302 | ||
Results | ASH | The ASH Youth Survey was completed by 2513 youths, of whom 2469 (1286 female youths [52.1%]; mean [SD] age, 15.0 [2.3] years) were included in the analytical sample; the ASH Adult Survey was completed by 12 248 adults, of whom 12 046 (6412 women [53.2%]; mean [SD] age, 49.9 [17.4] years) were included in the analytical... | PMC10015302 | |
Packaging Experiment: Youth Survey | Overall (across all conditions), 943 youths (38.2%) reported that people their age would be interested in trying any of the vaping products, 794 (32.2%) reported that people their age would have no interest in trying any of the products, and 732 (29.6%) reported that they did not know which of the displayed vaping prod... | PMC10015302 | ||
Adjusted Associations Between Reporting No Interest Among People Their Age in Trying Any of the Products Shown and Packaging Condition, ASH Youth Survey 2021 (N = 2469) | REGRESSION, INTERACTIONS, ASH | Abbreviations: AOR, adjusted odds ratio; ASH, Action on Smoking and Health; NA, not applicable.Analyses were adjusted for sex, age group, socioeconomic status, vaping status, and smoking status. All data are unweighted.Reference category is selecting any of the products or “Don’t know.”ABC1 indicates high socioeconomic... | PMC10015302 | |
Associations Between Reporting No Interest in Trying Any of the Products Shown and Packaging Condition, ASH Adult Survey 2021 (N = 12 046) | REGRESSION, INTERACTIONS, ASH | Abbreviations: AOR, adjusted odds ratio; ASH, Action on Smoking and Health; NA, not applicable.Analyses were adjusted for sex, age group, socioeconomic status, vaping status, and smoking status. All data are unweighted.Reference category is “Other,” including selecting any of the products and “Don’t know.”ABC1 indicate... | PMC10015302 | |
Discussion | Findings differed between youths and adults in the associations between e-cigarette packaging and interest in trying e-cigarette products. Compared with fully branded packaging, green standardized e-cigarette packaging with no brand imagery was associated with decreased interest in trying the vaping products shown amon... | PMC10015302 | ||
Limitations and Strengths | ASH | This study has some limitations. First, there were differences between the youth and adult surveys in the wording of the items assessing outcomes, as well as vaping and smoking status. The ASH Youth Survey measure asked respondents about interest among people their age; therefore, responses did not represent participan... | PMC10015302 | |
Conclusions | The findings of this survey study suggest that reducing brand imagery through standardized e-cigarette packaging is associated with decreased appeal of e-cigarette products among youths, specifically never smokers and never vapers, without reducing its appeal among adult smokers. Overall, our findings lend support for ... | PMC10015302 | ||
Background | The purpose of this study is to explore whether decreasing the number of sutures can improve the quality of life after inferior third molar extraction. | PMC10499349 | ||
Material and Methods | trismus, swelling | DRY SOCKET, TRISMUS, POSTOPERATIVE COMPLICATIONS | This study used a three-arm randomized design that included 90 individuals. Patients were randomized and divided into three groups—the airtight suture group (traditional), the buccal drainage group, and the no-suture group. Postoperative measurements, including treatment time, visual analog scale, questionnaire on pos... | PMC10499349 |
Results | postoperative pain | The buccal drainage group showed a significant decrease in postoperative pain and better speech ability than the no-suture group on the 3st day, with a mean of 1.3 and 0.7 ( | PMC10499349 | |
Introduction | postoperative pain, nerve injury, swelling, edema, teeth damage, tooth, trismus | PERICORONITIS, EDEMA, DISEASES, DENTIGEROUS CYST, IMPACTED, SECONDARY, TRISMUS | Impacted third molars are most commonly found among wisdom teeth and lead to clinical diseases, including pericoronitis, adjacent teeth damage, and dentigerous cyst. However, many patients have fears about tooth extraction due to postoperative pain, swelling, trismus, and nerve injury that severely affects the quality ... | PMC10499349 |
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