id
float64
1.55k
110k
title
stringlengths
1
256
template_id
float64
0
6
doi
stringlengths
39
49
url
stringlengths
40
92
authors
stringlengths
1
933
protocol_text
stringlengths
34
1.08M
steps_list
stringlengths
2
269k
92,584
Glucosylceramide and glucosylsphingosine analysis
4
dx.doi.org/10.17504/protocols.io.261gedk8wv47/v2
https://www.protocols.io/view/glucosylceramide-and-glucosylsphingosine-analysis-c6ngzdbw
Tae-Un Han, Carley Corado
TITLE: Glucosylceramide and glucosylsphingosine analysis AUTHORS: Tae-Un Han, Carley Corado [DESCRIPTION] This protocol was used to analysis glucosylceramide and glucosylsphingosine levels in mouse brain and liver. It was also described in previous publication (Mol Cell Neurosci. 2020 Jan:102:103451, doi: 10.1016) [S...
["[Tissue preparation] The mouse brain and liver tissues (100-300 mg) are homogenized in 2% CHAPS solution (4 mL/g wet tissue) in 2 mL Omni homogenization tubes containing 8 mm ceramic beads", "[Tissue preparation] The homogenates are processed on the Bead Ruptor 24 (Omni International, Kennesaw, GA) for two 30 second ...
null
null
null
dx.doi.org/10.17504/protocols.io.iyacfse
null
null
TITLE: No Title AUTHORS: [STEPS] ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?.
[]
104,309
Construction of individuals ddRADseq libraries for macro-algae (Kelp) V.3
0
dx.doi.org/10.17504/protocols.io.rm7vzjo68lx1/v3
https://www.protocols.io/view/construction-of-individuals-ddradseq-libraries-for-dh4v38w6
Stéphane Mauger, Komlan Avia
TITLE: Construction of individuals ddRADseq libraries for macro-algae (Kelp) V.3 AUTHORS: Stéphane Mauger, Komlan Avia [DESCRIPTION] This protocol describes a double digested restriction-site associated DNA (ddRADseq) procedure, that is a variation on the original RAD sequencing method (Davey & Blaxter 2011), which is...
["[Solutions and buffers preparations] Annealing buffer stock (10x)\nAnnealing buffer composed 100 mM Tris-HCl, pH8; 500 mM NaCl and 10 mM EDTA \n5 mL\n5 mL\n1 mL \n39 mL \n \nHomogenize and autoclave.\n\nStore at Room temperature", "[Solutions and buffers preparations] 5 M sodium chloride solution (NaCl)\n29.2 g \nDis...
77,107
EMP 18S Illumina Amplicon Protocol
1
dx.doi.org/10.17504/protocols.io.ewov1b6pgr24/v2
https://www.protocols.io/view/emp-18s-illumina-amplicon-protocol-cpitvken
Linda A. Amaral-Zettler, Markus Bauer, Donna Berg-Lyons, Jason Betley, J. Greg Caporaso, Hugh W. Ducklow, Noah Fierer, Louise Fraser, Jack A. Gilbert, Niall Gormley, James Huntley, Susan M. Huse, Janet K. Jansson, Simon N. Jarman, Rob Knight, Chris L. Lauber, Elizabeth A. McCliment, Sarah M. Owens, Geoff Smith, Luke Th...
TITLE: EMP 18S Illumina Amplicon Protocol AUTHORS: Linda A. Amaral-Zettler, Markus Bauer, Donna Berg-Lyons, Jason Betley, J. Greg Caporaso, Hugh W. Ducklow, Noah Fierer, Louise Fraser, Jack A. Gilbert, Niall Gormley, James Huntley, Susan M. Huse, Janet K. Jansson, Simon N. Jarman, Rob Knight, Chris L. Lauber, Elizabeth...
["Amplify samples in triplicate, meaning each sample will be amplified in 3 replicate 25-µL PCR reactions.", "Pool triplicate PCR reactions for each sample into a single volume (75 µL).", "Run amplicons from each sample on an agarose gel.", "Quantify amplicons with Quant-iT PicoGreen dsDNA Assay Kit (follow manufacture...
62,622
Dynathri ve CBD Gummies Canada THE MOST POPULAR CBD GUMMY BEARS IN UNITED
1
dx.doi.org/10.17504/protocols.io.x54v9ykbpg3e/v1
https://www.protocols.io/view/dynathri-ve-cbd-gummies-canada-the-most-popular-cb-b9d6r29e
Dynathrive CBD Gummies Canada
TITLE: Dynathri ve CBD Gummies Canada THE MOST POPULAR CBD GUMMY BEARS IN UNITED AUTHORS: Dynathrive CBD Gummies Canada [DESCRIPTION] Dynathrive CBD Gummies Canada Dynathrive CBD Gummies Canada - You plan to recuperate just as truly feel over and above anyone's expectations previously! However when you are encount...
["[Dynathri ve CBD Gummies Canada THE MOST POPULAR CBD GUMMY BEARS IN UNITED STATES READ HERE REVIEWS, BENEFITS, SIDE EFFECT, INGREDIENTS, DOES IT REALLY WORK? IS IT SAFE? BUY NOW GET INSTANTLY]", "[Dynathri ve CBD Gummies Canada THE MOST POPULAR CBD GUMMY BEARS IN UNITED STATES READ HERE REVIEWS, BENEFITS, SIDE EFFEC...
86,378
Generating regionally specified astrocytes
4
dx.doi.org/10.17504/protocols.io.261ged3qov47/v1
https://www.protocols.io/view/generating-regionally-specified-astrocytes-cykixuue
Tyra Fraser, Lachlan Thompson
TITLE: Generating regionally specified astrocytes AUTHORS: Tyra Fraser, Lachlan Thompson [DESCRIPTION] This protocol outlines the differentiation of stem cells into regionally specific ventral midbrain and cortical astrocytes. The protocol is a 4–5-month procedure and requires media changes 3 times a week. [GUIDELIN...
["[Preparation] Prepare astrocyte base media by combining;\n484.5 mL Advanced DMEM/F12\n5 mLGlutaMAX\n5 mL N2\n5 mL ANTI-ANTI\n500 µL B-27+VITA", "[Sphere formation] Disassociate D13 VMDA diff or D19 Cortex diff using Accutase for3 min to 6 min \nCollect cells as small clumps and inhibit using respective diff media + R...
55,068
Transplanting Arabidopsis 
1
dx.doi.org/10.17504/protocols.io.bzz4p78w
https://www.protocols.io/view/transplanting-arabidopsis-bzz4p78w
Meghan Burns, Lynn Doran
TITLE: Transplanting Arabidopsis  AUTHORS: Meghan Burns, Lynn Doran [DESCRIPTION] Transplanting Arabidopsis grown from seed on agar plates to soil trays. [BEFORE_START] Seedlings will be ready to transplant in approximately 10 to 14 days after planting when they've formed one to two true leaves. Do not wait too...
["Look at the Arabidopsis on the agar plate and determine which one looks the best. Typically this means it is the plant with the longest roots and greenest leaves.", "Take a pair of tweezers and place them at the base of the plant. Pull up very slowly, ensuring that all of the roots come out of the agar in one piece."...
55,541
Protocol for CUBIC Clearing and Whole Mount Imaging of Mouse Lung Lobes
1
dx.doi.org/10.17504/protocols.io.b2gvqbw6
https://www.protocols.io/view/protocol-for-cubic-clearing-and-whole-mount-imagin-b2gvqbw6
Justinn Barr, Jamie Verheyden, Xin Sun
TITLE: Protocol for CUBIC Clearing and Whole Mount Imaging of Mouse Lung Lobes AUTHORS: Justinn Barr, Jamie Verheyden, Xin Sun [DESCRIPTION] This protocol is for Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis (CUBIC) of mouse lung tissue for whole lobe imaging using Zeiss Lightshee...
["[Clearing preparations] Euthanize mice by CO2 inhalation.", "[Clearing preparations] To clear blood from the lungs perfuse transcardially the animals with 1xPBS. Gravity inflate lungs with 4% paraformaldehyde (PFA) and fix overnight at 4 °C .", "[Clearing preparations] Wash the lungs at least 3x for 10 minutes with 1...
91,850
UroMOCA and ColoMOCA implantation protocol
4
dx.doi.org/10.17504/protocols.io.rm7vzxq78gx1/v1
https://www.protocols.io/view/uromoca-and-colomoca-implantation-protocol-c5xiy7ke
Brett Hanzlicek, Margot Damsaser, Dennis Bourbeau
TITLE: UroMOCA and ColoMOCA implantation protocol AUTHORS: Brett Hanzlicek, Margot Damsaser, Dennis Bourbeau [DESCRIPTION] This protocol describes the implantation of our bladder (UroMOCA) and bowel device (ColoMOCA) in pigs. [STEPS] SECTION: Anesthesia 1. Anesthetize/prep the animal for surgery. Aseptic ...
["[Anesthesia] Anesthetize/prep the animal for surgery.\n\n Aseptic procedures by trained personnel are utilized during the surgery. All tools are sterilized prior to insertion. Drapes will be used and personnel performing surgery will wear clean surgical scrubs, sterile gowns/gloves and...
47,452
DNA extraction and quantification 
1
dx.doi.org/10.17504/protocols.io.bsj4ncqw
https://www.protocols.io/view/dna-extraction-and-quantification-bsj4ncqw
Rene Flores Clavo, Cristian Daniel Asmat Ortega, Nataly Ruiz Quinones
TITLE: DNA extraction and quantification  AUTHORS: Rene Flores Clavo, Cristian Daniel Asmat Ortega, Nataly Ruiz Quinones [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span style = "font-weight:bold;">DNA extraction and quantification</span></div></div> [STEPS] ?. Resuspend previously grown bact...
["Resuspend previously grown bacterial cells (approximately 50 mg of bacterial fresh biomass) in 400 µL de TE 1X (10mM of Tris-HCl, 1mM of EDTA pH 8,0).", "Add 1 µL of lysozyme (100mg/ml) shortly vórtex, and incubate for 1 h at 37 °C.", "Add 67,5 µL of SDS 10 % (pre-heated at 65 °C) and 2,5 µL of Proteinase K (10 mg/mL...
98,364
Traditional Fishing Knowledge and Fishing Policy Analysis
0
dx.doi.org/10.17504/protocols.io.5qpvok547l4o/v1
https://www.protocols.io/view/traditional-fishing-knowledge-and-fishing-policy-a-dca42sgw
Kai Bloom
TITLE: Traditional Fishing Knowledge and Fishing Policy Analysis AUTHORS: Kai Bloom [DESCRIPTION] Examine how traditional fishing knowledge is not being passed down to the new generations of fishermen in Mo'orea, French Polynesia, thus causing fishing policy to be simplified. Additionally, examine the effects that sim...
["[Examining The Loss of Traditional Fishing Knowledge] Identify groups of local fishermen, both with traditional knowledge and new-generation fishermen", "[Examining The Loss of Traditional Fishing Knowledge] Conduct interviews with fishermen", "[Examining The Loss of Traditional Fishing Knowledge] Transcribe and docu...
43,598
Staining of single-cell suspensions for scMEP mass cytometry analysis
4
dx.doi.org/10.17504/protocols.io.bntnmeme
https://www.protocols.io/view/staining-of-single-cell-suspensions-for-scmep-mass-bntnmeme
Felix Hartmann
TITLE: Staining of single-cell suspensions for scMEP mass cytometry analysis AUTHORS: Felix Hartmann [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">Staining of single-cell suspensions for scMEP analysis by mass cytometry (CyTOF). This protocol includes 1) surface staining for 30min at RT, 2) PFA-fi...
["[Obtain single cell suspension]\nPrepare single cell suspensions in FACS tubes as described in the following protocol:\n{\"blocks\":[{\"key\":\"d7ogq\",\"text\":\"Preparation of single cell suspensions to be analyzed for metabolic and phenotypic features by scMEP mass cytometry analysis. This protocols spans 1) optio...
32,435
Materials and Methods - Transcriptomic profiling identifies novel transcripts, isomorphs and lncRNAs in Paracoccidioides brasiliensis
null
dx.doi.org/10.17504/protocols.io.bbwtipen
null
Fabiano Menegidio, David Aciole Barbosa, Regina Costa de Oliveira, Daniela L. Jabes, Luiz R. Nunes
TITLE: Materials and Methods - Transcriptomic profiling identifies novel transcripts, isomorphs and lncRNAs in Paracoccidioides brasiliensis AUTHORS: Fabiano Menegidio, David Aciole Barbosa, Regina Costa de Oliveira, Daniela L. Jabes, Luiz R. Nunes [STEPS] ?.
[]
92,763
Baermann Funnel Extraction
1
null
https://www.protocols.io/view/baermann-funnel-extraction-c6t3zeqn
Casey A Schlenker
TITLE: Baermann Funnel Extraction AUTHORS: Casey A Schlenker [DESCRIPTION] Baermann Funnel Extraction [STEPS] SECTION: Sample Preparation 1. Sieve soil to 2mm SECTION: Sample Preparation 2. Weigh out 50 g in a weigh boat SECTION: Sample Preparation 3. Place tissue paper on top of Baermann funnel apparatus SECTION: S...
["[Sample Preparation] Sieve soil to 2mm", "[Sample Preparation] Weigh out 50 g in a weigh boat", "[Sample Preparation] Place tissue paper on top of Baermann funnel apparatus", "[Sample Preparation] Place weighed and sieved soil on top of filter paper", "[Sample Preparation] Fill Baermann funnel with DI water using a D...
25,033
Processing Single Cell Calling Card Sequencing Data
null
dx.doi.org/10.17504/protocols.io.4phgvj6
null
Arnav Moudgil, Rob Mitra
TITLE: Processing Single Cell Calling Card Sequencing Data AUTHORS: Arnav Moudgil, Rob Mitra [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>Here we present a computational pipeline for processing single cell calling card (scCC) data. These data will have been generated from single cell RNA-se...
["[Preamble]\nThe objective of this protocol is to take sequencing reads from single cell calling cards (scCC) library and process them into a CCF (calling card format; .ccf) file. A CCF file is a modified BED file (BED3+3) that concisely enumerates every transposition event in the sequenced library.CCF files typically...
75,472
Protocol for investigating neuroprotective effect of the methanol leaf extract of Mallotus oppositifolius in lipopolysaccharide neuro-inflammation-associated depression in mice.
1
dx.doi.org/10.17504/protocols.io.bp2l693kzlqe/v1
https://www.protocols.io/view/protocol-for-investigating-neuroprotective-effect-cmxqu7mw
KENNEDY KWAMI EDEM KUKUIA, Patrick Amoateng, Ferka Yaw Takyi, Kelvin Kofi Adutwum-Ofosu, Frimpong Appiah
TITLE: Protocol for investigating neuroprotective effect of the methanol leaf extract of Mallotus oppositifolius in lipopolysaccharide neuro-inflammation-associated depression in mice. AUTHORS: KENNEDY KWAMI EDEM KUKUIA, Patrick Amoateng, Ferka Yaw Takyi, Kelvin Kofi Adutwum-Ofosu, Frimpong Appiah [DESCRIPTION] Despit...
["[COLLECTION OF MALLOTUS OPPOSITIFOLIUS LEAVES] Mallotus oppositifolius plant is common shrub. However, for this work, we collected the plant material from Centre for Plant Medicine Research, Akuapem-Mampong in the Eastern Region of Ghana. The geographical coordinates have been provided in the attached document.\nSome...
103,987
Techniques for the detection and counting of starch particles in the atmosphere
0
dx.doi.org/10.17504/protocols.io.n2bvjnzzwgk5/v1
https://www.protocols.io/view/techniques-for-the-detection-and-counting-of-starc-dhst36en
Claudio F. Pérez, Soledad Maciel Ramos Mejía, María Gassmann, Rubén F. Iacono, Mauricio C. De Marzi, Mauro Covi
TITLE: Techniques for the detection and counting of starch particles in the atmosphere AUTHORS: Claudio F. Pérez, Soledad Maciel Ramos Mejía, María Gassmann, Rubén F. Iacono, Mauricio C. De Marzi, Mauro Covi [DESCRIPTION] Suspended particles in the atmosphere (aerosols) can impact visibility, the radiation budget, arc...
["[Sampling design] Decide what type of sampling to deploy in the field (fig.1).", "[Preparation of adhesive surfaces] Prepare sticky slides spreading the adhesive mixture with a soft brush. The duration of exposure varies according to the research goals.", "[Preparation of the adhesive mixture and mounting media] Seve...
66,121
What is TruKeto?
1
dx.doi.org/10.17504/protocols.io.ewov1nbwygr2/v1
https://www.protocols.io/view/what-is-truketo-ccthswj6
orgtruketo
TITLE: What is TruKeto? AUTHORS: orgtruketo [DESCRIPTION] TruKetoDietary improvements can help a person with getting more fit quickly and train their body to rely upon fat stores for heat creation. Without a doubt, even yet, somewhat level of weight decrease regimens work. Before purchasing any fat-consuming thing, ...
[]
44,737
Modified Moore Swab Method for Microbiological Surface Waters Sampling
1
dx.doi.org/10.17504/protocols.io.bpw9mph6
https://www.protocols.io/view/modified-moore-swab-method-for-microbiological-sur-bpw9mph6
Enrique Delgado
TITLE: Modified Moore Swab Method for Microbiological Surface Waters Sampling AUTHORS: Enrique Delgado [DESCRIPTION] This protocol describes the use of modified Moore swabs to collect surface water samples for microbiological analysis. [STEPS] SECTION: Modified Moore Swab (MMS) Preparation 1. Filtration cloth. Cut ...
["[Modified Moore Swab (MMS) Preparation] Filtration cloth. Cut a 92 x 95 cm2 cheesecloth grade #90 piece and fold it horizontally. Fold it again to its half size and stretch. Fold again each of the sides until they touch each other and press it to get the cloth as flat as possible. Then, tightly roll the cheesecloth t...
98,644
SARS-CoV-2 incursion scenario in the city Fantastica v2
1
dx.doi.org/10.17504/protocols.io.kqdg326xpv25/v1
https://www.protocols.io/view/sars-cov-2-incursion-scenario-in-the-city-fantasti-dcju2unw
Benjamin Schwessinger
TITLE: SARS-CoV-2 incursion scenario in the city Fantastica v2 AUTHORS: Benjamin Schwessinger [DESCRIPTION] This protocol is part of the ANU Biosecurity mini-research project #2 "An SARS-CoV-2 incursion scenario: Genomics, phylogenetics, and incursions." This mini-research project aims to highlight the power of combin...
["Now you import all the data needed in Geneious. Track and drop the \"FantasticaSARSCoV2Sequences\" and the reference sequence \"MN908947.3\" into this in class folder.\n\n \nYou are ready for all your analysis now.", "[Section II: Generation of a multiple sequence alignment in Geneious] Now you will select all sequen...
33,091
Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus
null
dx.doi.org/10.17504/protocols.io.bcjbiuin
https://www.protocols.io/view/association-between-the-rs1544410-polymorphism-in-bcjbiuin
Nael Shaat, Anastasia Katsarou, Bushra Shahida, Rashmi B Prasad, Karl Kristensen, Tereza Planck
TITLE: Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus AUTHORS: Nael Shaat, Anastasia Katsarou, Bushra Shahida, Rashmi B Prasad, Karl Kristensen, Tereza Planck [DESCRIPTION] <div class = "text-blocks"><div class = "text-block...
[]
92,799
SCN Egg Extraction Protocol
4
dx.doi.org/10.17504/protocols.io.14egn318yl5d/v1
https://www.protocols.io/view/scn-egg-extraction-protocol-c6u7zezn
Casey A Schlenker
TITLE: SCN Egg Extraction Protocol AUTHORS: Casey A Schlenker [DESCRIPTION] OSU full SCN egg extraction protocol [STEPS] SECTION: Core Processing 1. Obtain soil cores, a small plastic bin, and anaccompanying mesh screen. Grab one Ziploc bag/container of a sample and pour it out onto the screen, on top of the bin. Car...
["[Core Processing] Obtain soil cores, a small plastic bin, and anaccompanying mesh screen. Grab one Ziploc bag/container of a sample and pour it out onto the screen, on top of the bin. Carefully break up large pieces with your fingers by rolling cores against the mesh. Do not crush pieces; break up cores gently to avo...
60,802
SJB Artificial Seawater Medium Protocol
4
dx.doi.org/10.17504/protocols.io.rm7vzy615lx1/v1
https://www.protocols.click/view/sjb-artificial-seawater-medium-protocol-b7mark2e
Shelby J Barnes, Michael Henson, Cameron Thrash
TITLE: SJB Artificial Seawater Medium Protocol AUTHORS: Shelby J Barnes, Michael Henson, Cameron Thrash [DESCRIPTION] SJB Artificial Seawater Medium Protocol SJB Artificial Seawater Medium is an amended version of JW and MWH generations of Thrash Lab artificial seawater medium. [STEPS] SECTION: Stock Preparation ...
["[Stock Preparation] Prepare the following stocks prior to medium assembly.", "[Base Salts] Using an acid-washed and autoclaved one Liter screw-top Pyrex bottle, combine basic salts in 997.4095 mL MilliQ-filtered water. (stock volumes subtracted)", "[Stock Addition] Stocks should be added in a Biosafety cabinet or hoo...
null
null
null
dx.doi.org/10.17504/protocols.io.nycdfsw
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>The use of genetically encoded ‘self-labeling tags’ with chemical fluorophore ligands enables rapid labeling of specific cells in neural tissue. To improve the chemical tagging of neurons, we synthesized and evaluated new fluorophore ligands based on Cy, Janelia Fluor, Alexa ...
[]
85,694
Analysis of immofluorescence images in ImageJ
4
dx.doi.org/10.17504/protocols.io.x54v9py4zg3e/v1
https://www.protocols.io/view/analysis-of-immofluorescence-images-in-imagej-cxw6xphe
rachel.bates
TITLE: Analysis of immofluorescence images in ImageJ AUTHORS: rachel.bates [DESCRIPTION] Analysis at a single cell level of images taken on confocal [STEPS] 1. Import image into ImageJ as a TIFF file. 2. Set scale for Image by going to Analyze --> set scale. Set distance in pixels and unit of length to appropriate v...
["Import image into ImageJ as a TIFF file.", "Set scale for Image by going to Analyze --> set scale. Set distance in pixels and unit of length to appropriate values for objective images were collected with.", "Convert image to 8 bit going to Image --> type --> 8 bit.", "Open up ROI manager using Analyser --> tools --> ...
42,683
Lab 1 Notebook
3
null
https://www.protocols.io/view/lab-1-notebook-bmw3k7gn
TITLE: Lab 1 Notebook AUTHORS: [STEPS]
[]
60,196
Purification of lysosomes using dextran-conjugated SPIONs
4
dx.doi.org/10.17504/protocols.io.bp2l61dr1vqe/v1
https://www.protocols.io/view/purification-of-lysosomes-using-dextran-conjugated-b62crgaw
William Hancock-Cerutti, Arun Kumar Tharkeshwar, Shawn M Ferguson, Pietro De Camilli
TITLE: Purification of lysosomes using dextran-conjugated SPIONs AUTHORS: William Hancock-Cerutti, Arun Kumar Tharkeshwar, Shawn M Ferguson, Pietro De Camilli [DESCRIPTION] This method describes the usage of dextran-conjugated superparamagnetic iron nanoparticles (SPIONs) to purify a lysosome fraction from culture...
[]
67,401
Testo Chews Reviews - Is It 100% Safe &amp; Effective For Building Muscle! Price
3
dx.doi.org/10.17504/protocols.io.j8nlkkxbdl5r/v1
https://www.protocols.io/view/testo-chews-reviews-is-it-100-safe-amp-effective-f-cd3hs8j6
Testo Chews
TITLE: Testo Chews Reviews - Is It 100% Safe &amp; Effective For Building Muscle! Price AUTHORS: Testo Chews [DESCRIPTION] Testo Chews Reviews [STEPS]
[]
40,862
Copy of Enzyme-linked immunosorbent assay (ELISA) for studying the presence of anti-Salmonella antibody in layer hen&#39;s egg yolks.
6
dx.doi.org/10.17504/protocols.io.bj56kq9e
https://www.protocols.io/view/copy-of-enzyme-linked-immunosorbent-assay-elisa-fo-bj56kq9e
Angel Justiz-Vaillant
TITLE: Copy of Enzyme-linked immunosorbent assay (ELISA) for studying the presence of anti-Salmonella antibody in layer hen&#39;s egg yolks. AUTHORS: Angel Justiz-Vaillant [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span style = "font-weight:bold;">Enzyme-linked immunosorbent assay (ELISA) for ...
["U-shaped bottom's ninety-six well polystyrene microplate purchased at Sigma-Aldrich, St. Louis USA was incubated with (2 µg/well) of the LPS (Sigma –Aldrich) from Salmonella Typhimurium in coating buffer (overnight at 4 ºC.)", "The microtiter plates was washed four times, with 10 % PBS-Tween-20.", "The microplate was...
60,516
Next Generation Sequencing of HIV-1 Drug Resistant Mutations
4
dx.doi.org/10.17504/protocols.io.bp2l618k5vqe/v2
https://www.protocols.io/view/next-generation-sequencing-of-hiv-1-drug-resistant-b7ccrisw
Brenna M McGruder Rawson
TITLE: Next Generation Sequencing of HIV-1 Drug Resistant Mutations AUTHORS: Brenna M McGruder Rawson [DESCRIPTION] The Florida Department of Health's Bureau of Public Health Laboratories in Jacksonville has developed a protocol for the Next Generation Sequencing (NGS) of HIV, primarily for the purpose of drug-resista...
["[RNA Extraction] RNA Extraction has been verified using the following methods", "[RNA Extraction] Qiagen QIAmp Viral RNA Mini Kit (DSP or RUO)\nhttps://www.qiagen.com/us/products/diagnostics-and-clinical-research/sample-processing/qiaamp-viral-rna-kits/", "[RNA Extraction] Thermofisher MagMAX Viral/Pathogen II (MVP I...
66,344
What Is Iron Warrior Testo Thrust Review, Side Effects, Benefits, And Price?
3
dx.doi.org/10.17504/protocols.io.kqdg3popql25/v1
https://www.protocols.io/view/what-is-iron-warrior-testo-thrust-review-side-effe-cc2gsybw
Iron Warrior Testo Thrust
TITLE: What Is Iron Warrior Testo Thrust Review, Side Effects, Benefits, And Price? AUTHORS: Iron Warrior Testo Thrust [DESCRIPTION] https://www.outlookindia.com/outlook-spotlight/iron-warrior-testo-thrust-reviews-canada-scam-alert-muscle-flow-pills-website-news-204145 [STEPS]
[]
9,583
4AA Mix
1
dx.doi.org/10.17504/protocols.io.mkpc4vn
https://www.protocols.io/view/4aa-mix-mkpc4vn
Erçağ Pinçe
TITLE: 4AA Mix AUTHORS: Erçağ Pinçe [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">4 amino acid mixture for MMH1 </div></div> [STEPS] ?. [Mix the ingredients ] 40 mL ddH2O(milliQ)620 mg L-Histidine [100mM]596 mg L-Methionine [100mM] 524 mg L-Leucine [100mM]476 mg L-Threonine [100mM]Stir for overni...
["[Mix the ingredients ]\n40 mL ddH2O(milliQ)620 mg L-Histidine [100mM]596 mg L-Methionine [100mM] 524 mg L-Leucine [100mM]476 mg L-Threonine [100mM]Stir for overnight at 37.5C. Adjust pH to 7.0.Filter sterilize and store in the cold room(+4°C)"]
87,697
Synthetic Procedure of Dimethyl 2-methoxy-4,4&#39;-biphenyldicarboxylate
6
dx.doi.org/10.17504/protocols.io.j8nlko9o5v5r/v1
https://www.protocols.io/view/synthetic-procedure-of-dimethyl-2-methoxy-4-4-39-b-czvrx656
Lisa.Stanley, Caroline Hoyt, Gregg T. Beckham
TITLE: Synthetic Procedure of Dimethyl 2-methoxy-4,4&#39;-biphenyldicarboxylate AUTHORS: Lisa.Stanley, Caroline Hoyt, Gregg T. Beckham [DESCRIPTION] Lignin represents the largest source of biomass-derived aromatic chemicals and is an ideal supplement or alternative to petroleum-based feedstocks. In connection with eff...
["[Synthetic Procedure]", "[Synthetic Procedure] Synthesis of Methyl 4-(tosyloxy)benzoate and Methyl 3-methoxy-4-(tosyloxy)benzoate. Methyl paraben (6.6194 g, 0.0435 mol), dimethylaminopyridine (0.5315 g, 0.00435 mol), and triethylamine (8.805 g, 0.0870 mol) were charged into a round-bottom flask. 60 mL of anhydrous di...
28,243
MojoSort™ Human Pan Monocyte Isolation Kit Column Protocol
null
dx.doi.org/10.17504/protocols.io.7tthnnn
null
Sam Li
TITLE: MojoSort™ Human Pan Monocyte Isolation Kit Column Protocol AUTHORS: Sam Li [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>BioLegend MojoSort™ nanobeads work in commonly used separation columns, based on our internal research as well as validation by external testing by academic labs. T...
["[Platelet Removal Protocol]\nDilute blood with 2-4 times (volume/volume) 1X PBS.", "[Platelet Removal Protocol]\nCarefully layer diluted blood over 12.5 mL of isolation medium in a 50mL tube.", "[Platelet Removal Protocol]\nCentrifuge at 400xg for 25 minutes at room temperature in a swinging-bucket rotor without the ...
97,507
CODA (part 1): setting up environment and preparing sample dataset | HuBMAP | JHU-TMC
0
dx.doi.org/10.17504/protocols.io.q26g71rpkgwz/v1
https://www.protocols.io/view/coda-part-1-setting-up-environment-and-preparing-s-dbgb2jsn
Kyu Sang Han, Pei-Hsun Wu, Joel Sunshine, Sashank Reddy, Ashley Kiemen, Denis Wirtz
TITLE: CODA (part 1): setting up environment and preparing sample dataset | HuBMAP | JHU-TMC AUTHORS: Kyu Sang Han, Pei-Hsun Wu, Joel Sunshine, Sashank Reddy, Ashley Kiemen, Denis Wirtz [DESCRIPTION] CODA workflow part 1. setting up environment and preparing dataset [STEPS] SECTION: Software requirements 1. MATLAB MA...
["[Software requirements] MATLAB MATLAB (mathworks.com)\nImage processing toolbox Image Processing Toolbox - MATLAB (mathworks.com)\nDeep learning toolbox Deep Learning Toolbox - MATLAB (mathworks.com)\nMATLAB - Resnet50 model MATLAB resnet50 (mathworks.com)", "[Software requirements] Aperio ImageScope Aperio ImageScop...
97,099
USDA LTAR Common Experiment measurement: Concentration of phosphorus, potassium, and sulfur in aboveground biomass
1
dx.doi.org/10.17504/protocols.io.14egn6bnql5d/v1
https://www.protocols.io/view/usda-ltar-common-experiment-measurement-concentrat-da3j2gkn
John L. Kovar, Ann Marie Fortuna
TITLE: USDA LTAR Common Experiment measurement: Concentration of phosphorus, potassium, and sulfur in aboveground biomass AUTHORS: John L. Kovar, Ann Marie Fortuna [DESCRIPTION] An adequate supply of plant nutrients is an important part of sustainable crop production and the overall health of a crop. Knowing the amoun...
["[Sample collection] In most cases, biomass samples will be collected at each harvest, potentially resulting in multiple samples per year.", "[Sample collection] For the common experiment, it is important to collect samples from BAU and ASP treatments when plants are at the same phenological (developmental) stage.", "...
101,288
Fresh 80% EtOH
0
dx.doi.org/10.17504/protocols.io.5qpvokkz9l4o/v1
https://www.protocols.io/view/fresh-80-etoh-de6g3hbw
Menglin WANG
TITLE: Fresh 80% EtOH AUTHORS: Menglin WANG [DESCRIPTION] To make molecular level fresh 80% ethanol. [STEPS] SECTION: 80% EtOH 1. Use a 50ml Falcon tube to mix 10 mL and 40 mL .
["[80% EtOH] Use a 50ml Falcon tube to mix 10 mL and 40 mL ."]
null
null
null
dx.doi.org/10.17504/protocols.io.dsm6c5
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] This protocol is a minor modification of that reported by Culley and Steward (2007). As the starting point for this protocol, we assume that viruses have been collected on an aluminum oxide 0.02-µm syringe-tip filter (Anotop, Whatman), but other filters capable of capturing viru...
[]
50,082
Evaluation of elasticity of the pancreas by Acoustic Radiation Force Impulse (ARFI) in acute pancreatitis patients: A systematic review and meta-analysis (protocol)
1
dx.doi.org/10.17504/protocols.io.bu6anzae
https://www.protocols.io/view/evaluation-of-elasticity-of-the-pancreas-by-acoust-bu6anzae
Kazuma Rifu, Jun Watanabe, Hideki Sasanuma, Nobuyuki Taniguchi
TITLE: Evaluation of elasticity of the pancreas by Acoustic Radiation Force Impulse (ARFI) in acute pancreatitis patients: A systematic review and meta-analysis (protocol) AUTHORS: Kazuma Rifu, Jun Watanabe, Hideki Sasanuma, Nobuyuki Taniguchi [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><div cla...
[]
null
null
null
dx.doi.org/10.17504/protocols.io.nx6dfre
null
null
TITLE: No Title AUTHORS: [STEPS] ?. ?. ?. ?.
[]
100,934
Metabarcoding PCR Protocol
0
dx.doi.org/10.17504/protocols.io.6qpvr8842lmk/v1
https://www.protocols.io/view/metabarcoding-pcr-protocol-dete3eje
Mirayana Marcelino Barros, Tiago Pereira, Alejandro De Santiago Perez, Hunter Powell, Jenna Brown
TITLE: Metabarcoding PCR Protocol AUTHORS: Mirayana Marcelino Barros, Tiago Pereira, Alejandro De Santiago Perez, Hunter Powell, Jenna Brown [DESCRIPTION] 18S Metabarcoding PCR Protocol using Invitrogen Platinum Hot Start PCR 2X Master Mix (REF 13000014) buffer. [STEPS] SECTION: Preparing the PCR tubes 1. Label PCR t...
["[Preparing the PCR tubes] Label PCR tubes and place them under a UV light for 10 min.", "[Metabarcoding PCR] Transfer 18 µL of the master mix to each PCR tube.", "[Metabarcoding PCR] Transfer 5 µL of the DNA template to each PCR tube.", "[Metabarcoding PCR] Transfer 2 µL of the Metabarcoding Primer to the assigned PC...
null
null
null
dx.doi.org/10.17504/protocols.io.rtrd6m6
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>Bloodstream infections caused by carbapenemase-producing Enterobacteriaceae (CPE) are associated with treatment failure and increased mortality. Detection of CPE from blood cultures (BC) by standard methods takes 16-72 hours, which can delay the initiation of appropriate anti...
["Draw 1-3 ml of blood culture fluid from blood culture bottles that have been flagged positive by the blood culture automate (e.g. BD Bactex FX) and that contain Gram-negative bacilli on Gram-stain.\nAdd 1 ml of blood culture fluid in a 1.5 ml reaction tube (e.g. Eppendorf).", "[Hemolysis of red blood cells] {\"blocks...
105,730
A systematic review protocol for Biometrics in healthcare: strategies for improving safety and privacy of patients’ records in sub-Saharan Countries
1
dx.doi.org/10.17504/protocols.io.261ge589wg47/v1
https://www.protocols.io/view/a-systematic-review-protocol-for-biometrics-in-hea-djha4j2e
Arnold M Hamapa, Joseph Mumba Zulu, Oswell Khondowe, Choolwe Jacobs, Mercy Wamunyima Monde, Adam Silumbwe, Lydia Hangulu
TITLE: A systematic review protocol for Biometrics in healthcare: strategies for improving safety and privacy of patients’ records in sub-Saharan Countries AUTHORS: Arnold M Hamapa, Joseph Mumba Zulu, Oswell Khondowe, Choolwe Jacobs, Mercy Wamunyima Monde, Adam Silumbwe, Lydia Hangulu [DESCRIPTION] Background: The he...
["[Methodology] The reviewers will conduct a systematic review of studies that report on strategies for implementing biometric technologies to improve the safety and privacy of patients’ records in sub-Saharan African healthcare settings and what is the impact of these strategies on healthcare outcomes within the conte...
83,438
Twenty-Three Body Measurements for the Somatomap App
1
dx.doi.org/10.17504/protocols.io.e6nvwdpr2lmk/v1
https://www.protocols.io/view/twenty-three-body-measurements-for-the-somatomap-a-cvqnw5ve
Bea Calahong, Joel P Diaz-Fong, Sameena Karsan, Jamie Feusner
TITLE: Twenty-Three Body Measurements for the Somatomap App AUTHORS: Bea Calahong, Joel P Diaz-Fong, Sameena Karsan, Jamie Feusner [DESCRIPTION] The present protocol describes the standardized measurements for the 23 body parts corresponding to the Somatomap 3D application. Somatomap 3D is a digital avatar tool which ...
["[Standard Protocol Measurement] Neck Height:\nAsk the participant to tilt their head backward and look up. Measure from the suprasternal notch to the angle of the mandible.", "[Standard Protocol Measurement] Neck Circumference:\nAsk the participant to look straight ahead of them. Measure the circumference at the 1/2-...
52,440
Gradient PCR
4
dx.doi.org/10.17504/protocols.io.bxfypjpw
https://www.protocols.io/view/gradient-pcr-bxfypjpw
Ashwinuday
TITLE: Gradient PCR AUTHORS: Ashwinuday [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">This protocol can be used to confirm genes or DNA of interest from a template using PCR. Also to amplify required amount of genes to larger amounts.</div></div> [STEPS] ?. Prepare the working stock solution of...
["Prepare the working stock solution of all the reagents required. If already prepared and stored, takeout from the refrigerator and thaw on ice.", "Prepare the following mixes each of total and 5 test samples were made for the 5 different annealing temperatures to be vaired: - Itemsnegative controltest sample (*5)ul...
45,220
Dental Calculus Field-Sampling Protocol (Sabin version)
1
dx.doi.org/10.17504/protocols.io.bqecmtaw
https://www.protocols.io/view/dental-calculus-field-sampling-protocol-sabin-vers-bqecmtaw
Susanna Sabin, James Fellows Yates
TITLE: Dental Calculus Field-Sampling Protocol (Sabin version) AUTHORS: Susanna Sabin, James Fellows Yates [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">This protocol describes how to sample dental calculus from skeletal remains for biomolecular analysis. This protocol is particularly recommended ...
["[Workstation Preparation]\nPut on two pairs of gloves.\nReplacement The outer layer will be replaced after each sampling.", "[Workstation Preparation]\nCover work surface with two layers of aluminum foil.\nReplacement The top layer of foil must be replaced after coming into contact with sampling debris. Alternatively...
14,292
Water preservation for flow cytometry
1
dx.doi.org/10.17504/protocols.io.kqdg34eo7l25/v1
https://www.protocols.click/view/water-preservation-for-flow-cytometry-r7ud9nw
Melissa B Duhaime, Rachel Cable
TITLE: Water preservation for flow cytometry AUTHORS: Melissa B Duhaime, Rachel Cable [DESCRIPTION] This method of preservation for flow cytometry was adapted from the TARA Oceans protocol for bacterial and viral flow cytometry. This version of the protocol was edited by Rachel Cable for use in EXPORTS 2018 cruises a...
["[Glutaraldehyde preparation] For 1.5 mL sample volume:\nAliquot 7.5 µL of 25% aqueous gluteraldehyde into each cryovial. Store aliquoted glutaraldehyde at 4°C until use.", "[Sample preservation] Using a sterile 10-ml syringe (see bleaching protocol in Step 2 if syringe is being reused) and the prepared filter cartrid...
22,696
Estimating the cost of HIV/AIDS and TB services at health facilities in Cambodia
null
dx.doi.org/10.17504/protocols.io.2eggbbw
null
kouland thin, Benjamin Johns
TITLE: Estimating the cost of HIV/AIDS and TB services at health facilities in Cambodia AUTHORS: kouland thin, Benjamin Johns [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">In Cambodia, HIV/AIDS and TB have historically been financed by donors, the Ministry of Health, and</div><div class = "text-bl...
[]
null
null
null
dx.doi.org/10.17504/protocols.io.eq8bdzw
null
null
TITLE: No Title AUTHORS: [GUIDELINES] SOB medium<br /> <ul> <li>1.0% Bacto-tryptone</li> <li>0.5% Bacto-yeast extract</li> <li>10.0 mM NaCl</li> <li>2.5 mM KCl</li> <li>10.0 mM MgCl<sub>2</sub></li> <li>10.0 mM MgSO<sub>4</sub></li> </ul> [STEPS] ?. ?.
[]
93,625
α-Synuclein Protein Preparation (Large scale) with Sedimentation and Thioflavin T Assays
2
dx.doi.org/10.17504/protocols.io.j8nlkop65v5r/v1
https://www.protocols.io/view/synuclein-protein-preparation-large-scale-with-se-c7nzzmf6
Michael X. Henderon, Lindsay Meyerdirk
TITLE: α-Synuclein Protein Preparation (Large scale) with Sedimentation and Thioflavin T Assays AUTHORS: Michael X. Henderon, Lindsay Meyerdirk [DESCRIPTION] This is a collection of protocols consisting α-synuclein protein preparation (large scale), thioflavin T Assay, and sedimentation assay. [STEPS]
[]
37,721
Effect of a 90 g/day low-carbohydrate diet on glycemic control, small dense low density lipoprotein, and carotid intima-media thickness in type 2 diabetic patients: an 18month randomized controlled trial protocol
1
dx.doi.org/10.17504/protocols.io.bg3zjyp6
https://www.protocols.io/view/effect-of-a-90-g-day-low-carbohydrate-diet-on-glyc-bg3zjyp6
Chin-Ying Chen, Wei Sheng Huang, Hui-Chuen Chen, Chin-Hao Chang, Long-Teng Lee, Heng-Shuen Chen, Yow-Der Kang, Wei-Chu Chie, Chyi-Feng Jan, Wei-Dean Wang, Jaw-Shiun Tsai
TITLE: Effect of a 90 g/day low-carbohydrate diet on glycemic control, small dense low density lipoprotein, and carotid intima-media thickness in type 2 diabetic patients: an 18month randomized controlled trial protocol AUTHORS: Chin-Ying Chen, Wei Sheng Huang, Hui-Chuen Chen, Chin-Hao Chang, Long-Teng Lee, Heng-Shuen ...
["Inclusion criteria Adults aged 20–80 years with type 2 DM 1. Diabetes for more than one year and had a poorly controlled HbA1c ≥ 58 mmol/mol (7.5%) in the previous three months, regardless of whether they received medications.", "Exclusion criteria 1. Pregnant or lactating women2. Impaired renal function with a seru...
null
null
null
dx.doi.org/10.17504/protocols.io.ikqccvw
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>    A method for concentrating aquatic microbes for single-cell analysis by Raman microspectroscopy. Modified from Hewes and Holm-Hansen (1983): A Method for Recovering Nanoplankton from Filters for Identification with the Microscope: The Filter-Transfer-Freeze (FTF) Techniqu...
[]
30,706
Anti-Neu5Gc Antibody Kit Protocol - ELISA
null
dx.doi.org/10.17504/protocols.io.98sh9we
null
Sam Li
TITLE: Anti-Neu5Gc Antibody Kit Protocol - ELISA AUTHORS: Sam Li [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">This protocol is essentially the same as a standard ELISA protocol, with one major exception - all animal compounds must be avoided in buffers, etc. because they contain Neu5Gc, which wil...
["Coat the 96-well ELISA plate with the target molecule in 50mM sodium carbonate-bicarbonate buffer, pH 9.5 (up to 1µg/well in 100µl carbonate buffer, in triplicate) for at least 2 hours at ambient temperature or overnight at 4°C.", "Wash the wells 3 to 5 times with PBS.", "Block wells with PBS-T (200µl/well) for 1 hou...
45,914
Effect of Multiple Biofortified Food Crops-based Meals on Micronutrient Status and Immune Function in The First 1000 Days of Life in India: Study Protocol for a Randomized Controlled Feeding Trial v2.0
3
dx.doi.org/10.17504/protocols.io.bq32myqe
https://www.protocols.io/view/effect-of-multiple-biofortified-food-crops-based-m-bq32myqe
Saurabh Mehta, Bryan Gannon, Camille E. Jones, Laura S. Hackl, Shoba A. Udipi, Varsha Thakker, Aparna Thorat, Wesley Bonam, Jere D. Haas, Julia Finkelstein
TITLE: Effect of Multiple Biofortified Food Crops-based Meals on Micronutrient Status and Immune Function in The First 1000 Days of Life in India: Study Protocol for a Randomized Controlled Feeding Trial v2.0 AUTHORS: Saurabh Mehta, Bryan Gannon, Camille E. Jones, Laura S. Hackl, Shoba A. Udipi, Varsha Thakker, Aparna ...
[]
55,580
Wastewater QC workflow in GalaxyTrakr (SSQuAWK)
1
null
https://www.protocols.io/view/wastewater-qc-workflow-in-galaxytrakr-ssquawk-b2h4qb8w
Jasmine Amirzadegan, Tunc Kayikcioglu, hugh.rand , Ruth Timme, Maria Balkey
TITLE: Wastewater QC workflow in GalaxyTrakr (SSQuAWK) AUTHORS: Jasmine Amirzadegan, Tunc Kayikcioglu, hugh.rand , Ruth Timme, Maria Balkey [DESCRIPTION] PURPOSE: Step-by-step instructions for checking sequence quality for SARS-CoV-2 wastewater samples using SSQuAWK: SARS - CoV - 2 Sequence Quality Assuranc...
["[Account set up] Create a GalaxyTrakr account here: https://account.galaxytrakr.org/Account/Register", "[Account set up] Log into your GalaxyTrakr account: https://galaxytrakr.org", "[Create a new history] Create a new history. \n\nWe recommend creating a new history for each new MiSeq Run and including the flow-cell...
33,448
SOP Appendix for Thymus
null
dx.doi.org/10.17504/protocols.io.bcwgixbw
null
Franchesca Farris
TITLE: SOP Appendix for Thymus AUTHORS: Franchesca Farris [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">This is the appendix for the Thymus SOP. </div></div> [STEPS] ?.
[]
62,981
Rachael Ray CBD Gummies - Rachael Ray CBD Gummies , Quit Smoking and 100% Pain Relief!
3
dx.doi.org/10.17504/protocols.io.81wgb6qrylpk/v1
https://www.protocols.io/view/rachael-ray-cbd-gummies-rachael-ray-cbd-gummies-qu-b9rdr526
RachaelRaycost
TITLE: Rachael Ray CBD Gummies - Rachael Ray CBD Gummies , Quit Smoking and 100% Pain Relief! AUTHORS: RachaelRaycost [DESCRIPTION] The extraction of this is finished by dependable sources that continually utilize moderate extraction measures. Your body benefits from CBD. It urges you to quiet down and get the recup...
[]
103,659
NEB #T4010 Monarch Mag Viral DNA/ RNA Extraction Kit Protocol for KingFisher Flex Automated Isolation of Viral DNA/RNA from Wastewater Samples Following Ceres Nanotrap Enrichment
0
dx.doi.org/10.17504/protocols.io.n92ld87o9v5b/v1
https://www.protocols.io/view/neb-t4010-monarch-mag-viral-dna-rna-extraction-kit-dhgj33un
Juliet Bonnevie
TITLE: NEB #T4010 Monarch Mag Viral DNA/ RNA Extraction Kit Protocol for KingFisher Flex Automated Isolation of Viral DNA/RNA from Wastewater Samples Following Ceres Nanotrap Enrichment AUTHORS: Juliet Bonnevie [DESCRIPTION] The Monarch Mag Viral DNA/RNA Extraction Kit provides a rapid and reliable magnetic bead-based...
["[Part I. Prepare the KingFisher Flex Instrument] Ensure the instrument is equipped with the KingFisher Flex 96 Deep Well head and the KingFisher Flex 96 heating block.\nIMPORTANT: The heat block must be compatible with the KingFisher 96 microplate (200 μl).", "[Part I. Prepare the KingFisher Flex Instrument] Ensure t...
48,177
MojoSort™ Human CD56 Nanobeads Column Protocol
4
null
https://www.protocols.io/view/mojosort-human-cd56-nanobeads-column-protocol-btarnid6
Ken Lau
TITLE: MojoSort™ Human CD56 Nanobeads Column Protocol AUTHORS: Ken Lau [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span style = "font-weight:bold;">MojoSort™ Human CD56 Nanobeads Column Protocol</span><span></span></div></div> [STEPS] ?. [Protocol] Prepare cells from your tissue of interest or...
["[Protocol]\nPrepare cells from your tissue of interest or blood without lysing erythrocytes.", "[Protocol]\nIn the final wash of your sample preparation, resuspend the cells in MojoSort™ Buffer by adding up to 4 mL in a 5 mL (12 x 75 mm) polypropylene tube.Note: Keep MojoSort™ Buffer on ice throughout the procedure."...
34,290
Supplemental Methods for: Sonographic B-lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis
null
dx.doi.org/10.17504/protocols.io.bdqsi5we
null
Richard J Wang, Grace Katha, Miriam Phiri, Philip Delbridge, Stephen B Gordon, Carolyn S Calfee, Laurence Huang, Jamie Rylance
TITLE: Supplemental Methods for: Sonographic B-lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis AUTHORS: Richard J Wang, Grace Katha, Miriam Phiri, Philip Delbridge, Stephen B Gordon, Carolyn S Calfee, Laurence Huang, Jamie Rylance [STEPS]
[]
41,872
FloodLAMP Inactivation Solution Prep v1.0
1
dx.doi.org/10.17504/protocols.io.bk5qky5w
https://www.protocols.io/view/floodlamp-inactivation-solution-prep-v1-0-bk5qky5w
Randy True
TITLE: FloodLAMP Inactivation Solution Prep v1.0 AUTHORS: Randy True [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">The Inactivation Solution includes TCEP, EDTA, NaOH, and water. It should be made in a chemical fume hood, as the TCEP is caustic. It is very straightforward to make if starting with ...
["[Preparation]\nAdd all TCEP to tube, break glass vial tops off, using the 1000uL pipette extract the liquid with the vial inverted", "[Preparation]\nGet amounts of TCEP, EDTA, NaOH and Ultrapure at volumes shown in chart below:", "[Preparation]\nAdd EDTA", "[Preparation]\nVortex for 10s, be sure the tube is fully clo...
94,314
SOP for TriZOL RNA and Protein Extraction
4
dx.doi.org/10.17504/protocols.io.e6nvwdyn7lmk/v1
https://www.protocols.io/view/sop-for-trizol-rna-and-protein-extraction-c8cizsue
Malu G Tansey
TITLE: SOP for TriZOL RNA and Protein Extraction AUTHORS: Malu G Tansey [DESCRIPTION] SOP for TriZOL RNA and Protein Extraction [STEPS] SECTION: Lyse Tissue 2. In hood, add (500uL or 1000uL depending on tissue size) ice cold TRIzol to 2mL tube containing sample and 1 tissue lyser bead. SECTION: Lyse Tissue 3. Place i...
["[Lyse Tissue] In hood, add (500uL or 1000uL depending on tissue size) ice cold TRIzol to 2mL tube containing sample and 1 tissue lyser bead.", "[Lyse Tissue] Place in Tissue lyser adaptors. Tubes in on “big side” of adaptors, “big side” facing out when lysing. Operate tissue lyser for 2min at 20Hz. Rearrange racks. R...
null
null
null
dx.doi.org/10.17504/protocols.io.saseaee
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>This document aims to standardize the protocol for processing of the pleural fluid and its application to QuantiFERON-TB Gold In-Tube (QFT-GIT; Cellestis Limited, Australia) system.</p> [GUIDELINES] <p><u>Goal</u>:</p> <p>This document aims to standardize the protocol for pr...
[]
62,169
Getting started with Micro-Meta App Tutorial
5
dx.doi.org/10.17504/protocols.io.36wgq7ddxvk5/v6
https://www.protocols.io/view/getting-started-with-micro-meta-app-tutorial-b8xzrxp6
Alessandro Rigano, Mathias Hammer, Joel Ryan, Claire M. Brown, David Grunwald, Caterina Strambio De Castillia
TITLE: Getting started with Micro-Meta App Tutorial AUTHORS: Alessandro Rigano, Mathias Hammer, Joel Ryan, Claire M. Brown, David Grunwald, Caterina Strambio De Castillia [DESCRIPTION] For quality, interpretation, reproducibility, and sharing value, microscopy images should be accompanied by detailed descriptions of...
["[Before the tutorial] Video introduction", "[Tutorial - 1 - Download and Install Micro-Meta App] Download Micro-Meta App\n\nFollow the instructions in this step and in Video 3 of the tutorial series to download and install the stand-alone version of the Micro-Meta App.", "[Tutorial - 1 - Download and Install Micro-Me...
23,555
Canopy Trees Survey Protocol - Forests of Southern Québec
null
dx.doi.org/10.17504/protocols.io.29bgh2n
null
Mark Vellend, Sabine St-Jean, Anna Crofts
TITLE: Canopy Trees Survey Protocol - Forests of Southern Québec AUTHORS: Mark Vellend, Sabine St-Jean, Anna Crofts [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>Here, we describe the standardized protocol used by the </span><a href="http://www.caboscience.org/" style = "text-decoration:unde...
["[Fieldwork Preparation]\nUndergo site reconnaissance. Select plot locations as follows:To fulfill the needs of locality-specific research questions, plots should span the gradients of interest (e.g., elevation and logging history), with relatively even coverage at different positions along the gradients. The aim is t...
null
null
null
dx.doi.org/10.17504/protocols.io.e8mbhu6
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>This is a protocol for transfection of H4 (Human Brain Neuroglioma) in either 10% or 100% FBS using FuGENE HD. </p> [STEPS] ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?.
[]
104,387
Generating Nuclei Segmentations for vEM datasets using Cellpose
0
dx.doi.org/10.17504/protocols.io.n2bvjnq8pgk5/v1
https://www.protocols.io/view/generating-nuclei-segmentations-for-vem-datasets-u-dh7b39in
Emma Avetissian, Alyson Petruncio, Jeff Rhoades, Aubrey Weigel, CellMap Project Team
TITLE: Generating Nuclei Segmentations for vEM datasets using Cellpose AUTHORS: Emma Avetissian, Alyson Petruncio, Jeff Rhoades, Aubrey Weigel, CellMap Project Team [DESCRIPTION] This protocol details the process of generating nucleus segmentations in FIB-SEM (Focused Ion Beam Scanning Electron Microscopy) image stac...
["[Introduction:] The purpose of this protocol is to provide comprehensive instructions on how to create nuclei segmentations in FIB-SEM datasets on OpenOrganelle.org using Cellpose. \n\nCellpose is a generalist algorithm developed by Stringer et al., (2020) to segment cellular structures. Cellpose also provides softwa...
null
null
null
dx.doi.org/10.17504/protocols.io.k7nczme
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>In recent years, fruit flies (Drosophilidae) in cherry trees in northern China have become an increasingly serious problem. In this study, we examined the species composition and dynamics of fruit flies in cherry orchards by lure traps placed  at different heights, and in thr...
[]
93,471
Protein PEGylation Protocol - Full Martini Coarse Grained v2.0 Protocol (MARTINI, INSANE, Gromacs simulations)
5
dx.doi.org/10.17504/protocols.io.eq2lyjbjqlx9/v1
https://www.protocols.io/view/protein-pegylation-protocol-full-martini-coarse-gr-c7h7zj9n
compt.biology.agutierrez, Carmen Ili Gangas
TITLE: Protein PEGylation Protocol - Full Martini Coarse Grained v2.0 Protocol (MARTINI, INSANE, Gromacs simulations) AUTHORS: compt.biology.agutierrez, Carmen Ili Gangas [DESCRIPTION] The construction of coarse-grained systems from atomistic models is a key strategy in simulating molecular-level biological systems. T...
["[INTRODUCTION] The field of improving proteins via PEGylation remains a vibrant area of research, yet a profound understanding of the interactions between polymers and proteins is still in its infancy. To shed light on these interactions and enable predictive insights, Molecular Dynamics (MD) simulations offer a powe...
19,564
Supplemental II - Assay Buffer for Hexokinase Activity and step-by-step guide for radiochemical filter paper assay for HK Activity Assay
null
dx.doi.org/10.17504/protocols.io.xckfiuw
null
Janne R. Hingst, Rie D. Bjerre, Jørgen F. P. Wojtaszewski
TITLE: Supplemental II - Assay Buffer for Hexokinase Activity and step-by-step guide for radiochemical filter paper assay for HK Activity Assay AUTHORS: Janne R. Hingst, Rie D. Bjerre, Jørgen F. P. Wojtaszewski [STEPS]
[]
70,152
Prospecting for zoonotic pathogens using targeted DNA enrichment
1
dx.doi.org/10.17504/protocols.io.5jyl8jnzrg2w/v1
https://www.protocols.io/view/prospecting-for-zoonotic-pathogens-using-targeted-cgrgtv3w
Egie Enabulele
TITLE: Prospecting for zoonotic pathogens using targeted DNA enrichment AUTHORS: Egie Enabulele [DESCRIPTION] There are over 60 zoonoses linked to small mammals, including some of the most devastating pathogens in human history. Meanwhile, millions of museum-archived tissues are available to understand natural history...
["[DNA extraction protocol (slight modification from DNeasy® Blood and Tissue Kit protocol for tissues)] Put ~ 10 mg – 20 mg of tissue in 1.5 mL microcentrifuge tubes (Note: for lysed tissue, put 180 µL of lysate in 1.5 mL microcentrifuge tubes and proceed to step iii)", "[DNA extraction protocol (slight modification f...
18,531
Lysis Aspergillus niger, extracting and purifying DNA
null
dx.doi.org/10.17504/protocols.io.wcbfasn
null
Laure Leynaud-Kieffer
TITLE: Lysis Aspergillus niger, extracting and purifying DNA AUTHORS: Laure Leynaud-Kieffer [STEPS] ?. [Grow the Biomass] -4 days before the lysis, inoculate on MMA (Minimal Media Agar - see Transformation protocol for MMA recipe) at 30oC the strain that you want to analyze. ?. [Harvest the spores] -Once enough bioma...
["[Grow the Biomass]\n-4 days before the lysis, inoculate on MMA (Minimal Media Agar - see Transformation protocol for MMA recipe) at 30oC the strain that you want to analyze.", "[Harvest the spores]\n-Once enough biomass grew on the slants, you are ready to do the lysis-Make sure that before you use the entire slant ...
80,974
Localised axotomy of human Cortical Neurons (CNs) from induced pluripotent stem cells (iPSCs)
1
dx.doi.org/10.17504/protocols.io.rm7vzbp14vx1/v1
https://www.protocols.io/view/localised-axotomy-of-human-cortical-neurons-cns-fr-ctbnwime
Quyen Do, Federico Nebuloni, Richard Wade-Martins
TITLE: Localised axotomy of human Cortical Neurons (CNs) from induced pluripotent stem cells (iPSCs) AUTHORS: Quyen Do, Federico Nebuloni, Richard Wade-Martins [DESCRIPTION] This protocol describes the process followed to perform localised axotomy of iPSC-derived human cortical axons cultured within fluid-walled dumbb...
["[Localised axotomy assay] On Day 20, remove the FC40 overlay from the Petri dish where human Cortical Neurons (CNs) were cultured inside fluid-walled dumbbells.", "[Localised axotomy assay] Gently add ~2 ml of coating-prep medium (see Materials) to destroy every fluid wall without peeling cells off the substrate.", "...
71,479
MAP-2 &amp; GFAP Staining Protocol
4
dx.doi.org/10.17504/protocols.io.q26g7y4b1gwz/v1
https://www.protocols.io/view/map-2-amp-gfap-staining-protocol-ch2xt8fn
Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni'am, Ettie Rukmigarsari
TITLE: MAP-2 &amp; GFAP Staining Protocol AUTHORS: Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni'am, Ettie Rukmigarsari [DESCRIPTION] Neurodegeneration due to neurotoxicity is one of the phenomena in temporal lobe epilepsy. Experimentally, hippocampal excitotoxicity process can occur due to kainic acid e...
["[Sample Preparation] -Tissue slices were fixed using 4% PFA for 15 minutes\n-Wash with PBS for 3 times (5 minutes each)\n-Remove PBS and add 0,1% Triton X-100 for 30 minutes\n-Wash with PBS for 3 times (5 minutes each)\n-Add 10% BSA for 30 minutes at room temperature", "[Assay Procedure] -Incubate with primary antibo...
11,564
Expression and Purification of TailSpike 1 (TSP1) Protein from E. coli
1
dx.doi.org/10.17504/protocols.io.pikdkcw
https://www.protocols.io/view/expression-and-purification-of-tailspike-1-tsp1-pr-pikdkcw
Harley King
TITLE: Expression and Purification of TailSpike 1 (TSP1) Protein from E. coli AUTHORS: Harley King [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">This protocoll adds greater clarity and stepwise-discriptions regarding the purification of tailspike protein 1 (TSP1). The structure of TSP1 is 4OJ5. </...
["[Prepare LB Broth and Grow Overnight Culture]\nPrepare 5-6L of LB broth in 4 liter baffled flasks. Sterilize for 20min. Cool in 37C with shaking From a plate, inoculate a single colony into 300mL LB broth with 200ul carbenicillin (50mg/ml). Grow Overnight.\nCooling LB broth in shaker at 37C with minimal shaking reduc...
null
null
null
dx.doi.org/10.17504/protocols.io.e6bbhan
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p><strong>Protocol of dinoflagellate cell transformation</strong></p> [STEPS] ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?.
[]
39,535
Homogenate of A. cervicornis
4
null
https://www.protocols.io/view/homogenate-of-a-cervicornis-biupkevn
Stephanie Rosales
TITLE: Homogenate of A. cervicornis AUTHORS: Stephanie Rosales [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>This protocol is to study disease in </span><span style = "font-style:italic;">Acropora cervicornis</span><span> by using a disease homogenate method. These methods are adapted from m...
["Collect fragments of A. cervicornis showing signs of active white-band disease. These fragments are preferably collected from the same area and with similar disease progression.", "Hold diseased fragment over Ziploc bag (** this will require two people**) and remove tissue by air brushing.Per fragment, remove ~10 cm2...
41,823
RNAPath Target Identification via Fluorescent Hybridization
4
dx.doi.org/10.17504/protocols.io.bk37kyrn
https://www.protocols.io/view/rnapath-target-identification-via-fluorescent-hybr-bk37kyrn
Devin Willis
TITLE: RNAPath Target Identification via Fluorescent Hybridization AUTHORS: Devin Willis [DESCRIPTION] <div class = "text-blocks"></div> [STEPS] ?. [Sample Preperation] Suspend RNA pellet in [TE Buffer] ?. [Hybridization] Add to the RNA suspension [Molecular Instruments COVID Probe Set] ?. [Hybridization] Place Mole...
["[Sample Preperation]\nSuspend RNA pellet in\n[TE Buffer]", "[Hybridization]\nAdd to the RNA suspension\n[Molecular Instruments COVID Probe Set]", "[Hybridization]\nPlace Molecular Instruments Alexa Flour 488 B1 HCR Amplifier in for\n90 °C", "[Hybridization]\nRemove Molecular Instruments Alexa Flour 488 B1 HCR Ampli...
108,810
S. palustris leaves sampling and RNA extraction 
0
dx.doi.org/10.17504/protocols.io.6qpvr85jzlmk/v1
https://www.protocols.io/view/s-palustris-leaves-sampling-and-rna-extraction-dnhi5b4e
Maria Stefanie Dwiyanti
TITLE: S. palustris leaves sampling and RNA extraction  AUTHORS: Maria Stefanie Dwiyanti [DESCRIPTION] This is a protocol for leaf sampling of S. palustris in natural habitats as well as RNA extraction method using CTAB+PVP buffer. The extraction will require 3 days. [BEFORE_START] 1. Confirm the SDS (Safety Data She...
["[Collecting S. palustris from field] Prepare RNAlater solution in 50 ml falcon tubes.", "[Collecting S. palustris from field] Choose young leaves without fiber. \n \nCut leaves into small pieces into the RNAlater solution. Proportion of leaves and RNAlater solution should be maximum 1:5.", "[Collecting S. palustris f...
91,119
B-5 BLOOD SHIPPING
4
dx.doi.org/10.17504/protocols.io.4r3l22bopl1y/v1
https://www.protocols.io/view/b-5-blood-shipping-c48pyzvn
REDI-NET Consortium
TITLE: B-5 BLOOD SHIPPING AUTHORS: REDI-NET Consortium [DESCRIPTION] This protocol describes blood shipping. [GUIDELINES] OBJECTIVE To outline steps for proper packaging and shipping of preserved blood samples from a REDI-NET Silver Lab to a REDI-NET Gold Lab. SUMMARY/SCOPE The overarching aim of the REDI-NET is t...
["[SAMPLE PREPARATION] Primary holding sample holding containers must be leak-proof. Samples should be preserved in appropriate preservative, if applicable (REDI-NET Blood Processing SOP B-2). Ensure that the lids are tightly closed to prevent leaking of storage media while in transi.", "[SAMPLE PREPARATION] Pack vials...
39,177
Nickel-NTA Protein Purification
4
dx.doi.org/10.17504/protocols.io.bihhkb36
https://www.protocols.io/view/nickel-nta-protein-purification-bihhkb36
Nay Chi Khin, Diep Ganguly, Suyan Yee, Kai Xun Chan
TITLE: Nickel-NTA Protein Purification AUTHORS: Nay Chi Khin, Diep Ganguly, Suyan Yee, Kai Xun Chan [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>Protocol to purify 6xHis-tagged recombinant proteins expressed in </span><span style = "font-style:italic;">E. coli</span><span> using Ni-NTA pull...
["[Prepare buffers]\nBuffer recipesResuspension buffer50 mM Tris-HCl, pH 8.02 mM EDTA1X Binding buffer 50 mM sodium phosphate buffer, pH 8.0 (ensure >1 pH units away from pI of expressed protein)500 mM sodium chloride0.5% Triton X-10010% glycerol10 mM imidazoleN.b. This should reflect the cell lysis buffer (e.g. https:...
null
null
null
dx.doi.org/10.17504/protocols.io.ng8dbzw
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>This protocol is a modification of a previously published method by Wilgenburg et al (<a href="https://www.ncbi.nlm.nih.gov/pubmed/23951090" target="_blank">PLoS One, 2013</a>) to obtain monocytes and Dendritic cells (DCs) from induced Pluripotent Stem Cells (iPSCs) lines. </...
[]
null
null
null
dx.doi.org/10.17504/protocols.io.gvtbw6n
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>This protocol describes the library preparation for Illumina sequencing. It accompanies the <em>GigaScience</em> publication:</p> <p> </p> <p>Benjamin Istace, et al. (2017) De novo assembly and population genomic survey of natural yeast isolates with the Oxford Nanopore MinIO...
[]
null
null
null
dx.doi.org/10.17504/protocols.io.hvdb626
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>Luminex Milliplex Cytokine/Chemokine 22-plex MAG manufacturer's protocol.</p> [STEPS] ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?.
[]
105,883
Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology
0
dx.doi.org/10.17504/protocols.io.n92ld8nxxv5b/v1
https://www.protocols.io/view/immunofluorescence-protocol-for-ffpe-human-post-mo-djm34k8n
Felicia Suteja, Hongyun Li, YuHong Fu
TITLE: Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology AUTHORS: Felicia Suteja, Hongyun Li, YuHong Fu [DESCRIPTION] This protocol details the method for preparing and staining human formalin-fixed, paraffin embedded post mortem brain tissue to detect al...
["[Day I - Tissue Prep] Place slides with FFPE human brain tissues on a slide rack and bake in a 60 °C oven for 60 min", "[De-paraffinize] 2. Continue using the slide rack, submerge slides in the following solution to de-paraffinize: \n a. HistoChoice: 2 x 7 min\n b. 100% ethanol: 2 x 3 min \n c. 95% eth...
null
null
null
dx.doi.org/10.17504/protocols.io.mcec2te
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>This protocol provides an efficient and standardized way to prepare samples ready for mass spec analysis.</p> [BEFORE_START] <p>Prepare solutions as described in the steps.</p> [STEPS] ?. ?. ?. ?. ?. ?. ?. ?. ?. ?. ?.
[]
21,848
n-PCR for a single sample
null
dx.doi.org/10.17504/protocols.io.zjyf4pw
null
Matias Ruggieri, Carolina Berini, Nicolas Ducasa, Miroslav Malkovsky, Paul Fisch, Mirna Biglione
TITLE: n-PCR for a single sample AUTHORS: Matias Ruggieri, Carolina Berini, Nicolas Ducasa, Miroslav Malkovsky, Paul Fisch, Mirna Biglione [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">HTLV-1 diagnosis using PCR is based on the amplification of the viral DNA sequences. This is usually conducted us...
["Equipment and MaterialsPipettes10µl presterilized filter tips20µl presterilized filter tips200µl presterilized filter tips1000µl presterilized filter tipsThermal Cycle (we used TProfessional TRIO)Electrophoresis equipment", "Reagents and ChemicalsTaq DNA Polymerase kit (1000 U), by Qiagen, Catalog #: Cat No./ID: 2012...
81,270
3. Taxon Group: Bryozoa
4
dx.doi.org/10.17504/protocols.io.x54v9d6mpg3e/v1
https://www.protocols.io/view/3-taxon-group-bryozoa-ctkwwkxe
John Bishop, Inez Januszczak
TITLE: 3. Taxon Group: Bryozoa AUTHORS: John Bishop, Inez Januszczak [DESCRIPTION] This is part of the collection "DToL Taxon-specific Standard Operating Procedures (SOPs) for Marine Metazoa", lead by the Other Metazoa Working Group. The SOP collection contains guidance on how to process the various marine Metazoa spe...
[]
77,070
Synchronization of kinetic and kinematic hand tasks during awake craniotomy
5
dx.doi.org/10.17504/protocols.io.5jyl89638v2w/v1
https://www.protocols.io/view/synchronization-of-kinetic-and-kinematic-hand-task-cphnvj5e
ltaquet, bjconway, Timothy F Boerger, Sarah C Young, stschwartz, Brian Schmit, maxkrucoff
TITLE: Synchronization of kinetic and kinematic hand tasks during awake craniotomy AUTHORS: ltaquet, bjconway, Timothy F Boerger, Sarah C Young, stschwartz, Brian Schmit, maxkrucoff [DESCRIPTION] Title: Synchronization of kinetic and kinematic hand tasks with electrocorticography and cortical stimulation during awake ...
["[Constructing Synchronization Circuit] Obtaining Circuit Parts and Devices\n\nThe TekScan and CyberGlove system devices can be procured directly from the companies. Any clinical EEG device used for seizure monitoring during an awake craniotomy and cortical mapping can be used if it has at least two parallel DC channe...
71,032
Fast scan cyclic voltammetry
4
dx.doi.org/10.17504/protocols.io.kxygx9py4g8j/v1
https://www.protocols.io/view/fast-scan-cyclic-voltammetry-chkyt4xw
Harry Xenias, Savio Chan, Loukia Parisiadou
TITLE: Fast scan cyclic voltammetry AUTHORS: Harry Xenias, Savio Chan, Loukia Parisiadou [DESCRIPTION] This protocol describes the ex vivo fast-scan cyclic voltammetry (FSCV) technique for detecting dopamine within the dorsal striatum in mice. [STEPS] SECTION: Carbon fiber electrode preparation 1. Suction a single c...
["[Carbon fiber electrode preparation] Suction a single carbon fiber (7μm diameter, Goodfellow) into a capillary tube (Sutter).", "[Carbon fiber electrode preparation] Load the carbon fiber/capillary tube into a puller (Narishinge), and under the microscope, hand-cut (scalpel blade) fiber tips 30-100μm past the capilla...
29,295
Chondrocyte isolation from human cartilage
null
dx.doi.org/10.17504/protocols.io.8uphwvn
null
Sarah Snelling
TITLE: Chondrocyte isolation from human cartilage AUTHORS: Sarah Snelling [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">A standard methodology used within our group for extracting chondrocytes from human cartilage obtained as waste tissue at the time of joint replacement. Chondrocytes obtained thr...
["[Collagenase preparation]\nMake up Collagenase solution (1mg/ml) in standard medium, allow to dissolve and sterile filter through a 0.45um followed by 0.2um syringe filter. The 0.45um filter step is essential to enable efficient filtration. Collagenase mixture can be used fresh or immediately frozen and used up to 6 ...
20,780
UC Davis - Erectile Dysfunction
null
dx.doi.org/10.17504/protocols.io.yikfucw
null
Li-Ming Jin
TITLE: UC Davis - Erectile Dysfunction AUTHORS: Li-Ming Jin [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span style = "font-weight:bold;">Summary: </span></div><div class = "text-block">Erectile function is well regulated by vasorelaxant and vasoconstrictive mechanisms, which can be perturbed by...
["Rats or mice are anesthetized with an intraperitoneal injection with 50 mg pentobarbital/kg weight.", "A midline incision was made from umbilicus to pubis.", "The penis was denuded of skin, and the prepuce circumcised. The testes and epididymides were repositioned into the abdomen after they were divided from their s...
104,749
Manual Aseptic Sort Procedure for BD FACS Aria II/III/Fusion
0
null
https://www.protocols.io/view/manual-aseptic-sort-procedure-for-bd-facs-aria-ii-diim4cc6
Jamie C Tijerina
TITLE: Manual Aseptic Sort Procedure for BD FACS Aria II/III/Fusion AUTHORS: Jamie C Tijerina [DESCRIPTION] This is an alternative to the automated aseptic sort procedure designed to decontaminate the lines of the BD FACS Aria Fusion instrument. Bypasses filters and other internal components that may be damaged by 10%...
["Perform decontamination of tank (see SOP). The preference is to use a spare 10L main tank when performing this procedure.", "Fill the tank with 4L of 10% bleach.", "Connect the air line and the sheath line directly to the tank. Do not connect the filter as it cannot withstand bleach.", "Place an already damaged nozzl...
null
null
null
dx.doi.org/10.17504/protocols.io.mqcc5sw
null
null
TITLE: No Title AUTHORS: [STEPS] ?. ?. ?.
[]
84,914
Canine Enteric Virus Detection Assays
1
dx.doi.org/10.17504/protocols.io.e6nvwd5z9lmk/v1
https://www.protocols.io/view/canine-enteric-virus-detection-assays-cw6sxhee
Come J Thieulent, Mariano Carossino, Laura Peak, Udeni B. R. Balasuriya
TITLE: Canine Enteric Virus Detection Assays AUTHORS: Come J Thieulent, Mariano Carossino, Laura Peak, Udeni B. R. Balasuriya [DESCRIPTION] The Canine Enteric Virus Detection Assays is intended as an in vitro veterinary reagent set, based on Reverse Transcription quantitative PCR (RT-qPCR), for the detection of canine...
["[Reaction Set Up] Thaw all reagents on ice.", "[Reaction Set Up] Centrifuge all reagents on a benchtop centrifuge to ensure no liquid is in cap and keep on ice", "[Reaction Set Up] Setup the Master Mix according to the following table 1:", "[PROGRAMMING THE THERMOCYCLER] Select the following fluorescence channels: AB...
21,768
ALM Window Surgery
1
dx.doi.org/10.17504/protocols.io.zhgf33w
https://www.protocols.io/view/alm-window-surgery-zhgf33w
JJ Kim
TITLE: ALM Window Surgery AUTHORS: JJ Kim [DESCRIPTION] <div class = "text-blocks"><div class = "text-block">Head Post and Cranial Window Outline</div><div class = "text-block">Janelia Research Campus</div><div class = "text-block">Svoboda Lab</div><div class = "text-block">Bryan Maclennan (December 2013)</div><div cl...
["[Animal Preparation]\nWeigh the mouse and transfer it to a new cage if needed (i.e. if it's group housed, or if its cage is dirty.)If mice do not have ear tags - denote first mouse removed as the first animal number etc.and cross out number on the original cage.If the mice have ear tags, use the animal number that co...
82,373
Bone Marrow Derived Macrophage (BMDM) differentiation and maintenance
4
dx.doi.org/10.17504/protocols.io.j8nlkw7bwl5r/v1
https://www.protocols.io/view/bone-marrow-derived-macrophage-bmdm-differentiatio-cupdwvi6
Narayana Yadavalli, Shawn M. Ferguson
TITLE: Bone Marrow Derived Macrophage (BMDM) differentiation and maintenance AUTHORS: Narayana Yadavalli, Shawn M. Ferguson [DESCRIPTION] This protocol describes the isolation of bone marrow derived macrophages. [STEPS] 1. Euthanize mice via CO2 or isoflurane inhalation and cervical dislocation. 2. Collect femurs ...
["Euthanize mice via CO2 or isoflurane inhalation and cervical dislocation.", "Collect femurs and flush cavities with 5 mL ice-cold PBS.", "Then, collect bone marrow cells by centrifugation 0.3 rcf, 5 min.", "Resuspend the resulting pellet and differentiate for 6 days in culture media containing: DMEMF12 supplemented w...
61,524
Panicle Ratio Network: A high-throughput dynamic phenotype recognition model based on ultra-high-definition unmanned aerial vehicle images for rice panicle analysis in fields
1
dx.doi.org/10.17504/protocols.io.bp2l6176rvqe/v1
https://www.protocols.io/view/panicle-ratio-network-a-high-throughput-dynamic-ph-b8bursnw
Ziyue Guo, Chenghai Yang, Wangnen Yang, Guoxing Chen, Zhao Jiang, Botao Wang, Jian Zhang
TITLE: Panicle Ratio Network: A high-throughput dynamic phenotype recognition model based on ultra-high-definition unmanned aerial vehicle images for rice panicle analysis in fields AUTHORS: Ziyue Guo, Chenghai Yang, Wangnen Yang, Guoxing Chen, Zhao Jiang, Botao Wang, Jian Zhang [DESCRIPTION] In order to increase the ...
["High-resolution images of rice at heading stage were obtained by camera equipment.", "After image collection, some plots were selected to investigate their panicle number and tillering number.", "The plot to be observed was cropped from the original image, and the corresponding plot image was annotated according to t...
null
null
null
dx.doi.org/10.17504/protocols.io.i3mcgk6
null
null
TITLE: No Title AUTHORS: [DESCRIPTION] <p>Long-read sequencing (e.g. Nanopore's MinION or PacBio) has the potential to dramatically improve genome assembly but the quality of the reads is critically dependent upon the quality of the input gDNA. <br /><br />Here I describe the extraction of high molecular weight DNA f...
[]
20,084
Making Differentiation Media for SH-SY5Y
null
dx.doi.org/10.17504/protocols.io.xuufnww
null
Kenneth Schackart
TITLE: Making Differentiation Media for SH-SY5Y AUTHORS: Kenneth Schackart [DESCRIPTION] <div class = "text-blocks"><div class = "text-block"><span>This describes how to make differentiation medium for SH-SY5Y using all-</span><span style = "font-style:italic;">trans-</span><span>retinoic acid.</span></div></div> [ST...
["[Make ATRA Stock Solution]\nIn a 15 mL centrifuge tube, add ethanol andautoclaved deionized water. This will make a 95% ethanol solution.\n14 ml\n0 ml", "[Make ATRA Stock Solution]\nWeigh out ATRA.\n5 mg\nATRA is light sensitive, so do this step with the lights off.", "[Make ATRA Stock Solution]\nTransfer of 95% EtO...