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An androgen prohormone, or proandrogen, is a prohormone (or prodrug) of an anabolic-androgenic steroid (AAS). They can be prohormones of testosterone or of synthetic AAS, for example, nandrolone (19-nortestosterone). Dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), and androstenedione may all be considered proandrogens of testosterone | https://huggingface.co/datasets/fmars/wiki_stem |
Androstanolone, or stanolone, also known as dihydrotestosterone (DHT) and sold under the brand name Andractim among others, is an androgen and anabolic steroid (AAS) medication and hormone which is used mainly in the treatment of low testosterone levels in men. It is also used to treat breast development and small penis in males. It is typically given as a gel for application to the skin, but can also be used as an ester by injection into muscle | https://huggingface.co/datasets/fmars/wiki_stem |
4-Androstenediol, also known as androst-4-ene-3β,17β-diol, is an androstenediol that is converted to testosterone. The conversion rate is about 15. 76%, almost triple that of 4-androstenedione, due to utilization of a different enzymatic pathway | https://huggingface.co/datasets/fmars/wiki_stem |
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT) | https://huggingface.co/datasets/fmars/wiki_stem |
Bendroflumethiazide, formerly bendrofluazide, trade name Aprinox, is a thiazide diuretic used to treat hypertension.
Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts | https://huggingface.co/datasets/fmars/wiki_stem |
Benfluorex, sold under the brand name Mediator, is an anorectic and hypolipidemic agent that is structurally related to fenfluramine (a substituted amphetamine). It may improve glycemic control and decrease insulin resistance in people with poorly controlled type-2 diabetes. It was on the market between 1976 and 2009, and is thought to have caused between 500 and 2,000 deaths | https://huggingface.co/datasets/fmars/wiki_stem |
Beta2-adrenergic agonists, also known as adrenergic β2 receptor agonists, are a class of drugs that act on the β2 adrenergic receptor. Like other β adrenergic agonists, they cause smooth muscle relaxation. β2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages, vasodilation in muscle and liver, relaxation of uterine muscle, and release of insulin | https://huggingface.co/datasets/fmars/wiki_stem |
Bolandiol (INN, also known as 19-nor-4-androstenediol, estr-4-ene-3β,17β-diol, or 3β-dihydronandrolone) is an anabolic-androgenic steroid (AAS) that was never marketed. However, a dipropionate ester derivative, bolandiol dipropionate, has been marketed. Bolandiol and its dipropionate ester are unique among AASs in that they reportedly also possesses estrogenic and progestogenic activity | https://huggingface.co/datasets/fmars/wiki_stem |
Bolasterone (INN, USAN) (brand names Myagen, Methosarb; former developmental code name U-19763), also known as 7α,17α-dimethyltestosterone, is a 17α-alkylated androgen/anabolic steroid (AAS) which is used in veterinary medicine. It has close structural similarity to testosterone, and like methyltestosterone has a methyl group at C17α in order to increase oral bioavailability. In addition, it is also 7α-methylated, similar to its 7β-methylated isomer calusterone | https://huggingface.co/datasets/fmars/wiki_stem |
Boldenone (developmental code name RU-18761), is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone. Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.
Side effects
Pharmacology
Pharmacodynamics
Like other AAS, boldenone is an agonist of the androgen receptor (AR) | https://huggingface.co/datasets/fmars/wiki_stem |
Boldenone undecylenate, or boldenone undecenoate, sold under the brand names Equipoise and Parenabol among others, is an androgen and anabolic steroid (AAS) medication which is used in veterinary medicine, mainly in horses. It was formerly used in humans as well. It is given by injection into muscle | https://huggingface.co/datasets/fmars/wiki_stem |
Bumetanide, sold under the brand name Bumex among others, is a medication used to treat swelling and high blood pressure. This includes swelling as a result of heart failure, liver failure, or kidney problems. It may work for swelling when other medications have not | https://huggingface.co/datasets/fmars/wiki_stem |
Buserelin, sold under the brand name Suprefact among others, is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine | https://huggingface.co/datasets/fmars/wiki_stem |
Chloromethylandrostenediol (CMA), also known as 4-chloro-17α-methyl-androst-4-ene-3β,17β-diol, is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of 4-androstenediol that was never marketed. It was first encountered in 2005 when it was introduced as a "dietary supplement" and putative prohormone under the name Promagnon by an online vendor called Peak Performance Laboratories. CMA was voluntarily discontinued by Gaspari Nutrition in late 2006, likely fearing government sanctions if it continued to sell the product | https://huggingface.co/datasets/fmars/wiki_stem |
Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive. It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day | https://huggingface.co/datasets/fmars/wiki_stem |
Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug used to treat high blood pressure, swelling (such as occurs in heart failure, liver failure, and nephrotic syndrome), diabetes insipidus, and renal tubular acidosis. Because chlortalidone is reliably effective in most patients with high blood pressure, it is considered a preferred initial treatment. It is also used to prevent calcium-based kidney stones | https://huggingface.co/datasets/fmars/wiki_stem |
CJC-1295, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS) which was developed by ConjuChem Biotechnologies. It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life. CJC-1295 markedly increases plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in both animals and humans | https://huggingface.co/datasets/fmars/wiki_stem |
Clenbuterol is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier. It is most commonly available as the hydrochloride salt, clenbuterol hydrochloride | https://huggingface.co/datasets/fmars/wiki_stem |
Corticorelin (INN, trade name Xerecept) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).
Medical uses
The corticorelin stimulation test helps to differentiate between the causes for adrenocorticotropic hormone (ACTH)-dependent hypercortisolism | https://huggingface.co/datasets/fmars/wiki_stem |
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. Some common naturally occurring steroid hormones are cortisol (C21H30O5), corticosterone (C21H30O4), cortisone (C21H28O5) and aldosterone (C21H28O5) | https://huggingface.co/datasets/fmars/wiki_stem |
Cyclofenil, sold under the brand name Sexovid among others, is a selective estrogen receptor modulator (SERM) medication which is used as a gonadotropin stimulant or ovulation inducer and in menopausal hormone therapy in women. It is mostly no longer available. The medication is taken by mouth | https://huggingface.co/datasets/fmars/wiki_stem |
Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions. It is taken by mouth. The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening | https://huggingface.co/datasets/fmars/wiki_stem |
Darbepoetin alfa (INN) is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compared to epoetin alpha and epoetin beta. It stimulates erythropoiesis (increases red blood cell levels) by the same mechanism as rHuEpo (binding and activating the Epo receptor) and is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy | https://huggingface.co/datasets/fmars/wiki_stem |
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. It may be given in the nose, by injection into a vein, by mouth, or under the tongue | https://huggingface.co/datasets/fmars/wiki_stem |
Desoxymethyltestosterone (DMT), known by the nicknames Madol and Pheraplex, is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-methylated derivative of dihydrotestosterone (DHT) which was never marketed for medical use. It was one of the first designer steroids to be marketed as a performance-enhancing drug to athletes and bodybuilders.
Desoxymethyltestosterone is sometimes abbreviated as DMT, though it should not be confused with the hallucinogen dimethyltryptamine, which is also known by the same acronym | https://huggingface.co/datasets/fmars/wiki_stem |
Dextroamphetamine is a central nervous system (CNS) stimulant and enantiomer of amphetamine that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant.
The amphetamine molecule exists as two enantiomers, levoamphetamine and dextroamphetamine | https://huggingface.co/datasets/fmars/wiki_stem |
Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone. The enzyme 5α-reductase catalyzes the formation of DHT from testosterone in certain tissues including the prostate gland, seminal vesicles, epididymides, skin, hair follicles, liver, and brain. This enzyme mediates reduction of the C4-5 double bond of testosterone | https://huggingface.co/datasets/fmars/wiki_stem |
Drostanolone, or dromostanolone, is an anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was never marketed. An androgen ester prodrug of drostanolone, drostanolone propionate, was formerly used in the treatment of breast cancer in women under brand names such as Drolban, Masteril, and Masteron. This has also been used non-medically for physique- or performance-enhancing purposes | https://huggingface.co/datasets/fmars/wiki_stem |
Drostanolone propionate, or dromostanolone propionate, sold under the brand names Drolban, Masteril, and Masteron among others, is an androgen and anabolic steroid (AAS) medication which was used to treat breast cancer in women but is now no longer marketed. It is given by injection into muscle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire | https://huggingface.co/datasets/fmars/wiki_stem |
Epinephrine, also known as adrenaline, is a medication and hormone. As a medication, it is used to treat several conditions, including anaphylaxis, cardiac arrest, asthma, and superficial bleeding. Inhaled epinephrine may be used to improve the symptoms of croup | https://huggingface.co/datasets/fmars/wiki_stem |
Epitestosterone, or isotestosterone, also known as 17α-testosterone or as androst-4-en-17α-ol-3-one, is an endogenous steroid and an epimer of the androgen sex hormone testosterone. It is a weak competitive antagonist of the androgen receptor (AR) and a potent 5α-reductase inhibitor. Structurally, epitestosterone differs from testosterone only in the configuration at the hydroxy-bearing carbon, C17 | https://huggingface.co/datasets/fmars/wiki_stem |
Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. In these situations they decrease the need for blood transfusions | https://huggingface.co/datasets/fmars/wiki_stem |
Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/mL) are constantly secreted in sufficient quantities to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemia due to chronic lung disease | https://huggingface.co/datasets/fmars/wiki_stem |
Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. A con with etacyrnic acid compared to the other loop diuretic drugs such as furosemide is that it has a significantly steep dose-response curve, which means the drug's dosing is very important as small variance in dose can cause a significant difference in the biological response.
Unlike the other loop diuretics, etacrynic acid is not a sulfonamide and thus use is not contraindicated in those with sulfa allergies | https://huggingface.co/datasets/fmars/wiki_stem |
Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, immunostimulation, and leukocytosis, and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune system. Etiocholanolone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects | https://huggingface.co/datasets/fmars/wiki_stem |
Examorelin (INN) (developmental code names EP-23905, MF-6003), also known as hexarelin, is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue which was developed by Mediolanum Farmaceutici. It is a hexapeptide with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 which was derived from GHRP-6. These GH-releasing peptides have no sequence similarity to ghrelin, but mimic ghrelin by acting as agonists at the ghrelin receptor | https://huggingface.co/datasets/fmars/wiki_stem |
Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow | https://huggingface.co/datasets/fmars/wiki_stem |
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects. These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors | https://huggingface.co/datasets/fmars/wiki_stem |
Fluoxymesterone, sold under the brand names Halotestin and Ultandren among others, is an androgen and anabolic steroid (AAS) medication which is used in the treatment of low testosterone levels in men, delayed puberty in boys, breast cancer in women, and anemia. It is taken by mouth. Side effects of fluoxymesterone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire | https://huggingface.co/datasets/fmars/wiki_stem |
Fulvestrant, sold under the brand name Faslodex among others, is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with abemaciclib or palbociclib in women with disease progression after endocrine therapy. It is given by injection into a muscle. Fulvestrant is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved | https://huggingface.co/datasets/fmars/wiki_stem |
Furosemide is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. It had many trade names including Discoid, Frusemide, Lasix and Uremide. Furosemide may also be used for the treatment of high blood pressure | https://huggingface.co/datasets/fmars/wiki_stem |
Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis. It has also been used to treat other conditions such as uterine fibroids and heavy menstrual bleeding and has been investigated as a method of birth control. Gestrinone is used alone and is not formulated in combination with other medications | https://huggingface.co/datasets/fmars/wiki_stem |
Ghrelin (; or lenomorelin, INN) is a hormone produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is often called a "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes. Ghrelin may help prepare for food intake by increasing gastric motility and stimulating the secretion of gastric acid | https://huggingface.co/datasets/fmars/wiki_stem |
Growth hormone-releasing peptide 6 (GHRP-6) (developmental code name SKF-110679), also known as growth hormone-releasing hexapeptide, is one of several synthetic met-enkephalin analogues that include unnatural D-amino acids, were developed for their growth hormone-releasing activity and are called growth hormone secretagogues. They lack opioid activity but are potent stimulators of growth hormone (GH) release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through activation of a completely different receptor | https://huggingface.co/datasets/fmars/wiki_stem |
Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family | https://huggingface.co/datasets/fmars/wiki_stem |
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids | https://huggingface.co/datasets/fmars/wiki_stem |
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing | https://huggingface.co/datasets/fmars/wiki_stem |
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. Hydrochlorothiazide is taken by mouth and may be combined with other blood pressure medications as a single pill to increase effectiveness | https://huggingface.co/datasets/fmars/wiki_stem |
Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene. It is used to treat high blood pressure and edema (swelling). Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide | https://huggingface.co/datasets/fmars/wiki_stem |
7α-Hydroxydehydroepiandrosterone (7α-hydroxy-DHEA; 7α-OH-DHEA), also known as 3β,7α-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a major metabolite of dehydroepiandrosterone (DHEA) that is formed by CYP7B1 (steroid 7α-hydroxylase) in tissues such as the prostate gland and by CYP3A4 in the liver. The major metabolic pathway of DHEA outside the liver is via 7-hydroxylation into 7α-OH-DHEA and 7β-OH-DHEA. 7α-OH-DHEA has weak estrogenic activity, selectively activating the estrogen receptor ERβ | https://huggingface.co/datasets/fmars/wiki_stem |
4-Hydroxytestosterone (4-OHT), also known as 4,17β-dihydroxyandrost-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and a derivative of testosterone that was never marketed. It was first patented by G. D | https://huggingface.co/datasets/fmars/wiki_stem |
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They are only present in parahoxozoan animals.
Discovery
The HIF transcriptional complex was discovered in 1995 by Gregg L | https://huggingface.co/datasets/fmars/wiki_stem |
Indapamide is a thiazide-like diuretic drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events | https://huggingface.co/datasets/fmars/wiki_stem |
Insulin (, from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells | https://huggingface.co/datasets/fmars/wiki_stem |
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases | https://huggingface.co/datasets/fmars/wiki_stem |
Ipamorelin (INN) (developmental code name NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue. It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1. Ipamorelin significantly increases plasma growth hormone (GH) levels in both animals and humans | https://huggingface.co/datasets/fmars/wiki_stem |
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, as part of transgender hormone therapy, for early puberty, or to perform chemical castration of violent sex offenders. It is given by injection into a muscle or under the skin. Leuprorelin is in the gonadotropin-releasing hormone (GnRH) analogue family of medications | https://huggingface.co/datasets/fmars/wiki_stem |
Ligandrol (VK5211, LGD-4033) is a novel nonsteroidal oral selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting and osteoporosis, discovered by Ligand Pharmaceuticals and under development by Viking Therapeutics. Ligandrol has been found in World Anti-Doping Agency (WADA) samples and in racehorses too. Like anabolic steroids, it can stimulate muscle growth | https://huggingface.co/datasets/fmars/wiki_stem |
Mesterolone, sold under the brand name Proviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels. It has also been used to treat male infertility, although this use is controversial. It is taken by mouth | https://huggingface.co/datasets/fmars/wiki_stem |
Metenolone, or methenolone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as metenolone acetate (brand name Primobolan, Nibal) and metenolone enanthate (brand name Primobolan Depot, Nibal Injection). Metenolone esters are used mainly in the treatment of anemia due to bone marrow failure. Metenolone acetate is taken by mouth, while metenolone enanthate is given by injection into muscle | https://huggingface.co/datasets/fmars/wiki_stem |
Metenolone acetate, or methenolone acetate, sold under the brand names Primobolan and Nibal, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. It is taken by mouth. Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available | https://huggingface.co/datasets/fmars/wiki_stem |
Methandriol (brand names Anabol, Crestabolic, Cytobolin, Diandren, Durabolic, Madiol, Mestenediol, Methabolic, Methydiol, Sterabolic, Stenediol), also known as methylandrostenediol, is an androgen and anabolic steroid (AAS) medication which was developed by Organon and is used in both oral and injectable (as methandriol dipropionate, methandriol propionate, or methandriol bisenanthoyl acetate) formulations. It is an orally active 17α-alkylated AAS and a derivative of the endogenous androgen prohormone androstenediol.
Medical uses
Methandriol has been used in the treatment of breast cancer in women | https://huggingface.co/datasets/fmars/wiki_stem |
Methandriol dipropionate (MADP), also known as methylandrostenediol dipropionate and sold under the brand names Arbolic, Durabolic, Or-Bolic, Probolik, and Protabolin among others, is a synthetic, injected anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of 5-androstenediol. It is an androgen ester – specifically, the C3,17β dipropionate ester of methandriol (17α-methyl-5-androstenediol) – and acts as a prodrug of methandriol in the body. Methandriol dipropionate is administered by intramuscular injection and, relative to methandriol, has an extended duration via this route of several days due to a depot effect afforded by its ester | https://huggingface.co/datasets/fmars/wiki_stem |
Methasterone, also known as methyldrostanolone and known by the nickname Superdrol, is a synthetic and orally active anabolic–androgenic steroid (AAS) which was never marketed for medical use. It was sold legally for 9 years as a body building supplement. Because of this lengthy time being legal it has more studies and references than most other designer steroids | https://huggingface.co/datasets/fmars/wiki_stem |
Methoxy polyethylene glycol-epoetin beta, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease. It is the first approved, chemically modified erythropoiesis-stimulating agent (ESA). It is on the World Health Organization's List of Essential Medicines | https://huggingface.co/datasets/fmars/wiki_stem |
Methylhydroxynandrolone (MOHN, MHN), also known as 4-hydroxy-17α-methyl-19-nortestosterone (HMNT), as well as 4,17β-dihydroxy-17α-methylestr-4-en-3-one, is a synthetic, orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated derivative of nandrolone (19-nortestosterone) which was never marketed. It was first described in 1964 and was studied in the treatment of breast cancer, but was not introduced for clinical use. The drug re-emerged in 2004 when it started being sold on the Internet as a "dietary supplement" | https://huggingface.co/datasets/fmars/wiki_stem |
Methylphenidate, sold under the brand names Ritalin and Concerta among others, is a central nervous system (CNS) stimulant used medically to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser extent, narcolepsy. It is a primary medication for ADHD (e. g | https://huggingface.co/datasets/fmars/wiki_stem |
Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases | https://huggingface.co/datasets/fmars/wiki_stem |
Metribolone (developmental code R1881, also known as methyltrienolone) is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical use but has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR. More precisely, metribolone is the 17α-methylated derivative of trenbolone. It was investigated briefly for the treatment of advanced breast cancer in women in the late 1960s and early 1970s, but was found to produce signs of severe hepatotoxicity at very low dosages, and its development was subsequently discontinued | https://huggingface.co/datasets/fmars/wiki_stem |
Subnautica is an action-adventure game developed and published by Unknown Worlds Entertainment. Players control a non-essential systems maintenance chief, often referred to as the janitor inside the Subnautica community, who is the only survivor of a spaceship crash on an alien planet. They are free to explore the oceanic planet | https://huggingface.co/datasets/fmars/wiki_stem |
Team Sonic Racing is a 2019 kart racing game and a spin-off from Sega's Sonic the Hedgehog series. Controlling one of 15 characters from the series' cast, players compete in races using sports cars. Gameplay is from a third-person perspective, with players performing tricks, drifting, and collecting power-ups | https://huggingface.co/datasets/fmars/wiki_stem |
Teenage Mutant Ninja Turtles: The Cowabunga Collection is a compilation of video games developed by Digital Eclipse and published by Konami. It features thirteen Teenage Mutant Ninja Turtles video games developed by Konami between 1989 and 1994. It was released for Nintendo Switch, PlayStation 4, PlayStation 5, Windows via Steam, Xbox One and Xbox Series X/S in August 2022 | https://huggingface.co/datasets/fmars/wiki_stem |
Terraria ( (listen)) is an action-adventure sandbox game developed by Re-Logic. The game was first released for Windows on May 16, 2011, and has since been ported to several other platforms. The game features exploration, crafting, building, painting, and combat with a variety of creatures in a procedurally generated 2D world | https://huggingface.co/datasets/fmars/wiki_stem |
Rose was launched at Liverpool in 1806. She made one voyage as a slave ship in the triangular trade in enslaved people. Following the abolition of the slave trade new owners sailed her to South America, to New South Wales, and then to the South Seas as a whaler | https://huggingface.co/datasets/fmars/wiki_stem |
HMS Salisbury was a 50-gun fourth rate ship of the line of the Royal Navy, built by Richard and James Herring at Baileys Hard (near Bucklers Hard) on the Beaulieu River in Hampshire, England and launched on 18 April 1698.
Salisbury was commissioned in 1699 under her first commander, Captain Richard Lestock. The following year she joined Admiral George Rooke's fleet in the Baltic, and remained with Rooke off Dunkirk in 1701 | https://huggingface.co/datasets/fmars/wiki_stem |
Sandown does not appear in Lloyd's Register. A Sandown does appear in Lloyd's Register between 1789 and 1798, but it is a different vessel from the Sandown of this article, though the two vessels are sometimes conflated.
In January 1786 Sandown, a foreign-built ship, had grounded at Sandown Bay on the back of the Isle of Wight | https://huggingface.co/datasets/fmars/wiki_stem |
HMS Shelanagig (or Sheelanagig, or other variants), was a sloop of 16-guns purchased in the West Indies in 1780 for the Royal Navy. She was under the command of James Shepherd, (or Keith Shepherd, or Commander J. K | https://huggingface.co/datasets/fmars/wiki_stem |
Human presence in space is about humanity in space, particularly about all anthropogenic presence in space and human activity in space, that is in outer space and in a broader sense also on any extraterrestrial astronomical body.
Humans have been present in space either, in the common sense, through their direct presence and activity like human spaceflight, or through mediation of their presence and activity like with uncrewed spaceflight, making "telepresence" possible. Human presence in space, particularly through mediation, can take many physical forms from space debris, uncrewed spacecraft, artificial satellites, space observatories, crewed spacecraft, art in space, to human outposts in outer space such as space stations | https://huggingface.co/datasets/fmars/wiki_stem |
Lattice confinement fusion (LCF) is a type of nuclear fusion in which deuteron-saturated metals are exposed to gamma radiation or ion beams, such as in an IEC fusor, avoiding the confined high-temperature gasses used in other methods of fusion.
History
In 2020, a team of NASA researchers seeking a new energy source for deep-space exploration missions published the first paper describing a method for triggering nuclear fusion in the space between the atoms of a metal solid, an example of screened fusion. The experiments did not produce self-sustaining reactions, and the electron source itself was energetically expensive | https://huggingface.co/datasets/fmars/wiki_stem |
Space law is the body of law governing space-related activities, encompassing both international and domestic agreements, rules, and principles. Parameters of space law include space exploration, liability for damage, weapons use, rescue efforts, environmental preservation, information sharing, new technologies, and ethics. Other fields of law, such as administrative law, intellectual property law, arms control law, insurance law, environmental law, criminal law, and commercial law, are also integrated within the space law | https://huggingface.co/datasets/fmars/wiki_stem |
A solar gravitational lens or solar gravity lens (SGL) is a theoretical method of using the Sun as a large lens with a physical effect called gravitational lensing. It is considered the best method to directly image habitable exoplanets.
The solar gravitational lens is characterized by remarkable properties: it offers brightness amplification of up to a factor of ~1011 (at 1 μm) and extreme angular resolution (~10−10 arcsec) | https://huggingface.co/datasets/fmars/wiki_stem |
Space diplomacy refers to the integration of the collaboration of the knowledge, technology, and legislation involved in science diplomacy as applied to the expanded exploration of space. As diplomatic relationships are integral to the mitigation of various health, scientific, natural or technological issues across nations, space diplomacy is a growing field in which various nations can come to a consensus on what is fair when it comes to the exploration and commercialization of space travel.
Background
Space travel is a necessary resource for people around the world, especially when considering the use of satellites in areas like research or telecommunications | https://huggingface.co/datasets/fmars/wiki_stem |
The Space Explorers is an animated film created by Fred Ladd that was later turned into a cartoon serial and spawned a sequel series, New Adventures of the Space Explorers. The film aired in 1958; the sequel series aired the following year. For accuracy, both animated feature films used a consultant from Hayden Planetarium | https://huggingface.co/datasets/fmars/wiki_stem |
The Space Systems and Control Lab (SSCL), is a laboratory based at Iowa State University (ISU) in Ames, IA. SSCL focuses on space systems and has a massive number of independent projects. Within its department, the SSCL also has an AABL Wind and Gust Tunnel, Anechoic Chamber, Icing Tunnel, Neutral Buoyancy Tank, Rotational Diamond Anvil Cell, and a Tornado Simulator | https://huggingface.co/datasets/fmars/wiki_stem |
The Translational Research Institute for Space Health (TRISH) is a virtual, applied research consortium that pursues and funds translational research and technologies to keep astronauts healthy during space exploration, with the added benefit of potential applications on Earth. TRISH is specifically focused on human health in preparation for deep space exploration efforts, including National Aeronautics and Space Administration's (NASA) Artemis missions to the Moon, and future human missions to Mars. TRISH also supports research to collect and study biometric data gathered on commercial spaceflight missions to better understand the effect of spaceflight on the human body | https://huggingface.co/datasets/fmars/wiki_stem |
The Aeronomy of Ice in the Mesosphere (AIM or Explorer 90) is a NASA satellite launched in 2007 to conduct a planned 26-month study of noctilucent clouds (NLCs). It is the ninetieth Explorer program mission and is part of the NASA-funded Small Explorer program (SMEX).
Mission
The scientific purpose of the Aeronomy of Ice in the Mesosphere (AIM) mission is focused on the study of polar mesospheric clouds (PMCs) that form about 80 km (50 mi) above the surface of Earth in summer and mostly in the polar regions of Earth | https://huggingface.co/datasets/fmars/wiki_stem |
The Combined Release and Radiation Effects Satellite (CRRES) was launched on July 25, 1990, into a geosynchronous transfer orbit (GTO) for a nominal three-year mission to investigate fields, plasmas, and energetic particles inside the Earth's magnetosphere. As part of the CRRES program, the SPACERAD (Space Radiation Effects) project, managed by Air Force Geophysics Laboratory, investigated the radiation environment of the inner and outer radiation belts and measured radiation effects on state-of-the-art microelectronics devices. CRRES carried an array experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives | https://huggingface.co/datasets/fmars/wiki_stem |
Dynamics Explorer (DE-1 and DE-2 or Explorer 62 and Explorer 63) was a NASA mission, launched on 3 August 1981, and terminated on 28 February 1991. It consisted of two unmanned satellites, DE-1 and DE-2, whose purpose was to investigate the interactions between plasmas in the magnetosphere and those in the ionosphere. The two satellites were launched together into polar coplanar orbits, which allowed them to simultaneously observe the upper and lower parts of the atmosphere | https://huggingface.co/datasets/fmars/wiki_stem |
Dynamics Explorer 1 (DE-1 or Explorer 62) was a NASA high-altitude mission, launched on 3 August 1981, and terminated on 28 February 1991. It consisted of two satellites, DE-1 and DE-2, whose purpose was to investigate the interactions between plasmas in the magnetosphere and those in the ionosphere. The two satellites were launched together into polar coplanar orbits, which allowed them to simultaneously observe the upper and lower parts of the atmosphere | https://huggingface.co/datasets/fmars/wiki_stem |
Dynamics Explorer 2 (DE-2 or Explorer 63) was a NASA low-altitude mission, launched on 3 August 1981. It consisted of two satellites, DE-1 and DE-2, whose purpose was to investigate the interactions between plasmas in the magnetosphere and those in the ionosphere. The two satellites were launched together into polar coplanar orbits, which allowed them to simultaneously observe the upper and lower parts of the atmosphere | https://huggingface.co/datasets/fmars/wiki_stem |
Explorer 9, known as S-56A before launch, was a NASA satellite which was launched in February 1961 to study the density and composition of the upper thermosphere and lower exosphere. It was a reflight of the failed Explorer S-56 mission, and consisted of a 7 kg (15 lb), 3. 66 m (12 | https://huggingface.co/datasets/fmars/wiki_stem |
Explorer 10 (also known as Explorer X or P14) was a NASA satellite that investigated Earth's magnetic field and nearby plasma. Launched on 25 March 1961, it was an early mission in the Explorer program and was the first satellite to measure the "shock wave" generated by a solar flare.
Mission
The objective was to investigate the magnetic field and plasma as the spacecraft passed through Earth's magnetosphere and into cislunar space | https://huggingface.co/datasets/fmars/wiki_stem |
Explorer 27 (or BE-C or Beacon Explorer-C, Beacon-C or S-66C) was a small NASA satellite, launched in 1965, designed to conduct scientific research in the ionosphere. It was powered by 4 solar panels. One goal of the mission was to study in detail the shape of the Earth by way of investigating variations in its
gravitational field | https://huggingface.co/datasets/fmars/wiki_stem |
FORUM (Far-infrared Outgoing Radiation Understanding and Monitoring) is an Earth observing satellite that is scheduled to launch in 2027. The FORUM mission is led by the European Space Agency (ESA) and has as its main goal the study of the Earth's radiation budget. It is expected that FORUM's measurements will be improving climate models and offer new insights into the way climate change is affecting the planet | https://huggingface.co/datasets/fmars/wiki_stem |
Global-scale Observations of the Limb and Disk (GOLD) is a heliophysics Mission of Opportunity (MOU) for NASA's Explorers program. Led by Richard Eastes at the Laboratory for Atmospheric and Space Physics, which is located at the University of Colorado Boulder, GOLD's mission is to image the boundary between Earth and space in order to answer questions about the effects of solar and atmospheric variability of Earth's space weather. GOLD was one of 11 proposals selected, of the 42 submitted, for further study in September 2011 | https://huggingface.co/datasets/fmars/wiki_stem |
Interstellar Boundary Explorer (IBEX or Explorer 91 or SMEX-10) is a NASA satellite in Earth orbit that uses energetic neutral atoms (ENAs) to image the interaction region between the Solar System and interstellar space. The mission is part of NASA's Small Explorer program and was launched with a Pegasus-XL launch vehicle on 19 October 2008. The mission is led by Dr | https://huggingface.co/datasets/fmars/wiki_stem |
Ionospheric Connection Explorer (ICON) is a satellite designed to investigate changes in the ionosphere of Earth, the dynamic region high in our atmosphere where terrestrial weather from below meets space weather from above. ICON studies the interaction between Earth's weather systems and space weather driven by the Sun, and how this interaction drives turbulence in the upper atmosphere. It is hoped that a better understanding of this dynamic will mitigate its effects on communications, GPS signals, and technology in general | https://huggingface.co/datasets/fmars/wiki_stem |
The Global Geospace Science (GGS) Polar satellite was a NASA science spacecraft designed to study the polar magnetosphere and aurorae. It was launched into orbit in February 1996, and continued operations until the program was terminated in April 2008. The spacecraft remains in orbit, though it is now inactive | https://huggingface.co/datasets/fmars/wiki_stem |
Financial innovation is the act of creating new financial instruments as well as new financial technologies, institutions, and markets. Recent financial innovations include hedge funds, private equity, weather derivatives, retail-structured products, exchange-traded funds, multi-family offices, and Islamic bonds (Sukuk). The shadow banking system has spawned an array of financial innovations including mortgage-backed securities products and collateralized debt obligations (CDOs) | https://huggingface.co/datasets/fmars/wiki_stem |
Innovation is the practical implementation of ideas that result in the introduction of new goods or services or improvement in offering goods or services. ISO TC 279 in the standard ISO 56000:2020 defines innovation as "a new or changed entity realizing or redistributing value". Others have different definitions; a common element in the definitions is a focus on newness, improvement, and spread of ideas or technologies | https://huggingface.co/datasets/fmars/wiki_stem |
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