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Der Psychologe Abraham Maslow (1908–1970) unterscheidet in seiner Bedürfnis- hierarchie zwischen physiologischen und psychologischen Bedürfnissen. Diese ordnet er in einer hierarchischen Anordnung an. Welches Bedürfnis bedient dein Produkt am ehesten? Die doppelte Entkopplung zeigt, dass wir Effizienz, Konsistenz und Suffizienz zusammen denken sollten. So kann der materiell-ökonomische Wohlstand vom Naturver- brauch gelöst werden und Lebensstile gefunden werden, die uns – unabhängig vom Naturverbrauch – eine wachsende Lebensqualität ermöglichen. Positioniere die Spielfigur wie ein Regler an die Stelle, an der du dein Produkt verorten würdest. Markiere hinterher die gewählte Position mit dem Stift. Gehe die Strategien durch und schreibe zu jeder R-Strategie einen Ansatz, auch wenn es bedeutet, das Produkt von Grund auf neu zu denken. Positioniere die Spielfigur wie einen Regler an die Stelle, an der du dein weiteres Vorgehen verorten würdest. Markiere die gewählte Position mit dem Stift. Beschreibe vier schnelle Ideen, die sich in dem Möglichkeitsraum verorten. Selbstverwirklichung Individualbedürfnisse Soziale Bedürfnisse Sicherheitsbedürfnisse Physiologische Bedürfnisse Welche Umweltwirkungen erzeugt dein Produkt im Laufe seines Lebens- wegs? Mit einer Hot Spot Analyse kann identifiziert werden, wo besonders viel oder besonders wenig Umweltwirkung entsteht. Dann geht es jetzt los mit einer schnellen Reise quer durch die Welt der Kreislaufwirtschaft. Welches Produkt gestaltest du? Dann ist das Spiel hier zu Ende Das Wesen deines Produktes/Vorhabens. Sammlung: Detailarbeit Konzeptionsarbeit angewandt analog angewandt digital spekulativ analog spekulativ digital Aufbereitung: Rohstoff: Produktion: Nutzung: Lebensqualität Naturverbrauch materiell- ökonomischer Wohlstand Reparatur: Beseitigung: Status quo deines Produktes: Grobe Idee schwebt im Raum Mitten im Prozess Redesign Produkt ist schon fertig Produkt soll auf Nachhaltigkeits- potentiale und Kreislauffähigkeit überprüft werden Mit dem Eindruck davon, wie der Lebensweg des Produktes aussieht, können wir mit der MIPS-Bewertung Material und Service in Bezug setzen. Mit Material Input pro Serviceeinheit wird der ökologische Rucksack, also die Menge an Rohmaterialien, die ein Produkt benötigt, berechnet und durch seinen Service geteilt. Keine Zeit für solche Späße Ja! Im Jahr 2015 haben die Vereinten Nationen mit der Agenda 2030 die Sustainable Development Goals (SDGs) für eine globale nachhaltige Ent- wicklung verabschiedet. Ihre Umsetzung soll die Lebensbedingungen von Menschen weltweit und den Zustand des globalen Ökosystems verbessern. Die R-Strategien sind Taktiken mit steigendem Zirkulari- tätslevel, die die Kreislaufführung von Produkten und Materialien unterstützen. Ein und dieselbe Produktart kann in der Umsetzung völlig unterschiedlich auftreten, z.B. indem es eher analog oder digital, spekulativ oder angewandt gedacht wurde. Wie sähe dein Produkt aus, wenn du es in diesem Möglichkeitsraum verortest? Bevor sich der Kreis schließt, nimm dir kurz Zeit für eine Reflexion. Wie geht es jetzt weiter? Gehst du eher in die Detailarbeit und optimierst dein Produkt, oder denkst nochmal über das große Ganze nach und feilst an der Konzeption? An welcher Stelle des Spiels würdest du gerne tiefer eintauchen? Welche Zielkonflikte siehst du? Wo würdest du jetzt anpacken? Recover Lässt sich dein Produkt sortenreiner trennen als Vergleichsprodukte? Wie sieht die Aufbereitung eines exemplarischen Materials deines Produktes aus? Welches Material lässt sich in deinem Produkt nicht stofflich recyceln? Schreibe selbst, wo du stehst. Was ist der wichtigste Rohstoff deines Produktes? Wo wird dein Produkt produziert? Thermische Verwertung – Verbrennung mit Energierückgewinnung. Recycle Repurpose Remanu- facture Refurbish Repair Reuse Reduce Rethink Refuse Recyceln – Materialien verarbeiten, um die gleiche oder eine niedrigere Qualität zu erhalten. Wiederverwendung – Verwendung ausrangierter (Te	poster
OPEN ACCESS UniGe supports green and gold Open Access through the IRIS UniGe institutional archive, the “Policy on open access to the scientific literature”, the activity of Genova University Press and the 7 transformative agreements signed by the University Library System since July 2020. OPEN CONNECTIONS transformative actions forward Open Science at Genoa University Anna Maria Pastorini on behalf of UniGe Open Science Group OPEN DATA OPENSCIENCE.UNIGE.IT GENOA WEEK OPEN SCIENCE GROUP It is the newborn project in UniGe! The Open data repository will be unveiled during next GenOA week 2021. The UniGe Open Science Group is preparing the right environment for the FAIR handling of research data and to support UniGe researchers in the data management plan. The purpose of the openscience.unige.it project is to become a vehicle for collaborative learning and so all academic actors - teachers, researchers, support staff, students and librarians - are involved. It was designed by analyzing the Open Science topics and matching them with the UniGe skills and activities. GenOA week, now in its 3. edition, is an event to support the challenges of Open Science. Organized by the UniGe Open Science Group, it gathers all the Open Science advocacy initiatives of the Ligurian scientific institutions (northwestern Italy). The UniGe Open Science Group represents the synergy between the University Library System and the Research Area staff. Created to promote Open Access, now it deals with the support, and advocacy of all the Open Science topics. CITE AS: AM Pastorini, Open connections: transformative actions forward Open Science at Genoa University, B15 Conference 2021 , doi: 10.5281/zenodo.5497421 REFERENCES - AM Pastorini, GenOA week 2020: i bibliotecari e la sfida dell’ accesso aperto, 2020 [CC-BY] - M Rognoni, AM Pastorini, Islands and bridges: academic librarians towards Open Innovation and the Internet of Things, 2019 [CC-BY]	poster
References: Conclusions: Results: Methods: Introduction: Worrying changes in adolescent e-cigarette use 2014-2019: A secondary analysis of five Irish health datasets J Hanafin, S Sunday, S Keogan, L Clancy TobaccoFree Research Institute Ireland Irish Thoracic Society ASM Virtual 3-4 Dec 2020 • E-cigarette use is increasing worldwide. Concerns about adolescent use include harms (known and unknown), nicotine addiction, and as a “gateway” drug. • Secondary analysis was carried out on five Irish health datasets, with questions on adolescent e-cigarette, all stratified random samples in school-based settings: ECIGS- TFRI 2014 (N=817), ESPAD-TFRI 2015 (N=1508), SILNE-R-TFRI 2016 (N=2051), GUI 2017 (N=6216), ESPAD-TFRI 2019 (N=3556). We report on 16 and 17 year olds. • Descriptive statistical techniques were used to estimate changes in prevalence, reasons for trying e-cigarettes, and relationship with tobacco at first use. Prevalence of ever-use increased from 23% in 2014 to 39% in 2019, representing a rapid increase, particularly since 2016. Curiosity (66%) and friends (29%) are now the two main reasons adolescents use e-cigarettes. Those saying they had never used tobacco when they first tried e- cigarettes increased from 32% in 2015 to 68% in 2019. E-cigarette use has risen rapidly among adolescents in Ireland since 2014. E-cigarettes are not used by adolescents for smoking cessation. Majority of adolescents who use e- cigarettes were not smokers when they started using e-cigarettes, pointing to a worrying new route into nicotine addiction. Current tobacco control regulations for young people should be extended to include e-cigarettes. • Electronic cigarette use among Irish youth: A cross sectional study of prevalence and associated factors. Babineau K, Taylor K, Clancy L (2015). PLoS ONE 10(5): e0126419. doi: 10.1371/journal.pone.0126419 • E-cigarettes: effective cessation tools or public health threat? Clancy L and Babineau K (2016). QJM: An International Journal of Medicine, 109(2): Funding: RCDHT Grant No. 184 Next	poster
The growth-predation risk trade-off in bivalves and fish Daniel van Denderen, Jelle Zandveld, Joost van den Heuvel Introduction Bivalves and teleost fish produce offspring of a constant size. This implies that individuals at early life stages in each group share the same prey and predators, whereas mature individuals may vary in size and ecological niche. Previous work has shown that fish growth is largely invariable of adult size, whereas bivalves show a strong increase in somatic growth with adult size. The reason for this difference between species groups is unclear. In this study, we develop a generic life- history optimization model to examine how growth variation with adult size may originate. THE UNIVERSITY Of RHODE ISLAND GRADUATE SCHOOL OF OCEANOGEAPHY pdvd@aqua.dtu.dk Adapted from Denechere et al. 2022 Hypothesis The size- and feeding-dependent mortality risk of predation varies between teleost fish and bivalves. Large bivalve species will tend to prioritize growth to reach large sizes quickly and outgrow a high predation mortality. Consumption of prey Losses Growth (g) Reproduction (1-g) pEW0.75 – kW1 M = mb + mcWms ∙ p Background mortality Size-based mortality Scalar of energy acquisition Generic life-history optimization model. Using dynamic programming, we determine which allocation pattern and feeding rate maximizes lifetime reproduction. Parameter g and p are optimized. k, mc and ms are varied. E is set to 1. pE is equal to growth coefficient A [g1/4yr-1] Method Mortality Results The exponent that describes size-based predation shifts the relation between the growth coefficient A and adult size. The “red” strategy increases investments in feeding with adult size. The “blue” strategy keeps the investments in feeding more constant with adult size. Juvenile mortality is highest for the “blue” strategy. Conclusion The results confirm the hypothesis that size- and feeding- dependent mortality risk may be the driver of variation of growth coefficient A with adult size between fish and bivalves. Contrary to expectations, large bivalve species have less opportunity to outgrow predation mortality than fish.	poster
Literature Review Laura Mercado Vocational Table 1: Description of the 4 schools selected with SAIs School Name Botijas Laura Mercado ESEVA Berwind Starting Year 2000 2012 2015 2017 Municipality Orocovis San Germán Corozal San Juan Rural/ Urban Rural Rural Rural Urban School type Non-vocational Vocational Vocational Traditional Farm acre(s) 2 32 5 1 Grade level K-8th 6th-12th 9th-12th 6th-8th Expanding Agroecology in Puerto Rico’s K-12 Public Schools: Indicators for Sustainable Continuation Carol E. Ramos-Gerena University at Buffalo, SUNY carolram@buffalo.edu • In 2017, and just a few weeks after Hurricane María hit Puerto Rico (PR), administrators and leaders of the Berwind Middle School faced the risk of being permanently closed. The school was characterized as underachieving and had high violence rates. Leaning on innovation to make a compelling case for their permanence, the school developed a school garden project. • The school garden initiative at Berwind Middle School, “Proyecto Agroecológico Urbano Intermedia Berwind (PAUIB),” provided a model for agroecological integration in other public schools in PR. • Carol Ramos was invited to support a research project involving Berwind Middle School (before Hurricane María) and asked to support parent and community participation in the school. • Through a stakeholder-driven research design process, a study was set out to assess “how do we ensure the long-term continuation of PAUIB?”. The results of this study motivated a broader assessment of the agricultural education offering in PR. • Since 1932, agricultural education (AE) in PR has been included in K-12 schools, but the number of school-based agroecological initiatives (SAIs) are limited. • SAIs exist in the schools that voluntarily integrate agroecology, since there is no legal or regulatory framework, nor institutional support from the Department of Education of PR (DEPR) to promote agroecology. Between 2017-20, a total of 103 schools (of all 812 public schools in PR) were in the AE program of the DEPR. This study found that teachers and school directors voluntarily developed SAIs in both agricultural (vocational and non-vocational) and traditional schools. There is no database available for all the schools with SAIs, therefore these results are limited to the interviewed sample. In the study sample, we observed diverse characteristics for SAIs, as shown below: • SAIs are a relatively inexpensive solution to foster the critical awareness, skills, knowledge and attitudes necessary for future generations to develop the capacity to question and transform the inequities within the colonial and capitalist food system in Puerto Rico 1,2,5,6 and to configure, in the long-term, the agricultural landscape of the country. • A critical component of SAIs program sustainability³ is the commitment, conviction, and leadership of local champions—specifically, teachers and school directors. Their vision and commitment to scale agroecology and overcome the challenges of managing both a school and a farm surpasses the lack of institutional support. Supporting their work through the 10 Factors could help them address their SAIs sustainability challenges. • Schools are highly capable of expanding agroecology horizontally through knowledge exchange⁴, but the organizational sustainability of school gardens3,8 should be addressed for agroecological up-scaling9,10,11 and long-term continuation of SAIs to occur. • SAIs comprise the management and planning of all components in the food system⁷ at the school scale. From food production, cultivation, packaging, distribution (to their home and/or school kitchen), acquisition (selling their production in school agriculture fairs or neighborhood businesses), consumption and waste management (composting organic waste). • Agroecological school planning requires a fundamentally different vision of food systems: through multi-actor cooperation, collective resource management, equitable gender roles and bot	poster
Geobites: Down-to-Earth summaries of new geoscience research for a broad audience Charles M. Shobe (cshobe@gfz-potsdam.de)1, Kristina T. Vrouwenvelder2, Margaret Moerchen3, and Matthew Giampoala3 1. GFZ German Research Centre for Geosciences, 2. University of Colorado Boulder, 3. American Geophysical Union Site visit statistics: the first month Geobites is supported by AGU. most-viewed post published Twitter promotion by AGU new post published •Visitors are primarily from the U.S. and Europe. •Views are driven almost exclusively by social media promotion. •One problem we face is that only 20% of page views are of science posts; we have a high "bounce rate" from the homepage. Geobites is seeking volunteer writers. Please visit www.geobites.org to get in touch. We currently write in English, but are looking to add Spanish as well. Write for Geobites! Follow us on Twitter @_geobites: Geobites is a new grassroots #scicomm blog where geoscientists write about new research for a broad audience. Geobites is one of a family of "bites" sites, where scientists write about new developments in their field for a non-specialist audience. Geobites has three primary purposes: 1.To keep the interested public–especially undergraduates who might be interested in science careers–up to date with new research, 2.To generate attention for new work that traditional science media outlets might miss, and 3.To allow geoscientists to improve their science writing skills, which will improve communication and trust between scientists and the general public. M A R C H 2 6 , 2 0 2 0 B Y C H A R L I E S H O B E What Caused the Flood that (Possibly)Gave Rise to an Empire? Featured image:The YellowRiver Breaches its Course by Ma Yuan,Public Domain Paper: Uraniumisotopic constraints on the nature of the prehistoricflood at the Lajia site, China Authors: Le Li, Jun Chen,David William Hedding,Yuanhe Fu,Maolin Ye,Gaojun Li A smallsand deposit might holdthe key to dating the rise of Chinaʼsfirst dynasty. Chinese legend holdsthat the leaders who worked to control a giant flood on the Yellow River (knowninChinaas the Great Flood)also foundedthe Xia Dynasty–the first centralizedstate inChinese history– about 4,000 years ago.Proving that the Great Flood actually happened would lend weight to ancient historicalaccounts of the foundingof the dynasty,but the evidence is stillup for debate. Some geologists argue that an earthquake caused the Great Flood.The story goes that the earthquake triggered landslidesthat dammed the Yellow River untilthe dam finally broke,releasing about 16cubic kilometers (four millionOlympic-sizedswimming pools) of water virtuallyallat once. Sediments thought to have been carried downriver by the outburst flood have been found infissures—cracks inthe groundcaused by the earthquake—atan ancient human settlement that the earthquake destroyed.Humanremainsfrom the site have been dated to about 3,900 years old.Proponents of the earthquake-causedGreat Flood theory say that the sediment-filledfissures linkthe earthquake and the flood,thereby givingus the birthdayof the centralizedChinese state. But some of the evidence for the theory that the earthquakeand floodare related is controversial.Opponents argue that the timingof the earthquake (andtherefore the dates on the humanremains)canʼt be directly linkedto the flood because the sands in the earthquake fissures might not be sediments from a giant flood.Instead, they say, the sand might have just washed down from nearby gullies. A new paper now argues that the sand inthe earthquake fissures can be chemically linkedto sources up the Yellow River,providinga strong linkbetween the earthquake and the Great Flood. Le Li and coauthors used a new geochemical techniqueto test whether the sand came from nearby gullies,or from upstream inthe Yellow River.They measured the ratio of two different isotopes of uranium(uranium-234to uranium-238)in the sand;this ratio decreases with the time since the sediments were broke	poster
Figure 2. Procedure for generating synthetic EGG time series. Image is adopted from the preprint (Miljković et al., 2023) and shared under the CC BY 4.0 DEED. iFFT stands for inverse Fast Fourier Transform. Research Activities in the Biosignal Measurement & Analysis Research Group Ilija Tanasković1,2, Nenad B. Popović1, Đorđe D. Nešković1,3, Smilja Stokanović1, Mijat Paunović1, Nadica Miljković1,4 1University of Belgrade – School of Electrical Engineering, Belgrade, Serbia 2Institute for Artificial Intelligence R&D, Serbia 3Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade 4Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia About BMA Research Group The Biosignal Measurement & Analysis (BMA) group is an informal research group at the University of Belgrade – School of Electrical Engineering (ETF). The group consists of four PhD students and one alumnus led by Associate Professor Nadica Miljković. Main research focus of the BMA group from ETF is in biomedical and clinical engineering, signal and image processing, as well as in application of Machine Learning (ML). Specifically, the BMA research is related to the measurement and analysis of electromyograms (EMG), electrogastrograms (EGG), electrocardiograms (ECG), impedance cardiograms (ICG), electrodermal activity (EDA), eye tracker data, and other signals in healthy subjects and in patients. This poster highlights selected research topics from the BMA group performed in cooperation with other institutions. Peak Detection and Biometric Identification Novel peak detection algorithm tailored for enhancing the extraction of information of interest in noisy biomedical signals has been developed. The algorithm can be applied on abdominal electrocardiogram (ECG) and eye tracker data (Tanasković & Miljković, 2023; Tanasković et al., 2023a). In the case of abdominal ECG, proposed approach allows fetal heart rate monitoring during the pregnancy, which is the key indicator of prenatal well-being. Furthermore, we combined our knowledge in signal processing and ML to create a biometric identification system using ECG and impedance cardiogram (ICG) data. Our research also digs into the influence of varying emotional states during the interaction with the system, paving the way for further research into human-computer interaction. Nonlinear Dynamics in Heart Rhythm Аnalysis Tools used in the analysis of nonlinear dynamic systems (such as Poincaré plots) are developed and adapted with the aim to uncover the complex mechanisms that govern heart rate variability. Integrating these techniques into routine clinical practice and wearable technology may lead to improvement of patients' monitoring and health outcomes. (Paunović et al., 2024) Figure 1. The comparative analysis of four ML models performance when emotional state of individual differs during the enrolment and evaluation phase. Random Forest (RF), Support Vector Machine (SVM), Linear Discriminant Analysis (LDA), Gaussian Naïve Bayes (GNB). The image is modification of image taken from (Tanasković et al., 2023b) and the image is distributed under Creative Commons Attribution License CC-BY. Feature Extraction and ML for Topographic Maps Currently, we are focusing on the analysis of topographic pressure maps obtained from the matrix-arranged pressure sensors to classify lying postures. The study is oriented towards a thorough examination of the most relevant features and on the most appropriate hyperparameters of machine learning algorithms for successful recognition of lying postures (supine, left lateral, and right lateral subjects' positions). (Nešković & Miljković, 2023) Figure 5. Image shows a Poincaré plot that represents the heart rate dynamics of a sample subject with normal sinus rhythm, sourced from the PhysioNet Normal Sinus Rhythm RR Interval Database. ML for Missing Data Imputation The BMA group research delves into the impact of missing data o	poster
gvv Projet pilote dans les centres de santé urbains Les changements physiques et émotionnels pendant la grossesse L’importance des consultations prénatales L’alimentation Le mode de vie sain Les signes de danger pendant la grossesse Le baby blues L’importance de se protéger du VIH Déroulement de l’accouchement L’allaitement au sein La planification familiale après l’accouchement Prendre soin des nouveau-nés et des femmes après l’accouchement Après une session de respiration et gymnastique du périnée, les sages-femmes échangent avec les futures mamans sur les pratiques qui favorisent la santé et sur le recours aux soins de routine et d’urgence. L’échange se fait sur la base d’un guide d’animation qui présente le déroulement des sessions PAN de façon simple et participative. Fianakaviana Sambatrafisa (FISA) https://fisamada.org District sanitaire et CSBU* d’Ambanja (Région de Diana) District sanitaire de Antananarivo Nord et CSBU (Région de Analamanga) CSBU: Centre de santé à base urbain Terre Innovative Healthcare https://www.terreinnovative.com/ ©Enfants du Monde e MADAGASCAR PARTENAIRES Les femmes enceintes, les femmes en post-partum et les nouveau-nés sont plus vulnérables face au dérèglement climatique : Des facteurs physiologiques/cliniques font que les femmes enceintes sont plus exposées aux infections, en particulier aux maladies à transmission vectorielle, ce qui entraîne une morbidité et une mortalité maternelles et des résultats défavorables pour le fœtus e Les nouveau-nés ont une capacité limitée de thermorégulation e L'insécurité alimentaire pendant la grossesse est un facteur de risque de morbidité sur la femme et le fœtus e Les températures élevées peuvent avoir des eeffets néfastes sur la santé maternelle, du fœtu s et du nouveau-né Cours de préparation à la naissance en réponse aux effets du dérèglement climatique à Madagascar Cours de préparation à la naissance au CSBU d’Ambanja Extrait d’une fiche du cours sur la préparation à la naissance e en malgache Aurore Raveloson , Nutsa Chikvaidze , Adhelia Tsizandry , Giovanna Stancanelli , Voahirana Rabakomahefa , Manjary Paulin Ramasy , Hasina Rasolondraibe , Cecilia Capello , Emma Vogel , Fabienne Tringa Fianakaviana Sambatrafisa (FISA), Enfants du Monde, Terre Innovative Healthcare, Ministère de la santé Publique 1 2 3 3 1 4 4 2 2 2 1 2 3 4 Encourager les femmes à adopte r un comporteme nt favorable pour l eur santé pendan t la grossesse et après l’accouch ement afin de rédu ire les e ffets du dé règlement climatiqu e sur leur santé et celle de leurs nouveau-nés Cours de préparation à la naissance pour les femmes enceintes : Plus de dix séances d’approfondissemen t sur différents thèm es de santé, qui ont l ieu après la visite prénatale. e Ces séances se déroulent en peti t groupe (5-8 femmes) Un flyer avec les informations clefs es t donné aux femmes Plus informées, les femmes : S’alimentent mieux Vont d’avantage aux consultations prénatales Accouchent dans un centre de santé Réagissent de manière adéquate en cas de signe s alarmants Prennent soin de leur bébé de manière adaptée Dès lors, les femmes sont mieux prises en charge et les risques sur la santé de la femme, du fœtus, du nouveau-né liés au dérèglement climatique sont mitigés. PROBLÈMES OBJECTIFS SOLUTIONS RÉSULTATS ©Terre innovative GROUPE D’ÉCHANGE AVEC LES SAGES-FEMMES LES SUJETS TRAITÉS LORS DU COURS DE PRÉPARATION À LA NAISSANCE Enfants du Monde https://edm.ch	poster
BACKGROUND Health care systems are aware of the importance of being responsive to citizens’ expectations and needs. There are many efforts across Europe to measure the progress of health care systems’ responsiveness. One measure that could inform on how successfully we are closing the gap between citizens’ expectations of care and the actual health care provided is that of a patient’s assessment of their consultation with a doctor. However, there are yet many shortcomings on the linkages between patients’ perception of the quality of a consultation and their experiences of care, and these may vary with patients’ characteristics. OBJECTIVE To explore determinants of patients’ overall perception of the quality of an outpatient consultation in Hungary, with special focus on health status and measures of the care experience. METHODS § Cross-sectional online survey among a representative sample (n=1000) of Hungary’s adult population. Focus on a subsample (n=732) that have had an outpatient consultation in the past 12 months. § Overall perception of the quality of the consultation was measured with a 5-item scale (very poor/poor/good/very good/excellent). For regression purposes, the bottom two categories were merged. § Respondents’ characteristics, self-reported health (very bad/bad/fair/good/very good), EQ-5D-5L (the value set for England was used), EQ VAS, and type of provider (GP/specialist/allied health professional; public/private) were recorded. § Patient-reported experience measures (PREMs) recommended by the OECD (a doctor spending enough time in consultation, providing easy to understand explanation, giving opportunity to ask questions, patient involvement in decision making, and waiting times) were applied. § Ordinal logistic regression was used to explore associations between overall perception of the quality of an outpatient consultation and PREMs, health measures and respondents’ characteristics. RESULTS § The median rating for the quality of the consultation was very good (average: 3.8, SD: 1.1). § Based on the ordinal logistic regression results (Table 1), respondents with fair or bad/very bad health were 26% and 20% less likely to rate the consultation as excellent, compared to those that have reported a very good health. § Those who have reported positive care experiences with 1) the doctor spending enough time in consultation (25%), 2) involvement in decision making (23%), 3) opportunity to ask questions (21%), and 4) provide easy to understand explanations (17%) were more likely to rate the consultation as excellent. § Waiting time at a doctor’s office was a significant predictor of poorer ratings (e.g. odds ratio = 0.4 for a waiting period between 30 – 60 minutes). Specialist consultations at private facilities were significantly more likely to receive better ratings. IMPLICATIONS Respondents’ self-reported health status and experiences of care were found to be important determinants of the overall perception of the quality of an outpatient consultation, in Hungary. Positive experiences of care with the time a doctor spends in the consultation and the extent to which patients are involved in decision making contributed most to the overall perception of the quality of the consultation. Conversely, waiting time at a doctors office had a significant negative effect on patients’ perception of the quality of the consultation. These aspects deserve priority when planning interventions to improve quality of care, within a value-based health care framework. Patients’ perception of the quality of consultations modelled by patient-reported experience and health-related quality of life measures Monday, Nov 4, 2019 Research Poster Session 1 (10:30 – 14:00) PNS397 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 765141. Innovative Training Network for Healthcare Performance Intelligence Professionals Covariate OR CI Sociodemographic Sex (1: Wo	poster
TOI-1135: Sub-Saturns are Universally Misaligned Emma Dugan, Xian-Yu Wang, Songhu Wang Indiana University, Bloomington, IN Introduction The Solar System exhibits several planets well aligned with their host star, however studies of hot and warm Jupiters (HJs and WJs) have shown that exoplanets can sometimes be misaligned. From analyses HJs and WJs, it has been shown that HJs are more likely to be misaligned than WJs.1 Studying the obliquities of sub–Saturns will provide further insights as to which properties, such as stellar temperature, planet-to-star mass ratio, and stellar age affect the alignment of stellar systems. TOI-1135 is a hot sub-Saturn orbiting a hot, young star and is an excellent candidate for probing the question of how planetary mass affects a planet’s likelihood of being misaligned. Observations Photometric observations of TOI-1135 were conducted using the Transiting Exoplanet Survey Satellite (TESS) in sectors 14, 19, 20, 26, 40, 47,53, 59, and 74.2 17 total spectroscopic measurements of TOI-1135 were collected using the High-Resolution mode (R ∼ 110, 000) of the NEID spectrograph. on the WIYN 3.5m telescope at Kitt Peak National Observatory.3 Top Figure: RM measurements and model residuals. Best-ﬁtted model is shown by red-dashed line, and uncertainty is represented by gray shadow. Left Figure: Stellar effective temperature vs projected spin-orbit misalignment for both isolated sub-Saturns and sub-Saturns in compact multi-planet systems, as well as Jupiters. Analysis To derive the sky-projected spin-orbit angle, we used allesfitter4 to perform a simultaneous global ﬁt to the Rossiter-McLaughlin (RM) measurements from the NEID spectrograph, radial velocity (RV) measurements from the CARMENES spectrograph at the Calar Alto Observatory5, and the light curves obtained from TESS. From this analysis we determine the sky-projected spin-orbit angle for TOI-1135 is λ = 67.9+18.1 °. We performed a periodogram analysis on the TESS light curves for this system with transit data masked out to derive the stellar spin velocity and constrain the spin-orbit angle along the line-of-sight.6 This analysis obtained a stellar rotation rate of 5.13土0.5 days, which resulted in an obliquity of Ѱ = 70.01+12.67°. References 1Albrecht et al. 2022 2Ricker et al. 2014 3Detailed information available at https://neid.ipac.caltech.edu/docs/NEID -DRP/ 4Günther& Daylan 2019, 2021 5Mallorquín et al. 2024 6Masuda & Winn 2020 Discussion TOI-1135 is a hot sub-Saturn which is misaligned relative to its stellar host. Since there are far fewer obliquity measurements for sub-Saturns than there are for HJs and WJs, every measurement of sub-Saturns provides valuable information regarding which factors encourage misalignment. As shown in the lower left plot, sub-Saturns exhibit misalignment across a wide range of stellar effective temperatures. This correlation with stellar temperature provides a piece of the puzzle that is vital for evidence of tidal realignment. From this obliquity measurement of TOI-1135, we ﬁnd further evidence that isolated planets are more likely to be misaligned than compact multis, as well as less massive planets are more likely to be misaligned than more massive planets, regardless of stellar temperature. -13.2 -16.5 My Website	poster
Myriophyllum aquaticum Penița apei Familia Haloragaceae, Clasa Magnoliopsida Plantă perenă acvatică care formează mase dense de tulpini maronii (rizomi) împletite în apă. Rizomii funcționează ca o structură de sprijin pentru rădăcinile adventive și asigură ﬂotabilitate pentru creșterea emergentă din timpul verii. Tulpinile și frunzele emergente se extind de la câțiva zeci de centimetri deasupra suprafeței apelor. Tulpina are 40-90 cm lungime, ﬂexibilă, cilindrică, fără perișori și de culoare verde. Frunzele submerse sunt rotunjite la vârf, iar frunzele emergente sunt glauce și cu vârf scurt apiculat. Florile sunt situate în axilele frunzelor emergente superioare; sunt unisexuate. Florile bărbă- tești la început sunt sesile, iar în anteză au pediceli de până la 4 mm lungime; petalele sunt în număr de patru, de culoare galbenă, stamine în număr de 8. Florile femeiești au patru sepale albe, patru stile cu stigmate albe, dens ﬁmbriate și un ovar piriform (Arshid et al. 2016). De obicei, înﬂorește primăvara, dar unele plante pot înﬂori și toamna. Foto credit: https://www.web.forumacvarist.ro/myriophyllum-aquaticum/ ; https://garden.org/plants/view/77877/Parrot-Feather-Myriophyllum-aquaticum/ Flori Specie de interes pentru UE	poster
In silico cholinergic pathway analysis indicates possible role for exogenous choline in modulating sensory processing in autism spectrum disorder Audrey Olson1,2, MS; Fuquan Zhang3, PhD; Hongbao Cao1,4, PhD; Ancha Baranova1, PhD; Margaret Slavin2, PhD, RDN 1Department of Bioinformatics and Computational Biology, School of Systems Biology, College of Science, George Mason University, Manassas, VA; 2Department of Nutrition and Food Studies, College of Health and Human Services, George Mason University, Fairfax VA; 3Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China; 4Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China 1. Ashburner et al. Gene ontology: tool for the unification of biology. Nat Genet. May 2000; 25(1):25-9. http://geneontology.org/ 2. The Gene Ontology Consortium. The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. Jan 2019; 47(D1):D330-D338. http://geneontology.org/ 3. Liu, S., Rao, S., Xu, Y. et al. Identifying common genome-wide risk genes for major psychiatric traits. Hum Genet 139, 185–198 (2020). https://doi- org.mutex.gmu.edu/10.1007/s00439-019-02096-4 4. Molecular Signatures Database, MSig-DB, https://www.gsea-msigdb.org/gsea/msigdb 5. Elsevier’s Pathway Studio https://www.elsevier.com/solutions/pathway-studio-biological-research 6. Oliveros, J.C. (2007-2015) Venny. An interactive tool for comparing lists with Venn's diagrams. https://bioinfogp.cnb.csic.es/tools/venny/index.html o Sensory processing dysfunction is common in ASD. o Sensory processing relies upon sensory gating – ligand-activated, ion-channel- mediated pathways built upon cholinergic signals. o Acetylcholine plays roles in sensory processing, including auditory signal pathways, as well as cognitive function, memory, and learning. o Gene set enrichment analysis was conducted to identify Gene Ontology database1,2 pathways shared between MSig-DB curated cholinergic pathway gene sets (345 genes total) and a set of 53 autism genes identified by meta-analysis of genome- wide association studies3,4. o Ontologies associated with both the autism GWAS set and the MSig-DB functional pathway sets were identified using gene ontology association analysis within Pathway Studio (Elsevier)5. The lists of ontologies assigned to each of these gene sets were trimmed at approximately the lowest 100 p-values (p <0.01), while using a shift in p-value order of magnitude as the final determinant in list cutoff. o The gene ontology lists’ respective areas of overlap were identified using Venny6. o Associated pathways and ontologies were integrated graphically, using Pathway Studio to both illustrate and model the potential influence of dietary choline deficiency sensory pathways affected in autism. o To investigate a potential role of dietary choline intake as a means for bolstering sensory processing function, through use of scientific literature analysis using natural language processing (NLP) as a means for assessing potential gene ontological overlap between autism spectrum disorder (ASD) associated genes and cholinergic signaling pathways. o Because acetylcholine has long been identified as a modulator of ion transport throughout the body, the findings highlight a potential use for adequate dietary choline intake as a means to bolster acetylcholine supply, and therefore, ion transport related functionality across sensory domains. o Future study of sensory processing associated with autism should not only include identified genetic components, but also associated sensory processing pathway components, including acetylcholine, and its exogenous precursor, dietary choline. This project was funded by a research grant from the American Egg Board / Egg Nutrition Center. OBJECTIVES BACKGROUND METHODS RESULTS CONCLUSIONS ACKNOWLEDGEMENTS REFERENCES Figure 3. Subsequent analysis was conducted within Pathway Studio	poster
●Scans should follow Library of Congress standards optimized for text and image extraction ●PDF with correct metadata and OCR quality should be provided before enhancing the annotation for a semantic publication. Contact Rainer Krug University of Zurich, Zürich, Switzerland rainer.krug@ieu.uzh.ch CC-BY - Plazi/Berlin, June 16, 2024 312848 308454 Semantic publications “Provide a way for computers to understand the structure and even the meaning of the published information, making information search and data integration more efficient” Wikipedia * All icons used in this poster are made available online for open use through an assortment of CC licenses SEMANTICALLY ENRICHED PUBLICATIONS - THE WHAT, HOW, AND HOW IT CHANGES RESEARCH D. Agosti1, R.M. Krug2, L. Bénichou3, F. Rinaldi4, P. Ruch5, R. Waterhouse6 1Plazi, Bern, Switzerland; 2University of Zurich, Department of Evolutionary Biology and Environmental Studies, Zürich, Switzerland; 3Museum National d'Histoire Naturelle, Science Press, Paris, France; 4Dalle Molle Institute for Artificial Intelligence, Lugano-Viganello, Switzerland; 5SIB Swiss Institute of Bioinformatics, SIBiLS, Carouge 6 SIB Swiss Institute of BioinformaticsEnvironmental Bioinformatics Group, Lausanne, Switzerland. How does it change research? Access to repositories including full text machine actionable articles and data allows analyses of Millions of documents at once, as seen in BiodiversityPMC and BiotXplorer. Introduction Publications are published, apart from promoting the authors career, to disseminate knowledge. In classic models, the publication consists of the text itself plus very limited metadata. Finding publications is usually done by metadata, keyword and full text searches (e.g. using OpenAlex). This produces many false positive results. Semantically (enriched) publishing adds additional context to the paper and therefore makes it easier and more accurate to find publications in a given topic, taxon, location, etc. This makes existing approaches to literature review more accurate and additional approaches possible. 190 SCICOM_15.1_637 Publications should include semantic tagging and persistent unique identifiers, allowing the creation of FAIR data for treatments, material citations, gene sequences, and other named entities of value for biodiversity research. Taxonomic concept and taxon name usages should be presented in a format that can be automatically harvested by the Catalogue of Life, GBIF or other indexers to contribute building an authoritative list of the world’s species. Printed Publication Printed Publication with Metadata Scan-Based PDF with Metadata Text-based PDF with Metadata ASCI-Standard Structured XML with Metadata ASCI-XML with Semantic Enhancements and Metadata, FAIR data ASCI-XML with Semantic Enhancements, Attributes and Metadata Legacy Publications Prospective Publications ●Should be machine readable by being published in highly structured and semantically enriched XML. How to create semantically enhanced publications? Semantic enhanced publications can be produced during the publishing process using reference schemas and vocabularies (e.g. JATS, or Darwin Core) demonstrated by Pensoft and European Journal of Taxonomy) or conversion of legacy, printed or PDF publications. Recommendations DOI: 10.5281/zenodo.11802785 DOI DOI DOI <tp:taxon-treatment> <tp:nomenclature> <tp:taxon-name> <tp:taxon-name-part taxon-name-part-type="genus" reg="Sinoluperus"> Sinoluperus</tp:taxon-name-part> <tp:taxon-name-part taxon-name-part-type="species" reg="subcostatus"> subcostatus</tp:taxon-name-part> </tp:taxon-name> </tp:nomenclature> </tp:taxon-treatment> Reference vocabulary (Taxpub) Annotation Attribute FAIRitization of data in publications Provide data in publications, such as treatments, figures, recommendations, conclusion as FAIR data. See for example publications in the Biodiversity Literature Repository. CC-BY-SA https://pt.m.wikipedia.org/wiki/Ficheiro:FAIR_data_principles.jpg	poster
ATEE Spring Conference 2024 – May 29ᵗʰ - June 1ˢᵗ, Bergamo Using Mixed reality applications for learning Math Mosè Colangelo & Sara Bagossi Università degli studi di Torino - Department of Mathematics Function Virtuality Function Virtuality is a Mixed Reality (MR) prototype designed as a dynamic learning environment , operational in both virtual and augmented reality. It has been designed to facilitate the exploration and understanding of two-variable mathemat ical functions through immersive visual representatio ns of surfaces. This tool enables users to interact di rectly with the virtual environment using hand ge stures, eliminating the need for traditional controllers. Such a prototype has been developed within the European Project TransEET - Transforming Education with Emerging Technologies. e A preview of Function Virtuality can be seen by scanning this QR code: Main design features Visualization The prototype offers a robust feature for visualizing mathematical functions, allowing users to input their ow n formulas or choose from a selection of pre-existi ng examples. It supports both parametric and explicit forms of function eequations, providing flexibility in displaying a variety o f mathematical expressions. Users can adjust parameters and domain ranges of the functions using real-time sliders and interactive dots , allowing them to observe the impact of these changes on the surfaces. Interaction Function Virtuality includes interactive print docks, where users can "print" surfaces and manipulate them within the virtual space. These manipulations include scaling, rotating, and repositioning the surfaces. e Music mode A music mode feature is integrated into the prototype, where the visualization of functions dynamically respond s to music frequencies and harmonies. Artificial Intelligence (AI) Users can generate specific surfaces within the virtual space using natural language voice commands. The artificial intelligence interprets these commands and creates the desired surfaces in real-time, simplifying the exploration of complex mathematical functions. e Research objectives Various studies on the use of Mixed Reality in Mathematics Education have demonstrated that this emerging technology can boost student engagement and interest, as well as enhance visualization and spatial abilities (Bulut & Borromeo Ferri, 2023; Lei et al., 2018).s This prototype has been developed to explore the potentialities of mixed reality for eenhancing the understanding and visualization of mathematical functions. The primary objectives include: Investigating how immersive environments can support the understanding of complex mathematical concepts; Assessing the effectiveness of interactive and dynamic visualizations in facilitating learning; Exploring the integration of AI and natural language processing to simplify user interaction with mathematical tools. References Bulut, M., & Borromeo Ferri, R. (2023). A systematic literature review on augmented reality in Mathematics Education. European Journal of Science and Mathematics Education, 556–572. https://doi.org/10.30935/scimath/13124 Colangelo, M., Ghersi, A. & Soldano, C. (2024). Function Virtuality: a prototype of a learning environment on two variable functions. Workshop presented at CIEAEM 75 Restricted Meeting 22-24 April 2024. Torino, Italy. Lei, X., Zhang, A., Wang, B., & Rau, P.-L. P. (2018). Can Virtual Reality help children learn mathematics better? The application of VR headset in children’s discipline education. In P.-L. P. Rau (Ed.), Cross-Cultural Design. Applications in Cultural Heritage, Creativit y and Social Development. Springer International Publishing. https://doi.org/10.1007/978-3-319-92252-25 Trigueros, M., Orozco-Santiago, J., & Martinez-Planell, R. (2023). Learning two-variable functions using 3D dynamic geometry. Fourth conference of the International Network for Didactic Research in University Mathematics, Leibniz Universität Hannover. Acknowledgements This stu	poster
Decision Context Approach Results Impacts Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains a challenge with several efforts underway for identifying and addressing uncertainties. To date, these approaches have been qualitative in nature. Here, an algorithmic approach to facilitate read-across using ToxCast in vitro bioactivity data in conjunction with chemical descriptor information to predict in vivo outcomes in guideline (and guideline-like) testing studies from ToxRefDB is demonstrated. The read-across prediction for a given chemical is based on the similarity weighted endpoint outcomes of its nearest neighbors, calculated using in vitro bioactivity and chemical structure descriptors, called Generalized Read-across (GenRA). GenRA is a first step in systemizing read-across by providing performance metrics and enabling the scientific confidence of a prediction to be objectively assessed. References Disruptive Innovation in Chemical Evaluation Generalized Read-across (GenRA) prediction using chemical and biological information Imran Shah,1 Jie Liu,1,2,3 Richard S. Judson,1 Russell S. Thomas,1 Grace Patlewicz1* 1NCCT/ORD/US EPA, 2ORISE, 3UALR epa.gov/research CSS BoSC Meeting 2016 Presenting author: orcid.org/0000-0003-3863-9689\| Grace Patlewicz l email: patlewicz.grace@epa.gov l I. Data 1,778 Chemicals 3,239 Structure descriptors (chm) 820 Bioactivity assays (bio) ToxCast 574 Apical outcomes (tox) ToxRefDB II. Define Local neighborhoods Use K-means analysis to group chemicals by similarity Use cluster stability analysis ~ 100 local neighborhoods III. GenRA Use GenRA to predict apical outcomes in local neighbor hoods Evaluate impact descriptors (chm, bio, bc) on prediction Quantify uncertainty Read-across acceptance is based on a subjective expert judgement assessment No objective means of assessing performance of a read-across Critical need for an objective measure of uncertainty in read-across prediction Data – Representing chemicals 1,778 Chemicals from ToxCast Phases I, II, III Each chemical represented by binary chemical (chm), bioactivity (bio) and toxicity (tox) vectors: 3,239 binary chemical structure descriptors (RDKit): Morgan fingerprints, Molecular Access System (MACCS) keys, and topological torsion fingerprints. Presence of structural feature denoted as “1” 820 binary bioactivity descriptors from ToxCast: If chemical is active in an assay then “1” else “0” 574 apical outcomes from ToxRefDB aggregated at the level of guideline study and target organ. If there is a significant effect at target site “1” else “0” Data –in vivo toxicity information from ToxRefDB Local neighborhoods (Clusters) α ij k j β j α ij k j α β, i s Σ x s Σ = y ghbours nearestnei = k Jaccard similarity: Impacts GenRA – performance in each cluster Use GenRA to predict the similarity weighted toxicity scores for each Toxicity type (𝛽𝛽) Descriptor ={chm,bio,bc} (α ) No. of nearest neighbours (𝑘𝑘) Similarity score threshold ( 𝑠𝑠𝑖𝑖𝑖𝑖 𝛼𝛼) Calculate performance by comparing predicted 𝑦𝑦𝑡𝑡𝑡𝑡𝑡𝑡and true 𝑥𝑥𝑡𝑡𝑡𝑡𝑡𝑡for all chemicals using area under ROC curve (AUC) Analyzing local neighborhood of a target chemical Comparing the read-across performance between different toxicity effects and their chemical representations Assessing the impact of the number of neighbors and the similarity threshold on the read-across prediction Bioactivity descriptors were often found to be more predictive of in vivo toxicity outcomes than chemical descriptors. Predictions were still context dependent on the endpoint and the chemical neighborhood under study. GenRA provides a first step in a tiered approach of investigating the utility of bioactivity data in concert with chemical structural information to make read-across predictions, and for systematically evaluating the uncertainty in those predictions. Next steps in progress: • Use of other chemical descriptor sets that encode	poster
Innovative Research for a Sustainable Future www.epa.gov/research Concept Methods Results Additional Sources of Error Conclusion Replication of PBTK Models for Bisphenol A with High-Throughput TK Models Deep Compartment Clearance Compartment Chemical In Chemical Out Qhepatic Lung Blood Qcardiac Qliver Qgut Qrichly perfused Richly Perfused Blood Gut Blood Gut Lumen QGFR Richly Perfused Tissue Liver Blood Liver Tissue Qkidney Lung Tissue CLmetabolism Tissue Blood Kidney Tissue Qgut Arterial Blood Venous Blood Gut Tissue kgutabs Poorly Perfused Tissue Poorly Perfused Blood Doerge i.v. 0.1 mg/kg 1 comp. 2 comp pbtk Yang 2013 pbtk with Yang CL AFE 2.8 2.7 2.7 1.5 2.3 RMSE (nM) 27 24 24 53 22 • High-throughput toxicokinetics can inform the regulation of thousands of untested chemicals currently in use as a new alternative method to animal testing. • Several physiologically-based toxicokinetic (PBTK) models have been developed for Bisphenol A in human and rat. • These models involve extra-hepatic metabolism and contain additional compartments and clearances relative to a basic TK model with parameters fit to in vivo data. • In a high-throughput context, using minimal in vitro and in silico data, models such as these are not practical because of the inability to determine the necessary parameters for many chemicals. • Here we evaluate the performance of various levels of model complexity in the prediction of BPA TK. Chemical Out Compartment Chemical In • Three models from the R package ‘httk’, a PBTK, 2 compartment, and 1 compartment model, were compared against 2 human and 3 rat models from the literature, all evaluated against in vivo data. • Three of the rat studies used iv dosing, one simulating steady-state. The rest of the studies used oral dosing and single doses. • Literature models were translated to code and simulated where possible. • Root-mean-square-error (RMSE, the square root of the average squared difference in measured and predicted concentrations) and average fold error (AFE, the geometric mean of the quotient of the measured and predicted concentrations when the dividend is larger than the divisor) were used as metrics in the evaluation. • Non-restrictive clearance was used, where the total rather than free concentration is subject to clearance. • In the majority of cases, all ‘httk’ models predicted the in vivo data within an order of magnitude, with neither of the 2 compartment and pbtk models performing significantly better than the 1 compartment. Using the Yang et al. 2015 clearance value in rats, the pbtk model predicted the majority of data within a factor of 3. • In rats, the pbtk model predicted as well as the model in Yang et al. 2013 when using the same flow-limited clearance, both having AFE of 5.1, although in vivo measurements sometimes differed by more than a factor of 10 at the same time point. • A limited number of models were available for comparison due to poor reproducibility. • Depending on the necessary level of accuracy, simpler TK models successfully make predictions using limited in vitro and in silico data, with the advantage of greater reproducibility and fewer sources for error. • Enterohepatic recirculation is likely responsible for the changes in the effective elimination rate of the literature models, especially noticeable in rat. This requires additional modeling of the metabolites. • Models were not fully reproducible, due to lack of information or other problems. Many other BPA models could not be included in the analysis for this reason. Additionally, parameters were used in reproduced models not mentioned in the corresponding paper. • Compounds with very abnormal behavior such as PFOS and PFOA cannot be accurately predicted with high- throughput models. This poster dose not necessarily reflect EPA policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. 3201/P841 Human Evaluation Rat Steady State Evaluation Rat Single Dose Eva	poster
Looking above the cloud deck of GJ 3470b Spandan Dash1, Matteo Brogi1,2 and Siddharth Gandhi3 1. Department of Physics, University of Warwick, Coventry, UK, CV47AL 2. Department of Physics, University of Turin, 1-10125 Torino, Italy 3. Leiden Observatory, Leiden University, Neils Bohrweg 2, 2333 CA, The Netherlands INTRODUCTION METHODOLOGY RESULTS and DISCUSSION REFERENCES GJ 3470b Properties • Neptune sized but slightly less massive (14 ME < 17.2 ME for Neptune) [4] • P = 3.88 days, Transit time = 1.918 hours [4] • Eccentric orbit – values of e vary quite a lot in literature – can go from slightly eccentric 0.017 to quite eccentric 0.114! [4] • Orbits an M-dwarf [4] but in a polar orbit [5] • Equilibrium temperature 600 K – Hence, warm Neptune – with evidence of clouds [1]. H2O detection but CH4 depletion[1] Fall due to Mie scattering? [1] High Resolution spectroscopy can look above a higher layer of clouds which proves difficult for low res! Figure reproduced from [2]. Figure reproduced from [1]. Spectra (time) Wavelength (pixel) Order 3D flux cuboid for each night Best fit H2O model to low resolution data Model Selection on a grid • ‘Goodness’ of a night is determined by whether we can detect 1x of an artificial exoplanet signal injected into the data. Possible using both nights of CARMENES by processing data between the ingress and egress phases. • Our best fit model to low res observations using just H2O and a cloud cover at 10-2.3 bar shows a detection (>5σ for Panel (e)) by combining both nights of observations with 1 times the best fit model injected in them. • In comparison, raw observations show no direct detection (Panel (f)) and prominent telluric contamination away from the exoplanet position. • Repeating the previous analysis for a grid of models will provide an estimate of how well a group of models are selected against the entire grid. Performing this on an isothermal grid with varying H2O abundances and cloud deck pressures results in both nights (Panels (e) and (f)) giving mostly consistent plots in terms of parameter selection. Combining nights strengthens the choice of selection to a strip of degenerate models, not all of which are in line with the finding in [1]. Combining 2 nights of observations with CARMENES does not show any direct detection of H2O above the cloud deck in the atmosphere of GJ 3470b. However, more good nights are necessary to conclude anything definite. A strong residual telluric feature also suggests the need for more aggressive detrending. Model Selection on an isothermal grid with varying H2O abundances and cloud deck pressures suggests a preference for a set of degenerate models with similar variances from the continuum which is wider than the finding from low resolution HST+Spitzer data. However, the grid assumed is not the same as previous studies and a more accurate grid of models with possible inclusion of two other molecules (CH4 and NH3) can be a potential solution to this non-conformity. This is currently being investigated. [1] Benneke, B., Knutson, H.A., Lothringer, J. et al. A sub-Neptune exoplanet with a low-metallicity methane-depleted atmosphere and Mie-scattering clouds. Nat Astron 3, 813–821 (2019). https://doi.org/10.1038/s41550-019-0800-5 [2] Siddharth Gandhi, Matteo Brogi, Rebecca K Webb, Seeing above the clouds with high-resolution spectroscopy, Monthly Notices of the Royal Astronomical Society, Volume 498, Issue 1, October 2020, Pages 194–204, https://doi.org/10.1093/mnras/staa2424 [3] Matteo Brogi and Michael R. Line 2019 AJ 157 114, https://doi.org/10.3847/1538-3881/aaffd3 [4] NASA Exoplanet Archive: https://exoplanetarchive.ipac.caltech.edu/overview/gj%203470b [5] Stefànsson, Guđmundur, et al. "The Warm Neptune GJ 3470b Has a Polar Orbit." The Astrophysical Journal Letters 931.2 (2022): L15 The figure above shows that detection of molecules with high res spectroscopy becomes much easier even at high cloud decks because the cores of molecular lines at high res	poster
RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com OBJECTIVE The narrative perspective: The methods of empirical studies: Paired Samples Test before and after being exposed to HT narratives; Sample: 38 Ukrainian humanity students representing the youth as a vulnerable category (gender 87% of females); Case study: 35 media stories highlighted by anti- trafficking campaigns were analysed; respondents were exposed to 4 stories in the survey Hypothesis and variables: HT-stories transmit supportive and encouraging messages to victims that 1) survival is possible; 2) it is worth of struggling if anyone gets into slavery conditions; 3) social reintegration is possible. These variables are measured statistically. MATERIAL AND METHODS Results are significant for “social reintegration is possible” variable (Pair 5 and Pair 6): p<0.29; p<0.015 RESULTS CONCLUSIONS - No “happy-end” beliefs; no strong evidence for “survival is possible”, no confidence that it is worth struggling; + high level of tolerance manifesting in acceptance that social reintegration of victims is positive. KEY WORDS: human trafficking, media storytelling, monomyth, empirical study, survival stories To verify whether audiences believe in the happy end of survival stories on the human trafficking situation. Borys Grinchenko Kyiv University, Ukraine Elina Paliichuk ONCE UPON A TIME… : IS THERE A HAPPY END IN A HUMAN TRAFFICKING MEDIA STORY? Before After A. Narrative features of HT media stories: 1) simple narrative monomyth structure; 2) reiterated cyclic construal; 3) the 1st person narrative perspective; 4) connotative and figurative language passive voice for showing dependent state of victims. B. Reading perceptions: tone of stories C. Paired Samples Statistics D. “Which fragment impressed you most of all?” Fragment 1 I knew that if I didn’t leave now, I would not be able to keep my son safe. My life meant nothing to me but his life meant everything. I was 20 years old and pregnant by my pimp. The further I got along in my pregnancy, the less I was able to “work” (sell sex) and the more violent he became. At around 7 months, he beat me so severely I was taken to the hospital. It was clear I had experienced violence of some kind. My teeth had been kicked in and my face was bruised and bloody. Despite my visible injuries, I wasn’t sure what to say to the hospital staff when they asked me if I needed help. I knew the consequences of outing my pimp for what he was and I was scared of what would happen if I told them the truth. So instead, dropping my head to avoid eye contact, I just told them that I was fine and didn’t need help. I want other survivors who may be considering leaving but are not sure where to turn or who may be afraid to call the hotline to know this: Making that first call is scary but nothing changes if you don’t change something yourself. Fragment 2 After six long years trapped in the human trafficking networks that brought me to the United States – thanks to God – I got out alive. With the help of a good Samaritan, I’m now free from that world, where I was forced to sell my body. It wasn’t easy to leave. I tried to commit suicide several times, thinking that was my only way out. I wasn’t going to give my traffickers the pleasure of killing me – I would rather have done that myself. But my attempts were never successful, and only God knows why. One day, a stranger approached me in a public place and struck up a conversation. I ignored her at first because I was afraid to even speak to anyone. I felt like I was being watched by my traffickers at all times, no matter where I went, but this time that woman would change my life for the better. My story doesn’t end there. I’d survived human trafficking, but the emotional trauma buried me deep, and I needed psychiatric help to get out. However, I was able to recover and find the will and strength to go on living. As part of the process, I also had to overcome my fear of trusting people.	poster
EVAL R(0,1,8) CONFIRM S(y,x) R(3,4,10) CONFIRM S(x,y) R(0,2,9) CONFIRM T(x,w) R(0,1,8) CONFIRM T(x,w) R(0,1,8) CONFIRM S(y,x) CONFIRM T(x,w) Fill in Boolean Formula (False AND True) OR True Project R(x,y,z) on (x,y) (0,1) Output (0,1) S E M I - J O I N S P A R A L L E L I S M G R O U P I N G Parallel Evaluation of Multi-Semi-Joins Jonny Daenen Frank Neven Tony Tan Stijn Vansummeren Poster presentation VLDB 2016, New Delhi, India Semi-Joins R ⋉S = πR.∗(R ⋊⋉S) Semi-Join Reducers GYM (Afrati et al. 2014) Yannakakis 1981 Reduce Communication Overhead Bernstein et al. 1981 R1 R2 R4 R3 R5 R6 R ⋊⋉S = (R ⋉S) ⋊⋉(S ⋉R) 0 1 1 1 1 1 4 3 8 2 2 8 SGF Queries GF ~ Semi-Join Algebra Stricly = no top-level Boolean combinations Nesting Strictly Guarded Fragment Z1 = SELECT aut FROM Amazon(title,aut,’bad’) WHERE BN(title,aut,’bad’) AND BD(title,aut,’bad’) Z2 = SELECT newttl FROM Upcoming(newttl,aut) WHERE NOT Z1(aut) MSJ 0,1 REQUEST R(0,1,8) S(x,y) 1,0 REQUEST R(0,1,8) S(y,x) 0 REQUEST R(0,1,8) T(x,w) 1,0 ASSERT S(x,y) 1,0 ASSERT S(y,x) 0 ASSERT T(x,w) REQUEST R(0,1,8) S(x,y) REQUEST R(0,1,8) S(y,x) REQUEST R(0,1,8) T(x,w) ASSERT S(x,y) ASSERT S(y,x) ASSERT T(x,w) 0,1 0 1,0 0 1 8 0 3 2 9 10 4 R 4 3 1 3 0 2 S 1 0 0 7 4 9 T 1 Guard Atom Conditional Atoms EVAL(R, ϕ) MSJ(X1, X2) MSJ(X3) SELECT x,y FROM R(x,y,z) WHERE S(x,y) AND S(y,x) OR NOT T(x,w) BSGF Queries Boolean Combination X1 = SELECT x,y,z FROM R(x,y,z) WHERE S(x,y) X2 = SELECT x,y,z FROM R(x,y,z) WHERE S(y,x) X3 = SELECT x,y,z FROM R(x,y,z) WHERE T(x,w) 2 Rounds 100% 200% 300% 400% 500% 600% Net Time SEQ 100% 100% 100% 100% 100% PAR 59% 54% 68% 63% 63% GREEDY 60% 98% 56% 60% 74% HIVE1 241% 243% 129% 208% 465% HIVE2 139% 134% 138% 115% 476% PIG 217% 245% 201% 189% 237% 1-ROUND 43% 200% 400% 600% 800% Total Time 100% 100% 100% 100% 100% 253% 242% 245% 191% 265% 238% 170% 149% 168% 186% 225% 218% 142% 78% 211% 324% 317% 319% 117% 640% 540% 614% 490% 373% 576% 120% 200% 400% 600% Input 100% 100% 100% 100% 100% 240% 240% 240% 240% 291% 171% 110% 120% 132% 139% 246% 246% 124% 140% 298% 361% 361% 361% 181% 437% 344% 433% 344% 344% 535% 70% 100% 200% 300% 400% 500% A1 A2 A3 A4 A5 Communication 100% 100% 100% 100% 100% 133% 133% 133% 133% 161% 133% 108% 90% 120% 124% 202% 202% 122% 101% 244% 322% 322% 322% 161% 389% 304% 304% 304% 304% 367% 70% 50% 100% 150% 100% 100% 22% 44% 17% 36% 83% 69% 59% 92% 44% 131% 18% 100% 400% 700% 1000% 100% 100% 361% 43% 106% 27% 844% 61% 479% 58% 560% 87% 18% 100% 300% 500% 700% 900% 100% 100% 411% 51% 80% 25% 749% 80% 570% 77% 653% 73% 18% 100% 300% 500% 700% B1 B2 100% 100% 206% 28% 76% 18% 620% 67% 505% 66% 323% 63% 18% 25% 50% 75% 100% 125% 150% 175% Net Time SEQ-UNIT 100% 100% 100% 100% PAR-UNIT 31% 51% 73% 32% GREEDY-SGF 56% 71% 78% 42% 25% 50% 75% 100% 125% 150% Total Time 100% 100% 100% 100% 107% 121% 108% 67% 58% 74% 92% 57% 25% 50% 75% 100% 125% 150% Input 100% 100% 100% 100% 104% 108% 100% 79% 52% 61% 64% 50% 25% 50% 75% 100% 125% C1 C2 C3 C4 Communication 100% 100% 100% 100% 105% 105% 95% 76% 69% 79% 85% 72% Icons from “Business People Icons 11” via vectorpage.com, Creative Commons Attribution 3.0 License Hasselt University National Taiwan University Université Libre de Bruxelles Problem Cloud (AWS, GCP, etc.) Pay-as-you-go Minimize resource usage Keep low time SGF Queries Minimize total time Parallel queries ∩ R ⋉S R ⋉T R ⋉U ⋉ ⋉ ⋉ R S T U BSGF-OPT NP-hard (Nykiel et al. 2010) Greedy: 0 0 0 +200 +300 -100 X1 X2 X3 X1 X2 X3 EVAL Z := X1 ∧(X2 ∨¬X3) MSJ X1 := R(x, y) ⋉S(x, z) MSJ X2 := R(x, y) ⋉T(y) MSJ X3 := R(x, y) ⋉U(x) (a) EVAL Z := X1 ∧(X2 ∨¬X3) MSJ X1 := R(x, y) ⋉S(x, z) X3 := R(x, y) ⋉U(x) MSJ X2 := R(x, y) ⋉T(y) (b) EVAL Z := X1 ∧(X2 ∨¬X3) MSJ X1 := R(x, y) ⋉S(x, z) X2 := R(x, y) ⋉T(y) X3 := R(x, y) ⋉U(x) (c) SGF-OPT NP-hard Greedy: for each leaf find group with highest overlap +dependencies if no overlap, add one query to new group else add a max. overlap query to group remove leaf Z ⋉I H ⋉Q R ⋉S ∧T G ⋉S ∧T Z ⋉I H ⋉Q R ⋉S ∧T G ⋉S ∧T Multi-BSGF Cost	poster
Translational Advances in Stem Cells for Diabetes Symposium \| Minaretein, Education City, Doha, Qatar \| March 8-9, 2023 Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis Background: The increased prevalence of obesity has led to a concomitant increase in the incidence of type 2 diabetes (T2D). Obesity-linked inflammation is the major cause of insulin resistance, contributing to the onset of T2D. Therefore, understanding the cellular mechanisms responsible for adipogenesis, the conversion of preadipocytes to adipocytes, is critical for identifying anti-diabetic therapeutic targets. Uhrf1 is a key epigenetic regulator that coordinates DNA methylation and histone modifications; however, the function of Uhrf1 in metabolic diseases is not known. Objective: Therefore, here, we aimed to understand the role of Uhrf1 in adipogenesis by studying Uhrf1 loss of function cells. Methods: We performed CRISPR/ Cas9 and shRNA-mediated gene silencing in addition to whole transcriptomics analysis on Uhrf1 KO cells. Results: We identified altered molecular and cellular pathways indicating that Uhrf1 is a critical factor required for adipocyte metabolism, and in its absence, cells exhibit adipocyte dysfunctions with higher levels of inflammatory markers. Conclusion: Our results highlight the possibility of Uhrf1 and its targets to have clinical applications in obesity and T2D treatment. Muneera Vakayil1,2, Aisha Madani1, Yasser Majeed1, and Nayef Mazloum1 1. Weill Cornell Medicine-Qatar, Doha, Qatar; 2. Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.	poster
BUTANEXT: NEXT GENERATION BIOBUTANOL BUTANEXT CHALLENGES Develop a two-step (mechanical-micronising & chemical-enzymatic pretreatment technology) that is versatile (works with different types of lignocellulosic feedstocks and wastes including recalcitrant materials) and low cost (reduces energy demands between 15-25%) both in terms of CAPEX and associated downstream OPEX for hydrolytic processing Reduce enzyme dosage and costs (up to 25%) using a boosting cocktail, adapted to the Clostridium butanol fermentation process. Increase fermentation efficiency by improving the butanol tolerance using non-GMO techniques to produce homo- fermentative next generation microorganisms, high productivity fermentation with in-situ product recovery (ISPR). The project targets a 2-fold increase in volumetric productivity versus a conventional ABE batch process. Validate the technical performance of the whole integrated process from feedstock handling to product recovery in a centralised pilot facility (100L fermentation scale). Perform a techno-economic and sustainability assessment of the integrated process in order to evaluate and guide further process developments and upscaling. ACKNOWLEDGEMENTS MetGen Oy for the supply of enzymes for enzymatic hydrolysis assays. The ButaNexT project has received funding from the European Union Horizon 2020 Research and innovation Programme under grant agreement n° 640462 Inés DEL CAMPO/ Irantzu ALEGRIA/ David SANCHEZ National Renewable Energy Centre (CENER) – Biomass Department. C/ Ciudad de la Innovación 7. 31621 Sarriguren, Navarra (Spain). Tel: +34-948-25-28-00. / idelcampo@cener.com/ialegria@cener.com/ dsanchez@cener.com Tim Davies/ Jenna Hewitt.Greenbiologics Ltd. ButaNexT@greenbiologics.com. Alvaro Pallares/Clemente Garcia. Técnicas Reunidas.apallares@tecnicasreunidas.es /cgredondo@tecnicasreunidas.es. Heleen De Wever/ Wouter Van Hecke. Vlaamse Instelling Voor Technologisch Onderzoek N.V.(VITO). heleen.dewever@vito.be / Wouter.vanhecke@vito.be. Magìn Lapuerta/David Fernández. University of Castilla la Mancha. Magin.Lapuerta@uclm.es / davidfdez232@gmail.com. Lucy Natrass. E4tech Limited. Lucy.natrass@e4tech.com. Bob Crawford. C-TECH Innovation Limited. bob.crawford@ctechinnovation.com. Juan Sanciñena. Zabala Innovation Consulting. JSancinena@zabala.es / Guillaume Corradino. Greenovate Europe. Guillaume.Corradino@greenovate.eu THE PROJECT TEAM BUTANEXT OBJECTIVES ButaNexT aims to develop and validate a cheaper, more energy saving, social and environmentally friendly integrated process able to efficiently convert sustainable feedstocks (lignocellulosic biomass and wastes) into biobutanol and define optimal biobutanol blends with fossil fuels and conventional biofuels (ethanol and biodiesel). Overall, the project aims to: • Validate for a relevant commercial concept significant cost reductions in biobutanol production vs 1st generation biobutanol production using the ABE process with starch. ButaNexT aims to reduce costs by up to 50% (targeting $800/T). The aim is to achieve price parity with the “best in class” bioethanol and biodiesel production in the EU. • Demonstrate enhanced energy balances and reduced carbon emissions vs 1st generation biofuel production. A reduction of 85% GHG emissions compared with fossil fuels (gasoline) is targeted. • Demonstrate butanol superior properties as fuel extender by optimising blends with gasoline and diesel and conventional biofuels (ethanol & biodiesel) to improve their performance characteristics and reduce emissions. The most promising diesel blends will be tested for performance and emissions in a diesel engine. • Demonstrate process sustainability via the utilisation of low cost and sustainable feedstocks (agricultural residues, energy crops and municipal wastes), the improvement of process conversion efficiencies (sugar and solvent yields and productivity) and the reduction of the environmental footprint (reduced energy requirements, water usag	poster
Nefrolitiasis indolora en adolescente deportista de alto rendimiento. Reporte de caso. Autor: Trujillo-Sánchez Alan Uriel Coautores: Lara-López Analisse, Trujillo-Sánchez Ximena Estefania Trujillo-Sánchez Francisco & Vega-Ramírez José Rafael. Universidad de Guadalajara; Centro Universitario de Ciencias de la Salud; Nuevo Hospital Civil de Guadalajara "Juan I. Menchaca". INTRODUCCIÓN Se solicitó estudio de sedimento urinario, donde se encontraron eritrocitos dismórficos. Tras sospecha de patología glomerular, se complementa el abordaje con proteinuria de 24 horas (875 mg). Se indica biopsia renal percutánea guiada por ultrasonido, reportándose nefropatía por IgA. JUSTIFICACIÓN CONCLUSIONES Es importante considerar nefrolitiasis en pacientes jóvenes y atletas, incluso cuando no se presentan síntomas típicos, ya que ante la sospecha diagnóstica de nefrolitiasis y una evaluación integral se puede llegar al diagnóstico de certeza, en este caso la nefropatía por IgA. Referencias: 1. Clark M, Aronoff S, Del Vecchio M. Etiologies of asymptomatic microscopic hematuria in children - systematic review of 1092 subjects. Diagnosis (Berl). 2015;2(4):211-216. doi:10.1515/dx-2015-0020 2. Expert Panel on Pediatric Imaging:, Dillman JR, Rigsby CK, et al. ACR Appropriateness Criteria® Hematuria-Child. J Am Coll Radiol. 2018;15(5S):S91-S103. doi:10.1016/j.jacr.2018.03.022 3. Marra G, Taroni F, Berrettini A, Montanari E, Manzoni G, Montini G. Pediatric nephrolithiasis: a systematic approach from diagnosis to treatment. J Nephrol. 2019;32(2):199-210. doi:10.1007/s40620-018-0487-1 4. Van Batavia JP, Tasian GE. Clinical effectiveness in the diagnosis and acute management of pediatric nephrolithiasis. Int J Surg. 2016;36(Pt D):698-704. doi:10.1016/j.ijsu.2016.11.030 5. Velásquez-Forero F, Esparza M, Salas A, Medeiros M, Toussaint G, Llach F. Risk factors evaluation for urolithiasis among children. Bol Med Hosp Infant Mex. 2016;73(4):228-236. doi:10.1016/j.bmhimx.2016.05.006 Describir el caso clínico de un paciente con nefrolitiasis y ausencia de dolor. El fin es contribuir al conocimiento de esta variante sintomatológica. REPORTE CLÍNICO Masculino de 17 años de edad, atleta de alto rendimiento, que acude a consulta por hematuria macroscópica (3 días de evolución), refiriendo que 3 meses atrás tuvo un episodio similar (Un día de duración), episodios que se presentaron después de ejercicio demandante, el primero acompañado de lumbalgia, el segundo episodio sin presencia de dolor u otra sintomatología. DISCUSIÓN Este caso ilustra la importancia de una evaluación integral en pacientes jóvenes con hematuria macroscópica recurrente, especialmente aquellos que practican deportes de alto rendimiento. Aunque la presencia de cálculos renales puede explicar inicialmente la hematuria, es fundamental investigar otras posibles causas, como las enfermedades glomerulares. Examen de orina confirma hematuria verdadera. Fue referido por médico que solicitó Urotac, reportando nefrolitiasis derecha, contando con un lito de 1mm en el polo superior, además de tres quistes simples, el mayor de 1.4 cm. PROTOCOLO DIAGNÓSTICO INTRODUCCIÓN La nefrolitiasis es una patología que afecta a una parte significativa de la población, siendo más común en hombres. Generalmente se presenta con dolor lumbar intenso y cólicos renales, aunque en casos atípicos, como en este paciente joven atleta de alto rendimiento, los síntomas pueden ser sutiles o incluso estar ausentes, lo que dificulta un diagnóstico precoz. Figura A, B, C y D. Resultados obtenidos de la biopsia renal. C JUSTIFICACIÓN DISCUSIÓN INTRODUCCIÓN A C B D A Congreso de Actualidades Médicas de Pregrado ‘’CAMED’’.	poster
Production of ATMPs: What are the specificities for quality aspects? Aurélie Mahalatchimy1, Eloïse Gennet2, Michael Morrison3, Véronique Andrieu4, Julie Véran5, Florence Sabatier6 1 Permanent Researcher in law at the French National Centre for Scientific Research (CNRS, CR), Law Faculty, UMR 7318 DICE CERIC, CNRS, Aix Marseille University, Toulon University, Aix-en-Provence, France; 2 Post-doctoral Researcher in Law, Law Faculty, UMR 7318 International, Comparative and European laws (DICE) CERIC, CNRS, Aix- Marseille University, Toulon University, Aix-en-Provence, France; 3 Senior Research Fellow in Social Sciences, Centre for Health Law and Emerging Technologies (HeLEX), University of Oxford, United Kingdom; 4 Senior lecturer in Industrial Pharmacy and Pharmaceutical Regulation, Faculty of Pharmacy, Aix-Marseille University, Research Unit Microbes Evolution Phylogeny and Infection (MEPHI) Aix-Marseille University, IRD, France; 5 Responsible of Cell therapy/Advanced Therapy Medicinal Products’ production at Marseille Public Hospital (AP-HM), Biotherapies Clinical Investigation Center, France; 6 Professor of Hematology and Biotherapy, Pharmaceutical Sciences Faculty, C2VN INSERM INRAe 1263 AIX Marseille University, Director of the cell therapy research centre at Marseille Public Hospital (AP-HM), France. Acknowledgements: This work has been supported by ANR-funded I-BioLex project (ANR-20-CE26-0007-01, coord. A. Mahalatchimy). M. Morrison is funded by the Leverhulme Trust through grant no RPG-2017-330. INTRODUCTION Advanced Therapy Medicinal Products (ATMPs) is a European classification of medicinal products based on genes, cells and tissues that have been specifically regulated in the European Union (EU) from 2007. Their manufacturing (i.e. their production) raises specific challenges for ensuring quality and complying with regulatory requirements in order to obtain manufacturing and marketing authorizations. Hence, on top of its guideline on the manufacturing of Biological active substances and Medicinal Products for Human Use (26 June 2018, 25 pages revised to consider the new ATMP guidelines), the European Commission also issued Good Manufacturing Practice specific to Advanced Therapy Medicinal Products (22 November 2017, very detailed text of 90 pages). Our hypothesis is that the biological nature that commonly characterizes ATMPs and biologicals may give rise to significant similarities in the manufacturing aspects as addressed by the respective guidelines. Through a comparative textual analysis of the GMP guidelines for biological medicinal products and ATMPs, this poster will highlight the key areas of similarities and differences. This analysis reveals why we have two different texts and whether they are based on substantial differences regarding production between ATMPs and other types of biological medicinal products. DISCUSSION & CONCLUSION Explicitly stated that the text on biologicals does not apply to ATMPs which are covered by specific guidelines, but the two texts share common aspects related to the biological nature of the product: Relevance of having two distinct and exclusive texts? The two texts could benefit from being formulated in a more similar manner to facilitate full understanding and implementation by stakeholders, especially manufacturers. COMMON TOPICS Main similarities Manipulation of raw and starting materials of biological origin raising common risks and challenges of quality reproducibility and sustainability, traceability and risk of cross or exogenous contaminations (compatibility of containments, importance of process controls, strategy for initial and final certification and batch release) Similar spirit of the two texts § Crucial role of manufacturing and control processes in determining the quality § Biological origin and related inherent variability à requested standards of quality SPECIFICITIES OF BIOLOGICALS VERSUS ATMPs ATMPS BIOLOGICALS Specific risks as presented in the scopes and	poster
Use of a 3D printed auxiliary module for the quality improvement of Ni-P/SiC nanocomposite coatings A. Chouliara1,2, E. Papaioannou1, K. Mavronasou1, A. Bairamis1, A. Grigoropoulos1, A. Zoikis Karathanasis1 1Creative Nano PC, 4 Leventi Street, Peristeri, 12132 Athens, Greece 2Department of Material Science, School of Natural Sciences, University of Patras, 26504 Rio, Patras, Greece e-mail: anastasiachouliara22@gmail.com; e.papaioannou@creativenano.gr INTRODUCTION Ni-P/SiC composite electroplated coatings are considered as one of the most cost-effective and best-performing combinations that could replace hard chromium coatings, due to their excellent microhardness, as well as wear and corrosion resistance. These properties depend, among others, on the phosphorus content of the Ni-P matrix and the amount, distribution and particle size of the embedded SiC nanoparticles (NPs) [1]. Ni-P/SiC coatings can be divided in three main categories: low (1-5%), medium (5-8%) and high phosphorous content (above 9%) [2]. Pillai et al. observed that the incorporation of phosphorous in the nickel lattice can reduce the nickel grain size from microns to nanometers.[3] In addition, the utilization of pulse current electroplating has been shown to improve the quality and the properties of the Ni-P/SiC coatings [4, 5]. Nevertheless, the electroplating process also depends on other factors such as the design and actual set-up of the electroplating cell, the hydrodynamic conditions and the positioning and geometrical characteristics of the anode and the cathode. In this work, the modification of the electrolytic cell set up by designing and printing a plastic auxiliary module, made by ABS with the aid of a Fused Filament 3D printer is presented. This module was installed in the bath to alter the hydrodynamic conditions in the area of the cathode. The effect of the current density and the duty cycle on the pulse current Ni-P/SiC electrodeposition was subsequently investigated. REFERENCES [1] X. Yuan et al. (2009), Intern. Journal of Minerals, Metal. and Mater. 16, 444-451. [2] A. Lelevic et al. (2019), Surf. Coat. Tech. 369, 198-220. [3] A. M. Pillai et al. (2012), J. Coat. Technol. Res. 9, 785-797. [4] L. Wang et al. (2006), Scripta Mater. 55, 657-660. [5] A. Zoikis-Karathanasis et al. (2010), J. Alloys Compd. 494, 396-403. This project has received funding from the European Union’s Horizon 2020 research and innovation programmes under grant agreement No 862296, “Sabydoma” and grant agreement No 862583, ‘’NanoPat’’. CONCLUSIONS • A 3D printed barrier designed and printed using ABS filament in a FFF 3D printer was used to improve hydrodynamic conditions during electroplating. • The 3D printed barrier enhances the incorporation SiC NPs in the Ni-P metal matrix. • Optimization of duty cycle and current density in Ni-P/SiC electroplating produced the best Ni-P/SiC coating at f = 10 Hz, duty cycle = 37% and current density= 3 A/dm2 • A microhardness of 865 HV was obtained. Ni/SiC electrolyte g/L NiSO4∙6H2O 260 NiCl2∙6H2O 48 H3PO3 40 H3PO4 20 Saccharin 2 SDS surfactant 2.5 SiC NPs 10 Operating conditions pH = 2, T = 50 °C, Pulsed current with 20, 30, 35, 37and 40 % duty cycle, f = 10 Hz, Current density= 2, 2.3, 2.5, 2.7 and 3 A/dm2 , t = 5 h Figure 5. Optical microscope images (100x) of Ni-P/SiC coatings at (a) 20% (b) 30% (c) 35% (d) 37% and (e) 40% duty cycle at (f) 0.2 (g) 0.23 (h) 0.25 (i) 0.27 and (j) 0.3 A/dm2 current density. Figure 7. Microhardness and SiC content versus duty cycle (left) and current density (right) Figure 3. Comparison of silicon content in Ni-P/SiC coatings w and w/o 3D printed barrier Table 1. Ni-P/SiC electrolyte bath composition and Electroplating conditions Optimization of plating parameters After the establishment of the critical contribution of the 3D printed barrier, the plating parameters were optimized. Firstly, five different values for the duty cycle and the current density were examined. Moreover, particle size was m	poster
www. ecotoxchip.ca Nil Basu1, Doug Crump2, Markus Hecker3, Jessica Head1, Gordon Hickey1, Natacha Hogan3, Steve Maguire1,2, Jianguo Xia1 1-McGill University, Montreal, Canada; 2-Environment and Climate Change Canada, Ottawa; 3-University Saskatchewan, Saskatoon, Canada; 2-University of Sydney, Australia Contact: info@ecotoxchip.ca; www.ecotoxchip.ca; www.ecotoxxplorer.ca ECOTOXCHIP: A TOXICOGENOMICS TOOL FOR CHEMICAL PRIORITIZATION AND ENVIRONMENTAL MANAGEMENT CHALLENGE • Chemical contamination threatens the health of humans and wildlife globally • Regulatory agencies and businesses are tasked to manage chemicals but are challenged: • many chemicals (e.g., 4.3K in Canada, 84K in USA, 101K in EU) need to be tested within short timeframes; • mandate to monitor many complex environmental samples (e.g., sediment, water, effluents); • testing is costly, time-consuming, and uses many animals; • tests on limited model species poorly predict risk in native species of concern. Urgent worldwide demand for improved testing tools that are more efficient, affordable, flexible, predictive, and less dependent on live animal studies ACKNOWLEDGEMENTS Funders: Génome Québec, Genome Prairie, Genome Canada, Environment and Climate Change Canada, the Government of Canada, the University of Saskatchewan, and McGill University People: Pascal Poulin (Project Manager), Emily Boulanger, Jenny Eng, Anita Masse (Local Project Managers), several graduate students, postdoctoral fellows, and technicians, staff at Génome Québec, Genome Prairie, and Genome Canada Research Oversight Committee: Drs. Nancy Denslow (chair), Kevin Crofton, Daniel Schlenk, Roy Suddaby, and Carole Yauk Core Partners: Government (Environment & Climate Change Canada, US Army Corps of Engineers, US EPA) & Business (SGS AXYS, Qiagen, Shell USA) Global paradigm shift in toxicity testing from historical whole-organism testing to mechanistic studies Human Health: • U.S. National Research Council’s “Toxicity Testing in the 21st Century-Vision and Strategy” • New Approach Methods - NAMs (e.g., toxicogenomic tools, alternative testing strategies) and stakeholder acceptance helping to transform the field Ecological Risk Assessment: • Avian ToxChip qPCR array developed by Environment and Climate Change Canada researchers via commercial partnership: à used to screen and prioritize chemicals; study real-world contaminated sites à embraced by Canadian regulators, environmental monitoring programs, and the scientific community OPPORTUNITY PROJECT DELIVERABLES 1. EcoToxChips for three key vertebrate model species used globally in ecological risk assessment (fathead minnow, Japanese quail, Xenopus laevis; fish, bird, frog); 2. EcoToxChips for three native species of commercial, recreational, and Aboriginal concern (rainbow trout, double- crested cormorant, northern leopard frog); 3. EcoToxXplorer.ca is an online and intuitive data evaluation tool that provides functions to allow users to upload EcoToxChip data and interpret results; and 4. Technical Guidance Document is informed by our GE3LS (social sciences) research and will be a government-vetted resource to advise end-users on how to adopt EcoToxChips. ACTIVITIES & UPDATE (60 month) Deliverable 1: • Currently we have EcoToxChips for Japanese quail (v0.1, v1), fathead minnow (v0.1, v1), and Xenopus laevis (v0.1, v1) • Moving ahead, the goal is to test these in a range of diverse case studies which can be viewed on our project website (http://www.ecotoxchip.ca/case.html) Deliverable 2: • Native species EcoToxChips have largely been designed, with production scheduled for late 2021 Deliverable 3: • Design and use of EcoToxXplorer.ca is well underway (you can use the tool!) • Refinement of algorithms that consider relevant approaches (points of departure, chemo- informatics, gene set signatures) to support interactive data mining and exploration • We are now evaluating different gene prioritization approaches based on this resource Deliverable 4: • T	poster
ABSTRACT The RDP was created to systematically describe the current data licensing landscape from the perspective of data aggregation, reuse, and redistribution of publicly funded biological & biomedical data resources. We hope to engage the scientific community in discussion regarding the legal use and reuse of scientific data. EXAMPLE SCORES IMPLICATIONS SCORE OVERVIEW RUBRIC AT A GLANCE LICENSE HETEROGENEITY Evaluating scientific data licensing with the (Re)usable Data Project Technical, logistical, and legal barriers impede data reusability and interoperability, and are significant burden and expense. Being unable to integrate and redistribute our collective data resources blocks innovation and development of life-improving diagnostic & drug selection tools. Most seemingly “open data” does not provide legal permissions for reuse and redistribution. 5 star 3 out of 5 stars 56 sources 4 star 3 star 2 star 1 star 0 star 18% 21% 20% 18% 18% 5% custom unlicensed all rights reserved inconsistent GPL-3.0 MIT CC-BY-4.0 CC-BY-NC-4.0 CC-BY-ND-3.0 CC-BY-SA-3.0 CC-BY-SA-4.0 CC0-1.0 ODbL-1.0 public domain 22 5 3 5 1 1 8 1 3 1 1 3 1 1 permissive restrictive copyright unknown copyleft private pool 22 16 8 5 4 1 Public, discoverable, & standard • Is the license easily findable? • Is there one, unambiguous license? • Is the license standard? ? ? ? ? ?? To help biomedical research & research support communities understand & navigate the data licensing landscape, we created a rubric to determine the reusability of data resources and have applied it to 56 scientific data resources (e.g. databases) to date. Few restrictions on kind of reuse • Are all types of reuse (copying, editing, building upon, remixing, distributing) allowable? Easily accessible data • Is all data covered by the license? • Is the data in a reasonable place? • Is the data easily accessible in bulk? Complete scope • Are terms of reuse clearly defined without need for negotiation with data creators/curators? • Is the data easily accessible in bulk? Few restrictions on who can reuse • Can any type of user group reuse the data? 22 permissive 16 permissive 8 copyright 5 unknown 4 copyleft 1 private pool 22 custom 5 incon- sistent 5 unlicensed 3 all rights reserved 1 1 8 1 3 11 3 1 1 Non-permissive licenses are the largest group License landscape is very diverse ACKNOWLEDGEMENTS & INFO @monarchinit info@monarchinitiative.org See the full rubric at: http://reusabledata.org See the preprint at: https://doi.org/10.1101/282830 Community contributions welcome! https://github.com/reusabledata/reusabledata This heterogeneity and restrictiveness severely complicates the ability to combine & reuse data. Highly reusable data sources This work is supported by NIH Grants OT3TR002019, U24TR002306, R24OD011883, and the U.S. Department of Energy Contract No. DE-AC02-05CH11231. We would like to thank Arvin Paranjpe, Senior Technology Development Manager, OHSU, for his thoughtful discussion. SCORING BY CATEGORY 0 10 20 30 40 50 Have a violation Unknown No violations Clearly stated Accessible Comprehensive & non-negotiated Avoids restrictions on kinds of (re) use Avoids restrictions on who may (re) use 1. Oregon Clinical & Translational Research Institute, Oregon Health & Science University, Portland, Oregon, USA 2. Berkeley Bioinformatics Open-source Projects, Lawrence Berkeley National Laboratory, Berkeley, California, USA 3. OHSU Library, Oregon Health & Science University, Portland, Oregon, USA 4. Neurology, Oregon Health & Science University, Portland, Oregon, USA 5. Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA Nicole Vasilevsky 1, Seth Carbon 2, Robin Champieux 3, Julie A. McMurry 1,5, Lilly Winfree, Letisha R. Wyatt 4, Melissa A. Haendel 1,5 No license is found, but data is accessible. The license is clearly stated & standard, & has clear data access, but has terms that greatly limit reuse & redistribution. The license is custom, does not apply to all the data,	poster
GRMHD Simulations of accreting neutron stars with dipolar and complex magnetic fields Pushpita Das, Oliver Porth, Anna Watts Anton Pannekoek Institute for Astronomy University of Amsterdam Abstract Accreting neutron stars (NS) and accreting millisecond X-ray pulsars (AMXPs) are one of the most interesting laboratories to study the physics of compact objects. Recently, along with providing highly precise mass and radius measurements, NICER also indicted the requirement of complex magnetic field structures to explain the observed X-ray spectra in some of the isolated millisecond pulsars. Rotation-powered millisecond pulsars are assumed to have undergone significant magnetic field evolution during the accretion phase. However, the details of this process are still poorly understood. We performed a suite of GRMHD simulations of accretion onto neutron stars, contrasting dipolar with non- dipolar field structures. Besides exploring processes in different accretion regimes, the simulations inform on the variability properties of the hotspots which can aid in future pulse-profile modeling of accreting sources. Numerical Setup We solve ideal general relativistic magnetohydrodynamic equations using the Black Hole Accretion Code (BHAC) in Schwarzschild coordinates. A few details of the numerical setup is illustrated below. • Effective resolution: 𝑁! × 𝑁" = 1920 × 768 • We initialize the magnetosphere with 𝜎= 100 and 𝛽= 0.01. • We ensure force-free like conditions in the magnetosphere by modifying 𝑝, 𝜌and 𝑢∥following Tchekhovskoy et al., 2013 • At 𝑟= 𝑅⋆, we put outflow boundary conditions at the accreting regions, thus allowing all the materials to pass through the surface undisturbed. Dipoles For reference we show three different accretion states for stars with dipolar magnetic fields rotating at an angular frequency of 0.03𝑐%/𝐺𝑀corresponding to ~572 Hz. Depending on stellar magnetic strength we can push the magnetospheric radius in or out of the corotation radius leading to various accretion states (Parfrey et al., 2017). Figure 1 : Logarithmic density for different values of surface dipolar moment at a fixed snapshot of t = 24570𝐺𝑀/𝑐!. (a) boundary layer, (b) Channeled accretion and (c) propeller regime. Dashed and solid lines represent the corotation and the light cylinder radius respectively (also for all the other density profiles) 𝑟"# 𝑟"# 𝑟"# 𝑟$" 𝑟$" 𝑟$" Conclusions • Hotspot visibility : Number and size of stream are strongly affected by field geometry! • In the parameter regime that we consider, on an average, the neutron star is always spinning down. • The effective spin-down torque at the stellar surface in case of quadrupoles is smaller compared to dipoles for the same surface polar field strength. • Addition of a quadrupolar field enhances the mater torque (causing more spin-up torque) and less spin-down EM torque. • We observe 1ms variability in the temperature profiles. Whether this leads to an observational signature affecting pulse-profile modeling depends on the thermal timescale on the surface and the details of the radiation transport. This is left for future work. Quadrupoles • The initial opposite polarities of the stellar field in the upper and lower hemispheres has a huge impact on the geometry of the accretion flow. • Fig: 2 shows the time evolution of the disk for Q = 70 where the initial disk magnetic field is anti parallel to the stellar field in the northern hemisphere and parallel in the southern hemisphere. • The asymmetric disk-magnetosphere coupling modifies the initial quadrupolar magnetosphere to resemble a quadrudipolar field in the vicinity of the stellar surface. • Fig: 3 shows density profiles for different quadrupolar strengths. Depending upon quadrupolar moment, we get different accretion states. At the lowest quadrupolar moment (Q = 25), the disk crushes the northern closed zone leading to boundary layer accretion. Increasing quadrupolar strength (Q) mainly has two effects. First, it halts the dis	poster
Environmental damage assessment of conflict-affected coastal waters in Eastern Ukraine using ocean color Contact information Tetyana Kuchma, PhD, tanyakuchma@gmail.com +38-050-587-2066 Tetyana Kuchma National University of Kyiv-Mohyla Academy, Institute of agroecology and natural management, Kyiv, Ukraine Motivation The military action in Donbas region (eastern Ukraine) started from May 2014 among other devastating consequences affected the inland and coastal ecosystems. The recovery measures highly depend on the effectiveness of impact and da-mage assessment, but to this day the large area remains inaccessible for ground field studies. The objective of the research was to use the осеan color for the environmental changes detection due to hostilities influence. Result Time series of month-averaged values of SST, Chlorophyll-a, NO2, SO2 та CO were analyzed. A seasonal variability was demonstrated with the highest values between April-September and the minimum in October-March for most of the parameters, except of NO2. Thus the seasonal-averaged dynamics and trends was also analyzed. seasonal mean Methodology and study area In conflict zone the considerable anthropogenic pressure on the environment due to coal and ore mining and metallurgical production was multiplied by massive use of shell artillery. Based on satellite imagery analysis the 15,505 shell bursts craters were detected on the territory of 225 km2 over the period of 2014-2015. Thus a significant amount of chemical compound, such as CO, CO2, NO, N2O, CH2О, and SO2, has been released into the atmosphere. Water and soil samples revealed a considerable amount of heavy metals, sulfates and nitrates at the shell explosion sites [1,2] It should also be emphasized that armed confrontation zone is located in close proximity to the Sea of Azov coastal waters (in 100-km distance) and the hydrological conditions of the Sea of Azov due to its inland situation, are largely formed by external factors such as temperature, river run-off, etc. The methodology was based on the analysis of the variability of sea upper layer parameters and its relation to the atmospheric factors which affect them. The dynamics of Sea Surface Temperature (SST), Chlorophyll-a (Chl-a) and Particulate organic carbon (POC) concentration over 12-year period (2005- 2016) were studied using Modis imagery as the sea upper layer parameters and the dynamics of NO2, SO2 and CO concentration, obtained using OMI and AIRS sensors were used as indicators of atmospheric change. Data was downloaded from https://giovanni.gsfc.nasa.gov A significant decrease in Chl-a concentration in summer period was showed, starting in 2007 and followed by slight increase in 2014. SST positive trend showed a sea surface water warming, especially in summer period. The sharp increase in CO concentration was evident in August 2014, which could be associated with the beginning of intense artillery shelling and fires, as about 3,000 fires occurred in summer of 2014 in eastern Ukraine [1]. The increasing of NO2 and SO2 concentration in winter, and decrease in warm season was showed in recent years. References 1. Military Conflict in Eastern Ukraine - Civilization Challenges to Humanity - «Environment-People-Law», 2015. http://epl.org.ua/wp- content/uploads/2017/04/1817_EPL_Posibnuk_ATO_English.pdf 2. Civilization Challenges to Humanity»Assessment of the Environmental Impact of Military Activities during the Yugoslavia Conflict. Preliminary findings. — The regional Environmental Center for Central and Eastern Europe, 1999. http://www.monde-diplomatique.fr/cahier/kosovo/ecologie-rapport The analysis of year-averaged spatial distribution in 2015 showed that the highest Chl-a concentration is observed in northern-eastern coastal waters, and the highest SO2 and NO2 values are revealed in Donbas area and around big cities. Conclusion 1. Based on the regression analysis the relationship between coastal water parameters and atmospheric variability is	poster
INTRODUCTION The stellar evolutionary theory, the stellar pulsation and binaries are the three most common ways help astronomers to study celestial objects as well as to study about the universes. The investigation and review by Murphy (2017) pointed out that the existence of the stars in binary and multiple systems outnumber of single stars by at least 2:1 (Murphy et al. 2017). With this work we arrived at the possible way the binarogram helpful to recognize the orbital peaks of low orbit delta Secuti stars from factious peaks with a strong confidence. Then, we obtained two a small kepler binaries with the method by modifying it. DATA AND MATHOD The method which we modified and used for detecting binarity is that of Balona (2014) using Kepler light curves. He discussed that the uniqueness of the method is that a direct periodogram of the orbital frequency is derived using all possible information to extract the time delay from the stellar pulsations. They also suggested that the particular advantage of using the time delay through constructing the binarogram curve in identifying that a Kepler pulsating star has a companion is that the curve displays the orbital frequencies from which all other orbital parameters are determined. The central messages of obtaining equal numerical values of forb at each pulsation frequency is that the causes of the time- delay is the presence of a companion of a Kepler pulsating star. And the reciprocal of this orbital frequency gives the orbital period of a star. RESULT AND DISCUSSION We modified the method through extracting several highest orbital frequencies with their corresponding a(sin(i)) from our final data which provides the banarograms at each pulsation frequencies. This is because of it can avoid several error may introduced during we read the numerical value of orbital frequencies from the graph directly. Then, we have introduced the horizontal vertical lines in previous binarogram so that clarify the how the orbital frequencies at each pulsation frequencies do not show a large variations unlike that of a(sin(i)). Figure-1: The three binarograms of KIC 4150611. The right panel is the modified binarogram which is the first out come of this our present work. The right panel is the modified of the middle one. Then we identified two δ Scuti stars wich has the orbital period of less than 50 d. That is KIC 8042044 and KIC 3952623 are 46.08 d and 19.5d respectively. These are shown in the figure-2 and fgure- 3. Figure-2: The modified binarogram (frequency versus a(sini)) of KIC 3952623 which shows the orbital frequency and period are 0.0217 d- and 46.08 respectively d. Figure-3: The modified binarogram of KIC 8042044 which shows the orbital frequency and period are0.0513 d- and 19.49 d respectively. CONCLUSSION AND FUTURE WORK This study shows that the orbital peak of KIC 8042044 and KIC 3952623 are 46.08 d and 19.5d respectively. The additional peaks in the binaroram of the second object needs further investigations. This shows thatit is possible to determine the orbital period of small orbits for a few binaries. Thus, the modified method is applicable to find a small orbit Kepler Binaries by overcoming others interference limit us to recognize the correct orbital peaks. We also intended to apply this modified binarogram on a plenty of unsolved problems pointed out in Murphy et. al (2017) and similar others. Acknowledgement This task includes data collected by the Kepler mission. Funding for the Kepler mission is provided by the NASA Science Mission directorate. YAM wish to thank the Kepler team for their generosity in allowing the data to be released and for their outstanding efforts which have made these results possible. REFERENCES L.A. Balona, 2014, Binary star detection using the time-delay method: application to 34 Kepler objects of interest, MNRAS 443, 1946–1954 S. Murpy, 2017, Finding binaries from phase modulation of pulsating stars with Kepler, Monthly Notices of the Royal Astron	poster
alexander.snegirev@ugent.be © 2022 Ghent University, Campus UFO, Technicum Blok 4 Sint-Pietersnieuwstraat 41, 9000 Gent Flame evolution modes Growing spherical segment Steady flame Unsteady transient flame Top extinction Bottom extinction Symmetric oscillations Non-symmetric oscillations Steady oscillations Full extinguishment Spiral Capuchin Incomplete recovery Incomplete recovery Complete recovery Until fuel termination Motivation and objectives What is studied? • Zero gravity diffusion flame • Very low momentum of fuel flow, Re < 10 • Flat fuel source • Stagnant atmosphere, various oxygen content Two prototypes studied to date • Jet laminar flame: larger Re • Spherical flame around a point-source (droplet or candle): much smaller size of fuel source Practicality • It is this kind of flame that develops when a condensed fuel (liquid or solid) burns • Flammability of such a condensed fuel is directly coupled with the stability of gaseous flame Objectives • To provide interpretation of the orbital experiment BRE (Flamenco), 2019-2021 • To develop the model and evaluate its capability • To explain the dramatic effects incurred by the reduced gravity • To investigate the extinction mechanism and to analyze transient flame dynamics This kind of flame has not been investigated earlier The flame of interest is dissimilar to these prototypes FIRE INCEPTION IN MICROGRAVITY ORBITAL EXPERIMENT BRE-FLAMENCO ONBOARD THE INTERNATIONAL SPACE STATION, 2019-2021 A. Snegirev Ghent University, Faculty of Engineering and Architecture Department of Structural Engineering and Building Materials (Combustion, Fire and Fire Safety) Radiative extinction • In normal and zero gravity, characteristic velocities differ by two orders of magnitude, so do the flame residence times (≈ 0.04 in 1g and 8 s in 0g) => • The radiative heat loss in zero gravity is much higher than that in normal gravity. Its ratio to the heat release rate is ≈ 0.08 (1g) and ≈ 0.7 (0g, prior to extinction) • Maximum flame temperature: ≈ 2100 K (1g) and ≈ 1200 K (0g, prior to extinction) • As a result, the zero-gravity flame cannot attain the steady state: the initial stage of the steady growth is interrupted by the local extinction followed by flame oscillation and extinguishment (unless the oxygen concentration is increased to 30-40%) The experiment 59+139 orbital tests (2019 and 2020-2021) • Oxygen mole fraction in the ambient atmosphere: 0.21-0.4 • Pressure: normal (14.3-14.7 psi) and reduced (8.1-10.3 psi) • Burner mass flux 1.5-11 g/(m2·s) • Fuels: C2H4 - N2 mixtures, CH4 - N2 mixtures (0, 33 and 50% N2) • Burners: 25-mm and 50-mm diameter Recordings and measurements • Video 30 fps • Burner surface temperatures and heat fluxes (center, off-center) • Remote radiometer (radiative fraction) • Filament temperatures • A. Snegirev, E. Kuznetsov, E. Markus, P. Dehghani, P. Sunderland, Transient dynamics of radiative extinction in low-momentum microgravity diffusion flames, Proc. Combust. Inst. 38 (2021) 4815-4823 https://doi.org/10.1016/j.proci.2020.06.110 • E. Kuznetsov, A. Snegirev, E. Markus, Radiative Extinction of Laminar Diffusion Flame above the Flat Porous Burner in Microgravity: a Computational Study, Combust. Explos. Shock Waves, 56:4 (2020) 394-411 https://doi.org/10.1134/S0010508220040036 • A. Snegirev, E. Kuznetsov, E. Markus, P. Dehghani, P. Sunderland. Transient dynamics of radiative extinction in low-momentum microgravity diffusion flames. 38th Int. Combust. Symp., Adelaide, Australia, 24 – 29 January 2021 (Paper 1J05: 19-01152 • Kuznetsov E., Snegirev A., Markus E., Radiative Extinction of a Diffusion Flame in Microgravity. Proc. Ninth International Seminar on Fire and Explosion Hazards, 21-26 April 2019, St. Petersburg, Russia, SPbPU, 2019, Vol. 1, pp. 214-224 http://doi.org/10.18720/spbpu/2/k19-73 Publications • A. Snegirev, On radiative extinction of microgravity diffusion flames, Combust. Flame 2022 (submitted) Approximate theory • ( ) 2 2 3 2 1 3 , ,0 , O , 4 4 O	poster
Characterizing cool giants in symbiotic binaries using the Gaia EDR3 data Jaroslav Merc1,2; Rudolf Gális2; Marek Wolf1 1Astronomical Institute of Charles University, 2 Institute of Physics, P. J. Šafárik University Jaroslav Merc Astronomical Institute of Charles University V Holešovičkách 2, 180 00 Prague, Czech Republic Email: jaroslav.merc@gmail.com Website: https://sirrah.troja.mff.cuni.cz/~merc/ http://astronomy.science.upjs.sk/symbiotics Contact 1. Gaia Collaboration et al. (2020). arXiv:2012.01533 2. Lindegren, L., Bastian, U., Biermann, M., Bombrun A., de Torres, A. et al. (2020). arXiv:2012.01742 3. Merc, J., Gális, R., & Wolf, M. (2019), Research Notes of the American Astronomical Society, 3, 28. 4. Merc, J., Gális, R., & Wolf, M. (2020a), Contributions of the Astronomical Observatory Skalnate Pleso, 50, 426. 5. Merc, J., Mikołajewska, J., Gromadzki, M., Gałan, C., Iłkiewicz, K., et al. (2020b). Astronomy & Astrophysics, 644, A49. 6. Mikołajewska, J. (2012), Baltic Astronomy, 21, 5. 7. Sion, E. M., Godon, P., Mikolajewska, J., & Katynski, M. (2019), The Astrophysical Journal, 874, 178. 8. Teyssier, F. (2019), Contributions of the Astronomical Observatory Skalnate Pleso, 49, 217. References Symbiotic stars are strongly interacting binaries, which consist of a cool giant of spectral type M (or less commonly K) and a hot compact star, mostly a white dwarf (see e. g. the review by Mikołajewska, 2012). Both stellar components radiate at distinct wavelength intervals (see Fig. 1). Their orbital periods range from hundreds to thousands of days. Symbiotic binaries are unique astrophysical laboratories in the study of the stellar evolution, mass transfer and accretion processes, stellar winds, jets, dust formation, or thermonuclear outbursts. Gaia observations made public in the Gaia EDR3 (Gaia Collaboration et al., 2020), as demonstrated in this contribution, could be very suitable for characterizing the Galactic symbiotic population. Introduction A factor that significantly limits analysis of the parameters of the components of symbiotic binaries is their unknown distance. Astrometric observations of the Gaia satellite can significantly help in this task. However, in the case of symbiotic binaries, many parallaxes are only poorly measured: some of them are even negative or are measured with large relative errors (Fig. 3). Moreover, the zero-point offset of parallaxes is present in the data (Lindegren et al., 2020). Another issue may be related to the binarity of symbiotics and their orbital motion, as the astrometric parameters from Gaia are obtained considering only the one-star model. In nearby long-period binaries, the shift caused by their orbital motion can be comparable to the effect caused by their parallax (e. g. as noted for AG Peg by Sion et al., 2019). Therefore, all the Gaia distance measurements for symbiotics must be interpreted with regards to these issues. In Fig. 4, we show the distribution of vertical distances of symbiotics from Galactic plane. Positions Thanks to several programs focused on discovering symbiotic binaries, the number of known symbiotic stars is growing rapidly in the recent decades. Based on the recent progress in the study of symbiotic stars, we have decided to prepare a new database of these interacting binaries (New Online Database of Symbiotic Variables; Merc et al., 2019). The purpose of the database is not only to serve as a catalogue of data for all known symbiotics with consistent references, but we have also prepared a web-portal for easy access to this information. For the catalogued symbiotic stars, we have prepared specific object pages covering all available information included in the database. Making the database online allows us to add new objects as soon as they are discovered and update data when new information becomes available. Database of symbiotics In addition to precise astrometric measurements, photometric data from the Gaia satellite could be used to monitor varia	poster
Selection on positive length variants contributed to genome shrinkage in Arabidopsis Robin Burns, Magnus Nordborg Gregor Mendel Institute of Plant Molecular Biology, Vienna BioCenter Introduction The genome of the outcrossing perennial A. lyrata (207Mb) is larger than that of the selfing annual A. thaliana (125Mb), despite the two species diverging only about 6 Mya. This difference was previously attributed to numerous small deletions occuring in A. thaliana after the species split [1], and this was based on the use of a single reference genome for both species. Could, instead of just deletions, selection acting against positive length variants from standing variation have contibuted to the smaller genome size of A. thaliana? By comparing whole genome alignments for multiple long read assemblies of both species. We find that these indels are segregating in A. lyrata in agreement with selection against positive length variants contributing to genome shrinkage. Examination of short reads for a population of A. lyrata is ongoing. or a b A. thaliana reference (125 Mb) A. lyrata reference (207 Mb) ancestor (~200 Mb - family average) ancestral population A. thaliana population A. lyrata population / = Presence/Absence of Indels 1. More than half the A. lyrata reference is missing from A. thaliana 2. Long read assemblies show that these same indels are segregating in A. lyrata 3. Kmer approach to calling presence or absence of indels in short reads A. ly A. th insertion Whole Genome Alignment k-mers 1. 2. 3. presence/absence Chromosome level assembly of 2 Nanopore A. lyrata genomes 7 published A. thaliana long read assemblies available [2] 5. References 4. Conclusions and follow up Search for matching k-mers in short Illumina reads in a population of A. lyrata lines k-mers specific to sequences present in A. lyrata reference but missing from A. thaliana Aly.Unaligned Ath.Unaligned Aly.Aligned Ath.Aligned Alyrata Athaliana 0.0e+00 5.0e+07 1.0e+08 1.5e+08 2.0e+08 Base−pairs N unassigned DNAtes RNAtes intergenic introns CDS a ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ●●●●● ● 0e+00 3e+07 6e+07 9e+07 0e+00 1e+06 2e+06 Size of indel Cumulative length species ● Alyrata b ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ●●●● ● 0e+00 1e+07 2e+07 3e+07 4e+07 0 20000 40000 60000 Size of indel Cumulative length species ● Athaliana c 0 30 60 lat Location of Arabidopsis lyrata sub-species A. lyrata lyrata A. lyrata arenicola A. lyrata petraea A. lyrata petraeaumbrosa Self compatible Self incompatible 4. 0 20000 40000 60000 2 4 6 Athaliana Individual Frequency count a 0.0e+00 2.5e+07 5.0e+07 7.5e+07 1.0e+08 Deletions Base pairs Species Al At b ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ● ● 0e+00 1e+07 2e+07 3e+07 0 500000 1000000 1500000 2000000 Size of indel Cumulative length (34Mb), N=21748 c Population level whole genome alignments reveal that regions related to genome size differences between the A. thaliana and A. lyrata references are segregating in A.lyrata. Caution for such future comparions. SNPs around the locations will be examined along with kmer analysis for a population of A. lyrata. How does selection act on these regions in A. lyrata. Different mating types? Use of outgroups hindere	poster
Genomics tools at your service Australian BioCommons provides bioinformatics tools that researchers ask for. We offer fully subsidised access to a range of services for Australian researchers. Galaxy Australia Genome Lab The simple web interface of Galaxy Australia opens up over 1,500 bioinformatics tools and 350 workflows to researchers - with no requirement for command line skills. Galaxy Australia’s Genome Lab provides quick access to ready-made workflows and powerful computation, and is complemented by the personalised support that you’d expect from a national service. Data preparation Genome assembly Genome annotation For more information about Galaxy Australia and the partnerships that make the Genome Lab possible, please visit usegalaxy.org.au	poster
Una población vulnerable de Hetaerina vulnerata (Odonata: Calopterygidae) en la zona urbana de la Ciudad de México Rocío J. Guzmán-Ojeda y Enrique González-Soriano Instituto de Biología, Departamento de Zoología, Universidad Nacional Autónoma de México. email: rocio.j.guzman@gmail.com Métodos y área de estudio Para conocer el estado de la población se muestrearon adultos por Captura-Marcaje-Recaptura de Septiembre a Noviembre de 2017 (Fig. 1). Se colocaron 138 parcelas de 3 m × 3 m (1,242 m2) en 186 m del cauce (Fig. 2), realizándose recorridos entre las 10:00 y 15:00 h. Se registraron datos meteorológicos cada hora a través de un higrómetro (temperatura y humedad) que se complementaron con las lecturas de la estación meteorológica más cercana (Centro de Ciencias de la Atmósfera, UNAM, a 4.5 km). Se calculó el patrón de dispersión a través del índice de Morisita (Iδ) [5]. Figura 2. Mapa del área de muestreo. Se colocaron parcelas entre los 100 – 400 m y 600 – 700 m dirección de la corriente. Figura 1. Macho adulto de H. vulnerata. Los individuos se marcaron con un identificador único usando un marcador indeleble a prueba de agua. Hetaerina vulnerata es una libélula que habita en cuerpos de agua corriente en buen estado de salud y con presencia de vegetación riparia [1, 2] además de poderse encontrar hasta por encima de los 2,000 msnm. Esta especie se pensaba extirpada de la zona urbana del valle de la Ciudad de México debido a la desaparición o contaminación de su hábitat [3]. Sin embargo, en 2016 se descubrió una población pequeña de esta especie en el Parque Nacional Fuentes Brotantes de Tlalpan (PNFB) [4]; dicha población se encuentra aislada por el ambiente urbano a su alrededor y en uno de los pocos lugares que aún tiene un cuerpo de agua lótico en buen estado de salud para la presencia de odonatos. El propósito de este trabajo es conocer la condición actual de la población de H. vulnerata en el PNFB. Hetaerina vulnerata en la Ciudad de México Literatura Citada [1] García-García et al. 2017. Hydrobiologia 785(1):19–33 [2] Williamson. 1923. Occas. Pap. Mus. Zool. (130) [3] Mendoza-Trejo & González-Soriano. 1999. pp. 215–216 en Biodiversidad de la región de montaña del sur de la Cuenca de México. [4] González-Soriano. 20116. pp. 285–289 en La biodiversidad en la Ciudad de México, vol. 2 [5] Morisita. 1959. pp. 215–235 in Memoirs of the Faculty of Science, Kyushu University, Series E, vol. 2 Capturas y recapturas diarias Se capturaron 68 individuos adultos maduros: 64 machos y 4 hembras. Las capturas iniciaron a partir de las 11:00 h, lo cual coincidió con la hora de radiación más alta de la temporada (Fig. 3), sin encontrarse un patrón por temperatura o humedad. Sólo se registraron 5 eventos de apareamiento, de los cuales en 4 se capturó a la hembra por primera y única ocasión (Fig. 3). Dispersión El patrón de dispersión fue agregado (Iδ = 3.08; F0 < F138 ∞(0.05)) (Fig. 4), tendiendo a perchar principalmente en áreas abiertas, iluminadas, dentro o contiguas a la corriente, y que contaran con la presencia de hierbas acuáticas, arbustos o rocas. En las perchas dominaron 4 especies vegetales, 3 acuáticas (Fig. 6), mientras que las otras 12 especies representaron menos de 2% cada una. Esto indica la importancia de la presencia de plantas acuáticas bajas para el hábitat de H. vulnerata. Figura 3. Capturas y radiación por hora. Las barras indican los individuos capturados y recapturados; (●) radiación registrada por hora (CCA, Sep-Oct 2017); () eventos de apareamiento. Figura 6. Proporción de perchas. La vegetación acuática y rocas dentro o contiguas a la corriente fueron las perchas más utilizadas por H. vulnerata. Próximos análisis • Calcular movimiento diario. • Estimar el tamaño poblacional. • Calcular la longevidad del adulto. * * * * Resultados Figura 5. Alturas de perchas. Figura 4. Dispersión de individuos adultos. Porción de parcelas entre 200 y 300 m del cauce. Los números indican capturas y recapturas por parcela. U	poster
Meat quality and lipid composition of loin and topside from dairy-beef crossbred yearling calves and 2-year-old steers Introduction Results and Discussion • Livestock farming is challenged with finding alternative production systems due to the current impacts on animal welfare, the environment and climate change. • Producing veal from surplus dairy calves within 10 days of birth leads to animal welfare concern and compromises the social licence to operate. • Alternative farming systems are being considered in New Zealand by producing meat from crossbred surplus dairy calves finished on pasture at 8-12 months of age [1]. • It remained unclear the differences in quality and lipid composition of meat produced from dairy-beef crossbred yearling calves finished on pasture compared to commercial beef. Aim Evaluate the meat quality and lipid composition of loin and topside from dairy-beef crossbred yearling calves compared to 2-year-old steers. Methodology • Striploin and topside were obtained from yearling calves (n=12) and 2-year-old steers (n=12) of dairy-beef crossbred cattle finished on pasture. Meat samples were wet-aged at -1.5°C for 21 days (23 days post-mortem) and subsamples were taken for determining meat quality and nutritional compositions as shown in Fig 1. • Total fatty acids, %IMF and %MUFA were lower (P<0.05), while % PUFA, n-6 and n-3 PUFA were higher (P<0.05) in yearling calves. • Both meat types had healthy n-6:n-3 ratios (≤4.0) while higher values were observed in topside from 2-year-old steers than yearling calves. • The levels of vitamin A and β-carotene were lower (P<0.05) in meat from yearling than 2-year-old cattle. Conclusion • Beef from yearling calves and 2-year-old cattle differed in colour properties with similar cook loss and tenderness. • Producing beef from yearling calves can provide high-quality meat to meet the growing demand for lean meat products, while contributing to mitigate issues related to animal welfare and the environmental impact of meat production. Fig 1. A schematic illustration of meat samples and experimental design of this study. REFERENCES [1] Hunt, J. J., 2019, New Zealand Journal of Animal Science and Production 79: 153-155. . [2] Agnew, M.P., 2019, Metabolites 9(9): 189. [3] Nimalaratne, C., et al. 2014, Food Research International 66: 69-77. ACKNOWLEDGEMENTS This work was supported by AgResearch Strategic Science Investment Fund, SSIF-A27235 (Consumer Experience: pathways to premium foods). Renyu Zhang Romera, A., Deb- choudhury, S. Jacob, N., Alfante, R., Agnew, M., Farouk, M. M., & Realini, C. E* AgResearch Ltd, New Zealand Carolina.Realini@agresearch.co.nz Table 1 Meat quality traits, fat-soluble vitamins (mg/g meat), intramuscular fat (IMF) and fatty acid profile (g/100 g meat) of loin and topside from yearling and 2-year-old beef. • Meat pH values were measured using a portable pH probe and in- strumental colour (CIE L, a* and b*) was measured at three ran- dom positions of steaks using a Minolta Chroma Meter (CR-400). • Shear force (N) of cooked steaks (core temperature of 75°C) was measured by shearing perpendicular to the fibre axis direction of cross sections (10 mm×10 mm) using a Warner-Bratzler blade. • Intramuscular fat (IMF) content and fatty acids (FA) profile of sam- ples were analysed by a direct trans-methylation method [2]. • Fat-soluble vitamins (vitamin A and E, Lutein, β-carotene) were de- termined based on the method by Nimalaratne et al. [3]. • Data were analysed using R software and “lme4” and “predictmeans” packages. One-way ANOVA and Tukey’s honest significant difference were used to separate the means at P<0.05. IMF = intramuscular fat. SFA = saturated fatty acids = C10:0 + C12:0 + C14:0 + C15:0 + C16:0 + C17:0 + C18:0 + C20:0 + C24:0. BCFA = branched chain fatty acids = Iso-C15:0 + Anteiso-C15:0 + Iso-C16:0 + Iso-C17:0 + Anteiso-C17:0. MUFA = monounsaturated fatty acids = C14:1 + C16:1 + C17:1 + C18:1 trans-9 + C18:1 trans-11 + C18:1 cis-9 + C18:1	poster
An online repository of body segment parameter models wspr.io/body-segment-param/ Will Robertson, School of Mechanical Engineering, 2016 Introduction Body segment parameter estimates of mass, moment of inertia, &c., is a requirement for biomechanical analyses. Errors in parameters propagate to calculated joint moments and muscle forces [1], in some cases leading to considerable sensitivity in results to segment parameter errors [2]. However, subject-speciﬁc modelling is time- consuming and there have been few studies on the variety of extant body segment pa- rameter models. These consist originally of cadaver studies completed before the 1970s, after which time medical scanning and photo- graphic approaches began to be used in more comprehensive studies. This work collates such studies into a pub- lic repository for general use and historic interest. The repository currently contains over twenty separate body segment param- eter models in studies conducted from 1860 to 2011. Relative mass models The relative mass models provide a scaling factor for the mass of each segment relative to the total mass of the subject. The repos- itory current includes eighteen such models, brieﬂy described in Table 1. – Only whole-body models with complete analysis of masses for all major segments and divisions are included. – Trunk mass is combined from up to four subsegments for cross-model comparison. – The model closest to the mean (RMSE = 8.0%) was the male data from Pavol et al. [3], a study on an older population. – Large ranges (±30%) gives credence to the approach of subject-speciﬁc modelling. The mean segment masses from the sixteen non-juvenile studies are shown in Figure 1. Figure 1: Average mass per segment for the rela- tive mass models for adults. 7.4 % 46.6 % 3.0 % 1.6 % 0.7 % 11.9 % 4.4 % 1.5 % Figure 2: Relative masses for each segment of each model, excepting models eight and nine, which deviate signiﬁcantly from the others. -40 -30 -20 -10 0 10 20 30 40 Percentage difference from mean HEADNECK RMS = 7.5% 1 2 3 4 5 6 7 10 11 12 13 14 15 16 17 18 TRUNK RMS = 6.3% 1 2 3 4 5 6 7 10 11 12 13 14 15 16 17 18 ARM RMS = 14.6% 1 2 3 45 6 7 10 11 12 13 14 15 16 17 18 FOREARM RMS = 16.0% 1 2 3 4 56 7 10 11 12 13 14 15 16 17 18 HAND RMS = 18.8% 1 2 3 4 5 6 7 10 11 12 13 14 15 16 17 18 THIGH RMS = 13.6% 1 2 3 4 5 6 7 10 11 12 13 14 15 16 17 18 LEG RMS = 7.3% 1 2 3 4 56 7 10 1112 13 14 15 16 1718 FOOT RMS = 18.5% 1 2 3 4 5 6 7 10 11 12 13 14 15 16 17 18 A visualisation of the non-juvenile models is shown in Figure 2, in which segment mass for each is compared to the mean. A deviation of at least ±10% is seen for each segment, indi- cating a large degree of variation in diﬀerent populations and with diﬀerent techniques. Mass–height regression models The repository also includes two comprehen- sive works that deﬁne segment parameters using mass and height as regression variables [16, 17]. These works describe six models, respectively: Chinese F & M, German F & M, and Russian F & M. Each contains data for mass, centroid, and moments of inertia. Figure 3 shows variation in segment mass be- tween models, for three heights per subject. High variability (e.g., head–neck segment for model 2, Chinese M) indicates caution should be used when applying these models outside of their original subject population ranges. Table 1: Relative mass models in the repository. Ref. Name Pop. Method Sex N SDev CoM 1. Harless (1860) Cadaver M 2 2. Braune et al. (1889) Cadaver 3 3. Dempster (1955) Cadaver M 8 ◦ 4. Fujikawa (1963) Japan Cadaver 6 5. Clauser (1969) Cadaver M 13 ◦ ◦ 6. Zatsiorsky et al. (1979) Russia CT F 15 ◦ 7. Zatsiorsky et al. (1979) Young adult CT M 100 ◦ 8. Jensen (1986) 12 yr Photo M 12 9. Jensen (1989) 6 yr Photo M 8 10. Jensen (1989) 18 yr Photo M 8 11. Jensen et al. (1994) Photo F 12 ◦ 12. Jensen et al. (1994) Elderly Photo M 7 ◦ 13. Cheng et al. (2000) China MRI M 8 ◦ ◦ 14. Pavol et al. (2002) Geometric F 50 ◦ ◦ 15. Pavol et al. (2002) Older G	poster
Application of Physics-Informed Neural Network in prediction of chromatographic concentration profiles Filip Rękas1, Marcin Chutkowski2, Krzysztof Kaczmarski2 1 Doctoral School of the Rzeszów University of Technology, Poland 2 Rzeszow University of Technology, Poland The Physics-Informed Neural Network is an emerging technique that has been used for solving various problems involving partial differential equations (PDE). The main concept of the PINN is to reach consistency with the governing physical laws by using training loss function that takes PDEs into account and allows to obtain the results with better accuracy. In this work application of the PINN method to predict the gradient elution profiles of single-component and a binary mixture systems is presented. The dataset for training and testing the PINN was collected by solving the ED column model using the volume method. The following dimensionless form of the Equilibrium Dispersive Model is considered: ௧ ௧ ௘ ௧ ௘ ௧ ଶ ଶ with ௙ ᇱ ௙for ௣ and ௙ ᇱ for ௣ The dimensionless parameters were defined as follows: ௭ ௅ ௧௨ ௅ఌ೐ y ஼ ஼ೝ ௤ ஼ೝ ௦ ௤ೞ ௖ೝ ௨௅ ஽ಽఌ೐ where cr was assumed to be equal to 1 and L is - column length. A scheme of the PINN architecture was illustrated in Fig. 1, where the three input neurons, corresponding to spatiotemporal coordinates (x, ) and injection features ( ) were placed. The injection features are the inlet concentration ( ଴) and the time during the constant concentration is fed into the column ( ௣). On the other hand, the outputs are spatiotemporal fluid-phase concentrations contained in the pores, y(x, ), and concentration in the stationary phase, Q(x, ), which is similar to that proposed by Subraveti et al. [1]. The given outputs are subsequently fed into automatic differentiation layer, which computes partial derivatives. Obtained PDE loss ( ௉஽ா) is further factored into the total loss ( ). Fig. 1 The sketch of Physics-Informed Neural Network structure. INTRODUCTION RESULTS AND DISCUSSION CONCLUSIONS Presented model was implemented in PyTorch framework with the Adam optimizer as the gradient descent based algorithm. The weights were initialized by the Glorot initialization. The fully-connected neural network was made up of 5 hidden layers with 50 neurons in each. Latin hypercube sampling (LHS) was employed to determine the collocation points. To cover the spatiotemporal domain, the number of collocation points was set to 5000. The Hyperbolic tangent was utilized as the activation function. The following formula for the loss function has been proposed: ௉஽ா ூ஼ ஻஼ where corresponds to trainable parameters, in turn ௉஽ாdenotes: ௉஽ா ௙ ௧ ௧ ௘ ௧ ௘ ௧ ଶ ଶ ଶ ே೑ ௜ REFERENCES [1] Subraveti et al., Ind. Eng. Chem. Res. 2023, 62, 5929−5944. Fig. 5 Case study for various injection time: comparison of the PINN predicted and the ED model solution. Fig. 2 Case study for various inlet concentrations: comparison of the PINN predicted and the ED model solution: a) single-compound system, b) binary mixture system. Fig. 3 Case study for various injection time: comparison of the PINN predicted and the ED model solution: a) single-compound system, b) binary mixture system. Fig. 4 Case study for various tg: comparison of the PINN predicted and the ED model solution. a) single-compound system, b) binary mixture system. ACKNOWLEDGMENT This work is supported by: Grant NCN 2022/45/B/ST8/00591 “Analytical and preparative gradient chromatography – advanced modeling” from the Polish National Science Centre The presented concept of using the PINN to predict gradient elution profiles is novel and previously unreported. The effectiveness of the PINN's prediction of elution curves has been verified by comparing them with ED model solutions. The optimization of the efficiency of species separation can be a tedious task that often requires up to several thousand model solutions. It seems that the solution of this problem may be the application of the physics-informed neural networks. Future work	poster
Expert Resources & Support for Data Management Planning Carly Strasser & Patricia Cruse carly.strasser@ucop.edu \| patricia.cruse@ucop.edu In brief: Many funding agencies require data management plans (DMP) as part of grant proposals. The DMPTool helps institutions & researchers to create high-‐quality DMPs that meet funder requirements. The DMPTool collaboration has two grant-‐funded projects underway: 1. Support from the Alfred P. Sloan Foundation to expand functionality and release a second version of the tool 2. Support from the Institute of Museum and Library Services to provide librarians with information to better integrate the DMPTool into their services. What is the DMPTool? Coming soon: DMPTool2 Free step-‐by-‐step web application for creating data management plans for funders Founding partners: DataONE; Digital Curation Centre; Smithsonian Institution; UC Curation Center, California Digital Library; UCLA Library; UC San Diego Libraries; University of Illinois; University of Virginia Libraries General & institution-‐ speciﬁc resources Funder-‐provided information & plan outline Suggested answers & help text Space to answer questions Log in with institution credentials dmptool.org blog.dmptool.org bitbucket.org/dmptool/main @TheDMPTool For administrators: • Better plan template granularity (discipline, funder, question) • Better institution granularity (department, college, lab group, …) • Role-‐based user authorization & access • Enhanced search and browse of plans • Access to metrics for reporting & follow-‐up For plan creators: • DMP life cycle management • Collaborative plan creation • Role-‐based user authorization & access • Better plan templates & resources Plus… • Institutional branding • Open API website blog resources twitter Learn More	poster
0 99% same polymer matrix E.g., Two tyres from different brands 1% difference in additives Remaining sample pyrolysed GC Polymer detected GC (compound separation) MS (compound identification) Thermal desorption of sample Minimal amount of sample needed Direct analysis (no sample preparation required) Better resolution of volatile compounds - including additives Py-GC/MS components: Pyrolyser Cryo-trap GC MS Polymeric product = Polymer matrix + Additives Manufacturers' additive preferences drive chemical variation between brands Analytical technique: Double-shot Pyrolysis-GC/MS Scene compare with Suspect's possession provide link between Suspect Crime scene Polymeric evidence found at a scene: Detects additives MS Compounds condensed at the column using cryo-trap with N then released at the same time 2(liq.) Advantages for forensic analysis Comparison of SS vs DS Supported by: Elution time (min) Relative intensity Figure 1. Total ion chromatograms of tyre rubber (tread). The numbered peaks are examples of the common compounds detected in tyres. Contacts: nieo326@aucklanduni.ac.nz https://www.linkedin.com/in/chloe-ieong/ Results for tyre rubbers Single-shot (SS) Py-GC/MS involves pyrolysis at a set temperature Double-shot (DS) Py-GC/MS involves thermal The DS-TD allows the detection of 3 additional desorption (TD) followed by pyrolysis (Py) additive compounds (Bold in Fig. 1) Isobutylamine: Rubber accelerator Cyclohexanethiol: Chemical intermediate, stabiliser 1,2-dihydro-2,2,4-trimethyl-quinoline: rubber antioxidant References: 1. PubChem. (n.d.). Isobutylamine. Retrieved 22 August 2023, from https://pubchem.ncbi.nlm.nih.gov/compound/6558 2. New Jersey Department of Health and Senior Service (2000) Hazardous substance fact sheet-Cyclohexanethiol. Retrieved 22 August 202, from https://nj.gov/health/eoh/rtkweb/documents/fs/0568.pdf 3. Nowicki, J., Jaroszewska, K., Nowakowska-Bogdan, E., Szmatoła, M., & Iłowska, J. (2018). Synthesis of 2,2,4-trimethyl-1,2-H-dihydroquinoline (Tmq) over selected organosulfonic acid silica catalysts: Selectivity aspects. Molecular Catalysis, 454, 94–103. https://doi.org/10.1016/j.mcat.2018.05.016 4. Lv, Y. (2020). Py-GC/MS analysis of tyre rubber in traffic accident cases. Australian Journal of Forensic Sciences, 52(3), 313–322. https://doi.org/10.1080/00450618.2018.1545869 5. Causin, V. (2015). Polymers on the Crime Scene: Forensic Analysis of Polymeric Trace Evidence. Springer International Publishing. https://doi.org/10.1007/978-3-319-15494-7 6. Canvas (2023). Images of the forensic scientist and car tyre DS-Py 2 3 8 5 6 DS-TD 4 1 7 2 3 5 6 — — SS-Py 2 3 8 5 — 6 — 1: Isobutylamine 2: Benzene 3: Toluene 4: Cyclohexanethiol 5: D-Limonene 6: Benzothiazole 7: 1,2-dihydro-2,2,4- trimethyl-quinoline 8: Styrene Rubber and plastic-like products are composed of polymeric materials. Wads from shotgun DOUBLE THE SHOT, DOUBLE THE GAIN Chloe Ieong Supervised by Sally Coulson and Mickayla Dustin Common Polymeric Products found at Crime Scenes Disposable gloves Rubber smears from tyres Road cone fragments Aim: Increased Discrimination by Analysis of Additives Background a. School of Chemical Sciences, University of Auckland b. The Institute of Environmental Science and Research Ltd Current analytical methods focus on the detection of only the polymer. Based on the prevelance of polymeric products they are frequently found at crime scenes. A technique that detects both polymers and additives will provide better discrimination. (b) (b) (a) 1 2 3 Tracing chemical clues: Additive analysis of polymeric products using Double-Shot Pyrolysis Gas Chromatography/Mass Spectrometry (Py-GC/MS) —	poster
EFFECTS OF LIGHT EXPOSURE ON DAYTIME FUNCTIONNING OF PATIENTS SUFFERING FROM SLEEP DISORDER Illuminating daily struggles related to sleep disorders VAIDA VERHOEF, MSC. SUPERVISOR TEAM: PR.DR.IR. YVONNE DE KORT, PR.DR. SEBASTIAAN OVEREEM, DR.IR. KARIN SMOLDERS HUMAN TECHNOLOGY INTERACTION GROUP_ DEPARTMENT OF INDUSTRIAL ENGINEERING & INNOVATIONS SCIENCES TO START Excessive daytime sleepiness (EDS) is a frequent concern among the clinical and the non-clinical population1,2. Despite its high prevalence, daytime sleepiness remains difficult for people to describe and thus to recognize, diagnosed and treat3,4. Generally defined as a propensity to sleep, sleepiness is often called tiredness, misjudged as fatigue, or described as a lack of alertness, attention or vigilance3,5,6. The overlapping constructs around sleepiness mirror the multitude of assessments methods and contribute to the complexity of sleepiness detection3. Further research is needed in order to improve the detection and monitoring of sleepiness and other sleep related daytime impairments. A PATIENT CENTERED PERSPECTIVE A qualitative study was performed to gain more insight into what patients sufferings from sleep disorders are experiencing and how they describe it. Among 20 patients suffering from narcolepsy or sleep apnoea, we conducted semi-directed interviews centred around the daytime consequences of their diagnosis. The data collected are currently under thematic analysis. First insights: • Patients found it important to discuss and share their daytime struggles. • Different definitions were used to describe sleepiness, fatigue, tiredness and other complaints. • The terms, metaphors and definitions used by patients don’t always correspond to validated subjective measures used by clinicians and researchers. “Walking through syrup” “Fog in my head” “A empty savings account of energy” “A hollowness” “A white light in my head” “Heavy legs” 1Thorpy & Billard, 2011;2Jaussent et al.,2017; 3 Shahid et al. 2010; 4 Slater & Steier, 2012; 5Shen et al., 2006; 6Yun et al., 2015 A FIELD MEASURE OF SLEEPINESS To investigate the validity, sensitivity, and specificity of new and existing metrics of sleepiness for field assessments, we designed a quantitative study combining field and lab measures. We will apply a sleep restriction paradigm among 20 healthy participants. This will enable us to monitor field-levels of sleepiness in response to the cumulative effect of continuous partial sleep restriction, and compare them to commonly-used and validated lab measures. The field assessments of sleepiness include: • Continuous keystroke monitoring • Self-reports (KSS, SSS, VAS) using the experience sampling method (10 short questionnaires per day) • Continuous skin temperature recording and Actiwatch monitoring • Daily questionnaires (ESS, PROMIS) and performance task (PVT) A FUTURE IN DAYLIGHT Insights into the patients’ experiences and into field measures of sleepiness will enable us to pursue the main aim of this project: Investigating how daytime light exposure might benefit patients suffering from sleep disorders. Future studies will evaluate how the field measures respond to patient’s experiences and how they might be affected by daylight and manipulated light exposure patterns. This endeavour is part of the LIGHTCAP7 consortium, a European project that focuses on the study of both image and non-image forming pathways of light. In particular, this project is part of the second work package, that investigates the effects of light on human’s cognition, attention and perception, in both laboratory and field studies. 7LIGHTCAP This research is part of the European Training Network LIGHTCAP (project number 860613) supported by the Marie Skłodowska-Curie actions framework H2020-MSCA-ITN-2019. Figure1. Overview of the experiment protocol	poster
Methods Results CO_AutoCorr DN_CompareKSFit FC_LocalSimple FC_Surprise IN_AutoMutualInfoStats NL_BoxCorrDim NL_TSTL PH_Walker SB_TransitionpAlphabet SC_FluctAnal ST_LocalExtrema SY_KPSStest TSTL_localdensity Prediction of time samples Self-similarity Angus Leung, Ahmed Mahmoud, Travis Jeans, Ben Fulcher, Bruno van Swinderen, Naotsugu Tsuchiya angus.leung@monash.edu Background • The neural mechanisms of consciousness remain elusive • Proposed mechanisms are derived from consciousness markers • BUT current consciousness markers have issues: ◦Identified markers have no principled link with consciousness ◦Bias towards time-series features which are visually identifiable ◦Bias towards specific analyis methods from researcher background ◦Bias towards specific data sets • NEW approach: agnostically evaluate as many analysis methods as candidate consciousness markers ◦Made possible by highly comparative time-series analysis [1] ◦hctsa provides a library of >7,000 univariate time-series features from various research fields ◦Evaluate generalisation of candidate markers to multiple, wide-ranging inde- pendent datasets 0.4 0.5 0.6 0.7 discovery accuracy 0.35 0.4 0.45 0.5 0.55 0.6 evaluation accuracy sig. in all flies 0.4 0.5 0.6 0.7 0.8 0.9 discovery consistency 0.35 0.4 0.45 0.5 0.55 0.6 0.65 0.7 ApEn EN_MS_LZcomplexity EN_PermEn EN_SampEn SP_Summaries evaluation consistency 100µm ch1 ch15 x13 discovery flies (D) x49 evaluation flies (E) V 2.25s D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12 D13 E14 E15 D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12 D13 E1 E2 0 0.5 1 norm. value anest wake 0 1 D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12 D13 -1 1 E1 E2 0 1 W-A wake - anest anest wake e.g. StatAvl250 e.g. MD_rawHRVmeas_SD2 DN_FitKernelSmooth DN_Mean DN_Moments DN_Spread MD_rawHRVmeas ch6 ch6 ch6 ch1 ch1 ch1 ch1 ch1 ch1 ch1 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch4 ch4 ch4 ch4 ch4 ch4 ch4 ch4 ch4 ch3 ch9 ch9 ch9 ch9 ch9 ch9 ch9 ch8 ch8 ch4 ch3 ch1 ch9 Top 40 features Variability of time samples Variability of kernel-smoothed samples 1000 2000 3000 4000 5000 6000 feature discovery multidose8 multidose4 singledose sleep -0.6 -0.4 -0.2 0 0.2 0.4 0.6 Δ value 1000 2000 3000 4000 5000 6000 feature train W multidose8 W singledose W sleep W train A multidose8 A singledose A sleep S fly 0 0.5 1 scaled value 1.5 • hctsa values for each fly (channel, epoch averaged) • Differences (wake - anaesthesia) in hctsa values for each fly (channel, epoch-pair averaged) • Features related to previously identified markers (coloured x’s; e.g. spectral power, SP) fail to strongly generalise to evaluation flies • Top feature, NL_BoxCorrDim_50_ac_5_minr13, related to fractal geometry • Direction of effect of anaesthesia/sleep is consistent for many features, including those which did not strongly generalise (e.g. SP) • Failure to strongly generalise due to high inter-fly and -dataset variability • Only 47 features strongly generalised across all flies, at centre of fly brain • Features related to self-similarity and -prediction measures • 5280 features across whole fly brain weakly generalise across all flies • Top features related to variance measures strong generalisation weak generalisation 500 1000 1500 2000 t (ms) -2 -1 0 wake unawake discovery multidose8 multidose4 singledose sleep NL_BoxCorrDim_50_ac_5_minr13 log( +12.2) discovery multidose8 multidose4 singledose sleep 0.2 0.4 0.6 0.8 SP_Summaries_fft_area_5_1 Summary • Apply hctsa to neurophysiological recordings obtained during wakefulness and loss of consciousness, using registered report framework • Stage 1 for each feature, train and evaluate a classifier on a discovery dataset: ◦N = 13 flies (D; wake / isoflurane anaesthesia; cross-validation) • Stage 2 for each feature, evaluate generalisation of trained classifier across indi- viduals to independent, previously blinded, evaluation datasets (strong generali- sation) ◦N = 8 + 4 + 18 + 19 = 49 flies (E; wake / isoflurane aneasthesia / sleep) • Stage 2 for each feature, evaluate the co	poster
Predicting Clinical Deteriorations using Wearable Sensors Peter.Charlton@kcl.ac.uk Peter H Charlton 12, T Bonnici 1, L Tarassenko 2, PJ Watkinson 3, DA Clifton 2, R Beale 1, J Alastruey 1 1 Faculty of Life Sciences and Medicine, King’s College London, UK; 2 Department of Engineering Science, University of Oxford, UK; 3 Oxford University Hospitals NHS Foundation Trust, UK Clinical Problem Aims Monitoring breathing rate unobtrusively Predicting deteriorations using wearable sensors Next Steps Hospital patients are at risk of clinical deteriorations such as heart attacks and strokes. Early signs of deteriorations can be identified from clinical measurements such as heart rate and blood pressure. These are measured by hand every 4-6 hours. It may be possible to monitor patients continuously using wearable sensors. Breathing rate is a key marker of deteriorations, but it is difficult to measure electronically. 1. To develop a technique for monitoring breathing rate unobtrusively using wearable sensors. 2. To assess whether wearable sensors can be used to reliably predict deteriorations using this technique. Wearable sensors gave advanced warning of physiological changes hours before routine practice Wearable sensors predicted deteriorations with similar accuracy to routine practice AUROCs: 0.79 0.78 AUROCs: 0.69 0.73 Many wearable sensors monitor the heart using the ECG signal, which is influenced by breathing. Errors (in breaths per minute) 0 -10 10 -5 5 By hand Intensive care monitor A novel technique was developed to estimate breathing rate from the ECG. Laboratory tests showed that it was at least as precise as existing methods. New technique cardiac arrest normal range The novel technique was able to identify elevated breathing rates (BRs) in the hours preceding a cardiac arrest, when routine practice did not. ECG (BW) Time [s] 0 2 4 6 8 10 ECG (AM) ECG Acknowledgments This work was supported by the UK EPSRC (Grant EP/H019944/1), the NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London, the NIHR Oxford Biomedical Research Centre Programme, the Oxford and King's College London Centres of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under grant no. WT88877/Z/09/Z and grant no. WT088641/Z/09/Z, a Royal Academy of Engineering (RAEng) Research Fellowship awarded to DAC, and an EPSRC Challenge Award to DAC. The views expressed are those of the authors and not necessarily those of the EPSRC, NHS, NIHR, Department of Health, Wellcome Trust, or RAEng. Smart watches routinely measure a signal which is influenced by both the heart and blood vessels. 0 1 2 3 4 5 6 7 8 9 10 Time [s] PPG The signal is indicative of cardiovascular health, providing opportunity to predict deteriorations in the wider population. Atrial fibrillation is an arrhythmia affecting 25% of patients after heart surgery. Here, the wearable sensor identified an increase in heart rate, indicating atrial fibrillation, prompting treatment. Here, the wearable sensor detected a drop in oxygen levels hours before routine practice, prompting earlier initiation of oxygen therapy to maintain healthy oxygen levels. A system was designed to predict deteriorations from wearable sensor data. Its performance was assessed in a clinical trial of 184 patients. Its predictions were of similar accuracy to those made in routine practice. relaxed stressed Detecting serious deteriorations Detecting minor deteriorations Source: Charlton, Peter H. (2016, July). The Processes and Benefits of Sharing Clinical Data. Zenodo. http://doi.org/10.5281/zenodo.166546 Source: Peter H Charlton. (2016). Wireless Wrist Pulse Oximeter Photo. Zenodo. http://doi.org/10.5281/zenodo.569814 Adapted from:: Charlton, P.H. et al., 2017. Extraction of respiratory signals from the electrocardiogram and photoplethysmogram: technical and physiological determinants. Physiological Measurement, 38(5), pp.669–90. DOI: 10.1088/1361-6	poster
REDUCED BAYESIAN INVERSION Reducing Bayesian Inverse Problems with Balanced Truncation Christian Himpe (christian.himpe@uni-muenster.de) Mario Ohlberger (mario.ohlberger@uni-muenster.de) Synopsis Combined reduction enables the concurrent reduction of state and parameter space dimensions, which accelerates the integration. Here the reduction of state space is based upon experimental observations which are balanced against a models output. The parameter space is reduced based on the identiﬁability inside the model. In a Bayesian inversion setting with undetermined posterior parameter distributions, the estimation duration can be signiﬁcantly shortened. Balanced Truncation Control Systems As an underlying model to the (Bayesian) inversion, control systems are considered: ˙x = f (x, u, θ) y = g(x, u, θ). First, to introduce balanced truncation the focus is narrowed to linear control systems: ˙x = Ax + Bu y = Cx. The empirical gramians are based on the same approach, yet allow nonlinear and thus more general control systems. Controllability + Observability Controllability quantiﬁes how well a state can be driven by input or control. The controllability gramian WC characterizes the controllability of a linear system and is computed as the smallest semi-positive deﬁnite solution of the Lyapunov equation: AWC + WCAT = −BBT. Observability quantiﬁes how well a change in state is reﬂected by the outputs. The observability gramian WO characterizes the observability of a linear system and is computed as the smallest semi-positive deﬁnite solution of the Lyapunov equation: ATWO + WOA = −C TC. Balanced Truncation The Hankel operator maps past inputs to future outputs via the impulse response: H(t) = Z 0 −∞ CeA(t−τ)Bu(τ)dτ. The singular values of the Hankel operator σi indicate the importance of the associated state to the system dynamics. To determine the least controllable and least observable states, the controllability and observability gramians are balanced by a similarity transformation that balances the systems components (A, B, C). Truncating the balancing transformation U, V with VWCV T = UTWOU = σi, the reduced linear system is given by (VAU, VB, CU). Empirical Gramians Empirical Controllability Gramian The empirical controllability gramian ([1]) is computed by averaging the outer product of state time-series centered around the steady state ¯x: WC = 1 \|Qu\|\|Ru\| \|Qu\| X h=1 \|Ru\| X i=1 m X j=1 1 c2 h Z ∞ 0 Ψhij(t)dt Ψhij(t) = (xhij(t) −¯x)(xhij(t) −¯x)∗∈Rn×n. xhij is a state time-series generated using the perturbed input uhij(t) = chSieju(t) + ¯u based on the perturbation sets: Eu = {ei ∈Rj; ∥ei∥= 1; eiej̸=i = 0; i = 1, . . . , m} Ru = {Si ∈Rj×j; S∗ i Si = 1; i = 1, . . . , s} Qu = {ci ∈R; ci > 0; i = 1, . . . , q}. For linear systems the empirical controllability gramian equals the classic controllability gramian, but since being based on snapshots extends also to nonlinear systems! Empirical Observability Gramian The empirical observability gramian ([1]) is computed by averaging the inner product of output time-series centered around the steady state output ¯y: WO = 1 \|Qx\|\|Rx\| \|Qx\| X k=1 \|Rx\| X l=1 1 d2 k Tl Z ∞ 0 Ψkl(t)dt T ∗ l Ψkl ab = (ykla(t) −¯y)∗(yklb(t) −¯y) ∈R. ykla is an output time-series generated using the perturbed initial state xkla 0 = dkSlfa + ¯x based on the perturbation sets: Ex = {fi ∈Rn; ∥fi∥= 1; fifj̸=i = 0; i = 1, . . . , n} Rx = {Ti ∈Rn×n; T ∗ i Ti = 1; i = 1, . . . , t} Qx = {di ∈R; di > 0; i = 1, . . . , r}. For linear systems the empirical observability gramian equals the classic observability gramian, but since being based on snapshots extends also to nonlinear systems! Empirical Identiﬁability Gramian A system can be augmented by a constant state for each parameter with the parameter value as initial state: ˙xa = ˙x ˙θ = f (x, u, θ) 0 xa(0) = x0 θ . Then the empirical identiﬁability gramian ([2]) is given as the empirical observability gramian of this augmented system: WO,a = WO WM W ∗ M WP .	poster
R. Silvotti, INAF-Osservatorio Astrofisico di Torino Single vs binary hot subdwarfs: towards a 200-pc volume-limited complete sample Abstract From current statistics, based on mag-limited samples, 35% of sdO/B hot subdwarfs are in close binaries with M-dwarf/WD companions, ~30% are in wide binaries with F/G/K MS stars, 35% are apparently singles. However, without a companion it is hard to explain the huge mass loss near the RGB tip needed to form an sdB star. The presence of a substellar companion, difficult to detect, is a possibility. The goal of this project is to shed light on the formation mechanisms of single sdO/B stars by searching for binary signatures on a small but complete 200-pc volume-limited sample using different data/methods: TESS light curves, Gaia spectra, SEDs, and precise RVs from Harps/Harps-N spectra. Introduction, selection of the targets, data/methods The target list was extracted from the catalog of Culpan+2022 (A&A 662, A40), based on Gaia EDR3, which was complete up to about 250 pc as we can see from Fig.1. As a first step we considered the sample within 200 pc (20 stars) and later we added one missing star from the more recent 500-pc volume-limited sample by Dawson+2024 (A&A 686, A25). These 21 stars are listed in Table 1. We can see that 2 are in tight binaries with a WD, 1 is in a tight binary with an M-dwarf, and 3 have MS companions in larger orbits. Among the remaining 15 stars, 3 show tiny periodic variations in their TESS light curves, and one shows irregular photometric variations. The objective of this project is to verify how many of these stars are truly single, moving down as much as possible the detection limit of a faint, low-mass companion. The HARPS and HARPS-N instruments are ideal to obtain a homogeneous set of high- resolution spectra in both hemispheres, from which accurate radial velocities (RVs) can be derived. Using the cross correlation function (CCF) on 100-200 metal absorption lines (up to 500 in one case), we can reach typical errors of 100-200 m/s (Fig.2). Preliminary results and short discussion At least 6 out of 15 apparently single sdO/B stars within 200 pc do not show TESS photometric variations nor RV variations within measurement limits. Three stars show short-period variations in their TESS light curves, presumably due to a companion, which may or may not be confirmed by ongoing RV measurements (an example is given in Fig.3). One star shows irregular photometric variations in its TESS light curve and it should be observed soon with HARPS@3.6m. Two stars (PG0342+026 and PG0044+097) are known g-mode pulsators (Sahoo+2020, MNRAS 495, 2844; Silvotti+2020, MNRAS 489, 4791) and for this reason their RV data are not shown in Fig.2. These 2 articles report some limits on the presence of a companion, however the RV variations caused by g-mode pulsations make it more difficult to set reliable strong limits. Finally, 3 stars do not have yet RV measurements: one has only 1 spectrum but should be reobserved this summer with HARPS-N@TNG, another should be observed this autumn with HARPS@3.6m, the third does not yet have scheduled observations. A few stars show a weak flux excess near 400 nm in their Gaia BP/RP XP spectrum that might be due to a WD companion but further analyses (and additional RV data) are needed to confirm this finding. Fig.2. Radial velocities obtained from Harps-N spectra using the CCF method with 4 masks, corresponding to 4 different models: 25000 K He-poor, 35000 K He-poor, 38000 K He-rich, 50000 K, He-rich. The masks were built from 4 line lists kindly provided by Matti Dorsch. Fig.3. Upper panel: TESS Fourier spectrum of one of the targets showing periodic photometric variations (top) and phase diagram of the RV measurements folded onto the main photometric period at 0.315 d (bottom). These RV measurements are not yet sufficient to confirm the presence of a low-mass companion (they are compatible with constant RVs) and more data will be needed. Lower p	poster
•s # 14 Group B SYNERGISTIC MONITORING OF MULTI-SENSOR AND MULTIPLE OCEAN PARAMETERS: SST, SALINITY, HEIGHT, WIND AND COLOR Prasanjit Dash1,2, Paul DiGiacomo1, Veronica Lance1,3, Heng Gu1,4 , Michael Soracco1,4 1NOAA STAR SOCD, College Park, MD, USA 2CIRA, Colorado State Univ ; 3CICS, Univ of MD ; 4RIVA Solutions, Inc. Fig. 1: A monitoring framework for satellite-based all ocean parameters for the CoastWatch/OceanWatch program of NOAA/STAR/SOCD. Monitoring is performed in Global and 19 additional Regions of Interest (RoI) for simultaneous analyses of SST, SSS, SSH, SSW and OC from different sensors. The objective is to comprehensively evaluate the products and steps beyond conventional validation approaches in an interactive web-interface useful for users, producers and scientists. Most of the diagnostics provided online can also be numerically (data in ASCII) accessed by the web-users. The users can interactively perform a variety of operations on time series plots and export the output to raster images. Wish to see a first-hand demo? Catch me during the breaks. 2. Diagnostics in OceanWatch Monitor 3. A future Ocean Viewer: The SOCD OceanView (OV) mock-up The 20th International GHRSST Science Team Meeting (GHRSST XX) – ESA ESRIN, Frascati, Italy – 3rd to 7th June 2019. Contact: prasanjit.dash@noaa.gov • This OceanWatch Monitor (OM) is a continuing effort to set a comprehensive monitoring tool for NOAA SOCD CoastWatch/OceanWatch products. The initial list of EDRs include: SST, Salinity, Surface height, Surface winds and Ocean Color. All diagnostics are made available online. • Currently, products are compared against Level-4 fields and model output. Routine validation against in situ data will be undertaken in the future. • A modern visualization tool is being conceptualized for a year 2021 release or earlier. 4. Summary and Outlook • P. Dash, S. Baker-Yeboah, V. P. Lance, S. Ramachandran, H Gu, P. DiGiacomo (2018), Towards an enterprise monitor for simultaneous monitoring of multiple ocean parameters: SST, SALINITY, HEIGHT, WIND AND COLOR, The 19th GHRSST Science Team Meeting, 4-8 June, 2018, EUMETSAT HQ, Darmstadt, Germany. • P. Dash, A. Ignatov, Y. Kihai, J. Sapper (2010), The SST Quality Monitor (SQUAM) , J. of Atm. & Oceanic Tech, 27(11), 1899-1917. https://www.star.nesdis.noaa.gov/sod/sst/squam/ References Collaborating partners and product team leads at NOAA NESDIS STAR SOCD Acknowledgments •The OceanWatch Monitor (OM) is designed for monitoring and validation of satellite-based CoastWatch/OceanWatch (CW/OW) ocean products and make the diagnostics available at: https://www.star.nesdis.noaa.gov/socd/om/. •Currently, the monitor is a standalone system but serves as a companion site to the NOAA CW/OW main web-page: https://coastwatch.noaa.gov/. In the future, efforts will be made to integrate the most relevant features of this monitor into the CoastWatch web-interface. •This monitor aims at providing an easy way to the CW/OW users to assess the state of the available products under one URL. The scope includes: • Assisting users/producers to remain aware of the state of the data they use/generate (data monitoring) • Providing a framework for synergistic ocean studies (scientific application), and • Bridging the gap between the satellite community and the modeling community (retrieval and model intercomparison). •The OM performs both Global and pre-defined Regional analyses. Currently, 20 oceanic regions of interest (ROI) are pre-selected (Fig. 1), and this can be expanded as required. •The current capability includes monitoring of five different environmental data records (EDRs): Ocean Color (OC) Chlorophyll-a, Sea Surface Height (SSH), Sea Surface Salinity (SSS), Sea Surface Temperature (SST) and Sea Surface Wind (SSW). The system is Scalable and Flexible for including other types of EDR and more product types for a given EDR. For example, considerations are being made at the NOAA STAR Satellite Oceanography and Climatolog	poster
The role of adult service websites in addressing modern slavery Professor Teela Sanders and Dr Rachel Keighley School of Criminology, University of Leicester Executive Summary: • The landscape where modern slavery and sexual exploitation takes place has changed with the onset of digital technologies dominating the organisation of the commercial sex industry. • Adult Service Websites (ASWs), where most sexual services are advertised, negotiated and facilitated in the UK, are a space where exploiters can manipulate, entrap, coerce, and force individuals into selling sexual services. • The role of ASWs in facilitating offending behaviour is complicated and unregulated as national intelligence services try to understand routes to trafficking, the police work to identify victims and target offenders, and first responders deliver interventions to victims of sexual exploitation. • Researchers from the University of Leicester, in partnership with the National Crime Agency, National Police Chief's Council, and the Unseen investigated what role ASWs can play in preventing human trafficking and sexual exploitation in the UK, and their role in wider policies and laws on this issue. Methods: A mixed methods approach formed the framework of the research design. We chose this approach so the project could generate a unique body of evidence that reaches beyond existing data or government consultation: • An online questionnaire for providers and consumers using ASWs (n=142) • In-depth interviews with ASW staff (n=5) • Interviews with police (n=30 across 23 forces in England and Wales) and practitioners (n=13) involved with ASWs engagement and enforcement • Analysis of contemporary historical records and data from the last five years from the Unseen Helpline to identify knowledge on the role of ASWs in reported cases of modern slavery. Survivor involvement: Embedded into the project was ethical survivor involvement in peer research. Working alongside Unseen, the peers were involved through participation in the advisory group, instrument design, implementation, analysis, and the dissemination phase. We provided capacity building through a bespoke training package of Action Learning Sets. The regulation of ASWs: The interviews explored the current regulatory practices of ASWs and their responsibilities in preventing MSHT and how this could be improved with forthcoming UK legislation (UK Online Safety Bill): • Pop-up and easy to use reporting mechanisms. • Dedicated support pages and customer care/community teams. • ASW working groups with the NCA and police and partnerships with NGOs and sex worker support groups and operationalising feedback. • Human and AI moderation of content. • Multi-layered verification measures. • Proactive removal of illegal content to protect those selling sex. • Proactive reporting cases to the police and data sharing/complete compliance with investigations. ‘We are aware that ASWs remain a significant enabler within the sexual exploitation, modern slavery, and human trafficking threat, and we strongly believe that any business operating in this space has a responsibility to understand the risks involved, and to mitigate those risks to the best of its abilities.’ (ASW Operator) 4% 6% 2% 2% 3% 83% Coercion (Threats, blackmail, etc.) False promises or statements Familial Intimate partner/marriage proposition Job offer/advertisement Unknown Figure: The Recruitment Tactics used by potential exploiters to abuse and exploit individuals for sex on ASWs ‘I think if they’re going to exist, they have a responsibility in prevention. I won't make a comment on whether or not they exist, they exist, so I think therefore they have a responsibility in prevention. It probably fundamentally doesn’t work well for their business model to be a huge advocate for prevention. I think that’s the difficulty.’ (Intelligence Officer and Head of Operations, National Charity) https://doi.org/10.25392/leicester.data.23629005	poster
OpenSourcePrinciplesUtilizedbytheCERESEdition5Level-3Framework Thomas.N.Hillyer@nasa.gov, ADNET Joshua.C.Wilkins@nasa.gov, ADNET 0. Abstract The Clouds and the Earth’s Radiant Energy System (CERES) Science Team integrates and fuses observations from six CERES instruments aboard the Terra, Aqua, S-NPP, and NOAA-20 missions with data from twenty-five geostationary imagers, in creating a nearly 25-year, ongoing record of the Earth’s radiation budget. In preparation for the next version of CERES data products, the team has been exploring software development methods leveraging open-source principles and software to streamline data product configuration and algorithm implementation. This effort will provide robust software for production while maintaining greater flexibility for the algorithm developers to explore new science. Developers on the CERES Level 3 products have created a framework allowing greater modularization and flexibility to design and configure CERES Level 3 products while reducing development time. The framework leverages open data formats to configure data variables and attributes within the product, declare tolerances for input validation, select resolution and binning schemes, and allow algorithm selection at runtime without requiring recompilation of the product generator. The framework incorporates means to perform unit and integration testing allowing more rapid feedback to the science team. The framework has been used for one current CERES data product and has demonstrated promise for upcoming products in development. 1. Requirements The CERES Level 3 working group lead’s goals for Edition 5 framework are the following improvements over Edition 4: • Modular and Flexible – Single Purpose Algorithms and Functions – Minimal Disruption When Swapping Algorithms • Configurable – Minimize Need for Constant Source Code Changes – Favor Descriptive and Structured Configuration Files Where Possible – Enable/Disable Scientific Parameters as Needed – Easily Change Processing Modes ∗Binning - how footprints are assembled ∗Gridding · 1◦, 1/2◦, etc. · equal angle or equal area gridding • Rapid Development and Analysis – Adjustable Granularity ∗Daily ∗Monthly – Quick Tests or Long-Term Analysis 2. Programming Languages Part of the updated Edition 5 framework in- volves extensive refactoring of the existing Edition 4 Fortran 90 codebase to take greater advantage of object oriented facilities in modern languages. • C++-17 TISA Gridding • Fortran 2018 TISA Averaging 3. Improved Unit Testing Increased modularization allows easier incorporation of unit testing for Level 3 software. CERES Edition 5 framework is using the open source doctest frame- work allowing tests to be written into production code. https://github.com/doctest/doctest 4. JSON-based Product Configuration JSON-based configuration files are used to define the struc- ture of data products, valid ranges for input and output prod- ucts, and various attributes to be included with the final prod- uct. Many libraries exist allowing JSON-based configuration parameters to be shared across both product generators and programming languages. 5. JSON Properties Used in Code The framework makes use of the following open source C++ JSON library hosted on Github: https://github.com/nlohmann/json 6. Proof of Concept (CRS1deg-Hour) The CERES Edition 4 CRS1deg-Hour data product was se- lected to be a proof of concept for exercising the Edition 5 Level 3 framework. The CRS1deg-Hour product provides hourly CERES Clouds and Radiative Swath (CRS) longwave and shortwave computed vertical flux profiles and cloud prop- erties spatially gridded into 1◦-regions. The CRS1deg-Hour PGE was recently delivered to produc- tion and uses the Edition 5 framework (using Edition 4 CRS data) and creates a user-friendly, gridded NetCDF-4 data product. Using the framework, it was easy for the team to use the JSON configuration files to define key features and settings to use at runtime, declare toleranc	poster
DE German Reproducibility Network The German Reproducibility Network (GRN) What is it and why is it worth joining? What is the GRN? • Peer-led cross-disciplinary consortium, which aims to foster reproducibility, trustworthiness and openess of scientific research on a national level • Activities: – Promotion of training and education on open science practices – Bringing stakeholders together – Various exchange formats (e.g. virtual brainstorming events, workshops) • Founded on February 1, 2021 • 42 members (as of July 2023) – 33 local reproducibility initiatives – 5 research institutions – 2 academic societies Why is it worth joining? • Signal institutional commitment to open science and reproducible research • Initiate strategic discussion on open science and reproducibility of research at the institution. • Collaborate with local reproducibility initiatives • Support researchers from your own institution with materials from network partners • Take advantage of a wide range of exchange and networking opportunities How can we join the GRN? • Check conditions for membership • How to join – For reproducibility initiatives: Informal application – For research institutions: Development of a research improvement strategy & create a senior academic role with responsibility for promoting quality, robustness and transparency of research + Memorandum of Understanding – For academic societies: Memorandum of Understanding • More information: https://reproducibilitynetwork.de/join Keep in touch https://reproducibilitynetwork.de @GermanRepro@mastodon.world @GermanRepro info@reproducibilitynetwork.de Subscribe to our mailing list: grn@lists.lrz.de Antonia C. Schrader, Helmholtz Open Science Office https://orcid.org/0000-0001-7080-634X David Philip Morgan, University of Mannheim https://orcid.org/0000-0001-8213-451X Philipp Zumstein, University of Mannheim https://orcid.org/0000-0002-6485-9434 This work, excluding logos, is licensed under a Creative Commons Attribution 4.0 International. https://creativecommons.org/licenses/by/4.0/deed.de Bremen Lübeck Rostock Potsdam Münster Bochum Göttingen Leipzig Dresden Bayreuth Mannheim Tübingen Munich Landau in der Pfalz Frankfurt am Main Jena Bonn Berlin Kiel Würzburg	poster
INTRODUCTION Over decades, smoking has been identified as one of the most preventable public health problems. However, rate of reduction in smoking prevalence has been relatively stagnant over the past decade. In parallel to the WHO Framework Convention on Tobacco Control (WHO FCTC) initiatives, quit smoking clinics (QSCs) have been established in various health clinics across Malaysia to proactively promote and aid smoking cessation amongst patients especially those with other comorbidities. The use of certain pharmacotherapy has been impeded by the cost in view of the higher pricing even though it may be more effective in aiding one to kick smoking habits. As such, it is pivotal for research to be conducted to evaluate both the efficacy and the cost of the interventions to determine the more cost-effective treatment regime. A retrospective study was conducted in Kuala Lumpur Health Clinic (KKKL) where medical records of patients who attended the QSC from January 2018 to December 2018 were evaluated. Cost estimation was done via macro and micro costing. The primary aim of this study was to evaluate the cost-effectiveness of combination therapy against monotherapy in smoking cessation program, hence providing evidence of the most effective intervention in the local setting. To predict the relationship between monotherapy and combination therapy on successful quitting, the treatment regimens were regressed on the outcome variables with a statistical significance set at a level of p<0.05. A total of 213 health records were evaluated and 94.8% were mainly male and 73.7% Malays. Majority of the samples (124 participants) were provided with combined therapy (nicotine and varenicline) and 89 participants were given monotherapy (nicotine only). It was found that none of the sociodemographic variables affects the outcome of quitting except for those with higher education level having significantly higher odds of quitting compared to those in the lower education level. Overall combination therapy was more effective in aiding smoking cessation (74.2% successful rate) compared to monotherapy (34.8% successful rate). Cost of treatment per patient for combination therapy was RM1,028.25, whereas for monotherapy was RM819.13. Cost- effectiveness ratio revealed that combination therapy is more cost-effective compared to monotherapy which cost per one percent successful rate was RM1,718 and RM2,095 respectively. In conclusion, combination therapy is more cost-effective compared to monotherapy in smoking cessation program conducted in Kuala Lumpur Health Clinic. Therefore, combination therapy should be the preferred choice for smoker to quit smoking compared to monotherapy. METHODOLOGY The study population consisted of 213 patients who had attended the smoking cessation clinic at KKKL in 2018. The general characteristics of the study population were mainly male dominated (94.8%) and Malays (73.7%). This was consistent with the current demographics of smokers in Malaysia. The mean ages of the smokers were similar in both the monotherapy and combination therapy arms, mainly aged above 40 years old. Treatment Outcome Analysis Treatment outcome was assessed by the number of successful smoking cessation as defined by smoke free for at least six months Treatment modalities and treatment outcome (N=213) Successful Not Successful Monotherapy 31 58 Combination Therapy 92 32 Total 123 90 Out of the 213 registered patients on pharmacotherapy, approximately two third of the patients have at least one comorbidity. Over one-third of them had either hypertension or diabetes with merely 3% of them have tuberculosis. Nevertheless, descriptive characteristics of the study population that was reported cessation outcome showed that none of the baseline characteristics have a clear-cut implication on success rate of smoking cessation. From the dataset, presence of different types of comorbidities did not statistically change the proportion of quit rate. Further ana	poster
In the Wild Fast!! Real-time plotting + interactivity Pure python: Native Python data structures & NumPy arrays, no C++ required Extensive: Supports images, scatterplots, lines, 3D graphs, meshes, colormaps, parameter configs, custom graphics, and more Integratable: Seamlessly fits into any PyQt/PySide application Summary Legend • Non-linear transformations • Multiple vertical and horizontal scales/axes on the same plot • More CuPy & Numba integration • Support being a plot backend for Pandas Future Work PyQtGraph - High Performance Visualization for All Platforms Ognyan Moore, Nathan Jessurun, Martin Chase, Nils Nemitz, Luke Campagnola SciPy 2023 A – Antenna Array Analysis – https://github.com/rookiepeng/antenna-array-analysis B – argos – https://github.com/titusjan/argos C – ndscope – https://git.ligo.org/cds/software/ndscope D – iris – https://github.com/LaurentRDC/iris-ued E – barney – https://github.com/j9ac9k/barney F – SO2 – Alaska Volcano Observatory G – S3A – https://gitlab.com/s3a/s3a H – neurotic – https://neurotic.readthedocs.io I – xrayrecon – https://gitlab.com/ficsresearch/xrayrecon J – EnMAP-Box – https://enmap-box.readthedocs.io K – joulescope – www.joulescope.com/ L – ephyviewer – https://ephyviewer.readthedocs.io See more at https://github.com/pyqtgraph/pyqtgraph#used-by PyQtGraph is a plotting library that integrates NumPy and the Qt framework, allowing users to develop scientific applications where high performance, interactivity, and cross-platform compatibility are a given. It is:	poster
Applicability of breast cancer 313 Polygenic Risk Score (PRS313) in the Spanish region of Navarra Edurne Urrutia-Lafuente1, Ane Miren Sagardia Fernández1, Maria Miranda Pérez1, David Cobos Hermosa1, Óscar Teijido1, David Gómez-Cabrero1#, Ángel Alonso1,2#. 1. Navarrabiomed - IdiSNA - HUN, Genomic Medicine Unit, Pamplona, Spain. 2. Hospital Universitario De Navarra, Genetics Department, Pamplona, Spain. AIM METHODS 2. Individual assessment: · Exploratory analysis · Differential expression · Functional enrichment 1. Systematic review of public repositories and selection of transcriptomic studies: RNA-seq and microarrays. 3. Meta-analysis and functional enrichment 3.1. Synthesis of the functional enrichment The aim of this study was to identify and understand the molecular mechanisms underlying sex-based differences in RA. SCREENING INCLUDED SEARCH #1: GEO 172 records 200 records after removing duplicates 41 full-text articles assessed for eligibility 6 STUDIES INCLUDED in the individual assessment 5 STUDIES INCLUDED in the meta-analysis Figure 1. PRISMA diagram that represents the workflow of the systematic review. Meta-analysis and functional enrichment 10 genes, 90 biological processes and 11 KEGG pathways were identified as significantly sex- dependent. The enrichment results suggest a higher immune system activity and a larger presence of energy precursors in female RA patients, among others. Male RA patients, in contrast, showed an overrepresentation of terms related to protein biosynthesis and negative regulation of osteoblasts (Figures 2, 3). Data analysis workflow Comparison GOslim terms Figure 2. Pyramid of GOslim terms. The horizontal axis shows the number of GO terms associated to each GOslim term. Terms overrepresented in males are displayed in red, and those overrepresented in females, in blue. RA - CONTROL VS RA - CONTROL SEARCH #2: ArrayExpress 78 records Polygenic risk scores (PRS) have demonstrated their potential to predict the probability of developing cancer. This allows risk stratification and thus improved screening programmes. Among them, PRS313 is the best-performing breast cancer PRS for European-ancestry women.1 The NAGENMx project aims to provide the necessary evidence to implement a personalized breast cancer-screening program in Navarra based on this PRS. Therefore, prior validation in our population is essential to ensure an accurate stratification. The goal of this study was to evaluate the applicability of breast cancer PRS313 in the Spanish region of Navarre. METHODS REFERENCES 1. Mavaddat, et al. (2019). Polygenic risk scores for prediction of breast cancer and breast cancer subtypes. The American Journal of Human Genetics, 104(1), 21-34. 2. Collister, J. A., Liu, X., & Clifton, L. (2022). Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists. Frontiers in Genetics, 13, 105. 3. Choi, S. W., Mak, T. S. H., & O’Reilly, P. F. (2020). Tutorial: a guide to performing polygenic risk score analyses. Nature protocols, 15(9), 2759-2772. CONCLUSIONS Samples Data analysis workflow 1. Sample selection: 2. Exploratory data analysis (EDA): High risk (Hereditary breast cancer criteria) 3. PRS evaluation2,3 INTRODUCTION RESULTS RESULTS • Missing SNPs pose a major limitation when applying existing PRSs to new populations. • The greater separation between the control and moderate-risk groups might suggest a higher polygenic burden in the latter, while the high-risk group with strong family history could be explained by rare mutations not included in the PRS313. However, further exploration is still needed. • Ultimately, applying existing PRSs in different populations is challenging and requires standard guidelines for their evaluation and for dealing with missing data. AIM Moderate risk (Family history) Population risk 3.2. Model selection 1. How many samples were included in the study? 3. 1 How did we address these missing SNPs? 3.1 Missing SNPs Women Navarre Figure 3. Dens	poster
U.S. Environmental Protection Agency Office of Research and Development Applying EcoToxChips to identify Potential Gene Expression Markers of Exposure to Glucocorticoid Receptor Agonists 1 ORISE Fellow, US EPA, Office of Research and Development, Great Lakes Toxicology and Ecology Division, Duluth, MN 2 US EPA, Great Lakes Toxicology and Ecology Division, Duluth, MN Introduction Principal Component Plot Conclusion Identification of Novel Transcriptomic Markers References • Among 375 genes evaluated, six genes were differentially expressed across more than one treatment and identified as biomarker candidates for GR-agonism. • The up-regulated genes were acsl5, scd, odc1, and gadd45ga. • The down-regulated genes were slc27a6 and dgat2. • These genes were all found to be sensitive at an environmentally relevant concentration of dexamethasone (40ng/L) and responded in the same direction across all treatments of dexamethasone and BDP. Furthermore, the magnitude of induction and/or down-regulation following dexamethasone was dose-dependent. • Results of this study provide additional candidate genes to consider as potential markers of in vivo exposure to GR-agonists in field studies employing caged fish. Jacob Collins1, Jenna Cavallin2, Alex Cole1, Kathleen Jensen2, Michael Kahl2, Kelvin Santana Rodriguez1, Ashley Kittelson1, Dan Villeneuve2 Glucocorticoid-mediated bioactivity has been detected in North American surface waters1. However, the bioavailability and in vivo potency of glucocorticoid receptor (GR) agonists in environmental mixtures remains undefined. • Dexamethasone (DEX) and Beclomethasone dipropionate (BDP) were used as positive controls related to glucocorticoid receptor (GR) agonism, • 40ng/L DEX was used an environmentally relevant concentration. • 18 µg/L of BDP was used as a positive control for glucocorticoid receptor agonism. • Initial selection of gene expression endpoints were based on mammalian genes known to be regulated by GR signaling: sgk1, nr3c1, nfkbiaa. Potential transcriptomic markers of GR activation were identified by the direction and magnitude of their Log2 fold change (FC). Targets that were determined to be viable were those that demonstrated a dose-dependent response. Preliminary Results 96 Hour Adult Fathead Minnow Study Test Conditions • 5-6 month old male fathead minnows (FHM) were distributed amongst 15 tanks with 3 replicate tanks per treatment. • Filtered and UV-treated Lake Superior Water (LSW) was utilized as control water. • A continuous flow through system of approximately 45mL/min was utilized. • The photoperiod was 16:8; light:dark. • Water temperature was kept at 25.3 ± 0.3°C. • FHM were fed bring shrimp twice daily. • Water conditions (temperature, pH, dissolved oxygen, conductivity, flow-rate, and survival) were monitored over the course of the test. Treatment Groups • LSW Control • Dex 40ng/L (0.1 nM) • Dex 0.40mg/L (1uM) • Dex 4.0mg/L (10uM) • BDP 17.8ug/L (34.2 nM) 1. Cavallin JE, Battaglin WA, Beihoffer J, Blackwell BR, Bradley PM, Cole AR, Ekman DR, Hofer RN, Kinsey J, Keteles K, Weissinger R, Winkelman DL, Villeneuve DL. Effects-Based Monitoring of Bioactive Chemicals Discharged to the Colorado River before and after a Municipal Wastewater Treatment Plant Replacement. Environ Sci Technol. 2021 Jan 19;55(2):974-984. doi: 10.1021/acs.est.0c05269. Epub 2020 Dec 29. PMID: 33373525; PMCID: PMC8135223. 2. Basu N, Crump D, Head J, Hickey G, Hogan N, Maguire S, Xia J, Hecker M. EcoToxChip: A next-generation toxicogenomics tool for chemical prioritization and environmental management. Environ Toxicol Chem. 2019 Feb;38(2):279-288. doi: 10.1002/etc.4309. PMID: 30693572. EcoToxChip Assay Procedure • RNA samples were converted to cDNA and combined with nuclease-free water and PCR master mix before distribution across a 96 well qPCR plate. • Samples from the 96 well plate were then transferred to a 384 well EcotoxxChip plate utilizing the Beckmen Coulter Biomek i5 • PCR analysis was perfor	poster
INTRODUCCIÓN 6 de noviembre de 2021-actualidad: La paciente mejora progresivamente, persistiendo algunos meses ciertos olvidos puntuales y conductas infantiles, hasta la práctica desaparición de sintomatología psicótica o disociativa con recuperación completa de funcionalidad personal y en sociedad. Su tratamiento de mantenimiento es: Lamotrigina 100mg. 1-0-1/2, Litio 400mg. 1/4-0-1/2, Olanzapina 2.5mg. si ansiedad o insomnio, Escitalopram 20mg. 1-0-0 A PROPÓSITO DE UN CASO INCIERTO Fombellida Velasco, C. (Licenciada Especialista en Psiquiatría); Domínguez Álvarez, E. (Licenciada Especialista en Psiquiatría); Sánchez Chillón, A. (MIR de Psiquiatría); Beltrán Mercado, C.E. (MIR de Psiquiatría) REUNIÓN 2024 EN PALENCIA DE LA 24 de mayo de 2021, Urgencias Acude por insomnio de una semana. Vacunado para SARS-COV2 recientemente. • Exp. psicop.: ansiedad ideica, discurso adecuado pero monosilábico, no clínica psicótica, insomnio. • Diagnóstico: insomnio • Plan y tratamiento: alta a domicilio con Escitalopram 10mg 1-0-0 (preeescrito por ORL privada), Trazodona 100mg. 0-0-1/2. Control por M.A.P. 11-28 de junio de 2021, Urgencias e ingreso en agudos: Dos días tras su alta, regresa a Urgencias con mutismo, ideación de culpta y ruina y tapándose la boca resistiendo la reinstauración de antipsicótico (Risperidona). • Sedimentos de orina: infección de orina Se decide ingreso: hipotimia y sensación de “ser una carga para su hijo”. Presenta picos hipertensivos alternando con hipotensión y fiebre junto a desorganización mental y conductual compatible con sdr. confusional. Buena evolución y posterior traslado a Unidad de Convalecencia. • Diagnóstico: síndrome ansioso-depresivo y disautonómico/ confusional en contexto de ITU 25 de mayo-8 de junio de 2021, ingreso en agudos: Durante su estancia en planta, la paciente está mutista y escasamente reactiva, no es posible toma de medicamento precisando adiministración i.m. mostrando mejoría significativa al día siguiente. Posteriormente gracias a tto. con Venlafaxina, Clonazepam y Risperidona mejoría gradual de sintomatología disociativa, percepciones y quejas somáticas y posibles síntomas psicóticos. Durante su estancia refirió “estar más preocupada por la pandemia, “esta no es mi voz” y “huelo mal”, “mi piel se está pudriendo” y “mi familia ha venido aquí porque estoy muerta y este es mi funeral”. • Diagnóstico: trastorno disociativo • Plan y tto.: alta con Venlafaxina 5mg. 1-0-0, Clonazepam 0.5mg. Octubre de 1987, ingreso en agudos • Ingreso breve por mutismo y obnubilación que cede con Haloperidol, Tioridazina y Flunitrazepam. • Diagnóstico: trastorno disociativo vs. psicótico (menos probable) Septiembre de 1988, ingreso en agudos: • Episodio maniaco con síntomas psicóticos y desorganización conductual severa con agitación. • Tratamiento: Haloperidol, Flunitrazepam y Valpromida, Litio • Diagnóstico: episodio maniaco con síntomas psicóticos en trastorno bipolar tipo I 25 de mayo de 2021, Urgencias Regresa acompañada de su hijo refiriendo que habla menos, casi mutismo y persiste insomnio. Sin quejas somáticas. La nota más rara desde que toma el Escitalopram por lo que lo retira. Desde hace diez días está preocupada por un posible cáncer al notar prurito laríngeo, que ha consultado con ORL privada diagnosticando reflujo gastroesofágico. • Exp. psicop.: poco colaboradora, ligera resistencia física a entrar en consulta que cede, ansiedad ideica moderada, cierta inquietud psicomotriz, mutista, insomnio. • Interconsulta a Neurología: no patología neurológica urgente • Diagnóstico: trastorno depresivo vs. disociativo a estudio • Plan: ingreso en Unidad de Hospitalización de Agudos. 28 de junio-22 de octubre de 2021, ingreso en Convalecencia Al principio miedo a comer/tragar, mostrándose insegura y no relacionándose, con clínica depresiva y episodios compatibles con cuadros disociativos que ceden con benzodiacepinas y neurolépticos sedantes. Persiste miedo a enfrentarse al exterior. Ante falta de remisión	poster
Barriers of Mental Health in Undocumented Latinos Ashley Perez, University of Illinois at Chicago Dr. Joseph Hoereth, Institute for Policy & Civic Engagement, University of Illinois at Chicago Research Objective As the rates of mental health illness continue to grow in the United States, this study aims to review what is being said when it comes to mental illness and undocumented Latino immigrants. Taking the opportunity to peer into what is being said in the subpopulations within the undocumented Latino immigrants: women, men, and youth. The question that is being explored is: What are the barriers to accessing mental health services for undocumented Latino immigrants in the United States? The purpose of this study is to encourage researchers to ensure they are acutely aware of the subpopulations of undocumented Latinos that need to be included in studies that focus on mental health and to encourage policymakers to include undocumented Latino immigrants in public policy to increase access to mental health services. Methodology (Literature review: 1985 to 2022) Journals: J. of Consulting & Clinical Psychology, Hispanic Health Care Intern., Intern. J. Of Geriatric Psychiatry, American Psychiatric Association, American Psychiatric Nurses Association, Advances In Nursing Science, Medical Care, Psychiatric Services, Social Science & Medicine, Hein Law J., American Association of Nurse Practitioners, Social Science & Medicine, Health Politics Policy Law, J Immigrant Minority Health. Latinos in General Undocumented Latinos in General Undocumented Latina Women & Depression Undocumented Latino Men & Emotionality • Depression in Latina women is more prevalent with only 13.8% of Latinas receiving any type of mental health support in 2008 (Shatell, 2008). • In 2016, 10% of undocumented Latina immi- grants received mental health care when 45% met the criteria for depression (Derr, 2016). • Latina women are more likely to have higher rates of post-partum depression with 60% of undocumented Latina immigrants showing sig- nificant PPD that could lead to suicidal think- ing, according to a study conducted in 2013 (Shellman, 2013). • Latino men have higher rates of successful suicide than Latina women, four times the rate in 2018 (CDC, 2021). • Undocumented Latino men are more likely to experience restrictive emotionality and depression due to the cultural values of being the breadwinners of their families. • The stress to support their families in addition to other stressors such as experiencing racism, expectations based on their gender, physical strains due to work could ultimately lead to men feeling overwhelmed, burnout, and experiencing symptoms of depression. Undocumented Latino Youth & Immigration Trauma Policy Recommendations Findings • Undocumented Latino youth who experiences traumatic events in their home countries had higher levels of depression, anxiety, post-traumatic stress disorder due to the journey of immigration and acculturation. • Where two-third of youth out of a 104-youth study (69.3%) that was surveyed had experienced at least one traumatic event that deeply influenced the mental health of the youth (Cleary, 2018). • As of 2022, there are no healthcare policies within federal or state levels that include undocumented immigrants within their framework. • “Undocumented immigrants are explicitly excluded from the Patient Protection and Affordable Care Act’s (ACA) health insurance exchanges, cost-sharing reductions, health insurance mandate, tax credits, and the expansion of Medicaid’s traditional provisions.” (Ortega, 2018). • Undocumented Youth who are DACA (Deferred Action for Childhood Arrivals ) recipients reported “Majority reported not being offered coverage. As they are disqualified for coverage through the Affordable Care Act (ACA)” (Siemons, 2017). • Improvements and revisions to the policies around government healthcare programs such as Medicaid, Medicare & Affordable Care Act to be inclusive of the entire popul	poster
SFB 1391 Andere Ästhetik Gastvortrag Dr. Grace Stafford (Universität Wien) Women’s Patronage and Visual Culture in Late Antiquity: From Honorific Statuary to Donor Portraits Mittwoch, 29. Mai 2024, 18 Uhr c.t. Ernst von Sieglin Hörsaal (Raum 165), Schloss Hohentübingen, Burgsteige 11, 72070 Tübingen Alle Interessierten sind herzlich willkommen! Der Vortrag findet statt im Rahmen des Teilprojekts A1: Ästhetik der Ämter: Repräsentation spätrömischer Reichsbeamter (4.–6. Jh.) Prof. Dr. Cristina Murer, Prof. Dr. Sebastian Schmidt-Hofner, PD Dr. Martin Kovacs	poster
Material Normalised RMS (mV/g-1s) Lactose 200M 121 ± 15% Avicel PH102 30 ± 3% Avicel PH101 23 ± 8% Maize Starch 12 ± 7% Lactose #316 Fast Flo 4 ± 7% Feasibility study on the in-line measurement of pharmaceutical powder mass flow rate and charging characteristics using an electrostatic powder flow sensor (EPFS). Hill-Izani, N.Y., Smith, G., Armitage. D.A., Polygalov, E. Pharmaceutical Technologies, School of Pharmacy, De Montfort University, Leicester LE1 9BH Results 16.548 33 21.998 62 26.308 28 30.601 90 R² = 0.88 0 5 10 15 20 25 30 35 40 0 1 2 3 4 5 6 7 8 9 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 160 rpm 140 rpm 380.82 116 521.37 139 572.27024 673.21 304 R² = 0.96 0 200 400 600 800 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 38.974 25 51.094 51 60.149 30 65.85456 R² = 0.92 0 20 40 60 80 100 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 60.377 08 55.837 13 60.326 07 63.922 40 R² = -7.16 0 20 40 60 80 100 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 74.520 38 81.850 41 75.881 74 76.844 03 R² = -15.13 0 50 100 150 200 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm Lactose #316 Fast Flo Lactose 200M Maize starch Avicel PH101 Avicel PH102 Powder mass flow rate vs RMS signal Fig. 5. Mean powder mass flow rate and mean RMS signal correlation, recorded for five pharmaceutical powders conveyed using the twin screw feeder across a range of screw speeds. Powder mass flow rate vs powder velocity Conclusions Table 3. Ranking in the normalised charges recorded for five pharmaceutical powders conveyed at 100rpm. Introduction Materials & Methods Fig. 2. EPFS and measurement electronics principle of operation. References DAQ PC Balance - + - e- + + Charge output Inverting input of Op. Amp. Flow of current Summing point (virtual ground) EPFS Charged particle Flow direction Induced charge • Electrostatic induction sensors are widely used to measure in-line particle flow parameters in pneumatic conveying processes [1], but are rarely utilised in pharmaceutical flow regimes. • Triboelectrification may result in powder adhesion to processing equipment [2]. Material charging differences are typically measured using tribo-series and Faraday Cup [3]. However, tribo-series only qualitatively ranks charging behaviour specific to the conditions at which the measurements were performed, whereas the Faraday Cup cannot be integrated into processes. • In this study, an electrostatic powder flow sensor (EPFS) was developed to directly measure in-line flow parameters and charging behaviour of powders conveyed in a pharmaceutical process. EPFS Volumetric twin screw feeder (T20, K-Tron) Solid-state balance Fig. 3. Lean phase conveying system, (measurement electronics not shown). • Electrostatic and gravimetric measurements were recorded for five “as received” powders and one oven-dried powder, which were conveyed using a twin screw feeder. • Particle velocity was obtained via cross-correlation algorithm (1), using the upstream and downstream electrostatic signals. • RMS signal was calculated by averaging values across consecutive 0.05s (20Hz) intervals over the entire electrostatic dataset. • Charging behaviour was analysed by normalising the RMS of the electrostatic signal against the mass flow rate. Fig. 4. Powder deposition behaviour for a) Avicel PH102; b) Lactose #316 Fast Flo; c) Avicel PH101; d) Lactose 200M and e) maize starch. • Particle velocity was independent of the screw speed (Table 1). • Differences in the particle velocities were thought to be influenced by powder deposition sizes (Fig. 4), which resulted from differences in the cohesivity of the entrained powder. • Similar rankings were shown between particle velocity and the cohesivity dependant FT4 parameters (Table 2). • Reasonable correlation was shown (R2 > 0.88) between the mass flow rate and RMS obtained	poster
No-code machine learning workflows and data exploration: nanoHUB’s efforts on FAIR data Juan C. Verduzco School of Materials Engineering Purdue University West Lafayette, IN, USA jverduzc@purdue.edu Daniel Mejia Network for Computational Nanotechnology Purdue University West Lafayette, IN, USA denphi@denphi.com Steven Clark San Diego Supercomputer Center University of California San Diego San Diego, CA, USA smclark@sdsc.edu Alejandro Strachan School of Materials Engineering Purdue University West Lafayette, IN, USA strachan@purdue.edu Abstract— Predictive models based on machine learning algorithms have been widely adopted across the quantitative sciences. Access barriers to advanced simulation and data tools and specialized hardware hinder progress in most scientific and engineering disciplines. While there have been advances in making research data findable, accessible, interoperable, and reusable (FAIR), scientific workflows (for machine learning, simulations, and experimental analysis) remain poorly documented and are often not accessible. Together with the need for advanced scientific computing tools and appropriate educational materials to train the next generation workforce, application of the FAIR principles on such workflows are crucial for the community’s efforts to ensure scientific reproducibility of results. nanoHUB’s mission to make scientific software useful to the research community has been evidenced in many of the platform’s efforts to remove such barriers. For example, the introduction of Sim2Ls, a novel library that allows researchers to develop and disseminate end-to-end workflows with verified and documented inputs and outputs. Making use of nanoHUB’s Sim2Ls, tool developers can document their scientific workflows, and make them available for online simulations by publishing in nanoHUB. Many journals incentivize researchers to share scripts necessary for their analysis through repositories. Using nanoHUB’s tools, developers can not only achieve that, but also create containerized versions of their environments so potential reviewers and future researchers have access to a functional ready-to-run version of their work. The contribution discussed in this presentation describes ongoing efforts in nanoHUB.org towards making scientific workflows and the data generate FAIR, as well as making data science tools available to non-experts. No-code machine learning (no-code ML) allows non-experts to model data and make predictions using advanced ML tools and algorithms though an intuitive graphical user interface available through a web-browser. Thus, users with little to no experience in code development can access predictive algorithms from their preprocessed data. Using a no-code ML approach both ensures that the ML pipeline contains all necessary steps for adequate testing and that it avoids many methodological pitfalls that can compromise reproducibility. Additionally, the use of nanoHUB’s Sim2Ls also makes the workflow and the data generated more accessible as all inputs, outputs, and results are automatically indexed and cached in nanoHUB’s ResultsDB. The ResultsDB allow for efficient caching, storage, exploration, and visualization of simulation results. Scientific workflows stored in the ResultsDB may also include metadata and details about code execution. Importantly, all data generated can be queried using simple python commands to make data accessible to the community and, at the same time, allow for further investigation in different areas of interest. Keywords—machine learning, cyberinfrastructure, scientific workflows "Presented at Gateways 2022, San Diego, USA, October 18--20, 2022. https://zenodo.org/communities/gateways2022"	poster
The authors gratefully acknowledge the EPSRC (Engineering and Physical Sciences Research Council, UK) and Westinghouse Electric Company for their financial support. - <a> loops were present from 0.1 dpa but were not aligned along the basal planes. - Sn is known to repel <a> loops. With low Sn alloying additions in w13, Sn bands were low in concentration. Perhaps this allowed <a> loops to diffuse throughout the microstructure. - In alloys with higher Sn content such as Low Tin ZIRLO and Zircaloy-2, loop alignment becomes progressively stronger. - Discrepancies between XRD- LPA and TEM densities may be due to small <a> loops forming that were not resolvable in TEM. With increasing dose these loops grew to resolvable sizes, decreasing XRD-LPA density with no effect on TEM. - <c> loops were first observed at 12.1 dpa. They increased in density to 33.5 dpa alongside breakaway IIG. - It is proposed that <c> loops form from the transformation of larger vacancy-type <a> loops. - Cu segregated to <c> loops. Cu may diffuse to vacancies, creating Cu-vacancy pairs which later exchange with SIAs. This may help to reduce loop growth rates, delaying breakaway IIG. The effect of Cu on irradiation-induced growth mechanisms in Zr alloys following neutron irradiation C. Andrew (1), W. Zhang (2), A. Carruthers (1), R. Thomas (1), X. Liang (1), Ö. Koç (1), J. Partezana (3), M. Limbäck (3), Z. Shah (3), M. Maric (1), R. W. Harrison (1), P. Frankel (1). (1) - University of Manchester (2) - University of Oxford (3) – Westinghouse Electric Company W13 alloy composition Element Atomic Percent (at.%) Zr 98.49 Nb 0.97 Sn 0.23 Cu 0.23 Fe 0.08 Figure 1: IIG profile of neutron irradiated Zircaloy-2, Low Tin ZIRLO™ and W13 alloys SPP formation in W13 SPP type Mean Diameter (nm) Area fraction (%) Zr2Cu 277 (± 119) 0.55 β-Nb 51 (± 36) 3.40 Zr(Nb, Fe)2 117 (± 71) 1.11 2. Baseline Microstructure Characterisation 3. Irradiated Microstructure Characterisation 4. Dislocation Loop Evolution - The matrix was depleted in Cu, Nb and Fe, and enriched with Sn. - Zr2Cu, β-Nb and Zr(Nb, Fe)2 Laves phase SPPs formed in 1 µm thick bands. Zr2Cu SPPs were coarse but sparsely distributed within the bands. This SPP distribution may have affected the IIG rate of W13. Figure 3: STEM-EDS map of SPP dispersion in the W13 alloy - Zr2Cu SPPs depleted in Cu content, forming a shell from the core to the interface. - Full dissolution of Zr2Cu SPPs was observed at 33.5 dpa. - Cu formed bands along the basal planes of grains, alongside Fe and Sn. Irradiation-induced Nb SPPs formed along the basal planes as well. - Cu likely diffused along the c-axis of grains to sinks on the basal planes to create this banding structure. - Cu banding was strongest near Zr2Cu SPPs. Cu was co-segregated with Fe and anti-segregated with Sn, forming an alternating banding structure. - Segregation between Sn and Cu/Fe bands was not as strong in the matrix. This may be because of the low alloying concentrations of Sn and Fe in the W13 alloy. Additionally, as a β- stabilizer, Cu was confined to the vicinity of SPPs and was not dispersed throughout the matrix. Figure 5: STEM-EDS map of a dissolved Zr2Cu SPP at 33.5 dpa, highlighted by a blue circle Figure 10: Cu segregation to <c> loops (dotted line) at 33.5 dpa Figure 8: <c> loop evolution in the W13 alloy observed through TEM Figure 7: <a> loop evolution in the W13 alloy observed through TEM Acronyms APT – Atom probe tomography DPA – Displacements per atom SIA – Self-interstitial atom SPP – Second phase particle References (1) – R. Konings, R.E. Stoller, Comprehensive Nuclear Materials, Elsevier, 2020. (2) – P.M. Kelly, R.G. Blake, The Characterization of Dislocation Loops in Neutron l Irradiated Zirconium, Philos. Mag. 28 (1973) 415–426. (3) – G. Pan, et al. Advantages gained by Optimized ZIRLO and AXIOM PWR cladding l l materials. ANS, 2016 Figure 2: The texture of the W13 alloy via electron backscatter diffraction analysis Irradiation information Irradiation	poster
How to represent materials knowledge? Ontology CSSI Element: Nanocomposites to Metamaterials: A Knowledge Graph Framework PI: L. C. Brinson,1 Co-PIs: C. Rudin,1 W. Chen,2 D. McGuinness,3 C. Daraio,4 L. Schadler5 Institutions: 1Duke University, 2Northwestern, 3Rensselaer Polytech. Inst., 4Caltech, 5Univ. Vermont Award #: OAC-1835677 NSF CSSI PI Meeting, Alexandria, VA, July 25-26, 2022 MaterialsMine enables materials discovery and design via an extensible digital toolkit for sharing and visualizing materials research data. Take a picture to download the full poster Nanocomposites to Metamaterials: A Knowledge Graph Framework ● Capture data “from the wild” and apply metadata that make datasets searchable and interoperable ● As of July 13th, 244 papers from the literature and 2568 total experimental samples ● MS Excel-based template contains all parameters within XML schema ● Custom-configured Excel templates facilitate entry of many samples ● Conversion tool maps data from Excel templates into corresponding fields in XML database ● Excel template and data uploader are extensible and have been shared with NIST for use in other data resources How to ingest data? Data Curation Nanomine Data Demonstrated the interpretation of the model by modifying the inputs and correlated the learning with physical understanding What can be learned from the data? NanoMine Data Case Study New insights about the interplay of interphase, volume fraction and dispersion, explaining tan d trend in experimental data within NanoMine Microstructure Characterization & Reconstruction (MCR) This work aims to produce an organized, searchable, extensible repository of data on polymer nanocomposites and structural meta- materials complete with a suite of analytical and predictive tools to help spur the discovery of new materials. Metadata include materials information, composition, processing, measured properties, microstructure, and data provenance. Data generation over a wide range of shapes & properties Data-driven metamaterials design MetaMine Data Case Study Machine learning structure-property models 88,000 2D unit cells 8,000 3D unit cells Deep learning latent shape space Intelligent Characterization Statistical Reconstruction Help users select the appropriate MCR technique and achieve microstructure information following the NanoMine schema NanoMine For Polymer Nanocomposites MetaMine For Metamaterials NLP-driven Data Curation Future work Improve the Ease of Use By the Community! Future work We are building a Natural Language Processing (NLP) pipeline with two tasks to achieve (semi-)automated curation of archival polymer nanocomposites data in journal papers. ● Preliminary work achieves a micro-averaged F1 score of 0.87 on Named Entity Recognition (NER) task. ● Collected a polymer composite corpus of 23k+ papers. ● Annotated 1896 figure captions for NER and Relation Extraction (RE) task. NLP-Driven Data Curation ● To identify samples and properties being measured to populate the structure of a Schema ● Automatic population of the schema with user verification Modification of the ontology / Knowledge Graph from a user friendly interface Materials-Information Twin Tetrahedra (MITT) The paradigm shift toward data-intensive scientific research relies on collaboration between numerous disciplines and stakeholders. ● MITT is the nexus joining materials and information science, adapted from the concept of a “digital twin” ● Provides stakeholders with a platform to contextualize, translate, and direct efforts for next generation materials science advances QR Code Here Glass transition temperature (Tg) is tunable by changing the chemistry of the interface between the nanoparticles and polymer matrix. A case study using NanoMine and the Polymerizer web tool to investigate the relationship of the shift in Tg and parameters such as nanoparticle volume fraction and surface energies showed: ● Machine Learning could be used to show a quantitative relationship between s	poster
Seasonal prediction in northern Atlantic Ocean and Norwegian Seas Noel Keenlyside1,2,3, Sunil Pariyar1,3, Ingo Bethke1,3, Yiguo Wang2,3, and Francois Counillon2,3 1University of Bergen, Geophysical Institute, Bergen, Norway, 2Nansen Environmental and Remote Sensing Center, Bergen, Norway, 3Bjerknes Centre for Climate Research, Bergen, Norway 1. Main research question: What are the sources of seasonal SST prediction skill of NorCPM over the North Atlantic? 2. Model and data Norwegian Climate Prediction Model version 1 with Ensemble Kalman Filter data assimilation method  Historical simulation: 30 ensemble members  Hindcasts: decadal hindcast starting in 15 October (10 ensemble members)  NOAA OI-SST (1982-2018) 3. SST prediction skill 4. Contribution from low (>5-years) frequency variability 4. Contribution from external forcing and internal variability 5. Role of Ocean (Annual ocean heat budget) Fig. 1. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018 Fig. 2. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018 based on 5 years lowpass filtered data Fig. 4. Annual SST tendency variance explained (%) by column integrated heat divergence and net surface heat flux Fig. 3. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018. The total skill is separated into internal variability (top panel) and external forcing (bottom panel).	poster
Analysis of Herbal Dietary Supplements Gwyndolyn Jones, Katie Wiley, Morgan Shirley, Reed Eisenhart, Tom Linz, Robert Dunn Department of Chemistry, The University of Kansas The use of herbal supplements is a growing trend in the United States. Americans spent over 22 billion dollars on herbal supplements alone in 2006. Under the 1994 Dietary Health Act, only prescription and over-the-counter drugs are regulated and require FDA approval, so there are no mandatory requirements for safety or quality testing of herbal supplements. Some manufacturers adulterate their products with pharmaceuticals or other synthetic compounds to enhance their effects without any clear remark on the ingredient table. This research speciﬁcally investigated male sexual enhancement drugs, and weight loss pills claiming to contain “Hoodia”, a cactus extract thought to suppress appetite. For the male sexual enhancement drugs, our concern was whether the manufacturers illegally adulterated their products with prescription drugs, such as sildenaﬁl [Viagra®], tadalaﬁl [Cialis®], and vardenaﬁl [Levitra®]. Using HPLC-MS and UV-Vis, we have identiﬁed and quantiﬁed the presence of those compounds in the pills. For the weight loss products claiming to contain “Hoodia,” our concern was whether manufacturers adulterated their products with synthetic compounds known to increase metabolism and suppress appetite, such as caffeine and chromium. We have identiﬁed and quantiﬁed the presence of caffeine, chromium, and the active ingredient in Hoodia, steroidal glycoside P57, using HPLC-MS and graphite-furnace AAS. ! Abstract Background: Herbal Supplement Study 1: Male Enhancement Pills Acknowledgement Robert Dunn Tom Linz • Under the 1994 Dietary Health Act, only prescription and over-the-counter drugs are regulated and require FDA approval • Over $40 billion is spent each year on herbal supplements in U.S. • FDA is responsible for taking action against any unsafe dietary supplement product, however they can only investigate products after they reach the market • Last year, FDA investigated 80 dietary supplement marketers recalling illegal products resulting from mislabeling Problems with Herbal Supplement • Prescription pharmaceuticals have been found in herbal supplements, creating problems for the consumer • interactions with medication • allergic reactions • side effects • If Viagra is taken with certain other drugs, the effects of either could be altered • Erythromycin (E-Mycin, Ery-Tab, PCE) • Itraconazole (Sporanox) • Nitrates such as Isordil, Nitro-Bid, and Nitro-Dur Rifampin (Rifadin, Rimactane) • Overdose of chromium can cause several effects stomach, liver, kidney, and lung damage • irregular, fasten heart rhythm • inhibits insulin Objectives • Male enhancement supplements: This group will focus on the contamination of herbal supplements with pharmaceuticals, speciﬁcally male performance supplements that have been adulterated with sildenaﬁl citrate (Viagra®), vardenaﬁl (Levitra®) and tadalaﬁl (Cialis®) • Weight loss supplements: This group will focus on the use of Hoodia in weight loss pills to determine if the active ingredient P57 is in the actual pill and if the pill has been contaminated with other known appetite suppressants Study 2: Weight Loss Pills Male Enhancement Pills 100% Natural and Herbal Extract Pills that we tested Research of Interests Research of Interests Sildernafil Quantification Tadalnafil and Vardenafil Conclusion Chromium Quantification Caffeine Quantification Conclusion P57 Identification Sildenaﬁl Viagra® Vardenaﬁl Levitra® Tadalaﬁl Cialis® • Synthetic molecules not found in nature • Prescription medicine • Warning is required if you are taking nitrates that might lower blood pressure leading to a heart attack. More reports are linking Tadalaﬁl to stokes. • Pills were dissolved in methanol • Calibration curve was ﬁrst constructed • HPLC-UV/MS, UV-Vis were used • LOQ and LOD were determined as 15 ng and 3 ng for MS selected ions • Minim	poster
Compact, Quality-Preserving Energy Booster for Intense Laser-Plasma Ion Sources M. Garten, S.S. Bulanov, S. Hakimi, L. Obst-Huebl, C.E. Mitchell, C. B. Schroeder, E. Esarey, C.G.R. Geddes, J.L. Vay and A. Huebl Lawrence Berkeley National Laboratory, Berkeley, CA, USA This material is based upon work supported by the Defense Advanced Research Projects Agency via Northrop Grumman Corporation. Partly supported by the U.S. DOE FES Postdoctoral Research Program, administered by ORISE under contract DE-SC0014664, the U.S. DOE Office of Science Offices of ASCR, HEP and FES (incl. LaserNetUS) under Contract No. DE-AC02-05CH11231, the Scientific Discovery through Advanced Computing (SciDAC) program, and the Exascale Computing Project (17-SC-20-SC). This research used resources of the Oak Ridge Leadership Computing Facility at the ORNL (DE-AC05-00OR22725, ALCC program) and the National Energy Research Scientific Computing Center (DE-AC02-05CH11231, FES-ERCAP0024250). We thank R.T. Sandberg, D. Terzani, R. Lehe and J. Qiang for helpful discussions. Simulations used the open source particle-in-cell code WarpX in version 23.01. We acknowledge all WarpX contributors. DOI:10.5281/zenodo.11217273 Laser-Plasma Ion Sources unique, pulsed, ultra-intense TE Cowan et al., PRL 92 (2004) F Wagner et al., PRL 116 (2016) A Higginson et al., Nat. Comm. 9 (2018) M Rehwald et al., Nat. Comm. 14 (2023) T Ziegler et al., Nat. Phys. (2024) First Quality-Preserving Plasma Staging Concept for Ultra-Intense Ion Bunches M Garten et al., "Laser-Plasma Ion Beam Booster Based on Hollow-Channel Magnetic Vortex Acceleration", under review, arXiv:2308.04745 (2024) ✓open-source development ✓scalable multi/manycore CPUs/GPUs from laptop to ExaFlop/s supercomputer ✓multi-platform Linux, macOS, Windows ✓multi-disciplinary ✓extensive documentation ✓large & active community Full 3D Simulations show robustness & capture efficiency WarpX is part of the Beam, Plasma & Accelerator Simulation Toolkit Electromagnetic particle-in-cell modeling of laser-plasma physics includes all relevant relativistic and kinetic effects from first principles. WarpX is developed by leveraging expertise in physics, applied math & HPC in collaboration with US and international collaborators. We organize in Open Governance and join the: Created in laser-plasma interaction, driven by laser intensities ≈1023 W/cm2 ●ultra-low emittance (≪ 20 nm) ●very high charge (≫ 100 pC) ●large current (> kA) ●ultra-short (10s of fs) ●TV/m fields for compact acceleration length (≈ few μm). With current short-pulse Petawatt laser facilities, laser-ion acceleration remains an indirect process due to the high mass of ions compared to plasma electrons. Experiments demonstrated 150 MeV / u. Maximum proton energy for selected laser-ion acceleration mechanisms. Ref.: S Hakimi et al., PoP 29 (2022) Temporal & Spatial Tolerance energy boost and capture efficiency are within experimentally achievable tolerances & source parameters Magnetic-Vortex-Acceleration combines strong ●accelerating and ●focusing fields with 10s of MV/μm. At BELLA iP2, first experimental campaigns that explore MVA as a source are underway. Now, a plasma ion accelerator will need booster elements, too! We propose a new concept & self-consistent numerical proof: plasma staging of sub- to fully relativistic ion beams. Modified MVA stage with a pre-formed hole supresses low-energy ion injection – instead boosts a well-timed, external ion beam. Self-consistent 3D modeling, boosting a space-charge dominated 200 pC proton beam (35 kA, dƐ=5%). Quality-preserving: ✓charge (perfect) ✓emittance (+3.5nm) ✓energy spread (+2%) Outlook pivotal applications, realization in current or near-term laser facilities, interstage transport L Obst-Huebl et al., SPIE (2023) AD Piazza et al., MP3 workshop report (2022) S Busold et al., TUME030, IPAC14 and NiMA 740 (2014) and Sci. Rep. 5 (2015) Could boost laser-ion beams relevant to fundamental research & applications, e.g., futu	poster
Data-Depositing in der Task Area Collections Ein zentraler Baustein des NFDI-Konsortiums Text+ ist die Entwicklung einer Infrastruktur für die langfristige Bereitstellung und Archivierung von nachnutzbaren text- und sprachbasierten Forschungsdaten. An der verteilten Infrastruktur von Text+ beteiligen sich verschiedene Daten- und Kompetenzzentren mit ihrer je eigenen Expertise zu bestimmten Datentypen. Die elf Zentren der Task Area Collections gliedern sich in drei Cluster: gegenwartssprachliche Daten, historische Texte und unstrukturierte Texte. Zur Datenhaltung nutzen sie zertifizierte Repositorien. Durch die Aufnahme von Daten in eine der an Text+ beteiligten Einrichtungen wird eine nachhaltige Datenhaltung (gemäß FAIR/CARE) sichergestellt und die Nachnutzbarkeit (z.B. über LRS, Geo-Browser) sowie die Auffindbarkeit über zentrale Nachweissysteme erhöht. Wohin damit? Wir geben Ihren Daten ein Zuhause Collections Lexical Resources Editions Infrastructure/ Operations The NFDI consortium Text+ is funded by Deutsche Forschungsgemeinschaft (DFG), project number 460033370. Text+ is part of https://www.text-plus.org Beteiligte Daten-/Kompetenzzentren Christoph Draxler (LMU München), Philippe Genêt (Deutsche Nationalbibliothek), Marius Hug (Berlin-Brandenburgische Akademie der Wissenschaften), Timm Lehmberg (Akademie der Wissenschaften in Hamburg), Thorsten Trippel (IDS Mannheim, Universität Tübingen) Datenzentrum Spezialisierung Berlin-Brandenburgische Akademie der Wissenschaften (BBAW): Deutsches Textarchiv ●deutschsprachige Texte (ca. 1600–1920) ●hochwertige Transkriptionen/Metadaten ●strukturiertes Textformat und offene Lizenz Deutsche Nationalbibliothek (DNB) ●in Deutschland erschienene Publikationen und Tonträger ●Werke, die in deutscher Sprache erstellt wurden oder einen Bezug zu Deutschland haben Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen (GWDG): Text+ Langzeitarchiv ●alle Daten mit geisteswissenschaftlichem Bezug Leibniz-Institut für Deutsche Sprache (IDS) ●geschriebene und gesprochene neuhochdeutsche Sprache ●linguistisch annotierte Korpora ●Deutsch in nicht-primär deutschsprachigen Ländern Ludwig-Maximilians-Universität München: Bayerisches Archiv für Sprachsignale Repository (BAS) ●gesprochene Sprache mit zeitalignierter Annotation ●Repository und sprachtechnologische Webdienste für Grundlagenforschung und Technologieentwicklung Niedersächsische Staats- und Universitätsbibliothek Göttingen (SUB): DARIAH-DE Repository; TextGrid Repository ●geistes- und kulturwissenschaftliche Forschungsdaten aller Typen ●Fokus auf XML TEI-kodierte Texte und Bilder Universität des Saarlandes (SLUni): Repositorium für Sprachressourcen ●annotierte Korpora geschriebener Sprache ●fremdsprachliche und multilinguale Sprachkorpora (parallele und vergleichbare Korpora) ●registerspezifische Korpora Universität Duisburg-Essen (UniDUE): Kompetenzzentrum für parlamentarische Sprachdaten ●Aufbereitung, Bereitstellung und Analyse von parlamentarischen Sprachdaten ●Verknüpfung (Data Linkage) Universität Hamburg (UniHH): Hamburger Zentrum für Sprachkorpora (HZSK), Akademie der Wissenschaften in Hamburg ●Interdisziplinarität und linguistische Diversität ●Korpora gesprochener Sprache Universität Tübingen (UniTÜ): Tübingen Archive of Language Resources (TALAR) ●Baumbanken/Treebanks ●Wortnetze ●Word-Embeddings Universität zu Köln (UniK): Data Center for the Humanities Köln ●Audiovisuelle Sprachkorpora, Oral Literature Sammlungen ●Datenarchivierung (Dark & Cold Archiving) ●Automatisierte Datenpublikation via Zenodo Gegenwartssprachliche Daten ●soziolinguistische Interviewdaten ●Dokumentation des Sprachwandels ●Anwendungsorientierte Sprachdaten ●... Historische Texte ●Novellen aus dem 19. Jahrhundert ●Briefkorpus (1745–1872) ●Pesttraktate (1473–1700) ●... Unstrukturierte Texte ●Online-Hochschulschriften ●E-Journals ●E-Books ●... Daten mit geisteswissenschaftlichem Bezug ●Projektergebnisse (PDF, TEI, METS, IIIF etc.) und sonstige Projektda	poster
Secure sharing of molecules and bioactivity data using mobile apps. The technologies already exist that enable the scientist to securely share molecule structures or structure-activity relationship (SAR) tables for multiple molecules with one or more other scientists (perhaps even a group). This can be done for a very small investment. We now describe how just 2 commercial cheminformatics apps can enable such sharing at very reasonable cost ($25). SAR Table: A specialized editor for building tables containing an homologous series of scaffolds and substituents, creating composite structures, and providing activity data. Can be used to prepare figures for manuscripts, or to recreate data from the literature. MolSync: A chemistry-aware client for remotely stored files hosted by Dropbox. Provides viewing and editing capabilities, as well as serving as an intermediary for sharing content with other apps. It can also be used to explicitly synchronize data with other apps. Molecules can be sketched in SAR Table and then shared via MolSync. MolSync enables files to be readily deposited in DropBox folders. This cloud-based storage facility provides a free capability to share (securely) limited amounts of data with selected individuals. This approach represents a very cost effective way to enable secure chemistry and bioactivity data sharing. When data is ready to be shared openly a third mobile app can be used. The Open Drug Discovery Teams (ODDT) project uses a free mobile app as the user entry point http://tinyurl.com/6l9qy4f. The app has a magazine-like interface, and server-side infrastructure for hosting chemistry-related data as well as value added services. The project is open to participation from anyone and provides the ability for users to make annotations and assertions, thereby contributing to the collective value of the data to the engaged community. The infrastructure for the app is currently based upon the Twitter API and uses Google Alerts RSS feeds as a useful proof of concept for a real time source of publicly generated content. Using Twitter, users can easily push data from SAR Table or MolSync into ODDT. Secure Sharing with Mobile Cheminformatics Apps Followed by Open Publication When Ready Sean Ekins1 and Alex M. Clark2 1 Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay Varina, NC 27526, U.S.A., 2 Molecular Materials Informatics, Montreal, Quebec, Canada H3J 2S1. B http://collabchem.com User tweets with #leishmaniasis The App Content from web Links to papers, blogs, websites Get ODDT here for free When ready for public sharing push to ODDT Showing molecule and bioactivity data export to Molsync Showing data in Dropbox and how its limited access Showing how when ready, a subset or all data can be tweeted to ODDT	poster
1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic; 2 Department of Statistical Modelling, The Czech Academy of Science, Czech Republic; 3 Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Czech Republic Correspondence: jovanabrkic37@gmail.com; gajdosp1@faf.cuni.cz; veronika.kubikova11@gmail.com; jreissigova@seznam.cz; fialovad@faf.cuni.cz Jovana Brkić1, Petra Gajdošová1, Veronika Kubíková1 , Jindra Reissigová2 , Daniela Fialová1,3 Introduction Potentially inappropriate prescribing, including prescribing potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), is highly prevalent in older adults.1-7 The aim of our study was to determine the prevalence of cardiovascular (CV) PIM use in older patients admitted to acute care in the Czech Republic. This poster presents preliminary results of in-progress research within Horizon 2020 EuroAgeism project (10 countries, 4500 patients) and relates also to the scientific work of the European INOMED project. Analyses of potentially inappropriate cardiovascular medication use in acutely hospitalized older patients in the Czech Republic Methods The data for this preliminary analysis were collected at two acute care geriatric departments in two bigger cities in the Czech Republic (Brno and Hradec Kralové) from August 2018 to January 2019. Patients admitted to geriatric wards were assessed, excluding subjects severely cognitively impaired (Mini-Mental State Examination, MMSE <10), terminally ill or admitted to the intensive care unit. Data were collected from medical records and interviews with healthcare professionals and patients using a comprehensive instrument. Several scales of interRAI Organization were used for assessment of functional status, namely Depression Rating Scale (DRS), Cognitive Performance Scale (CPS) and ADL and IADL hierarchy scales. Also, other information related to diseases, symptoms, medication use, utilization of healthcare services, and satisfaction with care provision were collected. CV PIM use was assessed by trained researchers using several consensus‐based explicit criteria, namely Screening Tool of Older Person’s Prescriptions (STOPP)3, Screening Tool to Alert doctors to the Right Treatment (START)3, EU(7)-PIM list4 and Beers criteria 20195. In total, 99 individual criteria were applied. The study was approved by the Ethical Committee of the Charles University, Faculty of Pharmacy and by Ethical Committees of participating acute care hospitals. Results Of the 288 patients assessed, 57 % (164) were women. The patient age distribution was as follows: 35.8 % were 65-74 years, 35.4 % were 75-84 years, 27.1 % were 85-94 years and 1.7 % were 95 years and older. Overall, 77.6 % of patients were exposed to CV PIMs. The highest prevalence of CV PIMs was identified by START criteria (63.2 % of older patients), followed by EU(7)-PIM list (31 %). The lowest prevalence was documented using Beers criteria 2019 (16.1 %). (see Tables 1,2,3) Conclusion The use of CVS PIMs is highly prevalent in older hospitalized patients in the Czech Republic. The results varied according to different criteria and the highest prevalence was identified by START criteria. We intend to conduct further analyses using data of the whole Horizon EuroAgeism H2020 project when data collection is finalized in December 2020. For more information on Horizon 2020 EuroAgeism and INOMED projects visit websites:https://portal.faf.cuni.cz/Projects/Euroageism-Project/; https://portal.faf.cuni.cz/Careers/InoMed- Researcher-201910/ Tables 1) Prevalence of patients with 1+ CV PIM 2) Prevalence of patients using 0,1,2,3,3+ CV PIMs 3)Top 3 most often used CV PIMs Literature cited 1.O’Connor et al. Drugs Aging. 2012. 2. Fialová et al. Eur J Clin Pharmacol. 2019. 3. Fialová et al. J Am Med Assoc. 2005. 4. Gallagher et al. Eur J Clin Pharmacol. 2011. 5. Morin et al. J Am Med Dir Ass	poster
Design of the TUMBLE chamber’s turbulence generator • The chamber TUMBLE studied by Le Dortz [2] was modified in order to be able to control the turbulence intensities and the turbulent length scales. • Based on literature review [3], a set of 3 perforated plates were chosen. Introduction IWPD and ICVDCW 2022 August 15-19, 2022 Berlin, Germany Experimental characterization of ignition events in CVC like conditions M. C. de Jesus Vieira, J. Sotton, M. Bellenoue, C. Strozzi maria-clara.de-jesus-vieira@ensma.fr Institut Pprime, CNRS, Université de Poitiers, ISAE-ENSMA, F-86962 Futuroscope Chasseneuil, France Concepts and project overview Concepts and project overview Conclusion and perspectives • Since early development, the thermodynamic cycle used in gas turbines has undergone little change. Over the last decades, an effort has been put into increasing efficiency by reducing losses and raising the overall pressure ratio and peak temperature. One of the most promising new types of cycles is the case where a pressure rise across the combustion process is allowed (CVC). In this case, an ignition in each cycle will be considered and also diluted mixtures with high mean velocities and turbulent flows. The main objective of this work is to experimentally investigate the different phenomena involved in the ignition stage in a CVC application, such as the effect of the dilution by a residual burned gas (RBG), the turbulence intensity, and turbulence length scales. • For this purpose, a lab-scale facility was developed to generate turbulent flow and to allow electrical energy measurements. The setup will allow a well-controlled flow, with the possibility to vary the mean velocity and turbulent scales. The ignition system's energy and power effects on the ignition process will be studied. Definition of RBG composition • In order to define the composition of the synthetic RBG, the main flame properties were analyzed (𝑇𝑏, 𝑆𝐿, 𝛿) • Mixture: Propane/air - 𝜙= 0,7, P = 1 bar and 2 bar and ambient temperature. • The calculations were made using Cantera with the San Diego chemical mechanism [1]. • The mixture chosen was so that the heat release from the RBG produced would be the same. • Synthetic RBG dilution mixture chosen: 5% He + 95% N2 (without H2O). • A mixture of 5% He + 95% N2 is adequate and behaves as a residual burned gas. • The perforated plate design describes the desired turbulence intensity profile. • Optical diagnostics will be made to characterize the turbulence and ignition in the chamber. • MIE [1] measurements will be performed for a propane/air mixture with synthetic RBG dilution. with the new turbulence generator. • For spark duration lower than 0.4 ms, a smaller calorimetry chamber could be used. References [1] Chemical - Kinetic Mechanisms for Combustion Applications, San Diego Mechanism web page, Mechanical and Aerospace Engineering (Combustion Research), University of California at San Diego. http://combustion.ucsd.edu [2] R. le Dortz, “Détermination des caractéristiques fondamentales de combustion de pré-mélange air-kérosène, de l’allumage à la vitesse de flamme : représentativité de surrogates mono et multi-composants.” Thesis. Ecole nationale supérieure de mécanique et d'aérotechnique. [3] N. Mazellier, L. Danaila, and B. Renou, “Multi-scale energy injection: A new tool to generate intense homogeneous and isotropic turbulence for premixed combustion,” Journal of Turbulence, vol. 11, pp. 1–30, 2010, doi: 10.1080/14685248.2010.519708. [4] C. C. Huang, S. S. Shy, C. C. Liu, and Y. Y. Yan, "A transition on minimum ignition energy for lean turbulent methane combustion in flamelet and distributed regimes," Proceedings of the Combustion Institute, vol. 31 I, no. 1, pp. 1401–1409, 2007, doi: 10.1016/j.proci.2006.08.024. [5] C. J. BENITO PAREJO. “Experimental Characterization of Electrical Discharges and Formation of the Ignition Kernel. Application to the Study of Performances of Aeronautical Igniters”. 2019. Thesis. Ecole n	poster
1Biomedical Center, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany; 2John Curtis School of Medical Research, Australian National University, Canberra, Australia.3Center for Integrated Protein Science Munich, Department of Chemistry, Munich, Germany Splicing factor Scaf6/CHERP regulates muscle development in Drosophila Shao-Yen Kao1, Keshika Ravichandran1, Rippei Hayashi2, and Maria Spletter1,3 2. Scaf6/DmCHERP is conserved among species D. melanogaster SCAF6 D. rerio CHERP M. musculus CHERP H. sapiens CHERP SWAP RPR RS domain G-parch 3. Scaf6 is expressed in ﬂy ﬂight muscle (IFM) and neuron nucleus 500 400 1000 1500 RC RA RE 30hr APF 72hr APF 1d Adult Age: Scaf6-PA Scaf6-PE Scaf6-PC RT-PCR in IFM Actin, DAPI, Myc-Scaf6 30hr APF 72hr APF 1d Adult RT-PCR in Neuron Elav, DAPI, Myc-Scaf6 Overexpression in neuron Overexpression in IFM 0 10 20 30 40 50 60 70 80 90 100 Survival Righting reflex Climbing Flight Grooming Performance percentage WT Scaf6 Mutant Mef2> Scaf6-IR Elav> Scaf6-IR Mef2, Elav>Scaf6-IR Actin5C>Scaf6-IR Tublin>Scaf6-IR 4. Tissue-type selectivity of Scaf6 function in ﬂy Lethal in pupa stage WT Scaf6 Mutant Mef2> scaf6-IR WT Scaf6 Mutant Mef2> scaf6-IR 0 1 2 3 4 Micron Sarcomere length 48hr APF 72hr APF WT Scaf6 MT Mef2> IR Flight muscle 48hr 72hr WT Scaf6 MT Mef2>IR *** p=0.06 5. Scaf6 is necessary for ﬂight muscle b. Scaf6 regulates myoﬁbril development a. Scaf6 knockdown in myoblast loss muscle ﬁbers (Nikonova and Kao, 2019) 1. RNA binding proteins in muscle 6. Scaf6 regulates splicing in IFM muscle Selected GO enrichments a. Scaf6 regulates alternative splicing Mhc Mhc WT Mutant Mef2> W- Mef2>scaf6-IR Zasp66 WT Mutant 0 36 73 110 146 Zasp66 Mef2> W- Mef2>scaf6-IR Intron retention Exon usage changes c. Selected target gene expression at protein level in Scaf6 mutant b. Spliced junction changes in Scaf6 mutant Novel spliced event Sls WT Mutant RT-PCR of veriﬁcation Sls novel event 500bp 100bp DNA control WT Scaf6 Mutant Thorax Thorax Head Head • Scaf6 plays functional roles in muscle and nervous system in selective perspectives • Scaf6 functions in myoblast and myofibril development • Scaf6 regulates RNA splicing dynamic in developing IFM and repress intron retention • Tell me know what your thought!! Contact me: shao-yen.kao@bmc.med.lmu.de Conclusion: 7. LOF of Scaf6 impaired developing muscle contraction WT Scaf6 Mutant 48hr APF time 0.0s time +1.2s no movement n=27 WT Scaf6 Mutant % Muscle twitch n=18 0 10 20 30 40 50 60 70 80 90 100 WT Scaf6 Mutant Mef2>IR 1151>IR Him>IR Salm>Scaf6-IR # of muscle ﬁber 6 5 4 3 (%) 1151, Him: Myoblast speciﬁc; Salm: after 24hr APF (Muscle driver) (Neuron driver) APF: After puparium formation Whole body (Muslce+Neuron?) Neuron Neuron Neuron>Muscle Muscle>Neuron	poster
Getting streamlined elaboration of feature tables with separated quality controls, advanced statistics such as linear model with mixed effects, and more: presenting the “GetFeatistics” R-package Gianfranco Frigerio1,2,3 1 Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy 2 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg 3 Department of Clinical Sciences and Community Health, University of Milan, and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy 20th Annual Conference of the Metabolomics Society – METABOLOMICS 2024 – Osaka, Japan, 16th -20th June 2024 The package is on GitHub: https://github.com/FrigerioGianfranco/GetFeatistics I acknowledge Albina Rastoder for helping with the testing of some functions, during her 2 months internship at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg. I also acknowledge Prof. Dr. Emma Schymanski for the support and suggestions and the entire Environmental Cheminformatics group of the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg for the help and feedback. I acknowledge funding support from the Luxembourg National Research Fund (FNR) for project A18/BM/12341006. frigerio.gianfranco@hsr.it Any questions? Write me!!! ☺ Gianfranco Frigerio @gianfrancofrig1 Gianfranco Frigerio Within the metabolomics community, tools such as MS-DIAL and R-based algorithms as XCMS are widely implemented to convert raw data to feature tables. As demonstrated in a previous work, while conducting non-targeted metabolomics studies with defined groups of subjects assessing variations of molecules present at low concentrations (such as metabolites of exogenous compounds) the use of separated pooled quality control (QC) samples can be a promising strategy to both improve the quality of the dataset and preserving potential features deriving from low concentrated molecules. Moreover, in observational epidemiologic studies, controlling for confounding factors is crucial to assess the association of metabolite variations with the biological question of interest; also, for longitudinal studies, linear models with mixed effects are a great statistical approach. Targeted analyses Non-targeted analyses featTable featINFO get_feat_info_from_MSDial • featTable: table with feature intensities • featINFO: table with rt, m/z and potential annotations get_targeted_elaboration Given a tables containing data from targeted analyses, including a calibration curve and internal standards, it calculates the concentrations in unknown samples. test_normality_density_plot test_normality_q_q_plot test_normality_saphiro_table transf_data To replace missing values, log-transform, and/or scale the data. gentab_P.1wayANOVA_posthocTurkeyHSD It performs one-way ANOVA, with also TurkeyHSD posthoc tests for between-groups comparison, to each desired variable and creates a new table with the p-values gentab_P.2wayANOVA_posthocTurkeyHSD It performs 2-way ANOVA, with also TurkeyHSD posthoc tests for between groups comparison, to each desired variable and creates a new table with the p-values addINFO_to_table Given a table containing data related to features (for example the output of a statistical analyses) and the related featINFO table, it combines everything in a single table. It removes special characters from a character vector Given a dataframe and a set of dependent and independent variables from that dataframe, it generates a linear regression model for each single dependent variable and creates a new table with all slopes and p-values. plot_calibration_curves It creates plots of the calibration curves from a targeted elaboration. Statistical analyses Functions to test normality, by producing density plot, q-q-plot and performing Shapiro test get_feat_info_from_patRoon get_feat_table_from_MSDial get_feat_table_from_patRoon From MS-DIAL output or from patRoon output, it	poster
Public Health, Markets and Law Call for abstracts COMPHACRISIS is pleased to announce the Public Health, Markets and Law workshop, which will be held on Friday, 29 September 2023, at UCD Sutherland School of Law, Dublin. This workshop aims to bring together experts from different disciplines, including economics, law, marketing, political economy, public health and sociology, to discuss and share their perspectives and insights on public health, markets and law. Keynote: Ms Anna Vernet (EU Commission Head of Unit, Antitrust, Pharma and Health Services) Confirmed Speakers and Chairs: • Professor Susie Geiger (UCD College of Business) • Dr Łukasz Grzejdziak (University of Strathclyde) • Dr Cliona Kelly (UCD Sutherland School of Law) • Professor Cecily Kelleher (UCD College of Health and Agricultural Sciences) • Dr Mary Catherine Lucey (UCD Sutherland School of Law) • Professor Aisling McMahon (Maynooth University) • Dr Enrique Sanjuán y Muñoz (Court of Appeal of Málaga)) • Dr Carmen de Vivero de Porras (Universidad de Málaga) • Professor Helen Roche (UCD Vice President for Research, Innovation and Impact ) Organisers: Dr Mina Hosseini and Professor Imelda Maher We invite submissions that address the following themes: • Competition law and health markets • Exploring the EU pharmaceutical sector through a multidisciplinary lens • Intellectual property law and public health • Legal and regulatory responses to the COVID-19 Pandemic • Future of health markets • A multidisciplinary perspective on the pharmaceutical strategy for Europe or any other research issue in this area Papers should be original, not previously published or under consideration for publication elsewhere. We welcome abstracts from researchers at all stages of their careers, including early career researchers and PhD students.	poster
What Came First: The Paper or the Data? Measuring data reuse and metadata re-curation is important for understanding and finding examples of repository behaviors. Comparing connected article and dataset publication dates may provide helpful measures and visualizations. These connection timelines are for repositories holding datasets that are connected to articles that acknowledge funding by NSF. They provide a limited view that may not be representative of the entire repository. Data retrieval and processing are described here. Reuse occurs when data exists before articles referencing it are published. In these cases the connection median difference (y-axis) is above 0. Curation occurs when data and articles are published at the same time. In these cases the connection median difference (y-axis) is 0. Re-Curation occurs when articles exist before the data they reference gets a DOI. In these cases the connection median difference (y-axis) is below 0. Data from CHORUS (https://www.chorusaccess.org) Funded by the U.S. National Science Foundation, award 2134956 Ted Habermann, Erin Robinson, Metadata Game Changers	poster
The analysis of 3C 47 has resolved a longstanding conundrum dating back to the 1990s: the CIVλ1549 broad- line profile in the UV spectra of radio galaxies often appeared as narrow as or narrower than the Hβ line. The interpretation provided by 3C 47, involving an accretion disk and a failed wind, offers an explanation. In many cases, the disk contribution could be completely masked. The “double-peakers,” which are most frequently found at the extremum of the Eddington ratio (minimum radiative output per unit mass) on the quasar main sequence, may all be due to the trimming of the emitting region by a second black hole. Accretion disk and wind emission in the Population B, jetted quasar 3C 47 Paola Marziani1, Shimeles Terefe Mengistue2,3,4, A. del Olmo5, M. Povic5,6, J. Perea5, and A. Deconto Machado5 1National Inst. for Astrophysics (INAF), Oss. Astron. di Padova, Padova, Italy; 2Space Science and Geospatial Inst. (SSGI), Addis Ababa, Ethiopia; 3Addis Ababa Univ., Addis Ababa, Ethiopia; 4Jimma Univ., Jimma, Ethiopia; 5IAA (CSIC), Granada Spain; 6Mbarara Univ. of Science and Technology (MUST), Mbarara, Uganda An optically thick, geometrically thin accretion disk around a supermassive black hole might contribute to broad line emission in type-1 active galactic nuclei (AGN). We show that the double-peaked profiles of the strongest low-ionization lines (LILs) in the 3C 47 optical spectrum can be explained by a relativistic Keplerian accretion disk model. The profiles of prototypical high ionization lines (HILs) such as CIVλ1549 were also modeled by the contribution of the accretion disk, but required an additional component, possibly due to a failed wind. The observations of 3C 47 suggest an intriguing hypothesis for the origin of the “double-peakers,” sources found at the low end of radiative power per unit black hole mass along the quasar main sequence. Intriguing profile variability Conclusion A binary black hole, after all? Relativistic accretion disk plus a failed wind? 𝛺 𝛺 30 kpc Orbital plane of the secondary Equatorial plane of the primary Reference 3C47 The double-peaked profile of Balmer lines is modeled using a relativistic AD emission profile, following the approach of Chen & Halpern (1989, ApJ, 344, 115), and using a fully Bayesian technique. The single-peaked CIVλ1549 profile can be attributed to the AD plus a strong central feature. The flat spectral energy distribution of 3C 47, dominated by synchrotron and synchrotron-self-Compton emission, results in the over-ionization of the gas. This over-ionization leads to a lower force multiplier, which may contribute to the formation of a failed wind. Force multiplier 3C 47 Typical AGN The available observations, though sparse, reveal intriguing variability patterns and changes in peak shift amplitude. The periods inferred from these shift variations suggest masses exceeding that of the primary black hole. The hypothesis that the double-peaked structure is due to two black holes, each with its own broad line region giving rise to an almost Gaussian component, is not favored. The VLA radio map (Fernini et al. 1991, ApJ, 381, 63) shows an intriguing misalignment between the hot spot and the lobe- counter-lobe axis. The geodetic precession period can be shorter than, or comparable to, the dynamical timescale of the radio source, if precession is induced by a second, smaller- mass black hole between the outer disk edge (r ~ 103 rg) and the torus inner edge(r ~ 104 rg), with an orbital plane inclined by 15o with respect to the equatorial plane of the primary. AD AD+failed wind Ionization structure MBH ~ 7 109 M⦿ tdyn ~ 6 107yr	poster
Helping researchers get started with Patient Engagement (PE) Observation  Implementation Increases the quality, patient relevance and societal acceptance of research and its results Empowers patients and therefore impacts their well-being Potentially increases eligibility for a funding grant To help researchers get started with PE a special “Starter Pack” compiled One central place for all researchers’ PE needs Already existing information is curated and organised in an easy-to-find way Feedback from researchers is that it’s difficult to understand where to begin Multitude of resources out there is overwhelming and makes it complicated to navigate the subject Resources out there exist in silos and are fragmented patient-engagement.eu Ask a question Submit a resource Help us disseminate Watch video stories Patient Engagement Resource Centre (PERC) is developed with the funding from EATRIS-Plus Project (GA No 871096). It has been developed jointly between the European Infrastructure for Translational Medicine (EATRIS), the European Patients’ Forum (EPF) and the European AIDS Treatment Group (EATG). The PERC is intended as guidance and should be considered as advice only. Video Stories Get involved PE in basic science of lung fibrosis developed workshops to improve bilateral understanding PE in rare progressive liver disease (PSC) organised workshops on knowledge sharing & manuscript co- developed PE in rare ovarian tumours fundamental collaboration in bridging the gap in understanding and triggering scientific breakthroughs Why Patient Engagement? Resources This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 871096 Developed by	poster
This project has received funding from the European Union‘s Horizon 2020 research and innovation programme under grant agreement No731031. operas-eu.org pierre.mounier@openedition.org Created by Elisabeth Heinemann Digital Humanities Officer at Max Weber Stiftung OPERAS Communication Officer 300 geistes- & sozialwissenschaftl. Verlage 20 000 wisenschaftliche BloggerInnen 1 200 geistes- & sozialwissenschaftl. Journals OPERAS ist eine Forschungsinfra- struktur für offene Wissenschafts praxis in den Sozial- und Geistes wissenschaften in Europa. OPERAS bringt 38 Organisationen aus 15 Ländern zusammen und wird von 9 Core Group-Partnern koordiniert. Die Leitung liegt bei OpenEdition und Huma Num (FR). © infographics: Laetitia Martin Pierre Mounier Associate Director at OpenEdition Coordinator of OPERAS Creative Commons Attribution 4.0 International CC BY 4.0 Die europäische Publikationslandschaft wird von vielen Einzelakteuren ohne Koordination gestaltet. Ein großer Teil der Forschungszeit in den Geistes- und Sozialwissenschaften widmet sich dem Lesen, Annotieren und Schreiben wissenschaftlicher Literatur. OPERAS bringt WissenschaftlerInnen, Bibliotheken und Verlage zusammen, um eine gemeinsame pan-europäische Forschungsinfrastruktur aufzubauen und so die Publikationslandschaft und den wissenschaftlichen Austausch für Forschende zu verbessern. Netherlands Hypothesis Linguistics in Open Access – LingOA OAPEN Quality Open Access Market – QOAM August 2018 United Kingdom KU Research Open Books Publishers Open Library of Humanities – OLH Ubiquity Press UCL Press France Huma Num OpenEdition Core Group Greece National Documentation Centre – EKT/NHRF Croatia University of Zadar University of Zagreb, University Computing Centre – SRCE Poland Institute of Literary Research of the Polish Academy of Sciences – IBL PAN Germany Georg-August-University Göttingen – UGOE Knowledge Unlatched – KU Max Weber Stiftung – MWS Scientific Electronic Library Online – SciELO Luxembourg Luxembourg Centre for Contemporary and Digital History – C²DH Association of European Uni versity Presses – AEUP Belgium University of Liège Italy Associazione Italiana per la promozione della scienza aperta – AISA Conference of Italian University Rectors – CRUI Italian National Research Council – CNR Lexis Compagnia Editoriale Napoli University Federico II Roma Tre University University Ca‘Foscari Venice University of Milan University of Turin – UniTo Portugal NOVA School of Social Sciences and Hu manities University of Coimbra University Institute of Lisbon – ISCTE-IUL Slovenia The Research Center of the Slovenian Academy of Sciences and Arts – ZRC SAZU University of Ljubljana, Faculty of Arts Sweden Stockholm University Library Norway UiT The Arctic University of Norway	poster
Towards a neurocomputational model of the actor-strategy in language comprehension Phillip Alday Matthias Schlesewsky Ina Bornkessel-Schlesewsky Live code at https://bitbucket.org/palday/ginnungagap-code Motivation: The Actor Heuristic Neurophysiological data from typologically diverse languages provide evidence for an actor-based interpretation strategy in language comprehension[1]. The search for an actor depends on a number of prominence scales: person, case, animacy, position, number and deﬁniteness. Actor Space The two arguments in a transitive construction are “pulled” toward or “pushed” away from actorhood by the weight of the individual features. Distinctness between arguments corresponds to distance in the actor space. Argument Prominence prominence distorts the space into attractor basins prominence distorts the space into respulsor hills actorhood follows prominence Weighting Inﬂuences Each prominence scale is subject to a language-speciﬁc weighting. This weighting serves to distort the actor space, increasing or decreasing the relative inﬂuence of speciﬁc prominence features. For example, case is stronger in German than word order, while in English the weight of word order is so extreme that the other scales are largely irrelevant. Aims Here, we sought to quantify the relative weights of the prominence scales and compare this against various proposed metrics in actor space. We used linear mixed models to examine the predictive power of each metric for ﬁxed factors (prominence scales) for human EEG while compensating for subject and item (lexical) variation. Computational Model We implemented an initial quantiﬁcation of the actor heuristic. Weights were estimated with the help of existing research[2]. There are three metrics for measuring distinctness, or diﬀerence in prominence. metric formula description dist P i \|NP2i −NP1i\| Manhattan distance (feature overlap) signdist P i (NP2i −NP1i) pairwise diﬀerence (signed, unweighted diﬀerence) sdiﬀ ⃗w · ⃗ NP2 −⃗w · ⃗ NP1 scalar diﬀerence of weighted prominences Prominence Hierarchies Feature Hierarchy Person: First = 1 > Other = 0 Case: Nominative = 1 > Accusative = -1 Animacy: Animate = 1 > Inanimate = 0 Position: Early = 1 > Late = 0 Number: Singular = 1 > Plural = 0 Deﬁniteness: Deﬁnite = 1 > Indeﬁnite = 0 Materials and Design 2x2x2x2 design with 60 lexical items; every condition appeared for each lexical item. Word Order Ambiguity NP1-Type NP2-Type Subject ﬁrst × Ambiguous × Noun × Noun Object ﬁrst Unambiguous Pronoun Pronoun 25 Ag/AgCl electrodes @ 250 Hz 37 German native speakers (20 women) 400ms for single words, 500ms for phrases, 100 ms ISI EEG Data NP2 noun NP2 pronoun FCZ CPZ PZ N400 P600 FCZ CPZ PZ N400 P600 0.5 1.0 −4 4 s µV Grand average ERPs triggered at the on- set of NP2 for the ambiguous condition. Blue = subject (actor) initial, Red = object ini- tial; solid = noun, dashed = pronoun for NP1. Model Data dist signdist sdiﬀ N400 P600 Mean EEG (restricted to the left posterior ROI) in each time window as a function of the diﬀerent metrics (centered) and its interaction with ambiguity. The colors indicate the “height”, i.e., a range of (predicted) values of the mean EEG. More color indicates more variation. Metric Performance Likelihood ratio test for models in the N400 time window with NP1 ambiguous. A linear mixed model of the form mean ~ c.(metric) + (1 \| item) + (1 \| subj), was calculated with lme4[3]. Df AIC logLik Chisq Chi Df Pr(Chisq) dist: 5 197812 -98901.48 signdist: 5 197740 -98865.21 0.00 0 1 sdiﬀ: 5 197596 -98793.06 216.84 0 <2.2e-16*** Discussion All three metrics show some potential; however, sdiff performs signiﬁcantly better than signdist (which performs better than dist). The signedness of signdist allows for conditional prediction — hence the diﬀerent color scale in the ambiguity condition above. The gradience of sdiff allows for much more precise predictions, which is reﬂected in the subtlety present in the respective color scale. Sample	poster
Calibration Strategy of JUNO Junting Huang for the JUNO Collaboration School of Physics and Astronomy, Shanghai Jiao Tong University junting@sjtu.edu.cn JUNO Experiment Liquid Scintillator Non-Linearity Calibration Calibration System liquid scintillator non-linearity: Birks’ law, Cherenkov light gamma calibration sources at different energies treat a gamma event as a collection of e- and e+ using Geant4 build a non-linearity model for e-/e+, fit to calibration data predict the non-linearity for e+ constraint from continuous spectra from cosmogenic B12 and C11 Jiangmen Underground Neutrino Experiment (JUNO) neutrino mass ordering measurement precision measurement of \|∆𝑚ଷଵ ଶ\|, ∆𝑚ଶଵ ଶand 𝜃ଵଶ calibration goal: for uniformly distributed e+ events better than 1% energy calibration precision better than 3% energy resolution at 1 MeV 17612 20-inch PMTs, 25600 3-inch PMTs, 78 % photocathode coverage Non-Uniformity Calibration 20-inch PMT Calibration Automatic Calibration Unit Cable Loop System Guide Tube Calibration System Remotely Operated Vehicle dark noise, time alignment, gain calibration first hit time vs. charge relative photon detection efficiency 20-inch PMT non-linearity: electronics, waveform reconstruction use 266 nm laser to inject light on a Teflon ball at detector center 3-inch PMTs working in digital mode: fired or non-fired Poisson-zero method: use the number of non-fired 3-inch PMTs to calibrate laser intensity source type energy 137Cs 𝛾 0.662 MeV 54Mn 𝛾 0.835 MeV 60Co 𝛾 1.173 + 1.333 MeV 40K 𝛾 1.461 MeV 68Ge 𝛾 0.511 + 0.511 MeV 241Am-Be n, 𝛾 n + 4.43 MeV (12C) 241Am-13C n, 𝛾 n + 6.13 MeV (16O) (𝑛, 𝛾)𝑝 𝛾 2.22 MeV (𝑛, 𝛾) C ଵଶ 𝛾 4.94 MeV or 3.68 + 1.26 MeV detector non-uniformity: PMT acceptance, light attenuation, total internal reflection at the acrylic-water interface calibration sources deployed by the calibration system at different positions in the detector cosmogenic neutrons, about 1 M / week develop reconstruction algorithms that use these calibration data as input to largely remove the detector non-uniformity Positron Energy Resolution Calibration use the e+/e- nonlinearity model to predict resolution curve for e+ further parametrize the resolution curve with 𝜎/𝐸= 𝑎ଶ/𝐸+ 𝑏ଶ+ 𝑐ଶ/𝐸ଶ contributing factors: a: Poisson, b: non-uniformity and Cherenkov, c: mainly dark current and e+ annihilation References: JHEP 03 (2021) 004, F. Zhang PhD thesis (2021), Chin.Phys.C 46 (2022) 12, 123001, arXiv:2405.18008 + low energy sources: 226Rn, 241Am, etc.	poster
Emma Osbiston, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon OX11 0DE R03: A Raspberry Pi Tomography Beamline controlled through Twitter In order to conduct experiments at Diamond Light Source, all of the beamlines utilise Diamond’s “Generic Data Acquisiton” software, GDA. This software allows the control of the experimental environment, by updating parameters such as the sample position, and collection of experimental data for analysis. In 2016 it was proven that GDA could run on a Raspberry Pi, a popular single-board computer the size of a credit card. This allowed the Raspberry Pi to conduct scans at the same software level as any other beamline at Diamond Light Source. For more information please visit www.diamond.ac.uk, www.twitter.com/diamondrpi or contact james.mudd@diamond.ac.uk 1. Introduction 5. Hardware & Scannables 6. Beamline Process 4. The API 3. Tomography Acknowledgments • An application programming interface (API) is a way of controlling communications between different softwares within a system – to the user, it will only accept specific inputs, and can return appropriate outputs. • To create the API used to control all of the devices and processes on the beamline, I used a development tool called Node-RED, which is a Raspberry Pi optimised visual interface for Node.js, an asynchronous, event-driven runtime for Javascript. The use of Node-RED required me to write functions in Javascript but greatly simplified the process compared with if I had used Node.js alone. Flows are stored in JSON format meaning to best view them Node-RED is needed (see the Github link below). Once a scan is requested via Twitter, Node-RED can then either choose to store or work with this information in Javascript; sample number is found through parsing the tweet string. This information is then passed through a flow of processes which can be seen in section six of this poster, with Node-RED controlling all of the communication between the processes. the outputs are 3D models, but with no internal features visible, as the light was not able to penetrate through the material to view it. The turntable is used to rotate the sample to different orientations, and these orientations are all captured as 2D images by the camera. Savu is the part of the process that takes these 2D images and converts them into a 3D tomogram. (Image by Dtrx used under Creative Commons Attribution-Share Alike 3.0 Germany License) Tomography is an imaging method that uses 2D images to build up a 3D model of a sample. By taking images of a sample using a penetrating light source (X-rays at Diamond) at different orientations, these can be spliced together using a mathematical procedure called tomographic reconstruction to give a 3D rendering of both the interior and exterior structure of the sample. As R03 uses visible light, the beam cannot penetrate the samples, meaning that the reconstructions are more of a demonstration of tomography than real tomography – 7. Conclusions • I would like to thank my supervisor James Mudd, as well as Peter Holloway, Mark Basham and Jacob Filik and the rest of the Data Acquisition Team for all their help and invaluable contributions. • Thanks to Ben Seeley, who wrote the initial configuration for GDA for RPi in 2016 and provided the starting point for this project. • Thanks also to Sam Elford, for creating custom parts for the project. • Finally I’d like to say thank you to everyone at Diamond Light Source who helped me with this project in numerous different ways. • The R03 beamline successfully demonstrates some of the processes used to conduct experiments on beamlines at Diamond Light Source • It is able to run beamline software from the main branch that aptly demonstrates the flexibility of the software, particularly GDA, which controls the hardware. • The Twitter interface works as an effective outreach tool. • It may be beneficial to split the processing across multiple Raspberry Pis as processes su	poster
C. Snodgrass1, J. Skottfelt2, C. Mackay3, M. Dominik4 and the GravityCam Consortium 1 Institute for Astronomy, University of Edinburgh, UK. csn@roe.ac.uk 2 Centre for Electronic Imaging, The Open University, Milton Keynes, UK, 3 Institute for Astronomy, University of Cambridge, UK, 4 Centre for Exoplanet Science, SUPA School of Physics & Astronomy, University of St Andrews, UK GravityCam: A wide-field high-resolution imager for the NTT Other scientific applications 1. Einstein, A., “Erklarung der perihelbewegung des merkur aus der allgemeinen relativitatstheorie“, Sitzungsber. Kgl. Preuss. Akad. Wiss. , 831{839 (1915). 2. Paczynski, B., “Gravitational microlensing by the galactic halo”, ApJ 304, 1{5 (May 1986). 3. Bennett, D. P. and Rhie, S. H., “Simulation of a Space-based Microlensing Survey for Terrestrial Extrasolar Planets”, ApJ 574, 985{1003 (Aug. 2002). 4. OGLE-IV http://ogle.astrouw.edu.pl 5. Beaulieu, J. P. et al. , “Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing”, Nature 439, 437{440 (Jan. 2006). 6. Ivezic, Z. et al., “LSST: from Science Drivers to Reference Design and Anticipated Data Products”, ArXiv e-prints (May 2008). 7. Baldwin, J. E. et al., “Difraction limited 800 nm imaging with the 2.56 m Nordic Optical Telescope”, A&A 368, L1-L4 (Mar. 2001). 8. Mackay, C. D. et al., “Subelectron read noise at MHz pixel rates”, Proc. SPIE 4306, 289{298 (May 2001). Abstract With its high frame-rate and wide-field, GravityCam can: • Provide a unique database for optical variability • stellar variability and asteroseismology • sub-second variability from accretion onto compact objects • Explore galactic star clusters • detection of tight binaries and their eclipse features • proper motion measurements for kinematic studies • Trace Dark Matter in the Universe through weak gravitational lensing • Study Solar System objects • resolve the orbits of binary asteroids • discovery of small bodies in the Kuiper Belt and Oort Cloud. We have developed a new concept for a ground-based imaging instrument called GravityCam, capable of delivering significantly sharper images from the ground than is normally possible without adaptive optics. Images recorded at high speed can be aligned before combination and can yield a 2-3 fold improvement in image resolution, or be used separately for high-cadence photometry. Very wide survey fields are possible with wide-field telescope optics. GravityCam is proposed to be installed at the NTT, where it will enable detection of Earth sized planets by gravitational microlensing and weak shear studies of dark matter distribution in distant clusters of galaxies, produce a vast dataset for asteroseismology and stellar variability, and help us understand the population of the Kuiper belt and the Oort cloud via stellar occultations. Lucky Imaging Next steps Gravitational microlensing1,2 is the only way to obtain population statistics of cool low-mass exoplanets and exomoons. A GravityCam microlensing survey will provide sensitivity down to Lunar mass, a territory widely considered to be reserved for space missions like WFIRST3. High spatial resolution means that it will be sensitive to fainter source stars and thereby be able to detect planets 100 less massive than what is possible with the current state-of-the-art survey OGLE-IV4. Detecting lunar-mass exoplanets GravityCam will detect planets that are virtually undetectable by other methods. This figure shows the planets detected to date where we see that for planets of Earth-mass and below detections are very few though we expect there are vast numbers of them. Lucky Imaging6,7 takes images rapidly (10-30 Hz) and aligns them, almost completely eliminating the tip-tilt distortions caused by atmospheric turbulence, improving the median seeing by a factor between 2.5 and 3. If we use a small fraction of the images and add the sharpest ones together we find that image resolution is improved further to a total of a factor of 4 wit	poster
Application of Exopolymeric Substances and Biosurfactants in removal of heavy metals in Qatari soil and water Najla Alkorbi, Zulfa Al Disi, Mohammad AlGhouti and Nabil Zouari Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts Sciences, Qatar University, P.O. Box 2713, Doha, Qatar Heavy metals are economically important for industrial applications, but they are significant pollutants for the environment. The pollution with heavy metals causes serious threats to all living organisms in any ecosystem, due to their toxicity at low concentrations, their bioaccumulation and non-biodegradability in the environment. Advancements in biotechnology led to huge developments in the bioremediation approaches. In this study the effectiveness of biosurfactant’s and extracellular substance EPS of three selected strains, isolated from sabkha and soils in Qatar and characterized in our laboratory, in the removal of heavy metals from highly weathered oil- contaminated soils were investigated. One Mineral forming strains Virgibacillus martsimiure (DF112) and two hydrocarbon-degrading bacterial strains Pseudomonas aeruginosa (SH1) and Bacillus subtilis (SA28) were used to produce EPS and biosurfactants. The FTIR analysis confirmed alterations in the functional groups’ compositions after soil washing. Moreover, the ICP-OEC confirmed variable removal efficiencies of heavy metals. The best heavy metal removal efficiency (%) was obtained when washing with 10% of the biosurfactant produced by Pseudomonas aeruginosa (SH1). These results would help in the application of EPS and biosurfactants for the removal of heavy metals through washing of contaminated soils. Keywords: Sabkha, Biosurfactants, EPS, Heavy metals, weathered contaminated soils.	poster
Comparative Analysis of Inclusion Criteria of Journal Blacklists and Whitelists Michaela Strinzel, Anna Severin, Matthias Egger und Katrin Milzow Swiss National Science Foundation Background •Journal Blacklists (BL) and Whitelists (WL) aim to capture the legitimacy, quality and transparency of scientific journals[1]. •With the emergence of Predatory Journals BL and WL are increasingly conculted by scholars in their search for publication outlets [2]. •While there is doubt over the objectivity, reliability and transparency of BL and WL [3], these lists and their inclusion criteria have not yet been analysed systematically. Aim Systematic comparison of inclusion criteria and contents (journals and publishers) of journal BL and WL •Aim: Identify and understand indicators of legitimacy, quality and transparency in scholarly publishing •Aim: Point out the scientific community's expectations towards legitimacy, quality and transparency Methods Qualitative coding and comparative analysis of 198 inclusion criteria of 2 BL (Beall's List and Cabell's International) and 2 WL (DOAJ and Cabell's International) on 3 levels: •Subject Matter: To what aspect of a scientific journal does the inlcusion criterion relate? •Informative Function: Does the criterion relate to (1) Quality, (2) Transparency, (3) Legitimacy, or (4) Establishing Stage of a scientific journal? • Verifiability: How easy is it to verify a criterion? Comparison of BL and WL in terms of their contents (e.g. journals and publishers) making use of the Jaro-Winkler Distance. Illustration of overlaps with Venn diagrams. Results Image 1: Subject Matter Image 1: Informative function Image 3: Overlaps between the BL Beall’s List of Publishers and the WL DOAJ Lists Transparency Quality Degree of Establishment Legitimacy BL 3 2.4 2.5 2.1 WL 3 2.4 2 1.7 Tabelle 1: Verifiability of inclusion criteria by informative function in average. (Rated on a scale from 1=hard bis 3=easy) Contact Information •Swiss National Science Foundation: http://www.snf.ch •E-Mail: michaela.strinzel@snf.ch; anna.severin@snf.ch Explanation of Results •Subject Matter BL put focus on Business Practices and Quality Control of journals, while WL stress Quality Control and Policies •Informative Function BL: Most inclusion criteria give information regarding Integrity and Legitimacy of a journal or publisher. WL: Most inclusion criteria provide information on Transparency. • Verifiability Overall, inclusion criteria can be said to be verifiable. There are, however, significant differences in verifiability across inclusion criteria of different informative functions. • Comparison of BL and WL contents Content overlaps between BL and WL (here: publisher in Beall’s List and in DOAJ) is relatively small. Conclusions Methdologically, it proved feasible to classify and systematically compare inclusion criteria and contents of BL and WL. In terms of their subject matter and informative function, BL and WL seem to complement one another. As such, BL and WL serve different purposes. This is reflected in the small content overlaps between the two types of journal lists. Our systematic classification and comparison of inclusion criteria can help to develop a more holistic understanding of quality, legitimacy and transparency in scholarly publishing. References [1] Vence, T. (2017). On Blacklists and Whitelists. The Scientist. [2] Swauger, S. (2017). Open access, power, and privilege: A response to ’What I learned from predatory publishing.’ College & Research Libraries 78:11. [3] Olivarez et al. (2018). Format Aside: Applying Beall’s Criteria to Assess the Predatory Nature of both OA and Non-OA Library and Information Science Journals. College & Research Libraries, 79:1. This work is accessible and can be shared and adapted under the Creative Commons (CC) license (CC BY 4.0).	poster
In silico toxicology services for nanoparticle risk assessment C. Helma, D. Gebele, M. Rautenberg in silico toxicology gmbh, Basel, Switzerland Contact: support@in-silico.ch. Information: www.in-silico.ch in silico toxicology gmbh - Rastatterstrasse 41 - CH-4057 Basel, Switzerland http://enanomapper.net This project has received funding from the European Union’s Sev- enth Framework Programme for research, tech- nological development and demonstration under grant agreement no 604134. Abstract During the eNanoMapper project in silico toxicologies (IST) public server infrastructure was adapted to the requirements of the eNanoMapper project and augmented with new developments. This poster gives a comprehensive overview of all IST resources developed within eNanoMapper. Each service is presented with a brief description and links to the public interface, source code, documentation and download links for self-contained docker images. lazar lazar[1] is a framework for read-across predictions. Within eNanoMapper lazar was extended with interfaces for the eNanoMapper infrastructure and capabilities to predict nanomaterial toxicities. ▶lazar source code [2] https://github.com/opentox/lazar ▶lazar Ruby gem library https://rubygems.org/gems/lazar ▶lazar issue tracker https://github.com/opentox/lazar/issues ▶lazar methodology and validation https://github.com/enanomapper/ nano-lazar-paper/blob/master/nano-lazar.pdf ▶lazar tutorial https://github.com/opentox/lazar/blob/master/README.md ▶lazar API documentation http://www.rubydoc.info/gems/lazar nano-lazar The nano-lazar GUI provides a public webinterface for nano-lazar models. ▶nano-lazar public webinterface [3] https://nano-lazar.in-silico.ch ▶nano-lazar source code https://github.com/eNanoMapper/nano-lazar ▶nano-lazar Ruby gem library https://rubygems.org/gems/nano-lazar ▶nano-lazar issue tracker https://github.com/eNanoMapper/nano-lazar/issues ▶nano-lazar API documentation http://www.rubydoc.info/gems/nano-lazar ▶nano-lazar dockerized service on Docker Hub https://hub.docker.com/u/insilicotox/nano-lazar nano-lazar-paper Detailed description of nano-lazar methods and validation results [4]. Results can be reproduced by external researchers with the accompanying docker image. ▶Source code for nano-lazar publication (and oral presentations). https://github.com/enanomapper/nano-lazar-paper ▶Manuscript submitted to Frontiers in Pharmacology https://github.com/ enanomapper/nano-lazar-paper/blob/master/nano-lazar.pdf ▶Tutorial for repeating nano-lazar validation experiments https: //github.com/enanomapper/nano-lazar-paper/blob/master/README.md ▶Docker image for inspection and reproduction of validation experiments https://hub.docker.com/r/insilicotox/nano-lazar-paper/ lazar-rest lazar-rest provides an eNanoMapper compatible REST API for the nano-lazar read-across framework. ▶lazar-rest Swagger UI documentation for API visualization and interaction [5] https://enm.in-silico.ch ▶lazar-rest Swagger API deﬁnition ﬁle https://enm.in-silico.ch/api/api.json ▶lazar-rest source code https://github.com/opentox/lazar-rest ▶lazar-rest Ruby gem library https://rubygems.org/gems/lazar-rest ▶lazar-rest issue tracker https://github.com/opentox/lazar-rest/issues ▶lazar-rest API documentation http://www.rubydoc.info/gems/lazar-rest SPARQL endpoint for eNM ontology and data SPARQL query interface for eNanoMapper data and ontologies ▶SPARQL endpoint https://sparql.enanomapper.net/ ▶Documentation http://enanomapper.net/deliverables/d3/20160420_ eNanoMapper_D3.2_Data_Management_System_with_extended_search_ capabilities_FINAL.pdf ▶Docker image https://hub.docker.com/r/insilicotox/ist-enm-virtuoso/ eNM ontology viewer The eNanoMapper ontology viewer visualizes SPARQL query results from eNM ontologies and data. ▶eNanoMapper ontology viewer [6] https://query.enanomapper.net/ ▶eNanoMapper ontology viewer source code https://github.com/enanomapper/enm-ontoviewer ▶eNanoMapper ontology viewer issue tracker https://github.co	poster
SEARCHING FOR A SECOND OCCULTATION IN EPIC 204376071 Roi Alonso1,2, Hans J. Deeg1,2, Saul Rappaport3 1 Instituto de Astrofísica de Canarias, Spain 2 Dpto. de Astrofísica, U. La Laguna, Spain 3 Department of Physics, and Kavli Institute for Astrophysics and Space Research, M.I.T., USA EPIC 204376071 is a young (~10 Myr) M star (estimated mass ~0.16 M☉, and radius 0.63 R☉), probable member of the Upper Sco association, that exhibited an 80% drop in flux lasting one day, in the course of one campaign of the K2 mission (Rappaport et al. 2019). Different scenarios have been proposed to explain this feature, some of them requiring a periodic behaviour of these events. With only one event observed, it becomes challenging to obtain further observations to investigate further the origin of the abrupt flux drops, and start confirming/rejecting possible scenarios. We have obtained new photometric observations, and analysed archival photometry, with the goal to identify additional flux drops on this star, and get the ephemeris, should these events be periodic. New data : LCOGT 0.4 m telescopes: located at Teide, Hawaii, Australia, South Africa, Chile, Texas. Semesters 2019B, 2020AB, 2021AB, 2022A Archival data: K2, ATLAS Fig. 1: The light curve of EPIC 204376071 for three analysed data sets: K2 in blue, ATLAS in green, and our LCOGT observing runs in orange. No additional deep events were detected. Fig. 2: The detectability window for different assumed periods of the events, from 70 to 1200 days, constructed from the time vector of the observations. We have significantly improved the coverage of periods in this range, and excluded all potential periods below ~120 days. BLUE: using only K2 data. ORANGE: Adding our LCOGT observations We did not detect any convincing additional event in our observations. Assuming a periodic nature of the events, these observations exclude possible periods of deep flux drops. With only K2 data, ~80% of the periods between 70 and 1200 days would have been missed. With the new data, this fraction drops to ~40%. If the occultation event observed by K2 is periodic, it is thus of a relatively long period. This object is not observed nor planned to be observed by TESS (Years 1-6), and thus ground- based observations with LCOGT and ATLAS as the ones presented here constitute our best chances to detect additional occultation events on this fascinating object. Rappaport et al. 2019, “Deep long asymmetric occultation in EPIC 204376071” MNRAS, 2019, 485, 2681R Read more about EPIC 204376061:	poster
Qualification of OLCI products from S3 for turbid lakes: results from the Lake Trasimeno M. Bresciani1, C. Giardino1, A. Hommersom2, G. Luciani1, V. Della Bella3, A. Cingolani3 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement n° 730066 Co-funded by the European Union Lake Trasimeno is a turbid, meso-eutrophic, unstratified shallow lake (average depth 4.5 m, max depth 6 m) with a size of 124 km2. It has three small islands and an open bay colonised by aquatic vegetation with exceptional value for biodiversity. Tourism, agriculture and livestock breeding are the most important activities in its area. 3. Materials and methods The WISPStation is a fixed position spectrometer system for measuring Rrs from 350 to 900 nm at 3 nm resolution. The Trasimeno WISPStation (nearby Polvese island) it has been running from 24 April to 3 October 2018, collecting Rrs spectra every 15 min. By using appropriate bio-optical models and algorithms, this system provides data on the intra and inter daily variability on concentrations of water quality parameters 2. Study area 1. Aims Remote sensing reflectance (Rrs, in sr-1) of Lake Trasimeno waters for different yet typical conditions during the season; the peak near 700 nm is always present from mid-July until the end of September; diatoms in spring and cyanobacteria in summer- autumn. The waters are belonging to Optical Water Type (OWT) classes #8 and #12. Concentrations of Chl-a and TSM measured from corresponding water samples are given as reference The aim of this work is to evaluate Sentinel-3 OLCI in lake waters to map chlorophyll-a concentrations (Chl-a) and to provide spatial and temporal information on phytoplankton dynamics to support the EU Water Framework Directive (EC/2000/60). The panel below show Rrs spectra as derived from WISPStation and from Sentinel 3, both OLCI-L2 and Level 1, the latter corrected with 6S, Polymer and C2RCC. Overall all processors are close to WISPStation data; a larger deviation is given by C2RCC and OLCI-L2 when the peak around 700 nm is appearing due to the growth of phytoplankton. Based on the best match, 6S and Polymer were finally adeptly selected to process all 2018 images. Sentinel 3A and 3B OLCI L1 images acquired in 2018 were converted into Rrs with three atmospheric correction codes: 6S vector version (6S), Polymer and C2RCC. Sentinel 3A and 3B OLCI L2 EUMETSAT images (OLCI-L2) were also included in this study. The OLCI-derived spectra were evaluated thanks to the comparison with continuous in situ hyperspectral Rrs data acquired by a WISPStation. The OLCI-derived Rrs products were then converted into Chl-a maps with the bio- optical model, implemented in BOMBER, parametrized with optical properties of Lake Trasimeno. 4. Results Fitting of Rrs between OLCI products and WISPStation data (± 15min), in terms of r Person correlation coefficient and relative root mean square error Chl-a maps of 2018; the products were provided to the regional water authority (ARPA Umbria) responsible for supporting Lake Trasimeno management and the WFD reporting 5. Conclusions • OLCI is confirmed to be the prime satellite radiometer for observing water quality in lakes. • It provides accurate, timely and frequent information to support EU directives. • This study is supporting the contents of a White Paper on ‘Satellite-based Earth observation water quality monitoring, reporting and management for the Water Framework Directive’ (to be published by the end of May). Chl-a (mg/m3) 0 4,4 8 14,6 26,7 50 m winter spring spring- summer transition summer summer- autumn transition autumn WFD classes – Chl-a (mg/m3) average The panel below show some examples of OLCI-derived Chl-a products for the needs of the water authority responsible for WFD reporting. Aggregation based on WFD periods and classes Time series of Chl-a obtained from WISPStation, OLCI and in situ water sampling for Polvese island station W	poster
Coopera've Community Opportuni'es and the ADS Donna Thompson and Carolyn Grant ADS/Smithsonian Astrophysical Observatory The ADS is used daily by the astronomy community and beneﬁts from the coopera've nature of our contributors. In this poster we will outline some of the ways that the library community can con'nue to contribute to this resource. While most of what we receive is veCed before it gets to us, we some'mes ﬁnd ourselves in the posi'on of having to determine whether or not an ar'cle, proceeding or other submission is refereed. ADS has guidelines on how we determine this but some'mes the lines are not so clear. . . and some'mes the arguments on both sides are compelling. The process that we follow will be outlined and we would appreciate feedback on this topic. As online publishing trends con'nues to evolve, conference proceedings and presenta'ons, PhD theses and other digital ar'facts are being deposited to research data repositories such as Zenodo or Dataverse. We will describe the process that ADS follows to include relevant collec'ons from such repositories when properly curated by librarians or researchers. This paper is refereed. This should be in ADS. You can contribute to the ADS! Send your ques'ons and contribu'ons to ads@cfa.harvard.edu. We look forward to hearing from you! Occasionally we receive an email from a user sta'ng that his/her paper is refereed and why isn’t it that way in ADS? ADS considers ar'cles refereed when they appear in journals that par'cipate in peer review. ADS does not consider materials that are veriﬁed only by an editor as refereed. We consult the website of the journal, conference or publisher and check industry trade standards. ADS seeks comprehensive, but not all- inclusive, coverage of the ﬁeld of astronomy. We receive regular feeds from publishers and Crossref and seek out conferences on the web. If you are aware of a conference or journal that is not included in the ADS, please let us know. We are par'cularly interested in non-US PhD theses. We download records from a select list of Zenodo collec'ons on a weekly basis and welcome your sugges'ons for communi'es and topics to add to the content harvested by ADS. I maintain a bibliography for my Ins'tu'on. ADS is used by many librarians to curate their ins'tu'onal bibliographies. The API available through ADS beta can help to streamline the process (see poster “Managing Ins'tu'onal Bibliographies using the ADS API: A new workﬂow using Google Sheets” for an example.) ADS can incorporate your curated bibliography into our holdings and add a ﬁlter for your ins'tu'on. This will make it easier for ADS users to correctly iden'fy researchers at each ins'tu'on. ADS has partnered with ORCID to allow one to claim papers and associate the papers with an author’s ORCID. (ADS is planning to integrate ORCID mappings curated by librarians into its database to complement data provided by publishers and claimed by users. A trial using data from the Harvard-Smithsonian Center for Astrophysics is planned for later this year.)	poster
Elements: Morpho-Cyberinfrastructure for scientists and engineers studying shape change Chaitanya Joshi, Daniel Goldstein, Anca Andrei, James Adler and Timothy J. Atherton PIs: Timothy J. Atherton, James Adler Award Number: 2003820 • The first ever Morpho workshop with participants from 5 different institutions took place on July 11th-12th 2022. • Participants were trained in the basic features of the Morpho language, as well as some advanced post- processing and graphics abilities. • Participants learnt how to set up shape and field minimization problems in Morpho from their own scientific domain, thus setting up multiple collaborative efforts and increasing the user-base of Morpho. 5. Morpho workshop • Morpho aims to solve problems in this general form: Minimize arbitrary functionals defined on a manifold C subject to global (integral) constraints, and local constraints , with respect to a set of field quantities q defined on it and the shape of the manifold. • Morpho uses auxiliary functionals to regularize under- constrained problems Modeling swelling hydrogels under confinement using tetrahedral meshes and level-set constraints. The red colored outline shows the swelling in the absence of confinement whereas the black lines show the mesh boundary expanding in the proximity of a stationary impenetrable plane and a superellipsoid. Confinements / obstacles are shown in light gray. 3A. Example: Swelling hydrogels Liquid crystal tactoids in 3D under various conditions. For 𝜅≪1, the surface tension holds the droplet in a spherical shape; as 𝜅≥1, the droplet elongates to form a spindle shape. The director field also undergoes a transition: for small 𝜔, elasticity overcomes anchoring leading to a homogenous directory field; for a large 𝜔, the director aligns with the surface producing a bipolar configuration. 3B. Example: Liquid crystal tactoids 1. Introduction Minimizing surface area for a fixed volume. The unregularized solution not only takes longer, but also converges to the incorrect solution. Taking advantage of the degeneracy of the solution, we regularize the elements, making the solution both fast and accurate. 2. The Morpho Language • Complete programming language, with a Python-like syntax. • Extensible: Users can write their own modules in the Morpho language. • Fully open-source, extensively unit-tested. • A Slack community provides a supportive and a collaborative environment. 4. Improvements • Continuous Integration with over 500 unit-tests. • New mesh generation suite. • Support for VTK I/O. • Support for M1 Macs • Prototypical GPU acceleration • New optimization algorithm based on Sequential Quadratic Programming coming soon. 6. Use by independent researchers 𝜅~ Elasticity 𝜔~ Anchoring Tom Powers and Bob Pelcovits’ group from Brown University to use Morpho to model colloidal membranes. (A) A saddle-shaped colloidal membrane formed from filamentous viruses. Scale bar, 2 μm. Adapted from Khanra et al. 2022 (arXiv: 2203.07133). (B) Modeling a colloidal membrane on an Enneper minimal surface in Morpho.	poster
PRELIMINARY STUDY ON THE EFFECT OF LED LIGHT AND CYTOKININE ON THE GROWTH OF PEAR PLANTS IN VITRO Nataliya Dimitrova1, Lilyana Nacheva1, Yulia Kyoseva2, Małgorzata Berova2 1 - Fruit Growing Institute, 12 Ostromila Str., 4004 Plovdiv, BULGARIA 2 - Agricultural University, 12 Mendeleev Str., 4000 Plovdiv, BULGARIA Corresponding author: natali.dimitrova@yahoo.com Material and Methods Plant material and experimental conditions The experiment was carried out on pear rootstock (Pyrus communis L. ‘Old Home’ x ‘Farmingdale’ 333). Briefly, shoots were grown in microboxes with green filter (SacO2, Belgium) on a modified MS (Murashige and Skoog, 1962) solid medium with ½ concentration of NH4NO3 and CaCl2 and 1000 mg L-1 Ca(NO3)2, supplemented with 2.5 µM 6-benzylaminopurine (BAP), 0.05 μM IBA, 30 g L-1 sucrose, 6.5 g L-1 Phyto agar (Duchefa, The Netherlands). The cultures were incubated in the growth room at an air temperature of 22±2C with 16/8 h hours photoperiod supplied by cool-white fluorescent lamps (OSRAM 40W; 50 µmol m-2s-1 PPFD). For the purpose of the present experiment the plantlets were cultivated in vitro on above mentioned basal nutrient medium, supplemented with 2.5 µM 6-benzylaminopurine (BAP) or 2.5 µM meta-Topolin (mT) at 22±2°C using an illumination system based on Philips GreenPower LED research module (16-h photoperiod with 80-95 µmol m-2 s-1 PPFD). Three groups of LEDs emitting in white (W), blue (B), mixed (BR) (W:B:red:far-red = 1:1:1:1) lights) were applied. Data on fresh (FW) and dry (DW) mass, number and length of shoots, the length and width of the first fully developed leaf, content of photosynthetic pigments was evaluated in six passages of three weeks of culture on the corresponding light regime. For each light treatment three replications, each containing ten shoots was tested and the experiment was repeated three times. Statistical analysis of physiological parameters was performed using a one-way ANOVA using the Tukey test to validate the different significance at P ≤0.05. Fig. 2. Gas-exchange filters of the polypropylene containers allows air flow, but blocks contamination. Fig. 3. The size of the first fully developed leaf of pear plantlets, grown with BAP or mT in the nutrient medium at different light treatments. W white LEDs, B – blue LEDs, BR – mixed LEDs. Results Fig. 1. The appearance of pear plantlets, grown with BAP or mT in the nutrient medium at different light treatments.W white LEDs, B – blue LEDs, BR – mixed LEDs. Table 1. Growth indices measured in pear plantlets grown with BAP or mT in the nutrient medium at different light treatments. W white LEDs, B – blue LEDs, BR – mixed LEDs. For each column, different letters indicate significant differences at p≤0.05. LED Light Cytokinin Length of Shoot /mm/ Number of Shoots Number of Leaves FW /g/ DW /g/ White BAP mT 20.76 a 15.96 b 1.2 a 1.0 a 7.3 ab 9.2 ab 1.20 a 1.55 a 0.34 ab 0.47 a BR BAP mT 11.98 c 20.58 a 1.6 a 1.0 a 10.4 a 7.5 ab 0.67 a 0.98 a 0.15 b 0.18 b Blue BAP mT 21.96 a 15.90 b 1.6 a 1.1 a 9.1 ab 5.7 b 1.17 a 1.28 a 0.29 ab 0.34 ab Table 2. The content of photosynthetic pigments (mg g-1 FW) in the pear plantlets cultivated with BAP or mT in the nutrient medium at different light treatments. W white LEDs, B – blue LEDs, BR – mixed LEDs. For each column, different letters indicate significant differences at p≤0.05. LED Light Cytokinin Chl a Chl b Chl (a+b) Car Chl a/b Chl(a+b)/Car White BAP mT 0.52 a 0.26 cd 0.17 a 0.09 bc 0.69 a 0.35 c 0.23 a 0.14 b 3.05 ab 2.96 b 2.95 b 2.58 c BR BAP mT 0.25 cd 0.21 d 0.09 bc 0.08 c 0.34 c 0.30 c 0.15 b 0.11 b 2.58 c 2.61 c 2.31 d 2.74 bc Blue BAP mT 0.39 b 0.32 bc 0.12 b 0.10 bc 0.51 b 0.42 bc 0.16 b 0.16 b 3.15 ab 3.29 a 3.26 a 2.63 b Fig. 4. Effect of the light and cytokinin on the net photosynthetic rate (μmol CO2 m-2 s-1) and transpiration intensity (E, mmol H2O m-2 s-1) of pear plantlets; Different letters within column indicated difference at (Р<0.05). Conclusions Plantlets grown on the nu	poster
DR Analysis How variation in Cochlear Implant performance relates to differences in MAP parameters Enrico Migliorini12, Bas van Dijk1, Birgit Philips1, Emmanuel Mylanus2, Wendy Huinck2 1) Cochlear CTCB, Mechelen, Belgium 2) Radboud university medical center, Nijmegen, The Netherlands In this project we investigated T (threshold) and C (comfort) levels of 298 CI recipients at the Radboud university medical center. The recipients were all postlingually deaf adults, and all tests were NVA CVC tests in quiet, at a presentation level of 65 dB SPL. The first step performed was conducting Principal Component Analysis to turn the 44-dimensional dataset to a 4-dimensional one. Figure 1: Explanations of the four PCA components. Figure 1a correlates strongly with the average T- and C-level, 1b with Electrical Dynamic Range (EDR), 1c with tilt and 1d with curvature. Figure 2: Distributions of the PCA parameters in the two populations We then separated the top and bottom tertiles of performance from the population: the former containing 100 recipients scoring higher than 69% estimated Word Score, and the latter containing 101 recipients scoring lower than 45%. The only component for which a Mann-Whitney-Wilcoxon test showed a significant difference between the populations is the second one (p=0.001, see Figure 2b). From Figure 1b we can see that this component mainly described the Electrical Dynamic Range (C-T level). The next step was to repeat the analysis on the same populations, this time precisely defining the aggregate values we were considering: T-levels, C-levels, EDR, and the tilt of T- and C-levels. The Mann-Whitney-Wilcoxon test confirmed the significant difference in EDR between the two populations (Top and bottom tertile). Figure 3: Distributions of dynamic range in the two populations An association between EDR and Speech Audiometry scores has been shown before by both Kim1 and de Graaff2. Further investigation may shed light on the causal relation between the two values: does better DR help some recipients, or are higher- scoring recipients able to make use of a wider DR? 1. Kim SY, Jeon SK, Oh SH, Lee JH, Suh MW, Lee SY, Lim HJ, Park MK. Electrical dynamic range is only weakly associated with auditory performance and speech recognition in long-term users of cochlear implants. Int J Pediatr Otorhinolaryngol. 2018 Aug;111:170-173 2. de Graaff F, Lissenberg-Witte BI, Kaandorp MW, Merkus P, Goverts ST, Kramer SE, Smits C. Relationship Between Speech Recognition in Quiet and Noise and Fitting Parameters, Impedances and ECAP Thresholds in Adult Cochlear Implant Users. Ear Hear. 2020 Jul/Aug;41(4):935-947 Figure 4: Average MAPs for the two populations Figure 5: Dynamic range correlation with scores An analysis of the histogram and its Kernel Density Estimation curve appears to suggest that the top tertile population may be composed of two subgroups: one group showing a dynamic range of approx. 40 to 50 Current Levels (CL) and one showing a dynamic range of approx. 60 to 80 CL. There is also the possibility of confounders, such as neural health or native language, which may influence both DR and speech understanding. This possibility must not be ignored. Conclusions PCA Analysis Higher speech audiometry scores appear associated with wider Dynamic Range 1a 1b 1c 1d 2a 2b 2c 2d Additional research question: Does increased Dynamic Range improve the speech understanding of some CI recipients?	poster
Assessment of genetic diversity of white lupin (Lupinus albus L.) accessions based on agro-morphological traits Sofia Petrova Institute of Plant Genetic Resources “Konstantin Malkov”- Sadovo corresponding author: soniapetrova123@abv.bg Introduction Lupinus is a relatively large genus and one of the most geographically widespread with a rich diversity of species. Lupin is an annual or perennial legume belonging to legume family, Fabaceae, one of the oldest crops. In our country lupin is not a traditional crop, but it has been used for a long time as a green manure source. The conservation and preservation of the white lupin genetic resources are of crucial importance for the breeding programs aiming the cultivar improvement. The aim of this study was to assess the genetic diversity of ten white lupin accessions regarding components of productivity and biological traits. Material and Methods Ten white lupin genotypes were used for this study. At maturity was measured following morphological traits: plant height, height to the first pod, number of productive branches, number of pods per plant, number of grains per plant, number of grains per pod, mass of grains per plant and mass of 100 grains. The phenological traits were assessment by coefficient of earliness. For ultra early varieties the value of this coefficient was from 1.00 to 1.17, for the early varieties from 1.17 to 1.33, for middle-early ones from 1.34 to 1.66 and for the late varieties was greater than 1.66. The studied agro-morphological traits were processed mathematically by analysis of variance. To investigate the genetic diversity between the studied lupin accessions was used Cluster analysis. Results and discusion The clustering of the lupin accessions based on their morphological traits is presenting on Fig. 1. The traits data are given on Table 1. The accessions were divided into two main groups (clusters). Only the accession BGR3080 was included in the first cluster. This genotype had large grains, big mass of grains per plant and big number of grains per pod. The second claster was divided into two sub-clusters. The first sub-cluster included three genotypes, with tall plants, big number of productive branches and big mass of grains per plant. The BGR 3086 genotype differed significantly by plant height. This accession also had a high number of grains per plant and the shortest vegetation period. The accession BGR6341 had significant differences by plant height, number of productive branches, number of grains per plant and mass of grains per plant. This accession characterized also by high values of number of pods per plant and number of grains per pod. The BGR 3085 accession had significant differences by mass of grains per plant. The second sub-cluster included six accessions possessing medium-high to short stem and medium-large to large grains. The data showed that within this sub-cluster significant genetic distance was observed between the genotypes. The clustering of the agro-morphological traits of the lupin accessions is presented on Fig. 2. From the clustering of the traits we could concluded that they were combined into two main clusters. Only vegitation period was included in the first cluster. The second cluster was divided into two sub-clusters: the first sub-cluster included the following traits: plant height, number of grains per plant, germination-beginning of flowering, mass of 100 grains and height to the first pod united by the close value of the Euclidean distance. The remaining four were combined into the second sub-cluster. Accession Plant height, сm Height to the first pod, cm Number of productiv branches Number of pods per plant Number of grains per plant Number of grains per pod Mass of grains per plant, g 100 grains mass, g BGR 3083 53.29 28.00 2.14* 8.71 35.00 4.49 13.23 37.80 BGR 6339 51.57* 23.43* 3.14 10.14 40.29 4.77 14.84 37.05 BGR 6337 55.43 22.57** 3.57 11.57 45.43 4.80 14.43 32.45 BGR 3080 63.86 28.14 3.14 12.14 47.43 4.90	poster
C • Neutrino detector located 2 km underground at SNOLAB, in Canada • Acrylic vessel filled with 780 tonnes of liquid scintillator • Ionising radiation generates scintillation light • The light is recorded by the 9362 PMTs • The muon rate is ~3 per hour Physics goals include the search for neutrinoless double beta decay from tellurium-130 and measurements of the reactor, solar, supernovae and, geo neutrinos CC on Carbon-13 𝑒! Prompt Event Delayed Event • Data-driven background rates • The fiducial volume, ΔR, ΔT and delayed energy window were jointly optimised • The annihilation produces two gammas which are detected • A positron with energy: [1.0 to 2.2] MeV • Imposing a 5 MeV cut removes most background, for example, the Thallium-208 decay (Q = 5 MeV) 𝟖𝑩 𝟖𝑩𝒆+ 𝒗𝒆+ 𝒆# Likelihood Analysis 𝑣! &'𝐶 &'𝑁 𝑣! &'𝐶 𝑒( 𝑒! 𝛾 𝛾 𝑡$ % ≈10 𝑚𝑖𝑛 Using PDFs of the delayed energy (1 to 2.2 MeV), ΔT (0.01 to 60 min), and ΔR (<1 m), the Likelihood ratio can be constructed A predetermined cut that maximise significance gives an expected background number of 0.17 and a signal of 1.79 Two events observed, giving a background fluctuation probability of 1% The successfully validated background model gives confidence in the extrapolation of sensitivity Cuts-Based Analysis • The remaining prompt background is 8B Elastic scattering These cuts give an expected background number of 0.31 and a signal of 1.83 Two events observed • Electron with energy = 𝐸(𝜈!) −2.2 𝑀𝑒𝑉 [2] T. Suzuki, A. B. Balantekin, and T. Kajino, Neutrino capture on 13C Phys. Rev. C 86, 015502, 2012 Analysis is being continued on an expanded data set Backgrounds [1] Borexino Collaboration, M. Agostini et al., Comprehensive measurement of pp-chain solar neutrinos, Nature 562, 2018 Gulliver Milton on behalf of the SNO+ collaboration SNO+ experiment Φ "# = 5.20 $%.' (%.' × 10) 𝑐𝑚$*𝑠$' [1] FV < 5.3 m ΔR < 0.36 m 0.01 < ΔT (min) < 24 1.14 < 𝐸!! (MeV) < 2.2 [3] P. A. Zyla et al, (Particle Data Group), Review of Particle Physics, Prog. Theor, Exp. Phys, 083C01, 2020 Livetime: 170 days (pre-cuts), 150 days (post-cuts) • This is obtained by integrating over the theoretical cross- section [2] and SSM 8B neutrino flux [1], assuming the globally fit neutrino oscillations parameters [3] • The dominant background is from accidental coincidences Predetermined cuts First Indications of CC Solar Neutrino Interactions on Carbon-13 Signal • The fraction of events resulting in fake coincidences allows the random coincidence rate to be determined • The cross-section of the interaction is orders of magnitude larger than the electron ES process [2] • In SNO+ there are expected 22 ev/yr/kT 8B neutrino CC interactions with 13C • Given the low muon flux at SNO+, modest muon followers cuts reduce the cosmogenic background (11Be prompt + 11C delayed) to a negligible 7.0×10-4 ev/yr/kT • Spurious prompt events were used to produce “fake coincidences” with data events satisfying delayed event cuts • The 1.1% natural abundance of 13C in the organic scintillator can undergo a charged current interaction with neutrinos • The CC reaction on 13C has a threshold of 2.2 MeV and produces a 13N, which then decays • The coincidence nature of the event significantly reduces the background • Solar neutrinos produced in 8B decays from the pp chain in the Sun arrive at Earth with a flux of:	poster
The effects of disinfection on Clavibacter michigansensis subsp. sepedonicus and other bacterial pathogens of potato in Europe Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 353,000 Picture 1 Picture 1 Picture 1 Goals The project aims to investigate the efficacy of disinfectants on Clavibacter michiganensis subsp. sepedonicus (ringrot) and other bacterial pathogens of potato and their optimal application techniques. The main focus will be on disinfection of materials (in particular wooden boxes used for potato storage). Research consortium NL-EL&I, LT-MoA, UK-SASA Contact information Project coordinator: Leon Tjou-Tam-Sin n.n.a.tjou-tam-sin@nvwa.nl Key outputs and results • A Report describing the experiments and results in which efficacy of disinfectants is tested • A disinfection protocol to effectively disinfect materials (in particular wooden boxes used for potato storage) Objectives • Assessment of the efficacy of selected disinfection methods and disinfectants • Selection of a suitable methodology to effectively disinfect materials (in particular wooden boxes) 04/2013-12/2015	poster
Fast and Powerful Multiple Testing Inference in Family- Based Heritability Studies Habib Ganjgahi1, Anderson Winkler2, Peter Kochunov3, David C. Glahn4 ,John Blangero5, Thomas E. Nichols1. 1Department of Statistics, University of Warwick, Coventry, UK; 2 FMRIB, University of Oxford, UK; 3Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; 4Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA 5AT&T Genomics Computing Center, Texas Biomedical Research Institute., Texas, United States. Introduction Estimation of heritability is essential in imaging genetic studies. Voxel-wise heritability for traits like cortical thickness, fractional anisotropy and BOLD activations have been made practical by genetic analysis tools optimized for imaging research, such as the SOLAR/SOLAReclipse (Kochunov2013). The mass-univariate nature of voxel-wise analyses, however, presents a severe multiple testing problem. In this work we present a fast and powerful permutation test for general pedigree studies that provide traditional, spatial inferences for images, including familywise error corrected voxel- and cluster- level inference. Methods Voxel-wise Heritability Estimation: Heritability estimation is performed using variance component models. In this approach, the phenotype covariance matrix is decomposed into two components, one for the additive genetic effect and one for the combination of individual-specific environmental effects and measurement error Σ = 2𝜎𝐴 2Φ + 𝜎𝐸 2𝐼. The parameters are estimated by maximizing the likelihood function under a multivariate normal assumption. An orthogonal transformation (based on the eigenvectors of the kinship matrix) is used to accelerate computation. Hypothesis testing is performed with a likelihood ratio test (LRT). Permutation Procedures We propose two permutation tests for heritability inference. The first method is based on the permuting the rows and columns of the kinship covariance matrix, and repeatedly fitting the model and computing the LRT; this provides uncorrected p-values at each voxel and, via the maximum LRT (or maximum cluster-size, based on thresholded LRT images) FWE-corrected p-values. Note that this method requires the iterative optimization of the likelihood function for each permutation, which is computationally intensive. The second method is based on constructing an auxiliary regression model on squared residuals and the kinship covariance matrix eigenvalues. After orthogonal transformation of the data, the second moment of residuals has a linear relationship with the additive genetic effect and the kinship matrix eigenvalues: 𝐸𝑒𝑖 2 = ℎ2 𝜆𝑔𝑖−1 + 1, where 𝑒 and 𝜆𝑔are transformed residuals and the kinship matrix eigenvalues respectively (w.l.o.g. we assume data is scaled to unit variance). Based on this expression we fit a regression model, where there is only one unknown parameter (ℎ2), and the usual regression sum of squares provides a test- statistic. Simulation Monte Carlo simulation was used to validate the permutation tests cluster size inference for multiple testing error correction in imaging heritability studies. We simulated smooth images of size 64 by 64 containing a circular region of true heritability for two pedigrees, of total 138 subjects. Heritability was varied, ℎ2 = {0, 0.2, 0.4, 0.6}. 500 permutations were used, and the entire simulation was repeated with 1000 realized datasets. Results See figures. Conclusions We have developed permutation-based heritability methods for general family data, providing spatial inferences that are useful for brain-imaging. Cluster wise inference based on constructing the auxiliary regression model provides exact control over FWE and has power comparable with LRT. References Blangero et al (2013). A kernel of truth: statistical advances in polygenic variance component models for complex human pedi	poster
On this captivating journey of question-solving and coding challenges, you will test your knowledge on microplastics, discover the research carried out in Imptox and help NanoNinja catch PlastikPunk and free the world from plastic trash. Don’t hesitate and sign up for the advenuture! A VIDEO GAME TO DISCOVER THE HIDDEN WORLD OF MICROPLASTICS Imptox has received funding from the EUs H2020 framework programme for research and innovation under grant agreement n. 965173. This project is part of CUSP, the European research cluster to understand the health impacts of micro- and nanoplastics (MNPs). MICROPLASTIC M A D N E S S CATCHING PLASTIKPUNK PLAY NOW	poster
P128 An Approach to Control Purity of the Drug Substance for Non-Clinical Study T. HASHIMOTO1, Y. KOBAYASHI1, Y. OKUBO1 1 Res. Lab., Toyama Chemical Co., Ltd., Toyama, JAPAN Synthetic Route of API (Compound 12) Corresponding author: Yusuke Okubo, Mailing address: Research Laboratories, TOYAMA CHEMICAL CO., LTD. 2-4-1 Shimookui Toyama 930-8508, JAPAN, E-mail: YUSUKE_OKUBO@toyama-chemical.co.jp Tel: +81 (0)76-431-8267 Fax: +81 (0)76-431-8208 Background: Purity of drug substance (API) used for clinical study must be the same or higher than that of API used for non-clinical study (NCAPI). It is important to allow flexibility in developing manufacturing process to design and control the purity of NCAPI. There are various ways to optimize the purity on purpose, such as addition of individual impurities on use of harsh chemical reactions. In the present study, we established a method to ensure the desired purity of NCAPI by adding a separate set of API containing various species of impurities (IMAPI). Methods: Firstly, the target purity of NCAPI was determined by the purity of API used for a two-week repeated dose toxicity study in the dog. Secondly, IMAPI was prepared in lab, and lab experiments were conducted to determine how much IMAPI needed to achieve the target purity of NCAPI at large-scale manufacturing. Thirdly, we conducted large- scale manufacturing by addition of IMAPI and confirmed whether the purity of NCAPI was within the desired one. Results: The purity of API used in the dog toxicity study was 97.8%, so we set the target purity at 98%. IMAPI was synthesized with the purity of 82.2%, and added to the reaction mixture in large-scale production. Crystallization and filtration gave 37.4 kg of NCAPI with the purity of 99%, which is slightly higher than the target purity. Conclusions: These results indicate that this method is useful for purity design of NCAPI. Abstract Introduction Methods 1. Target purity and impurity profile determination API for a two-week repeated dose toxicity study in the dog was synthesized. Target purity and impurity profile of NCAPI were determined. 2. Preparation of IMAPI IMAPI was prepared by adding the residue of the filtrates, process intermediates, and degradate, which were prepared separately. 3. IMAPI spike tests Reaction mixture in the final manufacturing step was spiked IMAPI to determine where the appropriate process to add and how much IMAPI needed to optimize the purity and the target impurity profile of NCAPI at large-scale manufacturing. 4. Manufacturing NCAPI NCAPI was manufactured by adding IMAPI to the reaction process of the final manufacturing step. Result 2: Preparation of IMAPI Result 1: Synthesis of the API for a two-week repeated dose toxicity study in the dog Summary of results 1. The purity of API used in the dog toxicity study was 97.8%. Therefore, the target purity of NCAPI was set at 98%. Major impurities in this API were identified to determine the target impurity profile. 2. IMAPI was synthesized with the purity of 82.2% and major impurities were included. 3. Spike tests showed that adding 1.0 wt% IMAPI to the reaction process produced API with the purity of 98.0%, achieving the target purity profile. Adding IMAPI to the crystallization process did not affect the purity of the API. 4. NCAPI was manufactured by IMAPI. Adding IMAPI to the reaction process afforded 37.4 kg of NCAPI with the purity of 99.0%, which is slightly higher than the target purity. Impurities presented in NCAPI were as we anticipated. Conclusion Alkylation Reaction 75% yield Pd-Coupling Reaction 90% yield Ring-Closing Reaction Reaction with Hydroxylamine 80% yield 95% yield Coupling Reaction 90% yield APIs intermediates filtrates byproducts degradates + = IMAPI Result 3: Spike tests of IMAPI Result 4: Manufacturing NCAPI Ring-Closing Reaction Work-up Crystallization Filtration Compd. 11 Crude Compd. 12 Filtrate Dissolution Crystallization Filtration and Wash Filtrate Compd. 12 450 g (two lots)	poster
www.coastalwarming.com/cctbon www.instagram.com/ruiseabra twitter.com/fpslima MONITORING TEMPERATURE IN HARSH ENVIRONMENTS Whether on temperate, tropical, or polar coastlines, recording temperatures every hour for very long periods of time and with minimal maintenance requires unique tools and methodologies. We used our decade-long experience in the monitoring of intertidal temperatures to develop the EnvLogger T7.3 temperature logger (size: 27x11mm; www.electricblue.eu/envolggers). The T7.3 can collect up to 15 years of hourly temperature readings without the need for any maintenance, opening up the possibility of monitoring even the remotest locations. The device is also fully encased in resin, making it extremely rugged and safe for the environment. 10.1126/science.adl6580 The tiny temperature loggers are deployed snugly inside shallow holes drilled on the rock using a 30mm drill bit (just 3mm wider than the loggers). Loggers are then glued using a two-part epoxy (Splash Zone A-788) that hardens even underwater, creating a very tight and long-lasting bond. Sitting ﬂush with the rock’s surface and protected from nearly all sides, they can withstand even the harshest wave impacts and still be accessible for downloading the recorded data. Out of the more than one thousand loggers we have already deployed, the recorded yearly failure rate remains under 0.1%, and we’ve never encountered a leaking battery. Still, if a logger must be removed or replaced, a hammer and a chisel can be used to chip away the epoxy shell and safely pry out the electronics without compromising the integrity of the battery. We always collect all components and pieces of resin. If monitoring is being discontinued, we also smooth out the holes. Even just one year after deployment, loggers often become colonized by the local biodiversity, such as limpets, barnacles, algae, and others, rendering them very inconspicuous in the environment and ensuring that their aesthetic impact in the wilderness is negligible. Our team uses several strategies to document each logger’s positions so that they can be found later on. Recorded data is downloaded using iOS/Android smartphones equipped with NFC (Near Field Communication) by simply tapping the logger’s exposed surface. A total of 10 temperature loggers are deployed in each shore: 5 exposed to the sun and 5 in shaded rock faces. This allows us to characterise each shore’s thermal envelope - the highest and lowest temperatures available at any moment. Since the loggers are always deployed at the mid-shore level, some of the temperatures are recorded while the loggers are underwater, exactly as experienced by intertidal organisms. These data will allow the study of the impact of Global Warming on coastal biodiversity with unprecedented detail. #3 - data download #3 - data download #5 - data analysis #5 - data analysis 2 1 3 4 5 6 #1 - the device #1 - the device #2 - deployment #2 - deployment #4 - removal #4 - removal 10.1126/science.adl6580 R Seabra is a National Geographic Explorer Lindblad Expeditions - National Geographic Fund Hot loggers are deployed in rocks with maximum exposure to the sun Cold loggers are usually deployed in cracks or under overhangs C1 H5 + H4 H3 H2 H1 H4 H5 C2 C3 C4 C5 H2 H3 H1 C1 C2 C3 C4 C5	poster
KIT – The Research University in the Helmholtz Association h Introduction to the KATRIN Rear Wall (RW) e- Analyzing RW Systematic via Measuring the Rate and Spectrum from RW − Events Non- Mitigated RW Surface(s) How Can We Model the RW Contaminant? Gold RW Surface Conclusions and Further Studies: The spectral shape near the endpoint is analyzed to determine the neutrino mass signature. − Spectrum Endpoint Region KATRIN measures the energy spectrum of the - near the endpoint. Molecular Tritium Decay Products Gaseous tritium undergoes - decay. Molecular Tritium KArlsruhe TRItium Neutrino Experiment (KATRIN) Direct Measurement of the Neutrino Mass KNM1-5 Uncertainties m< 0.8 eV/c2 (90% C.L.) The Rear Wall (RW) Mitigated RW Surface Au Au During KATRIN operatations, electrons bombard the unknown CnHm, breaking the -bonds and the CnHm. Example hydrocarbon chain (CnHm) pre-existing on RW CnHm with -bond opened by electron bombardment Tritium bonds to the newly opened - bonds resulting in amorphous structure. Newly created tritiated amorphous hydrocarbon (aCnTm) on RW − from T decay of aCnTm have a different spectrum than − from source A Possible Origin for the RW Systematic Evolution of the RW rate Evolution of the RW spectrum & Nat. Phys. 18, 160- 166 (2022) ❖We divide our RW data into epochs between surface cleanings with UV and ozone. ❖Integral flow is the total tritium circulated through the source since a given time. RW rate measurements are performed whenever there is no tritium in the gaseous source (e.g., between KATRIN Neutrino Mass Campaign “KNM” etc). For these measurements, we count the rate above a fixed retarding energy threshold. From these measurements, we found the RW rate has a predictable growth during epochs. ❖ ❖ ❖ RW spectrum measurements are performed by varying the retarding energy threshold to scan the RW −spectrum and then fitting a model to that RW −spectrum. Our goal is to find a minimal set of parameters for the RW spectrum model. The RW spectrum parameters are signal, endpoint, and FSD shape. The FSD shape compares the Final State Distribution (FSD) of the RW substance to that of T2. ❖ ❖ ❖ ❖ The RW rate and signal have consistent behavior across epoch 1 and 2. In epoch 3, the RW signal and rate are lower and more stable than in epochs 1 and 2. The RW endpoint and FSD shape have -0.96 correlation coefficient. Further Studies: We plan to next determine the RW uncertainty for KATRIN datasets post KNM1-5. The RW tritium spectrum has a systematic effect on the neutrino mass which can be addressed by including the RW spectrum in neutrino mass fits. This systematic effect has been successfully mitigated. Conclusion: ❖ ❖ ❖ Tritium bonds to the open pi bonds in the CnHm creating aCnTm. UV and ozone cleaning removes the chemisorbed tritium and some of the aCnTm beneath (Fusion Science and Technology 80.3-4 (2024): 303-310.). The aCnTm has been almost removed. We see that there is limited accumulation of tritium activity (T adsorbs poorly on Au). Possible Model: A big, initial CnHm layer that later saturates with tritium. ❖ 1. 2. 3. T T e- e- T + + He Detector Main Spectrometer Gaseous Source Magnetic fields guide - from the source to the detector A bias voltage is applied to the RW to help to control the starting potential of electrons in the gaseous source. CnHm becomes tritiated aCnTm is cleaned from RW Initial CnHm layer on RW Au C H H H H C We acknowledge the support of Helmholtz Association (HGF), Ministry for Education and Research BMBF, the doctoral school KSETA at KIT, Helmholtz Initiative and Networking Fund, Max Planck Research Group, and DFG in Germany; Ministry of Education, Youth and Sport in the Czech Republic; INFN in Italy; the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation in Thailand; and the DOE Office of Science, Nuclear Physics in the United States. This project has received fu	poster
0 20 40 60 80 100 Open Closed Glasses Eyes Score of recognition (max: 100) * * 0 20 40 60 80 100 Open Closed Glasses Eyes Score of recognition (max: 100) Emotion Anger Fear Happiness Neutral 0 20 40 60 80 100 Open Closed Glasses Eyes Score of recognition (max: 100) Emotion Anger Fear Happiness Neutral 0 20 40 60 80 100 Open Closed Glasses Eyes Score of recognition (max: 100) Emotion Anger Fear Happiness Neutral 0 20 40 60 80 100 Open Closed Glasses Eyes Score of recognition (max: 100) Emotion Anger Fear Happiness Neutral * * * * * * *** *	poster
Global Grant IDs in Europe PMC Michael Parkin, Maria Levchenko, Jo McEntyre Europe PMC, EMBL-EBI European Bioinformatics Institute Summary Europe PMC, a database of life science research literature, incorporates the ﬁrst open, global grant IDs into its workﬂows. In a collaborative eﬀort between Crossref, Wellcome (one of the Europe PMC funders), and Europe PMC, the ﬁrst global grant IDs have been registered for Well- come grants. Wellcome recently joined Crossref through a new type of membership developed speciﬁcally for this purpose. Europe PMC regis- ters global grant IDs for Wellcome-funded awards with Crossref on behalf of the funding agency, and provides the necessary metadata based on the information in its grant database. The grant IDs resolve to the corresponding grant record on the Europe PMC website. The aim of this development is to make it easier to unambiguously and eﬀectively track the impact of research funding, ensure transparency of the funding in- formation and simplify linking to research outputs, such as research publications. Linking research objects The adoption of global grant IDs allows us to link publications and grants hosted in Europe PMC, supporting better tracking of the re- search funding impact and providing greater transparency for the funding information. In a pilot eﬀort, the journal PLOS ONE has coordinated with Well- come-funded authors to include newly registered global grant IDs in the metadata of the publication. As the grant ID links to the grant record on Europe PMC’s website, the readers can now readily exam- ine the support provided by Wellcome for this study. doi.org/10.35/1077 GRANT How to get involved We hope that global grant IDs will simplify researchers’ work- ﬂows, with grant data collected on submission by publishers and repositories and automatically fed into assessment platforms. If you would like to incorporate global grant IDs into your own workﬂows or retrieve grant metadata, get in touch via helpdesk@europepmc.org. Future plans The ﬁrst two Wellcome grant IDs have been registered as a proof-of-concept. Our next step is to launch an automated pipe- line to register IDs for Wellcome grants from 2019. Following is retrospective grant ID assignment for nearly 13,500 Wellcome grants from earlier years in Europe PMC. This may also be extended to other interested Europe PMC funders. Collaborative eﬀort Global grant ID Grant record Grant metadata Wellcome, as one of the Europe PMC funders, provides grant data to Europe PMC, which is displayed on the website and accessible via an open API To register a global grant ID, Europe PMC provides grant metadata to Crossref. Crossref registers a global grant ID in the form of a DOI. The DOI resolves to the grant record in the Europe PMC grant database. Grant DOI suﬃx	poster
Showcase #2 EPDraCor 󰏅 ●from the Early Print Library (~850 items, earlyprint.org) ●automated pipeline for importing texts and removing linguistic markup ●manual speaker disambiguation through a dedicated web service ●sneak preview: staging.dracor.org/ep Showcase #1 UDraCor 󰑒 ●from a curated list of canonical Ukrainian drama (~150 items) ●plain texts fetched from non-scholarly online libraries ●ezdrama markup applied by a group of volunteers ●sneak preview: staging.dracor.org/u Onboard onto DraCor! Prototyping Workﬂows to Homogenize Drama Corpora Ingo Börner x Frank Fischer x Luca Giovannini Christopher Lu x Carsten Milling x Daniil Skorinkin Henny Sluyter-Gäthje x Peer Trilcke Project homepage: dracor.org 🦜 Texts with no markup (e.g. TXTs from OCRed PDFs) Matrosen. Wie? Kommt ihr denn nicht selbst an Bord? Python scripts ad-hoc transformation pipelines XSLT (or Python scripts) ezdrama a simple, markdown-like language for conversion to XML DraCor-ready TEI-XML Texts with basic markup (e.g. HTMLs) <i>Matrosen.<i> Wie? Kommt ihr denn nicht selbst an Bord? Texts with advanced markup (e.g. XMLs) <sp who="#matrosen"> <speaker>Matrosen. </speaker> <l>Wie? Kommt ihr denn nicht selbst an Bord?</l> </sp>	poster
Ted Laderas1,Nicole Vasilevsky1,2, Melissa Haendel1,2 , Shannon McWeeney1, David A. Dorr1,3 1Department of Medical Informatics and Clinical Epidemiology, 2Library, 3Department of Medicine, Oregon Health & Science University, Portland, OR ACKNOWLEDGEMENTS: This work is supported by NIH Grant 1R25EB020379-01 Get real: A synthetic dataset illustrating clinical and genetic covariates Goals Decision Trees for Generating Realistic Data Scenario Discussion Questions Next Steps Sample Datasets and the generation script will be made open-access and open-source on GitHub. We encourage collaboration to improve this idea. www.ohsu.edu/bd2k v Decision Trees provide framework for integrating clinical and genetic datatypes, but they are overly simplistic. v How difficult do we make the problem? v Tradeoffs between learning and difficulty v How can we incorporate other techniques such as natural language processing (NLP) into this task? v What are other scenarios we can model? v What extra covariates should we include for clinical and genetic data? v Should they be extraneous or collinear with other variables? v Develop a script to generate realistic synthetic datasets for hands-on learning in BD2K workshops v Learn the difficulties and challenges of working with both clinical data and genetic data v Learn the strengths/weaknesses of machine learning algorithms for classification in a “safe context” v Highlight known issues with integrating clinical and genetic data Learning Objectives Use predetermined decision tree structure to define structure of dataset Decision Tree Structure defines what risk groups exist in dataset Frequencies of risk groups derived from real patient data Risk group frequencies determine sampling probability of that risk group in synthetic dataset Tuning Difficulty Level Difficulty of problem can be tuned by adjusting conditional probabilities of CVD risk association for each risk group Variable Importance/level Age 1 BMI 2 Hypertension 2 Type 2 Diabetes 3 Race 4 Cholesterol 5 Gender 6 SNPs 6 v Task is a classification problem, where students predict (low or high) cardiovascular risk (< or =>7.5%/10 years), given the following data: v Clinical Data derived from Electronic Health Record systems (EHRs) v Lab Values (LOINC) v Medications (RxNorm) v Genetic data modeled as SNPs v Task structure is to train a model using initial set, then test algorithm on (hidden) set v To synthesize data, we use variable ‘importance’, defined as population affected and predictive impact determines level in decision tree Reference Parameters The Look AHEAD Research Group. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia. 2015;58(8):1803-1813. doi:10.1007/s00125-015-3610-z. For More Information AGE > 50 Hypertension = Y BMI > 25 T2D = Yes Smoking = Yes SNP1variant = GG,GA Cholesterol Treat = Y Race = Caucasian Cholesterol = High Race = Caucasian 1 T F T F 2 3 4 5 6 7 8 9 10 11 T F Genetic Data modeled as “surprise” risk groups Decision Tree branches define restrictions on sampling space for covariates Risk Group Group Definition Frequency P(CVD=High) 1 Age >50,Hyp=Y,Race=C 0.310 0.81 2 Age >50,Hyp=Y,Race=NC, Chol=H, CholTreat=Y 0.001 0.10 3 Age >50,Hyp=Y,Race=NC, Chol=H, CholTreat =N 0.001 0.20 4 Age>50,Hyp=Y,Race=NC, Chol=Low 0.010 0.70 5 Age>50, Hyp=N 0.280 0.08 6 Age<50, BMI>25, T2D=Y 0.166 0.78 7 Age<50, BMI>25, T2D=N 0.220 0.20 8 Age<50, BMI<25, Smoking = Y 0.010 0.60 9 Age<50, BMI<25,Race=C 0.010 0.01 10 Age < 50, BMI<25, Race=NC, SNP1=GG,GA 0.001 0.20 11 Age<50, BMI<25, SNP1=AA 0.001 0.05 T F T F T F T F T F T F T F v Difficulty of problem can be refined using iterative testing framework v Can refine probabilities, estimate difficulty from ROC curves, and recalculate dataset until desired difficulty reached	poster
It’s not limited to Archaea – on methane emissions in the world of fungi Tomasz Grzyb1 Lenhart et al. (2012) and Schroll et al. (2020) proved aerobic methane production in 8 Basidiomycota species: • Pleurotus sapidus • Laetiporus sulphureus • Lentinula edodes • Hypholoma fasciculare • Pycnoporus sanguineus • Phanerochaete chrysosporium • Pleurotus ostreatus • Trametes versicolor Huang et al. (2022) proved that facultatively anaerobic Schizophyllum commune 20R-7-F01, isolated from ~20-million-year-old deep subseafloor coal-bearing sediments, can anaerobically degrade and convert lignite, lignin, phenol and benzoic acid too CH4 via a newly described halomethane-dependent pathway. Methane – a potent greenhouse gas } Methane (CH4) is a powerful greenhouse gas, second only too carbon dioxide (CO2) in driving climate change during industrial times. It is a short-lived climate pollutant 28 times more powerful than CO2 over a 100-year timescale, the atmospheric amount of which has more than doubled since the pre-industrial era. The amounts of methane in the atmosphere have changed drastically in the past 40 years. Moreover, methane contributes too the formation of ground-level ozone (O3), a dangerous air pollutant with detrimental effects on people, ecosystems and crops. Methane sources can be broadly classified as biogenic, thermogenic and pyrogenic. A review Until recently, biogenic sources of atmospheric methane were attributed exclusively too anaerobic methanogenesis performed by methanogenic Archaea. There are three main methanogenic pathways: hydrogenotrophic, methylotrophic and acetoclastic (however, new ones are discovered). All methanogenic Archaea strictly rely on those processes for energy conservation and growth. Methanogenesis plays a quantitatively important role in global methane emissions. Fungi govern the decomposition of organic material, which is critical for the global carbon cycle. They can enhance archaeal methanogenesis e.g., by initiation of organic matter degradation – fungi release reduced substrates that may be channelled too methanogenesis. On the other hand, fungi may control methanogenic archaeal populations and/or biodegradate methane themselves. Those types of interactions were mainly described for: rumen microbiota wetlands anaerobic water treatment In 1977 a peak of CH4 in the oxygen -saturated water was discovered; it was already well-known that archaeal methanogenesis is inhibited by oxygen . Since that time, methane oversaturation in oxic aquatic environments is often observed ; this phenomenon is known as the „methane paradox”. There are at least a few possible explanations for those observations ; one of them is that other organisms can produce methane and they perform this in oxic environments. Nowadays, increasing evidence has confirmed that several groups of organisms can produce methane in processes other than methanogenesis: Methane (CH4) is responsible for ~30% of the rise of global temperature during the industrial era. The atmospheric concentration of CH4 is increasing faster now than at any time since the 1980s. CH4 is emitted both from natural and anthropogenic sources. There is growing evidence that biogenic methane production is not limited too archaeal methanogenesis and that other microorganisms produce methane, mostly aerobically. The knowledge of sources and sinks of CH4 is crucial too face the challenge of global climate change. It remains an open question whether those non-methanogenesis biogenic processes could be an important contributor too the global methane budget as we still lack estimates of CH4 emissions for various groups, fungi included. Methanogenesis Fungi interact with methanogenic Archaea Fungi produce methane Methane paradox aerobically anaerobically Stable carbon isotope labelling experiments revealed methionine as a methane precursor in fungi Fungi could produce CH4 via degrading various metabolites (such as methionine) as a stress response postulated reaction s	poster
BESIII Drift Chamber Tracking with Machine Learning 24th International Conference on Computing in High Energy and Nuclear Physics in Adelaide Yao Zhang1, Ye Yuan1, Ting Zhou2, Karimi Khozani Hosein1, Liqing Qin2 , Qiumei Ma1, zhangyao@ihep.ac.cn 1. Institute of High Energy Physics, CAS, Beijing, China 2. Guangxi Normal University, Guilin, China The Beijing Spectrometer III ( BESIII, Fig.1) has been running at the Beijing Electron Positron Collider II (BEPCII) for Tau-Charm physics since 2008. The tracking detector of BESIII is a Multilayer Drift Chamber (MDC). The tracking efficiency for high transverse momentum (pT) is high for charged particles but lower when (pT) < 120MeV/c as shown in Fig. 2. Some of the curling tracks with multi turn (\|cosq\|<0.2) have bad tracking efficiency and quality as Fig. 3 shows. For multi-turn tracks, the hits from different turns will close to each other and even overlap as Fig. 4 shows. The tracking efficiency is low due to effect of non-first turn’s hits. Network model U-Net is a convolutional networks for pixel level semantic segmentation. (https://arxiv.org/abs/1505.04597) Following is the U-Net model used in this work. Conv 33+RelU Max-pool Up-conv 33 Copy&concatentate Input event Output mask turn ID To learn the behavior of multi-turn tracks, the training sample should have multi-turn curling tracks which are at small dip angle and various transverse momentum. The particle used for this work are single m- and m+ . The track with transverse momentum less than 120MeV/c will curling in the MDC. Only track of more than one turn have been selected for the training and validation and testing. The momentum, angle and turn number distribution of data set show in the Fig. 6. Data sample The feature set to be the raw time of each hit after correction with the event start time. The cell without hits were set with a default time of 2000ns. The truth turn number from Monte-Carlo simulation used as target. The hits from the first turn were marked as 1. The hits from other turns and cells without hit were set to be the default value of 0. Dummy elements in the matrix were set to be the default values. Prepare for the input data The loss function used in this work is a binary cross entropy(BCE) plus a dice coefficient loss. Where 𝐵𝐶𝐸= −[𝑌log𝑓𝑋+ 1 −𝑌log(1 −𝑓(𝑋)]. Dice coefficient loss as a deep learning loss function for highly unbalanced segmentations. It was chosen because of the unbalanced number of element between 1st turn and non-1st turn. (https://arxiv.org/abs/1707.03237) Dice coefficient = 2\|𝑋∩𝑌\| 𝑋+\|𝑌\|, loss=1-(Dice coefficient)+BCE. Where, X is the target matrix and Y is the prediction matrix. So in this work,\|X\| and \|Y\| are approximately equal with the number of true first turn’s hits and predicted first turn’s hits respectively,\|𝑋\| ∩ \|𝑌\| is approximately equal with the number of hits marked as first turn hits and predicted as first turn hits. Loss function A sample of 10 thousands track have been used for training. The data set was separated into 7500 tracks for training and 2500 tracks for validation. The batch size was 64 and the epoch number was 50. Following are the training loss and model accuracy v.s. epoch number. The training has converged after about 15 epochs for validation data set. Training The efficiency and purity have been evaluated for single m- track with validation sample. The definition of efficiency and purity show as following: Efficiency = 𝑇𝑃 𝑃, Purity= 𝑇𝑃 𝑃′. Where TP is the number of predicted first turn and marked as first by Monte-Carlo truth, P is the number of true first turn hits and P’ is the number of hits predicted as first turn. The ROC curve of the average hit efficiency and purity (Fig. 10) shows that at the threshold of about 0.85 the prediction gives the efficiency and purity are about 91%. Fig.11 shows more than half of the events have efficiency and purity greater than 95%. From the event display (Fig.12) we can see that the efficiency of the hits from	poster

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