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NHS – Implementation and Delivery DHSC -policy and funding UK health security agency- public health surveillance RCGP- guideline and best practice BSAC – research and advocacy WHO global coordination and leadership Antimicrobial stewardship: Promoting responsible use to Combat resistance: The UK’s initial 5-year AMR strategy (2013-2018) was followed by the 20-year AMR vision and the second National action plan 2019-2024 To prevent antibiotic resistance [02] ❖AMR is creating a new generation of "superbugs" that are untreatable by current drugs, generating financial, health, food, environmental, and socioeconomic problems. [05] ❖ AMR harms public health and modern medicine by making infection treatment difficult or impossible, increasing morbidity, mortality, and healthcare costs.[04] ❖This multi-sectoral strategy coordinates efforts to optimise antimicrobial usage, minimise antibiotic use, and increase infection prevention, surveillance, and innovative therapy development.[01] ❖The partnership uses a "One Health" strategy across sectors to fight AMR, understanding its complexity and establishing realistic goals.[06] ❖The partnership seeks to build confidence among varied stakeholders while preserving their organisational independence and duties [07] Disabling Factors ❖The partnership's high-profile position in AMR and public health concerns may raise attention and pressure, altering decision-making and operations [07] ❖Guiding. The alliance has strong governance systems, with global Leaders Group quadripartite organisations coordinating and the [06] Enabling Factors ❖Ideological alignment might restrict the range of techniques and viewpoints required to solve a complicated, multi-sectoral problem.[07] Recognise and Accept the Need for Partnership Given the agencies' various aims and operational frameworks, the collaboration recognises the need for a single strategy but struggles to get partner commitment. [01] Develop Clarity and Realism of Purpose The many AMR problems may lead to unrealistic expectations, therefore realistic and adaptive goals are needed to respond to continuing reviews.[01] Ensure Commitment and Ownership Despite conflicting objectives and financial restrictions, long- term commitment demands continual involvement and resource allocation to sustain momentum.[03] Develop and Maintain Trust is fragile and needs constant communication, dispute resolution, and shared success to survive.[01] Create Clear and Robust Partnership Arrangements Formal structures must be reviewed often to adapt to changing conditions and new problems.[01] Monitor, Measure, and Learning Effective assessments and responsive initiatives depend on accurate and timely data from all partners.[01] Through stakeholder coordination, the UK AMR Partnership combats antimicrobial resistance. Despite difficulties sustaining long-term commitment and realistic expectations, it shows good teamwork, defined goals, and comprehensive monitoring. AMR prevention requires continual participation and flexibility. Aim Reduce Misuse and Overuse: Promote antimicrobial stewardship in healthcare and agriculture. [08] Aim Surveillance and Research: Increase antimicrobial resistance monitoring and encourage innovative therapy and diagnostic research.[04] Aim Increase Public and Professional Knowledge: Raise public and healthcare professional knowledge of AMR to promote appropriate antimicrobial usage. [04]
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RESEARCH IMPACT 2.0 ANALYSIS OF NEW TRENDS IN SCHOLARSHIP METRICS Daniela Solomon, Research Services Librarian Kelvin Smith Library, Case Western Reserve University INTRODUCTION Impact is defined as 'the demonstrable contribution that excellent research makes to society and the economy‘1. However, quantifying impact is a difficult task because there is uncertainty in how to define excellence in research, what aspects to take in consideration when evaluating a scholar, and how impact could be demonstrated. Impact metrics have become more important than ever and could affect hiring decisions, promotion and tenure, status among peers, university rankings and academic funding. First attempt at measuring impact was the number of citations based on the implication that what is cited must be good. Citation analysis applies to authors, papers, journals, and institutions. Citation analysis has many flaws and created many controversies (ie, using journal impact factor in evaluating scholars). As a result, citation analysis is deemed insufficient. Moving away from citation analysis is the developing trend altmetrics, which attempts to assess impact based on social web activity. As such, altmetrics constitute an improved answer to public’ expectations for speed, collaboration and openness, and allow the inclusion of new types of scholarship. However, it is argued that altmetrics measure the “reach” and not the quality, and that there is limited availability of data. Altmetrics complement bibliometrics, and the combination of citation analysis with altmetrics could offer an enhanced image of a scholars’ “impact.” MEASURING IMPACT ALTMETRICS CONCLUSIONS Three factors contribute to increased impact metrics: VISIBILITY “It’s not about where you publish, but who you reach.” Cameron Neylon CONSISTENCY “Researcher identification: the right needle in the haystack”12 AVAILABILITY “Not only are items difficult to find but, once found, they often disappear without notice”13 MAXIMIZE IMPACT • write to be discovered • retain copyright • publish in open access publications2-4 • publish works in digital repositories • use social media to disseminate information on your papers and research5-8 • post datasets on the Web9 • post other types of documents (images, illustrations, slides, specimens, etc) on the Web10 • claim incorrect citations to your papers11 • use an unique ID12 • collate scholarly profile • get permanent identifiers13-14 REFERENCES Presented at ALAO 2013 October 25, 2013 Image credits: altmetrics: a manifesto http://altmetrics.org/manifesto/ BIBLIOMETRICS 1. Research Counsils UK. Knowledge Exchange and Impact. Available from: http://www.rcuk.ac.uk/kei/Pages/home.aspx 2. Gargouri, Y., et al., Self-Selected or Mandated, Open Access Increases Citation Impact for Higher Quality Research. PLOS ONE, 2010. 5(10): e13636 doi:10.1371/journal.pone.0013636 3. Moed, H., Does open access publishing increase citation or download rates? Research Trends, 2012(28 - May 2012). Available from: http://www.researchtrends.com/issue28-may-2012/does-open-access-publishing-increase-citation-or-download-rates/ 4. Eysenbach, G., Citation Advantage of Open Access Articles. PLOS Biology, 2006. 4(5): e157. doi:10.1371/journal.pbio.0040157 5. Priem, J., Costello, KL., How and why scholars cite on Twitter., in American Society for Information Science & Technology Annual Meeting. 2010. Available from: https://docs.google.com/a/case.edu/presentation/d/15J41q9EzK3CiMMoIPKY545ACndORpa6Wtj75v1YjrzQ/edit#slide=id.i0 6. Groth, P., Gurney, T. Studying Scientific Discourse on the Web using Bibliometrics: A Chemistry Blogging Case Study. in Proceedings of the WebSci10: Extending the Frontiers of Society On-Line, April 26-27th, 2010, Raleigh, NC. Available from: http://journal.webscience.org/308/ 7. Thelwall, M., et al., Do Altmetrics Work? Twitter and Ten Other Social Web Services. PLOS ONE, 2013. 8(5): e64841 doi:10.1371/journal.pone.0064841 8. Allen, H.G., et al., Social Media R
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تغييرات رنگيزه هاي فتوسنتزي و تركيبات فنلي و فﻼونوئيديLemna minor تحت تيمار كروم معصومه اصﻼن زاده ، عذرا صبورا :* ،گروه علوم گياهي، دانشكده علوم زيستي، دانشگاه الزهرا تهران- ونك- ايران مقدمه: فلزات سنگين بعنوان سمي ترين آﻻينده هاي محيط زيست شناخته شده اند كه در نتيجه فعاليت هاي مختلف انساني به آب هاي سطحي و زير زميني آزاد مي شوند. در مطالعات گوناگون توانايي گياهان جنسLemna در جذب فلزات سنگين بررسي شده است. در اين پژوهش براي بررسي تاثير آلودگي فلز سنگين وم كر ) Cr ( و قدرت گياه پاﻻيي عدسك ،آبي ) Lemna minor (، اين ماكروفيت آبزي به مدت روز ٧ در معرض غلظت هاي مختلف كروم شش ظرفيتي ) mg/L ٠٠١-٠ ( در محيط كشت هوگلند رقيق قرار گرفت. سنجش محتواي ،كلروفيل تركيبات فنلي و فﻼونوييدي تام عدسك آبي تحت تيمارmg/L ٠٠١- ٠٥ نشان دهنده ي آسيب پذيري گياه در اين غلظت ها بود. كد مقاله : bio3- 06930446 مواد و روش: يافته ها : •تغييرات ظاهري سطح برگ ،ها مانند ،كلروز جدا شدگي برگها از ،هم از روز سوم مشهود بود )شكل زير( و تا پايان دوره آزمايش ميزان كلروز در تيمارهاي ٠١، ٠٥ و ٠٠١ ميلي گرم در ليتركروم به نسبت ،شاهد به ترتي ب حدود ٠١%، ٠٥% ٠٨ و% افزايش يافت. • كاهش معني دار محتواي كروم باقيمانده در محيط كشت ٤٢ ساعت پس از تيمار به نحوي كه در پايان روز هفتم، غلظت كروم باقيمانده در محيط كشت به ويژه در تيمار ٠٥ ميلي گرم در ليتر كروم ٠٤ % كاهش يافته بود . با افزايش غلظت كروم در محيط كشت، محتوي كلروفيلa، b ، و كلروفيل كل و محتوي تركيبات فنلي و فﻼونوئيدي كاهش يافت. بحث و نتيجه گيري: در غلظت باﻻي فلز ،سنگين كاهش محتوي كلروفيل ها مي تواند به دليل تاثير بازدارنده فلز سن گين بر فعاليت آنزيم هاي مسير بيوسنتز كلروفيل و فعاليت كلروفيﻼز باشد. تركيبات فنلي و فﻼونوئيدي با پاكسازي راديكال - هاي آزاد قدرت آنتي اكسيداني گياهان را افزايش مي دهند. كارآيي گياه پاﻻيي اين گياه در حضور غلظت هاي پايين كروم چشمگير بوده اما غلظت هاي باﻻتر روم ك در بلند مدت منجر به مرگ سلول ها مي شد. Uysal نيز طي تحقيقات خود روي عدسك ،آبي در ٤٢ ساعت اوليه تيمار بيشترين ميزان جذب فلز سنگين كروم و سرب را مشاهده كرد. برخي منابع: 1.Beketov MA (2005) Species composition of stream insects of northeastern Altai: mayflies, caddisflies, and stoneflies (Ephemeroptera, Plecoptera, and Trichoptera). Euroasian Entomological Journal 4, 101–105. 2.Chandra, P., Kulshreshtha, K. (2004) Chromium Accumulation and Toxicity in Aquatic Vascular Plants. The Botanical Review 70(3): 313-327. 3.Choudhury S, Panda SK (2005) chromium stress in plants.Braz J. Plant Physiol., 17(1):95-102. 4.Frick, H. (1985) Micronutrient tolerance and accumulation in the duckweed, Lemna. Journal of Plant Nutrition, Vol.8,1985-Issue 12. شستشو با هيپوكلريت سدي م ١ % و انتقال به محيط كشت هوگلن د باpH 5.5 گياه عدسك از محيط زيست طبيعي، تاﻻب ،سراوان رشت جمع آوري شد اناليز داده ها بانرم افزار SPSS تيمارگياه ٠ با ،١ ، ٠١ ،٠٥ ،٠٠١ ميلي گرم در ليتركروم (K2Cr2O7) نمونه برداري از محيط كشت ٢١، ٤٢ ،٨٤ ، ٦٩،٢٧ ،٠٢١ و ٨٦١ ساعت پس از تيمار برداشت گياهان در روز هفتم و سنجش باقيمان ده كروم در محيط كشت با دستگاه ICP(OES) سنجش محتوي رنگيزه هاي فتوسنتزي و محتوي تركيبات فنلي تام
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Contact Mag.med.vet. Cynthia Sohm: cynthia.sohm@vetmeduni.ac.at Acknowledgements This project was founded by the federal state of Lower Austria. Grant number WST3-F-5033836/001–2020 • Isolate and genotype circulating Leptospira strains from cattle in Austria, to enhance the performances of the serological diagnostic test for humans and animals. • Further the understanding of the local epidemiology of this zoonotic disease. Goals • Inclusion criteria: a) High-risk farms: Farms presenting two of these four characteristics: > 34 head of cattle on the farm, introducing new cattle (buying), access to pasture, history of abortions. b) Symptomatic cattle: Cattle presenting one of these six symptoms: abortion, fertility disorder, photosensitisation, icterus, haematuria, decrease in milk yield. Older cattle were prioritised, no systemic antibiotic treatment within two weeks prior to the sampling. • PCR: • 5/410 (1.2%) cattle positive. • Six urine samples (from four cattle) and three kidney samples. • Sequencing lfb1 gene: Successful in 5/6 urine samples: all identified as Leptospira borgpetersenii. • Culture: • Three isolates from the three PCR positive kidney samples. • Growth detected after seven, 18 and 23 weeks of cultivation. • Required addition of foetal calf serum (FCS). • cgMLST: All three isolates were identified as Leptospira borgpetersenii serogroup Sejroe, serovar Hardjobovis [5]. Results • First isolation and subsequent genotyping of locally circulating pathogenic Leptospira in Austria. • Initial step towards enhancing the performances of the serological diagnostics for both humans and animals withing the country. • Cattle may act as carrier of pathogenic Leptospira in Austria. • Zoonotic potential of the identified circulating strain. Farmers, veterinarians & slaughterhouse workers at higher risk of infection. • Leptospirosis should be considered as differential diagnosis for bovine abortions in Austrian cattle. Conclusion 1 Haake DA & Levett PN. (2015). Leptospirosis in humans. In: Adler B, editor. Leptospira and leptospirosis. Current Topics in Microbiology and Immunology. Vol. 387. Berlin, Heidelberg: Springer Berlin Heidelberg. p. 65–97. 2 O’ Doherty E, et al. (2015). Effect of exposure to Neospora caninum, Salmonella, and Leptospira interrogans serovar Hardjo on the economic performance of Irish dairy herds. J Dairy Sci 98 (4): 2789–800. DOI 10.3168/jds.2014-8168 3 World Health Organization (WHO). Leptospirosis laboratory manual https:// www. who. int/ publi catio ns/i/ item/ B2147 (2007). 4 World Organisation for Animal Health (WOAH). 3.1.12 Leptospirosis in Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2022 https:// www. woah. org/ filea dmin/ Home/ fr/ Health_ stand ards/ tahm/3. 01. 12_ LEPTO. pdf (World Organisation for Animal Health, 2021) 5 Sohm C, et al. 2024. First isolation and genotyping of pathogenic Leptospira spp. from Austria. Sci Rep 14 (1): 1–9. DOI 10.1038/s41598-024-53775-w. References • Leptospirosis is a globally spread zoonotic disease, which mainly affects humans and mammals. • The disease is caused by pathogenic bacteria of the genus Leptospira. • In humans the symptoms range from mild, influenza-like syndrome to the potentially deadly Weil’s disease [1]. • In cattle, abortions and fertility disorders are common signs of infection. Therefore, leptospirosis can lead to significant financial losses [2]. • The microscopic agglutination test is the gold standard for the sero-diagnosis. The World Health Organization and the World Organisation for Animal Health recommend the inclusion of locally circulating strains in the panel of live strains [3,4]. • In Austria no local strain has been available for diagnostic purposes. Background • Targeted sampling: Based on a systematic literature review and analysis of national serological data. • Urine and/or kidney samples of: a) Routinely slaughtered cattle from identified high-risk farms located in Lower Austria, and b) Cattle from farms
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Website: https://daxfeliz.github.io/ Email: dax.feliz@vanderbilt.edu NEMESIS: Exoplanet traNsit survEy of nearby M-dwarfs in TESS FFIS Dax Feliz [1,2], Peter Plavchan [3], Samantha Bianco [1], Mary Jimenez [3] Kevin Collins [3] , Bryan Villareal Alvarado [4] and Keivan Stassun [1] Fisk University [1], Vanderbilt University [2] George Mason University [3], University of Costa Rica [4] - In this work, we’ve analyzed over 35,000 M-dwarf stars located within 100 parsecs of Earth that were observed in TESS Sectors 1 - 5 with 30 minute cadences. - Of those 35,000, we’ve identified 183 transit signals, 29 of which we’ve determined to be due to planetary eclipses. - The planet candidates we’ve detected have planet radii ranging from 1.26 - 5.31 Earth radii and orbital periods ranging from 1.25 to 6.84 days. - 24 of our 29 candidates are new detections! Project Summary From Images to Photometry to Transit Detection - Extract Raw photometry and remove short term instrumental effects by using a Pixel Level Decorrelation (PLD) algoritm based on Deming et al. 2015 - Remove long term stellar variations with a time-windowed median based smoothing function (Wötan, Hippke et al. 2019a). - Once the photometry is extracted and cleaned, we then perform an algorithmic search using Transit Least Squares (Hippke et al. 2019b) for the period range 1 - 9 days. Gallery of Detected Exoplanets Target Star Selection Criteria NEMESIS Photometric Precision All target stars are filtered using stellar parameters from TIC v8 - 2300 K < Effective Temperature < 4000 K - Stellar Radius < 0.5 Solar Radius - Stellar Mass < 0.5 Solar Mass - Logg > 3 - Distance < 100 parsecs - Targets are also cross referenced with the TESS Candidate Target List (CTL, Muirhead et al. 2018). Green borders are TOIs Grey space marks the ranges between the radius valley radius-period slopes for Sun-like stars to low mass stars 60 ppm hr -1/2
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Non-reproducibility of scientific studies (e.g. 64% in pharmacological studies [2], 89% in cancer [3], and 66% in psychology [4]) is often due to imprecise specification of the scientific protocol in publications. To address this issue, we develop methods to apply the FAIR data principles to protocols and workflows. Specific research questions are: 🡪 How can workflow and protocol specifications, e.g. standard operating procedures, be published as FAIR data? 🡪 How to abstract from concrete workflow to general protocol specifications (e.g., with semantic templates) to improve reproducibility? 🡪 How to model and integrate non-computational steps in workflow and protocol specifications? FAIR Workflows Data publishing of scientific protocols João Moreira1, Tobias Kuhn1, Michel Dumontier2, Remzi Celebi2 , Ahmed Hassan2, Harald Schmidt2, Lars Ridder3 , Valentina Maccatrozzo3, Roel Zinkstok3, Carlos Martinez3 1 University VU Amsterdam, Netherlands. 2 Maastricht University, Netherlands 3 Netherlands eScience Center, Netherlands Motivation and research questions [1] Vasilevsky, N. A., Brush, M. H., Paddock, H., Ponting, L., Tripathy, S. J., LaRocca, G. M., & Haendel, M. A. (2013). On the reproducibility of science: unique identification of research resources in the biomedical literature. PeerJ, 1, e148. doi:10.7717/peerj.148 [2] Prinz, F., Schlange, T., & Asadullah, K. (2011). Believe it or not: how much can we rely on published data on potential drug targets? Nature Reviews Drug Discovery, 10(9), 712–712. doi:10.1038/nrd3439-c1 [3] Begley, C. G., & Ellis, L. M. (2012). Drug development: Raise standards for preclinical cancer research. Nature, 483(7391), 531–533. doi:10.1038/483531a [4] Klein, R. A., Ratliff, K. A., Vianello, M., Adams, R. B., Bahník, Š., Bernstein, M. J., Brumbaugh, C. C. (2014). Investigating Variation in Replicability. Social Psychology, 45(3), 142–152. doi:10.1027/1864-9335/a000178[ Requirements based on user stories 🡪 Platform that supports reproducing experiments and their results 🡪 Share workflows in findable data repositories (FAIR data points) 🡪 Use community standards and tools to share workflows 🡪 Detailed specification of computational and manual workflow steps 🡪 Track workflow executions with versioning and provenance Preliminary results 🡪 Workflow ontology and semantic templates for metadata management 🡪 Common Workflow Language (CWL) for interoperability of workflow systems 🡪 FAIR technologies: Data Points, Nanopublications, Projectors and Accessors 🡪 Prototype plug-in for IPython/Jupyter notebooks Validation 🡪 Case studies and user study with drug repositioning and systematic reviews Impact Domain-agnostic: applicable to other fields to improve reproducibility in a vast area of scientific research Pharmaceutical research efficiency: improve identification of cardiovascular drug candidates Approach Workflow step operations edam:QueryAndRetrieval edam:Parsing edam:Mapping edam:DataHandling edam:Aggregation edam:NetworkSimulation obi:SimilarityCalculation mls:HyperParameterSetting mls:ModelEvaluation obi:WesternBlotAnalysis edam:EnrichmentAnalysis edam:PathwayOrNetworkVisualisation P-PLAN SIO: Semanticscience Integrated Ontology Ontology engineering 🡪 Systematic literature review of existing ontologies and gap analysis 🡪 Ontology-driven conceptual modelling and ontology alignments 🡪 Proof-of-concept: semantic wrapper (proxy) DOLCE+DnS Ultralite (DUL) OpenPREDICT use case 🡪 Machine learning algorithm for cardiovascular drug repositioning 🡪 IPython/Jupyter notebook
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Apache Point Observatory Kepler Pseudo-Haiku Abstract Sleepy fat old suns, Not Always though. Not for them: Couples, merged, massive. Patrick Gaulme1, Federico Spada1, Jason Jackiewicz2 1 Max Planck InsKtute for Solar System Research 2 New Mexico State University During the main sequence, stars with a convecKve envelope (M≤1.3Msun) lose spin while aging because their surface magneKc fields carry angular momentum away. Intermediate-mass (1.3≤M≤3 Msun) do not lose such spin. However, a small fracKon of red giants display (large) v sini ≥ 10 km/s (e.g., Carlberg+2011 [1]). We expect the intermediate-mass stars to show large v sini but they are missing in recent surveys of acKve red giants (e.g., Ceillier+2017 [2], Tayar & Pinsonneault 2018 [3]). Photometric measurements of spoby (spinning) stars exhibit pseudo* periodic modulaKons *“Pseudo” because spots evolve As they enter the red giant phase stars spin down by convecKve envelopes expanding and gefng (Gaulme+2020, A&A 639, 63) 3+ years of photometric data of the 4500 brightest red giants observed by the NASA Kepler mission. A subsample of ≈ 100 red giants monitored with the échelle spectrometer of the 3.5-m telescope at Apache Point Red giant branch Red clump RESULTS: the magneKcally acKve red giants split into three groups: 1) red giants in close binary systems spun-up by Kdal forces; 2) solar-mass clump stars that engulfed a stellar/substellar companion on the red giant branch; 3) intermediate-mass stars that were fast rotators on the main sequence. Radial velocity variaKons + Chemical abundances References [1] ApJ 732, 39 [2] A&A 605, 111 [3] ApJ 868, 150 Database The Gaulme+2020 asteroseismic analysis is on the CDS. § Red giants in close binaries exhibit photometric variaKons 10x larger than the single ones with same spin rate. Why that? § Despite having surface magneKc fields, intermediate-mass stars have spin rates lower than expected. When and how angular momentum vanished? § About 10% of our spectroscopic red giants are lithium rich, but there is no correlaKon with any of the 3 types of magneKcally acKve red giants
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CEPLAS – Cluster of Excellence on Plant Sciences – is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy – EXC-2048/1 Cooperation: Publications: One Resource to Teach Them All Dominik Brilhaus1, Martin Kuhl2, Cristina Martins Rodrigues3, Andrea Schrader4 (in alphabetical order) 1: Data Science and Management, CEPLAS, Heinrich Heine University Düsseldorf, Germany, 2: Computational Systems Biology, DataPLANT, University of Kaiserslautern-Landau, Germany, 3: eScience, DataPLANT, University of Freiburg, Germany, 4: Data Science and Management, CEPLAS, University of Cologne, Germany Teaching materials are often scattered, hard to find, and fragmented. We follow the principles of Open Educational Resources (OER) promoting easy access to educational materials and increased chances of educational equity[1]. A central collection of materials allows the respective community to add and improve contributions with transparent and traceable authorship and licensing of contents. We aim at one adaptable OER for all: a light-weighed, central, reusable, open and contribution-open resource of materials for varying learning environments. Therefore, we develop a teaching material resource based on the concept of annotated bricks along didactic paths for DataPLANT. Motivation Screenshot of the DataPLANT teaching-materials-concept GitHub repository. Implemented and further developed in the DataPLANT Knowledge Base: https://nfdi4plants.org/nfdi4plants.knowledgebase/ § Individual slides/text/paragraph § Smallest possible educational content snippet § Coherent building blocks - slide decks § Cover a complete idea, thought or topic § Combined building blocks § Composed along a didactic path adapted to a learning environment, target group or person 3 Levels Balance Customisation & Reuse Modular concept for the DataPLANT OER. § Inspired by previous recommendations[2,3] § Aggregated YAML front matter § In markdown files along didactic path upon compilation. § Didactic Path § Ordered list of paths to bricks, units, disseminations § May contain metadata in a levelled YAML header § Suggested Tools § Design: VS Code + Marp extension § Collaborate: Git + GitLab/GitHUB § Compile / Convert: (Py)MarpCombiner + Marp CLI Metadata: From Bricks to Disseminations Left: Didactic path example with paths relative to the root of the repository. Another option: paths relative to the output location. Right: Example “version control using Git” to elaborate our levelled concept. We acknowledge the support of DataPLANT, funded by the German Research Foundation (DFG) within the framework of the NFDI – project number: 442077441 & CEPLAS, funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) within Germany´s Excellence Strategy – EXC-2048/1 – project ID 390686111. References: 1: UNESCO (2022) UNESDOC Digital Library, Catalog Number 0000383205, accessed: Apr. 21, 2023. 2: Garcia, L et al. (2020) PLoS Comput Biol, vol. 16, no. 5, e1007854 3: Batut, B et al. - PURL: https://gxy.io/GTN:T00062, accessed: Apr. 21, 2023 Collaborations: Visit the Concept Repository Bricks Disseminations Units Didactic path
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Sample Selection We selected a sample of AM CVn targets from the collection of G. Ramsay et al. (2018) [4]. The NAVOO Project: photometry for AM CVn candidates Fig. 3. BinaPhot results for an observation night of ASASSN-14mv in Open filter. AM CVn Cataclismic Binary Systems AM Canum Venaticorum (AM CVn) systems are a unique subclass of cataclysmic variables where two DB white dwarfs exchange hydrogen-depleted material (Figure 1). They are characterized by their short orbital periods ranging from 5 to 65 minutes. These systems display superhump periodicities, resulting in a broad range of photometric variability. The number of known AM CVn systems has significantly increased from just 4 in the 1990s [1] to 70 today [2]. Despite this growth, Roelofs et al. (2007) predicted a much larger galactic population of 3x105 - 3x106 AM CVn systems [3]. Furthermore, only about 60 of the currently catalogued candidates have well- determined orbital periods, highlighting the importance of each new characterization. The Nice AM CVn Optical PrOject (NAVOO) was created for revisiting known AM CVn targets to obtain or refine their physical parameters. This project has already been granted observation time: four nights of photometry with the small-size telescopes at the Observatorio del Teide (the IAC80 and Carlos Sánchez Telescopes), and one night of spectroscopy with the Isaac Newton Telescope (INT) at the Observatorio del Roque de los Muchachos. Source Period (mins) Outbursts? Mag. Range (filter) ASASSN-14mv 41:(sh) Yes 11.8(V)-18.1(V) ASASSN-14fv ? Yes 14.6(V)-20.5(B) PU Aqr (SDSS J2047+0008) ? Yes 17.0-24 Gaia16all ? Yes 16.2-20.6(G) PTF1 J1523+1845 ? Yes 17.6-23.5 CRTS j0844-0128 ? Yes 17.4-20.3 DGMetrix DGMetriX is a set of user-friendly PyRAF scripts [6] for image reduction and photometric analysis of eclipsing systems. They all have been designed to fit any telescope and set of filters, thus providing a uniform way of obtaining differential photometry for diferent observations. • PhotoRed: Script to perform the reduction process, based on bias and overscan substraction, and flatfield correction. • AstroNet: The astrometrization process is done using Astrometry.net [7]. The script automatically detects the stars of the image and saves the astrometrization results in the images headers. • BinaPhot: The core of the script uses daophot to perform differential photometry. Some important corrections (i.e. airmass calculation, mean-FWHM computation) are applied to obtain small photometric variations. First BinaPhot results for ASSAN-14mv are shown in Figure 3. More observations are required in order to refine the period. Fig. 1. Artistical representation of a standard AM CVn system. Fig. 2. Average spectrum of ASASSN-14mv from WHT. Spectral Data Spectra for ASASSN-14mv were already taken and will be soon reduced and compared with those acquired by J. Green et al. (2020) [5] (Figure 2). References [1] Ulla, A. (1994). The AM CVn systems: A bibliographic search for clues to their cataclysmic nature. Space science reviews, 67(3), 241-362. [2] Pichardo Marcano, M., Rivera Sandoval, L. E., Maccarone, T. J., & Scaringi, S. (2021). TACOS: TESS AM CVn Outbursts Survey. Monthly Notices of the Royal Astronomical Society, 508(3), 3275-3289. [3] Roelofs, G. H. A., Nelemans, G., & Groot, P. J. (2007). The population of AM CVn stars from the Sloan Digital Sky Survey. Monthly Notices of the Royal Astronomical Society, 382(2), 685-692. [4] Ramsay, G., Green, M. J., Marsh, T. R., Kupfer, T., Breedt, E., Korol, V., ... & Aungwerojwit, A. (2018). Physical properties of AM CVn stars: New insights from Gaia DR2. Astronomy & Astrophysics, 620, A141. [5] Green, M. J., Marsh, T. R., Carter, P. J., Steeghs, D., Breedt, E., Dhillon, V. S., ... & Wild, J. (2020). Spectroscopic and photometric periods of six ultracompact accreting binaries. Monthly Notices of the Royal Astronomical Society, 496(2), 1243-1261. [6] Science Software Branch at STScI. PyRAF: Python alternative
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Co-Creative Decision-Makers for 5.0 Organizations Value Co-Creation Labs 6 national networks of socio-economic actors dedicated to 5.0 collaborative value creation will be established. The VCC Labs are physical installations based on the Digital Innovation Environment powered by OMiLAB, enhanced with 5.0 resources that facilitate multi-stakeholder collaboration. Innovation Boosters and Catalyzers A knowledge sharing platform dedicated to support both BOOSTERS (collaborative 5.0 networks and initiatives among socio-economic actors) and CATALYZERS (learning and educational activities for the certification and development of knowledge, skills and competences) will be developed. 30 cases studies of 5.0 collaborative innovation projects will be implemented, emphasized by an annual International Prize of Innovation. 5.0 Certification A unique European Open Badge Certification for Decision-Makers for 5.0 Organization will be created and experimented, with an objective of more than 450 badges at the end of the project. Materials and methodologies, covering knowledge, skills and competencies with a unique development frame, shared by all sectors of application (health, agritechnology, industry) are included. Educational and Vocational Training The learning content required for 5.0 organizational Decision-Makers is collaboratively designed by Higher Education Institutions (HEI) and Vocational Education and Training (VET) facilities, supported by the industry partners with case-study and praxis examples. 8 vocational training offers and 11 academic training curriculum will be implemented and experimented through 6 European countries. Project Lead: Prof. Xavier Boucher Mines Saint-Etienne, France info@codemo-project.eu Follow & Join Us on the 5.0 Journey! Duration: Oct. 23 - Sept. 26 Project Number: 101104819 Our Partners: resilient . human-centric . sustainable
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New Immunofluorescence-Based Services CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has recently launched its new services based on immunofluorescence technology to provide researchers with diverse analysis and accurate results on fixed or fresh samples. These new services can be applied to the detection of circulating autoantibodies/antigens in cells and cell membranes/ immune complexes in biopsy material/circulating immune cells. Immunofluorescence is one of many techniques used in biomedical research and diagnosis. It uses the sensitivity and selectivity of fluorescence to analyze biological tissues. The basic reaction in immunology is the antigen-antibody reaction. When an antigen-antibody reaction occurs, the high specificity of the reaction means that once one factor is known, another factor can be identified. In the immunofluorescence technique, an antibody (or antigen) is labeled with a fluorochrome that does not interfere with the activity of the antigen and antibody, binds to its counterpart, and shows a specific fluorescent reaction under a fluorescence microscope. Immunofluorescence techniques can be used to detect proteins and other biomolecules in cells and tissues. Scientists can utilize immunofluorescence technology for a variety of laboratory tests and observations, providing a new perspective on the samples being analyzed. Researchers can also apply this technique to fixed or fresh samples to obtain multiple analysis and accurate results. CD BioSciences now offers customers with customized services based on immunofluorescence technology for scientific studies, including detection techniques of Fluorescence Microscopy, Laser Scanning Confocal Microscopy, and Flow Cytometry. The basic function of a fluorescence microscope is to transfer excitation energy to a fluorescent dye in the specimen, separate the weakly emitted fluorescence from the excitation light, and deliver it to a detector to produce a contrast image. The specificity and high sensitivity of Fluorescence Microscopy allow it to study cellular and subcellular structures in biological tissues at high resolution. It provides three-dimensional spatial information and temporal variation of spatial information in living cells. Confocal Microscopy is a well-established biomedical research tool that provides enhanced light microscopic imaging of cells labeled with fluorescent dyes. Its main application is the high-resolution analysis of subcellular components in three dimensions. The main difference to conventional epifluorescence microscopy is the imaging method. The former provides an image of the entire specimen, while Confocal Microscopy focuses on a single spot of light and scans the specimen line by line.
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FOR MORE INFORMATION lasar@canterbury.ac.uk www.epistemicinsight.com/ees We are working with partnership schools to investigate Big Questions! Have you ever stopped to think about how we gain knowledge?
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Processus d’apprentissages et de développement de compétences en situation informelle à travers l’utilisation des TIC Valérie Payen Jean Baptiste, Haïti, valeriejbpayen@gmail.com Doctorante, Université de Genève-TECFA, Suisse Brève présentation de l’étude: cette thèse est centrée sur l’étude des apprentissages réalisés en dehors d’un milieu formel. L’objectif est de rendre compte des processus d’apprentissages et de développement de compétences en milieu informel via l’utilisation des TIC. Pour explorer l’objet d’étude les pratiques des vendeurs et réparateurs évoluant dans le secteur économique informel en Haïti furent observés et analysés. Ces pratiques regroupent les activités d’appropriation, d’exploitation, et de transformations exercées sur et avec l’outil téléphonique par les acteurs du milieu, leurs modes d’organisations, de production et leurs processus de transmission de savoirs. Cadre théorique: Trois axes théoriques son mobilisées pour étudier le concept de l’apprentissage informel 1- Les systèmes d’activité humaine médiatisée par un artefact pour l’apprentissage de nouvelles compétences (Théorie instrumentale de Rabardel , 1995. Les théories des systèmes d’action, Leontiev, 1978; Vygosky , 1978; Engerström, 1987 2- L’influence des pratiques sociales sur le processus d’apprentissage (Les trois dimensions d’influence des pratiques sociales, Wenger, 2005). 3- Parcours de développement des compétences: les trois approches de reconnaissance des compétences (Le Bortef,1998). L’influence des trajectoires sur le développement des compétences Dominice, 1999 Méthodologie: Recherche ethnographique en immersion sur plusieurs sites d’observations différentes selon l’approche ethnographique itinérante multi située (Marcus, 1995) sur deux années consécutives : 2017 – 2019. Collectes des données - Entretiens, Observation participante et non participante audios via WhatsApp - Entretiens semi diriges. - Observation participante in situ - Enregistrements audios et vidéos. Analyse des données Analyse thématique descriptive et interprétative des données Vander Maren, 1996; Braun & Clark, 2006; Miles, M. B., Huberman, A. M., & Saldana, 2013 Question principale de recherche: quelles sont les actions, les interactions, les modes d’organisation, les trajectoires qui influencent l’apprentissage et le développement de compétences des vendeurs, des réparateurs et fabricants de téléphones mobiles sur le marché informel en Haïti ? FACULTÉ DE PSYCHOLOGIE ET DES SCIENCES DE L’ÉDUCATION
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Humanities for Change Un network sul futuro delle discipline umanistiche CHI SIAMO Humanities for Change è un network di giovani studiosi e studenti universitari che intende presentare un ideale alternativo per il presente e il futuro della cultura umanistica. L’assunto di base è che le discipline umanistiche debbano fuoriuscire dalle cerchie ristrette del dibattito accademico per divenire strumento dell’agire pratico e prerequisito essenziale per una società democratica. In questo modo possono offrire una maggiore consapevolezza della complessità propria delle problematiche di ordine politico, sociale ed economico. IL PUBBLICO Con la sua attività di divulgazione, il network si propone di raggiungere una vasta platea, non di soli esperti del settore. L’approccio contaminatorio e multidisciplinare di cui si avvale è perseguito con il costante utilizzo di più canali di comunicazione (social network, video, blog, rivista) in grado di intercettare diverse fasce di pubblico ed è favorito dalla distribuzione di tutti i contenuti con una licenza Creative Commons che ne incentiva la condivisione. ✦ Il blog di Humanities for Change, con i suoi articoli in italiano e/o in inglese pubblicati sul sito principale e sulla piattaforma di blog accademici Hypotheses, è uno spazio di dialogo dove i giovani specializzandi possono pubblicare i loro contributi. Accoglie anche le recensioni delle principali novità editoriali del settore. ✦ Grazie alla collaborazione con altre associazioni culturali, a partire dagli articoli di digital and public history proposti nel blog vengono realizzate alcune interviste a docenti ed esperti. In aggiunta a ciò, il network pubblica in autonomia podcast e brevi video su alcune tematiche di rilievo. ✦ Con il finanziamento degli enti universitari, il network realizza alcuni eventi nei quali un relatore esterno dialoga con un docente dell’università ospitante e con un collaboratore del network. Per raggiungere un pubblico più ampio, gli incontri sono trasmessi in streaming. ✦ L’ultima sfida (ancora in corso) è quella di realizzare una rivista scientifica internazionale, quadrimestrale, con un sistema di double-peer review. Accoglierà contributi in lingua inglese più corposi di quelli del blog e sarà distribuita in formato open- access su un nuovo sito e sui portali tematici di riferimento. INIZIATIVE E PROGETTI www.humanitiesforchange.org ✦ www.hfc.hypotheses.org ✦ info@humanitiesforchange.org CREDITS: SARTOR 2020
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MAPPING THE PATIENT JOURNEY: Understanding experiences and barriers to care in the context of poorly understood chronic illness. Natalia Duda¹ (dudan@tcd.ie), Dr Rebecca Maguire² & Dr Siobhán Corrigan¹ ¹ School of Psychology, Trinity College Dublin, Ireland ² Department of Psychology, Maynooth University, Ireland A N A L Y S I S Rich and detailed account of patients' lived experience. SURVEY LIFE GRID INTERVIEW Temporal aspects of the journey: Symptom onset, help-seeking, diagnosis, referrals, coordination of care Participant demographics Descriptive analyses Exploratory analyses Interpretative Phenomenological Analysis (IPA) C O N C L U S I O N S The present study provides a novel approach to exploring the lived experiences and journeys of patients with poorly understood chronic illness. By mapping patients' encounters with the healthcare system over time, it provides a pragmatic evaluation of healthcare quality, highlighting areas where improvements can be made to enhance patient- centred care. The study's findings will contribute to a broader understanding of the challenges faced by patients, emphasizing the significance of effective communication between patients and clinicians, especially in the face of medical uncertainty. Chronic illnesses with poorly understood or medically unexplained symptoms can be challenging for both patients and healthcare providers. Patients often experience lengthy healthcare journeys characterized by diagnostic and prognostic uncertainty, suboptimal communication, and strained consultation dynamics M E T H O D O L O G Y Snowball sampling methods Adults with poorly understood conditions Brief demographic questionnaire (online) Life grid (online or paper-based) Semi-structured interviews (virtual or in-person) A mixed-methods approach and participatory design to explore patients’ experiences of healthcare. Three components: THE LIFE GRID INTERVIEW O B J E C T I V E S To explore the journeys of patients with poorly understood chronic illness using Life Grid interview methodology; To describe and map patient pathways; To identify factors that act as barriers or facilitators to care. 1. 2. 3. R E F E R E N C E S Parry O, Thompson C, Fowkes G. Life Course Data Collection: Qualitative Interviewing using the Life Grid. Sociological Research Online. 1999 Jul 1;4(2):102–12. Richardson J, Ong BN, Sim J, Corbett M. Begin at the beginning… Using a lifegrid for exploring illness experience. Social research update. 2009;57:1-4. 1. 2. Preliminary analyses indicate suboptimal healthcare experiences among individuals with poorly understood illness. Participants described diagnostic delays, lengthy wait periods and poor continuity of care throughout their journeys. The complexity of patients’ narratives was captured by the life-grid. Figure 1 provides a visual depiction of one participant’s patient journey. P R E L I M I N A R Y R E S U L T S P A R T I C I P A N T S Participants completed a timeline outlining any significant or meaningful life events they could remember and the year/age at which they occurred. What was life like at the time? (friends, family, work) What was your health like at the time? What were your healthcare experiences like at the time? Around the time of each event identified..... Participants were invited to tell their story during an in- depth interview (virtual or in person). Follow-up questions concerned participants’ health over their lifetimes, with a focus on symptom onset, help-seeking, diagnosis, treatment and specific healthcare experiences. Emerging information was added to the life-grid during the interview Figure 1. Visual depiction of the patient journey captured by the Life Grid interview. 12 participants (8 Female, 4 Male) Age: 21-62 (M age=40) Conditions reported: ME/CFS, CRPS, FND, Lyme disease, POTS, MCAS, hEDS, Fibromyalgia, Sjögren’s syndrome B A C K G R O U N D The Life-Grid is a visual tool which can be used for exploring the narratives of individuals with chronic il
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Tracking manta rays We conducted 8 years (2013–2021) of monitoring to provide the most comprehensive description to date of a reef manta ray (Mobula alfredi) nursery Investigating Reef manta ray nursery in Wayag lagoon, Raja Ampat Edy Setyawan – Institute of Marine Science Cannot swim backwards Give birth to only 1 pup every 2-6 years Largest brain- to-body ratio of all fishes Live at least 50 years Size at birth: 1.5–1.9 m from wingtip to wingtip Have NO sting! Feed on zooplankton Males are smaller than females Keep swimming to breathe QUICK FACTS! Satellite telemetry (2015 & 2017) Aerial survey (including drone photogrammetry) Boat surveys Underwater surveys Passive acoustic telemetry (May 2019–Sept 2021) VR2W acoustic receiver stations (n = 5) Acoustic transmitters (n = 9) Satellite transmitters equipped with GPS (n = 5) Shelter from predators Social interaction & learning opportunity Sufficient food source Benefits of living in a nursery Cleaning stations like ‘spa’ A nursery is a good and safe environment contributing to higher chances of newborn survival! Palmyra Atoll Flower Garden Banks Florida Raja Ampat Nusa Penida The Maldives How to define a nursery for manta rays? See Criteria! Potential manta ray nurseries 1) are more commonly encountered in this area than in other areas 2) tend to remain and/or return to this area repeatedly for extended period** 3) inhabit the area across years As applied on manta rays, pups and juveniles: Criteria of an elasmobranch* nursery The ecology of newborn and juvenile manta rays is understudied Identifying critical habitats (i.e., nurseries) is urgently required to support conservation effort Most species of sharks and rays use shallow sheltered habitats like lagoons as nurseries for their newborns Residency and continuous occupancy of juveniles in the Wayag lagoon Home range and spatial movement pattern in and around the Wayag lagoon Application of drone to locate & measure manta rays, and collect their photo IDs Each manta ray has unique spot pattern on its underside, like our fingerprints Manta ray pups live independently without parental care immediately after birth Key references: Heupel et al 2007 Mar. Ecol. Prog. Ser. Heupel et al 2019 Mar. Freshw. Res. Setyawan et al 2020 J. Ocean. Sci. Found. Setyawan et al 2022 Drones Stevens 2016 PhD Dissertation, Uni. of York Contact: Edy Setyawan edy.setyawan@auckland.ac.nz CONCLUSIONS • We conclusively confirm that the Wayag lagoon in Raja Ampat serves as a nursery for newborn and juvenile reef manta rays • Our study presents the most robust assessment and comprehensive description to date of a manta nursery Satellite telemetry • Restricted movements within Wayag lagoon • Narrow core activity space within and around Wayag lagoon • Occasional brief excursions to areas outside of the lagoon up to ~45 km Application of photo ID to identify juvenile manta rays * cartilaginous fish (sharks, rays, and skates) ** best to be assessed using satellite and/or passive acoustic telemetry MAIN findings Manta sightings The estimated body size (disc width) of juveniles ranged from 150 to 240 cm (n = 34). Two juveniles sized 218 and 219 cm were measured using drone. unique IDs 34 47 Newborn and juveniles reef manta rays in Wayag lagoon in 2013–2021 encounters 27 resighting rate (%) 21 longest sighting span Lagoon Backyard Far Inner Lagoon Inner Lagoon Main Lagoon Entrance Front Entrance VR2W acoustic receiver stations Manta nurseries are RARE! It requires massive & long-term effort to identify a nursery area Wayag lagoon is protected within West Waigeo Marine Park A touristic destination with picturesque limestone karst islands Wayag is located the northwest of Raja Ampat archipelago zooplankton Global population decline due to fishing pressure Supported by: Long-term and high residency of juvenile manta rays within Wayag lagoon! months of near-continuous detections 14.5 119 days of consecutive detections 0 detection by receivers outside of Wayag in broa
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Study of vertical abundance stratification of elements in the stellar atmosphere of HD 63401 P. Kashko¹, V. Khalack² ¹Faculty of Physics, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine ²Département de Physique et d’Astronomie, Université de Moncton, Moncton, N.B., Canada E1A 3E9 Abstract Results Chemical abundance References HD63401 is one of the magnetic chemically peculiar (mCP) stars that were recently observed by the space telescope TESS. It may possess a hydro- dynamically stable stellar atmosphere where atomic diffusion in combination with a magnetic field can lead to vertical stratification of elements abundances. The modified ZEEMAN2 code was employed to carry out an abundance analysis of high-resolution and high signal-to-noise spectra obtained for HD63401 with ESPaDOnS. We found that only iron shows clear evidence of vertical abundance stratification in the stellar atmosphere of HD63401. Seven high-resolution spectra were acquired with the spectropolarimeter ESPaDOnS for HD63401. To reduce the obtained data the software package Libre-ESpRIT (Donati et al., 1997) was used. The estimates of the effective temperature and surface gravity are obtained from the best fit of Balmer line profiles observed in Stokes I spectra by the theoretical profiles with the help of FITSB2 code (Napiwotzki et al., 2004). The derived values of Teff=13360 K and log(g)=4.1 were used to calculate a model of the stellar atmosphere employing the code PHOENIX (Hauschildt et al. 1997), which is required to carry out abundance analysis with the help of ZEEMAN2 code (Landstreet, 1988). To select line profiles suitable for analysis we used an automatic procedure developed by Khalack (2018). Fig. 1 presents an example of the FeII 5100A line profile fitted by ZEEMAN2 code. Figure 2. The vertical stratification of iron in the atmosphere of HD63401. The red line is the best line fit derived using Levenberg-Marquardt algorithm Table 1. Average chemical abundance of HD63401 derived from the analysis of ESPaDOnS. We have done spectral analysis of seven available spectra of HD 63401, provided by ESPaDOnS . We derived the averaged chemical abundance of 30 elements. Our estimates are in good accordance with the results published by Bailey et al. (2014), except for Mg, Fe and Pr. Using the Levenberg-Marquardt algorithm fitting algorithm (Marquardt 1963) to the results of analysis of all seven spectra we detected a vertical stratification of iron abundance in stellar atmosphere of HD63401. Bagnulo S., Landstreet J. D., Mason E., et al., 2006, A&A 450 (2), p. 777-791 Bailey J. D., Landstreet J. D., Bagnulo S., 2014, A&A 561, p. A147 Donati J. F., Semel M., Carter B. D., et al., 1997, MNRAS 291, p. 658 Hubrig S., North P., Schöller M., et al., 2006, Astron. Nachr. 327, p. 289-297 Hauschildt P. H., Shore S. N., Schwarz G. J., et al., 1997, ApJ 490, p. 803 Grevesse, N., Scott, P., Asplund, M., et al., 2015, A&A 573, p. A27 Kashko P., Khalack V., Kobzar O., et al., 2020, PTA Proc. 2020, accepted (arXiv:2003.02925) Khalack V., 2018, MNRAS 477, p. 882 Kochukhov O., Bagnulo S., 2006, A&A 450, p. 763 Landstreet J. D., 1988, ApJ 326, p. 967 Marquardt D. W., 1963, SIAM Journal on Applied Mathematics 11, p. 431 Napiwotzki, R., et al., 2004, Astronomical Society of the Pacific Conference Series 318, p. 402–410 Figure 1. The line profile of FeII, fitting by theoretical profile using ZEEMAN2 code We found the phases of spectra using the rotational period P=2.414±0.018 d, derived by Kashko et al. (2020). To check if chemical abundances have vertical stratification in the atmosphere of HD63401 we have fitted the chemical abundance estimates at different optical depths by a line (y = a*x + b) using the Levenberg-Marquardt algorithm (Marquardt, 1963). It uses the method of least squares to find the best fit. We used Python and function curve_fit from library scipy (optimize) for the implementation of the algorithm. To select a significant stratification of chemical abundances throughout all elemen
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The Monotransit Initiative S. ULMER-MOLL 1 , M. LENDL 1 , C. MORDASINI 2 , NGTS team, CORALIE team, TSTPC and WINE contributors 1. Department of Astronomy, University of Geneva, 51 chemin Pegasi, 1290 Sauverny 2. Physikalisches Institut, Universität Bern, Gesellschaftsstrasse 6, 3012 Bern INTRODUCTION Long-period transiting planets provide the opportunity to better understand the formation and evolution of planetary systems. Their atmospheric properties remain largely unaltered by the impact of the host star, and their orbital arrangement reflects a different, and less extreme, migrational history compared to close-in objects. The sample of long-period exoplanets with known radii is still limited, but a growing number of long-period objects reveal themselves through single transits in TESS data. CONCLUSIONS Warm Jupiters have quite long orbital periods compared to Hot- Jupiters but they are still located quite close to their host star. Do these planets form in-situ? Otherwise what are the mechanisms which drive their migration? Such questions are still in debate, thus increasing the sample of warm Jupiters with precise planetary mass and radius is crucial to better understand their formation process. We detected and charaterized four warm giant planets which orbit reasonably bright host stars making these objects valuable targets for follow-up studies of the planetary atmosphere. Summary of the characterized exoplanets: TIC 124029677b: a 20 day period planet with a planetary mass of 3 Jupiter masses and a low eccentricity of about 0.18. TIC 257527578b: a 54 day period planet with a planetary mass around 2.4 Jupiter masses and a high eccentricity of about 0.4 (Ulmer-Moll, in prep) TIC 206541859b, a Saturn mass planet on a 30 day orbit and a low eccentricity (Brahm in prep) TIC 4672985b, a 12 Jupiter masses object with an orbital period of 67 days on a circular orbit. RESULTS METHOD • Vet monotransit events flagged by differents pipelines: TOI, TSTPC, NGTS (Ref 1 & 2) • Select the best candidates • Schedule these candidates for spectroscopic vetting with high-resolution spectrograph CORALIE • Photometric follow up is set up with NGTS in blind survey mode (when single transit is detected) or alias chasing mode (when a set of period aliases can be defined) • Continue radial velocity monitoring once spectroscopic vetting is successful • Optimize observation strategy for candidates revealing significant radial velocity variations • Modeling of the radial velocities to confirm the orbital period of the transiting candidates (Ref 3) • Joint modeling with additional transit events (Ref 4) ACKNOWLEDGEMENTS This work has been carried out within the framework of the NCCR PlanetS supported by the Swiss National Science Foundation. AIM Detect and characterize cool giant transiting planets orbiting bright stars and interpreting their nature using planet formation and evolution models REFERENCES 1. Gill, S., et al. (2020) MNRAS, 491, 1548 2. Montalto, M., et al. (2020) MNRAS, 498, 1726 3. Faria, J. P., et al. (2018) "kima: Exoplanet detection in radial velocities", JOSS, 3, 487 4. Espinoza, N., D. Kossakowski, & R. Brahm (2019) MNRAS, 490, 2262 5. Bayliss, D., et al. (2020) "NGTS - Uncovering New Worlds with Ultra-Precise Photometry", Msngr, 181, 28 Spectroscopic vetting and radial velocity follow-up was performed with CORALIE. This star was also monitored by other spectrographs: FEROS and HARPS. The phase folded transit lightcurves and radial velocity data and corresponding models are shown in the two figures above. A mildy-irradiated but highly eccentric gas giant A single transit event was detected in the TESS Sector 4 data. No second transit was seen in the TESS extended mission, The star was monitored by the Next Generation Transit Survey (Ref 5) in blind survey mode (star is observed every possible night). A second transit was detected by NGTS about two years later after the first one. With an eccentric orbit (e~0.4), this system is rel
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Study of Fe and Fe–based additives upon the sorption properties of the 2LiBH4 + MgH2 ↔2LiH + MgB2 + 4H2 reaction J.A. Puszkiel1,2, F. Karimi1, U. Vainio3, E. Welter3, F.C. Gennari2, P. Arneodo Larochette2, T. Klassen 1, J. Bellosta von Colbe1 and M. Dornheim1 1Institute of Materials Research, Helmholtz–Zentrum Geesthacht, Germany 2Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Centro Atómico Bariloche, Argentina 3HASYLAB at Deutsches Elektronen-Synchrotron, Germany Motivation Results and Discussion Conclusions E-mails julian.puszkiel@hzg.de; jpuszkiel@cab.cnea.gov.ar References [1] A.S. Pedersen, J. Kjoller, B. Larsen, B. Vigeholm, Int. J. Hydrogen Energy, 8 (3), 205, 1983. [2] J.J. Vajo, S.L. Skeith, F. Mertens, J. Phys. Chem. B, 109, 3719, 2005. [3] N. Ohba; K. Miwa; M. Aoki; T. Noritake; S. Towata; Y. Nakamori; S. Orimo; A. Züttel, Phys. ReV. B, 74, 075110, 2006. [4] Ph. Mauron; F. Buchter; O. Friedrichs; A. Remhof; M. Bielmann; C.N. Zwicky; A. Züttel, J. Phys. Chem. B 2008, 112, 906, 2008. [5] P. Debye et al., J. Appl. Phys., 28, 679, 1957. Due to the beneficial catalytic effect of the Fe and Fe-based additives upon the kinetics of MgH2 and their low cost, they were added to the 2LiBH4 + MgH2 reactive hydride composite (RHC) in order to improve the operative condition at which the RHC uptakes/releases hydrogen. Suitable thermodynamic stability ΔH = 40.5 kJ/mol H2 Tdesorption = 225 ºC at 1 bar High capacity 11.45 wt.% H Sorption kinetic constraints - High Tdesorption > 390 ºC - Two steps desorption kinetic XAFS ASAXS VOLUMETRIC MEASUREMENTS + XRD results show that after milling irreversible phases such as LiCl and LiF are formed. + XANES measurements confirm that the oxidation state of Fe after milling is zero, suggesting that Fe, FeB or/and Fe2B can be present in the as-milled materials. + The of Fe is not persistent upon cycling due to the formation of FeB upon desorption and/or large Fe-based nanoparticles with typical lengths of 10 – 17 nm. The correlation lenghts (ξβ) of the Fe rich phase are between 10 – 17 nm. Random two phase model assumption: Debye–Bueche model [5]. The addition of Fe improves the absorption/desorption times during the first cycle. Irreversible phases such as LiF and LiCl are formed during milling. For all the as-milled material, the oxidation state of Fe is zero. After desorption at 400 ºC and 5.5 bar, FeB was clearly detected. XRD ξα ξβ Hydride phase Fe rich phase ) ( ) , ( ) , ( ) , ( q I E q I E q I E q I M M M Fe Fe Fe       C Bq a q a N r q I A e        2 2 2 2 2 3 2 2 ) 1( 8 ) (     / 1 / 1 / 1   a ) 1 /(      a Helmholtz-Zentrum Geesthacht • Max-Planck-Straße 1 • 21502 Geesthacht • Phone +49 (0)4152 87-0 • Fax +49 (0)4152 87-1403 • www.hzg.dehydrogen.hzg.de Acknowledgements 0 1 2 3 4 5 6 FeB Fe2B Fe 2LiH+MgB2+0.1Fe-Iso 2LiH+MgB2+0.1FeCl3 2LiH+MgB2+0.1FeF3 2LiH+MgB2+0.1Fe  (R).k2 R (Å) RHC after Desorption 0.1 Fe 0.1 Fe-Iso 0.1 FeCl3 0.1 FeF3 As-milled 9.0  0.1 nm 12.4  0.1 nm 14.6  0.3 nm 17.1  0.4 nm First absorption 15.1  0.2 nm 10.3  0.1 nm 11.9  0.1 nm 15.4  0.1 nm First desorption 11.9  0.1 nm 12.3  0.2 nm 14.4  0.2 nm 17.6  1.1 nm 0 2 4 6 8 10 Theoretical capacity 2LiH + MgB2  2LiBH4 + MgH2 wt. % H First absorption at 350 ºC and 50 bar 0 5 10 15 20 10 8 6 4 2 0 2LiBH4 + MgH2 2LiH + MgB2 wt. % H Time (h) First desorption at 400 ºC and 5.5 bar 7100 7120 7140 7160 7180 7200 E (eV) Normalized absorption (a.u.) FeB Fe 2LiH+MgB2+0.1Fe-Iso Fe-Iso 2LiH+MgB2+0.1FeCl3 FeCl3 2LiH+MgB2+0.1FeF3 FeF3 2LiH+MgB2+0.1Fe 7112 eV RHC after MM 0 2 4 6 8 10 Time (h) 2LiH+MgB2+0.05FeCl3 2LiH+MgB2+0.025Fe-Iso Theoretical capacity (wt%) wt. % H 2LiH+MgB2 2LiH+MgB2+0.05Fe wt. % H First absorption at 350 ºC and 50 bar 0 1 2 3 4 5 6 7 0 2 4 6 8 10 Second absorption at 350 ºC and 50 bar 10 8 6 4 2 0 Theoretical capacity (wt%) First desorption at 400 ºC and 5.5 bar 0 5 10 15 20 10 8 6 4 2 0 wt. % H wt. % H Time (h) Second desorption at 400 ºC an
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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862357 Integrating crops and livestock: good for the sheep, good for the farmer, good for the soil? Introduction There is increased interest in revisiting the historical practice of grazing winter sown cereals to provide additional grazing during winter and early spring when grass forage is limited. Can integrating grazing livestock and arable farms have also have positive impacts on crop and soil parameters? Such integration may provide a win-win for farmer and environment providing feed and marketable crops as well as reducing synthetic inputs and improving soil health. Trials were carried out at SRUC Craibstone in Aberdeen and several other farms across Scotland testing the effect of grazing intensity on crop yield and soil health. Methods Replicated plot grazing experiments similar to those shown in Figure 1 and Figures 2 & 3. Three replicates of four grazing treatments - ‘no grazing’ and grazing for one, two and three days. Forage biomass and feeding value were assessed every few weeks from November until early May (Table 1). Tillering, disease and weed pressure assessed during the season as well as Visual Evaluation of Soil Structure (VESS) and earthworm counts after harvest. At harvest, plots were combined and measurements of yield, straw yield and 1000 grain weight were taken. Engagement with farmers held throughout the project Conclusion Winter cereals appear very resilient to being grazed - recover well with no significant impact on yield or other agronomic / crop quality - be aware of potential damage to growing points. Evidence of potential legacy effect by increasing earthworm abundance No negative effect to soil structure observed Can be “mob” grazed or more extensively grazed like many of the Network farmers. Evidence of reduced disease levels with potential scope to reduce fungicide sprays on some Network farms. Network farmers reporting reduced seed rates and N fertilizer when grazing their winter cereals Winter cereals have a very good feed value profile Figure 3 – Example of plot design showing grazed and ungrazed plots on the left. On the right is the same site but mid-season showing no visual difference in crop Sheep trampling and poaching may have been expected to have a negative impact on soil structure leading to the grazed crops being trampled into the soil, however, grazing caused no negative impact on soil structure as measure by VESS. Figure 4 – Yield data from three sites across three years for wheat (brown) and barley (beige) Luke Harrold, Niamh Barry, Kairsty Topp, Zach Reilly, David Ross, Christine Watson & Robin Walker Figure 2 – Farmer engagement at Craibstone plots as well as Network Farm Results Despite being grazed to bare soil the crops recovered well and there was no significant difference in yield (Figures 3 & 4) Grazing significantly increased juvenile earthworms abundance at sites which looked at grazed vs ungrazed (p < 0.01) (Fig 5 A-J) Timing of grazing important (Fig 5K) as yield increased from early to late grazing but all were lower than ungrazed at this site. Both early and late grazing improved yield at site L. Figure 5 – Counts of juvenile earthworms at participating farms under different grazing management Figure 1 – Plot layout showing transition area and grazing plots
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Space Weather Monitoring at the Rosse Solar-Terrestrial Observatory Peter Gallagher, Eoin Carley, Pietro Zucca, Joseph McCauley, Diana Morosan, Sean Blake School of Physics, Trinity College Dublin, Ireland Alan Jones, Colin Hogg School of Cosmic Physics, Dublin Institute for Advanced Studies, Ireland ! The Rosse Solar-Terrestrial Observatory (RSTO) was established at Birr Castle in the midlands of Ireland to study solar activity and space weather effects on the Earth's ionosphere and geomagnetic field. A set of solar radio spectrometers based on CALLISTO receivers monitor the Sun at 10-400 MHz, while a magnetometer is used to measure the local geomagnetic field and associated K-index. In addition, the ionosphere is monitored using a sudden ionospheric disturbance instrument. All data are provided in near-realtime at www.rosseobservatory.ie. X-rays associated with solar flares can disturb the Earth’s ionosphere and interrupt radio-based communications systems across the day side of the Earth. The RSTO sudden ionospheric disturbance instrument is used to m o n i t o r v e r y l o w frequency (VLF) signals. The ionosphere reacts rapidly to radiation from solar flares and can take hours to recover. Solar radio bursts can cause interruptions in communications systems on Earth. At RSTO, solar radio bursts are monitored using CALLISTO spectrometers at 10-400 MHz (Zucca et al, Solar Physics, 2012). ! A bicone and a LOFAR Low Band Antenna array observe the Sun at 10-100 MHz while a log-periodic operates at 100-400 MHz. The frequency band is covered by 1,800 channels, sampling at 250 ms per sweep. ! The system is optimised to measure dynamic spectra of Type II radio bursts produced by coronal shocks, and Type III radio bursts produced by near-relativistic electrons streaming along open magnetic field lines. ! Solar Radio Bursts Ionospheric Distrubances The Future of RSTO RSTO is part of an international effort to study the physics of space weather, and monitor the effects of the Sun on the Earth. We are now exploring joining a number of networks, such as LOFAR and SuperDARN, which w o u l d e n a b l e u s t o m o r e accurately monitor the causes and consequences of space weather. I-LOFAR www.lofar.ie Geomagnetic Storms Geomagnetic storms can be produced by the coronal mass ejections and changes in the interplanetary magnetic field. ! A magnetometer at RSTO measures the geomagnetic field which is used to derive a local K-index in near-realtime.
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Abstract M. Tsantaki1, D. Andreasen2 1Osservatorio Astrofisico di Arcetri – INAF, 2Instituto de Astrofísica e Ciências do Espaço Methodology We knowledge the funding from MIUR Premiale 2016: MITIC The synthetic spectra are created on-the-fly and are convolved with: 1) macroturbulence, 2) projected rotational velocity, 3) instrumental broadening to match the observations. Models atmospheres: Kurucz (Kurucz 1993) & MARCS models (Gustafsson et al 2008). Line lists: Tsantaki et al. (2018) for stellar parameters and Adibekyan et al. (2015) and Delgado Mena et al. (2015) for the chemical abundances. Spectral manipulation: local normalization and filters for cosmic rays The line list Li abundances The atomic data of the line list is calibrated based on the Solar & Arcturus Atlases. Comparison of synthetic spectrum with VALD3 data (green line), synthetic spectrum after the calibration of the atomic data (red line) and the Atlases (black line) (see Tsantaki et al. 2018). An example of the fit of the lithium line for a giant star from our recent work on Li abundances in open clusters. The synthetic fit is in green and the observations in black. Acknowledgements References Resutls FASMA has been used in the following works: - characterization of planet hosts for the Ariel mission Brucalassi et al. 2021 - characterization of high and medium resolution samples Tsantaki et al. 2018 - derivation of Li abundances for giant stars in open clusters (Tsantaki et al. 2021 in prep.) FASMA: a package for stellar parameters and chemical abundances Code description: Tsantaki et al. 2020 https://github.com/MariaTsantaki/FASMA-synthesis Science validation: Tsantaki et al. 2018 FASMA delivers the atmospheric stellar parameters: effective temperature, surface gravity, metallicity, microturbulence, macroturbulence, and rotational velocity based on the spectral synthesis technique. The principle of the technique relies on the comparison of synthetic spectra with observations to yield the best- fit parameters under a χ2 minimization. FASMA also delivers chemical abundances of 13 elements (Li, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, and Ni). The python code is wrapped around the spectral synthesis package: MOOG version 2019 (Sneden et al. 1973) in a very user-friendly way.
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Variable Star Science with Community Brokers: Overview and goals Nina Hernitschek (CITEVA, Universidad de Antofagasta; Rubin LSST Transients and Variable Stars Science Collaboration) Community Alert Brokers How LSST can help Variable Stars software systems to provide, characterize and classify big data to enable science change in luminosity few parts per million factor 1000 temporal baseline seconds centuries signal shape periodic aperiodic/ random Periodic Variable Stars: RR Lyrae, Cepheids ►measure apparent mean brightness m ►measure period P ►using period-luminosity relation, get absolute brightness M ►solve distance modulus equation: log d [parsec]= (m−M+5) /5 period (days) absolute magnitude -7 -6 -5 -4 -3 -2 -1 0 1 0.3 1 3 10 30 100 RR Lyrae Type II Cepheids Type I (classical) Cepheids Rubin Observatory's real-time difference image analysis will produce a world-public stream of alerts which will be distributed to community brokers. The Importance of Long-Time Monitoring accurate, up-to-date information (and not from data taken years ago) necessary to dynamically characterize substructure in the outer Galactic halo periodic variable stars allow for distance calculation: Their period is directly related to their true brightness. variability important for velocity calculation: vobs = vsystemic + vphotospheric from pulsation models: observe at φ = 0.37 where vphotospheric ∼0 crucial: accurate light curve information What are variable stars? A star is a variable star if we can measure its brightness changing over time. Variable stars differ regarding how those brightness changes are caused by events inside, on the surface of, or around that star. Why are variable stars important? variations provide unique information about the nature and evolution of stars and the galaxies that host them and our universe in general period-amplitude modulations (Blazhko effect) must be taken into account to correctly determine distances and velocities allow us for creating 3D maps of structures in our Milky Way typical use cases from complex data: ►immediate follow-up (e.g.: supernova, multi-messenger astronomy) ►“unknown unknowns” ►known rare “1-in-a-million” events possible with LSST: large footprint high cadence depth 10 years + ´+ + ´ LSST: ~400 kpc PS1 3π: ~120 kpc 10 kpc limit of SDSS studies for kinematics and [Fe/H] Point of Interest Broker (POI) The idea: An alert broker to enable users to get updates on variable star observations within interesting regions. predefined stellar streams, dwarf galaxies and globular clusters (frequently updated) user-defined The Implementation POI is a downstream broker of ANTARES. ►store feature history ►more specific classification ►amplitude-period-phase modulation (Blazhko effect) ►watch for modulation ►specific “Points of Interest” ►specific calculations for follow-up: phase/time from model
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The work involves the use of optical resonating cavity used for light analyte interaction which is based on a coupled ring resonator geometery. The procedure is to sense the presence of a chemical and to covert the presence of chemical/biochemical analyte into a measurable optical signal. Introduction • Optical sensors fundamentally require interaction between light and target molecules. • Increased interaction result in increased sensitivity. • In a waveguide or optical sensor light interacts with target molecule only once. In a resonator, light circulates in resonator multiple times. • Ring resonators finds application as a chemical sensor for variety of applications like biochemical assays, sample preparation, genomics ,drug development and investigation, food safety and environmental monitoring. • Various chemical sensors based on ring resonating cavity had different operational geometries solely dependent on the fabrication method. Simulation • Parameters considered in simulation : Waveguide width, height, thickness, radius and coupling length to be constant. • Coupling Gap is variable. • Top clad changed from a solution to water (optimization analysis). • Method : Wavelength Scanning. • 50000 test points. • Results discussed : resonance spectrum, mainly drop port. • Optimized Geometry. Results Experimental Setup Remarks • Light Source : Collimation, Beam width and Spot Size • Test Setup : Detection, Microscope, 3 dimensional motion controllers, Spectrometer, power meter, microscope. • The detection methodology is to detect the resonance wavelength which can be identified by intensity measurement at resonant wavelength picked up at drop port. Optical Characterization Of A Polymer Ring- Resonator Used For Environmental Monitoring Of Chemical Pollutants Zain Hayat, Farida Meziane, Simon Joly, Vincent Raimbault, Laurent Bechou Laboratory Material Integration System (IMS) University of Bordeaux France
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The Stellar and Observational Properties of the TESS Prime Mission 2-min Targets Joshua Pepper1, Thomas Barclay2,3, Luke G. Bouma4, Christopher J. Burke5, Michael Fausnaugh5, B. Scott Gaudi6, Ryan J. Oelkers7,8, Keivan G. Stassun8,9, Joshua N. Winn4 1 Lehigh University, 2 NASA Goddard Space Flight Center, 3 University of Maryland, Baltimore County, 4 Princeton University, 5 Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, 6 The Ohio State University, 7 Texas A&M University, 8 Vanderbilt University, 9 Fisk University See upcoming paper from Fausnaugh, et al. The K-dwarf valley Photometric precision across the main sequence TESS Observing Duration Properties for all Targets 153,000 stars observed for one sector 9,000 stars observed for >260d, but only 3,900 observed continuously References: • Stassun, et al. 2018 “The TESS Input Catalog and Candidate Target List“ AJ, 156, 102 • Stassun, et al. 2019 “The Revised TESS Input Catalog and Candidate Target List“ AJ, 158, 138 Figure 3: Since photometric precision is generally a monotonic function of apparent brightness, early-type stars being more luminous have more precise light curves. Although the TESS target selection process prioritized smaller stars at a given apparent brightness, late-type dwarfs are substantially fainter, yielding light curves with lower precision. Figure 2: Stars are prioritized for transit observations according to their sensitivity to the smallest detectable transits. That depends on their brightness and size. F and G dwarfs dominate that set due to their brightness, while M dwarfs are also included due to their small size. Once the closest F and G dwarfs are included, M dwarfs (being more common) occupy the next batch of targets. K dwarfs suffer in this metric due to being too faint for good photometric precision compared to F and G dwarfs, but too big to yield deep transits compared to M dwarfs. Figure 1: TESS observed 232,705 stars with 2-min cadence in the prime mission. The stars were selected for a number of science purposes, with the largest batch coming from the exoCTL, which prioritized stars based on their suitability for small planet transit detection and the length of time TESS observes them. Stars closer to the continuous viewing zones thus have higher priority. But the mission requires a certain number of target stars in each camera and CCD. Therefore the stars observed at mid-latitudes have different population characteristics than those at high latitudes, as shown in Fig 2 above. Figure 4: Most stars (abut 153,000 out of 233,000) were observed for just a single sector in the prime mission. But just because a star is in or near the continuous viewing zone, they are not necessarily observed during every sector, due to gaps between cameras or detectors. Only 3,900 stars were observed in 13 consecutive sectors. All data described in this poster will be distributed as machine- readable tables in an upcoming paper.
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OPeNDAP’s Server4 Building a High Performance Data Server for the DAP Using Existing Software Software Reuse The essential f eatures of Serv er4 are: Two process design can be adapted to a v ariety of dif f erent conf igurations The serv er supports sev eral dif f erent application protocols f or dif f erent ty pes of inf ormation Formal communication between the processes (to be published soon) will enable other groups to write their own f ront-ends In 1993 the Univ ersity of Rhode Island began a NASA-f unded ef f ort to dev elop a data sy stem f or ocean data that would take adv antage of the Internet. Out of that ef f ort, the Data Access Protocol, a serv er implementing the protocol and sev eral compatible client applications were dev eloped. The data serv er was based on the Common Gateway Interf ace (CGI) used f or many web-based interf aces, largely because of the simplicity of those ty pes of sy stems. As the use of the serv er spread, its limitations became more apparent. At the same time, other issues with the data sy stem became apparent and new work was started to address those issues (such as metadata non- unif ormity , searching dif f iculty and collection organization). Serv er4 is one aspect of that work. Its goals are to make it easier to solv e these problems and to reuse as much of our (and others’) existing DAP-compliant sof tware as possible. Sof tware reuse is an important part of the Serv er4 ef f ort. Since the start of work on the DAP, signif icant ef f ort has been made dev eloping DAP-compliant serv er sof tware (client sof tware too, although that is not the f ocus of this poster) and to make a new serv er we needed to use as much of that work (and knowledge) as possible. In the OLFS, the THREDDS implementation is 100% f rom the Unidata THREDDS library . Other elements were written new f or this project. In the BES, the f ramework itself is an extended v ersion of the Earth Sy stem Grid II data serv er dev eloped by NCAR/ESSL/HAO. It represents about 70% reuse. The BES Format Modules are about 5% new sof tware with the remaining 95% reused f rom the Serv er3 ‘Data Handlers’ (in f act the source code distributions f or the f ormat modules still build the Serv er data handlers too). The PPT modules used by both the BES and OLFS are inherited f rom the ESG II project OLFS Java Servlet Engine BES Unix Daemon BES Commands XML- encapsulated object Data files, Database, … DAP2 THREDDS HTML Optional THREDDS catalogs Server4 Supports several protocols and a high level of reuse using a two process architecture
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Prof. Dr. techn. Günter Scheffknecht Institute of Combustion and Power Plant Technology (IFK) Pfaffenwaldring 23, 70569 Stuttgart, Germany www.ifk.uni-stuttgart.de Study area With 12.7 million passengers (2019) and around 400 flights per day, Stuttgart airport is the 6th largest airport in Germany. The investigations were carried out in three phases in 2020. The measuring locations were on both sides of the airport, at different distances in a direct extension of the runway. The results presented here focus on locations west of the runway at 1 km (Point 2) and 2 km (Point 1) from the start of the runway. The planes were approaching from the west with easterly winds. In addition, measurements were carried out on a bridge over the busy federal highway B27. Contribution of Airplane Engine Emissions on the Local Air Quality around Stuttgart Airport during and after COVID-19 Lockdown Measures Aim of the study Previous airport studies conducted in Los Angeles, Amsterdam and other cities have shown that aircraft can significantly increase air pollutant concentrations around the airport and can be measured even at distances of several kilometers. Since the results cannot be directly transferred from one city to another and no comparable measurements were carried out at Stuttgart airport, the aim of the study was to investigate whether increased air pollution levels can be measured at the airport fence and in the immediate vicinity of the airport in Stuttgart. Since there are busy roads in the immediate vicinity of the airport (e.g. A8, B27), it should also be investigated whether the exhaust gas plumes from road traffic and air traffic can be distinguished. Methodology The vehicle platform, a Renault Twizy, was equipped with the following measurement technology. The runway at Stuttgart airport was renovated at the beginning of the COVID-19 pandemic in April 2020. The airport was therefore closed (Measurement phase I - mid April 2020). The airport was then reopened but due to the COVID-19 lockdown measures, very few flights took place (Measurement phase II - early to mid June 2022). More flights took place during the 2020 summer holidays, but still the number of flights were around 50% fewer than before the COVID-19 pandemic (Measurement phase III - mid August to mid September 2020). Conclusions Landing planes produced increased concentrations of very fine particles. The mean diameter of the measured particles drops to very low values of 10 to 20 nm. Peaks were easily measurable even at a distance of 2 km. Road traffic emissions also produced UFP, but with slightly larger diameters. Hence, UFP can be distinguished from road and air traffic. Outlook Mobile measurements should be carried out in adjacent residential areas, also at a greater distance from the airport. Mobile measurements in combination with long-term measurements should provide information about the exposure of the population to high pollutant concentrations in the vicinity of the airport. More information regarding this research can be found in the following publication: Samad, A.; Arango, K.; Chourdakis, I.; Vogt, U. Contribution of Airplane Engine Emissions on the Local Air Quality Around Stuttgart Airport During and After COVID-19 Lockdown Measures. Atmosphere 2022, 13, 2062. DOI: https://doi.org/10.3390/atmos13122062 Contact: M.Sc. Abdul Samad – abdul.samad@ifk.uni-stuttgart.de Department of Flue Gas Cleaning and Air Quality Control (RuL) Results Measurement phase I - no air traffic: The PNC concentrations were at a low level with values < 10,000 particles/cm³, the mean particle diameter Dp at > 40 nm. Measurement phase II – less air traffic: Individual peaks from landing aircraft could be recorded. PNC concentrations were > 10,000 particles/cm³ at recorded aircraft peaks. Measurement phase III – substantial air traffic: Many UFP peaks from landing aircraft could be recorded. They generated PNC peaks of up to 300,000 particles/cm³. During the PNC peaks, the average pa
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PRESERVING DATA TREASURES Akansha Rawat, Dr. Dr. Jörg Hoffmann, Dr. Tanja Rottstock Institute for Strategies and Technology Assessment, Julius Kühn Institut Role of JKI Provides data for long term research in the field of plant cultivation, genetics, soil science, plant breeding and protection. German long term field trials on JKI experimental stations. On farm investigations of cultivated plants, useful insects, animal and bird species. Our Objective We aim to secure existing data from a completed project. In a long-term study over a period of 30 years, agricultural use and biodiversity in arable landscapes were recorded and analysed. Recommendations for agriculture, nature conservation and biodiversity monitoring were derived from this. Reference: Hoffmann, J. (2023). Biodiversität im Zeitvergleich. Strukturelemente und Nutzungen räumlich identischer Ackerbaugebiete 1991-1993 und 2018-2021. Auswirkungen auf die Biodiversität. Berichte aus dem Julius Kühn-Institut 224: 940 S. We plan to ensure the visibility, accessibility and future use of the long term biodiversity data sets of e.g. plants, insects, and bird species in agricultural landscapes. Establishing the workflow For our use case, we establish a workflow using the comprehensive, existing data on landscape structures, flora, cultivated plants, birds and butterfly species from BioZeit (1991-1993, 2018-2021): Biodiversität im Zeitvergleich (Hoffmann 2023) and harmonize the structure of datasets according to the FAIR data principles accompanied with a richly described metadata based on ABCD metadata schema. To effectively manage the data, an instance of BEXIS2 software has been set up at JKI. This step will provide a good basis for standardizing, reusing and integrating the datasets. Using the available data in BioZeit new refined data structures will be developed along with the metadata which will be migrated to BEXIS2 as a starting point towards the long term archiving of this data. Overall Aim In order to ensure the use of valuable, comprehensive data sets, we plan to publish and archive the data through relevant repositories (for eg., GBIF, Pangaea), ensuring its preservation, visibility and availability for current and future research. We welcome your suggestions and collaboration: Akansha.Rawat@julius-kuehn.de Source: Dahnsdorf Experimental Station, JKI archive Source: Icons https://www.carbondesignsystem.co m/guidelines/icons/library/ Source:BEXIS2,Uni Jena, https://bexis2.uni-jena.de Scan the code to know more about the project BioZeit
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Design Image Interactive resource Other Sound Musical Notation resource types Practice made Practical. Reducing the OTHER of non-text Adam Vials Moore (Jisc), Jenny Evans (University of Westminster), Rachael Kotarski (British Library), Taylor Mudd (Cayuse) Discoverability Landscape: Where does non-text / practice research fit? ‘other’ or select the ‘best fit’ Persistent Identifiers Metadata standards Discoverability Practice Research • cross disciplinary • documents process • PRAG-UK report recommends a project item type Non-text outputs as such needs a community of practice to agree on what the form is so that this can be mapped to the discoverability landscape • intersectional - crosses multiple communities and goes beyond universities - is relevant to galleries, libraries, museums and archives • may have multilple pages, files, permissions, rights, contextual images, access levels, may be dynamic Harvests PDF only, uses rioxx, OpenAIRE Indexes text only, PDFs less than 5MG, one file per article Search Engine Optimisation (SEO) mobile optimised design, semantic mark-up, include keywords in item URL, canonical links Disciplines that share research with primarily non-textual outputs do not benefit from a scholarly communications landscape that is focussed on the discovery, access and inquiry of STEM textual articles and data. Bringing together experts into a community of practice, such as repositories that have built taxonomies to address non-text outputs, we propose building on the persistent identifier and metadata vocabularies that underpin global infrastructure. Enabling richer, more descriptive work types, allowing better discoverability, and bringing a future where all research is equally valued. Audiovisual Collection Event Image InteractiveResource Model PhysicalObject Sound Other ResourceTypes Other Project item type recommended by Bulley-Salin Other also used by CRediT - Contributer Roles Taxonomy
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‘Storyboarding’ in the classroom Malizukiswe V. Vacu1, Craig Ehrenreich1, Nelisiwe Chonco1, Grace Aguti2, Xiangcong A. Luo3, Bianke Loedolff1† 1Faculty of AgriSciences, Stellenbosch University; 2Earth University; 3Faculty of Arts & Social Sciences, Stellenbosch University Professional Educational Development of Academics (PREDAC) 2019 vs. https://www.storyboardthat.com/https://wordsearchlabs.com/view/108017 1 2 3 4 5 Storyboarding es una herramienta visual de aprendizaje, cooperativa y narrativa que podría beneficiar a los alumnos de todas las disciplinas en las estructuras educativas. Esta pantalla visual permite a los alumnos ver las interrelaciones entre los conceptos centrales descritos en un marco de módulos. Tanto el experto como los alumnos participan en este proceso de Storyboarding a través de una discusión continua en el aula. Los conceptos e ideas se muestran en forma visual clara en un storyboard y por lo general, pueden incluir (i) una revisión del tema e introducción a conceptos avanzados dentro del tema, (ii) objetivos de aprendizaje, (iii) tiempo de preparación dentro y fuera de la clase para estudiantes, (iv) limitaciones de aprendizaje y (v) comprensión de contenido de aprendizaje complejo. Luego, los alumnos tienen el desafío inverso de encontrar conceptos básicos dentro de un rompecabezas de palabras, identificar los vínculos entre las palabras y desarrollar una pregunta desafiante dentro de su contexto. Storyboarding en clase presenta a los alumnos la oportunidad de desarrollar habilidades de pensamiento crítico, creativo y proporciona una plataforma de aprendizaje interactiva para aplicar y contextualizar los objetivos de aprendizaje. †Correspondence: bianke@sun.ac.za
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Abstract Low-light image enhancement has been very popular for improving the visual quality of image representations, while low-light images often require advanced techniques to improve the perception of information for a human viewer. One of the main objectives in increasing the lighting conditions is to retain patterns, texture, and style with minimal deviations from the considered image. To this direction, we propose a low-light image enhancement method with Haar wavelet-based pooling to preserve texture regions and increase their quality Low-light image enhancement based on U-Net and Haar wavelet Elissavet Batziou1,2, Konstantinos Ioannidis1, Ioannis Patras2, Stefanos Vrochidis1, Ioannis Kompatsiaris1 1Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece {batziou.el,kioannid,stefanos,ikom}@iti.gr 2School of Electronic Engineering and Computer Science, Queen Mary University of London, Mile End Road London E1 4NS {e.batziou,ipatras}@qmul.ac.uk Introduction Image acquisition in low-lighting conditions is challenging to be improved when low brightness, low contrast, a narrow gray range, color distortion and severe noise exists, and no other sensor is involved as for example multiple cameras of different specifications. Challenges: • maximize the information involved from the input image on the available patterns • extract the colour information that is hidden behind the low values of luminance. Contribution of our work: • Photorealistic style transfer for under-exposed image enhancement. Feature aggregation combines features of different scales to reach an improved image reconstruction through photorealistic style transfer to achieve a natural stylization effect. • A modified U-Net based architecture is proposed that involves dense blocks and wavelet pooling layers. • Encoding using low frequency (LL) component and unpooling using high frequency components (LH, HL, HH). Haar wavelet decomposes the original signal into channels that capture different components, which leads to better image enhancement. Methodology A modified U-Net-based network is combined with wavelet transformations and Adaptive Instance Normalization (AdaIN). The proposed network is comprised by the following three sub-components: encoder, enhancer and decoder. Results (cont.) Conclusion and Future work • A photorealistic style transfer approach is adapted and modified to low-light image enhancement. • The method is based on a U-net architecture using dense blocks and three main modules, namely encoder, enhancer and decoder. • The encoder and enhancer include a Haar wavelet based pooling layer. • Experiments in two datasets compared the proposed method with recent works in image enhancement, showing that the proposed approach achieves SoA with less computational resources in training and testing processes. • Future modifications will focus on evaluating further the impact of the wavelet incorporation and their deployment in other levels of the architecture. Acknowledgements This work was partially supported by the European Commission under contracts H2020-952133 xR4DRAMA and H2020-958161 ASHVIN. Decoder: mirrors the encoder structure (yellow box) with four upsampling blocks. Each block consists of: • an upsampling layer • three convolutional layers • a concatenation operation that receives the corresponding encoder feature coming from the enhancer module. Enhancer: passes multi-scale features from the encoder to the decoder (purple box). Feature aggregation allows the network to incorporate spatial information from various scales and keep the detailed information of the input image. Encoder: has convolutional layers and downsampling dense blocks (blue box). Downsampling dense blocks contain: • a Haar wavelet-based pooling layer • a dense block (three densely connected conv. layers) • two convolutional layers Datasets LOL dataset has 500 image pairs: • 485 pairs randomly selected for training • 15 pairs for testi
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Boys and girls in the Bronze Age Europe: burial practices at the Mokrin necropolis (2100-1800 BC) Marija Krečković Gavrilović1, Mina Amzirkov1, Marko Porčić1, Katharina Rebay-Salisbury2, Fabian Kanz3, Michel Wolf4, Lidija Milašinović5 & Sofija Stefanović1 1 Laboratory of Bioarchaeology, Department of Archaeology, Faculty of Philosophy, University of Belgrade, Serbia 2 Department of Prehistoric and Historical Archaeology, University of Vienna, Austria and Austrian Archaeological Institute, Austrian Academy of Sciences, Vienna, Austria 3 Unit of Forensic Anthropology, Medical University of Vienna, Austria 4 Department of Analytical Chemistry, University of Vienna, Austria 5 National Museum Kikinda, Serbia Introduction Methods & Materials Fig. 1 – Location of the Maros culture necropolis Mokrin (2100 – 1800 BC), situated in Northern Serbia *Corresponding author: Marija Krečković Gavrilović marija.kreckovic@f.bg.ac.rs | Laboratory for Bioarchaeology | Department of Archaeology | Faculty of Philosophy | University of Belgrade Since the presence of animal bones in graves seems to represent a different dimension of variability, which is not related to sex, we decided to repeat the analysis excluding animal bones as a type of grave goods. This left us with a sample of 154 individuals (86 women and 68 men). In the repeated correspondence analysis, the first two dimensions explain 32% of the total variance. The Axis 1 (18% of total inertia) is the one separating the graves by sex (Fig. 3). In both Fig. 2 and Fig. 3 it is evident that some grave goods (like bone and metal needles, hair rings and bracelets) are almost exclusively found in the graves of women. For the subadult individuals, the first two dimensions of the correspondence analysis explain 39% of the total variance (Fig. 4), with Axis 2 (17.1% of total inertia) differentiating types of grave goods by sex. The only grave goods that seem to be specific to burials of girls, are bone needles and necklaces. As with adults, there are some weak statistically significant differences in types of grave goods, but other variables should be considered alongside sex/gender. For the adult individuals, the first two dimensions of the correspondence analysis explain 33% of the total variance (Fig. 2). Interestingly, Axis 1 is separating those graves that had animal bones from all the rest, while Axis 2 differentiates graves by sex. On the other hand, grave goods marked as typically male (like weapons), are found more often in the graves of women, than typically female grave goods are to be found in male burials. Results & Discussion Fig. 5 Grave 287 from Mokrin necropolis. Burial of an adult women in typical courched position, oriented South-North, on her left side. Photo documentation courtesy of National museum in Kikinda This research was supported by the Science Fund of the Republic of Serbia, Grant #6683 INFANO Girls and Boys in the Bronze Age Europe: Influence of biological sex on health, growth, nutrition and social position 2100-1500 BC. Conclusion References Buikstra, Jane E., and Douglas H. Ubelaker. 1994. Standards for Data Collection from Human Skeletal Remains. Arkansas Archeological Survey Research Series, no. 44. Fayetteville, AR: Arkansas Archeological Survey. Stewart, Nicolas Andre, Raquel Fernanda Gerlach, Rebecca L. Gowland, Kurt J. Gron, and Janet Montgomery. 2017. Sex determination of human remains from peptides in tooth enamel. Proceedings of the National Academy of Sciences, 114: 13649–54. https://doi.org/10.1073/pnas. Žegarac, et. Al. 2021. "Ancient Genomes Provide Insights into Family Structure and the Heredity of Social Status in the Early Bronze Age of Southeastern Europe." Scientific Reports 11 (1). Research on the role of children in prehistoric societies, particularly concerning the impact of biological sex on their growth, development, and social status, is limited. This gap hampers our understanding of intersectionality between sex, gender, kinship and social s
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Evaluation of developmental toxicity, immunotoxicity and Endocrine Disruption Caused by Exposure to Triazines, Triazoles and Short-Chain PFAS Triazole fungicides, triazines and short-chain PFAS are generally persistent and mobile (PM) chemicals. Their high water solubility and slow degradation makes them particularly likely to pollute potable water, leading to potentially high degrees of exposure in humans. To gain more insight in the hazards of these compounds, 16 triazoles, 9 triazines and 10 PFAS were tested for developmental toxicity on wild type zebrafish (Danio rerio) embryos and for endocrine disruption on cell lines. We are still working on two immunotoxicity assays to show effects of chemical exposure on bacterial clearance and phagocyte migration in zebrafish embryos. The developmental toxicity was measured using a growth scoring system [1]. The zebrafish embryos were also checked on teratogenicity and heart rate. Benchmark doses (BMD5) for a 5% decreased response were calculated to compare the potency of the tested chemicals. The endocrine disruption was tested with reporter gene cell lines regarding hormone receptor agonism and antagonism. Also, effects on steroidogenesis were tested using a human adrenocortical (H295R) cell line and liquid chromatography tandem mass spectrometry on the supernatants Peter Cenijn Vrije Universiteit Amsterdam Majorie van Duursen Vrije Universiteit Amsterdam Wilbert Bitter Vrije Universiteit Amsterdam Introduction and methods • Nine of the tested triazole fungicides showed activity on zebrafish embryo growth and heartbeat (table 1). Four of these remain to be tested in dilution series. • The underlying mechanism has been described earlier as the inhibition of Cytochrome P450 (CYP) 26 that regulates the catabolism of retinoic acid which is an important signaling molecule during embryogenesis and cardiogenesis [2]. • These same triazole fungicides showed effects on steroid hormone synthesis (figure 2). The steroidogenic profile after exposure of most triazoles shows an increase of progesterone and 17aOH progesterone and decrease of all other steroids. This is caused by inhibition of CYP 17 and CYP 21 which prevents the transformation of these progestogens to the other hormones further down the steroidogenic cascade. • In addition to inhibiting CYP enzymes, the triazole fungicides also show antagonism towards the estrogen (ER) and androgen receptor (AR). This means that exposure to these chemicals have multiple mechanisms to exert endocrine disruption. This antagonistic activity may in turn lead to decreased expression of CYP enzymes. • In conclusion, possible pollution of potable water by triazole fungicides is a cause of concern due to their potential of endocrine disruption and embryotoxicity. Results, conclusion and discussion This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101036756. Maxim Carlier m.p.carlier@vu.nl Vrije Universiteit Amsterdam Partners Timo Hamers Vrije Universiteit Amsterdam growth score Heartbeat ametryn BMD5: 9.815 μM no effect bitertanol BMD5: 8.811 μM BMD5: 2.802 μM fenbuconazole BMD5: 14.15 μM BMD5: 4.623 μM tebuconazole BMD5: 17.26 μM BMD5: 9.448 μM propiconazole BMD5: 13.4 μM BMD5: 2.989 μM triadimenol no effect BMD5: 5.788 μM tetraconazole to be tested to be tested cyproconazole to be tested to be tested difenoconazole to be tested to be tested paclobutrazol to be tested to be tested Table 1: BMDs for the growth scores and change in heartbeat of embryos exposed to active compounds. Prior to these dose response experiments, all 36 chemicals were tested at 100 μM. Compounds that showed toxicity were tested in serial dilutions. References: [1] Hermsen, S. A., van den Brandhof, E. J., van der Ven, L. T., & Piersma, A. H. (2011). Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. Toxicology
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NATIONAL RESEARCH DATA INFRASTRUCTURE FOR ENGINEERING SCIENCES100011101011000111010110001110101Finding & applying requirementsKnowing & choosing the right toolLearning & starting RDMAnd others...Automate your RDM!RDM is complex!Get support!Jarves, do my RDM!Your Journey starts here!JarvesThe Joint Assistant for Research in Versatile Engineering SciencesJarvessupportsresearchersoftheengineeringsciencesintheireverydaywork.ItfocusesonthereductionofeffortandtimeofRDM.Thisisachievedbyaddressingthefollowingpoints:GuidanceinRDMByorderingtheRDMac-tivitiesbasedontheiroccur-renceintheengineeringresearchprocess,JarvesprovidesastructureforRDMinengineering.DecisionSupportBasedontheresearch’sgeneralenvironment,likerequirementsoffundingorganisationsorinstitutionalboundaries,Jarvesprovidesinformationonthenextstepsandavailabletools.ConnectingbeyondAsJarvesisbasedonthePythonDjangoRESTFrame-work,itoffersabroadcon-nectivitytootherservices,allowingforseamless(meta-)dataexchange.The authors would like to thank the Federal Government and the Heads of Government of the Länder, as well as the Joint Science Conference (GWK), for their funding and support within the framework of the NFDI4Ing consortium. Funded by the German Research Foundation (DFG) -project number 442146713.Meet the digital RDM assistant.Your funding:Your university:Your institution:Your discipline: Production TechnologyGenerate RDMGet Training ➢Overview: Research Data Management ↗ ➢Overview: Data life cycle (DLC) ↗ ➢How to: DMPs ↗ ➢Versioning Source Code –A Git Tutorial ↗ ➢Software Develop-ment: PyPi ↗ ➢…1000111010110001110101Tobias Hamann and Jonas Werheidt.hamann@wzl-mq.rwth-aachen.de WZL | RWTH Aachen University Chair of Production Metrology and Quality Management & Institute for Information Management in Mechanical Engineering (Prof. Robert Schmitt) Metadata4IngWhere to start?Where to find information?What to learn? The… Data collections explorerDMP tool:Code Repository:Access solution:…Your Input
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Reference collection for regulated viruses and viroids (VIRUSCOLLECT) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 300,000 Picture 1 Picture 1 Picture 1 Goals The goal of VIRUSCOLLECT is to establish a common plant viruses and viroids collection by linking collections of individual institutes via Q- bank and to make collection and reference materials publicly available for phytosanitary research and diagnostic laboratories. Research consortium AT-AGES, DE-JKI, NL-NPPO-NL (EZ) and UK- SASA Contact information Project coordinator: Annelien Roenhorst j.w.roenhorst@nvwa.nl Key outputs and results Accessibility of plant viruses and viroids of phytosanitary concern via Q-bank, which provides data on characteristics, i.e. biology, serology and sequences, and information on availability of isolates. Objectives • To define and implement quality standards for Q-bank linked collections (characterisation, maintenance and provision of isolates and reference material) • To collect and characterise isolates of selected regulated viruses and viroids and make both data and isolates available via Q-bank, i.e. viruses of cereals, potato, stone and pome fruits, whitefly-transmitted viruses, Tospoviruses 11/2013-10/2015
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Cécile Pohar𝟏,𝟐, Yousr Rekik𝟏, Benoit Gallet𝟑, Emmanuelle Tillet𝟒, Agnès Castan𝟒, Mireille Chevallet𝟏, Nicola Vigano𝟐, Pierre−Henri Jouneau𝟐, Aurélien Deniaud𝟏 1 Univ. Grenoble Alpes – CEA – CNRS, Laboratoire de Chimie et Biologie des Métaux, Grenoble, France; 2 Univ. Grenoble Alpes, CEA, IRIG, Laboratoire Modélisation et Exploration des Matériaux, 38000 Grenoble, France; 3Institut de Biologie Structurale, CEA, CNRS, Univ. Grenoble Alpes, 71 avenue des Martyrs, F-38042 Grenoble, France; 4 Univ. Grenoble Alpes - CEA – CNRS, Laboratoire de Biologie du Cancer et de l’Infection, Grenoble, France 1 Liver Architecture : Structural unit : hepatic lobule formed by hepatocyte cords Sinusoids : fine capillaries connecting the hepatic artery and portal vein to the central vein LSEC : complex structure, wide regions + thin regions with fenestrae LSEC fenestration : bidirectional flow of small molecules like an ultrafiltration system. Figure 1 : Liver architecture 3D electron microscopy (3D-EM) enables to obtain the ultrastructure of biological samples. Liver Sinusoidal Endothelial Cell fenestration (LSEC) forms an interface that allows the transport of essential molecules between blood and hepatocytes. LSEC fenestration can be characterised by Focused Ion Beam - Scanning Electron Microscope (FIB-SEM) at nanometer resolution. Analysing how Bone Morphogenetic Protein 9 (BMP9) affects the structure of LSEC is essential to understand the role of BMP9. Context and Objectives : Analysis of Liver Sinusoidal Endothelial Cell fenestration from 3D electron microscopy data Contact : cecile.pohar@cea.fr / cecile.pohar@gmail.com Methods : 2 • Minimum voxel size ~ 3 x 3 x 3 nm𝟑 • Thickness of a FIB slice down to 3 nm • Area selected : tens of microns Results : 3 3D Electron Microscopy Figure 2 : Microscope FIB-SEM Zeiss crossbeam XB 550 Image analysis : Semantic segmentation Deep Learning : nnU-Net Figure 3 : LSEC segmentation Ilastik software • Workflow Carving • Watershed method group of supervoxels • Workflow Pixel Classification • Random Forest Classifier pixels features • nnU-Net : Convolutional neural network (CNN) architecture Model tested on data from Medical Segmentation Decathlon Train from a labeled set of Ground Truth Optimising training nnU-Net : Python code in progress Figure 4 : Hepatic sinusoid segmentation mask : Ground Truth ACKNOWLEDGEMENTS – This research is part of the LabEx GRAL. This project received funding from the Chemistry Biology Health (CBH) Graduate School of University Grenoble Alpes (ANR-17-EURE-0003). This work was also supported by the CEA DRF-Impulsion grant FIB-Bio and the Région Auvergne Rhône-Alpes. This project is supported by GRAL. This work uses the Nanocaracterisation platforms (PFNC) @ Minatec and also the ME platform of the Institute of Structural Biology (IBS). The EM facility is supported by the Auvergne Rhône-Alpes Region, the Fondation Recherche Medicale (FRM). I would like to thank Met&Or team for fruitful discussions. 4 Conclusion Perspectives • 3D Tissue environment • FIB-SEM acquisitions pixel size : 64nm𝟑and 1000nm𝟑 • Complexity of LSEC segmentation : difficult shape FIB-SEM acquisitions 2D image-stack registration 3D reconstruction Quantitative data : LSEC fenestration • Diameter, number, porosity of LSEC fenestration • Diameter between 50 and 300 nm • Defenestration liver diseases • Quantitative measurements of LSEC fenestration : method to be automated • Hypothesis to be confirmed : BMP9 maintains LSEC fenestration • Ability of the deep learning model nnU-Net to adapt to a new task nnU-Net : a deep learning-based segmentation method • Train the model on part of the sub-volume select a random region of the sub-stack by programming in Python • LSEC 3D Ultrastructure study LSEC fenestration closer to reality • Enhance our understanding on LSEC architecture in vivo Data volume : around 60 Go software limits large dataset size for segmentation software • nnU-Net generation of segmenta
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Comic Books in Translation: Process and Quality in Metaphor Translation Jisue Park (jisue.park@surrey.ac.uk) Study Aim Research Questions Participants Study design Results: Process The process of translating metaphors The final quality of metaphors The influence of MT on the human translation process RQ1 What is the process for translating metaphors in comic books? RQ2 Is the quality of the final product higher when translating from scratch or when MT post-editing? RQ3 Is the cognitive effort lower when translators MT post- edit metaphors than when they translate on their own? Translator (TR) Post-editor (PE) Reviewer (R) Translate without machine translation Translate with machine translation Assess the quality of translated metaphors - Google Translate - Korean → English An excerpt of comic book (189 words) Key-stroke data Screen-recording data Interview data Evaluation data Interview data Pre-questionnaire (Translators) Train translators Pre-experiment Main experiment Interview translators Pre-questionnaire (Reviewer) Review translations Train the reviewer Interview reviewer Analyse results Percentage of pause length for each translation phase Translator Post-editor Translation phase classified by Jakobsen (2002) Metaphor TR version PE version Label Pause length Label Pause length #1 Good 01:20.625 Fair 01:26.437 #2 Fair 00:12.187 Fair 00:50.750 #3 Poor 01:08:264 Fair 02:00.781 #4 Fair 01:06.999 Fair 01:06.344 #5 Fair 00:40.796 Poor 00:30.500 #6 Fair 00:39.282 Fair 00:24.328 #7 Poor 05:40.578 Fair 05:40.312 Total - 11:48.731 - 11:58.452 Average - 01:41.142 - 01:42.571 Results: Quality Reviewer ranking & links between effort and pauses Pausing is an indicator of mistrusting machine translation. Higher effort does not equal high quality. References Jakobsen, A. L. (2002). Translation drafting by professional translators and by translation students. Copenhagen studies in language, 27, 191-204.
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M. Ponzelli1, R. Moreno1, I. Etxeberria2, A. Artola2, A. Barrio2, N. Mattar3, W. Pitacco4, L. Staccioli5, O. Reyes5, J. Gallego5, C. Pagella6, I. Deligkiozi1 This project has received funding from the Bio-based Industries Joint Undertaking (JU) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101023342. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Bio-based Industries Consortium. BIO-BASED SUSTAINABLE COATINGS WITH LIGNIN RESINS FOR ENHANCED PERFORMANCE AND ENVIRONMENTAL IMPACT 1 AXIA Innovation GmbH, Fritz-Hommel-Weg 4, 80805, Munich, Germany 2 TECNALIA, Mikeletegi Pasealekua 2 Parque Científico y Tecnológico de Gipuzkoa, 20009 Donostia-San Sebastian, Gipuzkoa, Spain 3 ECOAT, ZI Des Bois De Grasse, 1 avenue Louison Bobet, 06130, Grasse, France 4 AEP Polymers SRL, AREA Science Park, Strada Statale 14, km 163.5, 34149 Basovizza, Trieste, Italy 5 ARDITEC Association, 7 Av. De Fabron, 06200, Nice, France 6 IRIS Coatings SRL, Via Novi 42, 15060, Basaluzzo (AL), Italy @LIGNICOAT BBI Project @LIGNICOAT BBI Project www.lignicoat.eu info@lignicoat.eu Sustainable coatings based on lignin resins and bio-additives with improved fire, corrosion and biological resistance Materials and Methods Introduction and Background Coatings play a crucial role in our daily existence by offering protection, enhancing aesthetics, and providing functionality to different surfaces. Nevertheless, the environmental repercussions associated with coatings derived nowadays from fossil fuels and the emission of volatile organic compounds (VOCs) have prompted concerns. Towards the road of defossilization and the creation of a sustainable bioeconomy, the LIGNICOAT project is developing innovative lignin-based resins and coatings. Lignin, a by-product of lignocellulosic biomass, is a natural polymer that can be used as a building block for producing biobased resins. LIGNICOAT particularly targets biobased coating with enhanced properties in terms of fire, corrosion, and antimicrobial resistance. 1 Materials: The development of biocoatings includes: • Bio-PUD resins, synthesized from lignin polyols *. • Phosphorous-based flame-retardant additives. FR water-borne biocoatings are applied on wood substrates as an FR alternative to market solvent-borne coating (CHAR18, IRIS Coatings). Methods: • Hardness by Persoz Pendulum. • Transparency and colour by colorimetry. • Fire performance evaluation by cone calorimeter on particleboard (PB) at a heat flux of 35 kW/m2. INTERMEDIATES LIGNIN RESINS COATINGS • Kraft Lignin • Organosolv Lignin Fire protection Anti-corrosion Anti-microbial, anti-viral & VOCs degradation • Lignin Polyols • Lignin Polyacids • Epoxidized Lignin • Polyurethane • Alkyd • Epoxy • Wood • Metal • Bio-PUD coatings without any FR additives (Bio_1 and Bio_2) showed even worse fire resistance behaviour than the PB without coating. • FR additives (P or Cl) significantly improved the fire performance of Bio-PUD coatings (Bio+FR_1, Bio+FR_2, and Bio+FR_3). • The developed FR water-borne biocoatings have similar fire performance to the market benchmark in terms of heat release. • The biocoating Bio+FR_3 could be a suitable candidate for replacing fossil-based ones as a 26%, and 38% improvement of the maximum average rate of heat emission (MARHE) was noticed compared to the market reference and the PB with no coating, respectively. Coating Composition NCO % Bio- based tIGNITION (s) HRR Peak (kW/m2) MARHE (kW/m2) TSP (m2) Persoz Hardness (s) Colour dE*ab (D65) No coating - - - 67 208 89 2.3 - - Market Solvent-borne PU 2K (10% Cl) HNCO 0% 67 176 75 3.5 115 2.4 Bio_1 Bio_PUD - 46% 43 197 95 3.4 55 17.4 Bio_2 Bio_PUD HNCO 42% 45 214 94 2.5 62 17.2 Bio+FR_1 Bio_PUD + 15%P + 3%Cl HNCO 47% 35 179 67 2.4 29 12.6 Bio+FR_2 Bio_PUD + 15%P + 3%Cl Bio- HNCO 50% 38 186 73 2.9 19 17.8 Bio+FR_3 Bio_PUD + 20%P + 1%Cl HNCO 47% 41 137 55 2.3 26 16.5 0,00 1,00 2,00 3,00 4,00
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RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com Electronic Health Records (EHR) provide a rich source of population data that can be used to systematically understand multimorbidity. Robust measures of association are hypothesis-generating if their co-occurrence is higher than expected. However, prevalent methodological framework are unstable when evidence is limited. Associations between conditions canbe assembled into a network of multimorbidity, where network analysis can be used to understand the role of diseases, find clusters, or study disease progression. The effects of unreliable association measures get aggregated and intensified when performing network analysis. These problems affect particularly to minorities (small but important subgroups), for which there is less data available. We have developed a Bayesian inference framework that is robust to sparse data in the analysis of multimorbidity patterns. The framework also has the following benefits: - Explicit estimation of uncertainty - Robust to decisions in the methodology - Robust to noise in rare conditions Background and motivation Methods Retrospective cross-sectional study of a representative dataset of primary care patients in Scotland as of March 2007. We included 40 long-term conditions and studied their associations in 12,009 individuals aged 90 and older, stratified by sex (3039 men, 8970 women) We analysed associations obtained with Relative Risk (RR), a standard measure in the literature, and compared them with our proposed measure, Associations Beyond Chance (ABC). To enable a broad exploration of interactions between long-term conditions, we built networks of association and assessed differences in their analysis when associations are estimated by RR or ABC. Results Our Bayesian framework was appropriately more cautious in attributing association when evidence is lacking, particularly in uncommon conditions. This caution in reporting association was also present in reporting differences in associations between sex and affected the aggregated measures of multimorbidity and network representations. Incorporating uncertainty into multimorbidity research is crucial to avoid misleading findings when evidence is limited, a problem that particularly affects small but important subgroups. Our proposed framework improves the reliability of estimations of associations and, more in general, of research into disease mechanisms and multimorbidity. Multimorbidity analysis with low condition counts:​ A robust Bayesian approach for small but important subgroups​ Guillermo Romero Moreno, Valerio Restocchi, Jacques Fleuriot, Atul Anand, Steward Mercer, Bruce Guthrie Conclusion Reference Romero Moreno G., Restocchi V., Fleuriot J., Anand A., Mercer S., Guthrie B., “Multimorbidity analysis with low condition counts:​ A robust Bayesian approach for small but important subgroups”​, eBioMedicine, Volume 102, 2024, 105081, https://www.sciencedirect.com/science/article/pii/S2352396424001166​ This study/project is funded by the NIHR under the AI for Multiple Long-Term Conditions (AIM) programme, NIHR202639. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Model This model of multimorbidity generation assumes: i) hypothetical risk factors affecting the appearance of each LTC independent of the others, ii) hypothetical common mechanisms that simultaneously affect a pair of LTCs and lead to their co-appearance, e.g. common risk factors or one LTC increasing the risk of acquiring the other. ABC reflects the ratio of generation by common mechanisms as compared to independent factors: ABC = 1 + fij / fi fj These are then embedded in a fully Bayesian framework: Priors Code The code for implementing our framework is publicly available at https://github.com/Juillermo/ABC. It has also be published as an easily installable python package, via pip install abc-network ( https://pypi.org/pro
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TITULO CONDRODISPLASIA PUNTEADA DE TIPO DOMINANTE, LIGADA AL CROMOSOMA X. (SINDROME DE CONRADI-HUNERMANN). CASO CLINICO Autores: Dra. Idarmis Jiménez, genética clínica; Dra. Nelly Báez, neonatóloga; Dra. Susy Ampudia, pediatra; Dra. Audrey García, pediatra; Dr. Alejandro Montes, médico ocupacional. INTRODUCCIÓN El síndrome de condrodisplasia punteada descrito por Conradi y por Hunerman, se caracteriza por deficiencia del crecimiento entre leve y moderada, dismorfias faciales como puente nasal deprimido, cara plana, hipoplasia de las eminencias malares con fisuras palpebrales descendentes. Orejas displásicas, alteraciones oculares como nistagmos y catarata. Presenta además calcificaciones traqueales con estenosis asociada de la tráquea, acortamiento asimétrico relacionado con áreas de mineralización punteada en las epífisis, contracturas articulares variables, escoliosis relacionada con áreas de mineralización punteada y calcificaciones paraespinales. En piel puede encontrarse escamas adherentes gruesas, atrofodermia folicular variable, con poros grandes, ictiosis y alopecia. Luxación de rotula y defectos cardiacos. CASO CLÍNICO Recién nacido por cesárea producto de 4ta gestas, le anteceden 3 abortos espontáneos, madre de 31 años con antecedentes prenatales por ecografía de ausencia de hueso nasal y huesos largos cortos, por lo que se realiza estudio citogenético molecular mediante sonda FISH en líquido amniótico y no se encontró alteración numéricas de los cromosomas estudiados 13, 18, 21, X, Y. Nace con un peso de 2914 g y talla 36,5 cm, leve acortamiento risomélico de huesos largos, cuello corto y tórax corto con teletelia. Facies grotesca, puente nasal muy plano, hipoplasia del tercio medio de la cara, nariz pequeña, macroglosia y dificultad respiratoria, por lo que necesitó oxígeno hasta los 2 meses de vida. Pie con camptodactilia del 4to dedo e hipoplasia ungueal, además de soplo cardiaco sistólico grado II/VI. BIBLIOGRAFÍAS 1-SMITH. Patrones Reconocibles de Malformaciones Humanas, ElSEVIER España; 2007; 6e ed. en español. 2-CRUZ HERNANDEZ/ BOSCH HUGAS, Atlas de Síndromes Pediátricos. ESPAXS, España; 1998; 01 ed. DISCUSIÓN La Condrodisplasia Punteada puede encontrarse en un sinnúmero de diferentes enfermedades genéticas. Puede ser adquirida intrautero por exposición de la madre o con patrón de herencia autosómica dominante, autosómica recesiva, ligada al sexo recesiva y dominante. La mineralización punteada temprana y poros cutáneos grandes durante la primera infancia, producen un fallo de medro e infecciones. Regularmente es letal en el hombre y muchos fallecen en etapa neonatal, si el paciente sobrevive durante los primeros meses, el pronóstico es bueno. El punteado de las epífisis de los huesos largos se suele resolver hacia los 9 meses, son frecuentes los problemas ortopédicos y hay riesgo alto de cataratas. Existen unas 15 mutaciones de un gen ligado al cromosoma X como deleciones, translocaciones y puntuales localizados en (Xp22.3). El diagnóstico más probable de nuestro paciente es el síndrome de Conradi-Hunerman y se realizó por la clínica, estudio de imágenes y antecedentes maternos de 3 abortos con diferente pareja pudiera sugerirlo también. En Rx de cráneo y cara huesos propios de la nariz: protuberancia frontal, ausencia de hueso nasal. Rx de tórax: se observa calcificaciones punteadas a nivel de los cartílagos en toda la columna dorso-lumbar y calcificaciones punteadas en articulación acromio-clavicular y glenohumeral. Ecocardiograma: PCA, CIA tipo os. CONCLUSIONES El estudio molecular es el diagnóstico definitivo de las enfermedades genéticas de origen génico. Debido a la heterogeneidad genética del síndrome, la orientación genética debe ser el pilar de prevención de este síndrome. El tratamiento es sintomático y aun no existe uno específico. PRIMERA JORNADA MÉDICA ACADÉMICA DE BIENESTAR MATERNO-NEONATAL Y GINECOLÓGICO “HGOIA”
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Re-Executability Assessment of the Recent Autism Literature David Kennedy, Christian Haselgrove, Steve Hodge, Leah Honor, Jean Frazier University of Massachusetts Medical School, Worcester, MA, USA Introduction: There is concern about the stats of reproducibility in science in general and neuroimaging neuroscience in particular (Gorgolewski and Poldrack 2016; Button et al. 2013). A particularly germain concern was expressed by Insel and colleagues in lamenting: “a profusion of statistically significant, but minimally differentiating, biological findings; ‘approximate replications’ of these findings in a way that neither confirms nor refutes them” (Kapur, Phillips, and Insel 2012). The replication of a specific finding (or reproducibility of a specific analysis), as reflected in a publication, has many details and nuances to it (Kennedy et al. 2019). Often, we are searching for the ‘generalizability’ of a finding: does the finding hold true when using ‘similar’ data and a ‘similar’ analysis. In this poster, we: 1) develop a specification for what constitutes an assessment of the re-executability for a given publication, in each of the domains of: data, software, execution environment, statistics and results; 2) codify this assessment in survey form; and 3) apply the survey to a subset of the autism neuroimaging literature published recently (~2018). From the results of this survey, we can begin to generalize the state of the re-executability of the recent autism neuroimaging literature, in order to identify trends and opportunities for the enhancement of the re-executability status in support of greater overall generalizability (and hence reproducibility) of the literature. Methods Survey Development: In order to assess the prospects of re-execution of a given paper, we assess 1) the availability of the starting data, 2) the precision of the analysis description (both data processing and statistical assessment), and 3) the availability of the detailed complete results (in order to verify accuracy of re-execution). Regarding the ‘availability of the starting data’, we assess if the publication indicates how someone (other than the authors themselves) could appropriately access the data. The ‘precision of the analysis description’ ultimately asks if a reader who is reasonably skilled in the necessary domains, could precisely carry out the prescribed analysis steps. Specifically, are the software versions, operating system and complete parameters somehow made available to the reader? The ‘detailed complete results’ assesses if the publication indicates how to obtain the complete results, in order to both verify that the re-execution generates the same result and to overcome the limitations of selected summary only being presented, which impedes a more complete meta analysis of the literature. Literature Identification: On January 23, 2019, the following pubmed query was executed: (("autistic disorder"[MeSH Terms] OR ("autistic"[All Fields] AND "disorder"[All Fields]) OR "autistic disorder"[All Fields] OR "autism"[All Fields]) AND ("magnetic resonance imaging"[MeSH Terms] OR ("magnetic"[All Fields] AND "resonance"[All Fields] AND "imaging"[All Fields]) OR "magnetic resonance imaging"[All Fields] OR "mri"[All Fields])) AND ("2014/01/25"[PDat] : "2019/01/23"[PDat] AND "humans"[MeSH Terms]) This is the expansion of the general query for ‘autism AND MRI, qualified to select publications between 1/25/2014 - 1/23/2019 and where the MeSH term includes ‘human’. This query generated 811 resultant publications at the time of the query. Figure 1: Overview of the survey design. Data Availability: Sixteen of the 50 (32%) publications make reference to the availability of the data used in the publication. However, publications that indicate availability are reusing data from the large repositories, whereas the publications that do not indicate data availability are principally locally conducted studies. Thus, this indicates that a large fraction
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Model Annotation The figure below presents some of the information with which we have enriched a cohort of kidney models meta-data in the form of semantic annotations available in the Physiome Model Repository (PMR). In particular, we extracted each of the mathematical variables from the models and associated them with a biologically meaningful knowledge. Model Discovery Utilizing these biological annotations, we are able to frame queries to PMR using biologically relevant terms. Our prototype web interface presents the search results obtained from querying the PMR services with the biological context; including models of similar biology and a recommender system. Background Model Composition Once a user is satisfied with the model built and graphically edited using our platform, they will then be able to generate a novel model meeting their requirements. Utilizing the modularity and reuse capabilities of CellML, we are able to create a new CellML model by directly reusing and customizing the existing models discovered by the user. Model Verification For testing purpose, we have begun implementing a verification system which allows users to discover simulation experiments which match the features of the novel models users create. By executing these simulation experiments with the novel models and comparing to previous model predictions and/or experimental or clinical observations we are able to provide the user with some measure of verification that their model matches, or doesn’t match, existing knowledge captured in the various repositories utilized. Epithelial Modelling Platform: A Tool for Investigating Hypotheses through Discovery and Assembly of Computational Models of Epithelial Transport Dewan M Sarwar (dsar941@aucklanduni.ac.nz), Koray Atalag, Peter J Hunter, David P Nickerson (d.nickerson@auckland.ac.nz) Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand Acknowledgements This poster at Scientists often leverage computational models of biological systems to investigate hypotheses which are difficult or prohibitively expensive to achieve experimentally. Such investigations are best achieved by utilizing suitable computational models, reusing existing validated models where possible and creating novel models consistently as needed. This requires tools which enable the discovery and exploration of existing models matched with assistance in constructing and testing new models. Enabling biomedical engineers to use such a tool by allowing them to describe their requirements in a manner familiar to them greatly improves the utility of the tool. This tool is not quite ready for pure biologists or clinicians to use. We have developed a web-based tool, the Epithelial Modelling Platform, for discovery of relevant models and assemble them into a novel model customized for investigating their hypotheses. While our tool specifically focuses on epithelial transport, by utilizing relevant community standards and publicly accessible knowledge repositories, it is extensible to other areas of application. The platform abstracts underlying mathematics of the computational models and provides a visual environment which mimics biophysical phenomena of an epithelial cell. Presented below is an overview of our knowledge management platform being developed and utilized in this work. Modeling Platform Presented on the top-right column is the web-based epithelial modelling platform to discover, explore and assemble models where users would be able to create and verify new epithelial models. This platform allows users to drag and drop models between apical and basolateral membranes. Solutes, e.g. sodium, potassium, will be floating in specific compartments. Modelers and clinicians can use this platform to build models to help investigate specific research questions and hypotheses. https://github.com/dewancse/model-discovery-tool https://github.com/dewancse/epithelial-modelling-platform
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Benchmarking New Hardware for Machine Learning for Particle Physics Cavendish Laboratory, Department of High Energy Physics, University of Cambridge Stefano Vergani 4. Specs of Different PUs For this study, three different types of PUs will be used. They have different specifics, prices, and energy consumption and all of them must be taken into account when choosing the right one. 1. LArTPC Detectors • Liquid argon time projection chamber (LArTPC) detectors measure ionisation tracks produced by charged particles inside a cryostat filled with liquid argon. • The ionisation electrons drift in an electric field towards wire planes, where their charge is collected and measured. • For this work, a fictitious LArTPC detector has been simulated with GEANT4. 5. Neural Networks 2. Processing Units A Processing Unit (PU) is a circuit which performs operations. There are several of them: • Central Processing Unit (CPU): processes the basic instructions that drive a computer • Graphics Processing Unit (GPU): used in graphic rendering software and in video games. In recent years, it has been used also to perform matrix calculations for Deep Learning (DL) • Neural Processing Unit (NPU): a special groups of PUs designed specifically to perform matrix calculations for DL References: • [1] MicroBooNE Collaboration, JINST 12, P02017 (2017), ArXiv: 1612.05824v2 • [2] https://coral.withgoogle.com/products/accelerator Notes: *There is currently a known issue in the quantization of TF Lite models meaning that the accuracy of inference on the Edge TPU is not representative, and is hence not given here at this stage. The accuracy is expected to be identical between the CPU, GPU (as demonstrated) and Edge TPU, and this will be verified in the near future Only a certain subset of possible Neural Networks (NNs) can run on an Edge TPU. Among them, Residual Network 50 (ResNet-50) V2 and DenseNet-169 have been identified as the most promising. They have been trained with 10k images equally divided between neutrino Neutral Current (NC), νμ Charged Current (numu CC), and ν𝒆Charged Current (nue CC) events. Validation has been done with another set of 2k images equally divided between NC, numu CC, and nue CC events. Training and validation have been done using the popular TensorFlow software. 3. Tensor Processing Unit Tensor Processing Units (TPUs) are a subset of NPUs designed by Google to do tensor calculations. Edge TPU has portable sizes (65 mm x 30 mm). They have a very low power consumption and come at a cheap price (~80 USD). Figure 2: Picture of an Edge TPU compared to the size of a clip. Taken from [2]. 6. TensorFlow Lite 7. Results and Future Work The TensorFlow (TF) trained models have been subsequently converted to all the available TF Lite optimizations to test their speed and accuracy on CPU, GPU, and Edge TPU. The idea behind TF Lite is to make a lighter and faster model using quantization, that is converting weights and/or activations into 8 bits or float 16. This could lead to some accuracy loss. Edge TPU works only with quantized models. Table 2 presents a comparison between different versions of TensorFlow Lite. Table 2: Comparison between features of different TF Lite Optimizations. • TensorFlow Lite appears to be particularly useful for users with limited RAM on the CPU/GPU. • Edge TPU could be an interesting solution for users who cannot afford a GPU. Research centers could equip each workstation with one. Interesting for future R&D in edge computing for particle physics. • Future plans comprehend testing more NNs and a publication. Figure 1: On the left, sketch of a LArTPC taken from [1]. On the right, ionisation 𝑒− collected in the three different wire planes, from a fictitious LArTPC simulation. Processor Type CPU GPU EDGE TPU Model Intel ® Core ™ i7- 8550U @ 1.8 GHz NVIDIA Tesla P100 16 GB Coral Edge TPU TDP* (in w) 15 250 2 Commercial Price 99 USD 7500 USD 80 USD Table 1: Specifics of all the PUs used for this study. * Thermal Design
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2763/ P229. Quantifying the DARTable Genome for Prediction of Teratogenic Doses - a case study using retinoic acid pathway-induced developmental toxicity R. A. Currie1, N. Principato2, T. B. Knudsen3, A. R. Kaczor4, L. Yu5, A. Letamendia6, A. H. Piersma7, and S. Mitchell-Ryan8. 1 Syngenta International Research Centre, United Kingdom; 2 Syngenta Crop Protection, Greensboro, NC; 3 EPA, Research Triangle Park, NC; 4 Merck & Co., Inc., West Point, PA, USA; 5 NCTR, FDA, Jefferson, AR; 6 Bayer Crop Science, Sophia Antipolis, France; 7 RIVM, Bilthoven, Netherlands; and 8 HESI, Washington, DC. In vitro assay potency: databases, patents, regulatory documents Pharmacokinetic data at N/LOEL: literature, TK elements of toxicity reports, regulatory documents In vivo toxicity: toxicology study reports, literature, regulatory documents Calculate Threshold Ratio using potency, PK and toxicity data This poster does not reflect EPA or FDA policy. • The goal of the HESI DARTable Genome Working Group is to build a compendium of quantitative molecular initiating events (MIEs) and key event biomarkers for teratogenicity prediction. • Our initial case study focused on an AOP framework linking adverse developmental outcome(s) to perturbation of each of the three retinoic acid receptor isotypes: alpha (RARa) , beta (RARb) and gamma (RARg). • This investigation focused on the relationship(s) between chemical potency on RAR targets and the quantitative threshold of maternal systemic exposure necessary to produce a teratogenic outcome. 2. Building a quantitative model for the DARTable genome: all-trans retinoic acid (ATRA) signaling. 1. Introduction This model can be used to calculate a Threshold Ratio of exposure below (or above) which the likelihood of a chemical causing a toxicity by that AOP is low (or high). 3. Reference Compounds. • For 20 compounds with known retinoid agonist or antagonist activity we compiled RAR potency for each RAR-isotype, including pharmacokinetic and toxicology information for rat and rabbits. • Here, we present results for 3 retinoids that had complete data in the rat, and 2 of which also had suitable rabbit data. 4. Results of Threshold Ratio visualization on 3 retinoid case examples. • We calculated Threshold Ratios for each RAR isotype utilizing the estimated dam or doe steady- state blood concentration at the NOEL and LOEL. • Model returns a Threshold Ratio for exposure- biological potency driving developmental toxicity at each RAR isotype. • An exposure-potency threshold > 2 for RARa or RARg best characterized LOELs for retinoid developmental toxicity; RARb did not fit the pattern. 5. Conclusions, lessons learned and next steps • The model derived DART-predictive exposure-potency Threshold Ratios to predict developmental toxicity; PK data was the largest missing data type. • Toxic responses considered as thresholds were driven by RARa or RARg from public data sources; however, RARb did not fit the pattern. • Relevant data overall can be unstructured or incomplete and difficult to find, access, or compile into a computable model. • ‘FAIR’ data principles are vital to enable sharing of the toxicity, potency and pharmacokinetic data for predictive toxicology. • It will be informative to determine if patterns for retinoid-based RAR target ratios generalize to chemicals that alter ATRA metabolism. • The next case study selected for the DARTable genome will focus on Thalidomide-like compounds. NOEL LOEL NOEL LOEL RARa 1.3 2.9 nd 1.91 RARb 0.10 0.22 nd 0.14 RARg 0.29 0.65 nd 0.43 RARa 0.01 0.03 0.002 0.02 RARb 0.04 0.12 0.008 0.06 RARg 0.69 2.1 0.126 1.04 RARa 0.65 13 nd nd RARb 2.8 57 nd nd RARg 0.65 13 nd nd Rabbit ratio compound receptor alitretinoin tazarotene trifarotene Rat ratio
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These were drawn from theories of Visual Cognition and from requirements gathered from our experimental trials. ROBOTS WITH COMMON SENSE Improving Sensemaking in Service Robotics NAIVE PHYSICS LEARNING MODEL BUILDING FAST PERCEPTION We derived a set of "ingredients", i.e., required knowledge capabilities, for robots to exhibit human-like performance on sensemaking tasks. We identified the types of common sense knowledge which enable these capabilities. Hypothesis: the integration of common sense knowledge and knowledge-based reasoning with Machine Learning improves a robot's sensemaking capabilities. COMPOSITIONALITY INGREDIENTS OF VISUAL INTELLIGENCE Infants can already grasp basic principles of Physics before 6 months of age. Hence, large amounts of background knowledge are needed to help a robot to correctly interpret the observed scenario. The shiny object is NEXT TO a keyboard GENERIC 2D VIEWS MOTION VISION MACHINE READING Service robots assist humans by performing tasks in a variety of scenarios, including shops, restaurants, healthcare, delivering parcels, accessing hazardous environments, and others. PhD Student: Agnese Chiatti Supervisors: Enrico Motta Enrico Daga Our visual perception is extremely fast and we can learn to recognize new objects even from our very first exposure to them. The ability to read text from images is essential to recognize labelled items and signs. We categorise objects and actions differently based on the perceived movement (or lack thereof). FOCUS ON VISUAL INTELLIGENCE RESEARCH PROBLEM PROPOSED APPROACH The images cast at the back of our eye are 2-dimensional. We construct the 3D mentally. MEET HANS! Web: https://robots.kmi.open.ac.uk Methods based on Machine Learning have shown promising results. Nonetheless, machine Visual Intelligence is still inferior to human Visual Intelligence in many ways. The human eye identifies the different objects parts and the different nearby objects separately. Our hypothesis is being tested in the case of HanS, the Health & Safety robot inspector currently under development at KMi. Service robots need to make sense of complex and fast-evolving environments. They do so by using their perceptual sensors (e.g., vision, depth, touch) to identify the objects around them. However, different objects can look very similar to a robot (e.g., in certain light conditions the shiny surface of a radiator may look like a screen to a robot) It is a monitor, not a radiator. Our work focuses on the robot’s capability to use its vision system, reasoning components and background knowledge to make sense of its environment. Photo credits: Enrico Motta, Agnese Chiatti
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References Funder, D. C., & West, S. G. (1993). Consensus, self-other agreement, and accuracy in personality judgment: An introduction. Journal of Personality, 61(4), 457-476. Retrieved from http://ezproxy.middlebury.edu/login?url=http://search.proquest.com/d ocview/618476264?accountid=12447 Lindová, J., Hrušková, M., Pivoňková, V., Kuběna, A., & Flegr, J. (2008). Digit ratio (2D:4D) and cattell's personality traits. European Journal of Personality, 22(4), 347-356. doi: http://dx.doi.org/10.1002/per.664 Lutchmaya, S., Baron-Cohen, S., Raggatt, P., Knickmeyer, R., & Manning, J. T. (2004). 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Human Development, 77(1-2), 23-28. doi: http://dx.doi.org/10.1016/j.earlhumdev.2003.12.002 Sellers, J. G., Mehl, M. R., & Josephs, R. A. (2007). Hormones and personality: Testosterone as a marker of individual differences. Journal of Research in Personality, 41(1), 126-138. doi: http://dx.doi.org/10.1016/j.jrp.2006.02.004 http://www.handresearch.com/news/five-fingers-relate-to-evolution- sports-behavior-disease-sex.htm http://www.epa.govt.nz:80/about-us/have-your-say/Pages/default.aspx Prenatal Testosterone and Self-Report Predicts Others’ Perceptions of Leadership Behaviors Kristina Conroy, Scarlett Kirk, Madeline Brooks, and Jennifer Guinn Sellers Abstract INTRODUCTION: Past research has demonstrated a relationship between the 2D: 4D ratio and prenatal testosterone exposure. (Lutchmaya et al., 2004) The 2D:4D ratio is calculated by dividing the length of the pointer finger (2D) by the length of the ring finger (4D) of the right hand. Individuals with a lower 2D: 4D ratio are thought to have experienced higher testosterone in utero. Relatedly, circulating testosterone has been found to influence certain personality characteristics such as dominance. The present study investigated the relationship between the 2D:4D ratio and leadership as a personality variable while looking at self report and informant reports of leadership. METHOD: 141 female undergraduate students at Middlebury College were recruited. Participants were asked to complete the experiment with a close friend or teammate. They were asked to have their right hand scanned, to answer a series of questions about their own leadership tendencies, and to answer a series of questions about the person with whom they completed the experiment. RESULTS: A 2x2 ANOVA revealed that finger length and self-report of leadership independently indicated informant report of leadership. Participants with a lower ratio who reported themselves as high on leadership scored the highest on informant leadership. DISCUSSION: Our findings indicate that testosterone exposure lies outside the individual’s awareness, but is perceived by close friends and acquaintances. This research shows the potential of testosterone and the 2D: 4D ratio to add to our understanding of personality and personality assessment. Discussion Consistent with predictions, those with lower finger ratio scored higher on the informant report of leadership, and those with higher self-report of leadership also scored higher on informant measures of leadership. The lack of significance in comparing solely the self-report leadership and finger ratio shows that the influence of testosterone exposure lies outside the individual’s awareness, but is perceived by close friends and acquaintances. Limitations: Most participants were recruited via convenience. Additional research should likewise change the operationalization of leadership. Future Research: These findings have the potential to be useful in a number of divisions of psychology. Most significantly, the study strengthens research on the 2D: 4D ratio and its ability to provide alternative ways in measuring testosterone. The results also further our understanding of hormones’ influence over personality, and that informant reports of hormonal markers can add new insights. The findings also indicate that informant reports to pre
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(Halperin et al., 2018) CyDIVE: Targeted hypermutation system for cyanobacteri> I Active module from EvolvR (Halperin et al., 2018 I Dynamic expression by rhamnose inducible promoter (Kelly et al., 2018 I Extra repression by theophylline riboswitch (inspired by Liu et al., 2020 I Multiplexed gRNA array & counter selection by MazF (Cengic et al., 2022 I Broad host RSF1010 backbone In vivo directed evolution platform development In vitro variant library generation & directed evolution In silico: D1 structural modelling to identify potential engineering target 832 D1 sequences inc. Eukaryotic D1s Structure prediction by AlphaFold2 Global structural alignment by mTM-Align Literature survey on D1 mutagenesis study “Common core” Main variable regions AA222-267 “D-E loop” AA295-317 24 representative D1s structural alignment Evolutionary engineering of Photosystem II: by far, by nature (Oliver et al., 2023) Photosystem II: Ever evolving enzymq I Great knowledge on how standard PS II works, but less on divergent typed I Functional diversity of PS II shaped by natural evolution is reflected in reaction centre protein D1 subunit diversity: Modular tuning mechanism_ I Std D1, D1’ (microoxic), rD1 (?), srD1 (Chl f synthase I Harnessing evolution as an engineering tool: Focusing on D1 as primary target, directed evolution is applied to engineer PS II beyond its known functional horizon Department of Life Sciences, Imperial College London, London, United Kingdom tom.kim@imperial.ac.uk Tom Dongmin Kim§, Daniella Pretorius, Wenxin Li, Francesca Levi & Tanai Cardona Directed evolution of Photosystem II: Status update and structural modelling for targeted engineering
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FLORE CLAUS PHD RESEARCH (2020-2026) DEPARTMENT OF CRIMINOLOGY, CRIMINAL LAW AND SOCIAL LAW INDIVIDUAL & COLLECTIVE INTERNATIONAL & NATIONAL W H Y ? Lifelong learning contains all learning activities from the moment you’re born until you die. However, not everyone gets an opportunity to learn throughout their life. Some vulnerable groups are left behind based on who they are (low-skilled, old or disabled) or where they work (sector, seize of the company). Unlike socio-economic (inter)national studies on lifelong learning, little attention is paid to the legal perspective. This doctoral research draws attention to how lifelong learning is integrated in the employment relationship through several regulations, more specifically the legal bottlenecks and possible changes in order to promote lifelong learning for vulnerable groups. Lifelong learning contains all learning activities from the moment you’re born until you die. However, not everyone gets an opportunity to learn throughout their life. Some vulnerable groups are left behind based on who they are (low-skilled, old or disabled) or where they work (sector, seize of the company). Unlike socio-economic (inter)national studies on lifelong learning, little attention is paid to the legal perspective. This doctoral research draws attention to how lifelong learning is integrated in the employment relationship through several regulations, more specifically the legal bottlenecks and possible changes in order to promote lifelong learning for vulnerable groups. NATIONAL & REGIONAL SEMI-STRUCTURED EXPERT INTERVIEWS VIGNETTE METHOD LEGAL ANALYSIS VIGNETTE METHOD LEGAL ANALYSIS LEGAL ANALYSIS LEGAL ANALYSIS L E T ' S T A L K ! Are you intrigued after exploring this topic? Feel free to scan this QR code and share your thoughts, I'm eager to learn from your insights! Interested in some of my findings? Scan this QR-code for my recent research paper (work in progress). Are you intrigued after exploring this topic? Feel free to scan this QR code and share your thoughts, I'm eager to learn from your insights! Interested in some of my findings? Scan this QR-code for my recent research paper (work in progress). W H A T ? Regulation of lifelong learning is scattered at different levels. This unique legal perspective does not focus on one particular regulatory level (national, international...) but includes different policy levels and how they are intertwined. The focus will be on three areas of regulatory tension. Two research questions are central. First, the right to lifelong learning in international context has to be delineated to understand the impact on the regulatory discretion of the national and sub-state levels. The second and main research question, tangles the right to lifelong learning from a bottom-up case study analysis. To align legal findings with real-life experiences of lifelong learning in the workplace, a triangulation of methods will be used. The experiences from five micro-enterprises of three sectors (hospitality, construction and trade) in the Flemish Region will be gathered using the vignette method. Regulation of lifelong learning is scattered at different levels. This unique legal perspective does not focus on one particular regulatory level (national, international...) but includes different policy levels and how they are intertwined. The focus will be on three areas of regulatory tension. Two research questions are central. First, the right to lifelong learning in international context has to be delineated to understand the impact on the regulatory discretion of the national and sub-state levels. The second and main research question, tangles the right to lifelong learning from a bottom-up case study analysis. To align legal findings with real-life experiences of lifelong learning in the workplace, a triangulation of methods will be used. The experiences from five micro-enterprises of three sectors (hospitality, construction and trade) in the Flemish Region will be g
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Characterization of Actinobacteriophage LittleTokyo Reveals Variable Diversity Within Cluster AS ●Phages possess incredible genetic diversity; however, there is a very small number of sequenced phages (Pope et al., 2017) ○Many phages are poorly characterized due to a lack of information ○There is limited information on Arthrobacter phages, as only 270 are currently sequenced ●One of the ways in which phages are classified is by placing them into clusters ○Clusters are groups of phages that have high nucleotide sequence similarities, shared life styles, and shared unique genes ●This project sequenced and classified a novel Arthrobacter phage, LittleTokyo ○LittleTokyo belongs to cluster AS ■Has three subclusters: AS1, AS2, and AS3 ■Formed in 2018, when phage Galaxy was found to be sufficiently similar to Abidatro (Klyczek et al., 2018) ●LittleTokyo is a temperate Arthrobacter globiformis phage ●TEM revealed LittleTokyo is a member of the Siphoviridae family through its icosahedral head diameter and tail length ●39.73% of genes were not assigned a function ●ANI heatmap and SplitsTree analyses show LittleTokyo is distinct from the AS2 subcluster ●Full genome Phamerator comparison reveals similarity between LittleTokyo and Kuleana that sets them apart from the AS2 subcluster ●Lysin A and Tape Measure Protein revealed inconsistent evolutionary origins ○In Lysin A, AS1 phages formed the outgroup from AS2 ○In TMP, AS1 phages were more closely related to the rest of the AS2 phages than LittleTokyo or Kuleana ●Evidence of horizontal gene transfer within the genome due to the presence of unique genes ○PAPS reductase-like domain ●Ackermann, HW. Bacteriophages: Methods in Molecular Biology, vol. 501, 2009, pp. 127-140. ●Dereeper, A. et al. Nucleic Acids Res, vol. 36, no. 2, 2008, pp. 465-469. ●Huson, DH. Bioinformatics, vol. 14, no. 1, 1998, pp. 68-73. ●Klyczek, KK. et al. Genome Announc, vol. 6, no. 5, 2018, pp. 1474-1517. ●Krumsiek, J. et al. Bioinformatics, vol. 23, no. 8, 2007, pp. 1026-1028. ●Papadopoulos, JS. and Agarwala, R. COBALT Bioinformatics, vol. 23, no. 9, 2007, pp. 1073-1079. ●Pope, WH. et al. mBio, vol. 8, no. 4, 2017, pp. 1069-1117. ●Savage, H. et al. Cell, 1997, vol. 5, pp. 865-906. ●Yoon, SH. et al. Antonie van Leeuwenhoek, vol. 110, 2017, pp. 1281-1286. Figure 1. LittleTokyo Genome Map A gene map of LittleTokyo was made using Inkscape and LittleTokyo’s genome from Phamerator. Highlighted genes represent genes of interest that were examined later in this project. The genome is 38969 base pairs long with 73 genes, 44 of which were assigned functions and 29 of which could not be assigned a function. Gene product functions were determined through Phamerator, PhagesDB, HHpred, the NCBI Basic Local Alignment Search Tool (BLAST), and the NCBI Conserved Domains Database (CDD). Annotated Genome of LittleTokyo Figure 2. TEM of LittleTokyo Transmission electron microscopy of LittleTokyo. Tail morphology was indicative of the Siphoviridae family. The tail was approximated to be 130 ± 2 nm and the head diameter was estimated to be 50 ± 2 nm. LittleTokyo Morphology Figure 3. Phamerator Genome Comparison Alignment of LittleTokyo’s genome with AS2 phages created through Phamerator and Inkscape. Comparison of LittleTokyo’s whole genome sequence to AS2 phages reveals higher synteny between LittleTokyo with Kuleana and slightly lower synteny compared to the other phages in the AS2 subcluster. (A) (B) Genome Comparison of Cluster AS2 Phages LittleTokyo is Distinct From Other Phages in Subcluster AS2 Figure 4. Phylogenetic Relationships of Cluster AS A Nexus file containing the shared gene content of the cluster AS and AZ phages was created using PhamNexus, which was used to create a SplitsTree diagram (Huson & Bryant, 2006). The AZ phages were included as an intercluster reference. In the tree, LittleTokyo and Kuleana are located on separate branches from the rest of AS2. The tree shows that LittleTokyo and Kuleana branch separately from o
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Method and data treatment Reanalysis of Titan INMS mass spectra Results About the homopause References Titan’s ionosphere was sampled by the mass spectrometer of the Cassini spacecraft many times during the course of the mission. Mass spectrometer analysis can be complicated, and identifying in which way a specie contribute to a mass peak is challenging. It is easier to fit the most abundant species, and trace species are often left unanalysed. Here we focus our work for now on 3 major species (N2,CH4, H2) and 1 trace specie (Ar). Consequences and prospectives Maélie Coutelier1, Thomas Gautier1, Koyena Das1, Joseph Serigano2 : maelie.coutelier@latmos.ipsl.fr 1 : LATMOS/IPSL, CNRS, Sorbonne Université, UVSQ, Guyancourt 2 : Morton K. Blaustein Department of Earth and Planetary Sciences, Baltimore 1: Cui, Jun, et al. "Analysis of Titan's neutral upper atmosphere from Cassini Ion Neutral Mass Spectrometer measurements." Icarus 200.2 (2009): 581-615. 2: Cui, J., et al. "The CH4 structure in Titan's upper atmosphere revisited." Journal of Geophysical Research: Planets 117.E11 (2012) 3: Mandt, Kathleen E., et al. "Ion densities and composition of Titan's upper atmosphere derived from the Cassini Ion Neutral Mass Spectrometer: Analysis methods and comparison of measured ion densities to photochemical model simulations." Journal of Geophysical Research: Planets 117.E10 (2012). 4: Magee, Brian A., et al. "INMS-derived composition of Titan's upper atmosphere: analysis methods and model comparison." Planetary and Space Science 57.14-15 (2009): 1895-1916. 5: Teolis, B. D., et al. "A revised sensitivity model for Cassini INMS: Results at Titan." Space Science Reviews 190.1 (2015): 47-84. 6: Gautier, Thomas, et al. "Decomposition of electron ionization mass spectra for space application using a Monte‐Carlo approach." Rapid Communications in Mass Spectrometry 34.8 (2020): e8684. Aknowledgment The funding for this research was provided by ANR (ANR “TOMTA”- ANR-20-CE49-0004-01) and PNP ●Calibration of INMS data using recommendations from previous works1,2,3,4,5 ●MS deconvolution code6 → Randomisation of the species fragmentation patterns between the allowed incertitudes → Monte-Carlo simulation. The code then try to fit at once all m/q peaks using the species in our database. → 100000 simulations → Allowed incertitude of 5% for the major species, and 30% for Argon. → Mean of the 5% best simulations. Global scale temporal variation clearly visible → Steady decrease of N2 mixing ratio and density until the vernal equinox. It increases until 2014 then decreases again. → Nightside/Dayside and Latitude/Longitude effects on the global scale variation are minor. Influence of the solar flux → N2 mixing ratio and density increase with periods of intense solar flux. → CH4 density increases with periods of intense solar flux, but proportionally less than N2. N2 → Isotope ratio 14N/15N = 197 ± 1.3 constant over the years. → Mixing ratio decreases when altitude increase. → molecular density changes with time. Figure 3: Nitrogen density (cm-3) as a function of altitude and time. The gray line is the solar F10.7 cm flux in solar flux units. N2 molecular density (cm-3) Vernal equinox 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 Figure 2: Mixing ratios of Nitrogen, Methane, Argon and Hydrogen as a function of time and altitude. Vernal equinox 9.03 AU Increasing Saturn-Sun distance 10.04 AU Figure 1: 100000 simulations of gases mixing ratio results for flyby T126 at each altitude (low to high altitudes represented as a colour variation from yellow to blue). Figure 4: Mixing ratios of Nitrogen for flyby T27, T43, T59, and T83 used in our analysis. The gray area represents the altitude of the homopause graphically determined. Figure 5: Homopause altitude as a function of time. →Homompause altitude globally decreases over the years. → The altitude variations of the homopause follow the mixing ratio variations between each flyby. How to determine
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` ESA space debris studies: hypervelocity impact sample Photo Published on Twitter 12/4/21 Recent Experiments by European Space Agency Highlight Importance of Hydrocode Modeling PISALE simulations of off-normal impact of steel projectile on Al capture full 3D affects ABSTRACT: The solution of partial differential equations (PDEs) on modern HPC platforms is essential to the continued success of research and modeling for a wide variety of areas, especially groundwater flow and transport modeling in Pacific islands. The project implements an innovative combination of advanced mathematical techniques of Arbitrary Lagrangian Eulerian (ALE) methods with Adaptive Mesh Refinement (AMR), including parallel software tools to dynamically adapt the grids and special Lagrangian-flow methods that allow for the simulation of complex regional groundwater flow with dynamic freshwater and seawater interaction in heterogeneous volcanic rocks. The PISALE (Pacific Island Structured-AMR with ALE) software aims at a publicly available sustainable branch of the software and will provide accurate and scalable simulations of complex groundwater flow processes in the Hawaiian islands. The status of our ongoing project will be presented with student involvement, course development, and future plans. Other applications of PISALE are discussed as well. Student Involvement, Broader Impact, and Future Plans Course Development UH CEE 696-003 “Advanced Modeling in Groundwater Engineering” was offered in Fall 2022. The course delivered the concept/theory of ALE-AMR with a few PISALE applications. Future Plans • Flow module will be added and coupled with solute transport equations • The accuracy and scalability for island-scale freshwater-seawater interaction application will be tested Groundwater Flow and Transport Application in Hawaiian Aquifers Preliminary Results Motivation Kona, HI from NSF ‘Ike Wai project Rotzoll et al., 2010 Groundwater is the major source for public supply in Hawaiʻi. Groundwater resources exist as freshwater lens floated on top of seawater. However, groundwater availability is limited by recharge/precipitation and seawater intrusion. Current drought conditions and future sea level rise will impact the freshwater resources in Hawaiʻi. The PISALE project will support island-scale numerical simulation of density-driven flow and transport : 1. to evaluate groundwater availability 2. to design sustainable water use planning 3. to understand the effect of climate change and sea level rise on island water resources Mathematical Model for Density-Driven Flow Groundwater Flow head h(ρ), velocity v (LLNL’s MFEM) Salt Transport c(v) Methodology Flow and Transport with Heterogeneous Hydraulic Conductivity Field t = 0 [yr] t = 12.6 [yr] t = 25.2 [yr] PI Koniges hosted a PISALE workshop for researchers from U of Minnesota during ICCFD11 (left). Outreach efforts on Maui where PI Koniges and colleagues show current and old HPC hardware to local students (Right) Additional and Proposed PISALE Applications Seeded by NSF Funding • As a direct result of our NSF CSSI funded project we now have new application areas using the PISALE Framework: ALE (Arbitrary Lagrangian Eulerian) dynamics and structured AMR (Adaptive Mesh Refinement) Experiment Workshop & Outreach: Acknowledgement We would like to thank many additional members of the PISALE team. The PISALE code applications are supported by the National Science Foundation, under Office of Advanced Cyber Infrastructure Award Number 2005259, the U.S. Department of Energy, Office of Science, under Fusion Energy Sciences Research Division Award Number DE-SC0021374, and the Office of Naval Research, under ONR MURI Award Number N00014- 20-1-2682. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility located at Lawrence Berkeley National Laboratory, operated under Contract No. DE-AC02-05CH11231 using NERSC awar
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RESEARCH POSTER PRESENTATION DESIGN © 2019 www.PosterPresentations.com Project Description To: Project Framework Methodology Anticipated Results University of Pretoria, u17367311@tuks.co.za Tendai Mataranyika SA Universities Institutional Repositories Publications Mapping and UNSDGs Classification Nexus Open Repositories Conference 2023, Cape Town, South Africa Research Output Clustering OpenAIRE Repository Data Sources SDG Classification Service This project still in its early stages seeks to map Institutional Repositories of selected South African universities through clustering and classification using the SDG classification service. This mapping will provide insight on which SDG research themes have been worked on by which universities. Information derived from this project will feed other research consuming communities and policy makers interested in understanding how Higher education contribute to development initiatives.
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Use of barcoding, from theory to practice (PRACTIBAR) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 207 000 Picture 1 Picture 1 Picture 1 Goals The main goal of the project is to raise awareness on barcoding as a generic method for pest identification and to train experts of the competent organisations, as highlighted at the end of the Euphresco project and as recommended by the EPPO Panel on Diagnostics and Quality Assurance in 2016-01- 19/21. Workshops and proficiency tests (PT) will be organised and training material developed. Research consortium EPPO (INT), AGES (AT), ILVO (BE), CFIA (CA), AU (DK), ANSES (FR), JKI (DE), SASA (GB), VAAD (LV), NVWA (NL), INIAV (PT), APHIS (US), UG (CA), FA (RS) Contact information Project coordinator: Françoise Petter fp@eppo.int Baldissera Giovani bg@eppo.int Objectives and key outputs Workshops will be organised in the framework of the project that will allow participants to be informed of the most recent advancements on the method and to receive training on a number of tools for data analysis: sequencing analysis softwares that allow assembly of raw sequence data (e.g. Geneious), online databases (Q- bank, NCBI, BOLD). Raw sequence data will cover examples from arthropods, bacteria, fungi, invasive plants, nematodes, phytoplasmas, viruses and viroids, depending on the needs and wishes of the workshops’ participants. A proficiency test will be organised at the conclusion of the workshops to determine the performance of individual laboratories. 05/2017-04/2019
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Chair of Waste Processing Technology and Waste Management (AVAW) Department of Environmental and Energy Process Engineering Montanuniversität Leoben (MUL) Franz-Josef-Strasse 18, 8700 Leoben, Austria E-Mail: avaw@unileoben.ac.at, Homepage: avaw.unileoben.ac.at DTU Sustain Department of Environmental and Resource Engineering Danmarks Tekniske Universitet (DTU) Bygningstorvet, Building 115, 2800 Kgs. Lyngby, Denmark Homepage: sustain.dtu.dk/en/om-os Consumers confused: Where to throw the compostable plastic? Namrata Mhaddolkar (MUL & DTU), Alexia Tischberger-Aldrian (MUL) The project C-PlaNeT has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska Curie grant agreement No. 859885. Background: • Starting 1st January 2020, plastic bags were banned in Austria; except for biodegradable bags. • According to Austrian compost ordinance, certified compostable dustbin bags could be thrown along with the biowaste. • Waste sorting guidelines instruct: compostable plastic packaging & bags to be disposed in lightweight packaging or residual waste bin. Visual identification method: Research question: What kind of compostable plastics were found in the lightweight packaging, organic, & residual waste in Austria? Lightweight packaging waste: Residual waste: Obtaining samples: • 27 samples from reject material from plastic waste sorting facility. • Samples collected from falling conveyer belt. Items found: • Supermarket carrier bags (majority), packaging for carrots, packaging nets from wood-fibre for onions, and dustbin bags. • No PLA material was found. • Some bags without proper labelling were found. Organic waste: Obtaining samples : • 27 samples from input material to composting facility. • The compost pile was divided into three parts based on length, and samples were taken from each section. Items found: • Dustbin bags (majority), packaging for carrots, and supermarket carrier bags. • No PLA material was found. • Some bags without proper labelling were found. Obtaining samples : • 27 samples from input material to residual waste handling facility. • Samples collected via quartering method. Items found: • Supermarket carrier bags (majority), packaging nets from wood-fibre for onions, dustbin bags, and take-away food packaging from PLA material. • Some bags without proper labelling were found. References: • Altstoff Recycling Austria AG. (2022). PACKSTOFFE AUF BIOLOGISCHER BASIS [Press release]. Wien. https://www.ara.at/uploads/Dokumente/Info- Merkbl%C3%A4tter/ARA-IB-Packstoffe-auf-biologischer-Basis-2022.pdf • Verordnung des Bundesministers für Land- und Forstwirtschaft, Umwelt und Wasserwirtschaft über Qualitätsanforderungen an Komposte aus Abfällen (2001). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnorm en&Gesetzesnummer=20001486 • Federal Ministry Republic of Austria. (2020). Plastic bag ban in Austria as from 2020. Federal Ministry Republic of Austria - Climate Action, Environment, Energy, Mobility, Innovation and Technology. https://www.bmk.gv.at/en/topics/climate-environment/waste- resource-management/waste-prevention/plastic-bag.html • Sametinger, S. (2017). Entsorgung von Bioplastik. ichbinsoplastikfrei. https://www.ichbinsoplastikfrei.at/grosse-unsicherheit-bei-der- entsorgung-von-bioplastik/ • COMMUNICATION FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT, THE COUNCIL, THE EUROPEAN ECONOMIC AND SOCIAL COMMITTEE AND THE COMMITTEE OF THE REGIONS (2022). https://environment.ec.europa.eu/publications/communication-eu- policy-framework-biobased-biodegradable-and-compostable- plastics_en • Image Sources: www.european-bioplastics.org; www.tuv-at.be; www.dincertco.de; www.showsbee.com Namrata Mhaddolkar namrata.mhaddolkar@unileoben.ac.at; namha@dtu.dk Webseite: LinkedIn (Scan the QR Code) Conclusion: • Similar kinds of compostable plastics were found in all three waste streams, although the quantities differed. • Even with labeling, consumers found confused w
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Age-Associated Changes in Urothelium-Dependent ATP Release Advancing Understanding of Overactive Bladder Syndrome (OAB) Pathophysiology Ayse Gurpinar, Maxwell Roberts, Lisiane Meira, Patrizia Camelliti and Changhao Wu Department of Biochemistry, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH,UK Normal bladder function relies on release of ATP from the urothelium (epithelial lining of bladder) [1]. This ATP communicates the degree of bladder fullness to the central nervous system. As a key regulator of urinary bladder sensation, disturbed release of this ATP is believed to contribute to pathophysiology of OAB [1]. Introduction Documented Key Evidence Prevalence increase with age for both sexes [1] Affects 30% of people over 65 years worldwide [2] Costs the NHS nearly £2 billion every year [3] Patients exhibit increased stretch-induced urothelial ATP release [4] Patients exhibit increased urothelial secretion of neuropeptides associated with inflammation [4] Methodology Hypothesis: Inflammatory mediators can modulate urothelial function via specific pathways during bladder ageing, contributing to aetiology of OAB. Animal model: Young (12-33 weeks) and aged (>80weeks) male C57BL/6 wild type mice. 1. Longitudinal full-thickness tissue strips were prepared via microdissection and fixed within organ bath with continuous perfusion 2. Superfusate samples were collected at specific times and tested for ATP content via Luciferin-Luciferase assay 3. Interventions used: Substance P (SP: inflammatory neuropeptide), Interleukin- 1α (IL-1α: pro-inflammatory cytokine), Thapsigargin (TG: raises intracellular Ca2+) and Staurosporine (STS: Protein kinase C (PKC) inhibitor) Results  Aged bladders exhibit variations in some pathways  Inflammation (IL-1α and SP) can induce urothelial ATP release in both young and aged bladders  PKC signalling dysfunction (STS) can be associated with augmented ATP release in aged bladders  Aged bladders might be associated with dysregulation of intracellular Ca2+ (TG) for ATP release Conclusions 1. Silva-Ramos⁎, M., Silva⁎, I., Oliveira, O., Ferreira, S., Reis, M., Oliveira, J. and Correia-de-Sá, P., 2013. Overactive bladder syndrome: Evidence that urinary ATP is a dynamic biomarker of detrusor overactivity. Autonomic Neuroscience, 177(1), pp.21- 22. 2. Puckering, G., Walker, D., Xu, L., Congdon, P. and Gooch, K., 2019. The Prevalence and Forecast Prevalence of Overactive Bladder in the Medicare Population. Clinical Medicine Insights: Urology, 12, p.117956111984746. 3. Ganz ML, Smalarz AM, Krupski TL, Anger JT, Hu JC, Wittrup- Jensen KU, et al. Economic Costs of Overactive Bladder in the United Kingdom. Urology [Internet]. 2010 Mar [cited 2020 May 5];75(3):526–32, 532-18. 4. Nässel, D., Zandawala, M., Kawada, T. and Satake, H., 2019. Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic. Frontiers in Neuroscience, 13. References Acknowledgements This study is University of Surrey, NIH [1R01AG049321- 01A1] and BBSRC [BB/P004695/1] supported. All the experiments mentioned above fulfil the ethical requirements. Figure 2.Illustrates the experimental set up. The arrow indicates orientation of the tissue strip in the organ bath. Figure 1. Depicts OAB phenomena [1]. Young Wild Type Figure 3. Data are expressed as median±interquartile range and tested by Wilcoxon’s. (SP[n=10]: con - 8[5,19] SP - 11[7,27] *p<0.05, IL-1α[n=14]: con- 12[5,26] IL-1α- 14[6,43] **p≤0.01,TG[n=13]: con- 11[8,14] TG- 15[7,20] * p<0.05, STS[n=15]: con- 11[6,19] STS - 13[6,26] NS p>0.05). Aged Wild Type Figure 4. Data are expressed as median±interquartile range and tested by Wilcoxon’s. (SP[n=9]: con - 6[4,19] SP - 15[8,39] **p≤0.01, IL-1α[12]: con- 6[4,15] IL-1α- 18[4,31] *p<0.05,TG [n=11] con-12[4,15] TG-9[6,20] NS p>0.05, STS[n=14]: con- 7[4,10] STS- 12[6,14] *p≤0.05). SHAPING FUTURES : This is the first project to compare the effect of inflammation on ATP release in
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KARMA.edu 1 - :مقدمــــــــة توفرKarma. edu لإلرشاد األكاديمي مجموعة متنوعة من األساليب التعليمية والخدمات والموارد المقدمة للطالب في محاولة لمساعدتهم على تسريع تقدمهم في التعلم و اللحاق بأقرانهم و تلبية معايير التعلم في الجامعة . 2 - ـ ال رؤيــــــــــا : تمكين الطالب من أن يكونوا متعلمين نشطين ومسؤولين يستفيدون بشكل كامل من العديد من الفرص التي توفرها الجامعة في كل من البيئات األكاديمية والمشاركة المجتمعية . 3 - :المهـمــــــة من خالل الشراكات المهنية الداعمة والتعاونية مع ،الطالب يكرس المستشارون األكاديميون جهودهم لتعليم الطالب كيفية الوصول إلى المعلومات األساسية واكتساب المهارات الالزمة التخاذ قرارات مستنيرة تؤدي إلى تحقيق أهدافهم التعليمية والوظيفية والحياتية. 4 - :القيـــــم يلتزم المستشارون األكاديميون بتقديم خدمات استشارية عالية الجودة وشاملة تلبي االحتياجات الفريدة لكل ،طالب ويكرس طاقم اإلرشاد األكاديمي جهوده لتهيئة بيئة تدعم متطلبات الطالب. 5 - :األهــــــداف • دعم ثقة الط الب بأنفس هم ومساعدته م كذلك اكتشاف قدراته م وا مكانياته م الدراسية وتطوير مهاراتهم لل تكيف مع بيئته م الدراسية واالجتماعية والعلمية والتغلب على أية صعوبات قد تعترض مساره م الدراسي. • تنمية وتطوير مهارة التخطيط لدى الطلبة ليطبقوا الخطة الدراسية المالءمة والمناسبة لهم. • تنمية وتطوير قدرة الطلبة على تحديد أهدافهم واختيار التخصص الذي يتالءم وقدراتهم وميولهم. • تنمية مهارات تنظيم واستثمار الوقت.
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, Our infrastructure automates fitting, allowing force field science and driving innovation Open Force Field: Improving the accuracy and applicability of open molecular models OpenFF partners with industry to build accurate, pre-competitive force fields for general use OpenFF 2.0.0 (Sage) is a leading public small molecule force field OpenFF Toolkit Interchange External components BespokeFit Topology SMIRNOFF force field (.offxml) Chemical structure file(s) (SMILES, .PDB, .SDF, etc.) Plugins ForceField SMIRNOFF: Assign parameters directly to chemistry Use of industry-standard SMARTS/SMIRKS chemical perception greatly simplifies tooling for parameter assignment while solving issues with extensibility and flexibility Protein parameters Rosemary OpenFF-3.0.0 Sage OpenFF-2.2.0 Parsley OpenFF-1.2.0 Parsley OpenFF-1.3.0 Sage OpenFF-2.1.0 Water model and ion parameters Rosemary OpenFF-3.1.0 Neural network charges Automated chemical perception General polarisability General neural network force field Surrogate modelling Parsley OpenFF-1.1.0 Parsley OpenFF-1.0.0 First OpenFF force field Sage OpenFF-2.0.0 Re-trained van der Waals’ 2019 – 2022 2023 2024 Thyme OpenFF-4.0.0 Virtual sites and BCCs Alternate functional forms Jeffrey Wagner, Open Force Field ACADEMIC INDUSTRY AbbVie Amgen Bayer Cresset Eli Lilly Janssen John Chodera (MSKCC) Michael Gilson (UC San Diego) David Mobley (UC Irvine) Michael Shirts (CU Boulder) OpenEye Pfizer Redesign Roche Ventus Vertex … and others Affiliates Simon Boothroyd (Psivant) Chapin Cavender (UCSD) Connor Davel (CU Boulder) Danny Cole (Newcastle) Lorenzo D’Amore (Janssen) Dennis Della Corte (BYU) PROJECT STAFF Lily Wang - Science Lead Jeff Wagner - Technical Lead Matt Thompson - Software Scientist David Dotson - Software Scientist Alexandra McIsaac - Staff Scientist Brent Westbrook - Staff Scientist Josh Mitchell - Scientific Communicator James Eastwood - Project Manager Trevor Gokey (UCI) David Hahn (Janssen) Josh Horton (Newcastle) Tobias Hüfner (UCSD) Meghan Osato (UCI) Ben Pritchard (MolSSI) Willa Wang (UCSD) Jeffry Setiadi (UCSD) Lee-Ping Wang (UCD) Yuanqing Wang (NYU) Marcus Weider (MSKCC) Prototype now available (*not the most up-to-date model!) OpenFF NAGL will use ML models to rapidly assign partial charges, even to large molecules Fitting self-consistent parameters for proteins and small molecules Null model: trained with extra data, no additional parameters Specific model: trained with extra data with additional parameters Performance equivalent to Sage Profile shape mismatch Virtual sites are now a top priority for small molecule improvement HF/6-31G* Sage With virtual sites RMSD (A) length=1.469 A k=467.3 kcal/mol/A**2 The OpenFF community shares insights, experiences, code and workflows. More than a dozen industry partners participate. Contact: info@openforcefield.org The OpenFF Software Ecosystem Where we’ve been and where we’re going Software and standards in the OpenFF ecosystem How to join OpenFF as an industrial partner Gapsys et al. JCIM 2022 Boothroyd et al. JCTC 2023 D’Amore et al. JCIM 2022 2023 OpenFF Keynote The SMIRNOFF specification OpenFF-2.1.0 our most recent FF Notebook using NAGL prototype New wayfinding documentation
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I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 EMG-based decoding of motor tasks in amputees using a minimal set of EMG electrodes. F. Barberi* f.barberi@sant annapisa.it F. Aprigliano* f.aprigliano@san tannapisa.it E. Gruppioni° e.gruppioni@i nail.it A. Davalli° a.davalli@inail .it R. Sacchetti° r.sacchetti@in ail.it A. Mazzoni* a.mazzoni@sa ntannapisa.it S. Micera* s.micera@sant annapisa.it *The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa, Italy °INAIL Prosthesis Center Vigorso di Budrio (BO), Italy Abstract— Lower-limb powered prostheses have been widely studied and optimized over the years to help amputees improving their life quality and their walking performances during different motor tasks. Prostheses control can rely on various kinds of sensors, like inertial sensors and accelerometers. Among these, electromyographic (EMG) - control of powered prostheses seems to be a promising approach. In this study, we recorded EMG signals from four muscles (i.e. Adductor, Tensor Fasciae Latae, Rectus Femoris and Biceps Femoris) of the stump of thirteen transfemoral amputee patients while they were performing five motor tasks: ground level walking, stairs ascending, stairs descending, ramp ascending and ramp descending. Recorded signals were processed and the mean absolute value (MAV) was extracted over a 20ms moving window. Post-processed signals were then used as input of a Support Vector Machine-based algorithm to classify the motor tasks. The algorithm followed two steps of decoding of motor tasks, classifying ground level walking tasks first, and trying to identify stairs ascending, stairs descending, ramp ascending and ramp descending afterwards. Results showed that it was possible to identify motor tasks with one single muscle, with an accuracy ranging between 70% and 83%. Increasing the number of muscles used for the classification led to higher performances: combining EMG from three or four muscles resulted in performances above 90%. These results proved that it is possible to reliably decode motor tasks with a EMG-based algorithm relying on as little as three recording sites, ensuring a minimum discomfort of the system for the users. Keywords — EMG, classifier, prosthesis, decoder, lower limb I. INTRODUCTION Lower-limb amputees experience a general low confidence while using their prostheses, expecially during challenging motor tasks. This leads to a bad distribution of their weight and asymmetric walking patterns, increasing the chances of suffering from back pain and joint degeneration [1]. Prostheses differ in the degree of assistance that they provide to the users. Passive prostheses do not actively assist the users and are used just as a physical support. Semi-active prostheses provide assistance adapting the stiffness of their joints based on the gait modality. Powered prostheses actively participate in the movement, changing the position of the prosthetic joints based on the performed activity. The actuation of these prostheses can be based on information exctracted from sensors like gyroscopes, accelerometers, goniometers, electromyographic (EMG) electrodes etc [2]. Using EMG signals can allow high degrees of voluntary control of the prosthesis. EMG signals were widely used to control ankle-foot prostheses in transtibial amputees [3]. EMG-controlled powered knee prostheses is still an open challenge, and many studies investigated this kind of control by using both EMG signals alone or in combination with other sensors [4]. Many studies used high number of EMG electrodes [5]. This can be in some cases difficult to implement, depending on the type and length of the amputation. In this study, a new decoding algorithm was implemented and tested on electromyographic signals collected from 13 transfemoral amputees. We investigated which was the minimum number of EMG electrodes that could guarantee high performances of the classification algorithm while maintaining minimum discomfort i
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Oliver Hahn E-Mail: o.hahn@zbw.eu Steffen Lemke E-Mail: s.lemke@zbw.eu An Exploration of Scientific Press Releases in the Context of Altmetrics Address: Düsternbrooker Weg 120, 24105 Kiel, Germany Introduction Dataset & Methods Press releases are published by organizations to bring attention to achievements they have reached. In the scientific domain, for example research institutions, funders, and academic publishers make use of press releases to advertise newly published papers and particularly promising scientific results. For altmetrics research, which analyzes the presence of scientific objects in various public domains like for instance social media, news, or policy documents, so far press releases have been an almost unregarded albeit promising source of data (Bowman & Hassan, 2019). Also, previous studies have shown a strong association between a journal article receiving promotion in a press release and its later citations and altmetrics (Lemke, 2020), further warranting a precise look at this communication format’s characteristics. We set out to explore two large samples of science press releases to gain further insights on their contents, creators, and role in the communication of research. Our data consists of two samples of press releases published over one year between April 2016 and March 2017. Two randomly chosen subsamples of 100 press releases each were used for content analysis by two independent raters.  1,856 press releases from IDW-Online  average length of press release: 724 words Subjects Disciplines assigned to press releases by IDW -Online. Frequent occurrences: Biology (13.67%), Medicine (11.13%), Environment and Ecology (7.76%), Chemistry (6.57%), Physics (incl. Astronomy) (6.35%). Topics The 50 most frequent word stems in the titles of press releases. The Porter Stemming Algorithm was used. Content Analysis — Press Release Texts From each dataset, 100 random press releases were examined for mentions of… … or if they did not mention any specific study at all (No Research). … featured studies‘ Methods, … their Limitations, Content Analysis — Releasing Institutions Oliver Hahn & Steffen Lemke ZBW — Leibniz Information Centre for Economics  founded in 1996 by the American Association for the Advancement of Sciences  14,000+ registered journalists from 90+ countries (de Vrieze, 2018)  founded in 1995 by a coalition of press officers from German universities  8,000+ registered journalists (likely predominantly German-speaking) EurekAlert! IDW-Online Portals for publication of science news– and press releases.  26,358 press releases from EurekAlert!  average length of press release: 755 words EurekAlert! IDW-Online Disciplines based on Scopus subjects of 10,483 journal articles promoted in the press releases. Frequent occurrences: Life Sciences (13.95%), Health Sciences (12.79%), Medicine (12.59%), Biochemistry (9.27%), Genetics and Molecular Biology (9.27%), Physical Sciences (7.55%), Agricultural and Biological Sciences (5.20%). EurekAlert! & IDW-Online … the findings‘ immediate practical Implications, … other studies, researchers or institutions not directly involved in the featured study (References), EurekAlert! IDW-Online Conclusion & Future Work  Press releases on both EurekAlert! and IDW-Online are dominated by life sciences, followed by physical sciences; other subjects are rare  They frequently describe featured studies’ methodologies and often also practical implications, descriptions of limitations or references to other research are less typical  Structurally, press releases seem to be a comparatively homogeneous format of external science communication, e.g. compared to news articles  Regarding the institutions submitting press releases, our analysis suggests substantial differences between both platforms: while universities account for large shares of the submissions to both portals, EurekAlert! seems to be shaped more by publishers and journals, while IDW-Online features many c
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POŠKOZENÍ LANGERHANSOVÝCH OSTRŮVKŮ MIKROPORACÍ S siRNA A BEZ siRNA Tomšovská V. 1,4, Fábryová E.1,4, Leontovyč L.1, Plecitá-Hlavatá L.3, Holendová B.3, Špitálníková Veřtátová M.1, Girman P 2. Berková Z 1, Kříž J 2. 1Laboratoř Langerhansových ostrůvků, CEM, IKEM, Praha 2Centrum diabetologie, IKEM, Praha 3Laboratoř pro výzkum pankreatických ostrůvků, Fyziologický ústav AVČR, Praha 41.Lékařská fakulta, UK, Praha Úvod: Mikroporace je jednou z transfekčních metod využívajících elektrické pulzy. Lze ji použít pro zavedení nukleových kyselin (NK) do buněk. Pomocí krátkých elektrických pulzů se vytvoří mikropóry v buněčné membráně, kterými NK mohou vstoupit do buněk. Testovali jsme potenciální škodlivé účinky této metody pro transfekci siRNA do buněk Langerhansových ostrůvků (LO). Metody: Mikroporace je jednou z transfekčních metod využívajících elektrické pulzy. Lze ji použít pro zavedení nukleových kyselin (NK) do buněk. Pomocí krátkých elektrických pulzů se vytvoří mikropóry v buněčné membráně, kterými NK mohou vstoupit do buněk. Testovali jsme potenciální škodlivé účinky této metody pro transfekci siRNA do buněk Langerhansových ostrůvků (LO). Výsledky: Všechny provedené testy ukázaly neporušenou funkci beta buněk bez rozdílu mezi mikroporovanými a kontrolními LO. Schopnost uvolňování inzulinu během perifuzního testu a rychlost spotřeby kyslíku nebyly porušeny. Při použití fluorescenčního testu integrity membrán bylo procento mrtvých buněk v LO: 15,9 % u mikroporace s siRNA, 13,7 % u mikroporace a 10,6 % u kontroly. qRT-PCR analýza produkce zánětlivých faktorů rovněž neprokázala rozdíly mezi vzorky. Závěr: Mikroporace nepoškozuje Langerhansovy ostrůvky a zdá se být bezpečnou technikou pro transfekci siRNA do buněk Langerhansových ostrůvků. Podpořeno projektem Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Program EXCELES, ID: LX22NPO5104) – Financováno Evropskou unií – Next Generation EU. Podpořeno MZ ČR – RVO („Institut klinické a experimentální medicíny – IKEM, IČ 00023001“)
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Aidin Niamir and Joy Kumagai Senckenberg Society for Nature Research Rainer M. Krug University of Zurich IPBES goes FAIR & CARE! Data and Knowledge Management Policy Adapted For further enquiries on IPBES data and knowledge management policy contact tsu.data@ipbes.net Since December 2019, Senckenberg Society for Nature Research has hosted a technical support unit for data, which supports the task force on knowledge and data with matters relevant to data management at IPBES. Two years have passed since the Multidisciplinary Expert Panel and the Bureau of the Intergovernmental Science‐ Policy Platform on Biodiversity and Ecosystem Services (IPBES) approved the IPBES Data Management Policy. Since then, the policy has been implemented within the Platform and revised to explicitly include considerations of the handling of indigenous and local knowledge. Inclusivity and collective benefit as it relates to open science are now recognized as guiding principles in the policy. To inform implementation, the CARE principles for Indigenous Data Governance now compliments the FAIR principles for scientific data management and stewardship. With the inclusion of these concepts and responsibilities, the IPBES data management policy has been renamed to the IPBES data and knowledge management policy. The IPBES data and knowledge management policy aims to improve the accessibility of products, transparency of the underlying processes to create them, and the CAREful handling of Indigenous and local knowledge within IPBES. https://doi.org/10.5281/zenodo.3551078 Data and Information Management Plan Approved IPBES 3 January 2015 Knowledge and Data Task Force decides to draft a data management policy March 2019 Data Management Policy v 1.0 Approved 14th Meetings MEP/Bureau January 2020 Data Management Policy v 1.1 Approved 15th Meetings MEP/Bureau November 2020 Plenary takes note of Data Management Policy v 1.0 IPBES 8 June 2021 Data and Knowledge Management Policy draft v 2.0 Reviewed 17th Meetings MEP/Bureau November 2021 Data and Knowledge Management Policy v 2.0 Approved 18th Meetings MEP/Bureau February 2022 History of the policy Annexes of the policy 1. Definitions Glossary of the key terms used 2. Implementation Resources • Series of Technical Guidelines https://ict.ipbes.net/data‐ management/technical‐guidelines • Policy tutorials https://ipbes.net/dmp/tutorials • Delivery protocol of the assessment drafts https://doi.org/10.5281/zenodo.5509137 Grounded in: ACCESSIBILITY & OPEN‐SCIENCE • FAIR principles for scientific data management and stewardship https://www.go‐fair.org/fair‐principles • CARE principles of indigenous data governance https://www.gida‐global.org/care
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Measurement of the Neutron Total Cross section on Argon in Energy Range of 30-70 keV Jingbo Wang on behalf of the ARTIE collaboration University of California, Davis The Argon Resonant Transport Interaction Experiment (ARTIE) was recently performed at the Time-of-Flight neutron beam at Los Alamos National Laboratory (LANL). ARTIE makes a new measurement of the total cross-section of neutrons on natural argon between 30-70 keV. This measurement is crucial for the Deep Underground Neutrino Experiment (DUNE) as it determines the feasibility of the neutron-based detector calibration technique and provides a deeper understanding of signals and backgrounds for the low energy physics programs. Abstract Neutron Total Cross Section Summary Motivation This work is supported by the Department of Energy, Office of Science and the National Nuclear Security Administration Acknowledgements The Deep Underground Neutrino Experiment (DUNE) is an upcoming US-based international long-baseline experiment for neutrino science. Screen Shot 2020-06-10 at 11.04.11 AM Design of Liquid Argon Target References [1] http://www.dunescience.org [2] R.R Winters, et al., Phys. Rev. C 43 492 (1991) [3] https://lansce.lanl.gov DUNE is the future flagship experiment of the Department of Energy. It will send a neutrino beam from Fermilab in Illinois to Sanford Underground Research Facility in South Dakota [1] The neutron transport in liquid argon is important: 1. Detector calibration: Can we use an external pulsed neutron source to calibrate the far detector? Neutron capture signal could be used as a standard candle energy. 2. Neutron shielding: How much shielding material is needed for suppressing the neutron backgrounds in supernova and solar neutrino programs. 3. Neutrino Physics: Are nearby neutrons useful to achieve better energy resolution during the reconstruction of the supernova neutrinos? ENDF vs Previous Measurement The Lujan Center at the Los Alamos Neutron Science Center (LANSCE) Experimental Setup at LANL Energy [eV] 20000 40000 60000 80000 Cross-section [barn] 1 - 10 1 10 ENDF Ar-nat Winters ARTIE’s target density is 3.5 atoms/barn: blind to high cross sections but sensitive to low-cross sections at 30-70 keV • 168 cm long, 1” OD stainless steel tube • Sealed by Kapton foil windows allowing neutrons to go through • Dry-nitrogen gas-flow-caps used to prevent ice formation on Kapton windows • Liquid level monitored by video cameras and temperature sensors • Thermal insulation provided by Polyurethane foam Need good understanding of neutron total cross section in the range of 30-70 keV • The ENDF prediction of the neutron total cross section on natural argon is ∼0.01 barn at 57 keV, which disagrees with a previous measurement of ~0.1 barn [2]. • Previous Measurement by Winters: o Neutron Transmission Measurement 2.216-meter long gaseous target with a density of 0.211 atoms/barn o Not sensitive to low cross section at energy range of 30-70 keV Liquid Argon Target Foam Insulation Liquid Argon fill Dewar Liquid Argon vent Dewar Gas Cap Gas Flow Gas Flow Gas Cap • Neutron energy determined using the Time-of-Flight technique • The total cross section is measured through neutron transmission TOF neutron detector Vacuum pipe Vacuum pipe Liquid argon target Neutron beam 𝜎! = − " #∗ln 𝑇! = − ! "∗ln #"#$%"# #$%&$%$%& 𝜎!: total cross section at energy bin i 𝑛∗: effective column density of the target 𝑇": transmission coefficient at energy bin i 𝐶"#: 𝑇𝑜𝑡𝑎𝑙𝑛𝑒𝑢𝑡𝑟𝑜𝑛𝑐𝑜𝑢𝑛𝑡for target-in run 𝐵"#: Background count for target-in run 𝐶$%&: 𝑇𝑜𝑡𝑎𝑙𝑛𝑒𝑢𝑡𝑟𝑜𝑛𝑐𝑜𝑢𝑛𝑡for target-out run 𝐵$%&: Background count for target-out run • Neutron beam: Flight Path 13 at Lujan Center at the Los Alamos Neutron Science Center (LANSCE) [3] Proton Target Liquid Argon Target At 30 meter Li-glass Neutron Detector at 65 m Target area at FP13 Measurement Strategy Transmission Measurements: • “Target-out” run with the target tube flushed by gaseous argon • “Target-in” run with the target tube filled with
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1 2 3 4 5 6 7 8 9 10 0 2 4 6 8 C O Cu Intensity Energy (keV) Spec 1 Spec 2 Ag Eapp = 0V, tapp = 5 min 1 2 3 8 0 1 2 70 71 72 73 74 75 Ag S Cu Cu O Intensity (a.u) Energy (keV) C Low-power electrically-polarized nanoscale metallic surfaces composed of cupric salt and silver metal exhibited effective deactivation against a broad range of microbes. Six log reduction of five different bacteria – both gram-positive and gram-negative, was observed with electrically-polarized ENM devices. ENM devices were also effective against one viral particle and two medically-relevant fungi tested in the studies. In-situ hydrogen peroxide in micromolar concentration was produced through the oxygen reduction reaction mediated by cuprous ions. The electrochemical steady concentration of cuprous ions in molar concentration over ten days is key to a sustainable production of highly reactive hydroxyl radicals in the solution. These studies add a new toolbox to producing highly reactive oxygenated species by utilizing an external power battery to electrically-polarizing the nanoscale metallic films. 0 10 20 30 40 50 0.0 0.5 1.0 [AA]/[AA]o tapp (min) Control Ag, 0V Ag, 3V ENM, 0V ENM, 3V 350 400 450 500 550 600 0 100 200 300 non-ENM, Eapp= 0V 0 h 48 h 96 h 120 h Intensity (au) Wavelength (nm) 0 60 120 0 1 2 3 4 5 non-ENM 0V ENM 3V [OH.] nanomoles/cm2 tapp (hr) 0.0 0.1 5 10 15 0 8 16 24 32 ENM, 3V non-ENM, 0V Ag, 0V Ag, 3V [Cu(I)] M/cm2 tapp ( 1000 min) 𝐂𝐮+ Accelerated deactivation of broad-range microbes via in-situ generation of reactive oxygenated species M. Aswad Ali1a, Annie Y. Vargas-Lizarazo1a, Tyler Sons2, Michelle Garnett2, Jose Vargas2, Michael Olson3, Philip Jensik4, Scott Hamilton- Brehm2, Punit Kohli1 1Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, USA; 2Department of Microbiology, Southern Illinois University, Carbondale, Illinois 62901, USA; 3Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA; 4Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA; aEqual contributors Abstract Development of new strategies that are effective against a broad range of microbes is a crucial area of research because of dwindling new antibiotics and emergence of antibiotic-resistant microbes. Here, we report on implementing electrically-polarized nanoscale metallic coatings (ENM) that deactivate a broadband microbes including Gram-negative and Gram-positive bacteria with six log reduction, within five minutes of treatment. ENM devices were also effective in the deactivation of a virus and a fungus with high efficiency. Highly damaging in-situ reactive oxygenated species (ROS), including hydrogen peroxide and hydroxyl radicals, were produced by electrically-polarized metallic coatings. A sustainable micromolar ROS concentration was observed for about three days in ENM devices allowing effective antimicrobial surfaces for long-term usages. ENM represents a non-conventional tool providing a highly effective antimicrobial mode of deactivation through the production of highly damaging ROS to microbes. Fabrication of ENM Characterization Conclusion Acknowledgement Microbe Droplet on ENM Deactivation through ROS/Free radical mediated processes triggered by electrical polarization 2. Soaking in Cu2+ 3. Sputtering Ag O2, H2O 𝐞− 𝐂𝐮𝟐+ Battery ENM Method - Deactivation of Microbes by ENM Cu Ka1 & Ag La1 mix Results – Deactivation of Microbes 𝐂𝐮𝟐+/𝐂𝐮+couple mediates formation of ROS by ENM through 𝐂𝐮+diffusion into bulk SEM Mix Map and EDS Confirmation of the Species Present in ENM Water Static Contact Angle Measurements = 118o ± 8o AFM Determination of Thickness Ag Coating and Particle Size Distribution 20 µm 20 µm Non-homogeneity in the Junction of the Fibers-Two Electrode Equivalency Junction of overlapping fibers does not have Ag coating – Prevents shorting Spec 1 Spec
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This project has received funding from the Circular Bio-based Joint Undertaking (CBE JU) under the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101112581 APPROACH Waste Characterization and Selection Samples from various pulp and paper industr y processes and organic waste were analysed f or differe nt parameter s. Sampl es wi th t he m ost promising acidification results were selected for further analysis. Various physical and chemical pre-treatments were tested to enhance volatile fatty acid (VFA ) yield . Combinin g multipl e pre-treatment s d id not significantly improve the results. Fermentation tests assessed VFA production efficiency under different pH conditions. Th e predominan t VFA s include d acetic , propioni c, and butyric acids. PRELIMINARY RESULTS The project started in May 2023 and is funded by Circular Bio-Based Europe Joint Undertaking under G.A. No 101112581 . During the first year, significant progress was made in optimising the production of volatile fatty acids (VFAs) from the waste streams. The consortium focused on characterising and selecting suitable waste samples, optimising pre-treatment methods and conducting acidogenic fermentation tests. ELLIPSE project transforms industrial waste into valuable bioproducts by co-processing heterogeneous waste streams. This approach addresses waste from slaughterhouses, the pulp and paper industry, dairy industry sludge, and glycerol, converting them into polyhydroxyalkanoates (PHAs) and bio-based fertilisers (BBFs) for agricultural and personal care applications. INTRODUCTION Optimising fermentation parameters exploring downstream concentration techniques t o enhance VFA production and PHA quality Pilot scale trials that involve scaling up the lab trials to 1 cubic meter, using various mixtures o f dairy waste, bellygrass, and/or waste glycerin e, wi th t he a im to produ ce VFA-ri ch materi al for project partners to utilize. End of life alternative of validated products will be studied to confirm their recyclability an d biodegradability. NEXT STEPS Rafael Jiménez Lorenzo (rajimenez@aimplas.es), Pablo Ferrero (AIMPLAS); Stephen Nolan (Green Generation); Nicola Frison, Chiara Bastianelli (University of Verona); Marco de la Feld, Antonietta Pizza, Martina Calò (ENCO); Ana Lúcia Carolas, Bruno Sommer Ferreira (Biotrend), Patrizio Salice, Sara Guerrini (Novamont); Nydia Badillo, Kim van der Heul (Helian Polymers); Bernhard Drosg, Lisa Bauer, Richard Pummer (BEST Research); Lidia Garrote, Dolores Hidalgo (CARTIF); Laurens De Brauwer (BBEPP), Filip Miketa (BIO-MI) AUTHORS EFFICIENT AND NOVEL WASTE STREAMS CO- PROCESSING TO OBTAIN BIO-BASED SOLUTIONS FOR PACKAGING AND AGRICULTURAL SECTORS Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or CBE JU. Neither the European Union nor the CBE JU can be held responsible for them.
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Holocene sea level change drives different fates of two Asian horseshoe crab species Qian TANG1, Prashant SHINGATE2, Yusli WARDIATNO3, Akbar JOHN4, Boon Hui TAY2, Laura-Marie YAP5, Jasmin LIM5, Hor Yee TONG6, Karenne TUN6, Byrappa VENKATESH2, Frank RHEINDT1 1National University of Singapore, Singapore; 2Institute of Molecular and Cell Biology, Singapore; 3Institute Pertanian Bogor, Indonesia; 4International Islamic University Malaysia, Malaysia; 5Republic Polytechnic, Singapore; 6National Parks Board, Singapore Overlapping distribution range but different habitat preference Different genetic diversity as evolutionary response The coastal horseshoe crab Tachypleus gigas Study area Bintan, Indonesia Changi Beach, Singapore Preferred habitats: Mangroves, mudflats Preferred habitats: Sandy beaches The mangrove horseshoe crab Carcinoscorpius rotundicauda -0.1 0 0.1 Correlation coefficient Spatial autocorrelation analysis (GenAlEx3) within 200km: CR disperses within 35km TG disperses beyond study area PCA plot: Spatial-genetic correlation in CR Panmixia in TG ADMIXTURE4 bar plots: Subdivision along the SS in CR F coefficient: Relatively low genetic diversity in CR, especially ones at south of SS Effective population size (LinkNe5) over Holocene indicates: Sea level rise and maintain at high level disconnection among habitats CR decline Rapid sea level rise coastal area increase TG increase Sea level maintain rapid mangrove formation in coastal area TG decline Conclusions Capability of population genomic analyses at small spatio-temporal scale may redirect conservation measures. Dispersal capability and habitat preference determine species’ evolutionary response to climate change. Further decline in CR with impending sea level rise, whereas TG may increase but subject to habitat dynamics and human disturbance. Methods ~300 individuals across the Singapore Strait (SS) Hundreds of thousand genomic SNPs using double-digest RADseq Dispersal capability was examined using spatial autocorrelation and resistance mapping. Genetic diversity was examined by calculating heterozygosity and effective population size CR hereafter TG hereafter 35km Upper and lower 95% confidence limits of null spatial structure models are illustrated with red dash lines. Mapping of resistance to dispersal (DResD2) indicates depth- limited dispersal of CR No significant resistance to dispersal of TG (data not displayed) References 1. Sekiguchi (1988). Biology of horseshoe crabs. 2. Keis et al. (2013). Journal of Biogeography 40, 915-927. 3. Smouse & Peakall (1999). Heredity 82, 561-573. 4. Giri et al. (2011). Global Ecology and Biogeography 20, 154-159. 5. Hollenbeck et al. (2016). Heredity 117, 207-216. 6. Bird et al. (2010). Geology 38, 803-806. Introduction Two of four extant horseshoe crab species, widely distributed across Southeast Asia1 Ecological & commercial values Conservation status is still under evaluation Sea level fluctuation (dashed line) and carbon isotope composition (dotted line) in the Singapore Strait during the Holocene6. Mangrove distribution4 is illustrated as blackish coastal areas. Acknowledgement This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Marine Science Research and Development programme (Award No. MSRDP-P19). Field work is supported by the Ah Meng Memorial Conservation Fund. CR CR CR TG TG TG Both Different dispersal capability
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SFA & IRD - 40 years of research partnerships J. Lebranchu, C. Violette, L. Dagorn, P. Guillotreau (IRD/MARBEC) I. Context IRD’s principal mission is to generate science centred on the intertropical and Mediterranean zone and founded on equitable scientific partnership with the higher education and research commu- nities (ESR) of the countries and regions concerned. This mission has a dual purpose: • Contributing to advances in scientific knowledge in matters of sustainable development • Helping to give development policies a better grounding in science. IRD is present in Seychelles since 1980 (Port of Victo- ria in 1982 in front of the three of four French purse seiner). IRD has structured his research around SDG imple- mentation and Seychelles priorities, especially on preserving biodiversity and sustainable management of ocean resources. IRD has been working on different domains: - the history of Seychelles (published in 1983), - a botanical inventory of the Seychelles' flora in the 1980s and a book published in 2014 - but IRD has mainly worked on fisheries and their impacts in collaboration with SFA (i.e "The Seychelles's blue gold", 2014). An overview of some studies are presented below. II. Fisheries studies A. FADIO (2003 - 2006) - 10 partners (IRD, SFA,…) from 6 countries i. FADIO (2003 - 2006) - 10 partners (IRD, SFA,…) from 6 countries FADIO (Fish Aggregating Devices as instrumented Observatories of pelagic ecosys- tems) is a project funded by the EU with two mains goals : - Objective 1: Development of prototypes: new electronic tags and instrumented buoys to observe fish aggregations around FADS - Objective 2: Improving knowledge on on pelagic fish around FADs Three main achievements: • Contributed to the development and successfully tested the first satellite-linked acoustic re- ceiver (listening station) that allows remote, real-time monitoring of open ocean fish implanted with sonic transmitters • Obtained first scientific descriptions of the species that comprise the community of animals associated with drifting FADs. • Obtained first measurements of residence times and swimming depths of tuna and other pelagic fish around drifting FADs. Estimated the orientation distance of dolphinfish on FADs using an experimental approach. B. MADE (2008 - 2012) - 13 partners (IRD, SFA,…) from 8 countries ii. MADE (2008 - 2012) - 13 partners (IRD, SFA,…) from 8 countries MADE (Mitigating ADverse Ecological impacts of open ocean fisheries) aims at proposing mea- sures: • To reduce by-catch of sharks and juvenile swordfish by pelagic longliners. • To reduce by-catch of sharks and turtles, and juvenile tunas by tuna purse seiners. • To assess the effects of FADs on fish ecology (to assess how much the release of FADs modi- fies the habitat and affects the ecology of fish). The project follows a multidisciplinary and integrated approach to achieve its objectives: • Behavioural studies, electronic tags (pop-up archival and acoustic tags) on sharks, juvenile swordfish and tuna. • Biological studies, trophodynamism, growth of sharks. • Socio-economical studies, economic efficiency indicators.  FOCUS: Results to reduce the shark mortality • Two independent methods have shown the extent of the issue of entanglement of sharks in nets of FADs in the Indian Ocean ==> future design of FADs should not have any netting • Guide of good practices to reduce the mortality of sharks and rays III. Data management for pelagic fisheries (from 1984) During the 1980s and 1990s, IRD and SFA scientists have developed different fisheries monitoring systems in Seychelles. Since 2000, IRD and SFA have collaborated to develop a shared informa- tion system focused on large pelagic monitoring. Figure 1: Example of collected data and associated data flow IV. Biology studies IRD and SFA have conducted many studies to better understand the biology and the food web of the pelagic species, like in 2014 with the EMOTION project on tuna reproductive cycle. Figure 2: Female tuna reproductive
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MeerKAT follow-up of enigmatic GLEAM 4Jy sources Precious K. Sejake Collaborators: Sarah V White, Ian Heywood, Kshitij Thorat, Hertzog L Bester, Sphesihle Makhathini and Bernie Fanaroff ●Identified host galaxies for 98 sources, thanks to MeerKAT sensitivity and high resolution (~7“). ●MeerKAT images reveal various morphologies (i.e., compact ‘single’ morphology, typical symmetric lobes (i.e, ‘double’ and ‘triple’ morphology), head-tail, wide-angle tailed (WAT), X-shaped morphology and complex morphology). ●This work has illustrated the importance of a telescope's angular resolution and sensitivity for morphological classification and host-galaxy cross-identification of radio sources at low frequencies. The high-resolution images from MeerKAT has allowed us to resolve ambiguous host-galaxy identifications and enigmatic radio morphologies of the MeerKAT-2019 subset, evident in NVSS/SUMSS (45”) and/or TGSS (25”) images. Conclusion Active Galactic Nuclei (AGN) are compact luminous regions at the centre of their host galaxy. The emission from the AGN are thought to be driven by the accretion of material onto a SMBH at the centre and in some cases may result in the production of relativistic radio jets. AGN activity has been shown to significantly impact the host galaxy by suppressing or promoting star formation; however, this is still a point of contention. Morganti et al. (2013) demonstrated that star formation might be suppressed whereby the radio jets expel gas from the system. Meanwhile, Croft et al. (2006) showed that the jets might trigger the collapse of the molecular gas and promote star formation. In order to gain a better understanding of which of these scenarios is more significant, a large sample of AGN with powerful relativistic radio jets is needed to provide robust statistics on the features of these AGN. White et al., (2020a, 2020b) defined such a sample, named the GLEAM 4-Jy (G4Jy) Sample. However, poor resolution archival data (at 25 to 45 arcsec - TGSS, NVSS/SUMSS) limited the host galaxy identification of 140 G4Jy sources (which we refer to as the MeerKAT-2019 subset), as these sources had unclear, complex morphologies (see the figure on the left below). The primary aim of this work is to use the high-resolution images from MeerKAT (~7” resolution) to disentangle the morphology and identify the likely host galaxy of these sources. Introduction Method - Visual inspection Results ●The Square Kilometre Array (SKA)-Mid precursor telescope ●64 Antennas that are 13.5 m in diameter ●Maximum baseline of 8 km About 10% of the sources in the G4Jy Sample have a larger positional offset (|R.A.| > 10′′, |Dec.| > 10′′; sources outside the square cyan region), while What’s next? Obtain redshifts from SALT spectroscopic data MeerKAT Create and inspect overlays Determine the morphology Determine the host galaxy GLEAM (~2’ resolution, 200 MHz) NVSS (45” resolution, 1400 MHz, Dec > -40o), SUMSS (45” resolution, 843 MHz, Dec < -40o) TGSS (25” resolution, 150 MHz) MeerKAT (~7” resolution, 1300 MHz) WISE W1 band (3.4 µm) An overlay of G4Jy 917. The radio contours are from GLEAM, NVSS, TGSS, and new contours from MeerKAT, overlaid on the inverted greyscale WISE (3.4 μm) image. Shown in the bottom left corner is the beam size for each survey; GLEAM, NVSS, TGSS, and MeerKAT. The cyan hexagon indicates the brightness-weighted centroid position, the green crosses ‘x’ signs are the AllWISE positions within 3 arcmin from the centroid position, and the white ‘ + ’ sign is the AllWISE position for the corresponding host galaxy for this source. Clear structures seen in MeerKAT (~7 arcsec), not seen in TGSS (25 arcsec) and NVSS (45 arcsec) ●Sejake et al., (2023) (https://ui.adsabs.harvard.edu/abs/2023MNRAS.518.4290S/abstract) G4Jy 665 resolved into two unrelated sources An example of a G4Jy source with complex morphology at 25 to 45 “ the majority of the sources (57%) in the MeerKAT-2019 subset populate this outer region.We expect to have this larger po
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XPTSeb (PTSub) [mol %] WPTSeb (PTSub) [wt.%] Tg [°C] E [Mpa] σb [Mpa] εb [%] PTF - - 58 2460 ± 376 79,10 ± 3,10 2,99 ± 0,17 PTF-PTSeb 95/5 5 6.1 46 290 ± 64 12,30 ± 0,23 247,02 ± 32,65 PTF-PTSeb 85/15 15 17.9 28 574 ± 79 17,15 ± 0,88 410,09 ± 18,27 PTF-PTSeb 75/25 25 29.16 12 2534 ± 176 76,49 ± 2,05 3,04 ± 0,27 PTF-PTSub 95/5 5 5.4 48 4113 ± 289 73,69 ± 3,70 2,39 ± 0,18 PTF-PTSub 85/15 15 15.9 31 2312 ± 52 16,71 ± 0,99 309,93 ± 50,80 PTF-PTSub 75/25 25 27.0 15 213 ± 82 70,61 ± 19,86 665,41 ± 46,08 SHAPE MEMORY BEHAVIOR OF FULLY BIO-BASED AROMATIC-ALIPHATIC COPOLYESTERS Agata ZUBKIEWICZa, Anna SZYMCZYKa, Sandra PASZKIEWICZb, Izabela IRSKAb [a] Department of Technical Physics, West Pomeranian University of Technology, Piastów Av. 48, 70311 Szczecin, Poland [b] Department of Materials Technology, West Pomeranian University of Technology, Piastów Av. 48, 70311 Szczecin, Poland Introduction Over the last decade, development of bio-based polymers has become one of the principal focuses of research in materials science, which is related to environmental awareness over gradual exhaustion of non-renewable resources. 2,5-furandicarboxylic acid (FDCA) stands out as a highly potential bio-based monomer able to replace petro-derived terephthalic acid.[1] FDCA and its derivatives can be used, among others, to obtain copolymers with interesting properties, such as shape memory effect. Shape-memory polymers as stimuli-responsive shape-changing polymers are of great interest for fundamental research and technological innovation. It is known that shape memory materials display the ability of changing their shape in response to external stimuli, such as changes in temperature.[2] In the present study poly(trimetylene 2,5-furanoate-co-trimethylene sebacate) copolymers (PTF-co-PTSeb) and poly(trimetylene 2,5-furanoate-co trimethylene suberate) copolymers (PTF-co-PTSub) containing from 5 to 25 mol % of trimethylene sebacate unis (TSeb), or trimethylene suberate units (TSub) were synthesized by a two-stage melt polycondensation process using dimethyl esters of 2,5-furandicarboxylic acid (DMFDCA), bio-1,3-propanediol (1,3-PD) and dimethyl sebacate (DMSeb) or dimethyl suberate (DMSub), depending on the copolymer. Fig. 3 a) Shape memory cycles of PTF-co-PTSeb 85/15 b) Shape fixity and shape recovery changes vs. cycle number Fig. 4 a) Shape memory cycles of PTF-co-PTSub 75/25 copolymer b) Shape fixity and shape recovery changes vs. cycle number 80% 81% 82% 83% 97% 98% 99% 100% 0 5 Shape fixity Shape recovery Cycle number 91% 92% 92% 93% 93% 94% 94% 95% 95% 94% 95% 96% 97% 98% 99% 100% 0 2 4 6 8 Shape fixity Shape recovery Ccle number Table 1. Characteristic of PTF-co-PTSeb and PTF-co-PTSub copolymers Fig. 2 Demonstration of shape recovery of sample (dumbbell) of PTF-co- PTSeb 85/15 copolymer at temperature above Tg. Conclusions The obtained copolymers were studied concerning their thermal properties and mechanical performance. By increasing the PTSeb or PTSub segment contents, the PTF-co-PTSeb(PTSub) copolymers show lower glass transition temperatures. One can also find that the mechanical properties are closely related to the ratio of PTF to PTSeb(PTSub) content in the copolymer. Additionally, the thermally induced shape memory effect was investigated, using DMTA analysis. In the case of shape-memory polymers (SMPs), the recovery time to original shape after regeneration depends on the temperature. It is known that SMPs at temperatures higher than Tg become rubbery and have a low Young's modulus and high formability. In this region, the shape of the SMP can be modified, and the modified shape can be kept if the temperature drops below the Tg. If the SMP is reheated above the Tg, the transition into the rubbery regime causes the SMP to regain its original shape. The PTF-co-PTSeb 85/15 and PTF-co-PTSub 75/25 copolymers showed satisfactory shape-fixity of over 91% and 80% , respectively, and shape recovery efficiency of over 95% and 98%, respectively. The
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detection of the full extent (1kpc!) of tidal tail of the Hyades star cluster and the first even detection of substructures in the tail of open star cluster putting constraints on the MW potential CHECK ALSO WANG, JERABKOVA (A&A, 2021) AND STAY TUNED - MUCH MORE IS COMING! JERABKOVA ET AL. (A&A, 2021) JERABKOVA ET AL. (A&A, 2021) See our ESA press release ALL STAR-CLUSTERS ALL STAR-CLUSTERS HAVE TIDAL TAILS HAVE TIDAL TAILS TEREZA JERABKOVA (ESA) - HENRI BOFFIN (ESO) - GIACOMO BECCARI (ESO) - LONG WANG (U TOKYO) - TIMO PRUSTI (ESA) PETAR + GAIA PROJECT We use N-body simulations to robustly identify tidal tails of open star clusters in the MW disc Star cluster With Gaia eDR3, we can search for tidal tails of open star clusters in the MW disk for the first time. AND WE ABSOLUTELY SHOULD DO THAT! AND WE ABSOLUTELY SHOULD DO THAT! PROBLEM? PROBLEM? Tidal tails do not co-move with their star-cluster and are hidden in the Galactic field Tidal tail Tidal tail tell us the tale of cluster formation tell us the tale of cluster formation and evolution and evolution and of the Milky Way potential that and of the Milky Way potential that has impacted the stars has impacted the stars TIDAL TAILS TIDAL TAILS Get in touch! Tereza.Jerabkova@esa.int
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Wrong Sign Contamination in NOvA Abhilash Yallappa Dombara (Syracuse University) for NOvA collaboration • NOvA is an off-axis (14.6 mrad), long baseline (810 km) neutrino oscillation experiment which uses NuMI beam at Fermilab. NOνA experiment Wrong Sign contamination Analysis procedure • The wrong sign fraction is estimated for electron neutrinos and muon neutrinos separately. • CNN (Convolutional Neural Network) was trained on simulation to identify neutrino and antineutrino events and validated with data. • A optimal cut value was chosen for Wrong Sign CNN ID based on efficiency and purity to separate the whole sample into wrong sign and right sign enhanced regions. • Compute the wrong sign fraction using matrix method 𝛼𝐵!" + 𝛽𝑆!# = 𝐷!# 𝛼𝐵$# + 𝛽𝑆$# = 𝐷$# 𝛼, 𝛽: Fit parameters D: Data S: Signal = 𝜈e , 𝜈μ CC and NC B: Background = $νe , $νμ CC and NC RS: Right sign enhanced WS: Wrong sign enhanced 𝑊𝑟𝑜𝑛𝑔𝑠𝑖𝑔𝑛𝑓𝑟𝑎𝑐𝑡𝑖𝑜𝑛= 𝛽(𝑆!" + 𝑆#") 𝛽𝑆!" + 𝑆#" + 𝛼( 𝐵!$ + 𝐵#") 𝑊𝑟𝑜𝑛𝑔𝑠𝑖𝑔𝑛𝑒𝑟𝑟𝑜𝑟= 𝐶%%(𝑆!" + 𝑆#")% (𝐷!$+𝐷#")% Matrix : 𝑀= 𝐵!" 𝑆!" 𝐵#" 𝑆#" Covariance matrix : C = 𝑀&' 𝜎(!" 0 0 𝜎(#" 𝑀) Analysis Results s Analysis Methods • Wrong sign contamination is fraction of neutrinos/antineutrinos in antineutrino/neutrino beam. • Wrong sign fraction is higher in antineutrino beam. • Wrong sign fraction affects our mass hierarchy and ẟcp. measurements because these parameters are estimated based on difference between 𝜈eand )νe appearance. • All possible wrong sign values for different universes of cross-section, beam and flux uncertainties is shown in blue histogram. Remaining systematics under investigation. • Currently used as data driven crosscheck but in future can be used for extrapolation. • Neutron capture method: Neutrinos are more likely to produce 𝜇% which gets absorbed in nucleus and produce delayed neutrons while antineutrinos don’t. • Prong CVN score: Identify neutrinos using a single particle classifier for proton identification • Wrong Sign CNN score: Dedicated CNN for classifying neutrinos and antineutrinos based on topological features • NOvA’s main goal is to use muon neutrino disappearance and electron neutrino appearance to probe neutrino mass ordering, ∆𝑚&' ' , q23 and dcp. • NOvA uses two functionally identical liquid scintillator detectors. 100 − 0 100 200 y (cm) 2200 2400 z (cm) 10 2 10 3 10 q (ADC) NOvA - FNAL E929 Run: 15330 / 4 Event: 11978 / -- UTC Fri May 23, 2014 17:30:2.632293184 Far Detector Data 5400 5600 500 600 700 y (cm) z (cm) 10 2 10 3 10 q (ADC) NOvA - FNAL E929 Run: 26110 / 49 Event: 3213 / -- UTC Sun May 7, 2017 04:41:20.910875840 Far Detector Data 0 5 10 15 Analysis bins 0 500 1000 1500 POT 20 Events / 11.09x10 NOvA Preliminary Beam n Wrong Sign enhanced Right Sign enhanced e n µ n e n µ n NC n NC n DATA High PID, 𝜈e selection 0.1 0.2 0.3 0.4 0.5 Wrong-sign fraction 0 200 400 600 Fake experiments Flux and cross- section systematic fake experiments Prong CVN Wrong Sign CNN NOvA Preliminary Beam n High PID, 𝜈e selection 0 0.05 0.1 0.15 Wrong-sign fraction 0 200 400 600 800 1000 1200 Fake experiments Flux and cross- section systematic fake experiments Wrong Sign CNN Neutron Capture Rate NOvA Preliminary Beam n 𝜈μ selection Neutrino Event Antineutrino Event 5 - 0 5 Background Uncertainty (%) Systematic Uncertainty Lepton Reconstruction Neutron Uncertainty Beam Flux Near-Far Uncor. Neutrino Cross Sections Detector Response Detector Calibration -beam n Selection e n NOvA Preliminary 0 0.2 0.4 0.6 0.8 Wrong Sign CNN 0 200 400 600 800 POT 20 Events / 11.6x10 NOvA Preliminary Beam n Data MC e n e n High PID, 𝜈e selection 2 - 0 2 Signal Uncertainty (%) Systematic Uncertainty Beam Flux Detector Calibration Lepton Reconstruction Detector Response Neutron Uncertainty Near-Far Uncor. Neutrino Cross Sections -beam n Selection e n NOvA Preliminary
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Fletcher et al. 2011 M51 Almost 100 nearby galaxies observed @ GHz (Beck & Wielebinsky 2013) Most recently these studies are extended to very low frequencies with LOFAR Adding a piece to the puzzle Dust polarization measurements in nearby galaxies to investigate magnetic fields in cold gas Rosita Paladino INAF IRA Bologna Italy Annie Hughes, Maud Galametz et al. host magnetic field whose structure has mostly been probed through polarimetric radio continuum observations @ cm wavelengths (synchrotron radiation and its polarization) Magnetic fields directly affect the mean gas density, which impacts significantly the star formation rate (Birnboim et al. 2015) They regulate Star Formation, both on the scale of individual stars and filaments and through the collapse and fragmentation of molecular clouds (Mac Low 2009; Crutcher 2012) Magnetic fields play an important role in launching galactic winds and outflows (Heesen et al. 2011) Nearby Galaxies To date, magnetic fields in external galaxies have been studied through synchrotron emission which do not probe the field’s properties in the cold gas component. ALMA’s unprecedented resolution and sensitivity in full polarization mode allows for the first time observations of dust polarization in Observations of magnetic fields in Nearby Galaxies are the most useful tool to provide constraints on the models, since unlike the Milky Way, the galactic environment and gas kinematic of star-forming regions can be well-characterized! In blue LOFAR emission Mulcahy et al 2018 NGC891 NGC 253 Magnetic fields influence structure and evolution of galaxies In the Milky Way, Planck polarization results show a poor correspondence between the polarization fraction and direction obtained from radio synchrotron and dust polarization measurements In regions where the effects of local structures dominate (Planck XIX, 2015) Dust Polarization data are important complement to radio observations. Both synchrotron and dust polarization trace the magnetic field component projected into the plane of the sky, but NGC253 is a nearby (3.5 Mpc) highly inclined (78°) starburst galaxy. Observed @ different wavelengths 0 An ideal target for pioneering extragalactic dust polarization observations. ALMA Band 7 data probe spatial scales between 5 and 50 pc, never accessed so far! Questions to possibly answer: What is the magnetic field direction at the foot of a galactic wind? How ordered is the magnetic field in the starburst region? Does the magnetic field at the disk-halo interface have a preferred orientation? Do GHz radio and dust polarization observations yield a consistent picture of the magnetic structure? Spatial resolution 6 pc Hughes et al. in prep Its prominent wind is powered by the intense star formation within a central zone of 300 pc diameter. Lobes and filamentary structures of Hα, radio synchrotron, X-ray and UV emission are observed up to several Kpc from the disk plane. Dust continuum at 353 GHz is extremely bright. On large scales radio polarization observations reveal a magnetic field in the disk that is parallel to the midplane and an X-shaped halo field centered on the nucleus. On the smallest scales (~150 pc), the magnetic field shows a vertical component aligned with the non-thermal radio filaments. Chyzy & Beck 2004 Antennae First dust polarization image of an external galaxy Heesen et al. 2011 Spatial resolution 150 pc their emissivities have different dependencies on the magnetic field strength. Planck XIX, 2015 Spatial resolution 3 pc Band 7 rms 15 μJy Very ongoing work!
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Mechanistic insights into the interactions between S. aureus amyloids and cell membranes L. Bonnecaze, K. Jumel, L. Khemtemourian, S. Lecomte, C. Feuillie, M. Molinari, M. Mathelié-Guinlet* Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, F-33600 Pessac, France S. aureus PSMs An opportunistic pathogen Antibiotic multiresistance PSMα3, an amyloid-like cytotoxic entity (f-)MEFVAKLFKFFKDLLGKFLGNN  Cross-α fibrillation Misunderstood interactions with both eukaryotic and bacterial membranes & Unknown influence of N-formylation, in toxic processes • Cytotoxicity F3A mutant No fibrillation reduced cytotoxicity but gained antibacterial activity f-WT thick clustered fibers f-F3A amorphous aggregates PSMα3 fibrillation [1] Peschel et Otto, Nat Rev Microbiol., 2013 [2] Tayeb-Fligelman et al., Science, 2017 [3] Malishev et al., J.Mol.Biol., 2018 *marion.mathelie-guinlet@u-bordeaux.fr [2] At 10 µM, both peptides induce only limited damage to PC-membranes f-F3A acts preferentially on bacterial membranes Impact of PSMα3 on biomimetic membranes Nanoscale visualization of PSMα3 membrane activity Accumulation and elongation of fibrils on PC-membranes, only on fluid phases Formation and propagation of a « front » and eventually holes around the growing fibrils On PE / PG membranes, peptides do not deposit nor disrupt the SLB No lipid-dependent changes in 2nd structure for both peptides high α-helical content conserved (>50%) DOPE/DOPG + f-WT / f-F3A 5µM 120’ 0’ 600nm T cells Gram + 0 20 40 60 80 100 Toxicity (%) WT F3A 1. Incubation 3days @ 37°C in buffer (ThT fluorescence) 2. Interactions with supported lipid bilayers (AFM & ATR-FTIR) • Inflammation • Biofilm Is toxicity driven by fibrils? Eukaryotic membranes PC vs. Bacterial membranes PE/PG Buffer : 10 mM sodium phosphate buffer + 150 mM NaCl, pH 8,0 SLB formed by SUV fusion Methods [2-3] [1] f At 5-10 µM, f-WT and f-F3A induce only small damage on eukaryotic membranes whereas f-F3A disrupts bacterial membranes 0 2 4 6 8 10 12 14 16 18 0 2 4 6 8 10 12 f-WT f-F3A Buffer ThT fluorescence intensity (x103) Time (h) 200nm 200nm 0 250 500 750 1000 -1.0 0.0 1.0 2.0 3.0 4.0 Distance (nm) Height (nm) 60’ 120’ 600nm DOPC DPPC 0’ DOPC/DPPC + f-WT 5µM 15’ 30’ 600nm 0 150 300 450 600 −0.5 0.0 0.5 1.0 1.5 Height (nm) Distance (nm) 200nm 200nm 0’ DOPC/SM/Chol + f-F3A 5µM 10nm 140MPa Elasticity Elasticity 1500 1550 1600 1650 1700 0.0 0.2 0.4 0.6 0.8 1.0 Absorbance (u.a.) Wavenumber (cm-1) f-WT spectrum Fit spectrum Turn Alpha Random // Beta DOPC DOPC/DPPC (1:1) DOPC/SM/Chol (67:8:25) DOPE/DOPG (1:1) 0.6 0.9 1.2 1.5 1.8 2.1 2.4 fWT10µM 3h fF3A 10µM 3h Dichroic ratio DOPC DOPC/DPPC (1:1) DOPC/SM/Chol (67:8:25) DOPE/DOPG (1:1) 0 20 40 60 80 100 120 140 Lipid coverage [p-pol] (%) + f-WT 10µM, 3h + f-F3A 10µM, 3h SLB Accumulation on membranes At high concentrations (50µM), f-WT disrupts PC-membranes while f-F3A rather destroys bacterial PE/PG ones. PC/SM/Chol PE/PG 0 20 40 60 80 100 Lipid coverage (%) + f-WT 50µM + f-F3A 50µM At the nanoscale, hydrophobic effects likely drive PSMα3 accumulation and fiber elongation at the membrane interface Funded by the European Union (EU). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the EU. Neither the EU nor the granting authority can be held responsible for them.
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Multi-Resolution Active Learning of Fourier Neural Operators Shibo Li 1, Xin Yu 1, Wei Xing 4, Robert M. Kirby 1,2, Akil Narayan 2,3, Shandian Zhe 1 1Kahlert School of Computing, University of Utah 1Kahlert School of Computing, University of Utah 2Scientific Computing and Imaging (SCI) Institute, University of Utah 3Department of Mathematics, University of Utah 4School of Mathematics and Statistics, University of Sheffield Abstract: Fourier Neural Operator (FNO) is a popular operator learning framework. It not only achieves the state-of-the-art performance in many tasks, but also is efficient in training and prediction. However, collecting training data for the FNO can be a costly bottleneck in practice, because it often demands expensive physical simulations. To overcome this problem, we propose Multi- Resolution Active learning of FNO (MRA-FNO), which can dynamically select the input functions and resolutions to lower the data cost as much as possible while optimizing the learning efficiency. Specifically, we propose a probabilistic multi-resolution FNO and use ensemble Monte-Carlo to develop an effective posterior inference algorithm. To conduct active learning, we maximize a utility-cost ratio as the acquisition function to acquire new examples and resolutions at each step. We use moment matching and the matrix determinant lemma to enable tractable, efficient utility computation. Furthermore, we develop a cost annealing framework to avoid over-penalizing high-resolution queries at the early stage. The over-penalization is severe when the cost difference is significant between the resolutions, which renders active learning often stuck at low-resolution queries and inferior performance. Our method overcomes this problem and applies to general multi-fidelity active learning and optimization problems. We have shown the advantage of our method in several benchmark operator learning tasks. Introduction & Motivation Physics vs. Machine Learning • Physics: Accurate, Principled, Extrapolate Well • Machine Learning: Flexible, Efficient Computational Physics: Finding the solutions of PDEs • Analytical solutions: closed forms but not always feasible • Numerical solutions: accurate, reliable but slow and no generalization Wave Fluid Dynamics Electromagnetism VS. Data-Driven Computational Physics • Learning PDE solutions directly from data • Efficient prediction and generalization Analytical Numerical (e.g., FEM) • Initial condition • Boundary condition • PDE coefficients Heat Equation PDE Solutions Neural Operators and Fourier Neural Operators • Solutions of PDEs are applying operators to the source/parameter/initial functions • Learning the parametric mapping between functions to functions Neural operator layer … Functional space transformation Function convolution Neural operator layer Convolutional Theorem Stationary kernel functions Fourier Neural Operators (FNO) Input function 1 … X Y Numerical Solvers Slow! Expensive! However, Data Costs for Training FNO!!! Input function 2 Input function N Solution1 … Solution 2 Solution N • Probabilistic Multi-Resolution FNO • Active Learning for FNO • Robust performance via cost-annealing Our Contributions Methods Probabilistic FNO FNO Ensemble 2 … Predictive distribution Monte-Carlo Ensembles … FNO Ensemble 1 FNO Ensemble M Multi-Resolution Active Learning FNO MR Utility Multi-Resolution PDE data Probabilistic MR FNO Ensembles Pool of MR data Numerical Solvers Multi-resolution acquisition function Step1: Monte-Carlo approximation Step 2 : Predictive distribution via moment matching Step 3 : Efficient computation via Weinstein- Aronszajn Identity Cost-Annealing Strategy for Robust Active Learning … Few Data Inferior model performance Inaccurate Utility Dynamically assign cost to each resolution Probabilistic Multi-Resolution FNO Experiments Evaluations of Multi-Resolution Active Learning Visualization of Pointwise Error after Active Learning (Navier-Stocks) Ablation Study 1 : Predictive perfor
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Soil-, management-, and climate-related drivers of yield stability in organic and conventional farming systems Hofer Simon1*, Hirte Juliane1, Mayer Jochen1, Jarosch Klaus A.1* 1Agroecology and Environment, Agroscope, 8046 Zurich, Switzerland; *[simon.hofer@agroscope.admin.ch | klaus.jarosch@agroscope.admin.ch] 1 Background Soils provide multiple ecosystem services that enable a continuous production of crops. Farming systems that promote ecosystem services are also expected to be mo- re resilient against external stressors, enabling a more stable crop production. To better understand the soil-, management- and climatic- related drivers of yield stabili- ty in different farming systems, the EJP SOIL ARTEMIS project is analysing different long-term field experiments across Europe on these parameters. Preliminary findings 1. Conventional farming systems have more stable yields during adverse climate conditions. 2. Fertilization-based differences in yield stability are more pronounced for organic farming systems. 3. Soybean yields are stable during adverse climate conditions and effect of farming systems are small. Next steps Include soil-related (fertilization, CN stock change) and management-related (plant protection, soil tillage) effects to find the most relevant drivers of yield stability. 2. Analysis of long-term data This study was conducted using data from the Swiss DOK long-term comparison trial, that continously compares dif- ferent typical farming systems since more than 45 years (Figure 1). To assess climate-related effects on yield stabi- lity, weather anomalies were characterized using both raw climatic data (total precipitation, mean temperature) and drought indices (n = 9, on a monthly basis) recorded by a meteorological station close to the experimental site. 4. Preliminary Results Figure 2 Climate-related effects on yield stability of organic and conventional farm- ing systems assessed through the probabilities of yield falling below the 70th percen- tile of the mean reference yield (RY) for potatoes, maize, soybean, and winter wheat. Chosen climate variables included standardized precipitation evapotranspiration index (SPEI), Palmer drought severity index (PDSI), and Palmer Z-Index, indicating different aspects of drought conditions Pr (y ≤ 70% of RY) Potatoes Pr ( y ≤ 70% of RY) Pr ( y ≤ 70% of RY) Crop-specific drought indicator Crop-specific drought indicator Crop-specific drought indicator Crop-specific drought indicator Maize Soybean Winterwheat 2 3 Pr ( y ≤ 70% of RY) Figure 1 DOK long term farming system comparison trial. The experimental design consists of eight different farming systems and fertilization intensities (half = 1; full = 2). Organic systems are characterized by fertilization through slightly (BIOORG) and fully (BIODYN) aerobically composted farmyard manure and slurry, and mechanical weed control. Conventional systems combine manure and mineral fertilization (CONFYM) and a system with only mineral fertilization (CONMIN2), and received chemical plant protection. 3. Production Risk Assessment We defined yield stability as the probability that the yield of the farming system i falls below the 70th percentile of the mean of a reference yield (here CONMIN2). This produc- tion risk assessment can be interpreted as the certainty (or risk) with which agronomists or farmer can predict the yield amount of their cropping systems. To assess crop-specific drought influences on yield, we first subset the monthly calculated climate variables per crop using only month during the average historical growing seasons. The resul- ting variables were then subjected to a principle compo- nent analysis to reduce multicollinearity. The principal component 1 was then used as a crop-specific drought indicator. Dry Wet Dry Wet
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The Magnetised Environments of Radiative-mode and Jet-mode AGN Shane P. O’Sullivan1, C. R. Purcell2, J. S. Farnes3, X. H. Sun2, C. S. Anderson2, B. M. Gaensler4, et al. Abstract: We present results from a broadband (1 to 10 GHz) radio polarisation analysis of 102 radio-loud AGN. We investigate the most likely mechanisms causing the observed differences in the integrated 1.4 GHz polarisation properties of radiative-mode and jet-mode AGN, as found in O’Sullivan et al. (2015). Our analysis shows that jet-mode sources with high integrated polarisation at 1.4 GHz have low RM dispersion, are dominated by a single polarised component, and have a steep spectral index. We find that while, on average, the radiative- mode AGN are in slightly more turbulent magnetised environments than the jet-mode AGN, it is mainly the intrinsically disordered magnetic field structures of the radiative-mode AGN that leads to the lower integrated polarisation seen at 1.4 GHz (O’Sullivan et al. 2016, in prep.). Results: There are ~40% of sources that have one dominant RM component, ~50% with two RM components and ~10% with three RM components. Therefore, in order to investigate the magnetised environments of all sources in a consistent manner we calculate the polarisation-weighted RM dispersion, σRM,wtd (eqn. 3). This provides a characterisation of the general amount of depolarisation in the local environment of each source. Figure 2b: Here we show a source with more complicated polarisation behaviour from 1 to 3 GHz, which is well fit by two complex-polarisation components. Interestingly, the high angular resolution data at 9 GHz show that the source is a double-lobed radio galaxy, which supports the results of our model-fitting. *Data from the Australia Telescope Compact Array (ATCA) References: O’Sullivan et al. (2012), MNRAS, 421, 3300 O’Sullivan et al. (2016), in prep. O’Sullivan et al. (2015), ApJ, 806, 83 Sokoloff et al. (1998), MNRAS, 299, 189 Summary & Future work: - Our study emphasises the necessity for broadband polarization observations to accurately determine the Faraday rotation measure properties of the integrated emission from radio-loud AGN. - The results show how we can distinguish between the intrinsic magnetic field properties of sources and the external magnetised environment that causes depolarisation, using our polarization model-fitting approach. - We find that the radiative-mode AGN are in more turbulent magnetised environments and have more intrinsically disordered magnetic field structures than the jet-mode AGN, on average. - Future all-sky radio polarisation surveys, with telescopes such as the Australian SKA Pathfinder (ASKAP) and the VLA, will provide much greater statistical power to investigate the detailed magnetic field properties of different classes of radio-loud AGN in different types of environments. Figure 3b: Here we see that all the highly polarized sources at 1.4 GHz are dominated by a single RM component (Blue circle: one component, Green diamond: Two components, Red triangle: Three components). The low degree of polarisation for sources with two or three RM components is possibly caused by interference between the components. Several, but not all, of the weakly polarised sources have flat spectral indices indicating that the polarised emission is likely emanating from a synchrotron-self-absorbed region, which limits the the intrinsic degree of polarisation to <~ 10%. The remaining optically-thin low-polarisation sources have intrinsically disordered magnetic field structures. Figure 3a: Here we plot the degree of polarisation at 1.4 GHz versus the polarisation-weighted RM dispersion for radiative-mode (blue) and jet-mode (red) AGN. There is a clear absence of sources with a high degree of polarisation at 1.4 GHz and high RM dispersions, suggesting the depolarisation caused by the magnetised environment local to the source is an important factor. However there are several sources with low RM dispersions that also
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Bridging the Gap between School Climate Policies and the Harsh Reality of Chicago Public Schools that Leads to Chronic Absenteeism Haniyyah Thomas, University of Illinois Chicago Dr. Joseph K. Hoereth, Institute for Policy and Civic Engagement, University of Illinois Chicago While observing a Chicago Public Schools (CPS) high school, I noticed how determined staff members were to improve ’on track’ rates. So, I asked them if there were any commonalities amongst students that were ’off track’, and it was quite simple— they didn’t come to school. I then learned 89% of the students were chronically absent, schoolwide, with 42% of 9th graders being off track to graduate in SY2023. The most prominent indicators of post-secondary enrollment are on-track status, Grade Point Average (GPA), and course failures. On-track status refers to whether a student has enough credit to graduate from one grade to the next, which the Illinois State Board of Education (ISBE) identifies as the completion of 10 semester credits. Since missing a day of school is a missed opportunity to learn, absence has a significant impact on student achievement. Chronic absenteeism, missing 10% or more days of school with or without excuse, is a national crisis (U.S. Dept. Ed., 2016). Truancy refers to unexcused absence for at least 5% of the school year. School climate refers to the character and experience of the school, and according to ISBE it is shaped by 4 components: safety, relationships, teaching & learning, and the institutional environment. Chicago Public School’s (CPS) Comprehensive Policy on Attendance serves to align all CPS schools’ with ISBE school codes and promote best practices pertaining to attendance. Article II specifically addresses the individual school’s responsibility in improving attendance and Section C requires all schools to implement an attendance plan that targets the underlying causes of chronic truancy. The policy does not address the vast discrepancies in school climate across CPS school districts, thus failing to provide proper resources and support to improve school climate for schools that are more likely to experience more adverse contributors to their school climate, such as schools with high populations of low- income students. Figure 1 shows that there is an increase in the number of students that are chronically absent in schools that have higher populations of low-income students. With that, there is also an increase in the variation as the enrollment of low-income students increases, which means that there is an unobservable factor that can reduce chronic absenteeism. While more advanced data analysis is required to explain the increase in variation, I hypothesize that school climate decreases the negative impact that poverty has on student attendance. Chicago’s Current Solution Something’s missing... What’s the big idea? This is important to know... Sources: WHAT’S THE BIG IDEA: Illinois State Board of Education, 2023 | THIS IS IMPORTANT TO KNOW: Illinois State Board of Education, 2024; U.S. Department of Education; 2016 | CHICAGO’S CURRENT SOLUTION: Chicago Public Schools, 2022 | SOMETHING’S MISSING: Illinois State Board of Education, 2024 | FINDINGS: UChicago Impact, 2023; Illinois State Board of Education, 2012, 2024 | FINDINGS CONT.: Illinois State Board of Education, 2024; Chicago Public Schools, 2022; Sample School, 2024 American Community Survey, 2022 (https://www.chicagosfoodbank.org/get-involved/learn/) Sample School Figure 1 Graph generated from Illinois Report Card, 2023 data The supportive environment indicator is the most dependent upon the school’s neighborhood characteristics. The variation, especially in schools with a low score, suggests that there are ways that schools can mitigate absenteeism irrespective of neighborhood quality. Illinois Report Card (ISBE) The Illinois Report Card, an annual publication by ISBE, offers an extensive dataset and interactive reports detailing the performance of individua
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RADICAL-Cybertools: Middleware Building Blocks NSF's Cyberinfrastructure Ecosystem (NSF 1931512) Motivation: Sophisticated and scalable workflows have become essential for advances in computational science. In spite of the many successes of workflow systems, there is an absence of a reasoning framework for end-users to determine which systems to use, when and why. Workflows are increasingly a manifestation of the algorithmic and methodological advances; workflow users and workflow system developers are often the same. Workflow systems must be easily extensible so as to support diverse functionality and the proverbial “last mile customization”. We advance the science of workflows and prevent workflow system “vendor lock-in” by formulating a building blocks approach to middleware for workflow systems, grounded on four design principles: self-sufficiency, interoperability, composability and extensibility. A building block has: (i) one or more modules implementing functionalities to operate on a set of explicitly defined entities; and (ii) two well-defined and stable interfaces, one for input and one for output. Properties of building blocks ●Self-sufficiency: design does not depend on the specificity of other building blocks ●Interoperability: can be used in diverse system architectures without semantic modifications ●Composability: its interfaces enable communication and coordination with other building blocks ●Extensibility: its functionalities and entities can be extended to support new requirements or capabilities The diagram below describes the primary functional requirements for workflow systems. RADICAL-Cybertools are designed as building blocks that span multiple functional levels: (L4) Workflow and Application Description: Requirements and semantics of applications and workflows. (L3) Workload Management System: Applications devoid of semantic context are expressed as workloads. (L2) Task Runtime System (TRS): Execution of the tasks of a workload. (L1) Resource Access Layer: Capabilities, availability and interfaces required by the tasks to be executed. Motivation: Middleware Building Block Primary Functional Levels RADICAL-SAGA (Simple API for Grid Applications): Provides an interoperability layer that lowers the complexity of using distributed infrastructure whilst enhancing sustainability of distributed appli- cations, services and tools, in the form of a Python API. By abstracting away the heterogeneity of the underlying systems, RADICAL-SAGA simplifies access to many distributed cyberinfrastructures such as XSEDE and OSG. (L1-L2) Interface to Resource ExTASY: Enables advanced sampling of complex macromolecules using molecular dynamics. DeepDriveX: Enables scalable and concurrent execution of Machine Learning (ML) and HPC workloads (X) on HPC Platforms. ICEBERG: Enables scalable image analysis on HPC. It allows the integration of image analysis frameworks and algorithms. SCALE-MS: Enables the concurrent execution of adaptive ensemble algorithms. It uses RADICAL-Pilot for workload execution. RADICAL-Cybertools support multiple points of integration, “unifying” conceptual reasoning across otherwise different tools and systems (L4) Workflow Management Systems Ensemble Toolkit (EnTK): Provides the ability to execute flexible combinations of ensemble-based workflows. It promotes “ensembles” to a first class abstraction, managing where and how the ensemble workload is executed. EnTK exposes a pipeline-stage-task programming model as the interface to express ensemble-based workflows. (L3-L4) Workflow / Workload Management SeisFlows ●Supports seismic inversion workflows on HPC machines, at scale ●We integrated SeisFlow: ○with RADICAL-SAGA (L1) to execute compute jobs ○with RADICAL-EnTK (L3) to orchestrate tasks and data staging ATLAS (Panda and Harvester) ●PanDA is a WMS that supports the execution of workflows via pilots ●We integrated Panda and RADICAL-Pilot to improve its scaling on large HPC resources, and integrated Har
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Anton Pirogov1 // Mustafa Soylu1 // Fiona D’Mello1 // Volker Hofmann1 // Stefan Sandfeld1 {a.pirogov, m.soylu, f.dmello, v.hofmann, s.sandfeld}@fz-juelich.de 1 Materials Data Science and Informatics (IAS-9), Forschungszentrum Jülich GmbH Metador: A metadata-centric framework for enabling FAIR research (meta)data handling Motivation development of high quality standards and software is difficult and slow bottom-up efforts often solve similar RDM problems with incompatible solutions Project Goals Metador will support scientists by: Current Status  operational container API and plugin system  prototype of schema and widget system  Metador dashboard integrated into InvenioRDM https://inveniosoftware.org/products/rdm Next Steps  Implementation of scientific pilot use case  Development of improved user-oriented tooling search for (meta)data of certain types, making datasets findable an ecosystem of reusable and generic software components JSON Schema and JSON-LD export, aligned with schema.org / ROCrate Metadata-driven automatic dashboards for data introspection Science needs better software tools Tools require (meta)data standards helping to organize research (meta)data facilitating bottom-up, pragmatic and incremental harmonization of schemas accelerating development of useful metadata-driven tools and services Interested? Get in touch! https://materials-data-science-and-informatics.github.io/metador-core Architecture of the Framework Metador = Plugin System + (Meta)data Packaging Format (Python ≥ 3.8) (entrypoint - based) (lightweight, domain-agnostic, extensible) + Metadata Schemas  based on pydantic  ensure strong validation  support field inheritance  JSON Schema export data + metadata Metador Container Other Domain-Agnostic Tools  technical: e.g. flask blueprint supporting dashboard integration in websites  user-oriented: tools to help with metadata(-schema) preparation, creation and management of Metador-enabled research data containers schema A research data metadata document preview widget schema B schema C schema D Metadata Harvesters  can be pipelined  extract metadata into schema-compliant objects  building block to support packaging automation (Interactive) Widgets  based on bokeh + panel  support Jupyter Notebooks  embeddable in a website  used for (semi-)automatic container dashboard  currently HDF5-based, designed for easy adaptability to common archive formats  simple h5py-based Python API provides advanced metadata management  all metadata objects conform to a schema and are stored alongside the data as JSON + + + Sketch of Planned Solution for the Pilot Use-Case Invenio visualize search find relevant data and inspect it { } JSON-LD JSON Schema export store / retrieve generic user-side tools (CLI/GUI) project metadata and schemas out into other formats and technologies manage containers using a state-of-the-art RDM repository software User Research Data Metadata Metador Container ‹ ?› ‹ ?› harvest validate metador-invenio Integration + Widget Plugins Generic Dashboard Schema Plugins pack export
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GERMAN FEDERAL INSTITUTE FOR RISK ASSESSMENT Federal Institute for Risk Assessment • Max-Dohrn-Str. 8-10 • 10589 Berlin, GERMANY • Phone + 49 30 - 184 12 - 0 • Fax + 49 30 - 184 12 – 99 0 99 • bfr@bfr.bund.de • www.bfr.bund.de Isolation and characterization of a novel mcr-5 carrying Escherichia coli plasmid from chicken feces in Germany Colistin is considered as an important antibiotic of the last resort against human infections with multidrug-resistant (MDR) Gram- negative bacteria. The emergence and spread of mobilizable colistin resistance in Enterobacteriaceae is associated with major public health concerns. Since 2015, several mobile colistin resistance genes were described coding for enzymes of the phosphoethanolamine-transferase family. Nowadays, eight different mcr-genes (mcr-1 to -8) were identified, mediating resistances to colistin in different bacterial genera (especially in Enterobacteriaceae). In this study, a novel mcr-5 carrying plasmid of a commensal E. coli recovered from chicken feces is described. Introduction Here we describe a novel mcr-5 plasmid-prototype from an E. coli isolate of the German national monitoring of zoonoses in food and livestock in 2013/2014. The isolate exhibited a MIC against colistin of 4 mg/L as determined by using broth microdilution according to the EUCAST guidelines. Basis genetic features of the Whole Genome Sequencing (WGS) analysis of the isolate are summarized in Table 1. S1-PFGE (Fig. 1) analysis and WGS revealed that the genome of the plasmid pEC1897-13 was 38 kb in size and exhibited 44 putative open reading frames (ORFs; Table 2), respectively. Basic properties of the E. coli isolate and its plasmid Transmissibility of the mcr-5 carrying plasmid K. Juraschek1,†, M. Borowiak1,†, D. Shamoun1, S. Schmoger1, A. Irrgang1, N. Pauly1, M. Grobbel1, A. Käsbohrer1,2, B. Malorny1 & J.A. Hammerl1 Bioinformatic analysis indicated that the plasmid belongs to the IncFII group, but represent a novel pMLST-allele that is closely relate to the allele FII-82. Beside mcr-5, no further resistance determinant was detected on the plasmid. Interestingly, the plasmid genome of pEC1897-13 obviously comprises all necessary components of a functional IncF conjugative- transfer system (Table 2). However, up to now no self-transmission of the plasmid was observed in E. coli by filter mating studies at 37°C under different conditions. Correspondence to Dr. Jens A. Hammerl, National Reference Laboratory for Antibiotic Resistance, Department of Biological Safety, German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany; E-mail: jens-andre.hammerl@bfr.bund.de Here we report on a novel IncFII mcr-5 carrying plasmid-prototype recovered from chicken feces in 2013. The impact of the plasmid for the transmission of colistin resistances in unknown. However, despite of most of the described mcr-5 carrying plasmids pEC1897-13 carry a complex IncF-like transfer system that may be potentially functional under some specific circumstances. Conclusion 1German Federal Institute for Risk Assessment, Department of Biological Safety, Berlin, Germany; 2Institute for Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria; † both author contributed equally to this work Isolate 13-AB01897 Year of isolation 2013 Source Chicken, feces Genome features Genome size (bp) 5,256,358 GC content (%) 50.44 Genes (total) 5,758 Genes (coding) 5,317 CDS (total) 5,653 CDS (coding) 5,317 RNA genes (total) 105 rRNAs (total) 5S, 16S, 23S 6, 7, 5 tRNAs 77 ncRNAs 10 Pseudo genes (total) 336 Aquired antimicrobial resistances Aminoglycoside aph(3'')-Ib (100%) aph(6)-Id (100%) aadA1 (100%) Beta-lactam blaTEM-1B (100%) Colistin mcr-5 (100%) MLS mph(B) (100%) Phenicol catA1 (99.85%) Sulphonamide sul1 (100%) sul2 (100%) Tetracycline tet(34) (84.75%, partial) tet(A) (100%) Trimethoprim dfrA1 (100%) Chromosomal point muations gyrA S83L PlasmidFinder (inc group) Col ColRNAI (91.74%, partial) Col(MG828)
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GaiaHub: Precise proper motions combining data from the Gaia and Hubble space telescopes Andrés del Pino (CEFCA, adelpino@cefca.es) We present GaiaHub, a publicly available tool1 that combines Gaia measurements with Hubble Space Telescope (HST) archival images to derive precise proper motions (PMs). GaiaHub yields considerably improved PM accuracy compared to Gaia-only measurements (up to 10 times better), especially for faint sources (G 18), requiring only a single epoch of HST data observed more than ~7 yr ago (before 2012). To illustrate the capabilities of GaiaHub, we ≳ apply it to samples of MW globular clusters (GCs) and classical dwarf spheroidal (dSph) satellite galaxies. This allows us to measure the velocity dispersions in the plane of the sky for objects out to and beyond 100 kpc. ∼ Results ●We find, on average, mild radial velocity anisotropy in GCs. ●We observe a correlation between the internal kinematics of the clusters and their ellipticity, with more isotropic clusters being, on average, more round. ●The Draco and Sculptor dSph appear to be radially anisotropic systems. Fig. 1: Comparison between the results obtained using Gaia and GaiaHub for the Palomar 4 GC (d☉ = 108.7 kpc). Left column: PMs in RA vs. Dec, measured by Gaia (top panel, red) and GaiaHub (bottom panel, blue). Right column: sky positions of the stars with the projected proper motion vectors. New PMs, not present in the Gaia DR3 catalog are shown by open blue squares. Member stars, are represented by large, darker markers. The improvement in the accuracy is reflected in the smaller dispersion of the results obtained with GaiaHub. Fig. 2: Summary of the results for the NGC 2419 GC (d☉ = 82.6 kpc) and the Fornax dSph galaxy (d☉ = 147 kpc) using GaiaHub and Gaia alone. From left to right the panels show the color-magnitude diagram, the PM uncertainties as a function of G mag, the PMs in RA vs. Dec (VPD) for Gaia DR3 (top, red) and GaiaHub (bottom, blue), and the footprint of the analyzed area showing the PMs as vectors (only GaiaHub measurements). Markers coincide with those of Fig. 1.. Stars whose PM uncertainty is below the central velocity dispersion, marked by an orange vertical dashed line in the second panel (measured through spectroscopy, 4.0±0.6 and 11.7±0.9 km s-1, respectively), are shown in dark blue. The gray shaded area in two leftmost panels indicates the region of saturation for the deepest HST images. In the third column of panels, the dark red open triangles from the top panel Gaia compare to the dark blue dots from the bottom panel (GaiaHub). Notice that newly measured PMs that are not in the Gaia catalog (light-blue open squares) are not present in the Gaia's VPD. 1. You can download GaiaHub from here: More information in the paper:
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Countering quarantine viruses and viroids through cleaning and disinfection (DISVIR) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 116 000 Picture 1 Picture 1 Picture 1 Goals Cleaning and disinfection of tools and greenhouse surfaces are recommended for official control of a number of viruses. However, a limited number of products are available, and efficacy evaluation data of such products are not always publicly available or consistent. The aim of the project is to improve the management of selected viruses and viroids. Research consortium CRA-W (BE), ILVO (BE), Fera (GB), Volcani (IL), IHPS (SI), APHIS (US), EPPO (Int), AHDB (GB) Contact information Project coordinator: Stephan Steyer and Kris De Jonghe s.steyer@cra.wallonie.be Kris.DeJonghe@ilvo.vlaanderen.be Key outputs and results The project will validate protocols for cleaning and disinfection against quarantine viruses and viroids. Results of this project could be considered to revise e.g. EPPO Standard PM 10/1 Disinfection procedures in potato production and EPPO Standard PM 9/13 Potato spindle tuber viroid on potato and contribute to the development of new PM 10 Standards. Objectives The project consortium will: • gather information on disinfectants and protocols for cleaning and disinfection (through literature review and exchange of knowledge among experts) • validate cleaning and disinfection protocols for selected pests, such as tomato brown rugose fruit virus or potato spindle tuber viroid The project will not focus on disinfection of soil and seeds. Instead, it should define optimal cleaning and disinfection of equipment and tools (including containers, trays, shoes, machineries), greenhouses surfaces (including irrigation systems) and the workers’ skin. The development of authorization dossiers for new disinfectants is not in the scope of the project. 09/2021-08/2023
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Aedes Science Gateway: A Machine-learning Based Mosquito Egg Counting System Lawrence Miao Department of Computer Science Rensselaer Polytechnic Institute Troy, NY USA miaol2@rpi.edu Adam Frederiksen Department of Computer Science University of South Carolina Columbia, SC USA apf1@email.sc.edu David Reddy Research Computing University of South Carolina Columbia, SC USA reddydp@mailbox.sc.edu Bob Doran Research Computing University of South Carolina Columbia, SC USA rdoran@mailbox.sc.edu Sarah Gunter Pediatrics-Tropical Medicine Baylor College of Medicine Houston, TX USA Sarah.Gunter@bcm.edu Melissa Nolan Public Health University of South Carolina Columbia, SC USA msnolan@mailbox.sc.edu Abstract Each year, approximately 400 million people are infected with an arboviral disease from the bite of an Aedes mosquito. Scientists have been using mosquito traps that allow for high throughput identification and counting of Aedes mosquito eggs for decision-making on insecticide spraying and abatement. Aedes project is an effort to automatically count the eggs in the trap paper images by computer vision and machine learning techniques. Such a task can be very challenging due to debris on paper, congested egg clusters, etc. To address these challenges, we developed a new method that can automatically and efficiently run in a light environment, e.g., a mobile phone. Specifically, given an egg paper image, we first apply adaptive thresholding to convert it to a binary image. Then egg contours are extracted, followed by patch cropping over each closed contour. These patches serve as the inputs to a new convolutional neural network (CNN) [1] based classifier. The CNN consists of a series of convolutional layers, ReLU layers, and max-pooling layers, followed by two fully connected layers. We classify the patches as single eggs, egg clusters, and debris. The final count is determined by the number of single egg patches and the number of eggs in each cluster. The number of eggs in a cluster is estimated by the area of the egg cluster dividing by that of the average single egg. We divide the patch set into 1440 in training and 160 in testing with augmentation. The classifier is trained using CrossEntropyLoss, Adam optimizer with the base learning rate as 15-4, and 20 epochs. We achieve 92% accuracy in testing, 1% lower than ResNet50 [2]. However, our model takes < 1 second to process one image on CPU, 100 times faster than ResNet50. Building as a science gateway, Aedes mainly consists of a web portal that allows scientists to study the eggs collaboratively online and a backend process that uses the developed DL model to batch process the egg counting. The web portal is implemented in React.js, Java Spring Boot, Postgre SQL, OpenCV.js, and ONNX.js. The backend service is implemented in Pytorch. The science gateway is supported by Jetstream 2 cluster. REFERENCES [1] A. Krizhevsky, I. Sutskever, and G. E. Hinton. Imagenet classification with deep convolutional neural networks. NIPS, pg1097–1105, 2012. [2] K. He, X. Zhang, S. Ren, and J. Sun. Deep residual learning for image recognition. arXiv preprint arXiv:1512.03385,2015. Presented at Gateways 2022, San Diego, USA, October 18–20, 2022. https://zenodo.org/communities/gateways2022/?page=1size=20
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An introduction and overview to the new SPNHC publication 'Best Practices in the Preservation and Management of Fluid-Persevered Biological Collections'. Mr Julian Carter1, Mr Dirk Neumann2,3, Mr John Simmons4 1Amgueddfa Cymru National Museum Wales (UK), Cardiff, United Kingdom, 2Staatliche Naturwissenschaftliche Sammlungen Bayerns, Zoologische Staatssammlung, , Munich, Germany, 3Leibniz Institute for the Analysis of Biodiversity Change, Centre of Natural History of the University of Hamburg (LIB-CeNak), Hamburg, Germany, 4Museologica, Bellefonte, USA BEST PRACTICES IN THE PRESERVATION AND MANAGEMENT OF FLUID-PRESERVED BIOLOGICAL COLLECTIONS is a newly published book that establishes effective and achievable standards for the maintenance and care fluid collections of different sizes. The best practice recommendations are holistic and take into account resource limitations for maintaining collections in stable condition. Additional recommendations are provided in three un-ranked categories that reflect the differences in institutional curation capacity, storage environment, collection size, laboratory facilities, frequency of specimen use, and available resources (e.g., budget, collection care staff) in major research collections vs. smaller regional collections. The development of these best practices began with a 2013 initiative funded by a Clothworkers Foundation grant directed by Chris Collins (NHM London) and were further refined in workshops at SPNHC conferences in Cardiff (2014), Berlin (2016), and Denver (2017); an experts meeting at the Smithsonian (2018) directed by by Catharine Hawks; and a symposium on the “Preservation of Natural History Wet Collections: Feedbacks and Prospects” (Paris 2018) organized by Sophie Cersoy, Julian Carter, Marc Herbin, Dirk Neumann, and Véronique Rouchon. Information and critical comments from these interactive meetings served as a framework to enhance our understanding of the care and conservation of fluid preserved objects and develop key questions and baselines for future research. This presentation will summarise the way this book has brought together current collective knowledge on the management and care of fluid preserved collections while also drawing attention to how much we still do not understand. This enables the community to more clearly identify and prioritise the collaborative research needed to further enhance our understanding of these valuable and unique collections.
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USING THE IMAGING FLOW CYTOBOT (IFCB) TO BETTER UNDERSTAND PARTICLE SIZE DISTRIBUTION AND BLOOM DYNAMICS IN CENTRAL CALIFORNIA. Kendra Hayashi and Raphael Kudela University of California, Santa Cruz, Santa Cruz, CA Introduction Imaging flow cytobots (IFCBs) are powerful tools for understanding bloom dynamics in marine and freshwater environments. In addition to autonomously generating high resolution images, particle size and volume are derived during image analysis and provide important components to assessing the ecology of aquatic systems. Particle size distribution (PSD) is critical for calculating radiative transfer and often drives trophic dynamics. Here we use PSD derived from estimated spherical diameter (ESD) calculated from IFCB images to assess IFCB performance and phytoplankton community dynamics at the Santa Cruz Wharf (SCW) and San Francisco Bay (SFB). IFCB settings and PSD Conclusions Universal PMT settings on IFCBs do not yield similar results; each instrument must be optimized for its deployment environment and specific data acquisition requirements. Over the 3 years analyzed, PSDs in SFB appeared to be stable and consistently follow a power law model, even in the central bay where ocean water and tidal mixing strongly influence the phytoplankton community. Variations from the global mean are associated with unusual events in a geographic location. Unlike SFB, the SCW PSDs are less consistent with a fair amount of daily variation complicating simple analyses of PSDs. SCW PSDs reflect an increase of dinoflagellates in the phytoplankton community documented in 2018 (Fisher et al. 2020) and continuing to the present. The dinoflagellate “signature” is seen at all levels of the data (from individual samples to global averages). IFCBs are being used more widely, with automated image classification lagging as the image libraries are being built and tested. PSDs could be a quick and easy way to assess phytoplankton community dynamics in novel locations as we wait for the classifiers to come online. They could also be used as a rapid QA/QC test to assess data quality of larger datasets. Literature Cited • Fisher et al. 2020. Return of the “age of dinoflagellates” in Monterey Bay: Drivers of dinoflagellate dominance examined using automated imaging flow cytometry and long- term time series analysis. Limnol. Oceanogr. 65: 2125-2141. • Reynolds et al. 2010. Measurements and characterization of particle size distributions in coastal waters. JGR. 115: C08024. • Zhou et al. 2022. _fdapace: Functional Data Analysis and Empirical Dynamics_. R package version 0.5.9, https://CRAN.R-project.org/package=fdapace. Acknowledgments Thank you to John Negrey and the Kudela Lab for comments, suggestions, and statistical analysis (JN). This work was supported by Cal-HABMAP which represents multiple organizations and partners who contribute to the operation and maintenance of the IFCB network. Core funding has been provided by NOAA, including the IOOS, ECOHAB, and MERHAB programs, NASA, California Sea Grant, California Ocean Protection Council, and numerous in-kind contributions from our partners and stakeholders. Initial purchase and development of the IFCBs was supported by NA16NMF4270263 (Saltonstall Kennedy) and NA14NOS0120148 (NOAA OTT). Results • IFCBs detected varying sizes of microspheres as expected based on the specifications of the instrument (Fig 1) • The IFCBs performed similarly to other particle imaging systems (Reynolds et al. 2010). • ESD measurements of the beads were different from the expected values but were consistent within any given size. • Two instruments sampling side by side with identical PMT values yielded different PSDs and phytoplankton communities (Fig 2). • Sensitive PMT settings increase the ESD range and detect higher numbers of smaller particles (Fig 2a). • PMT settings strongly influence the phytoplankton community structure (Fig 2b). Results SCW PSDs do not consistently follow a simple power law
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Searching for pulsars in the Small Magellanic Cloud Emma Carli +Lina Levin, Ben Stappers and the TRAPUM team Why? How? Discoveries! Rare: of ~3k pulsars discovered, 31 are extragalactic Galactic properties impact Neutron Star population If double NS discovery: update extragalactic NS merger rates FRBs and magnetars Tied-array beams: ~800 timeseries with high frequency resolution recorded simultaneously on multiple sources Immediate multibeam localisation to ~1" precision On-site search for single and binary pulsars Supernova Remnants MeerKAT beams MeerKAT image of SMC: Cotton et al. 2024 Danielle Futselaar 7 radio pulsars discovered and timed: known population doubled First three young pulsars discovered in this galaxy, all of which have glitched within 1.5 years, two in Pulsar Wind Nebulae See Carli et al. 2022, Carli et al. (submitted) Find out more: trapum.org E-mail me: emma.carli@manchester.ac.uk MeerKAT Murriyang Parkes CSIRO / Shaun Amy DEM S5 Supernova Remnant and Pulsar Wind Nebula 1'
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The Need For a Digital Preservation Community of Practice Every organisation dependant on digital materials has digital preservation needs Collaboration and connection are essential for success in digital preservation Cross-disciplinary forums allow both experienced individuals and organisations to exchange digital preservation best practice and advice Digital preservation and training needs to be more accessible in the Australasian region “I’m just beginning to get a grip on digital curation and preservation … The community of practice idea is an underutilised one. It means colleagues can learn together and access the same pool of expertise.” - Fiona Blackburn, AIATSIS “Auspreserves is an inclusive space for experts and beginners alike to work together to solve digital preservation problems.” - Elise Bradshaw, PROV Digital preservation is one of the most collaborative fields I’ve encountered in a long professional career, and Australasia Preserves is a vital mechanism for collaboration in this region.” - Prof. Ross Harvey Australasia Preserves Key Highlights Australasia Preserves helps build local and global relationships, enabling sharing of digital preservation knowledge and experience The Australasia Preserves community of practice is a group of people who share an interest in the field of digital preservation Being part of a community of practice provides opportunities to develop personally and professionally. Find Ali at IDCC20 to find out more about the Australasia Preserves community of practice or tweet us: AliIcecream JayeChats #AusPreserves Presenter: Ali Hayes-Brady, Monash University Co-Author: Jaye Weatherburn, The University of Melbourne @ @ A digital preservation community of practice for Australia, New Zealand, and the broader Australasian region. AUS PRESERVES CO-ORGANISERS: Jaye Weatherburn, The University of Melbourne; Matthew Burgess, State Library of New South Wales; Ali Hayes-Brady, Monash University; Rachel Tropea,The University of Melbourne; Carly Lenz, Archives New Zealand; Jan Hutar, Archives New Zealand; Lachlan Glanville, The University of Melbourne; Carey Garvie, National Archives of Australia; Elise Bradshaw, Public Record Office Victoria Australasia Preserves established at The University of Melbourne Mar- Apr Nov Feb Jun pt 1 Jun pt 2 Sept Feb Jul Online forum created and monthly online meetings begin State Library of New South Wales organises face-to- face meetings with lightning talks and a panel discussion. “Digital Preservation for All” face-to-face event hosted by the Australian Institute of Aboriginal and Torres Strait Islander Studies (AIATSIS) and supported by AARNet Australasia Preserves turns one at IDCC19 and hosts the first Digital Preservation Carpentry Workshop A monthly meetup co- organised by AIATSIS and the National Library of Australia for Australasia Preserves about Digital Curation in the Indigenous Data Network “Introduction to Automation for Archivists” a workshop created by Jarrod Harvey, an AusPreserves member, held for the first time Monthly meeting focussed on Digital Preservation Education in Australian and New Zealand Universities 2018 2019 AUSTRALASIA PRESERVES 2 YEARS ON Australasia Preserves Illustration by Matthew Burgess (CC BY-NC-SA 4.0), www.matthewburgess.net; Tagline by Lachlan Glanville
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The metrics for a code fragment № Name Description / Comment 1–62 Number of keywords: continue, for, new, switch, assert, synchronized, boolean, do, if, this, break, double, throw, byte, else, case, instanceof, return, transient, catch, int, short, try, char, final, finally, long, strictfp, float, super, while (total and average among lines of code for each) Represents the contents of the code fragment 63–64 Number of characters in the fragment (total and average among lines of code) Represents the size of the fragment 65 Number of lines in the fragment Represents the size of the fragment 66–67 Nesting area of the fragment (total and average among lines of code) Represents the complexity of the fragment 68–69 Number of characters in the enclosing method (total and average among lines of code) Represents the size of the enclosing method 70 Number of lines in the enclosing method Represents the size of the enclosing method 71–72 Nesting area of the enclosing method (total and average among lines of code) Represents the complexity of the enclosing method 73–74 Number of references to fields from the enclosing class (total and average among lines of code) Represents the coupling with the enclosing class through its fields. Important when copying from another class. 75–76 Number of calls of methods from the enclosing class (total and average among lines of code) Represents the coupling with the enclosing class through its methods. Important when copying from another class. 77–78 Coupling with the enclosing class (total and average among lines of code) The sum of the two metrics above
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PROF. BUJAR BAJCINOVCI © INTERACTIVE KINETIC ARCHITECTURE PROGRESSIVE DESIGN PRINCIPLES RESEARCH CENTRES AND LABORATORIES
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1Galter Health Sciences Library, Northwestern University 2Altmetric, 3Oregon Health & Science University, 4VIVO Introduction While there are projects and ongoing efforts to better understand the diverse roles that professionals take on when contributing to the scholarly ecosystem, it is clear that more work is needed to fully explore the area of contributorship roles. Several leaders in this area have proposed projects to define an informatics infrastructure that enables the collection and dissemination on contributor attribution data to various stakeholder audiences. Projects of that nature bring excitement and expectation, as we wait to see where they will take us and how greatly they will impact the scholarly ecosystem. Perhaps most important is the need to accomplish this work in an open, collaborative manner, leveraging data standards along the way to enable interoperability and integration with existing architectures. Methods Contribution Ontology Goals Discussion Working with FORCE11 Attribution of Work in the Scholarly Ecosystem Karen E. Gutzman1, Stacy Konkiel2, Marijane White3, Matthew Brush3, Violeta Ilik1, Mike Conlon4, Melissa Haendel3, Kristi L. Holmes1, FORCE11 Attribution Working Group, OpenVIVO Working Group As research is driven forward by technological advances, the composition and structure of the research team is also evolving. Professionals from a wide array of backgrounds contribute to scientific breakthroughs and discoveries, often in ways that are not easily recognizable using traditional measures of scholarly impact. Metrics and indicators that are limited to grants and publications often cause these diverse contributions to be overlooked and undervalued. The lack of adequate representation can affect large swaths of the current scholarly ecosystem, such as career advancement, financial incentives, funding acquisition, and scholarly recognition. In this project we have outlined a list of contributor roles identified by the Force 11 Attribution Working Group. Contributor roles from existing taxonomies were leveraged (CRediT) and further enhanced with more finely-­resolved contributor roles based on an in-­depth investigation of activities and outputs. We have also collated and reviewed existing efforts on scholarly contribution taxonomies to determine their unique aspects, and how they complement each other. We reviewed the landscape of taxonomies and systems in order to compare and contrast key types of contributions. We also considered the objectives needed to create a contributorship model that is robust enough to cover various fields of research, and specific enough to adequately describe contribution in a meaningful way. Relevant Projects and Groups • Review and summarize the objectives of the projects listed above to determine how much they overlap -­ can a core set of objectives, perhaps with extensions, be defined? • Review and summarize key types of scholarly products and the roles that people have in relation to them, resulting from the Force15 workshop and from other efforts, such as the NISO Alternative Metrics Working Group • Landscape review, comparing and contrasting key types of contributions across the different taxonomies/systems • Recommendations for publishers, IRs, research profiling systems to implement Projects: • Project CRediT • OpenRIF (VIVO-­ISF ontology) • PROV • Becker Model for Assessing Research Impact • Transitive Credit • Academic Careers Understood through Measurements and Norms (ACUMEN Project) • Scholarly Contributions and Roles Ontology (SCoRO) Groups: • Global Alliance for Genomics and Health (GA4GH) • National Information Standards Organization (NISO) FORCE16 submission form that contains “Project Role” field. Ontology available on Github: https://github.com/openrif/contribution-­ontology Brainstorming session on output types at the Contribution and Attribution in the Context of the Scholar workshop at Force2015, Oxford. Results We found there to be a diverse land
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art driven innovation for the purpose of good partnerships for a sustainable, just and inclusive future eveline wandl-vogt technologies & tools trends & mindset knowledge & skills values & purpose humanity centered SDGs as value drivers- for city making knowledge4 development the eveline.wandl-vogt@oeaw.ac.at 09_2022 @caissarl @arselectronica #k4h+ @oeaw #explorations4u templates by adioma.com open innovation research infrastructure © ewv 2017 | with e.g. ars electronica, km-a, CERN ideasquare, metalab (at) harvard & topothek.AT AERI k4h+ exploration space design thinking participation experimentation agile organisations knowledge 4 development partnership aiming to create, drive and implement the agenda knoweldge 4 develpoment and in doing so contribute to agen- da 2030 and the sustainable development goals SDGs envisioning Vienna 2030 toolkit We developed a toolkit to connect the SDGs with perceptions about digital futures. For this we prepared a three steps interaction around ques- tions of sustainability and prospective visions for 2030 in the context of a socially inclusive city of Vienna, with a participative methodology between a qualitative and quantitative ap- proach. The toolkit has been testted in various learning settings and is available online free of charge. open science sharing economy breakthrough technologies & humanitarian values ThePort humanitarian hackathon ThePort @ CERN „We combine creative minds from CERN and non- profit organisations in interdicsiplinary teams to work on humanitarian technology related benefits for society“ [ThePort Association / Website] selforganization artistic methods in the classroom & SDGs Classroom Multi-sensory Practices For Collaborative Liveable Worlds We created a reader to foster sustainable under- standing and collaborative parctices from a class- room perspective, as one of our results of being awarded the Citizen Science Award 2022. We offer easy to go scenarios for 10 up to date sonic me- thodologies against a background of biocultural diversity, as outlined in our awarded project „Our Planetary Garden“. Starting from the challenge of obesity, with USPs cultural knowledge, experience and values as well as brain stimulation and observation (EEG) we designed a meaningful APP with innovative learning features against the background of AI. Emergent Topographies of Vienna & Artificial Flora (at) Spatial AI Ecologies WeQ
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The Hard Part A data set could meet the 15 FAIR principles but still not satisfy data users. For users, findable and accessible are about interfaces but FAIR is not about interfaces. FAIR principles enable interfaces, but they do not design them. An organic or use-case based approach works best for designing useful data systems. User advisory groups work best when they advise on specific discovery or access issues around real science problems. Interdisciplinary use cases are less well developed and more challenging. They are often either very generic or extremely bespoke making them particularly challenging to address in a broadly useful way. Users don’t always know what they want until they see it. They are not always aware of what new technologies can do. Large Language Models and cloud- services show promise in making (big) data more discoverable and accessible, and potentially interoperable. Multiple NASA repositories are doing work in these areas, but they need to coordinate their efforts more to develop useful services that address those challenging interdisciplinary use cases. Metadata remain at the heart of FAIR and the services required by users. In interdisciplinary and interoperable use cases the relationships between concepts becomes critical. Verbs may be more important than nouns in information modelling and representation. FAIR Data at Scale to Enable Open Science Mark Parsons (0000-0002-7723-0950), Robert Downs (0000-0002-8595-5134), Samrawit Gebre (0000-0002-8963-4856), Lan Jian (0000-0002-6849-5527), Julie Imig (0000-0003-2025-3585), and Anne Raugh (0000-0002-8300-9443). AGU 2023 Fall Meeting, San Francisco, CA, USA, 2023-12-14. IN41B-0586. Making data FAIR is easy. Making users happy is hard. Making new, interdisciplinary users happy is really hard. Background “Data can be FAIR [Findable, Accessible, Interoperable, Reusable]1 or Open, both or neither. The greatest potential reuse comes when data are both FAIR and Open. So the goal is to align and harmonise FAIR and Open data policy.” Quote and figure from the mighty Sarah Jones 0000-0002-5094-7126 Through a survey, a couple webinars, and a 150-person workshop in September in Boulder CO, the NASA Science Mission Directorate (SMD) has been working to define what the FAIR Principles mean in alignment with its new Science Information Policy (SPD-41a).2 The “Easy” Part OK, maybe its not easy but FAIR is increasingly well- defined. NASA repositories were able to agree pretty quickly on what the 15 principles meant. Standards and specifications already exist that help meet the FAIR principles, they just need to be more consistently applied at an SMD level. Work is needed but it is defined, achievable work. A SMD Working Group is developing guidance for repositories. It will be easier for new data as we build processes that allow data to be “born FAIR”. Interoperable is the hardest part of FAIR, because its about semantics and relationships. It needs to start at the discipline level while also considering the broader level. See developing work in Earth Science by Ge Peng et al. at poster IN41B-0579. Please comment on our initial guidance “Worst is solving a general problem. Best to solve a specific problem and use that to fix the next specific problem.” - a NASA data user “There is no nominal example of what a repository does.” - a NASA repository manager FAIR Data Open Data increasing degrees increasing degrees The 15 FAIR principles are geared toward machine actionability, but the human users ultimately define what is FAIR in practice. FAIR logo by SangyaPundir. Background people and gear figure created by Ifanicon from Noun Project “Hard” “Easy” Next Steps • Complete a high-level, SMD-wide guidance document on “How to be FAIR”. • Build from that guidance to develop a SMD-wide, base-level, assessable FAIRness metric. • Collaborations are developing around cloud-services, LLMs, and metadata harmonization. • Next year’s workshop will focus on user engagement and a m
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Solar as a Solution Solar Photovoltaic panels (PV) are a way to convert solar radiation into usable DC electricity. Solar radiation is radiant energy emitted by the sun. Photons are tiny packets of energy that travel millions of miles to earth and eventually collide with our solar PV modules. When they strike the PV cells their energy excites the electrons, creating usable DC electricity. The Energy Research Team is applying these concepts at DCMS by installing a 3.6 kilowatt solar PV array. Once the panels were installed on the roof, they were connected to the AC units. While the AC units were already the highest efficiency available they still tripled DCMS’s energy usage. The main goals of our project were to make DCMS more energy efficient by offsetting the grid usage and to also, demonstrate living sustainability can easily become common. SMALL ISLAND RESILIENCY STUDY: Energy Matters at the Local Level Deep Creek, Eleuthera, The Bahamas Ruby Bagwyn, Matthew Brown, Cecilia Compton, Martine Lavelle, Everett Moore, Cecelia Pilgrim Advisors: Bryan Carroll & Sarah Emrich Conclusion: The Bahamas is too reliable on diesel. Small Island Developing States still exclude alternative forms of energy. The goal is to set out to demonstrate that these alternatives are not out of reach for SIDs. To recap what the Energy Research Team did at the Deep Creek Middle School is they performed an energy audit to educate students and staff the reality of real time energy use in their classrooms. Then a baseline checklist was created for which the school and other buildings can measure energy conservation and sustainability. Lastly they installed air conditioning paired with a 3 kW solar array to cool the classrooms and do so without burning fossil fuels. Renewable energy is a symbol of sustainability, one of the three defining pillars of The Island School. Using what students have learned about sustainability we want to capitalize on the semester’s work, to catalyze the community and the country. Many small changes lead to one massive change. If all SIDS can see that solar is viable option for diesel, if even on a small-scale, this message can be spread wide. The community is proud that both The Island School and DCMS have taken steps towards a more sustainable future, and in doing so, demonstrating to the students and community members there is another way forward by thinking globally and acting locally. Energy Investigation The Energy Research Team began the improvement of DCMS’s sustainability by getting a better picture of their energy usage before and after the air conditioning was installed (AC). First, the team analyzed historical energy bills from 2016. From analyzing this, it was concluded that each month, Room 1, 2 and 3 used approximately 350 kWh, 50 kWh and 125 kWh respectively, as can be seen on Graph 1. The team then started collaborating with the DCMS Grade 8 students to collect data for after the AC was installed. This allowed the students to get directly involved with the project and get a first hand look at the energy they’re consuming as a school. The students collected data from their school’s energy meter every day, which allowed the team to have a daily record of energy usage. After analyzing this data, it was concluded that after the AC was installed there was a drastic increase in energy usage, Room 1, 2 and 3 usage to approximately 40kWh, 25 kWh and 23 kWh respectively, as can be seen on Graph 2. Graph 1 shows the historical electrical bills compared to a bill post AC. This increase in energy usage was expected, due to the high energy demand of the air condition systems. However, the solar panel array that the team installed is designed specifically to offset this usage. Energy in the Bahamas The Bahamas is near totally reliant on imported foreign diesel (Bahamas National Energy Policy). Diesel is refined from crude oil, which is a naturally occurring mineral oil that can be refined into various fuels and other petroleum-
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AerosolsopticalpropertiesinTitan’s detachedhazelayerbeforetheequinox B. Seignovert1, P. Rannou1, P. Lavvas1, T. Cours1 and R.A. West2,1 1GSMA, UMR CNRS 6089, Université de Reims Champagne-Ardenne, France, 2JPL, California Institute of Technology, Pasadena, California, USA Contact: univ-reims@seignovert.fr Introduction First observed in the 80’s by Voyager 1 and 2 flybys [1, 2], Titan’s atmosphere presents a complex stratified succession of haze layers above the main haze. One of these layers, the Detached Haze Layer (DHL), presented a large extent at 350 km and could be seen all along the limb surrounding Titan between 90◦S up to 45◦N. Voyager 2 radial intensity scans at high phase angles [3] reveal an important depletion of the aerosol particle density below this layer. The arrivial of the Cassini spacecraft in the Saturnian System in 2004, was a unique opportunity to investigate the persistence of the DHL over time [4]. The Imaging Science Subsystem (ISS) instrument on board performs a continuous survey of the Titan’s atmosphere. In 2011, West et al. [5] confirm the persistence in time of the DHL at the equator at 500 km before the equinox followed by a collapse at 380 km in 2008. Recent observations confirmed its disappearance in 2012 and a new emergence is reported in early 2016 [6]. This seasonal cycle, predicted by previous Global Circulation Models (GCM) [7, 8, 9], tended to be confirmed by theses recent observations. In this study our purpose is to characterize the physical properties of the DHL and its latitudinal variability during the 2005-2007 period. Observations To determine the properties of the aerosols in the DHL, we made a survey over the ISS images taken with the Nar- row Angle Camera (NAC) before its collapse in 2008 [5]. We limit our analysis on the CL1-UV3 filter (λ=338 nm) where only the aerosols scatter and to minimize the mul- tiple scattering. Table 1: List of ISS NAC images used in CL1-UV3 filter ISS ID Date Phase Pix. Scale N1506288442 2005/09/24 145◦ 5.5 km N1506300441 2005/09/25 151◦ 5.5 km N1509304398 2005/10/29 155◦ 6.1 km N1521213736 2006/03/16 68◦ 7.3 km N1525327324 2006/05/03 147◦ 7.2 km N1540314950 2006/10/23 120◦ 5.7 km N1546223487 2006/12/31 66◦ 7.4 km N1551888681 2007/03/06 143◦ 7.9 km N1557908615 2007/05/15 25◦ 7.8 km N1557919415 2007/05/15 25◦ 8.2 km N1559282756 2007/05/31 20◦ 7.7 km N1562037403 2007/07/02 14◦ 7.8 km N1567440117 2007/09/02 20◦ 7.9 km N1570185840 2007/10/04 27◦ 7.3 km N1571476343 2007/10/19 80◦ 8.2 km Figure 1: (left) Overexposed and contrasted ISS NAC N1551888681. (right) Same image inverted with geo-reference grid, sub-spacecraft point (SC), Spice Kernels predicted center (SK) and photometric equator (PE). Vertical profile, altitude and light curve For each image the limb profiles are extracted by 5◦bins in latitude on the illuminated side of Titan and smooth with a moving average. The local maximum I/F corresponding to the DHL is located in altitude and intensity. The DHL presents a very high stability in altitude (500±8 km) for all latitude lower than 45◦N. The I/F light curve content information about the shape of the aerosols. 400 420 440 460 480 500 520 540 0.005 0.02 0.03 0.05 0.01 Altitude (km) I/F () ISS data Moving average profile Average box DHL peak Oct Jan 2006 Apr Jul Oct Jan 2007 Apr Jul Oct 90 ◦S 60 ◦S 30 ◦S 0 ◦ 30 ◦N 60 ◦N 450 465 465 480 495 495 495 495 495 510 510 510 510 450 460 470 480 490 500 510 DHL altitude (km) 0.001 0.01 0◦ 20◦ 40◦ 60◦ 80◦ 100◦ 120◦ 140◦ 160◦ 180◦ I/F () Phase angle () DHL peak Figure 2: (left) N1551888681 vertical profile between 0 to 5◦N. (middle) Altitude of the DHL as function of time and latitude. (right) Light curve on the local maximum I/F between 0 and 5◦N. Atmospheric and scattering model We consider that above the DHL, the atmosphere of Titan is optically thin and the incoming flux from the Sun is not significantly attenuated down to the DHL, then the output flux can be simply described as: I/F = ω · P(θ) 4 · 1 −e−τext with τext
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aRK Z arbeitsKreis RömischeKaiserZeit römische kochkunst Die Küche der römischen Zeit war sehr vielfältig und es gab große Unterschiede im Ernährungsverhalten. Die gesellschaftlichen Eliten legten Wert auf teure Weine und aufwändig zubereitete Speisen, die breiteren Bevölkerungsschichten waren hingegen auf einfachere Kost angewiesen. Neben zahlreichen Gerichten zum Backen, Braten und Kochen erfreuten sich Süßspeisen großer Beliebtheit. In fenicoptero Fenicopterum eliberas ... Adicies in mortarium piper, cuminum, coriandrum, laseris radicem, mentam, rutam, fricabis, suffundis acetum, adicies caryotam ... et inferes. Idem facies et in psittaco. Für Flamingo Rupfe den Flamingo ... Gib in einen Mörser Pfeffer, Kümmel, Koriander, Laserwurzel, Minze und Raute und zermahle es, gieße Essig hinzu, gib Datteln hinein ... und serviere. Dasselbe mache auch mit Papagei. Apicius, de re coquinaria (Über die Kochkunst) 6, 6, 1 J. André, Essen und Trinken im alten Rom (Stuttgart 2013) J. Meurers-Balke – T. Kaszab-Olschewski (Hrsg.), Grenzenlose Gaumenfreuden. Römische Küche in einer germanischen Provinz (Mainz 2010) R. Maier (Hrsg.), Apicius. De re coquinaria. Über die Kochkunst. Lateinisch-Deutsch. Übersetzung und Kommentar (Stuttgart 1991) vielfalt flamingo literaturhinweise Text und Layout: D. Hagmann – A. Langendorf – R. Weitlaner 2014 Abbildung: Obstarrangement mit gläserner Schale, Topf und Amphora Casa di Julia Felix, Pompeii 2. Pompeianischer Stil © Zenodot Verlagsgesellschaft mbH Druck: A. Sulzgruber, Institut für Klassische Archäologie, Universität Wien Plakat_1.indd 1 19.05.2014 14:22:22
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CRIRES+ at the Very Large Telescope Oered from ESO Period 108, starting 2021-10-01 with the following limitations: @alexislavail alexis.lavail@physics.uu.se Spectral grasp ~ 0.3 μm* *varies with wavelength Collecting power ⌀ 8 metres at VLT UT3 Melipal Expected RV precision 3 m/s Calibration sources UNe lamp Gas cells Fabry-Perot étalon Wavelength coverage Y J H K L M 0.95 μm 5.2 μm spectroscopy R >80000* (0.2" slit-width) R ~50000 (0.4" slit-width) Resolving power *nominally R ~100,000 for the 0.2" slit R>~80,000 was measured at commissioning. We investigate and try to mitigate this. only spectroscopy (no spectropolarimetry) In AO: natural guide star = target = guiding star no extended targets (only compact sources) No AO: target = guiding star The Call for Proposals is out! https://www.eso.org/sci/observing/phase1/p108/ Alexis Lavail1,2 & the CRIRES+ consortium 1. Uppsala University 2. The Swedish Collegium for Advanced Study More info at https://www.eso.org/sci/facilities/paranal/instruments/crires.html The proposal submission deadline is 12:00 CET on 2021-03-25 Online poster at: http://aalex.is/posters/cs20p5
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Mining in the Green and Digital Era European 4 EU demo cases 1 replication demo in South Africa 10 different raw materials including 4 CRMs 10 mines around Europe TWITTER: @MastermineEU LINKEDIN: MASTERMINE Project WEBSITE: www.mastermine-project.eu E-MAIL: mastermine.euproject@gmail.com
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TASKS RELATIONS ATRIUM WP7 end-user researchers workshops and trainings service and providers skills initiatives gaps usability training materials require connectedTo attend acquire increase teachAt identify improve use identify identify identify identify articulate coordinate contact KEY TERMS NETWORKING WORKSHOPS WP7 GOALS T7.3 The ATRIUM Curriculum General assessment of the skills require d for the active use of services provided by ATRIUM RIs (atten tion to the digital gap) Set of recommendations on topics and modalitie s of training materia ls available and to be developed as part of the ATRIUM Curriculum (T7.3) Assessment methods: desk research (build on previous work) surveys workshops feedback from the forums/training (T7.2) T7.2.1 The ATRIUM Researcher Forum: fostering two-way communication understanding researchers’ needs involving service improvement facilitating the use/reuse of services T7.2.2 The ATRIUM Mutual Learning Exercises (MLE) for providers: addressing (meta)data interoperability facing quality challenges sharing knowledge discussing best practices FitSM training Developing an integrated set of courses (hosted , maintained, and sustain ed on DARIAH-Campus) Embedding the description of ATRIUM services into the pedagogical narrativ e focused on cross-disciplinary digit al methods, wide-ranging competenc ies (FAIR, OS) & disciplinary-spec ific training requirements Maximising the potential of ATRIUM datasets , workflows, demonstrato rs & services to be used in educational settings Creating a robust framework for open peer review assessment o f different research outputs (da ta publications, training materia ls, software, exhibitions, interac tive visualisations, etc.) Contributing to maximise the quality and impact of Arts an d Humanities research in Euro pe in the context of initiatives s uch as CoARA Incentivising Arts and Humanities users t o follow the principl es of Open Science FOSTERING CROSS-DISCIPLINARY RESEARCH THROUGH TRAINING AND OPEN SCIENCE PROJECT GOAL Authors: Cezary Rosiński cezary.rosinski@ibl.waw.pl Tomasz Umerle tomasz.umerle@ibl.waw.pl T7.1 The ATRIUM Skillset Assessment SKILLS AND GAPS STRUCTURED LEARNING MAXIMIZE IMPACT Facilitating workshops and training sessions t o connect end-us er researchers with serv ice and data providers Transforming training materials into onlin e course curricula a nd organize formal and informal sessions Improving research outcomes by implementing a peer-revie w assessment framework for t he humanities and expand ing impact through exte rnal engagement Assessing skills essential for the arts an d humanities communi ty and identifying gaps in transfer T7.2 The ATRIUM Bridge T7.4 The ATRIUM Peer Review Framework ATRIUM's project goal is to advance frontier knowledge and facilitate access to leading research infrastructures in arts and humanitie s (DARIAH), archaeology (ARIADNE), languages (CLARIN), and scholar ly communication (OPERAS). The Work Package 7 (WP7) of the proj ect focuses on promoting interdisciplinary research through training and open science initiatives.
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Handreichung zu Video-Uploads auf Video-Plattformen Werden personenbezogene Daten verarbeitet? Sind die Verantwortlichen für die Datenverarbeitung bekannt und klar definiert? Welche Verarbeitungsgrundlage wurde gewählt? Sind die Vortragenden DSGVO- konform informiert? Sind die Rechte der Vortragenden vorgesehen bzw. berücksichtigt? Ist eine automatisierte Analyse des Videos mittels Machine Learning geplant? Befindet sich die Video-Plattform mit Sitz oder Speicherorten außerhalb der Europäischen Union? Personenbezogene Daten sind Daten mit Informationen über eine Person, über die eine Person auch identifiziert werden kann. Beispielsweise Stimme, Aussehen, Körperbewegungen/Gangart, Schreibstil, etc. Jede Art von Video enthält, sofern Personen darauf zu sehen oder zu hören sind, personenbezogene Daten. Je mehr Daten von einer Person zu sehen sind, desto leichter ist sie identifizierbar. Ist dagegen nur Text (z.B. Vortragsfolien) zu sehen, ist das Video wahrscheinlich frei von personenbezogenen Daten. Das Datenschutzrecht ist auf das Video nicht anwendbar. Die Prüfung endet hier. Ja, mein Video enthält personenbezogene Daten. Nein. Verantwortliche:r – Verantwortliche:r Beide Beteiligten bestimmen teilweise oder vollständig gemeinsam über die Zwecke und Mittel der Datenverarbeitung. Verantwortliche:r – Auftragsverarbeiter:in Die verantwortliche Stelle entscheidet allein darüber, was und wie die auftragsverarbeitende Stelle verarbeitet. Wird eine Video-Plattform gewählt, bei der eine Person/ Institution keine alleinige Kontrolle über Mittel und Zwecke der Datenverarbeitung hat, ist von dieser Konstellation auszugehen. Sie ist der/dem Redner:in klar und transparent mitzuteilen. Hier liegt in der Regel ein Vertrag zwischen den Beteiligten vor, der die Aufgabe (z.B. Produktion eines Videos) klar benennt und begrenzt. Die Auftragsverarbeitung erfüllt also nur fremde, keine eigenen Zwecke. Ja. Ja. Ja. Ja. Nein. Einwilligung, Art. 6 Abs. 1 lit. a DSGVO wissentliche und willentliche Zustimmung in die Datenverarbeitung Vertrag, Art. 6 Abs. 1 lit. b DSGVO beidseitig ausgehandelte Vereinbarung mit Leistung und Gegenleistung Berechtigtes Interesse, Art. 6 Abs. 1 lit. f DSGVO einseitige Feststellung eines überwiegenden Interesses an der Datenverarbeitung, die unbedingt notwendig ist oder oder Die Redner:in willigt ein, dass das Video auf einem Video- Portal hochgeladen wird und somit der Öffentlichkeit zur Verfügung steht. Der Vortrag ist Teil der Tätigkeit der Redner:in, beispielsweise als Professor:in oder Dozent:in. Es ist im eigenen Interesse des Instituts, das Video zu veröffentlichen. Beispielsweise handelt es sich um Videos zur eigenen wissenschaftlichen Tätigkeit der Mitarbeiter:innen. Der Upload bzw. die Verwendung des Videos für den geplanten Zweck verstößt gegen das Datenschutzrecht. Ich habe keine rechtliche Grundlage für die Verarbeitung, die ich nennen kann. Erhebung bei betroffener Person Art. 13 DSGVO ✓ Name und Kontaktdaten der verantwortlichen Stelle, ggf. Vertretung ✓ ggf. Kontaktdaten des/der Datenschutzbeauftragten ✓ Zweck(e) und Rechtsgrundlage(n) der Datenverarbeitung ➞ Art. 6, 9 DSGVO ✓ bei "berechtigtem Interesse": genaue Angabe dieser Interessen der verantwortlichen Stelle oder Dritter ✓ wenn vorhanden: Empfänger/Kategorien von Empfängern der personenbezogenen Daten ✓ wenn vorhanden: Absicht, Daten in ein Drittland (z.B. USA) zu übermitteln; eingeschlossen der Hinweis auf ein Vorliegen/ Fehlen eines Angemessenheitsbeschlusses ✓ sofern geplant: Speicherdauer ✓ Hinweise auf Betroffenenrechte: Recht aus Auskunft; Recht auf Berichtigung/Löschung; Einschränkung der Verarbeitung; Widerspruchsrecht; Recht auf Datenübertragbarkeit (sog. Interoperabilität) ✓ bei Einwilligung als Rechtsgrundlage: Hinweis auf Widerrufbarkeit der Einwilligung (Ob und Wie) ✓ Hinweis auf Beschwerderecht bei (zuständiger) Aufsichtsbehörde ✓ bei gesetzlicher Verpflichtung zur Verarbeitung: Angabe der gesetzlichen Grundlage; auch Information über Konsequenzen e
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Testing the formation mechanism of sub-stellar objects in Lupus (a SOLA team study) Brown dwarfs (BDs) are substellar objects with masses too low (M≤0.08MSUN) to burn hydrogen in their cores, some of them comparable with the mass of giant planets (M<0.013MSUN). Over the past two decades, a large number of brown dwarfs have been identified in star forming regions, open clusters, and in the field. However, it is still unclear how these objects form. The most widely discussed scenarios for the formation of BDs include turbulent fragmentation (Padoan & Nordlund 2004), disk fragmentation and subsequent ejection (Stamatellos & Whitworth 2009), photo-evaporation of massive pre-stellar cores (Whitworth & Zinnecker 2004), and ejection from multiple protostellar systems (Bate et al. 2002). Since stars and brown dwarfs evolve very rapidly during the first million years, the answer to the formation mechanism (or mechanisms) must be in the study of their properties when they are deeply embedded in the natal cloud, what we call the pre- and proto-BD stage. I. de Gregorio-Monsalvo1,2, C. López1,3; S. Takahashi1,4; A. Santamaría-Miranda2, 10, P. Cortés,1,3; F. Comerón2; A. Hales1,3; L. Knee5; D. Mardones6; K. Muzic7; A. Plunkett2; M. Saito4; K. Tachihara8; T. van Kempen9 , and the rest of the SOLA* collaboration. (1) Joint ALMA Observatory (Chile), (2) ESO (Chile), (3) NRAO (USA), (4) NAOJ (Japan), (5) CNRS (Canada), (6) U. Chile (Chile) , (7) CENTRA, U. of Lisbon (Portugal), (8) Nagoya U. (Japan), (9) SRON Netherlands Institute for Space Research, (10) U. Valparaíso (Chile), (*) Soul of Lupus with ALMA collaboration Submillimeter emission of substellar objects in Lupus I and III Lupus I and III southern molecular clouds are excellent laboratories to study the formation processes of sub-stellar objects. Our group (SOLA team) has identified a set of pre- and proto-stellar candidates of substellar nature using the literature as well as 1.1mm ASTE/AzTEC maps and analyzing its SED using our optical to submillimeter database. We performed ALMA continuum observations at 1.3mm and CO(2-1) using 0.8" spatial resolution towards the most promising pre- and proto-brown dwarfs candidates found in Lupus I and III molecular complexes. Our sample comprises 33 pre-stellar objects, 7 Class 0 and I objects, and 22 Class II objects. Lupus I Lupus III A B C D E F G H A B C D E F a b a b Fig 1 and 2: Central big maps represents Herschel SPIRE emission at 250 microns of Lupus I (left) and Lupus III (right). Smaller maps surrounding SPIRE maps are new ALMA continuum detections (> 6 sigma) at 1.3 mm. I Preliminary Results • Preliminary analysis of our data reveals ALMA continuum emission at 1.3mm in 17 source (see small panels in Figures 1 and 2), with object Lupus I-D being a submillimeter galaxy gravitationally lensed (Tamura et al. 2015) . Assuming the rest of the sources are associated to Lupus, we obtained a detection rate of ~30%. • Assuming emission at 1.3 mm is coming from dust, and adopting a Tdust = 10-15 K, a distance to Lupus d = 150-200 pc, a κν = 0.009 cm2 g-1 , and a gas to dust ratio of 100, we infer a Mass <0.013 Msun for all objects except for Lupus III-G (a known young stellar object surrounded by a protoplanetary disk), which falls into the range of planetary masses. • Using our multiwavelength SOLA catalog we checked for counterparts at other wavelengths and we analyzed the SEDs. LupusI- B, C, Ab, Fa, Fb, and E, and Lupus III – A, B, E, and F are deeply embedded protostars or starless pre-BD candidates, with no known counterpart at shorter wavelengths. Most of them are not resolved spatially and they would need to have a radius between 3 to 42 AU to be gravitationally unstable. Their real nature need to be further investigated. No extragalactic counterparts are found in the NED catalogue at the position of these objects. Lupus I – Aa is a sub-luminous (Lbol = 0.0026 Lsun) Class 0-I source, and Lupus III-C is a sub-luminous (Lbo l= 0.023 Lsun ) C
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Affective Modeling of Users in Cognitive Elements Exercise Program for Design Creativity Enhancement Yong Se Kim, Mee Kim, Yun Kyoung Shin, Hyejung Henny Park, In-Sook Lee Post-test Improvement over Pre-test Association Rules: Less Negative Emotion Learning Improvement Creative Design Institute, Sungkyunkwan University, Korea Creative Design Learning Framework Affective Modeling Experiment Result Design Creativity Cognitive Element Exercise Program Filling Black Box Classification Negation Sensitization Making Stories Decision Tree Experiment Process: Pre-test Post-test Cognitive Elements of Creativity Flexibility http://pssd.or.kr Product- Service Systems Design http://cdi.skku.edu Self-Reporting Format Originality Elaboration Problem Sensitivity Cognitive Elements Fluency Pre-test: Reading Devise Concept Design Exercise Program Post-test: Camera Device Concept Design Pre-test and Post-test: Conceptual Design Task Contact: yskim@skku.edu
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