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MATERIALS AND METHODS Biomethane gasometer Raw biogas gasometer 100L Tank Settler Biogas (G) Settled Biomass Liquid Recirculation (L) Domestic wastewater or centrate Raw biogas composition: Biogas upgrading using algal-bacterial processes in wastewater treatment plants M. Rosario Rodero1,3, Raquel Lebrero1,3, Esteban Serrano2, Enrique Lara2, Zouhayr Arbib2, Raúl Muñoz*1,3 1- Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n., Valladolid 47011, Spain. 2- FCC Servicios Ciudadanos, Av. del Camino de Santiago, 40, edificio 3, 4ª planta,28050 Madrid, Spain 3- Institute of Sustainable Processes, University of Valladolid, 47011, Valladolid, Spain * Author for correspondence: mutora@iq.uva.es INTRODUCTION RESULTS AND DISCUSSION CONCLUSIONS Negligible influence of the hydraulic retention time (HRT) in the HRAP and the biogas flowrate in the absorption column on the biogas upgrading performance. Higher CO2 and H2S removal efficiencies were obtained using centrate instead of domestic wastewater due to the higher alkalinity and pH of the influent. Higher L/G ratios entailed higher CO2 and H2S removals, but an increased stripping of N2 and O2 was observed, which negatively impacted CH4 concentration in the upgraded biogas. To the best of our knowledge, this work demonstrated for the first time the capacity of algal-bacterial systems for the simultaneous biogas upgrading and wastewater treatment at semi-industrial scale. References: [1] Toledo-Cervantes A., Serejo M., Blanco S., Pérez R., Lebrero R., Muñoz R., (2016). Photosynthetic biogas upgrading to bio-methane: Boosting nutrient recovery via biomass productivity control. Algal Res.17, 46-52. [2] Marín D., Posadas E., Cano P., Pérez V., Blanco S., Lebrero R. and Muñoz R. (2018). Seasonal variation of biogas upgrading coupled with digestate treatment in an outdoors pilot scale algal-bacterial photobioreactor. Bioresour. Technol. 263, 58-66 [3] Posadas, E., Serejo, M.L., Blanco, S., Pérez, R., García-Encina, P.A., Muñoz, R. (2015). Minimization of biomethane oxygen concentration during biogas upgrading in algal-bacterial photobioreactors. Algal Res. 12, 221–229. Acknowledgments:The project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 689242. Biogas, which mainly consists of CH4 (40-75%), CO2 (15-60%) and H2S (0.005-2%), constitutes a valuable renewable energy source able to reduce our current dependence on fossil fuels. In this context, H2S removal is mandatory due to its corrosive, malodorous and pernicious nature, while CO2 removal increases the specific calorific value and reduces biogas costs of compression and transportation [1]. Figure 2. Influence of the L/G ratio on biogas upgrading performance at biogas flowrate of 276 (black), 370 (white) and 459 (grey) L h-1 during stage I (a), stage II (b) and stage III (c). Effluent composition DWW, HRT= 3.5 days DWW, HRT = 8 days Centrate, HRT = 73 days COD (mg L-1) 99.4±31.3 65.0±21.7 123.8±0 N-NH4 + (mg-N L-1) 3.1±1.7 1.0±1.1 0±0 N-NO2 (mg-N L-1) 0.8±0.5 0.4±0.2 13.3±11.7 N-NO3 (mg-N L-1) 2.0±1.2 9.6±0.5 38.1±7.4 P-PO4 3- (mg L-1) 1.0±0.5 1.3±0.3 19.9±5.4 Figure 3. Wastewater removal efficiencies in the high rate algal pond during stage I (white), II (black) and III (grey) Table 2. Effluent composition under steady state conditions Objetive: To assess the influence on biomethane composition of: L/G ratio: 1.2, 2.1 and 3.5 Biogas flow rate (G): 274, 370 and 459 L h-1 Parameter Stage I II III Type of wastewater DWW DWW Centrate HRT (d) 3.5 8 73 Average temperature (°C) 23.5±2.5 12.4±2.3 18.8±3.0 Average pH in the cultivation broth 7.3±0.2 7.1±0.5 8.9±0.3 Figure 1. Schematic diagram (left) and photograph (right) of the continuous biogas upgrading experimental plant at Aqualia’s facility in Chiclana CH4 (%) 69.2±4.9 CO2 (%) 32.7±2.8 H2S (ppm) 1183±1006 Biogas upgrading in algal–bacterial photobioreactors re | poster |
9668 экземпляров жужелиц 2576 экземпляров мертвоедов 1446 находок отдельных видов 89 точек сбора материала Со времени подписания международной конвенции о биологическом разнообразии и разработки национальной стратегии по сохранению биоразнообра- зия в России прошло почти 30 лет. Многое было сделано в практическом плане этой области за последние годы (образование ООПТ). Однако, как можно пытаться сохранить то, что еще не полностью изучено? В Респуб- лике Татарстан да и в других соседних регионах вопросами биоразнообразия занимаются считанные диницы. Отсутствуют видовые списки для многих таксо- Недавно в GBIF были опубликованы 4 датасета от ИПЭН АН РТ, включающих более 1400 индивидуальных встреч видов жесткокрылых (рис. 1). В результате, на тер- ритории Европейской России появились виды жужелиц, ко- торые ранее там были единично отмечены в соответствии с сайтом (рис. 2). При этом на территории Европы эти виды порой представлены тысячами находок. Многие эти виды на самом деле имеют довольно широкое распро- странение на территории России, однако данные об этом приходится собирать из многочисленных литературных источников. Опыт внесения архивных данных по биоразнообразию беспозвоночных в GBIF Большую помощь в этом могут оказать электронные базы данных. Одним из таких ресурсов является GBIF, который бывает чрезвычайно полезен в некоторых случаях при обработке данных. За последние годы интерес к этому ресурсу в России значительно возрос, организуют семинары и конферен- ции. В прошлом году к GBIF присоединились десятки ООПТ и других организаций России. В Республике Татарстан это Волжско-Камский Заповедник. Для составления первой базы данных в GBIF, нами были взяты данные по распределению двух семейств Жесткокрылых (Жужелицы и Мертвоеды) в Волжско- Камском заповеднике, где исследования охватывают пе- риод с 2014 по 2019 гг. и в новом заказнике «Волжские просторы». Сборы из почвенных ловушек охватили около 12000 экз. Жуков определяли в лабораторных условиях, проверку определения некоторых видов проводили в Москве. В заповеднике исследованиями были охвачены 26 биотопов, на островах – 53. Таблицы приведены в соответствие с требованиями базы данных. Помимо внесения недавно полученных данных, в GBIF есть возможность публикации данных из литературных источников, а также архивных записей и коллекций. Лаборатория биомониторинга ИПЭН располагает обширной коллекцией сборов, начиная с 1910-х годов. Проводится активная работа по определению и систематизации материала, собранного не только в Республике Татарстан, но и в соседних регионах, многими энтомологами (Алейникова, 1964, 1979, Утробина, 1956, Жеребцов, 2000). Д.Н. Вавилов Институт проблем экологии и недропользования АН РТ, Казань sabantsev.ipen@gmail.com Результаты Рис. 1. Встречи жуков жужелиц и мертвоедов в исследуемом регионе до и после внесения данных в GBIF Рис. 2. Находки вида Paradromius linearis (G. A. Olivier, 1795) на терри- тории Европы и России | poster |
DOIs Should Not Link to Data In August of 2011, the National Academy of Science’s Board of Research Data and Information (BRDI) had a meeting on the topic of “Developing Data Attribution and Citation Practices and Standards”. As part of that meeting were various breakout groups to discuss issues that still remained regarding technical, scientific, and socio-cultural issues, the roles and actors that needed to be involved, and how to get additional feedback from the community. The technical breakout group decided that the majority of the technical problems with citing data revolved around establishing the identity of what it was that we were attempting to cite. As such, our recommendations were to push some of the work back onto the data publishers to tell us how scientists should cite their data (to avoid different disciplines applying different rules), establish ‘data landing pages’ to describe, document and link to the data, and to provide those pages with persistent identifiers such as a DOI. We present here some of the reasons that were discussed about why not to link directly to data, including: recalibration, reaccessioning and other data impermanence, setting context and providing links to documentation, and allowing selection of different packaging formats http://virtualsolar.org/ IN13B-1564 J.A. Hourclé NASA-GSFC (Wyle) joseph.a.hourcle@nasa.gov Data Impermanence: Recalibration / Versioning New processed forms of data create a slightly different problem from outright removal; as one form of the data is deprecated, a new form supersedes it Some projects will generate new calibrations of the data as the sensor degredation is better understood without a fixed release. Some data is released in near-real-time, with a reprocessing pass done after additional calibration tests are run. In the case of NASA’s Solar Dynamics Observatory’s (SDO) Atmospheric Imaging Assembly (AIA), data is available immediately after downlink, reprocessed 4 days later, then again 6 months later, each time improving the precision of the resultant data. Multiple calibrations of the same observation from SOHO/EIT For long-lived projects, the data is not fixed until after the data gathering concludes. The joint NASA/ESA Solar and Heliophysics Observatory (SOHO) was launched on December 2, 1995, with instruments that have been collecting data for almost 18 years and have not generated a ‘final data product’. Once these better calibrations are available, the older data is obsolete and, in some fields, discarded. Due to a lack of data citation standards, there is no easy way to identify which versions may have been used as part of the scientific record and should be maintaned long-term. Keeping all editions of the data is not cost-effective, and so only the raw data and ‘final data product’ are archived for the long-term. If people attempt to link to data that has been superseded, the archive has a few choices: Return the original data (or the replacement) We don’t know why someone was following the link: are they doing new research or trying to validate older work? Replacements may be suitable if your identifiers are for the observations (as is done in some Active Archives), but typically DOIs are used for objects with a fixed form and this would not be expected. Redirect to the replacement. This will give a clue that a replacement has been made, but most browsers and automated user agents will redirect without any indication that they did so. Return a message explaining what’s happened. Automated agents may not realize what’s happening. If served as a success (HTTP 200), they may assume it’s the data requested. If served as common redirections (HTTP 301 to 307), most user agents will redirect without displaying the message. HTTP 300 (Multiple Choices) without a Location header is your best option. You need a response is over 1024 bytes to avoid browser rewriting. Data Impermanence: Deaccessioning / Removal If data isn’t actively used by the designated | poster |
The highly contagious SARS-CoV-2 virus has generated an unprecedented pandemic with global dramatic public health and socio-economic consequences. Despite the progression of the global use of efficient vaccines, an increased transmissibility of variants of concern (VOC) is predominantly observed. Besides effective vaccination campaigns and new approved antivirals, hundreds of thousand patients have still been admitted to ICU in Europe in the first half of 2022. Passive immunotherapies based on monoclonal antibodies have shown a drop of neutralization potency against VoCs. A polyclonal approach might be effective to neutralize fast-evolving VoCs and prevent worsening medical conditions for hospitalized patients at risks. The main objective of the European EPIC-CROWN-2 consortium is to rapidly assess, in multicentric clinical trials (phase IIa/b) an EMA-authorized antiviral immunotherapy based on potent and broad equine neutralizing anti-SARS-CoV-2 polyclonal F(ab’)2 antibodies in COVID-19 patients, including VOC carriers. Production of equine neutralizing anti-SARS- CoV-2 polyclonal F(ab’)2 antibodies Phase 2a cohort 1: Patient’s enrolment completion Validation of the Safety profile of FBR-002 by the DSMB Phase 2a cohort 2: Ongoing patients' enrolment Belledant A.¹, Luczkowiak J.³, Delgado R.³, Rodriguez E.⁴ , Veas F.⁵, Giamarellos-Bourboulis E.², Herbreteau C.H.¹* ¹FAB’ENTECH (Lyon, France), ²HISS Hellenic Institute for the Study of Sepsis, Athens, Greece, ³IMAS12, Instituto de Investigación Hospital Universitario 12 de Octubre (Madrid, Spain), ⁴BNITM, Bernhard Nocht Institute for Tropical Medicine (Hamburg, Germany), ⁵IRD, Institute of Research and Development (Montpellier, France) *Corresponding Author: scientific.communication@fabentech.com Luczkowiak J, Radreau P, Nguyen L, Labiod N, Lasala F, Veas F, Herbreteau C.H, Delgado R. Potent Neutralizing Activity of Polyclonal Equine Antibodiesagainst SARS-CoV-2 Variants of Concern. J Infect Dis. 2022. DOI: 10.1093/infdis/jiac331 Table . Neutralizing Levels for FBR-002 Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Authentic Clinical Isolates, SARS-CoV-2 Pseudotyped Particles, and Controls and Median Inhibitory Concentrations With Sotrovimaba FBR-002 exhibits significant neutralizing activity against current described VoCs including Omicron subvariants BA.4/5 FBR-002 neutralizing potency x100 as compared in humans after COVID-19 mRNA vaccines FBR-002 neutralizing activity more resilient against VoC than clinically approved mAbs Highly purified polyclonal F(ab')2 fragments Based on a technology developed by Sanofi Pasteur and licensed to Fabentech Standard production process FAB’ENTECH PLATFORM EPIC CROWN-2 CLINICAL TRIAL PROJECT EQUINE POLYCLONAL ANTIBODIES IMMUNOTHERAPY AGAINST COVID-19/SARS-COV2–VOC IN VITRO STUDIES : SARS-COV-2 NEUTRALIZING ASSAYS OF FBR-002 EVOLUTION OF SARS-COV-2 VOC NEUTRALIZING LEVELS METHODOLOGY NEUTRALIZATION OF SARS-COV-2 VOC (FBR-002) KEY STATEMENTS CLINICAL BATCH OF FBR-002 PRODUCTION VALIDATED HIGH NEUTRALIZING POTENCY OF FBR-002 TO SARS COV-2 VOCS IN VIVO EFFICACY OF FBR-002 ONGOING SAFETY PROFILE OF FBR-002 UNDER EVALUATION IN PHASE 2A CLINICAL TRIAL | poster |
Safe-, sUstainable- and Recyclable-by design Polymeric systems A guidance towardS next generation of plasticS Simon Clavaguera1 on behalf of the SURPASS consortium 1 Université Grenoble Alpes, CEA LITEN, DTNM, 17 rue des Martyrs 38000 Grenoble, France Background, Motivation and Objectives Concept, Methodology and Implementation simon.clavaguera@cea.fr Project funded by the European Union under the Horizon Europe work programme grant agreement N° 101057901. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. Acknowledgements and funding information 1. Develop SSRbD alternatives with no potentially hazardous additives through industrially relevant case-studies (TRL3-5) targeting the three sectors representing 70% of the European plastic demand: - Building: bio-sourced polyurethane resins with enhanced vitrimer properties to replace PVC for window frames (≥ 40% carbon footprint reduction) - Transport: lightweight, therefore less energy-consuming epoxy-vitrimer (≥30% carbon footprint reduction), as alternative to metal for the train structure, anticipating emerging use of non-recyclable composites. - Packaging: MultiNanoLayered films involving no compatibilizers to replace currently non-recyclable multi-layers films (≥60% carbon footprint reduction). Plastic waste outlive us on this planet as they take centuries to break down. The hazard of endocrine disruption by leached substances, fast growing and pollution of land, air and water as well as greenhouse gas emissions are only some of the adverse effects of plastic waste on public and environmental health. Still, 70% of plastic waste collected in Europe is landfilled or incinerated. The overall objective of SURPASS project is to lead by example the transition towards more Safe, Sustainable and Recyclable by Design (SSRbD) polymeric materials. The SURPASS consortium will: 2. Optimize reprocessing technologies adapted to the new SSRbD systems to support achievement of ambitious recyclability targets. 3. Develop a scoring-based assessment that will guide material designers, formulators and recyclers to design SSRbD polymeric materials, operating over the plastic’s entire life cycle, including hazard, health, environmental and economic assessment. 4. Merge all data and relevant methodologies in a digital infrastructure, offering an open-access user-friendly interface for innovators. Consortium 1. CEA: Commissariat à l’Energie Atomique et aux Energies Alternatives, France 2. IPC: Centre Technique Industriel de la Plasturgie et des Composites, France 3. CIDETEC: Fundacion CIDETEC, Spain 4. LEITAT: Acondicionamiento Tarrasense Associacion, Spain 5. INDRESMAT: Indresmat SL, Spain 6. UGA: Universite Grenoble Alpes, France 7. GEONARDO LTD: Geonardo Environmental Technologies Ltd, Hungary 8. BASF SE: BASF SE, Germany 9. RIVM: Rijksinstituut voor Volksgezondheid en Milieu, Netherlands 10. UNE: Asociacion Espanola de Normalizacion, Spain 11. FhG ICT: Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung EV, Germany 12. WIPAK: WIPAK Gryspeert SAS, France 13. WFO: Waste Free Oceans Europe, Belgium The SURPASS consortium of 13 partners consisting of research and technology organizations and industries will in particular address its results to SMEs, representing more than 99% of enterprises, and therefore has an outstanding potential to contribute to the transition towards green economy | poster |
Orphan medicines legislation General pharmaceutical legislation 7 May - 30 July 2021 28 Sept. - 21 Dec. 2021 303 answers including 12 public authorities from 9 Member States* 478 answers including 31 public authorities from 15 Member States** IMPROVING ACCESS TO INNOVATIVE MEDICINES: IMPROVING ACCESS TO INNOVATIVE MEDICINES: PROPOSALS FROM NATIONAL AUTHORITIES PROPOSALS FROM NATIONAL AUTHORITIES TO REVISE THE EUROPEAN LEGISLATION TO REVISE THE EUROPEAN LEGISLATION A u r é l i e M a h a l a t c h i m y [ 1 ] , F l o r e n c e L a n s o n [ 2 ] , B l a n k a B a r t o s [ 3 ] , F l o r e n c e T a b o u l e t [ 4 ] MAIN PROPOSALS FROM NATIONAL AUTHORITIES Proportionate to the level of UMN (e.g. variable duration of market exclusivity) Focused on neglected therapeutic areas Conditional to certain obligations Be transparent on R&D costs and actual prices Launch in all or most Member States UMN re-evaluated after commercialization Use experiences developped from covid-19 crisis Joint procurement Flexibility in clinical trials conduct On the incentives granted to sponsors On the criteria for orphan designation To be adjusted to avoid "salami slicing" (segmenting therapeutic indications) To be taken into account with the severity of the disease (level of unmet medical need - UMN) Prevalence : < 5 in 10,000 persons in the EU To be clarified and graduated Significant benefit : no EU satisfactory method of diagnosis, prevention or treatment, or drug significant benefit Many isolated proposals : difficult to identify a consensus among the authorities Request of better cooperation between all agencies and more EMA support BUT emphasis on respecting the EU and Member States competences sharing > Orphan single status transformed into a mosaic of statuses Complexities : how to quantify ? which indicators ? > Future EU considerations of national authorities proposals and answers from other respondents ? Patient access to medicines Health systems sustainability Innovation support EU legislation Objectives to be balanced 80% of rare diseases are of genetic origin in the EU = Many advanced therapies have obtained the orphan medicine status under European regulation (EC) n° 141/2000 of 16 December 1999 on orphan medicial products Provides orphan designation and incentives (market exclusivity for 10 years) Ensure the relevance of incentives granted to industry (to avoid abuses) Reward risk-taking and innovation more Improve equitable patient access in the EU Needs to be revised. Why? Public consultations on revision of European legislation DISCUSSION AND CONCLUSION [1] Permanent Researcher in law at the French National Centre for Scientific Research (CNRS, research fellow), Law Faculty, UMR 7318 International, Comparative and European law (DICE) CERIC, CNRS, Aix Marseille University, Toulon University, Pau & Pays de l’Adour University, Aix-en-Provence, 13628, France. ; [2] CERPOP (Center for Epidemiology and Research in POPulation health), UMR 1295 Inserm, University of Paul Sabatier- Toulouse 3, Toulouse, 31062, France. ; [3] PhD Student in law, CREDIMI, University of Burgundy, Dijon, 27877, France. ; [4] Professor in Pharmaceutical Law and Health Economics, CERPOP, UMR 1295 Inserm, University of Paul Sabatier- Toulouse 3, Toulouse, 31062, France. Acknowledgement: This work has been supported by ANR-funded I-BioLex project (ANR-20-CE26-0007-01, coord. A. Mahalatchimy). *AT, DE, DK, ES, FI, FR, HU, NL, SE ; **AT, BE, CZ, DE, DK, EE, ES, FI, FR, HU, IS, MT, NL, PT, SE | poster |
Rapid Characterisation of hERG Kinetics Using Optimised Protocols on a High-Throughput System Chon Lok Lei1, Michael Clerx1, David J. Gavaghan1, Liudimila Polonchuk2, Gary R. Mirams3, Ken Wang2 1. Computational Biology, University of Oxford, UK; 2. Pharma Research & Early Development, Roche, Switzerland; 3. Centre for Mathematical Medicine & Biology, University of Nottingham, UK chon.lei@cs.ox.ac.uk [1] Beattie et al. (2018) J. Physiol. [2] Traynelis (1998) J. Neurosci. Methods [3] Sherman et al. (1999) Biophys. J. 0 2 4 6 8 10 12 14 100 0 Voltage [mV] A Calibration B 0 2 4 6 8 10 12 14 20 0 20 Current [A/F] data model fit to data Time [s] Validation 1 Validation 2 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 50 0 Voltage [mV] Validation 3 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 50 0 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 50 0 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0 5 10 Current [A/F] 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 Time [s] 0 10 20 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0 5 10 Voltage [mV] 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 50 0 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 Time [s] 50 0 Voltage [mV] Time [s] Current [A/F] 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 0 10 data model prediction 40 20 0 20 40 0.0 0.5 1.0 Normalised Current Voltage [mV] Validation 4 Validation 5 0 1 2 3 4 p1 0 2 4 1e2 40 60 80 p2 0 1 2 0.0 0.1 0.2 0.3 0.4 0.5 p3 0 1 2 1e3 30 40 50 60 70 p4 0.00 0.25 0.50 0.75 1e1 200 300 400 500 600 p5 0.0 0.5 1.0 1.5 Normalised frequency 1e 1 10 20 30 40 50 p6 0 1 2 3 20 40 60 p7 0.0 0.5 1.0 1.5 20 25 30 35 40 p8 0 1 2 3 0 2000 4000 6000 gKr 0 1 2 1e 1 1 2 3 4 5 6 noise 0.0 0.5 1.0 1.5 1e2 0 2 4 1e 4 0 2 4 6 1e 1 0 1 2 3 1e 2 0.0 0.5 1.0 1e1 0 2 4 1e 2 0 2 4 1e 3 0 2 4 Probability density 1e 2 0 1 2 3 1e 2 0.0 0.5 1.0 1e 1 3.5 Model Parameters Correlation 3.3 Variability Across Experiments 3.2 Model Validation 3.1 Experimental Design / Model Training/Fitting Hierarchical Model Structure 1. Introduction Variability in hERG Kinetics References Fig 2: An optimised protocol that is designed for high throughput machine to recover model parameters. It shows the actual experimental measurement and the fitted model. Fig 3: Independent experimental measurements of the same cell to use as model validation. Here we used both 'traditional' protocols (Validation 4, 5) and new physiologically inspired [1] protocols (Validation 1-3) which are the AP-like, EAD-like and DAD-like waveforms. We repeated the same experiment on the same cell-line and recorded 65 individual cell measurements. Can we capture experiment-to- experiment variability? Fig 5: A hierarchical Bayesian model (HBM) was used to capture experiment- to-experiment variability. Marginal distributions of each experiment are shown, which reveal the variability between experiments. The posterior predictive distributions from the HBM are shown in red. Hodgkin-Huxley formulation 2. Cardiac hERG Channel Model 3.4 Consideration of Experimental Error Model The above analyses have assumed experiments were done 'perfectly'. That is we have assumed our input of the command voltage V was what the cell experienced as the membrane voltage Vm during the experiment. However, this might not be exact [2, 3]. Therefore we have also considered the possible error source in the experiment, as error model, to give: where 'mechanistic model' is our IKr model and 'noise model' is a simple Gaussian/white noise model. Fig 6: The 95% C.I. contour plots of the inferred covariance matrix, together with each parameter values. It shows a compar- ison of the parameter varia- bility (blue) and the effect of the voltage error model (red) on synthe- tic data. Fig 5: A schematic of the full hierarchical Bayesian model, which is a multi-level modelling technique that combines individ- ual measures (lower level) as a group (top level). Prior distributions are specified for the , , . This allows us to combine multiple experiments into one causal structure. Notation: 4. Experimental Methods This is not the end! Acknowledgements Fig 1: A simp | poster |
Towards a datafication of Antwerp street life? Co-creating a dataset of 100.000 pages of handwritten police reports (1876-1945) INCIDENT BOOKS OF ANTWERP = Reports of daily and nightly police patrols on district level dealing with prosecuted and non- prosecuted crime ▻Serial character = consistent registration over time of • personal data of people involved: name, profession, date and place of birth, place of residence • incident: location, date, time of day, detailed description • follow-up of the incident Coming soon: open access publication of dataset and HTR-model Contact: Lith Lefranc (Lith.Lefranc@UAntwerpen.be) PhD advisors: Ilja Van Damme and Mike Kestemont RESEARCH POTENTIAL ▻Rare window on bottom-up practices and lived experiences of ordinary people ▻Data-driven approach to history of local policing, working-class history, history of mentalities, gender and sexuality history, history of the everyday, youth and family history… ▻Dataset specifics • 289 incident books • 97,498 images • ± 30,500,000 words of (automatic) transcriptions in various file formats • Languages: French and Dutch • 11 districts of Antwerp • Time span: 1876-1945 Training Material #Words CER Ground truth 78,581 12.3% Ground truth + best 1/3 students 370,206 9.0% Ground truth + best 2/3 students 734,857 8.0% Ground truth + all students 978,672 7.9% HANDWRITTEN TEXT RECOGNITION ▻Challenges: • Numerous different handwritings • Bilingual: French + Dutch • Complex layout (esp. skewed text) ▻HTR-model training: combination of gold with semi-gold standard training material (students) – created in Transkribus ▻Error analysis: • Exclusion of skewed text • Exclusion of punctuation, capital letters, whitespace in CERberus Relaxed CER: 4.7% 0 5000 10000 15000 20000 25000 30000 1876-1882 1883-1889 1890-1896 1897-1903 1904-1910 1911-1917 1918-1924 1925-1931 1931-1938 1939-1945 Number of pages Sample periods Distribution by sample period 1 May 1885 Mr Sergoynne draw up an official report D At 9 ½ hours in the evening I saw that the maid from the house N° 57 in the Leopoldst was beating rugs against the wall of the guesthouse when I came over she ran away inside the house and didn’t come outside any more (she caused a flood of dust) Broes, Dymphna, 16 years, born in Minderhout, maid, residing in Leopoldstr 57 Because she was so young and she didn’t know better, I didn’t follow up on this. | poster |
Correlations in molecular content of oxygen-rich AGB and RSG stars Sofia Wallström1, Leen Decin1, Carl Gottlieb2, Holger Müller3, Taïssa Danilovich1, Fabrice Herpin4, and the ATOMIUM collaboration5 1. Institute of Astronomy, KU Leuven, Belgium. 2. Harvard Smithsonian Center for Astrophysics, Cambridge, Massachusetts, USA. 3. I. Physikalisches Institut, Universität zu Köln, Germany. 4. Laboratoire d’astrophysique de Bordeaux, Université Bordeaux, France 5. https://fys.kuleuven.be/ster/research-projects/aerosol/atomium/atomium Background The ATOMIUM ALMA large project aims to establish the dominant physical and chemical processes in the winds of oxygen-rich evolved stars over a range of ini@al stellar masses, pulsa@on behaviours, mass-loss rates, and evolu@onary phases. Through high-resolu@on (~0.025" - 0.05") observa@ons in bands between 214 and 270 GHz, we have detected 286 molecular lines of 23 different molecules and their isotopologues, in vibra@onal states up to v=5. The eventual unravelling of the complex chemistry of these sources will provide astrochemical knowledge that will strongly impact research on supernovae, protostars, interstellar clouds, ac@ve galac@c nuclei, etc. — environments in which it is far more difficult to grasp the dust nuclea@on process. As a star@ng point for the chemical analysis, we have calculated Pearson's linear correla@on coefficients between the molecular content of each source and its (circum)stellar parameters: mass-loss rate, expansion velocity, and pulsa@on type. Ini.al results We see some expected correla@ons with mass-loss rate: a higher wind velocity and molecular tracers of dense winds such as H2S, as well as the rarer Al-bearing molecules. Lower wind velocity, conversely, is correlated with the detec@on of H2O and to a lesser extent OH. Mira pulsator sources are correlated with detec@ons of a somewhat random list of molecules: SiS, CS, PO, AlF, and KCl. The metal oxides PO, TiO, and AlO are well correlated, as expected, though TiO2 is not. AlOH is beaer correlated with the metal halides, which are also nicely correlated with each other, with the excep@on of KCl. KCl also shows no correla@on with mass-loss rate, unlike the other metal oxides and halides. However, these outlier molecules tend to have fewer and weaker detected lines, which may explain the observed trends. All results should be treated as preliminary! Note that we also detect more carbonaceous molecules, such as HC3N and SiCC, as well as the nitrogen-bearing SiN, but only in the singular S-type star W Aql and hence they are not included in the correla@on table. VX Sgr and W Aql are the most line rich sources in our sample, with ~5.5 and ~3.8 lines/GHz, respec@vely. Correla.ons between sources: Table of linear correla@on coefficients, colorized by value from green (1.0 = perfect correla@on) to pink (-1.0 = perfect an@-correla@on), calculated using values of mass-loss rate and expansion velocity, and designa@on as 0 or 1 in pulsa@on type (Mira or other) and molecular content (line detec@on at a 3σ level) Source Puls MLR vWind S Pav SRa 8.0E-08 9 T Mic SRb 8.0E-08 4.8 U Del SRb 1.5E-07 7.5 R Hya Mira 2.0E-07 12.5 RW Sco Mira 2.1E-07 11 SV Aqr LPV 3.0E-07 8 V PsA SRb 3.0E-07 14.4 U Her Mira 5.9E-07 15 pi Gru SRb 7.7E-07 30 AH Sco SRc 1.0E-06 23 W Aql Mira 3.0E-06 17.2 R Aql Mira 3.5E-06 8 KW Sgr SRc 5.0E-06 27 GY Aql Mira 6.0E-06 13.6 IRC-10529 Mira 1.0E-05 13 IRC+10011 Mira 1.0E-05 23 VX Sgr SRc 6.1E-05 24.3 Source table: The ATOMIUM sample of AGB and RSG stars, along with their pulsa@on type, mass-loss rate (in solar masses per year) and expansion velocity (in km/s), taken from the literature. | poster |
Shea Jiun Choo1, Sabariah Noor Harun2, Balamurugan Tangiisuran2, Chee Tao Chang3, Mohd Faiz Abdul Latif,4 Nor Aida Sanusi5 C-06 1.Taiping Hospital 2. School of Pharmaceutical Sciences, Universiti Sains Malaysia 3. Clinical Research Centre, Raja Permaisuri Bainun Hospital, 4. Taiping Health Clinic 5. Pharmaceutical Services Division, Perak State Health Department A MULTICENTRE RETROSPECTIVE COHORT STUDY ON TREATMENT OUTCOME OF VARENICLINE Characteristics (n=114) Frequency (%) Treatment duration (week), in mean ± SD 8.8 ± 3.3 Smoking abstinence rate Successful Unsuccessful 68 (59.6) 46 (40.4) Type of adverse events Frequency (%) Cardiovascular related Hospitalization Angina pectoris 2 (1.8) 1 (0.9) Neuropsychiatric related Altered behaviour Auditory hallucination 2 (1.8) 1 (0.9) Others Increased appetite Dizziness Dry mouth Nausea Abnormal dreams Insomnia Stomach discomfort Others 19 (16.7) 18 (15.8) 12 (10.5) 10 (8.8) 9 (7.9) 9 (7.9) 6 (5.3) 21 (18.5) Characteristics (n=114) Frequency (%) Age (years), in mean ±SD 46.0 ± 14.4 Gender Male Female 104 (91.2) 10 (8.8) Ethnic Malay Chinese Indian 70 (61.4) 17 (14.9) 27 (23.7) Number of cigarette smoked per day (sticks), in mean ± SD 17.0 ± 11.3 Duration of smoking (years), in mean ± SD 26.6 ± 14.9 Fagerstrom score 0 to 3 (Low dependence) 4 to 5 (Moderate dependence) 6 to 10 (High dependence) 42 (36.8) 28 (24.6) 44 (38.6) Attempts to quit Yes No 79 (69.3) 35 (30.7) Table 4: Logistic regression model predicting successful smoking abstinence Variables Adjusted odd ratio 95% CI P-value Number of cigarette/day 1.102 0.929, 1.103 0.785 Duration of smoking 0.800 0.639, 1.003 0.053 Fagerstrom score High Low-to-moderate Reference 1.033 0.164, 6.519 0.972 Without quit attempt 0.330 0.066, 1.657 0.178 Readiness to quit Pre-contemplation & contemplation Preparation & action Reference 5.145 1.005, 26.328 0.049 Treatment duration 2.445 1.735-3.445 <0.001 Adverse events 0.096 0.014, 0.644 0.016 Withdrawal symptoms 0.032 0.016, 0.835 0.032 NMRR-18-2984-44113 (IIR) ACKNOWLEDGEMENT We would like to thanks the Director General of Health, Ministry of Health Malaysia for his approval to present this study. REFERENCES 1. Cahill, K., et. al. 2013. Pharmacological interventions for smoking cessation: an overview and network meta‐analysis. Cochrane database of systematic reviews, (5). 2. Ware, J.H., Vetrovec., et al. 2013. Cardiovascular safety of varenicline: patient-level meta-analysis of randomized, blinded, placebo-controlled trials. American Journal of Therapeutics, 20(3), pp.235-246. 3. Anthenelli, R.M., et.al 2016. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. The Lancet, 387(10037),pp.2507-2520. Table 1: Demographic characteristics of patients Table 3: Adverse drug events experienced by patients Table 2: Treatment duration and rate of smoking abstinence | poster |
A new 2 km Sea Surface Temperature Atlas of the Australian Regional Seas (SSTAARS) Summary We use 25 years of Advanced Very High-Resolution Radiometer (AVHRR) data from NOAA Polar Orbiting Environmental Satellites received by six Australian and two Antarctic receiving stations to construct a detailed climatology of sea surface temperature (SST) at 20 cm depth around Australasia. • Raw scans have been accurately navigated • Only night-time nearly cloud-free data are used to reduce diurnal bias and cloud contamination • Irradiances have been processed and fitted to in situ drifter data following international GHRSST protocols to help reduce instrument bias • A pixel-wise (2km) climatology (with four annual sinusoids) and linear trend are fit to the data using a robust fitting technique • Monthly non-seasonal percentiles are also derived Validation • Used temperatures from coastal tide gauges and wave-rider buoys, not used to de-bias the satellite data (Figure 1a) • Climatology based on in situ observations was compared to SSTAARS • The major driver of difference is the distance between the in situ site and the nearest Atlas pixel (Figure 1b). • The more offshore wave-rider sites show very good agreement with the Atlas as they can be most closely collocated with an Atlas pixel • For co-locations within 3km, RMS errors are 0.2o C or less, and within 1km, 0.1o C or less, comparable to the average drifter matchup errors Susan E. Wijffels1,2, Helen Beggs3, Christopher Griffin3, John F. Middleton4, Madeleine Cahill1, Edward King1, Emlyn Jones1, Ming Feng1, Jessica A. Benthuysen5, Craig R. Steinberg5 and Phil Sutton6 Key phenomena revealed • Indonesian Throughflow warm advection (Figures 4 and 5) • Summer tidal drawdown over tropical shelves (Figures 6 and 7) • Tidally-driven reef-flat mixing (Figures 6 and 7) • Boundary current flows and their seasonality (Figures 8 and 9) • Cross-shelf gradients of variance due to mesoscale eddies (Figure 9) • Suppression of the annual cycle by warm advection along the Lleeuwin Current pathway (Figures 8 and 9) Data Access SSTAARS Atlas files: https://portal.aodn.org.au/search?uuid=79c8eea2-4e86-4553-8237-4728e27abe10 IMOS AVHRR daily night-time L3S data used as input: https://portal.aodn.org.au/search?uuid=79c8eea2- 4e86-4553-8237-4728e27abe10 Figure 1: a) Locations of long and relatively continuous near surface in situ temperature records from either coastal tide gauge sites (SL) or offshore wave-rider sites (WR); b) RMS difference in the seasonal cycle between the in situ and Atlas estimates as a function of distance between the in situ measurement site and the nearest Atlas pixel. 1 CSIRO Oceans and Atmosphere, GPO Box 1538 Hobart, TAS 7001 Australia 2Woods Hole Oceanographic Institution, MS #29, 266 Woods Hole Road, MA 02540, USA 3 Bureau of Meteorology, Docklands, VIC 3008, Australia 4 South Australian Research and Development Institute, West Beach, SA 5024, Australia 5 Australian Institute of Marine Science, Townsville, QLD 4810, Australia 6NIWA, Wellington, New Zealand Coverage • The coverage for June and December is shown in Figure 3 in observation count per pixel • Sampling is very seasonally dependent, due to cloudiness • Pixels near Australia have more observations, with sampling dropping off with distance from Australian satellite receiving stations due to reduced reception of direct broadcast NOAA satellite data by these receivers. Figure 2: Estimates of the linear SST trend from 3/1992-12/2016: a) from the IMOS SST archive and b) from the NOAA OI V2 weekly SST. Units are oC/decade and the contour interval is 0.2C/decade. Grey stippled regions mark where the trend is smaller than 2 times the standard error (95% significance level). 25 Year Trends Figure 4 (top left): Climatological SST from the Atlas for the Indonesian Seas shown every 2 months. The colour scale is adaptive and changes every month to help better reveal spatial contrasts. Grey contours mark the 50m (thin) and 200m (thic | poster |
Potential CO2 storage sites Stenlille • The reservoir occurs within a domal closure and is overlain by a 300 m thick clay sequence of the Fjerritslev formation. • A 140 m thick upper Triassic Gassum sandstone formation 1500– 1600 m below the surface. • As of 2017, there are 14 injection and production wells as well as 6 observation wells. • Smooth operation of the natural gas storage site since 1989. • The geological setting at Stenlille is assumed to represent a good analog to the Havnsø structure since similar lithologies and burial depths for the Gassum formation are expected. • The average porosity (25%) and permeability (250 mD) in the Gassum sandstone reservoir at Stenlille represent good conditions for geological CO2 storage. • The Stenlille dataset is the most comprehensive onshore dataset in Denmark (cuttings descriptions, core analysis data, wireline logs, well completions reports, well test reports, seismic data, geochemical data, and historical records of injection and production rates of natural gas, as well as bottomhole and wellhead pressures and temperatures). Havnsø • One of the most prospective CO2 storage sites in Denmark. • Proximity of large CO2 emission sources: a biomass-fired power plant and a refinery close to Kalundborg; supplementary CO2 point sources in Copenhagen. • No wells have been drilled and only low-quality seismic data is available (new seismic was acquired in August-October 2022). Reservoir models • CO2-water isothermal model without geochemical reactions • Phase properties are modelled as functions of pressure. Stenlille • The model, covering approximately 7,760 x 3,570 x 137 meters, contains 119,634 active cells with properties, adjusted to represent faults and fractures. • The reservoir consists of 6 zones, separated by impermeable layers. • The model is history matched to natural gas injection/production and pressure data, which makes it a good candidate to model CO2 injection. Havnsø • The reservoir model is based on the Top Gassum map, obtained from seismic interpretation. • A uniform thickness reservoir of approximately 20,000 x 15,000 x 150 m has 4,959,998 active cells. • The distribution of rock properties follows the suggested depositional pattern from Stenlille. In a net-zero CO2 emission economy, the CO2 transportation and storage networks will need to accommodate fluctuations in CO2 feed- flows. This calls for a need to assess different strategies for temporary storage of CO2. The objective of the present work is to evaluate the efficiency of temporary CO2 storage in saline aquifers for the case of two geological sites in Denmark, Stenlille and Havnsø. Specifically, we study the sensitivity of CO2 recovery factor with regards to the parameters of the CO2-water relative permeabilities and capillary pressures. The results of the sensitivity study demonstrate a critical role of rock-fluid interactions and accurate reservoir characterization on the estimates of CO2 recovery. In all considered injection/production scenarios, the efficiency of temporary CO2 storage does not exceed 30%; achieving this recovery factor is only possible if a large amount of CO2 is injected in the reservoir for permanent storage (several hundred thousand tons for the considered cases). The duration of this initial CO2 injection is of the order of years so that the caprock integrity will not be compromised. Sensitivity study on CO2 recovery during temporary storage • Sampling the parameters of the saturation functions within the ranges from the literature. • Quantifying the impact of uncertainty in relative permeability and capillary pressure on the CO2 recovery factor (RF) during temporary storage. • Modelling CO2 injection in a vertical well, located at the top of the Stenlille and Havnsø structures. • Injection for 10 years with a constant bottomhole pressure control, followed by 10 years production with the constant topside pressure control. Stenlille • A large spread in CO2 recovery factors, depending | poster |
Seit ihrer Gründung im Jahr 1661 ist die Staatsbibliothek zu Berlin für die Öffentlichkeit zugänglich. In dieser Tradition sowie im Bewusstsein ihrer besonderen historischen Verantwortung steht die Staatsbibliothek zu Berlin zu ih- rer Verpflichtung, wissenschaftliches Wissen der Gesellschaft unbeschränkt und gleichberechtigt zur Verfügung zu stellen. Als Einrichtung der Stiftung Preußischer Kulturbesitz hat sie die Berliner Erklärung über den offenen Zugang zu wissenschaftlichem Wissen unterzeichnet. Deren Ziel ist es, Open Access zu be- fördern – also sowohl den offenen Zugang als auch die freie Nachnutzung von wissenschaftlichen Wissensbeständen einschließlich der diesen zugrunde liegenden Daten. In ihrer Funktion eines Zentrums der überregionalen Literatur- und Informationsversorgung sowie als größte wissenschaftliche Universal- bibliothek in Deutschland hat die Staatsbibliothek zu Berlin Open Access als ein zukunftsweisendes Handlungsfeld in den Blick genommen und zum festen Be- standteil ihrer strategischen Weiterentwicklung gemacht. Nicht zuletzt auch im Kontext der im Oktober 2015 beschlossenen Open Access-Strategie für Berlin hat die Staatsbibliothek zu Berlin verschiedene Themenbereiche identifiziert, in denen sie Open Access unterstützen kann. Sie engagiert sich daher für die Digitalisierung und offene Zugänglich- machung ihrer urheberrechtsfreien Bestände, Bereitstellung geeigneter Infrastrukturen für das Publizieren im Open Access, Sicherung und Erschließung amtlicher Open Access-Veröffentlichungen, Freigabe der von ihr erstellten bibliographischen Metadaten an die Allgemeinheit, zielgruppenspezifische Beratung zu Fragen von Open Access und Open Science, Transformation des wissenschaftlichen Publikationssystems. DIGITALISIERUNG UND OFFENE ZUGÄNGLICHMACHUNG URHEBERRECHTSFREIER BESTANDSSEGMENTE FREISTELLUNG BIBLIO- GRAPHISCHER METADATEN verantwortet mit der Zeitschriftendatenbank in Koope- ration mit der Deutschen Nationalbibliothek den welt- weit größten Katalog für den Nachweis von Periodika übergibt alle kooperativ erstellten Titeldaten der Zeit- schriftendatenbank als maschinenlesbare Linked Open Data der Public Domain stellt ihre eigenen Katalogisierungsdaten unter der Cre- ative Commons-Lizenz CC0 der Allgemeinheit zur be- liebigen Nutzung zur Verfügung BEREITSTELLUNG VON INFRASTRUKTUREN FÜR DAS PUBLIZIEREN IM OPEN ACCESS SICHERUNG UND ERSCHLIESSUNG AMTLICHER OPEN ACCESS- VERÖFFENTLICHUNGEN ist Depotbibliothek für Dokumente internationaler Organisationen sowie offizielle Sammelstelle für Publikationen öffentlich- rechtlicher Einrichtungen der Bundesrepublik Deutschland setzt sich in dieser Funktion für die langfristige Zugänglichkeit amtlicher elektronischer Publikationen im Open Access ein MITGESTALTUNG DER TRANSFORMATION DES WISSENSCHAFTLICHEN PUBLIKATIONSSYSTEMS ist Teil des Finanzierungskonsortiums Knowledge Unlatched, das die Publikation sozial- und geisteswissenschaft- licher Monographien im genuinen Open Access ermöglicht bekennt sich zum Ziel der Transformation des subskriptionsbasierten wissenschaftlichen Publikationssystems spricht im Rahmen der Schwerpunktinitiative Digitale Information der Allianz der deutschen Wissenschaftsorgani- sationen Empfehlungen aus – u.a. zur Schaffung eines wissenschaftsadäquaten Open Access-Publikationsmarkts verhandelt im Auftrag von Bibliotheken und Universitäten aus ganz Deutschland überregionale Lizenzen für elektronische Informationsangebote – unter Berücksichtigung möglichst liberaler Zweitveröffentlichungsrechte ZIELGRUPPENSPEZIFISCHE BERATUNG ZU FRAGEN VON OPEN ACCESS UND OPEN SCIENCE informiert regelmäßig Forschende, Studierende sowie die interessierte Öffentlich- keit über den gegenwärtigen Strukturwandel der Wissenschaftskommunikation organisiert u.a. Beratungsangebote zum wissenschaftlichen Publizieren, Workshops zum Forschungsdatenmanagement und Gastvorträge zu Open Science-Themen engagiert sich mit ihren | poster |
COOPERATION POSTER CREATORS “Retro-editing” : The edition of an edition of the Karl Kraus legal papers IN THE PROJECT “INTERTEXTUALITY IN THE LEGAL PAPERS OF KARL KRAUS. A SCHOLARLY DIGITAL EDITION”, THE LEGAL PAPERS OF THE AUSTRIAN SATIRIST KARL KRAUS (1874- 1936) ARE BEING EDITED AND WILL BE PROVIDED DIGITALLY AND CONTEXTUALIZED WITH KRAUS’ OEUVRE AS A WHOLE. IN THIS POSTER, THE DIGITIZATION AND EDITING PROCESS OF THE PROJECT ARE DESCRIBED. AS THE PRECONDITIONS OF THIS DIGITAL EDITION ARE QUITE UNIQUE, THE POSTER FOCUSES ON THE PROJECT’S SPECIFIC INITIAL SITUATION, THE AVAILABLE MATERIAL, AND ITS PROCESSING AS WELL AS ON THE AIMS, GOALS, AND THE INTENDED OUTCOME (I.E. THE PLATFORM PROVIDING ACCESS TO THE DIGITAL EDITION) OF THE PROJECT. Vanessa Hannesschläger Austrian Centre for Digital Humanities / Austrian Academy of Sciences vanessa.hannesschlaeger@oeaw.ac.at INTERTEXTUALITY IN THE LEGAL PAPERS OF KARL KRAUS : A DIGITAL SCHOLARLY EDITION FWF project no. P 31138-G30 Introduction: Historical context While the Austrian Karl Kraus (1874-1936) is most commonly perceived as a satirist, writer, and editor of the magazine Die Fackel, his intensive preoccupation with justice was often observed and Walter Benjamin even declared: “No one will understand this man, unless one realises, that everything, without exception, language and purpose, for him happens in the sphere of law.”[1] Although Kraus’ attitude towards the courts in the Habsburg period had been predominantly critical, the constitutional reform of the Austrian Republic in 1919 and the abolition of death penalty marked a decisive break for the author. He especially welcomed the reform of the Press Law of 1922, which marked the beginning of a growing fondness for litigation. In the same year, Oskar Samek became his lawyer. In the course of the following 15 years (until Kraus’ death), they were involved in over 200 court actions together. Despite of Kraus’ commitment to the law, the influence legal proceedings had on his satire and the other way round was barely thoroughly researched – which was on the one hand due to the fact that cultural and literary historians often shy away from the interpretation of legal documents. Only Reinhard Merkel, a professor of criminal law, attempted to understand the connection of “Strafrecht und Satire” in Kraus’ Fackel from a jurisprudential point of view.[2] The second reason for the lack of research in this area is that the complex history of the Kraus papers, which were split up into several personal collections and taken to exile by Kraus’ (often jewish) friends and associates when they were forced to leave Austria during the time of the Nazi regime, was responsible for the long- lasting unavailability of the material documenting Kraus’ involvement with the law. The project described in this paper aims to bridge this gap by (re-)editing the papers documenting Kraus’ and Samek’s actions and making them available in an open access / open data / open source digital edition. Karl Kraus and Oskar Samek in court. The Kraus legal papers at the Vienna City Library. Initial position and starting point The material documenting Kraus’ and Samek’s court actions is held by the Vienna City Library. As this corpus consists of roughly 8000 sheets of paper, transcribing and editing all these documents in the course of a three year project with three persons (i.e. full time equivalents) staff would be unfeasible. Luckily, transcription is only a minor part of the project members’ tasks: In 1995, Hermann Böhm published the records of cases from the Karl Kraus papers as a ‘mixed edition’ (“Mischedition”) in four volumes[3] (of roughly 300 pages each). However, Böhm made a number of editorial decisions which are today out of date and not suited for a digital format, which is why a new edition of this material has become a desideratum among Kraus researchers as well as a wider research community interested in historical legal documents. While Böhm did a trem | poster |
Implementation of the “Essential-use” concept in chemical regulations Romain Figuièrea, Zhanyun Wangb, and Ian T. Cousinsa a: Department of Environmental Sciences, Stockholm University, SE-10691 Stockholm, Sweden b: Empa – Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland • Derogations refer mainly to the “availability of alternatives” component of the essential-use concept. • Category “Others reasons” can be divided into two sub-categories: • Reasons for which the essential-use concept would not affect the regulatory outcome, i.e., because the use already regulated, the use being out of scope, restriction not enforceable for the specific use, or substance found as impurities in the specific use; • Reasons for which the essential-use concept could affect the outcome, i.e., because negligible risk from the use, or the restriction costs outweigh the benefits, mentioned for ~20% of the derogations. Results Acknowledgements This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101036756. Partners Background Methods In the Montreal Protocol, a use is essential only if (A) it is necessary for the health and safety, or is critical for the functioning, of society; and (B) there are no available safer, technically and economically feasible alternatives. The EU Chemicals Strategy for Sustainability stipulates implementation of the essential-use concept under REACH to guide phase-out of the most harmful substances. Aims of the study To determine (1) whether the existing restriction of uses of harmful chemicals processes refer to elements of the essential-use concept; and (2) whether process changes are necessary to implement the concept in the decision-making. Analysis of the decisions on derogations to restrictions under Stockholm Convention and REACH processes following the READ approach (Dalglish et al. (2020)) to determine if relevant information to perform essential-use assessment was available. Lessons-learnt • No major changes in the REACH Restriction process are needed to implement the essential-use concept. • Previous decisions on derogations have been mainly based on the availability of alternatives. • The essential-use concept can bring a new perspective in decision- making. Components of the essential-use concept mentioned in decision-making on derogations to previous restrictions *: See separate section on REACH Authorisation process References: EU (2020), https://ec.europa.eu/environment/pdf/chemicals/2020/10/Strategy.pdf; Dalglish et al. (2020), DOI: 10.1093/heapol/czaa064; EU (2024), https://environment.ec.europa.eu/publications/communication-essential-uses-chemicals_en Contact romain.figuiere@aces.su.se REACH AUTHORISATION PROCESS • Authorisations are granted if (1a) risk is adequately controlled, or (1b) costs of ceased use outweigh the benefits, and (2) there no suitable alternatives available to the applicant (“Availability of alternatives” component) • Further work is needed to determine if enough information is provided in the applications to evaluate if the technical function is needed in final products, and whether it would fulfil the criteria to be considered as necessary for society • For 20 applications, the European Commission did not grant authorisation for part of the use applied for where “the specified key functionality is not necessary for the use” (“Technical function” component) Is the technical function needed in the final product? Technical function Does the use fulfil one of the criteria for being critical for society? Necessity for society Are acceptable alternatives lacking? Availability of alternatives Overview of the assessment of essentiality of a use as proposed by the European Commission 2% 15% 58% 40% 8% 15% 31% 88% 5% 100% 100% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Technical function Necessity for society Availability of alternatives Other reasons REACH Authorisa | poster |
1Departamento de Física de la The lithium-age relation: Calibration with open clusters and associations Acknowledgments: Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme focus ID 188.B- 3002. These data have been obtained from the GES Data Archive. This work has made use of data from the European Space Agency (ESA) mission Gaia. We acknowledge financial support from the Universidad Complutense de Madrid (UCM) and by the Spanish Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, from project AYA2016-79425-C3-1-P and PID2019-109522GB-C5[4]/AEI/10.13039/501100011033. Dependence with rotation, activity and metallicity. Li-age relation Candidate members for each cluster are selected from the Gaia-ESO Survey (GES) (Gilmore et al. 2012) iDR6 data based on the following criteria: RVs, Gaia astrometry (proper motions and parallaxes), gravity indicators - Kiel (logg vs Teff) and 𝛾 index diagrams -, [Fe/H] metallicity, and the position in the EW(Li) vs Teff diagram. As an example we show here the case of IC 2602 (PMs, CMD, EW(Li) vs Teff and 𝛾 index) and NGC 6705 (RV, Kiel diagram and [Fe/H] histogram): Selection criteria and cluster membership Abstract EW(Li) vs Teff: Plotting the lithium envelopes of IC 2602 (35 Myr), the Pleiades (78-125 Myr), and the Hyades (750 Myr) in a EW(Li) vs Teff figure, we can estimate age ranges and verify probable members (see Montes et al. 2001). Kinematic selection: We studied the RV distribution of each cluster by applying a 2-sigma clipping procedure and adopting a 2σ limit about the cluster mean yielded by the Gaussian fit to identify the most likely RV members. The Kiel diagram enables us to discard giant outliers (logg < 3.5) – some of them Li-rich giants (A(Li) > 1.5) – and other field contaminants. We used the PARSEC isochrones (Bressan et al. 2012), with Z = 0.019 and ages ranging from 1 Myr to 7 Gyr. For young clusters, we used the gravity indicator gamma (see γ index vs Teff diagram above) to discard giant contaminants before applying any kinematic and astrometric criteria. XI Reunión Científica de la SEA 5-9 September 2022, La Laguna [Fe/H] histograms also help rule out stars with metallicities too far away from the mean for each cluster. M.L. Gutiérrez Albarrán1, D. Montes1 , H.M. Tabernero1,2, J.I. González Hernández3,4, A. Frasca5, A.C. Lanzafame5, R. Smiljanic6, A.J. Korn7, S. Randich8, G. Gilmore9, et al. & GES Survey Builders In this work we used a series of open clusters and associations observed by the Gaia-ESO Survey (GES) to study the use of lithium abundances (Li I spectral line at 6708 Å) as an age indicator for pre- and main-sequence FGKM late-type stars. Previous studies of open clusters have shown that lithium depletion is not only strongly age dependent, but also shows a complex pattern with several other parameters, such as rotation, chromospheric activity and metallicity. Using the available data from both GES iDR6 and Gaia EDR3, we performed a thorough membership analysis and obtained lists of candidate members for 42 open clusters, ranging in age from 1-3 Myr to 4.5 Gyr. We then conducted a comparative study that allowed us to quantify the observable lithium dispersion in each cluster and study the influence of rotation, activity and metallicity in the lithium dispersion of the selected candidates. All this allowed us to calibrate a Li-age relation and create empirical lithium envelopes for 27 of of the 42 sample clusters, also constraining the LDB for those clusters in the 15-600 Myr age range. We used the rotational velocities (vsini), chromospheric activity indicators (EW(Hα)) and [Fe/H] metallicities provided by GES iDR6, as well as additional rotational periods (Prot) from the literature, including Kepler, K2 and TESS measurements. We confirmed the findings of former publications and observed that members with higher values of EW(Li) tend to be faster rotators a | poster |
TEMPLATE DESIGN © 2008 www.PosterPresentations.com • There were 3 cropping rotations in place at St. John: winter pea-winter wheat-spring wheat, cover crop- winter wheat-spring wheat, and fallow-winter wheat- spring wheat. These rotations were replicated so that every crop in each rotation was present in the field. This design was replicated 5 times in the same field. • Crops: winter wheat, spring wheat, winter pea, multi- species cover crop, and a fallow plot. • Sentinel seed station design: medium-sized Petri dish bottoms, filled with plasticine modeling clay with 20 seeds of each species pressed into the clay. • Closed treatment had 0.64 cm hardware mesh cage to exclude rodents and birds. Open treatment had no cage. • There were 4 sampling dates between July 5-Sep 26 2019 and the stations were left in the field for 7 days. • There were 20 replications of fallow, winter pea, and cover crop plots and 60 replications of winter wheat and spring wheat (n = 180). Seed Removal in Pacific Northwest Cereal Production Systems Jessica Kalin*, Sanford D. Eigenbrode* *Department of Entomology, Plant Pathology, and Nematology University of Idaho Introduction Methods Acknowledgements Research Objective: Test these four hypotheses using sentinel seed baits deployed into the replicated trial at St. John, WA. Results References • With projected changes in climate, Pacific Northwest growers are expected to modify their existing cereal- based cropping systems to more resilient, diversified systems. • Diversified systems include more crops, crop rotations, and cover cropping. • These cropping system modifications potentially increase vulnerability to weed and insect pests and this requires research. • Bromus tectorum (downy brome), Chenopodium album (common lambsquarters), and Anthemis cotula (Mayweed chamomile) are common weeds in the Pacific Northwest. [1-3] • “Landscapes in Transition” (LIT) is an inter-disciplinary, multi-institutional Coordinated Agricultural Project focuse on the development and adoption of sustainable and resilient cereal-based production systems in the Inland Pacific Northwest. • As part of LIT, we compared the removal rates by seed predators of these 3 weed species in 5 different crops in an ongoing replicated trial in St. John, WA. Plots at the field site in St. John, Washington. Seed trays placed ~1m apart. This study is part of a large collaborative project, Landscapes in Transition, funded through award #2017-68002-26819 from the National Institute of Food and Agriculture. Special thanks to Grace Overlie and Anna Stutz. Table 1. Partial ANOVA table with weed species, date, crop, treatment, and their interactions. Significant effects listed left. Highlighted effects are reported in detail here. Non-significant effects include: cage, weed species:cage, weed species:date:cage, and weed species:date:cage:crop. [1] Rydrych, D.J. 1974. Competition between winter wheat and downy brome. Weed Science, 22(3): 211-214. [2] Lyon, D.J., Burke, I.C., Hulting, A.G. & Campbell, J.M. 2017. Integrated management of mayweed chamomile in wheat and pulse crop production systems. Washington State University Extension Publications PNW695, pp 106. [3] Bohan, D.A., Boursault, A., Brooks, D.R., & Petit, S. 2011. National-scale regulation of the weed seedbank by carabid predators. Journal of Applied Ecology, 48: 888-898. **All photographs taken by Jessica Kalin unless stated otherwise. • The effects of weed species and crop were significant. The interaction between these effects (p < 0.01) is due to the low rates of lambsquarters seed removal compared to Mayweed and downy brome, especially in fallow. • Removal rates did not differ between open and closed stations (“cage” effect); the cage x crop interaction (p < 0.001) reflects the higher removal rates from caged stations in fallow and cover crop plots than in other crops. This was most evident on week 2 (wk2), accounting for the three-way interaction including date. • Removal of lambsquarte | poster |
We also studied analogous ensembles of hard spinners driven to rotate in opposite directions by an applied torque. The dynamics of the spinners are governed by the Langevin equation. Simulations were performed for 16,384 spinners. References 3. Coarsening dynamics of binary liquids with active rotation2 Bio-inspired colloidal machine: bringing colloids to life S. Sabrina1, A. Brooks1, M. Spellings2,3, S. C. Glotzer2,3,4 and K. J. M. Bishop1 1Department of Chemical Engineering, The Pennsylvania State University, University Park, PA – 16802. 2Department of Chemical Engineering, 3Biointerfaces Institute and 4Department of Material Science and Engineering, University of Michigan, Ann Arbor, MI – 48109. 1. Motivation This work was supported as part of the Center for Bio-Inspired Energy Science (CBES), an Energy Frontier Research Center (EFRC) funded by the U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences under Award # DE- SC0000989. 4. Comparison with microscopic model2 Funding and Affiliations Acknowledgements 5. Current work: shape-directed actuation of spinners The governing equations were solved numerically on a square domain (𝐿× 𝐿) with periodic boundaries using semi-implicit (Adams-Bashforth) Fourier spectral method. The continuum model suggests that activity-induced flows influence the coarsening dynamics depending on the strength of rotation (𝛼) and strength of frictional damping (𝛽). Spinners – converting energy into rotational motion – phase separate via diffusion under strong frictional damping1. 1. Diffusion-controlled passive coarsening is observed for any strength of active rotation under conditions of strong frictional damping (𝛽≫1). 2. Accelerated active coarsening is observed under conditions of weak rotation (𝛼≪1) and weak frictional damping (𝛽≪1). 3. Multi-scale structures emerge under conditions of weak rotation(𝛼≪1) and zero frictional damping (𝛽= 0). 4. Vortex-doublets emerge under conditions of strong rotation (𝛼≫1) and zero frictional damping (𝛽= 0). Vortex-doublet stronger rotation less friction stronger rotation stronger rotation Compositional field Velocity field Domain size 2. Background and continuum model2 spinners 𝑅~ 𝑡1/3 phase separated fluid Assumptions 1. Incompressible, Newtonian fluid 2. Bulk properties (e.g., density ρ, viscosity 𝜂) same in both phases 3. Low Reynolds number 4. Neglect Capillary forces Strength of rotation, 𝛼= 𝜏Ф𝑇𝜂 Strength of friction, 𝛽= 𝑏𝐿2 𝜂 Here,𝜏is driving torque, Ф is equilibrium composition, 𝑇is time of diffusive unmixing over 𝐿, 𝐿is interfacial thickness, and 𝑏is friction coefficient. 1. Nguyen et. al., Physical Review Letter (2014) 2. Sabrina et. al., (submitted 2015) 3. Squires and Bazant, Journal of Fluid Mechanics (2006) 4. Gangwal et. al., Physical Review Letter (2008) 5. Yan et. al., Optical Materials Express (2011). Capture & Convert Move & Transport Sense & Respond Reconfigure & Adapt Heal & Repair Grow & Replicate ‘Life-like’ synthetic materials from colloids Distributed Centralized Vs. Energy conversion into motion Features of distributed actuation • Robust to failure(e.g., muscles) • Intelligent and adaptive behavior(e.g., bacterial swarms) 𝛽= 102 𝛼= 10−2 𝛽= 0 𝛽=0 𝑡= 105 𝑡= 105 𝑡= 105 𝑡= 104 𝑡= 104 𝛼′ = 0.25 𝑡= 105 𝛽′ = 10−2 𝛽′ = 1 𝛼′ = 0.25 Passive Active R i i i i d m dt v F v F (a) Synthesis of different shapes of spinners by photolithography. (b) Selective electroless Ag plating of spinners5 (c) Experimental setup of ICEP-driven spinners. Continuity Convective Cahn-Hilliard Navier-Stokes active driving force frictional damping Induced-charged electro-osmotic flow (ICEO) in ac electric field can actuate particles using their shape asymmetry and surface heterogeneity3. We are synthesizing spinners of complex shape actuated by external fields such as electric and acoustic fields. The design of ICEP-driven spinners of complex shapes is guided by COMSOL simulations. Induced- charge electrophoresis (ICEP)4 Angular velocity of di | poster |
Ophiuchus star-forming region (d ~ 135 pc) 12 Class I sources Herschel colour map Angular resolution: 0.4” (~50 AU) Continuum: 0.87 mm Molecular lines Disk tracers: C17O, H13CO+, C34S Warm chemistry: CH3OH Shock tracer: SO2 ALMA Observations The formation of low-mass stars involves physical and chemical processes that affect the evolution of the disk and set the initial chemical conditions for planet formation [1,2]. However, the physical processes on small disk scales (< 500 AU) are still not well understood [3,4]. How is the envelope material incorporated into the disk? Which physical and chemical processes dominate on disk scales? References: [1] Jørgensen, J. et al., 2008, ApJ, 683, 822; [2] Bergin, E. & Cleeves, I., 2018, haex.bookE, 137B.; [3] Jørgensen J. et al. 2009, A&A, 507, 861; [4] Yen H.-W. et al. 2015, ApJ, 799, 193; [5] Artur de la Villarmois, E. et al. 2019, A&A, 626, 71; [6] Kenyon, S. J. & Hartmann, L. 1995, ApJS, 101, 117. 100 200 300 400 0 3 6 9 12 15 18 21 Tbol [K] Lbol [L⊙] Class I/II Class I Class 0 Decreasing C17O and C18O Colder SO2 No lines on-source C17O SO2 Mass evolution Linear correlation between luminosity and protostellar mass gives Ṁacc = 2.4 ± 0.6 ⨯ 10-7 M⊙ yr-1 for Class I sources [5]. A constant Ṁacc cannot explain the observed luminosities and protostellar ages → Episodic accretion bursts: accretion rate varies with time and the protostar gains a significant amount of material in a short period of time [6]. Chemical evolution Chemical differentiation between C17O and SO2. C17O traces high gas column densities and is detected towards the youngest sources. Warm, compact, and high velocity SO2 emission is related with high luminosities and, therefore, high Ṁacc. ˙Macc = LbolR⋆ GM⋆ Results - A typical protostar will spend most of its lifetime in a quiescent state of accretion. - SO2 may be tracing accretion socks in the envelope-disk interface and highlighting sources with high accretion rates. The formation of disks results in characteristic chemical imprints. Introduction Conclusions The physical and chemical fingerprint of planet-forming disks Elizabeth Artur de la Villarmois* (elizabeth.artur@nbi.ku.dk), Jes Jørgensen, Lars Kristensen, Ted Bergin, Daniel Harsono, Nami Sakai, Ewine van Dishoeck & Satoshi Yamamoto *Niels Bohr Institute & Centre for Star and Planet Formation - University of Copenhagen 0.5 pc | poster |
Mercury Target Neutrinos 24m Baseline Iron Shielding Proton Beam π+ μ+νμ μ+ e+νμ νe K+ μ+νμ 17 Tons GdLS 30 Tons LS Veto IBD νe+p → e++n n+Gd → Gd+γ Prompt Delayed,𝜏≈28μs 96 inward looking 24 outward looking 120 10-inch PMTS J A N U S J A N U S J A N U S J A N U S J A N U S F O N T U S Large PMT Pulse Single PE PMT Pulse Custom Analog Proto-board TI ADS54J66 ADC Eval Board Analog & ADC Proto-board Xilinx Kintex Ultrascale Dev Board JANUS PCB design is complete JANUS : 32 Channel DAQ Board ... ... ATCA Backplane Global Bus PMT Data (Ethernet) Energy Sum (Serial 10Gbps) SFP+ Global Trigger Energy Sum (Serial 10Gbps) SFP+ PMT Data (Ethernet) Process Data and Triggers Digital (Serial) FPGA 1 Xilinx Kintex Ultrascale JESD204B FPGA 0 Xilinx Kintex Ultrascale 32 PMT Channels Analog Differential Signals Condition the PMT Signals Digitize the Waveforms ADC 7 500 MHz, 14-bit ADC 0 500 MHz, 14-bit ADC 3 500 MHz, 14-bit Frontend Analog Transceiver Transceiver Global Clock ADC 4 500 MHz, 14-bit FONTUS : Trigger Board FPGA Xilinx Kintex Ultrascale ATCA Backplane Energy Sum (Serial 10Gbps) Clock Front Panel Beam Signal External Triggers Global Trigger Global Bus Trigger Info (Ethernet) J A N U S J A N U S J A N U S J A N U S J A N U S F O N T U S 104 105 106 107 Neutrino Flux (Arb.) µ π K -600 -400 -200 0 200 400 600 800 1000 Time (ns) 0 20 Current (A) ×25Hz Beam Pulses Process Trigger Data to Produce Triggers Proto-board that can emulate both JANUS & FONTUS functionality is being produced. Pending testing and production of the final JANUS & FONTUS PCBs commissioning of the DAQ will begin Fall 2020. Once this design has been sucessfully deployed for JSNS2 we hope to demonstrate this as a "one size fits all" DAQ solution for medium- scale liquid scintillator detectors. The 14-bit resolution & large dynamic range provides sensitivity to high energy neutrinos, e.g. KDAR neutrinos, without losing single- PE sensitivity. The upgrade DAQ will be hosted within an ATCA shelf with 5 DAQ boards (JANUS) and one trigger board (FONTUS). Design can be expanded to fit possible future needs. Tests of the analog circuitry have demonstrated its ability to produce a differential copy of the input with excellent signal integrity. The FPGA based trigger allows event selection based on known event timing relations and the flexibility to design trigger logic specific to the physics of interest. Expected data readout rate is 1 Gbps per FPGA. The electronics will need to trigger based upon timing signals from the beam facility as well as event energy and timing conditions. Our system will leverage modern FPGA and telecom electronics to meet these requirements. The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) began taking data with DAQ electronics donated by the Double Chooz experiment. The Double Chooz electronics, however, were not designed for a beam based experiment and are not sensitive across the entire energy range of interest for JSNS2. I have been working, as part of a team, to develop upgrade electronics that will be better suited to JSNS2's energy and timing requirements. The upgrade electronics will enhance our physics capabilities by providing a excellent efficiency and resolution over a large energy range. Firmware testing and development underway using commercial and custom bench-top electronics. Beam Neutrino Production: Spectrum & Timing JSNS2 Detector & Primary Physics Interactions The Benefit of 14-bit Resolution The Design and Development of the JSNS2 DAQ Upgrade Eric Marzec (marzece@umich.edu) For the JSNS2 Collaboration JSNS2 Design Development | poster |
Fabrication of Lightweight Aluminium Metal matrix composites and validation In Green Vehicles FLAMINGo is a H2020 project funded under the LC-GV-06-2020 topic, aiming to the development of high-performance lightweight Aluminum composite materials thanks to a novel metallurgical and forming combined approach for making automotive parts. The FLAMINGo Project aims to manufacture strengthened Aluminium Metal Matrix nano-Composites, Al-MMnC, with enhanced properties in terms of strength and stiffness, compared to the existed Al alloys used in Green Vehicles. Nanoparticles & AI masterbatches Topology Optimisation Foundry Primary & Secondary Aluminium LCA/LCCA SAFETY LPDC, HPDC, GSC, DC Extrusion FieldTest Recycling WEIGHT SAVING REDESIGN LIGHTER ENGINE SMALLER BATTERY PACK THE PARTNERS THIS PROJECT HAS RECEIVED FUNDING FROM THE EUROPEAN UNION’S H2020 PROGRAMME UNDER THE GRANT AGREEMENT NO. 101007011 @FLAMINGoProjectH2020 @FLAMINGoPH2020 @FLAMINGo Project H2020 info@flamingo-project.eu www.flamingo-project.eu CONNECT WITH US | poster |
Objective TERMINUS addresses the challenge of unlocking the recycling and reuse of flexible multi-layer and multi- compound packaging through the design of new formulations with smart enzyme-containing adhesive or tie layer polymers. After a specific trigger, the enzyme will start degrading the polyurethane-based adhesive (PUR) or tie layer (TL), thus enabling the delamination of the different layers of packaging, which can then be recycled. Multilayers packaging recycling: the Terminus strategy TERMINUS has received funding from the European Union’s Horizon 2020 research and innovation programme, under grant agreement number 814400. This presentation refects only the views of the authors. European commission and Research Executive Agency are not responsible for any use that may be made of the information it contains. A. Romano, G. Totaro, A. Celli, C. Gioia, N. Raddadi, G. Zanaroli, L. Sisti Dept. of Civil, Chemical, Environmental and Materials Engineering, Alma Mater Studiorum Background Multi-layer packaging films are largelyexploited in the food industry, because they extend the lifetime of goods, helping to reduce food waste, but due the multi-material structure, these material are unrecyclable and currently 100% of multi-layer packaging is incinerated or landfilled, only for beverage cartons recyclability is demonstrated in practice and at scale. in-built Triggered Enzymes to Recycle Multi-layers: an Innovation for Uses in plastic-packaging SELECTION IMMOBILIZATION and TRIGGERING INCORPORATION Strategy of the hybrid systems into the adhesives of enzymes of the most active enzymes for adhesives 15% improvement in economic efficiency of end-of-life management 80% reduction of landfilling for multi-layer plastic packaging 55% reduction of overall plastic landfilling 65% decrease in the overall CO₂ footprint Expected Results | poster |
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 824603. @ACTION4CS #ACTION4CS https://actionproject.eu Participant motivation to engage in a citizen science campaign: the case of the TESS network Gloria Re Calegari (Cefriel - gloria.re@cefriel.com), Irene Celino (Cefriel - irene.celino@cefriel.com), Mario Scrocca (Cefriel - mario.scrocca@cefriel.com), Jaime Zamorano (UCM - jzamorano@fis.ucm.es), Esteban González Guardia (UPM - egonzalez@fi.upm.es) The contents of the poster reflects the author’s views. The European Commission is not liable for any use that may be made of the information contained therein. Survey design • define the research question • define investigated factors • formulate questions • set-up the questionnaire • test the survey with some user Survey administration • identify list of respondents • send survey • re-solicit responses, if necessary Collect & Process survey responses • monitor answer collection • export data • process data Interpret & Share survey results • draw insights from result analysis • anonymizing data if needed • select suitable open licenses • openly publish research results (e.g. as research objects) Research question Collect & Process survey results Survey administration Link of the survey sent by email to 120 people hosting photometers. One reminder after a week from the initial sending. 83/120 volunteers answered the survey (69%) 2 Survey design Selection of investigated factors • Reference methodology inspired by the Schwartz Theory of Basic Values1 • 10 motivating factors related to instinsic motivation that may influence CS global motivation (self-direction, stimulation, hedonism, achievement, power, conformity, benevolence, universalism, routine and belongingness) Questions formulation • 2 closed questions for each motivating factor (answers values from 1 to 5) • 1 closed question for global motivation (answers values from 1 to 5) • 1 open question for free text motivation • 10 questions for demographics and data usage Total: 32 questions TESS network initiative aims to collect sky brightness measurements through sensors to fight light pollution Telescope Encoder and Sky Sensor (TESS-W) photometer is a compact and inexpensive device developed under STARS4ALL project by the Universidad Complutense de Madrid As of today, 200+ TESS photometer hosted by 120 people in Asia, Africa, North and South America, Europe and Australia (sensors displayed on this map https://tess.dashboards.stars4all.eu/) Citizen Scientists mainly involved in data collection task. No monetary rewards for participants. Interpret & Share survey results The survey structure, the collected answers and the analysis of correlation are openly available in RDF and CSV formats on Zenodo https://zenodo.org/record/3739058#.XxcK1udS9PY. Reproducibility and Open Science. This survey can be reused to study motivation in other CS communities. Contact us to have support on this! The TESS Network community Demographic In your own word, which is the main motivation why you decided to host a photometer? How much are you motivated in participating to the TESS Network? Global motivation Motivating factors 85% are male, 70% of volunteers are older than 45 years old Which of the following categories identifies you the most? What are you using (or planning to use) the data provided by your photometer for? 75% interested in downloading, exploring or using data collected from all the sensors installed, but only 30% has evidence about data usage by researchers. Learning about the project discoveries has in itself been framed as a reward. Increasing the sharing of the results can be an added value for the community. Factor Mean Answers Correlation with global motivation Questions Self-direction 4,43 0.491*** want to learn interested in topics Benevolence 4,42 0.62*** good thing to do contribute and help the scientific research Universalism 4,33 0.672*** | poster |
IPM strategies against Drosophila suzukii (IPMDROS) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 130,000 Picture 1 Picture 1 Picture 1 Goals The goal of the project is to participate to the development of IPM programs for the control of D. suzukii , that are of great importance to reduce the huge economic impact that this fly can potentially exert on European agriculture Research consortium ES-INIA; TR-GDAR, AT-AGES; IT-CRA; BE- ILVO Contact information Project coordinator: Ismael Sánchez Ramos ismael@inia.es Key outputs and results The expected results of the project are: • A temperature based model including parameters such as mortality of immature stages, developmental rate of immature stages, reproduction, longevity of adults, life table parameters for the prediction of risk situations, possible new areas of colonization and number of generations per season to be implemented in an IPM approach for the control of D. suzukii. • A basic data survey about the cold tolerance and overwintering strategies of European populations of D. suzukii to determine which European countries are at risk of D. suzukii establishment. • Improved reliable and easy to handle trapping devices for monitoring and population reduction of D. suzukii. • Evaluated selective insecticides with different mode of action (e.g. IGRs) and alternative plant protection products including entomopathogenic microorganisms for the control of D. suzukii to increase the available alternative control methods for IPM programs. • Surveys and protocols for early detection of D. suzukii in non-invaded countries. Objectives Objectives are •To improve of basic knowledge about the biology of the fly, including overwintering behaviour and effect of temperature on development, reproduction and population increase. •To develop of effective trapping systems for population reduction •To evaluate alternative methods for control, such as insect growth regulators and entomopathogenic microorganisms. •To monitor surveys for early detection and development of quarantine measures and effective surveys of goods in global trade among countries 07/2014-12/2016 | poster |
Zielgruppe Wir schaffen eine bedarfsgerechte Infra- struktur für die Forschungsdaten unserer Communities von der Architektur-, Kunst- und Musik- bis hin zu Theater-, Tanz-, Film- und Medienwissenschaft. Struktur Dienste Ressourcen Helpdesk KONSORTIUM FÜR FORSCHUNGSDATEN ZU MATERIELLEN UND IMMATERIELLEN KULTURGÜTERN NFDI4Culture strukturiert sein Arbeitspro- gramm entlang des Forschungsdatenlebens- zyklus in sechs operative Aufgabenbereiche. Ein siebter umfasst alle Prozesse, die Administration und Kommunikation. Unser übergeordnetes Ziel sind die Registrierung und die Verbesserung bestehender Dienste sowie die Entwicklung neuer Dienste für das Forschungs- datenmanagement. In unserer Knowlege Base stellen wir Handreichungen zur Verfügung, kuratierte Findmittel, Berichte, Videotutorials und daneben auch technische Schnittstellen zu Forschungsdaten. Der NFDI4Culture Helpdesk berät zu allen Fragen rund um das Management von Forschungsdaten in allen Phasen des Daten- lebenszyklus. Spokesperson und Hosting Institution 55131 Mainz Prof. Torsten Schrade Akademie der Wissenschaften und der Literatur | Mainz Geschwister-Scholl-Str. 2 Kontakt Mastodon: https://nfdi.social/@nfdi4culture https://nfdi4culture.de contact@nfdi4culture.de Abb. v.o.: Mittelalterliche Glasmalerei: Jüngstes Gericht, Weltgerichtsfenster im Dom Eichstätt, Andrea Gössel, CC BY-NC 4.0; Illustration des NFDI4Culture Arbeitsprogrammes, Sarah Pittroff, CC BY 4.0; Business boy with rocket, A.J. Rich; AI Human Brain Processor Circuit, 13FTStudio; Vintage styled rotary phone with help sign on a white background, Doomu. | poster |
The Impact of Living with Spinal Muscular Atrophy in Malaysia from Patients’ and Caregivers’ Perspectives. Karina Koh1 , Azlina Ahmad Annuar2, Fahisham Taib3, Koh Cha Ling4, Edmund Lim Soon Chin5 , Ch’ng Gaik Siew6 1Clinical Research Centre, Hospital Kuala Lumpur, 2Department of Biomedical Science, Faculty of Medicine, University of Malaya, 3Department of Paediatrics, Hospital Universiti Sains Malaysia, 4HELP University, Kuala Lumpur, 5Persatuan Kebajikan Ceriajaya Kuala Lumpur Dan Selangor (WeCareJourney), 6 Genetics Department, Hospital Pulau Pinang. NMRR-18-3248-42367 Introduction: Spinal Muscular Atrophy (SMA) is a recessively inherited neuromuscular disorder caused by deletions or mutations in the survival motor neuron 1 gene (SMN1). Estimated incidence rate in Malaysia is 1 in 20,000 population with 25-50 babies born annually.¹ The clinical type of SMA is defined by the age of onset and severity of the disease, from type 0 to type 4. 2 Currently, there is no cure for SMA, but disease modifying therapies can delay disease progression. There is a lack of knowledge on SMA amongst the public and even healthcare providers, which may impact the perception of the disease and its proper management. This study aims to explore the impact of SMA on the lives and daily activities of SMA patients and their caregivers. Methods: This was a mixed method cross-sectional study consisting of; Conclusion: This study, to the best of our knowledge represents the first comprehensive study on SMA in South East Asia, highlights a plethora of issues and challenges experienced by PWSMA and their caregivers in Malaysia, from the point of SMA diagnosis and throughout the management of care, in addition to the deep psychosocial impact of living with SMA. Their voices will help to inform stakeholders of areas of improvement needed in clinical practice, the education system and the society at large. Results: A total of 42 individuals participated in the quantitative survey, of whom 13 were persons with spinal muscular atrophy (PWSMA) and 29 were caregivers. After completing the survey, 7 PWSMA and 23 caregivers proceeded with the interview sessions. Table 1 summarizes the sociodemographic and characteristics of the participants. The impact of living with SMA are as shown in Table 2. The findings from the FGD and IDIs are summarized in Table 3. Characteristics PWSMA N = 13(%) Caregivers of PWSMA N = 29(%) Gender Male Female 5(38) 8(62) 11(38) 18(62) Ethnicity Malay Chinese Indian Others 7 (54) 5 (38) 1 (8) 0 22 (76) 5(17) 1 (3) 1 (3) Age (years) 10-19 20-29 30-39 40-49 50 and above 2 (14) 9 (69) 1 (8) 1 (8) 0 - 2 (7) 10 (34) 9 (31) 8 (28) SMA Type Type 1 Type 2 Type 3 0 (0) 9 (69) 4 (31) 8 (28) 11 (38) 10 (34) Table 1: Characteristic of participants Table 2: Impact of living with SMA Physical & psychosocial impact of SMA PWSMA N = 13 (%) Caregivers of PWSMA N = 29 (%) Feel stressed 7 (54) 16 (55) Feel depressed 5 (38) 6 (21) Feel anxious 5 (38) 22 (76) Feel socially isolated 4 (31) 3 (10) Unable to self transfer 7 (54) 17 (59) Unable to turn in bed 5 (38) 11 (38) Unable to manage personal hygiene 4 (31) 15 (52) Unable to attend work/school 4 (31) 8 (28) Limited social activities 4 (31) 6 (21) Unable to feed oneself 3 (23) 5 (17) Discussion: This study has initiated an important step in raising the voices of PWSMA and their families, by highlighting a number of issues and their unmet needs. The journey from diagnosis to managing their daily lives is fraught with frustrations and anxiety similar to the findings of Qian et al. ⁴ The psychosocial impact of SMA also echoes a study conducted in Denmark where all the adult PWSMA lived with anxiety and fear of progressive motor decline.5 Moving forward, there is a need for a multidisciplinary team to provide a holistic care from diagnosis to treatment, rehabilitation, and psychosocial support. Transdisciplinary collaboration and open communication between all the stakeholders of various specialties focusing on | poster |
SSHOC social sciences & humanities open cloud “Social Sciences and Humanities Open Cloud”, has received funding from the European Union’s Horizon 2020 project call H2020-INFRAEOSC-04-2018, grant agreement #823782 How does this thematic SSH Marketplace connect to the EOSC? How will the Marketplace advance SSH and cross-disciplinary research? SSHOC social sciences & humanities open cloud A Marketplace for the Social Sciences and Humanities 1. Contextualised solutions Through a process-oriented approach, centred around the research workflows, the SSHOC Marketplace contextualises interrelated datasets, tools, and services with tutorials, links to training material, user stories, showcases, and other relevant information. Interoperability will be achieved via the Data and Metadata Interoperability Hub being developed within SSHOC. Input For: 2. Modelling the EOSC Federating Core SSHOC Marketplace aims to make use of EOSC Federating Core, especially the Federated Identity (AAI) services and the Helpdesk. Views on common themes will also be exchanged and harmonised with other European and international organizations operating in the EOSC. Specific attention will be paid to the OpenAire initiative and its catalogues. Input For: 3. Bridging EOSC and the SSH community Like EOSC itself, the SSHOC Marketplace is being created and shaped by and for the research communities. The participating research infrastructures have defined the state of the art and user requirements through multiple exchanges with the SSH community using Agile and User Centred Design approaches. Input For: Context Related materials such as code or data are linked, providing additional context Support Users have access to appropriate training materials for their use of tools Community With the inclusion of user feedback or ratings, the Marketplace is a “Stack Overflow” for the SSH Gap analysis With all resources gathered in a central repository, it will be easier to identify tools that don’t exist and should be developed to address specific needs Sustainability A focus on curation and information quality, and the creation of a sustainable governance model and user community ensure the durability of the Marketplace over time Serendipity Users find useful information they hadn’t thought to look for! Join our Community K sshopencloud.eu t @SSHOpenCloud l /in/sshopencloud “ The SSHOC Marketplace is the only fully-integrated discovery portal which pools and harmonises the tools and services useful for the SSH research communities, offering a high quality and contextualised answer at every step of the research data life cycle. info@sshopencloud.eu ✉ SSHOC Partners Read the System Specification for the SSH Open Marketplace Timeline January 2019 Launch of the SSHOC project June 2020 1st release of the SSH Marketplace December 2020 2nd Release of the SSH Marketplace December 2021 Final Release of the SSH Marketplace April 2022 End of the project | poster |
COAR - Confederation of Open Access Repositories: Reaching out to global interoperability through aligning repository networks Kathleen Shearer, COAR Executive Director, kathleen.shearer@coar-repositories.org Maxie Putlitz, COAR Office, office@coar-repositories.org Katharina Müller, COAR Office, office@coar-repositories.org COAR, the Confederation of Open Access Repositories, is a dynamic association of repository initiatives launched in October 2009, uniting roughly 100 members and partners from 35 countries from throughout Australia, Africa, Asia, Europe, Latin America, and North America. The association aims to enhance greater visibility and application of research outputs through global networks of Open Access digital repositories. Activities of COAR members and partners are undertaken in working and interest groups as well as task forces. Work areas range from repository content, global interoperability, over education and training to monitoring new trends and developments in the open access repository community. This poster will outline COAR’s latest activities in order to inform the broader repository community and promote greater collaboration with others. COAR is an international organization based in Goettingen, Germany. The association acts as forum to learn about new trends; engage with international colleagues in the repository community; and ensure repositories adhere to global best practices and interoperability standards. COAR also actively promotes the role of repositories within the broader scholarly ecosystem and works with other actors to ensure alignment of services and infrastructure globally. Members and partners come together once a year in a general annual meeting to discuss important developments of the association and in the repository community. COAR has undertaken several activities over the last year to foster global repository interoperability through the initiative “Aligning Repository Networks”. In this initiative several major international organizations joined together to underscore their support for immediate open access to research articles and aim for harmonized standards and common vocabularies. A petition has been set up which is still open for endorsements. Moreover in early February 2015 the Interoperability Working Group published the COAR Roadmap: Future Directions for Repository Interoperability. The roadmap identifies important trends and their associated action points for the repository community and will assist COAR in identifying priority areas for our interoperability | poster |
HIGH-THROUGHPUT YEAST SCREENING REVEALS A NEW DIMENSION OF INTRACELLULAR PATHOGENESIS. Malene L. Urbanus2, Harley O’Connor Mount1, Eleanor A. Latomanski3, Dylan Valleau4, Frederick P. Roth1,5,6, Hayley J. Newton3, Alexei Savchenko4,7, Alexander W. Ensminger1,2 1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 2. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; 3. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; 4. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; 5. Lunenfeld‐Tanenbaum Research Institute Mt. Sinai Hospital, Toronto, Ontario, Canada; 6. Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; 7. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. WHAT IS A METAEFFECTOR? USING YEAST TO FIND THEM. WHAT’S NEXT? Metaeffectors directly target other effectors HOST TARGET indirect Effectors target host proteins Legionella direct Effectors are proteins delivered to host cells via dedicated bacterial translocation machineries. The intracellular bacterial pathogen, Legionella pneumophila, uses a Type IV translocation system to deliver over 300 effectors to the eukaryotic host cell (~10% of its proteome). The canonical role of effectors is to modify host targets. Metaeffectors (or effectors of effectors) directly modify other translocated bacterial proteins rather than the host. Yin-Yang effectors behave like canonical effectors, but indirectly interact through counteracting modulation of a shared host target. 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 0 20 40 60 80 100 L. pneumophila infects a broad range of eukaryotic hosts (from protozoa to humans) and modulates conserved eukaryotic pathways. Because they target conserved pathways, 37% of L. pneumophila effectors cause a yeast growth defect of ≥20%) when heterologously expressed. Normalized spot sizes of effector-expressing yeast clones grown at 1,536 spot density. Yin-Yang effectors Query (MATα, URA3) Array (MATa, HIS3) Diploid (MATa/α, HIS3, URA3) x sidD (lpg2465) sidM/drrA (lpg2464) query screen Induce expression. Image diploid spot size: ceg3 (lpg0080) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 lpg0081 legA8/ankX (lpg0695) lem3 (lpg0696) 0 1000 2000 3000 4000 spot size (px), replicate 2 0 1000 2000 3000 4000 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sdeB (lpg2156) sdjA* (lpg2508) sidJ (lpg2155) sdbB (lpg2482) sdbC (lpg2391) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), array + query spot size (px), single IDTS lpg1148 legC3 (lpg1701) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 ceg6/pkn5 (lpg0208) ravG (lpg0210) ravJ (lpg0944) legL1 (lpg0945) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 legC7/ylfA lpg2298) mavE (lpg2344) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 lem26 (lpg2523) mavL (lpg2526) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sidM/drrA (lpg2464) sidD (lpg2465) sidL/ceg14 (lpg0437) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 legA11/ankJ (lpg0436) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sdeC (lpg2153) sdjA* (lpg2508) sidJ (lpg2155) 0 1000 2000 3000 4000 spot size (px), replicate 1 mavQ (lpg | poster |
Enabling the research centres of the future - the case of the Platform at the Interface of Science Plataforma de Interface à Ciência (Platform at the Interface of Science) - PIC is a bottom-up Portuguese informal network developed in 2016 by research managers and administrators (RMAs). This community reaches out around 770 RMAs. The added value of PIC in Portugal is based on: • connecting a broad range of professionals in different areas of specialization, such as science communication, data stewards, knowledge transfer valorization, including pre and post- award, • promoting their professionalization, and • working as a partner directly with policymakers and funders in research and development in proposing suggestions focused on the improvement of research systems. Improvement of research systems Community empowerment Broad range of profiles Exchange of best-practices Identification of bottlenecks Policy recommendations The importance of a strong Research Management system Greater awareness of R&I Policies Quality of the scientific production and translation of R&I results Informed decisions and efficient management Improved capacities within the R&I system to conduct open science Consolidation of European Research Area As a community of practice, PIC in the past has developed several initiatives to empower the community, including national events and online sessions of good practices sharing. Its work providing suggestions of improvements to science policy is done in a co-creation exercise with the inputs of the community, using social platforms. PIC organizes regular online meetings to discuss the latest topics on research management and organizes national events focused on the importance and centrality of research management and administration in the ecosystem. Major activities conducted include: - “Cafés Vamos falar de Gestão de Ciência” - Annual events - Recommendations on new national legal frameworks and regulations in Research and Innovation (Lei da Ciência, PL 51/2018; Regulamento do Emprego Científico da FCT) - Suggestions of improvement of specific funding regulations/initiatives Projetos de IC&DT em todos os Domínios Científicos 2017 | poster |
Elements: Software Infrastructure for Programming and Architectural Exploration of Neuromorphic Computing Systems PI: Naga Kandasamy, Co-PI: Anup Das Award #: 2209745 Computing platforms currently used to run machine-learning tasks have high carbon footprint. Neuromorphic computing systems, which mimic biological neurons and synapses can implement these tasks in a highly energy-efficient fashion. Major challenges for neuromorphic computing lie in its adoption by users and from a system developer's perspective, to cope with faster time-to-market pressure for new neuromorphic chip designs. Our project develops a software infrastructure called NeuroXplorer, which allows for Spiking Neural Networks (SNNs) to be mapped onto neuromorphic hardware in the most efficient way possible. It provides: • Compiler backends to generate executable code for neuromorphic chips from a high-level specification of the machine-learning task. • Mapping and synthesis tools to execute machine-learning tasks on novel neuromorphic architectures built using FPGA. • High-performance software for hardware/software design-space exploration of new neuromorphic architectures. Project Motivation NeuroXplorer Infrastructure • Design optimization engine that can incorporate hardware design metrics such as energy, latency, throughput, and reliability, as well as SNN-oriented metrics such as ISI distortion and spike disorder. • System software stack that facilitates mapping of SNN-based applications to different neuromorphic platforms. • Cycle-accurate model of neuromorphic hardware utilizing a generalized template, which can be configured with hardware- and technology-specific details from manufacturers of neuromorphic systems. • Design-space exploration using data-flow models to represent machine- learning tasks executing on neuromorphic hardware which allows key performance metrics such as accuracy and power consumption cost to be estimated early during the design process. • Analysis of different technological alternatives for neuron and synapse circuits, and impact of scaling on neuromorphic hardware, facilitating optimization of key system-level design metrics. FPGAs can serve as accelerators for SNNs, for rapid prototyping, and as the deployment platform. QUANTISENC, a quantized spike-enabled neural core design software in Verilog, enables design and synthesis of SNNs on FPGAs. SONIC: Software-Designed Hardware Methodology SONIC (SOftware-defined NeuromorphIC) is an open-source software-defined hardware design methodology to make neuromorphic computing more accessible. Enables the user to define and train an SNN model using a high-level language such as Python, generate the corresponding register transfer level (RTL) description of the hardware, and create the hardware-software interface to improve programmability when the RTL is prototyped on FPGA and ASIC. • Neuromorphic hardware is configurable via software. • Modular System Verilog testbench to verify QUANTISENC for different learning tasks and datasets. • SONIC is available at github.com/drexel-DISCO/SONIC.git under the MIT license. Contact Information Naga Kandasamy kandasamy@drexel.edu Anup Das anup.das@drexel.edu QUANTISENC: Modular Neuromorphic Hardware Design We have started to integrate SONIC into existing courses to teach neuromorphic computing. • User specifies values for various hyperparameters in the SNN: number of layers, number of spiking neurons per layer, neuronal weights, and internal parameters of the neuron (resting membrane potential, threshold potential, and refractory period). • QUANTISENC allows setting separate quantization and precision policies for synaptic weights and internal state variables to co-optimize area, power, latency, and throughput to achieve a target performance. • Python script generates configuration file for design synthesis along with testbench to simulate/verify functionality of the FPGA design. • Available at github.com/drexel-DISCO/quantisenc-public.git under | poster |
CMBI Introduction The FAIR (Findable, Accessible, Interoperable and Reusable) principles [1] were proposed to guide researchers to describe and share their data to increase data reuse and research reproducibility. Creating FAIR data can be challenging for multi-omics researchers due to a lack of tooling and a diverse landscape of (meta)data standards differing across -omics types. In X-omics [2], we develop a FAIR Data Cube [3] – a set of tools and services that help researchers in different stages of the Research Data Life Cycle including Creation and publish of multi-omics and metadata, Querying multi-omics studies, Analyzing access-protected data. The Implementation and Demonstration of the X-omics FAIR Data Cube XiaoFeng Liao1, Anna Niehues1,2, Martin Brandt3, Tom Ederveen1, Junda Huang1, Purva Kulkarni1,2, Casper de Visser1, Cenna Doornbos1, Joeri van der Velde4, Michael van Vliet5 and Peter-Bram ’t Hoen1 ¹Center for Molecular and Biomolecular Informatics, Radboud UMC, Nijmegen, The Netherlands, ²Translational Metabolic Laboratory, Radboud UMC, Nijmegen, The Netherlands, ³SURF, Amsterdam, The Netherlands, ⁴Genomics Coordination Center and Department of Genetics, University of Groningen and UMCG, The Netherlands, ⁵Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands. Implementation & Demonstration The FAIR Data Cube is being developed in collaboration with the Trusted World of Corona (TWOC) [4] for demonstration. Contact XiaoFeng.Liao@radboudumc.nl Anna.Niehues@radboudumc.nl Peter-Bram.tHoen@radboudumc.nl Acknowledgements NWO, SURF, TWOC. The Netherlands X-omics Initiative is (partially) funded by the Dutch Research Council (NWO), project 184.034.019. no e e ra References: [1]. Wilkinson, M., Dumontier, M., Aalbersberg, I. et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 3, 160018 (2016). [7] https://github.com/Xomics/ISA-ACTION-Template [2]. www.x-omics.nl [8]. https://github.com/ISA-tools/isa-api [3]. https://github.com/Xomics/FAIRDataCube [9]. https://phenopacket-schema.readthedocs.io/en/latest/index.html [4]. https://www.health-holland.com/project/2020/trusted-world-of-corona [10]. https://github.com/Xomics/TWOCdemonstrator/tree/main/tools [5]. Su Y, Chen D, Yuan D, et al. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020;183(6):1479-1495.e20. [11]. https://fdp.combi.umcn.nl [6]. Sansone, SA., Rocca-Serra, P., Field, D. et al. Toward interoperable bioscience data. Nat Genet 44, 121–126 (2012). [12]. https://fdp.cmbi.umcn.nl/blazegraph/ | poster |
1.Problem Statement and Objectives The introduction of DT and digital technologies in organisations has led to a growing trend of skills gap, hence more effective strategies for TD are needed. Objectives - Explore the strategies for TD and DT in the case organization. - Ascertain elements of Leadership and Culture connected to TD and DT - Establish what general theory and practice implications can be learned. 2. Context Heath services in Scotland. A case of NHS Education for Scotland (NES) Talent Development - Comprehensive, inclusive, personalized for individual employee; - Not limited to specific work-related interventions - Includes other development, training and learning. - Benefits both employees and organisations (Hedayati Mehdiabadi & Li, 2016; Rezaei & Beyerlein, 2018 ) Digital Transformation - We digitise information, - We digitalise processes and roles that make up the operations of a business - We digitally transform the business and its strategy (Bloomberg, 2018) 6. Methods 4. Influencing Factors Organisational culture: - Knowledge transfer is promoted - Effective communication between employees - Good rewards system Leadership behaviours: - More people-oriented than task-orientated - Leaders’ concern for employees - Motivate and encourage staff 5. Conceptual map of Themes, Theory, Objectives, and Intended Contributions 3. Main Concepts - Exploratory - Case Study -Qualitative -Semi Structured Interviews References: 1.Bloomberg, J. (2018). Digitization, digitalization, and digital transformation: confuse them at your peril. Forbes. 2.Hedayati Mehdiabadi, A., & Li, J. (2016). Understanding Talent Development and Implications for Human Resource Development: 15(3), 263-294. https://doi.org/10.1177/1534484316655667 3. Rezaei, F., & Beyerlein, M. (2018). Talent development: a systematic literature review of empirical studies. 42(1/2), 75-90. https://doi.org/10.1108/EJTD-09-2017-0076 How can Talent Development be more effective during Digital Transformation? Stella Alhassan b00278519@studentmail.uws.ac.uk Director of Studies: Prof Stephen Gibb Supervisor: Dr Silvio Hofmann Download Poster | poster |
The insect vectors of Xylella fastidiosa (2) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 127 000 Picture 1 Picture 1 Picture 1 Goals Philaenus spumarius plays an important role in the transmission of X. fastidiosa and understanding the biology and behaviour of vectors is vital in controlling the spread of the disease. The project aims to improve knowledge on vectors and potential vectors of X. fastidiosa within differing habitats and climates Research consortium SASA (GB), AGES(AT), ILVO (BE), MPI (NZ), INIAV (PT), NIB (SI), UCL (BE), ULB (BE), IVIA (ES), INRAT (TN) Contact information Project coordinator: Katherine Lester Katherine.lester@sasa.gov.scot Objectives The main objectives of the project are: •To investigate the biology of vectors (and potential vectors) of X. fastidiosa, including feeding preferences and behaviour •To perform transmission studies to determine the efficiency of vectors to transmit X. fastidiosa •To study vector abundance and movement between crops and wild plants •To Investigate traps or lures for collection of Philaenus spumarius •To assess potential biocontrol agents for vectors such as parasites, fungi 03/2021-02/2023 | poster |
I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Experimental Robotic Systems for Design, Development and Testing of Orthopaedic Devices Nicola Sancisi Department of Industrial Engineering University of Bologna 40136 Bologna, Italy nicola.sancisi@unibo.it Michele Conconi Department of Industrial Engineering University of Bologna 40136 Bologna, Italy michele.conconi@unibo.it Vincenzo Parenti-Castelli Department of Industrial Engineering University of Bologna 40136 Bologna, Italy vincenzo.parenti@unibo.it Abstract—The paper presents new robotic systems for test- ing general medical devices. Two applications are presented that show the advantage of experimental tests and articular models in prosthesis optimization and design. Keywords—orthopaedic devices, prostheses, test, robotic rigs I. INTRODUCTION The main objective of orthopaedic devices such as articu- lar prostheses, prosthetic limbs, orthoses and exoskeletons is to replicate or recover the natural behaviour of a joint. This is obtained by a careful design of the mechanical constraints pro- vided by the device, imposing a wanted motion or behaviour of the limb including the device itself. For instance, articular prostheses aim at recovering the joint mobility and stability after substitution of the patient articular surfaces. Thus, pros- thetic components must replicate the natural joint behaviour, reproduce the function of articular structures removed during the implant, and respect the residual structures. To achieve these results, we believe that prosthesis design should be based on a rigorous process combining experi- mental analysis, joint modelling and prototype testing. Exper- imental motion analysis allow definition of the natural joint behaviour at different loading conditions, highlighting the role of each articular structure in constraining the joint motion [1]. Articular models replicate this role in a computational envi- ronment [1,2], where the articular constraints can be substi- tuted by mechanically equivalent counterparts that will con- stitute the basic features of the prosthesis (or the general de- vice). The result of the design process must be built and tested to verify if it satisfies the desired constraints [3,4]. Patient- specific features could be also introduced in the final solution, requiring personalised measures, design and production [4]. The first and the last step of this process consist in the ex- perimental analysis of the joint before and after implant. Be- fore proceeding with clinical studies on patients, these anal- yses can be performed by in-vitro tests on cadaveric speci- mens. Several in-vitro test rigs were proposed, which allow the study of the human joint dynamic behaviour. These de- vices can be divided into two groups: the human joint simula- tors, which aim at reproducing the behaviour of the joint in a physiological way [5], and the robot-based systems [6], which aim at reproducing the loading conditions at the joint by a ro- bot. The main objective of these rigs is to apply given dynamic external loads to the bones, without additional unwanted con- straints. Limitations of most devices currently in use are low flexion ranges, low dynamics and loads, reduced prescribed set of possible tests. The scope of this paper is to describe a family of new test- ing rigs that overcome the present limitations and that are cur- rently used for joint analyses by our group. Two examples and relevant results are included to show successful applications of a “testing and modelling” approach to prosthesis design and optimization. II. TESTING RIGS A. General Feature The testing rigs were designed and built by our labs and show common characteristics. They feature three main parts (Fig. 1, left): a frame (4), a loading system (2, 3, and 11), and a portal (9). The loading system is a six degrees-of-freedom (dof) robot. A first version was a cable-driven robot using six pneumatic actuators, with an inherent force control. | poster |
To boost the green transition, the availability of critical raw materials needs to be ensured. However, the battery sector has been experiencing increasing demand for raw materials for years and is vulnerable for supply risks. METALLICO will: • Recover valuable materials from primary and secondary resources • Demonstrate sustainable production and recovery of (critical) battery metals • Assess end-use of the recovered (critical) battery metals • Identify and characterize (critical) battery metals with innovative technologies • Enable social participation, stakeholder engagement and networking @METALLICO_EU @METALLICO Project * metallico@dechema.de https://metallico-project.eu The primary objective of METALLICO is to develop and validate sustainable and socially responsible recovery strategies for (critical) battery metals and their reuse. METALLICO will develop and optimize five innovative processes to recover the valuable materials needed in the battery industry and in other strategic sectors: Li, Co, Cu, Mn, Ni. METALLICO will demonstrate in four different case studies that the (critical) battery metals can be sustainable produced and recovered by upscaling the five METALLICO processes. Objective 5 Processes 4 Case Studies Demonstration of (critical) battery metals recovery from primary and secondary resources through a sustainable processing methodology. Any dissemination of results must indicate that it reflects only the author‘s view and that the Agency and the European Commission not responsible for any use that may be made of the information it contains. Image source: AdobeStock - 339395914, 406891094, 541126912, 566443983 Coordination: IDENER R&D · Duration: 1 Jan. 2023 – 31 Dec. 2026 Total Project Budget: 13.033.408,00 € · EU Contribution: 11.798.783,25 € | poster |
c ACKNOWLEDGEMENTS CONCLUSION OBJECTIVES BACKGROUND REFERENCES The aim of this systematic review was to measure the impact of daily oral supplementation of vitamin D3 plus calcium on the incidence of hip fracture in older people. METHODS RESULTS THE IMPACT OF DAILY ORAL SUPPLEMENTATION OF VITAMIN D3 PLUS CALCIUM ON THE INCIDENCE OF HIP FRACTURE IN OLDER PEOPLE : A SYSTEMATIC REVIEW Preethy Manoj1 ,Dr .Rosemarie Derwin 2,Dr. Sherly George3 1 Royal College of Surgeons in Ireland, Dublin 2, 2Lecturer, School of Nursing & Midwifery, RCSI, Dublin 2 3 Lecturer & Programme Director, School of Nursing & Midwifery , RCSI, Dublin 2 Hip fractures reduce the quality of life and increase mortality. Osteoporosis is the biggest cause of fracture in older people (Nowson 2010).. It is estimated that by 2025, there will be approximately 28,000 new fragility fracture cases in Ireland costing €320 million (The Irish Times 2018)..The role of Vitamin D3 and Calcium in bone health is well known. The efficacy of daily oral supplementation of calcium plus vitamin D3 on the incidence of hip fracture and non-vertebral fracture in older men and women with or without risk of fracture remain equivocal. This review aims to fill this gap in the understanding. A systematic review with meta-analysis. was carried out. The databases such as CINAHL, MEDLINE, PubMed, Embase, and Cochrane Library were used to search the key terms along with Wiley Online library, HSE online library and Google Scholar. Also, the reference list of the retrieved articles was scanned to identify more studies. The search was conducted from October 2019- January 2020. The Cochrane risk of bias tool was used to check the quality of the included studies. A meta-analysis using Revman 5.3 was used to analyse the data. You probably won’t have any symptoms in early-stage osteoporosis. Once your bones get weak enough, you might start having back pain from fractured or collapsed vertebrae. You may also start leaning forward in a stooped position and measure an inch or two less than before your bone loss. Figure 1 forest plot on the incidence of hip fracture A total of 12,620 older people, both men and women participated in seven RCTs evaluating the impact of combined daily oral supplementation of cholecalciferol and calcium on the incidence of hip fracture in older adults. This review identified a 25% reduction in hip fracture and a 20% reduction in all non-vertebral fractures among older adults who received Vitamin D3 and Calcium supplementation. Vitamin D3 plus calcium supplementation did not show any remarkable increase in the femoral neck bone mineral density. The subgroup analysis identified that daily oral supplementation of 800 IU of vitamin D3 plus 1200 mg of calcium is more effective in reducing hip fracture compared to 800 IU vitamin D3 plus 1000 mg of calcium. The findings of this review serve as a guideline in practice, education, research, and policy. Nonetheless, there is need for well-structured randomised controlled trials evaluating the effectiveness of Vitamin D3 plus calcium on the incidence of hip fracture and other fractures in older people. Nowson, C.A. (2010) Prevention of fractures in older people with calcium and vitamin D. Nutrients, 2(9), pp.975 The Irish Times. (2018) Retrieved from https://www.irishtimes.com/life-and-style/health-family/fitness/the- osteoporosis-time-bomb-1.3425377 on 30/10/2019. 984. I would like to extend my sincere gratitude to the exceptional Staff in the School of Nursing and Midwifery in the Royal College of Surgeons in Ireland whose lectures, guidance and supervision helped me to complete this project. | poster |
Ra Influence of Liquid/Gas ratio and alkalinity on photosynthetic biogas upgrading efficiency in an outdoors tubular photobioreactor David Marín1, Antonio Ortíz2, Enrica Uggetti2, Joan García2, Raquel Lebrero1, Raúl Muñoz1,* 1 Department of Chemical Engineering and Environmental Technology, Valladolid University. * mutora@iq.uva.es 2 GEMMA-Environmental Engineering and Environmental Group, Universitat Politècnica de Cataluña INTRODUCTION • Biogas from the anaerobic digestion of solid wastes constitutes an important energy source able to decrease the dependence on fossil energy in our current society. • The use of biogas as a substitute of natural gas or fuel in transportation requires an effective purification to levels set by international regulations. Biogas injection into natural gas grids typically requires concentrations of CH4 ≥95%, CO2 ≤2%, O2 ≤0.3% and negligible amounts of H2S. • Algal-bacterial processes have emerged as a cost effective and environmentally friendly alternative for biogas upgrading compared to conventional physical/chemical or biological technologies. • Bahr, M., Díaz, I., Dominguez, A., González Sánchez, A., Muñoz, R., 2014. Microalgal-biotechnology as a platform for an integral biogas upgrading and nutrient removal from anaerobic effluents. Environ. Sci. Technol. 48, 573–581. doi:10.1021/es403596m • Marín, D., Posadas, E., Cano, P., Pérez, V., Blanco, S., Lebrero, R., 2018. Seasonal variation of biogas upgrading coupled with digestate treatment in an outdoors pilot scale algal-bacterial photobioreactor. Bioresour. Technol. 263, 58–66. https://doi.org/10.1016/j.biortech.2018.04.117 • Muñoz R., Meier L., Díaz I. and Jeison D. (2015) A review on the state-of-the-art of physical/chemical and biological technologies for biogas upgrading. Rev. Environ. Sci. Biotechnol. 14:727–759 Aknowledgments: This work was supported by the project INCOVER. The project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the grant agreement No. 689242. MATERIALS AND METHODS RESULTS AND DISCUSSION CONCLUSIONS Microalgae BioFertilizer H2S CO2 BioCH4 SO4 2- O2 Solar Energy Digestate Organic Waste Anaerobic Digester Biogas CH4 CO2 H2S Aims of this study: • Study the influence of the liquid/gas ratio on the quality of the upgraded biogas. • Evaluate the influence of alkalinity on the absorption column. Two experimental series were conducted: • During the first experimental series, biogas was sparged into the absorption column (AC) under co-current flow operation in order to evaluate the influence of the liquid/gas ratio (L/G). • During the second experimental series, the influence of the alkalinity on the AC was studied. Biogas was sparged into the AC under co-current flow operation with an addition of a carbonate solution (NaHCO3 and Na2CO3) with a concentration of 16000 mg L-1 of inorganic carbon (IC) Experimental Set-up used for this study Evaluation of the liquid/gas ratio in the absorption column L/G Ratio Liquid Volume (L d-1) Biogas Volume (L d-1) 0.5 50 100 1.0 100 100 2.0 200 100 3.0 300 100 4.0 400 100 5.0 500 100 Evaluation of the influence of alkalinity on the absorption column L/G Ratio IC Concentration (mg L-1) Carbonate Solution (L d-1) 0.5 16000 0 1 2 3 5 The increase in the L/G ratio mediated a higher desorption of O2 and N2, which negatively impacted the final concentration of CH4 in the upgraded biogas. REFERENCES • To the best of our knowledge, this research constitutes the first evaluation of the use of microalgae for biogas upgrading under outdoors conditions at a pilot scale. • This research confirmed the key role of the liquid/gas ratio on the biogas upgrading efficiency. • The results herein obtained confirmed the key role of alkalinity on the biomethane quality. Evaluation of the liquid/gas ratio in the absorption column Evaluation of the influence of alkalinity on the absorption column Liquid Recirculation Pump Biogas Pump External Liquid Recirculat | poster |
COOL STARS 21, Toulouse, France New insights into the rotational evolution of near-solar age stars from M 67 David Gruner1,2, Sydney A. Barnes1,3, and Jörg Weingrill1 1 Leibniz-Institute for Astrophysics Potsdam, Germany 2 University of Potsdam, Germany 3 Space Science Institute, Boulder, CO, USA dgruner@aip.de CONTEXT AND MOTIVATION Gyrochronology allows the derivation of ages for cool main sequence stars based on their observed rotation periods and masses, or a suitable proxy for the latter. It is increasingly well-explored for young FGK stars in open clusters, but few calibrators are available for stars with ages over 1 Gyr, and virtually none for late-K or M-type stars. Our work is aimed at such extensions. LIGHTCURVES FROM THE K2 M 67 SUPERSTAMP Stellar open clusters provide the best environment for related work, because they offer well-defined samples of coeval stars of the same composition. Ac- cordingly, we investigated the hitherto unstudied superstamp created during the Kepler/K2 mission for the 4 Gyr-old benchmark open Cluster M 67. We con- structed a list of cluster stars based on Gaia DR2 and obtained aperture pho- tometry lightcurves for them (cf. panel (a) of Fig. 1). The infamous K2 lightcurve systematics are tamed using a flux correction that models the position depen- dency of the flux (transition to panel (b), same figure), and a Principal Com- ponent Analysis (transition to panel (c), same figure). In the set of lightcurves produced, we identify 39 main-sequence cluster members that exhibit periodic variations ascribed to stellar rotation. 0.96 0.98 1.0 1.02 1.04 Aperture photometry (a) 0.96 0.98 1.0 1.02 1.04 Normalized flux Flux corrected (b) Gaia DR2 604969267746267520 (G −RP)0 = 0.86 mag, G = 17.3 mag PCA 140 150 160 170 180 190 200 210 Time [BJD−2457100 d] 0.96 0.98 1.0 1.02 1.04 PCA corrected (c) One rotation, Prot = 26.0 Double dipping star Figure 1: Lightcurves of a sample star. Panel (a) shows the raw lightcurve from aperture photometry, panel (b) shows the lightcurve after a correction for the telescope jitter, and panel (c) shows the lightcurve after the application of a PCA-based trend correction. ROTATIONAL CLUSTER SEQUENCE OF M 67 We identified rotation periods in stars ranging from the turn-off point (G0) to mid-M stars (blue points in Fig. 2 ). Our data overlap in color range with the sample of Barnes et al. (2016) in the CMD and CPD, and extend it to much later type stars. We find that rotation periods for stars later than mid-K do not show the period increasing uniformly with color that is seen in younger clusters. They instead reach a minimum in period at late-K type before rising again towards the red. Figure 2: Color-Period diagram for M 67. Rotation periods from this work are in blue, while the ones from Barnes et al. (2016) are in orange. The highlighted star is the one shown in Fig. 1. THE BIGGER PICTURE Our M 67 results now confirm what was already suggested by an investigation of the 2.5 Gyr-old open cluster Ruprecht 147 (e.g., Gruner & Barnes 2020, Curtis et al. 2020). 2.5 – 4 Gyr-old stars later than early-K rotate faster than anticipated. This contradicts certain prior pre- dictions and suggests the involvement of a third distinct physical process for an accurate description of rotational evolution. However, our data confirm that cool stars continue to populate a single surface in rotation period-age-mass space until at least 4 Gyr. Furthermore, all three avail- able time steps for older stars (i.e., 1, 2.5, and 4 Gyr, Fig. 3 ) are clearly distinct in rotation period, an essential requirement for gyrochronology. 0.4 0.5 0.6 0.7 0.8 0.9 1.0 1.1 Color (G −RP)0 [mag] 15 15 20 20 25 25 30 30 35 35 Rotation period P [d] This work Barnes et al. 2016 G0 K0 K2 K5 K7 M0 M1 M3 Spectral type References Barnes, S. A., Weingrill, J., Fritzewski, D., et al. 2016, ApJ, 823, 16 Curtis, J. L., Agüeros, M. A., Douglas, S. T., & Meibom, S. 2019, ApJ, 879, 4 Curtis, J. L., Agüeros, M. A., Matt, S. | poster |
GEANT4 rendering of the EDELWEISS cryostat and the detectors. Experimen Due to their small size they have small hea The muon signals are very large and are affected by non-linearities of the TES We fit the muon pulse using a thermal model and extract thermal parameters that affect energy resolution. Development of transition-edge sensor based large area photon detectors for CUPID Vivek Singh, UC Berkeley Neutrino - 2020 (Poster # 97) CUPID: CUORE Upgrade with Particle ID Transition-edge sensors for photon detectors Next generation bolometric search for 0𝜈𝛽𝛽 experiment. CUPID pre-CDR (arXiv:1907.09376) Detector performance V Singh 1, W Armstrong 2, G Benato 1, 3, M Beretta 1, C L Chang 4,5 , B K Fujikawa 3, K Hafidi 2, E Hansen 1, R Huang 1, G Karapetrov 6, Yu Kolomensky 1, 3, M Lisovenko 7,8, L Marini 1, Z Meziani 2, J Pearson 7, T Polakovic 2,6, B Schmidt 3, V Novosad 2,7, K J Vetter 1, S Wagaarachchi 1, G Wang 4, B Welliver 3, V Yefremenko 4, J Zhang 4 1 Department of Physics, University of California, Berkeley, Berkeley, CA. 2 Physics Division, Argonne National Laboratory, Chicago, IL. 3 Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA. 4 High Energy Physics Division, Argonne National Laboratory, Chicago, IL. 5 Kavli Institute for Cosmological Physics, University of Chicago, Chicago, IL. 6 Department of Physics, Drexel University, Philadelphia, PA. 7 Materials Science Division, Argonne National Laboratory, Chicago, IL. 8Nanoelectronics Department, Sumy State University, Sumy, Ukraine • Increase sensitive mass by enrichment • Active background rejection through 𝛼 / (𝛽-𝛾) separation • Goal: ➡△EFWHM ≤ 5 keV @ 2615 keV ➡B = 0.1 c/ton/y in ROI ➡<m𝛽𝛽> ~ 10 meV discovery sensitivity (10 yrs of live time) •CUORE has successfully demonstrated that a ton scale bolometric experiment is feasible. •CUPID will build on the experience of CUORE and use its cryogenic infrastructure. •Li2MoO4 detectors recognized as baseline •Enrichment > 95% •~ 1500 crystals with ~ 250 kg of 100Mo •Demonstrated active background rejection. [see Poster ID 419. on the CUPID-Mo experiment by Benjamin Schmidt] Rendering of CUORE cryostat with 1500 crystals inside it •Dominant background is degraded alphas from surface contamination •Leverage energy loss mechanism in the crystal to tag particle type •Use auxiliary low temperature calorimeter to detect light. Should have High radiopurity Low heat capacity High photon collection efficiency Very low threshold (~ 100 eV) Excellent timing resolution to discriminate the 2𝜈𝛽𝛽 pile up events from 0𝜈𝛽𝛽 events. Particle ID •Low transition temperature with relatively fast fabrication time possible with “bilayers” •Negative electrothermal feedback keeps TES stable and decreases sensor time constant ; faster pulses •Iridium goes superconducting at ~ 140 mK. We use the proximity effect of a normal metal (like, Au and Pt) to reduce the Tc. Device specification: •2” Silicon wafer as optical photon absorber •Ir/Pt (100 nm/60nm) bilayer with Nb traces as electrical leads. •Transition temperature of ~ 37 mK •Sensor dimension 300 𝜇m x 300 𝜇m • We have deposited Au pads, coupling the TES to the wafer for better phonon collection efficiency • Tc relatively unchanged with addition of Au pads but signal-to-noise improves drastically. square Ir/Pt bilayer TES square Ir/Pt bilayer TES in the middle with Au pads on both sides IV characteristics • We can operate the detector down to 10 mK by choosing a suitable bias point. • Due to the steep slope in the biased region, the sensitivity of a TES is much larger than NTD- Ge thermistors (CUORE like sensors) Timing resolution • Generate a train of blue LED light pulse with known separation time >> decay time • Examine distribution of trigger time between the subsequent pulses in detector response • Timing resolution of 𝛥t ~ 5 𝜇s • Detector satisfies the criteria for rejecting 2𝜈𝛽𝛽 pile up events (top) Detector response to train of LED pulses of varying amplitude inj | poster |
Reactivity of oxidising radicals with functionalised surfaces Wolstenholme-Hogg, Amy;a Iqbal, Naeem;a and Chechik, Victora aDepartment of Chemistry, University of York, Heslington, York YO10 5DD U.K. 1 Background 3 Computational modelling 6 Conclusions 1. Ulman A. Formation and Structure of Self-Assembled Monolayers. Chemical Reviews. 1996;96(4):1533-54. 2. De Keer L, Van Steenberge P, Reyniers M-F, Gryn'ova G, Aitken HM, Coote ML. New mechanism for autoxidation of polyolefins: kinetic Monte Carlo modelling of the role of short-chain branches, molecular oxygen and unsaturated moieties. Polymer Chemistry. 2022;13(22):3304-14. 3. Smith LM, Aitken HM, Coote ML. The fate of the peroxyl radical in autoxidation: how does polymer degradation really occur? Accounts of chemical research. 2018;51(9):2006-13. • The studies using mixed monolayers with radical initiators have shown degradation of the neighbouring chains, suggesting autoxidation does occur in monolayer systems. • These findings counteract the kinetic model, which showed no alkane degradation should occur due to the rate of peroxyl radical termination being much higher than H-abstraction by a peroxyl radical. • However, the results support the statistical model which suggest the majority of peroxyl radicals would be too far away from each other to react. Therefore, they can only react with neighbouring organic chains or atmospheric molecules. Non-porous silica nanoparticles have been used as model substrates. Approx. 2.5 molecules/nm2 TGA 0 20 40 60 80 100 120 140 f1 (ppm) 0 50000 100000 150000 200000 250000 i6042c.1.fid AVIIIHD400WB Carbon-13 100MHZ 2.5mm i6042c Amy Wolstenholme-Hogg AWH-C8 20 Solid state 13C NMR Si O O O Silica NPs 10-20nm Radical generation within monolayers Oxidative cleavage of the molecules from the silica surface enables the analysis and quantification of the molecular structures after reactivity by 1H NMR and GC-MS. GC-MS 1H NMR Using 1H NMR and GC-MS, the degradation of neighbouring chains can be monitored to give an understanding of the extent to which radical reactions propagate throughout the monolayer systems after exposure to UV light. The critical step is whether the newly formed peroxyl radicals continue to abstract a H from a neighbouring chain and the propagation of radical reactions occurs or whether they undergo termination to form stable products. Radical propagation Peroxyl termination • Reaction of the sensor surface with an •OH can result in the oxidation of several molecules in the monolayer through autoxidation. • This could increase the sensor sensitivity but also reduce its lifetime. • The aim is to assess the degree of autoxidation – the spreading of radical reactions laterally in the monolayer. 1 2 a a b c c c c b a b c 1) Initiation 2) Reaction with O2 3) Peroxyl radical formation 4) Peroxyl radical termination 4) Radical propagation OR Silica surface 2 Project Aims Functionalisation of silica surfaces •OH 1.8 x10-9 L mol-1 s [2] Statistical model Kinetic model 4 Methodology Dissociation of molecules from silica surfaces Si O Si O Si MeO OMe O O NP surface UV radical initiator (Surface bound) Si O Si O Si MeO OMe N N N N N N N N Thermal radical initiator (Surface bound) Si O Si O Si MeO OMe N N N N N N N N N N N N Thermal radical initiator (Not surface bound) NP surface NP surface UV radical initiation Silica nanoparticles have been functionalised with mixed monolayers of an organic molecule with a radical initiator. Silica surface • Assume 10% of the molecules in a monolayer form active radicals at a given time. • Random generation of 10% points in a grid. Minimum distances plotted as distribution. • 5 molecules/nm2. • Distance between molecules 0.6 nm. • Length of monolayer chains ~0.6 nm • 46% ROO• are close enough to react. • 54% ROO• are more likely to propagate than terminate in monolayer systems. O O O O O O O O F F F F 5 F F F F F 5 F NP surface NP surface NP surface ether alkane perfluoro • Functionalised nanoparticles | poster |
Habitability conditions and radio emission under calm and extreme space weather conditions around Proxima b Luis Pe˜na-Mo˜nino1, Miguel P´erez-Torres1, Jacobo Varela2 & Philippe Zarka3 1CSIC, Instituto de Astrof´ısica de Andaluc´ıa, Granada, Spain 2 Institute for Fusion Studies, University of Texas, Austin, TX 78712, United States, 3 LESIA, Observatoire de Paris, CNRS, PSL, SU/UPD, Meudon, France We acknowledge support through the Severo Ochoa grant CEX2021-001131-S and the Spanish National grant PID2020-117404GB-C21, funded by MCIU/AEI/ 10.13039/501100011033. LPM also acknowledges funding through grant PRE2020-095421, funded by MCIU/AEI/10.13039/501100011033 and by FSE Investing in your future. We also acknowledge the Spanish Prototype of an SRC (SPSRC) service and support financed by the Spanish Ministry of Science, Innovation and Universities, by the Regional Government of Andalusia, by the European Regional Development Funds and by the European Union NextGenerationEU/PRTR. MOTIVATION and GOALS MOTIVATION: • Habitability of exoplanets hosted by M dwarfs drastically depends on space weather. • Main players: ram and magnetic pressure of stellar wind + magnetic field of exoplanet. • Most likely drive radio emission arising close to the planet. GOALS: ▶Characterize habitability of the Earth-like planet Proxima b using 3D MHD simulations. ▷Calm and extreme space weather conditions. ▷Study role of stellar wind and planetary magnetic field, and their mutual orientation. ▶Determine radio emission arising from interaction between the stellar wind of Proxima and the magnetosphere of its planet Proxima b. MHD simulations - We used PLUTO: open 3D magneto-hydrodynamic code Main parameters of the PLUTO simulations Parameter Calm space weather Extreme space weather Sub-Alfv´enic Super-Alfv´enic CME scenario scenario scenario nsw [cm−3] 50 50 250 |vsw| [× 107 cm s−1] 5 10 25 BIMF [mG] 3.2 1.6 16 BProxima [G] 1200 600 600 BProxima b [G] 0.16−1.28 0.16−1.28 0.16−0.64 i [degrees] [0 - 90] [0 - 90] [0 - 45] ▶Sub-Alfv´enic scenario: ρsw v 2 sw < B2 sw/(8 π) ▶Super-Alfv´enic scenario: ρsw v 2 sw > B2 sw/(8 π) (Bow shock is formed) ▶Coronal mass ejection: Super-Alfv´enic scenario, with both ρsw v 2 sw and B2 sw/(8 π) increased enormously for short time period. HABITABILITY - Magnetopause standoff distance as a proxy for planetary shielding - Life not that harsh in Proxima b! 0 20 40 60 80 Tilt(deg) 1 2 3 4 5 Rmp/RProxima b Sub-Alfvénic Standoff distance 0 20 40 60 80 Tilt(deg) 1 2 3 4 5 6 7 Rmp/RProxima b Super-Alfvénic Standoff distance 0 10 20 30 40 Tilt(deg) 1.5 2.0 2.5 3.0 3.5 Rmp/RProxima b CME Standoff distance 0.64G 0.32G 0.16G 0.2 0.4 0.6 0.8 1.0 1.2 BProxima b(G) 4 5 6 7 8 9 Rmp/RProxima b Sub-Alfvénic Standoff distance 23 deg 0 deg 0.2 0.4 0.6 0.8 1.0 1.2 BProxima b(G) 6 7 8 9 10 11 12 Rmp/RProxima b Super-Alfvénic Standoff distance 23 deg 0 deg 0.2 0.3 0.4 0.5 0.6 BProxima b(G) 1.5 2.0 2.5 3.0 3.5 Rmp/RProxima b CME Standoff distance 45 deg 23 deg 0 deg • Shielding decreases as tilt increases (top). • Shielding increases as intrinsic planetary magnetic field increases (bottom panels). ▶Calm space weather: If magnetic field of Proxima b similar to that of the Earth (Bp = B⊕≈0.32 G) or larger, magnetopause standoff distance is large enough to shield the surface from the stellar wind for essentially any planetary tilt. ▶Coronal mass ejection (CME): Proxima b well shielded if magnetosphere Earth-like (Bp≈B⊕), or tilt smaller than that of Earth (i ≈i⊕≈23.5 deg). RADIO EMISSION - Detection prospects - Radio emission very high under Super-Alfv´en and CME-like conditions. Caveat: Low frequency 0 20 40 60 80 Tilt(deg) 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 P(1019erg/s) Sub-Alfvénic Magnetopause 0 20 40 60 80 Tilt(deg) 0.2 0.4 0.6 0.8 1.0 P(1019erg/s) Super-Alfvénic Magnetopause 0 20 40 60 80 Tilt(deg) 2.4 2.5 2.6 2.7 2.8 P(1019erg/s) Super-Alfvénic Bow Shock 0 10 20 30 40 Tilt(deg) 2 4 6 8 10 12 P(1021erg/s) CME Total Emission 0.64G 0.32G 0.16G 0.2 0. | poster |
3D Climate Modelling of TRAPPIST-1 c with a Venus-like atmosphere: Large-scale circulation and observational prospects D. Quirino1,2, G. Gilli1,3, T. Navarro4,5, M. Turbet6, T. Fauchez7,8, P. Machado1,21.InstituteofAstrophysicsandSpaceSciences(IA),Lisbon,Portugal(dfquirino@fc.ul.pt);2.FacultyofSciences,UniversityofLisbon,Lisbon,Portugal;3.InstituteofAstrophysicsofAndalusia(IAA–CSIC),Granada,Spain(gilli@iaa.es);4.TheMcGillSpaceInstitute,Montréal,QC,Canada;5.SpaceScienceInstitute,Boulder,CO,UnitedStates;6.LaboratoiredeMétéorologieDynamique/IPSL,CNRS,SorbonneUniversité,ÉcoleNormaleSupérieure,PSLResearchUniversity,ÉcolePolytechnique,75005Paris,France;7.NASAGoddardSpaceFlightCenter,Greenbelt,MD,UnitedStates;8.AmericanUniversity,Washington,DC,UnitedStates . IntroductionThe population of close-in Earth-sized exoplanets orbiting late-type M-dwarf stars has increased in the recent years (e.g., [1, 2]), creating an unique opportunity: best targets for terrestrial planets atmospheric studies. Methods Thermal Structure TRAPPIST-1 c atmosphere is warmer than Venus’s at and above the cloud deck region. The substellar and nightside equatorial profiles are similar from the ground to p ~ 0.01-bar. Between ~20-bar and ~ 0.01-bar, the nightside equatorial region [22.5º N/S] is warmer than the remaining nightside hemisphere, suggesting that a day-night heat redistribution mechanism is present in the equatorial region and throughout a significant atmospheric region. Thermal phase curves & transmission spectra Objectives Large-scale circulation Fig. 3. (Above) Time-averaged (10 orbits) temperature profiles for different regions of TRAPPIST-1 c, compared to the Venus International Reference Atmosphere (VIRA) profile. The red (blue) cross depict the approximate level of sulphuric acid condensation (freezing) point on Venus. Fig. 4. (Left). Zonal and time-averaged zonal wind field. The solid thick (thin) black lines represent isotachs with a 50 m/s (25 m/s) interval.Zonal circulation: eastward equatorial superrotationjet peaking 300 m/s in the uppermost levels of the atmosphere with a clear signature at the cloud top (p~37-mbar). Meridional circulation: two large cells, one per hemisphere (north and south), crossing the pole and redistributing heat f rom dayside to nightside. Fig. 5. (Above). Zonal and time-averaged mass streamfunctions: (a) dayside and (b) nightside. The integration exclude the terminators. Positive (negative) values, i.e., in red (blue), correspond to clockwise (anti-clockwise) motion. Fig. 6. (Left). Relation between thermal phase curves, outgoing long-wavelength radiation (OLR) and temperature fields. In the subplot a the red/blue arrows indicate the longitude corresponding to the orbital phase of peak emission, while the two-head arrow indicate each phase curve amplitude. Orbital phase 0 corresponds to the secondary eclipse, while πis the planetary transit. In subplots (b) and (c) the red/blue cross marks the longitude of the maximum peak emission over the equator. All data is time-averaged for ten orbits of TRAPPIST- 1 c.Fig. 7. (Above) Transit transmission spectra of TRAPPIST-1 c for JWST NIRSpecPrism (0.6 –5.3 μm) andMIRI (5 –20 μm) for: Venus-likeclouds(blue) andclear-sky(black), simulatedwiththePlanetarySpectrumGenerator . Different atmospheric levels can be surveyed with different thermal spectral bands: o CO2 absorption bands will sound mesospheric levels (p ~1-mbar) o Continuum bands will sound the cloud top (p ~ 37-mbar) CO2 absorption bands: larger amplitudes and later peak emission Smaller eastward hotspot offsetVenus-like clouds will screen almost all but the strongest CO2absorption bands in the transmission spectra. The 4.8-μm CO2might become detectable, which could indicate the presence of a high-pressure CO2 a tmosphere. We use the Generic-PCM initially developed by the Laboratoire de Météorologie Dynamique (Paris, France) for exoplanet and paleoclimate studies [13 - 15]. The Generic-PCM includes a dynamic | poster |
KDAR Neutrino Measurements with JSNS2 Johnathon Jordan for the JSNS2 Collaboration University of Michigan Poster #482 Proton Beam Linear Accelerator RCS MLF MLF Beam Layout Mercury Target When charged kaons decay at rest, they can produce monoenergetic neu- trinos from the two-body decay: These known-energy kaon de- cay-at-rest (KDAR) neutrinos can be used to make a variety of interesting physics measurements. KDAR Neutrino Proton Neutron KDAR Neutrino Neutrino-induced Nuclear Excitations Neutrino-Nucleon Interactions *Cartoon KDAR Neutrino Basics The MLF Neutrino Source KDAR neutrinos offer a standard candle to benchmark neutrino interac- tion models relevant for future oscilla- tion experiments [1]. Their intermedi- ate energy allows them to probe the transition between neutrino-nucleus and neutrino-nucleon scattering [2]. KDAR neutrinos can also be used for a variety of other measurements [3,4]. The J-PARC Material and Life Science Experimental Facility (MLF) is a spall- ation neutron source in Japan. A high intensity proton beam is accelerated to 3 GeV by the Rapid Cycle Synchrotron (RCS) and delivered to a liquid mercury target in the MLF. In addition to provid- ing a world-class spallation neutron source, the mercury target is also an intense source of decay-at-rest (DAR) neutrinos. The MLF design beam power is 1 MW and the beam power has been steadily increasing (in June beam power has been ~610 kW). The 3 GeV beam energy is high enough for kaons to be produced in the target where they quickly slow down and decay at rest. This fact combined with the high beam intesnity makes the MLF the best place in the world to do physics with KDAR neutrinos. 104 105 106 107 Neutrino Flux (Arb. Units) µ π K −600 −400 −200 0 200 400 600 800 1000 Time (ns) 0 20 Current (A) ×25 Hz Beam Pulses 0 100 200 300 -8 10 -7 10 -6 10 -5 10 -4 10 -3 10 -2 10 -1 10 Energy (MeV) ν/POT/2 MeV The JSNS2 Experiment Neutrino Flux + Timing θ 2 2 sin 4 − 10 3 − 10 2 − 10 1 − 10 1 ] 4 /c 2 [eV 2 m Δ 2 − 10 1 − 10 1 10 2 10 90%C.L 2 JSNS LSND 99%C.L LSND 90%C.L OPERA(2013) 90%C.L 1 MW x 3 years exposure 1 detector (17 tons fiducial) Protons are delivered to the MLF at 25 Hz in two pulses. Neutrinos from kaon decays are produced in time with the beam due to the short kaon lifetime. The low duty factor of the beam re- duces beam-off backgrounds to KDAR neutrino measurements. Most neutrino parents decay at rest in the target and shielding, so the result- ing neutrino flux largely consists of well-understood decay-at-rest compo- nents. Thus, decay-in-flight (DIF) neu- trino backgrounds to KDAR neutrinos are small. The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) [5] is a short baseline neutrino oscillation experiment. JSNS2 is de- signed to search for oscillations with ∆m2 ~ 1 eV2 using the double coincidence signature of IDB (prompt positron, delayed neutron capture). JSNS2 has collected 10 days of initial data this month (expected to contain 200-400 KDAR events) and will continue operation in the fall. JSNS2 utilizes a liquid scintillator (LS) neutrino detector consisting of an inner volume filled with gadolini- um-doped LS and outer buffer and veto regions filled with undoped LS. Scintillation light is collected by 120 10-inch PMTs including 24 PMTs in the veto region used to reject activity origi- nating outside the detector. There is additional shielding under the detec- tor to reduce environmental gamma backgrounds produced in the concrete hatch the detector sits on. KDAR Signatures in JSNS2 References + Acknowledgements Other JSNS2 Posters JSNS2 is most sensitive to KDAR neutri- no charged current interactions. In most events, the expected event sig- nature is a double coincidence be- tween the initial neutrino interacion products and the subsequent muon decay (lifetime ~2.2 μs): In ~20% of interactions, the final state is also expected to con | poster |
Team design for team science Emerging Methods and Tools for Sparking New Global Creative Networks COINs15 Tokyo – Jeff Horon, Consultant, Elsevier Research Intelligence – http://jeffhoron.com Emerging methods and tools are changing the ways participants in global creative networks become aware of each other and proceed to interact. Some web-based resources intended to spark new collaborations in creative networks have been plagued by dependence on fragmented or out-of-date information, having shallow recall (e.g. limited to a list of manually curated keywords), offering poor interconnectivity with other systems, and/or obtaining low end-user adoption. Increased availability of information about creative network participants' activities and outputs (e.g. completed sponsored research projects and published results, aggregated into global databases), coupled with advancement in information processing techniques like Natural Language Processing, enables new web-based technologies for discovering subject matter experts, facilities, and networks of current and potential collaborators. Large-scale data resources and NLP allow modern versions of these tools to avoid the problems of having sparse data and also provide for deep recall across many disciplinary vocabularies. These are "passive" technologies, from the perspective of the network participant, because the agent must undertake an action to use the information resources. Emerging "active" methods and tools utilize the same types of information and technologies, but actively intervene in the formation of the creative network by suggesting connections and arranging virtual or physical interactions. Active approaches can achieve very high end-user adoption rates. Both active and passive methods strive to use data-driven approaches to form better-than-chance awareness among networks of potential collaborators. Recent case studies suggest the existence of repeatable strategies for facilitating data-driven matching and better-than-chance interactions designed to spark new global creative networks. Abstract Active / Interventional Networking Methods Passive Networking Suggested casual interactions at physical events and These emerging methods and tools suggest the existence of repeatable strategies for facilitating data-driven matching and better- than-chance interactions designed to spark new global creative networks. As these methods become further systematized and see wider adoption, they are poised to influence larger numbers of creative networks and their participants. Conclusions scheduled interactions at physical events Identification via mining network structures Outcomes Identification via survey / self-identification Arrange researchers and concepts into a self-organizing bipartite network Eliminate matches that already collaborate The remainder are suggested matches… …. with suggested conceptual connections Participants specify interests, expertise, and needs (often discipline-specific) Score potential matches Issue recommendations | poster |
Polyolefin Family Polymers for Drug Delivery Applications CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has recently expanded its low PDI polymer portfolio and announces its new offering of Polyolefin Family polymers with a wide range of properties that make them well-suited for a variety of drug delivery applications. Low dispersion index polymers are polymeric compounds with low molecular weight dispersion. Typically, the structures of such polymers are designed to reduce their dispersion in solution, thereby improving their stability and controllability. They’re widely used as drug carriers mainly because of their ability to efficiently carry and release drug molecules, thereby improving drug bioavailability and therapeutic efficacy. The design of such drug carriers also helps to overcome some of the limitations of conventional drugs such as biostability, water solubility and drug distribution in the body. The Polyolefin family is a class of polymers derived from simple hydrocarbons with a wide range of promising drug delivery applications. These materials, which include polyethylene and polypropylene, have a number of unique properties suitable for various pharmaceutical applications. For example, Polyolefins' inertness, biocompatibility, and ability to be tailored to specific drug release profiles make them particularly attractive for the design of drug delivery systems. In addition, Polyolefin-based drug delivery systems offer excellent stability, ensuring that drug formulations remain intact over time. The biodegradability and minimal toxicity of Polyolefins also make them attractive for the development of sustained-release formulations. Moreover, the tunable properties of Polyolefins allow modulation of drug release kinetics, resulting in precise control of the therapeutic dose. This family of polymers has proven advantageous in improving the efficacy and safety of drug release and overcoming the challenges associated with conventional formulations. As research continues, the Polyolefin family will continue to attract the attention of scientists and pharmaceutical experts, demonstrating its potential to revolutionize drug delivery strategies and improve patient outcomes. CD Bioparticles recognizes the potential of the Polyolefin family for pharmaceutical applications and has developed innovative drug delivery systems using Polyolefins based on their inherent properties. The company is committed to working with partners on a number of research and development projects aimed at delivering a variety of drugs using Polyolefins and bringing these novel drug delivery systems to market. Furthermore, CD Bioparticles strives to make further groundbreaking contributions to the field of drug delivery and will continue to honor its commitment to innovation. | poster |
Is AD Leo entering a polarity reversal? Long-term monitoring of the large-scale magnetic field with ESPaDOnS, NARVAL and SPIRou Stefano Bellotti1,3, Julien Morin2, Lisa Lehmann1, Pascal Petit1, Gaitee Hussain3 and the SLS consortium 1: IRAP, Toulouse (FR), 2: LUPM, Montpellier (FR), 3: ESA/ESTEC, Noordwijk (NL) stefano.bellotti@irap.omp.eu Acknowledgements: Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. The observations at the CFHT were performed with care and respect from the summit of Maunakea which is a significant cultural and historic site. We gratefully acknowledge the CFHT QSO observers who made this project possible. We acknowledge funding from ANR of France (SPlaSH), with PI Xavier Delfosse. Fig 1. Evolution of Bl. Left: optical (circles) and near-infrared (squares) time series between 2006 and 2020. Right: near-infrared time series phase-folded at the stellar rotation period. FWHM of Stokes I ●FWHM useful activity tracer sensitive to Zeeman effect → high Landé factor (geff) lines can reveal activity signal ●Full vs high-geff mask [12]: all FWHM values are larger in the latter case ●Constant vs sine fit: the variations of the 2020b epoch are better described by sinusoid fit (22% decrease in residual RMS) Longitudinal magnetic field ●Disk-integrated, line-of-sight component of the magnetic field (Bl) ●Stellar north pole is dominated by negative dipole all the time ●Global decrease in field strength over 14 years ●Reduced axisymmetry indicated by varying amplitude in the phase-folded time series Fig 2. Phase-folded FWHM curves using full and high-geff masks for near-infrared epochs: 2019a (top), 2019b2020a (middle), 2020b (bottom) ●Increased FWHM variations imply lower degree of axisymmetry ●FWHM phase variations are reflected by ZDI maps Principal Component Analysis ●Apply PCA to mean-subtracted near-infrared Stokes V (2019-2020) to infer details on non-axisymmetric field [13, see also poster of L. T. Lehmann] Zeeman-Doppler Imaging ●Reconstruction of the large-scale magnetic field topology by means of a maximum-entropy algorithm Stellar magnetic cycles With a long-term monitoring of the large-scale magnetic field, we can search for temporal evolution of the topology and uncover stellar dynamo theories. The Sun is an important benchmark: the magnetic cycle is characterised by a 11-yr variation in sunspot number, size and latitude of emergence, and magnetic polarity reversal [1,2]. Spectropolarimetric observations revealed analogous polarity flips also on other stars [3,4]. At the lower end of the main sequence, M dwarfs represent excellent laboratories to study non-solar dynamo mechanisms underlying the generation and preservation of magnetic fields. Conclusions ●Variations in the coefficients are more sinusoidal and amplified → large-scale field is dipolar and its axisymmetry decreases over time Fig 3. Evolution of PCA coefficients for the first three eigenvectors over the near-infrared epochs: 2019a (top), 2019b2020a (middle) and 2020b (bottom). ●First three eigenvectors have signals → on average field is non-axisymmetric Fig 4. Evolution of ZDI map over near-infrared epochs: 2019a (left), 2019b2020a (middle) and 2020b (right). The magnetic maps are in flat polar view, with the north pole at the center and the equator marked by a solid line ●The geometry is poloidal (magnetic energy fraction >90%) and dipolar (>70%), as in 2006-2016 observations ●Axisymmetry decreases from >85% to 48% in 2020b and tilt angle increases from 15o to 56o accordingly ●Decreasing axisymmetry of the large-scale field confirmed by different techniques ●Global evolution of the large-scale field of AD Leo possibly suggesting a magnetic cycle, in the strong aligned dipole category ●Difference of longitudinal and ZDI field streng | poster |
Wake Forest University School of Medicine is the academic core of Atrium Health. • EPIC used to identify all sterile culture sites which grew Serratia Marscens or Liquifascens in our system • Queried 8/1/2016 - 4/15/2022 Julia Cook, MD; Matthew B Anderson, MD; Erin Barnes, MD, MS, FASAM. Infectious Diseases at Atrium Health Wake Forest Baptist Health A Case Series of Serratia Marcescens Infectious Endocarditis in Persons Who Inject Drugs Demographics Age (years) 29.5 Race N (%) Black 2 (9) White 20 (91) Gender Male 6 (27) Female 16 (82) HCV exposed 19 (86) Background Results • Serratia marcescens is a gram-negative bacillus that is widespread in the environment • Rare cases of endocarditis caused by this organism have been reported • Atrium Health Wake Forest Baptist (AHWFB) in North Carolina has experienced an increasing number of severe infections with Serratia marcescens, particularly in persons who inject drugs Methods Characteristics Bacteremia Duration xxxxx Substances Used N (%) Opioid Injected 16 (73) Stimulant Injected 3 (14) Stimulant Without Route Stated 10 (45) Blood Culture Serratia Only 16 (73) Polymicrobial 6 (27) Prior IE Episode 9 (41) Prosthetic Valve Present 4 (18) 9% 35% 43% 13% Valves Involved Aortic Mitral Tricuspid Pulmonic Complications Emboli N (%) Lung 10 (45) Cerebral 7 (32) Major Arterial 5 (23) Other Epidural abscess 1 (5) Septic Arthritis or Osteomyelitis 4 (18) Endophthalmitis 1 (5) Surgery and Disposition Surgery N(%) Aspiration 2 (9) Valve Repair 16 (73) Valve Replacement 3 (14) Disposition Deceased 4 (18) Left AMA 4 (18) Remained in AHWFB Facility for Duration 16 (73) Other† 2 (9) †One was transferred to another facility and one was discharged for daily infusions administered in an infusion center through peripheral IVs placed each day 284 • 693 reports representing 293 individuals • 9 removed for age less than 18 96 • 188 without evidence of injection drug use 42 • 54 did not meet criteria for at least possible endocarditis by Modified Duke Criteria 22 • Serratia was secondary to line infection • Serratia was not targeted for endocarditis treatment • Serratia was secondary to separate process • Injection drug use timeline not clear Discussion 9% 45% 5% 41% Final Regimen Deceased Beta-Lactam Alone Fluoroquinolone Alone Beta-Lactam + Fluoroquinolone • AHWFB has a large number of Serratia IE cases in PWID, the largest number reported in the US since a 1969-1974 series in the San Francisco Bay Area • Likely sources include contaminated tap water used for drug mixing • Further study to determine if this a regional or national trend is warranted as is study on the ideal treatment regimen | poster |
BIBLIOGRAPHICAL DATA WORKING GROUP For decades bibliographical information has been among the most widely-used resources in the humanities. “Bibliographical Data” Working Group aims to foster cooperation between all the parties involved in bibliographic data life cycle in the humanities, especially between data creators, curators, researchers, developers, and theorists of documentation and bibliography. Data preparation for advanced research Facilitating international data-based cooperation Methodological issues Publishing bibliographies Processing bibliographic metadata Remediation of bibliographical information Development of user-oriented services IF YOU INTERESTED IN THE WG, PLEASE CONTACT US: Tomasz Umerle: tomasz.umerle@ibl.waw.pl Vojtěch Malínek: malinek@ucl.cas.cz @bibliodataWG Bibliographical Data Landscape Analysis Report data production and use analysis challenges and opportunities for public stakeholders crucial stakeholders public and private dimensions of the landscape Goals for 2020: MISSION STATEMENT: bibliodata software bibliodata in research bibliodata and scholarly primitives Bibliographical Data Workflows - Workshop advocating for a joint public stakeholders agenda bibliodata and LOD subject bibliographies Web archiving discovery platforms for bibliodata AREAS OF INTEREST 25th November 14:00 MORE INFORMATION ABOUT THE WORKSHOP AT: https://dariah-ae-2020.sciencesconf.org/309669 | poster |
SWEET-cat: The cat is still sweeter! A catalog of stellar parameters for stars with planets Sérgio G. Sousa et al. Instituto de Astrofísica e Ciências do Espaço & Centro de Astrofísica da Universidade do Porto Abstract: This is a story of two cats that discover that astronomers have presented a sweet cat. What is this sweet cat? Are there cats in other worlds? Is there something more, something else? Top left: The metallicity distributions for two different populations classified according to the higher planetary mass in the system: low-mass planet hosts (LMPH: 99 planet hosts), and high-mass planet hosts (HMPH: 771 planet hosts) with homogeneous parameters from SWEET-Cat. The mass separation value is 30 earth masses. The very well known metallicity correlation is very clear for massive planet hosts, while stars hosting only low massive stars seems to be no different from the general population of stars. Top right: The updated version of SWEET-Cat contains accurate determination of surface gravities (orange points) which are computed using GAIA astrometry and photometry. For details, please see Sousa et al. 2021. Bottom right: Using the updated homogeneous spectroscopic parameters listed in SWEET-Cat we can still find a correlation in the metallicity-period-mass diagram hinting that the mass of planets increase with the period and the metallicity. This trend cannot be fully accounted by observational bias as demonstrated in Sousa et al. 2019. References: Sousa, S.~G., Adibekyan, V., Delgado-Mena, E., et al.; 2021; A&A, 656, A53. doi:10.1051/0004-6361/202141584 Sousa, S.~G., Adibekyan, V., Santos, N.~C., et al.; 2019; MNRAS, 485, 3981. doi:10.1093/mnras/stz664 Sousa, S.~G., Adibekyan, V., Delgado-Mena, E., et al.; 2018, A&A, 620, A58. doi:10.1051/0004-6361/201833350 Andreasen, D.~T., Sousa, S.~G., Tsantaki, M., et al.; 2017, A&A, 600, A69. doi:10.1051/0004-6361/201629967 Sousa, S.~G., Santos, N.~C., Mortier, A., et al.; 2015, A&A, 576, A94. doi:10.1051/0004-6361/201425227 Santos, N.~C., Sousa, S.~G., Mortier, A., et al.; 2013, A&A, 556, A150. doi:10.1051/0004-6361/201321286 Acknowledgments: Sérgio G. Sousa aknowledges the support from FCT through Investigador FCT contract nr. CEECIND/00826/2018 and POPH/FSE (EC). Check our last paper: | poster |
1 Georgia State University, 2 European Space Agency, 3 University of Hawaii Varun Chaturmutha1, Bernhard Fleck2, Stuart Jefferies1,3 Probing the Atmosphere of the Sun-As-A-Star Using Seismic Waves varun@astro.gsu.edu (2a) Layer Separation (2b) Sound Speed (2e) Sunspot Number (1a) Solar Surface-Resolved Data (8 hours) (1b) Sun-as-a-Star Data (1 Year) We use multi-height, line-of-sight Doppler velocity observations of the Sun, as if it were a distant star, to probe the properties the solar atmosphere via travel-time analysis of acoustic-gravity waves. Travel time data from surface-resolved observations of the Sun (1a) have been used historically to estimate atmospheric properties via wave models [1,2,3]. We transfer this technique to sun-as-a-star data (1b) to estimate separation between the observed layers (2a), sound speed (2b), radiative cooling time (2c), and the horizontal wavenumber (2d). (2c) Radiative Cooling Time (2d) Horizontal Wavenumber Website: astro.gsu.edu/~varun Linkedin: vchaturmutha Email: varun@astro.gsu.edu The atmospheric properties estimated using Sun-as-a-star data matches closely with surface-resolved observations of the Sun. The temporal evolution of atmospheric properties (2a, 2b, 2d), is strongly correlated with the solar cycle (2e) of the Sun. This suggests the potential of this technique to probe properties of stellar atmospheres and an alternate method to detect stellar cycle effect. The layer separation between multi-height spectra observations could enable astroseismic tomography of stellar atmospheres, radiative cooling times have implications for atmospheric heating, sound speed offers insights into the temperature structure, and horizontal wavenumber is related to the granular scales. Figure 1: Travel time spectra prepared using (a) surface resolved and (b) Sun-as-a-star, doppler velocities from Na D and Fe I spectral lines. Sun-as-a-star travel time in (b) is prepared by averaging 4 hours of data over 365 days. Figure 2: Temporal evolution of sin-as-a-star atmospheric properties: (a) separation between observing levels, (b) sound speed, (c) radiative cooling time, and (d) horizontal wavenumber. The Sunspot cycle evolution is shown in (e) as a proxy for magnetic activity on the sun. 1) Souffrin, P. 1972, A&A, 17, 458 2) Jefferies, S. M., Fleck, B., Murphy, N., & Berrilli, F. 2019, ApJL, 884, L8 3) Chaturmutha, V., Fleck, B., & Jefferies, S. M. 2024, ApJ, 966, 200 4) Pesnell, W. D., Thompson, B. J., & Chamberlin, P. C., 2012, SoPh, 275, 3 5) Scherrer, P. H., Schou, J., Bush, R. I., et al. 2012, SoPh, 275, 207 6) Forte, R. et al. 2018, in IAU Symp. 335, Space Weather of the Heliosphere: Processes and Forecasts, (Cambridge: Cambridge Univ. Press), 335 INTRODUCTION DISCUSSION DATA ANALYSIS R E S U L T S REFERENCES | poster |
ASSESSMENT OF LOOP-MEDIATED ISOTHERMAL AMPLIFICATION ASSAYS FOR ESCHERICHIA COLI DETECTION Mila Djisalov1, Ljiljana Šašić Zorić1, Ljiljana Janjušević1, Teodora Knežić1, Ivana Gadjanski1 1University of Novi Sad, BioSense Institute, Dr Zorana Đinđića 1, 21000 Novi Sad, Serbia Corresponding author: mila.djisalov@biosense.rs INTRODUCTION: As of lately, loop-mediated isothermal amplification (LAMP) has become a powerful alternative to the polymerase chain reaction (PCR) in the molecular diagnostic world, especially for pathogen detection in clinical and food samples. LAMP is a powerful and new method of nucleic acid amplification, with the ability to detect DNA at a very low level. In comparison to other molecular methods such as PCR and Real-Time PCR, LAMP eliminates the need for sophisticated thermal cyclers. High efficiency of DNA amplification by LAMP significantly shortens the whole amplification process. OBJECTIVES: This study aims to assess the efficacy of two different LAMP kits, WarmStart (Real-Time LAMP) and Colorimetric LAMP in detection of Escherichia coli. We tested and optimized the kits for the detection of E. coli ATCC® 25922 directly from bacterial suspension and indirectly using bacterial genomic DNA (gDNA). LAMP results were then compared with the results of E. coli detection using standard PCR methodology. METHOD / DESIGN: For use in LAMP detection of E. coli directly from the bacterial suspension, we prepared eight bacterial dilutions in concentrations ranging from 1.5x108 - 1.5x101 CFU/mL. All bacterial dilutions were then used for LAMP detection using WarmStart Colorimetric LAMP 2X Master Mix (New England BioLabs) for colorimetric LAMP and WarmStart LAMP Kit (New England BioLabs) for Real-Time LAMP. Real-Time LAMP reactions were done on the Genie® II, an instrument for isothermal nucleic acid amplification (Figure 1). LAMP primers (F3, B3, FIP, BIP, LF, BF) (Figure 2) for the malB gene are taken from the literature. For indirect detection we extracted genomic DNA from E. coli using GeneJET Genomic DNA Purification Kit (Thermo Scientific). Extracted gDNA with the concentration 50 ng/μl was used for preparation of ten-fold dilutions (10-1 - 10-4), and these dilutions were used in both Colorimetric and WarmStart LAMP assays in order to compare limits of detection with and without DNA extraction. Finally, we used E. coli genomic DNA serial dilutions for standard PCR, using F3 and B3 primers for malB gene. RESULTS: The results showed that both LAMP methods (WarmStart and Colorimetric LAMP) enabled the detection of E. coli directly, in suspension (without prior DNA isolation) for bacterial concentration of 1.5 x 108 CFU/mL (Figure 3, Chart 1). Additionally, the results of Colorimetric LAMP using serial dilutions of E. coli gDNA showed detection in all tested concentrations, except the lowest (10-4) (Figures 4-5). On the other hand, the WarmStart LAMP kit enabled E. coli gDNA detection in all tested gDNA dilutions (Chart 2, Figure 6). The conventional PCR methods failed to detect E. coli malB gene product for the lowest DNA concentration (Figure 7.). Additionally, DNA bends on agarose gels are more intensive in the LAMP products compared to those obtained with PCR products. CONCLUSIONS: Presented research showed the incredible power of the LAMP methodology (both, Colorimetric and Real-Time) to detect E. coli even without prior isolation of bacterial gDNA. Also, LAMP enabled E. coli detection even at an extremely low concentration of tested gDNA (50 x 10-4 ng/μl), while with conventional PCR that was not the case. PCR managed to detect bacterial gDNA up to a concentration of 50 x 10-3 ng/μl. Based on these results, LAMP was proved to be more sensitive than PCR, with a large capacity to be used in molecular diagnostics. Also, LAMP is easier to handle since it is more time-efficient and can be performed using portable small devices suitable for on Point-of- Care (POC) research. Figure 1. Genie® II instrument for Real-T | poster |
The Bering Sea Project Archive: a Prototype for Improved Discovery and Access Don Stott, Matthew S. Mayernik, Michael D. Daniels, James A. Moore, Steven F. Williams, and John Allison NCAR Earth Observing Laboratory, Boulder CO, USA, stott@ucar.edu Science-focused use case examples • Identify a geospatial region via data where certain parameters show specific features. • Ex. #1: Find the areas in a defined region where benthic biomass is high for walruses to feed • Ex. #2: Is the line between benthic and pelagic dominated ecosystem shifting? • Find information (data, publications, products) related to a geolocated event. • Ex. #1: Information related to a ship cruise • Ex. #2: Information relevant to under ice CTD data collected in the South Bering Strait vivo.eol.ucar.edu The Earth Observing Laboratory (EOL), as a partner in the NSF funded EarthCollab project, is using linked open data to support scientific collaboration and increase the discoverability and usability of scientific resources. The EOL proof-of-concept Arctic Data Connects web application interlinks datasets from the Bering Sea Project Archive at EOL across platforms and projects. It provides researchers the means to more easily find people, organizations, and resources that are relevant to their work, via semantic and linked data. The Bering Ecosystem Study (BEST) was an NSF sponsored program that provided researchers an opportunity to gain an improved understanding of the linkages between variations in Bering Sea ice cover and the biology of the waters and benthos beneath. A collaborating program, the Bering Sea Integrated Ecosystem Research Program (BSIERP), sponsored by the North Pacific Research Board, collected data in the same region at the same time in an effort to improve understanding and prediction of ecosystem changes related to anthropogenic and natural causes. Over the six-year period of the programs hundreds of multidisciplinary datasets from a variety of instrumentation and measurement platforms within thirty-one categories of research were processed and curated by the NCAR/EOL. The separate BEST and BSIERP data archives were brought together to form the Bering Sea Project Archive in 2010. The EOL organized and continues to maintain the Bering Sea Project Archive as the single source for all data from the combined efforts of the BEST and BSIERP programs. The Bering Sea Project Archive incorporating the BEST-BSIERP Data Archives http://beringsea.eol.ucar.edu Data Linkage with Derived Datasets NSF award numbers are used here to connect datasets and Principal Investigators. As more datasets receive DOIs (Digital Object Identifiers), the DOI will be utilized to link derived products. EarthCollab Data Structures Build ontology extensions for linking: • VIVO-ISF: People, organizations, publications • DCAT: data sets and catalogs • GCIS: Scientific instruments, platforms, projects • Local ontology development to fill gaps Yet to model: • Geospatial and temporal features • Parameters/variables • Use case specific features, e.g. ship tracks EarthCollab is funded by the US National Science Foundation EarthCube program, grants #1440293, 1440213, 1440181, PIs Matthew Mayernik, Mike Daniels, Dean Krafft, and Linda Rowan. Underlying Technology The heterogeneous products of oceanographic field programs such as the Bering Sea Project challenge the ability of researchers to identify which data sets, people, or tools might be relevant to their research, and to understand how certain data, instruments, or methods were used to produce particular results. Arctic Data Connects is employing the open-source semantic web software, VIVO, as the underlying technology to connect the people and resources of virtual research communities. VIVO is being leveraged to address connectivity gaps across distributed networks of researchers and resources and to identify relevant content, independent of location. http://vivoweb.org | poster |
Plataforma para la creación de servicios elásticos big data analytics en la nube Este proyecto ha sido financiado por IVACE y FEDER, a través de la convocatoria de ayudas dirigidas a centros tecnológicos de la CV para proyectos de I+D en cooperación con empresas 2017, 2018 Y 2019 (IMDEEA/2017/139, IMDEEA/2018/94 y IMDEEA/2019/77) Cada vez más empresas están adoptando soluciones de Big Data Analytics. Actualmente existen herramientas gratuitas y de código libre, pero la complejidad de las mismas requiere que sean servicios ofrecidos por centros especializados. Durante 2019, el proyecto Radiatus III continua los trabajos iniciados en 2017 y 2018, avanzando en la investigación, diseño y prototipado de servicios elásticos de Big Data Analytics (BDAaaS) en la nube sobre la plataforma ECloud - Platform as a Service (PaaS), para el tratamiento de datos en tiempo real (Streaming). El proyecto avanzará en soluciones al gran reto que plantea la complejidad de tratar y analizar grandes cantidades de datos recopilados a través de diferentes fuentes y adquiridos en tiempo real, el llamado Big Data Streaming Analytics. A través de estas soluciones las empresas podrán centrarse en el análisis de los datos sin perderse en la complejidad de la infraestructura Big Data necesaria para tal fin. Al finalizar el proyecto, se habrá creado un servicio de Big Data Streaming Analytics en el ecosistema de Radiatus al servicio de las empresas TIC de la Comunitat Valenciana Primera versión del orquestador de servicios con funcionalidades básicas, para el uso en modo "multitenant" del mismo Mejora de la arquitectura y servicios para mejorar su funcionalidad, tolerancia a fallos, rendimiento, seguridad y accesibilidad. Incorporación de nuevas tecnologías Desarrollo de un prototipo de servicio para la plataforma Ecloud , que permita el procesamiento distribuido de modelos de aprendizaje automático | poster |
DNA, the genetic blueprint of life, is targeted by a multitude of damaging species of both internal and external origin. This damage can result in the loss of genomic integrity and increase susceptibility to immunodeficiency, neurological disorders, and cancers. Sophisticated DNA repair mechanisms, such as base excision repair, have evolved to correct the damaged DNA and restore genomic integrity. However, errors within these repair mechanisms can result in mutagenic events. Base excision repair, initiates via the use of a DNA glycosylase. Overactivity of alkyladenine glycosylase (AAG), an example of a DNA glycosylase, can result in accumulation of toxic abasic sites that result in mutagenic events and cause cell death. The design and synthesis of a highly active inhibitor of AAG is required. Herein, the rationale behind the design of azanucleoside mimics of such an inhibitor is described, followed by their synthesis. Additionally, development, optimisation, and application of an AAG inhibitory bioassay will provide some of the key structural activity relationships to allow determination of the feasibility of using these inhibitors as therapeutic agents. | poster |
A major hypoxic blackwater event occurred in 2016 in response to large unregulated flood events in rivers of the southern Murray-Darling Basin. Caused by extensive overbank floods inundate floodplains where large quan- tities of organic matter (e.g. leaf litter/grass) had accumulated. Dissolved organic carbon (DOC) is leached from organic matter and a propor- tion of that DOC is consumed by bacteria which, at the same time also con- sume dissolved oxygen (DO). During the 2016 floods, consumption of DO by bacteria resulted in severe oxygen depletion (hypoxia) in rivers throughout the river system. MMCP Collaboration Factors Contributing to the 2016 hypoxic blackwater event Centre for Freshwater Ecosystems Fact Sheet Management of future events Identify those areas of the floodplain that are likely to make the greatest contribution to organic matter loads (and hence blackwater). Implement more regular inundation of those areas to try and reduce organ- ic matter loads on a more regular basis. Optimize strategies to mitigate impacts on biotic communities (e.g. fish, crayfish). Providing environmental water at locations that provide refuge. Timing of environmental water, to provide refuges for biota at appropriate locations in the Murray-Darling Basin. Contact Centre for Freshwater Ecosystems La Trobe University P: + 61 2 6024 9650 E: cfe@latrobe.edu.au W: latrobe.edu.au/freshwater-ecosystems Further information MMCP Collaboration (MMCP) is a project supported by the Joint State Governments and the Murray-Darling Basin Authority to generate and adopt freshwater ecological knowledge through collaboration, to maintain research capability and contribute supporting science to underpin the Basin-Wide Watering Strategy. Full report: doi.org/10.26181/5d199d3ce698a This synthesis paper is a response to a question poised by the Murray-Darling Basin Officials Committee (BOC) in 2017, in relation to a hypoxic blackwater event that occurred in 2016. The objectives of this theme within the MMCP is to help the BOC address specific questions as they arise. These question will have relevance to the on-going management of Basin Assets. Version 2, July 2019 This project is supported through the Murray-Darling Basin Joint Governments Project team Gavin Rees - CSIRO Land & Water, Albury NSW Causes of blackwater | poster |
ေလ့လာမ&'ပီးဆံ-းသွား'ပီးေနာက် ဘာြဖစ်မလဲ? (လ"ငယ်များအတွက်လမ်း./န်မ1တစ်ခ4) သင့်ရဲ့ပ(းေပါင်းပါဝင်မ.သည်စစ်ေဆးေမးြမန်းသ(ေတွအ ေနအားြဖင့်သင့်ဆီမ:သတင်းအချက်အလက်ေတွကိ@ ြပည့်ြပည့်စံ@စံ@ရB:ိသွားသည့်အချိန်မ:ာCပီးဆံ@းသွားမည် ြဖစ်သည်။ ေလ့လာမ.မ:ာတစ်စိတ်တစ်ပိ@င်းပါဝင်ေပးြခင်းအားြဖင့် ေကျးဇ(းတင်ပါသည်။သင်၏ပ(းေပါင်းပါဝင်မ.သည် အြခားေသာသ(များအတွက်က(ညီရာေရာက်ပါသည်။ MRCTCENTER.ORG/FOR-KIDS ေလ့လာမ&တွင်က,န်ေတာ်/က,န်ေတာ်မတိ/ ့၏ပါဝင် မ&4ပီးဆံ/းသွားသည့်ေနာက်ဘာေတွဆက်ြဖစ်မ?ာလဲ ? သင့်ကိ'မေမ့ပါဘ-း!သင်/0င့်ေလ့လာမ3လ'ပ်ငန်းစ6 တွင်ပါဝင်သည့်ဝန်ထမ်းများသည်ေနာက်ဆက်တွဲ ထွက်ေပ?ေလာမည့်ေမးခွန်းA0ိေသာ်အချင်းချင်း ဆက်သွယ်/ိ'င်ပါေသးသည်။ပံ'မ0န်ေဆးက'သမ3အ တွက်သင်ကိ'ယ်တိ'င်သင့်ဆရာဝန်/0င့်ေတွGရပါလိမ့် မည်။ ေလ့လာမ3ကအြခားေသာသ'ေတသနတွင်ပါဝင်သ- များအတွက်ဆက်လက်လ'ပ်ေဆာင်/ိ'င်ပါေသး သည်။စံ'စမ်းစစ်ေဆးသ-ေတွကသ-တိ' ့လိ'အပ်ေသာ အချက်အလက်အားလံ'းကိ'စ'ေဆာင်းသွားIပီးေသာ် ြငားလည်းသတင်းအချက်အလက်ေတွကိ'စ'စည်း Iပီးမည်သည့်အေKကာင်းအရင်းဆိ'လိ'ချက်အဓိ ပMာယ်ကိ'အေြဖA0ာမIပီးမချင်းေလ့လာမ3ကမIပီးဆံ'း ေသးပါ။ | poster |
United States Environmental Protection Agency Office of Research and Development -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 2 0 0 h N O G - R O C K In h . - Y 2 7 6 3 2 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - N o tc h In h . - D A P T % C o n C a s p a s e 3 /7 -G lo % C o n C e llT ite r-G lo -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - R O C K In h . - Y 2 7 6 3 2 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - E R K 1 /2 In h . - S C H 7 7 2 9 8 4 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - P K C In h . - B IS -1 BMPR Notch EGFR Wnt PPAR-y COX-2 mTORC PDGFR PKC RHO EP1-4 CREB AKT ETC I EGFR NO-cGMP ROCK Protein HDAC PARP1 ERK/MAPK p38/MAPK hNP1 Apoptosis Active Selective hNP1 Proliferation Active/Cytotoxic h. Neurite Outgrowth Inactive r. Neurite Outgrowth Awaiting Data Cortical Synap. To be tested Network Formation 7 3 4 5 6 8 9 1 2 -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 2 0 0 2 5 0 1 5 1 1 6 M K -2 2 0 6 m T O R C In h . -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - C O X -2 In h . - C e le c o x ib -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - E R K 1 /2 In h . - S C H 7 7 2 9 8 4 P331 %control %control %control %control %control %control %control %control -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - A K T A c t. - S C 7 9 • The DNT battery captures some important and highly conserved signaling pathways associated with various processes involved in neurodevelopment. • Specifically, we demonstrated that: • Wnt, mTORC, PKC, and PDGFR pathway modulators have selective effects on neurite outgrowth. • ERK1/2, AKT, and COX-2 pathway modulators demonstrated non-selective effects on neurite outgrowth. • To date, ROCK, NO-cGMP, and COX-2 do not seem to play a significant role in our assays. Future Directions: • Ten chemicals remain to be tested in the battery. • After all chemicals have been tested, a concentration-response analysis will be performed using the ToxCast pipeline. • If we find that developmentally relevant biology is not being adequately recapitulated in the battery, we may explore incorporating other assays that include these pathways. Preliminary ToxCast Analysis Discussion References • These results work in conjunction with the full OECD DNT battery developed in collaboration with global partners. • Our work expands upon previous in vitro DNT pathway characterizations especially when it comes to neurite outgrowth¹, demonstrating that our battery is sensitive to Wnt, PKC, PDGFR, and mTORC disruption. • A more robust characterization of the biology captured by our assays will aid in the interpretation of results gathered using the DNT battery. * The views expressed in this poster are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. • The current NOG data (15 chemicals) has been analyzed using ToxCast R package tcplfit2 (v0.1.6). The computed AC₅₀ for each chemical and endpoint are given in the figure below. • The color scale indicates selectivity, which is determined as the ratio between the cytotoxic AC₅₀ and the AC₅₀ for the endpoint of interest. • Eventually, the AC₅₀ for each chemical and endpoint in the DNT battery will be computed, showing which pathways are best covered by the DNT battery and where improvements are needed. rNOG Neuron count Neurite count per neuron Neurite length per neuron Branch points per neuron DAPT-Notch Inh. ODQ-NO-cGMP Inh. Pioglitazone-HCl PPAR-y IWP2-Wnt Inh. Y-27632 ROCK KG-501-CREB Inh. AG1478-EGFR Inh. Celecoxib-COX-2 Inh. SCH772984-ERK1/2 Inh. SC79-AKT Act. MK-2206-mTORC Inh. CP-673451-PDGFR Inh. MHY1485-mTORC Act. BIS-1/BIM-1-PKC Inh. CHIR99021-Wnt Act. Computed 𝑨𝑨𝑨𝑨𝟓𝟓𝟓𝟓 AC₅₀: Concentration (µM) at which 50% maximum activity is observed. Endpoint Selectivity Ratio Selective Non-selective 3 1 Conclusions Selectivity Ratio = 𝐴𝐴𝐴𝐴50𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶 𝐴𝐴𝐴𝐴50𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸 ≥ 3, Selective Effect 1. Masjosthusmann | poster |
Sourajit Dey Department of Agronomy, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal - 741252, India. “I wish to double the income of farmers by 2022 when India will celebrate 75 years of its independence.” PM Narendra Modi while addressing farmers rally at Bareilly (Feb 28, 2016) “Over the last seven years, the Government of India has taken many initiatives for transforming agriculture. From better irrigation to more technology, more credit and markets to proper crop insurance, focus on soil health to eliminate middlemen, the efforts are all encompassing.” PM Narendra Modi addressing at the webinar on PM-Kisan’s 2nd anniversary (Feb 23, 2021) Not only the farm incomes (i.e. output or the income of the sector or the value added or GDP of agriculture sector) but also the income of farmers. REAL INCOME not NOMINAL INCOME Nominal income can be defined as the income expressed in monetary terms and measured in current currency (in India its Rupee). Real income can be stated as the income of individuals or nations after adjusting for inflation.Real income = Nominal income –Inflation Reduction in arable land. Lower crop yields. Low consumption of pesticides leading to increase in pest attack. Fig- 1 Yields of major crops (tons/ha), 2017 Fig 2- Per capita consumption of pesticides (kg/ha), 2016 Lack of short duration HYVs. Higher cost of production. Imbalance in application of chemical fertilizers. Low Farmers’ Income. Lower irrigation efficiency. Low storage and processing facilities. Lack of marketing facilities. Primitive way of farming. A huge marketing margin taken by middlemen. Fig-3 Percentage of Farm households below poverty line Boost Crop productivity through better technology & increased use of quality seed, fertilizer and irrigation and crop-protection chemicals Incentive structure in the form of remunerative prices of some crops and subsidies on farm inputs Public investments in agriculture Building institutions Crudely, increase in area and productivity can be two major options to increase the agricultural output. Quality seeds (Improving seed replacement rate). Focus on irrigation along with adequate resource building (‘Per Drop More Crop’). Soil-test based nutrient management (Distribution of soil health cards). Opting normal sowing (to take the advantage of the weather anomalies). Pulses as a candidate crop (Pulses in a crop rotation can scale the per unit productivity, diminish the cost of production). Adopting the recommended package of practices (region specific). Supplementing soil with micro-nutrients (like Mn, S, Zn and Fe; if deficient). Use of more bio-fertilizers, vermi-compost and FYM in addition to chemical fertilizers. Post-harvest crop losses (Large investments in warehousing and cold chains). Diversification towards high value crops (Introduction, adaptation and acceptance of new varieties as well as new and upcoming production technologies). Crop protection chemicals are used during both pre-sowing & sowing, post sowing stages of farming. Food crops must compete with 30,000 species of weeds, 3,000 species of nematodes and 10,000 species of plant-eating insects. We know that despite the use of modern crop protection products 20-40% of potential food production is still lost every year to pests. To increase crop yields, continuous improvement of agricultural technologies is required to minimize crop losses. INTEGRATED PEST MANAGEMENT (IPM) Prevention:- Prevention can be done through- Location of crops (best suited to climate, soil, topography) Selection of crop variety (choosing beneficial crop varieties) Crop planting and rotation Soil management Water management Monitoring:- Tools like- pheromone traps, diagnostics and forecasting systems can assist in monitoring. Geographic information systems and remote-sensing techniques can also assist in area wide management. Intervention:- Intervention can be done through- Cultural and physical methods Biolo | poster |
Problem statement Awareness raising seminars Organised by each partner (7 EU Member States), bringing together different stakeholders in the field of migration and child protection Objectives • Raising awareness of the challenges in the field of international family law, migration and refugee law • Collecting feedback and best practices Transnational roundtables Organised by Ghent University and one partner (Münster, Versailles and Milan) Objectives • Improving uniformity of procedures applied to migrant children within the EU, including guardianship decisions, child marriage and kafala • Creating and strengthening sustainable networks between migration law, private international law and (international) family law authorities and organisations in different EU Member States Bookon thechild’s best interest in cross-border civil cases International conference 24-25 June 2024, Brussels Buildingnetworks Collecting empirical data Main objectives Connecting International Family Law and Migration Law Enhancing the Child’s Best Interest in Cross-Border Cases More info: https://famimove.unimib.it/# Belgian partner FAMIMOVE: jinske.verhellen@ugent.be leontine.bruynen@ugent.be geertrui.daem@ugent.be ▪Deficits in the protection of children and family relationships in a cross-border context ▪Migration and asylum authorities, civil servants, judges, welfare services have too little knowledge of private international law instruments and their coordination with EU- and national migration law | poster |
Heracleum sosnowskyi Brânca ursului Familia Apiaceae, Clasa Magnoliopsida SPECII CU ASPECT SIMILAR Foto & illustration credit: Kus Veenvliet, J., P. Veenvliet, M. de Groot & L. Kutnar (eds.). 2019. A Field Guide to Invasive Alien Species in European Forests. Nova vas: Institute Symbioisis, so. e.; Ljubljana: The Silva Slovenica Publishing Centre,Slovenian Forestry Institute. https://species.biodiversityireland.ie/profile.php?taxonId=187116 Frunze submerse Heracleum mantegazzianum 1-3 m Plantă bienală sau perenă, cu o înălțime de 100-300 cm. Tulpina este brăzdată cu pete purpurii și cu perișori. Frunzele, pe fața superioară sunt lipsite de perișori, iar pe fața inferioară prezintă perișori fini. Marginile frunzelor au dinți scurți și rotunjiți. Frunzele inferioare sunt împărțite în trei segmente ușor divizate în părți ovale, scurt ascuțite. Florile sunt albe, uneori rozalii, organizate în umbele compuse, ușor convexe de 30-50 cm. Fructele au formă ovală, sunt dens păroase atunci când nu sunt coapte. Fructele mature sunt aripate, cu numeroși spini situați pe mici umflături sferice sau ovoidale Tulpina Fructe Heracleum mantegazzianum se distinge prin dimensiunea sa, fiind printre cele mai mari plante erbacee din Europa. Poate crește până la 4-5 m înălțime. Heracleum persicum are, în general, 1,5-2,5 m înălțime. În special frunzele și semințele au un miros asemănător anasonului. Heracleum persicum Specie de interes pentru UE | poster |
LO Feynman diagrams for the canonical single top production modes; a) s-channel, b) t-channel, c) tW. Single top quark production – Top quarks at the LHC are produced predominantly via QCD with t partner, – Can be produced singly via EW interactions. Why do we study them? – Direct probes of Vtb and therefore sensitive to new physics, – Background to many searches, – Can constrain PDFs, – Provides measurements of top quark properties. tW production Latest cross section measurements of the tW process at CMS Duncan Leggat Fudan University, Shanghai Dilepton channel Lepton plus jets channel LP2021 – January 22 Duncan Leggat (Fudan University) [1] Higher-order corrections for tW production at high-energy hadron colliders, N. Kidonakis and N. Yamanaka, JHEP 05 (2021) 278, arXiv:2102.11300. [2] Observation of associated production of a single top quark and a W boson, CMS Collaboration, arXiv:1401.2942v2. Inclusive cross section Differential cross sections Diagram Removal vs Diagram Subtraction – tW at NLO interferes with tt and makes simulation difficult, – DR (default scheme) removes diagrams from signal definition, – DS (treated as a systematic) subtracts a gauge invariant term. First observation of tW production [2] The associated production of a single top quark with a W boson Major backgrounds ● tt – shares diagrams with tW at NLO (see below), ● Drell-Yan (dilepton channel), ● QCD and W+jets (lepton + jets channel). Event signature ●2 leptons (muon/electron), ●Associated MET, ●1 jet from a b quark. Event signature ●1 lepton (muon or electron), ●Associated MET, ●3 jets, 1 from a b quark. Analysis strategy ●36 fb-1 pp collision data collected in 2016 by CMS at √s = 13 TeV, ●Data-driven estimation used for QCD background, ●BDT to discriminate between tW and tt background, ●Binned likelihood fit on BDT output to extract tW production cross section. Result Measured cross section: 89 ± 4 (stat) ± 12 (syst) pb First observation of tW in the l+jets channel Leading uncertainties: – JES, data-driven background estimations, tt simulation SM cross section (aN3LO): 79.5+1.9 -1.8 (scale) +2.0 -1.4 (PDF) [1] Analysis strategy ●36 fb-1 pp collision data collected in 2016 by CMS at √s = 13 TeV, ●Using most sensitive eμ channel, ●BDT to discriminate between tW and tt background in 1j1t and 2j1t regions, ●Binned likelihood fit on BDT output and subleading jet pt in 2j2b region to extract tW production cross section. Measured cross section: 63.1 ± 1.8 (stat) ± 6.4 (syst) ± 2.1 (lumi) pb Leading uncertainties: – JES/JER, – Object selection and reconstruction efficiencies, – tt simulation JHEP10(2018)117 CMS PAS TOP-19-003 - CDS record 2712818 JHEP11(2021)111 A fiducial region is defined enriched in tW signal to extract differential measurements. Selected events pre- and postfit Single top quark cross sections measured by CMS | poster |
(pronounced nm-archive) is a FAIR and Open,Consensus-Driven Nuclear Magnetic Resonance (NMR) Data Repository and Computational platform. https://nmrxiv.org Journal of Natural Products 2023 – New NMR Data Requirements recommends NMR data deposition in nmrXiv for new compounds reported in J. Nat. Prod. Articles. nmrXiv: A FAIR and Open, Consensus-Driven NMR Data Repository and Computational Platform V. Nainala, Jena/DE, N. Sharma, Jena/DE, N. Rayya, Jena/DE, S. Kuhn, Tartu/Estonia, J. Liermann Mainz/DE, S. Neumann, Halle/DE, O. Koepler, Hannover/DE, C. Steinbeck, Jena/DE Aims and Objectives Software development To develop a voluntarily FAIR, cloud-based infrastructure that uses freely shared source code and deployment methods. Apply industry-grade development practices to ensure platform reliability, safety, and efficacy. Submission, Curation and Analysis Enable the FAIR Sharing of raw NMR data to enhance the quality of chemical research and dissemination. Also, to develop non-prescriptivist curation and analysis standards for data and metadata. Build standards with input and contributions from the community and make them compatible with existing and potential newly developed formats and approaches. Training To engage analytical chemistry researchers and adjacent communities through webinars, workshops, tutorials, and community calls to ensure that nmrXiv meets the researchers’ needs and implements adequate incentive mechanisms for data contributions and curation. Documentation https://docs.nmrxiv.org Data submissions https://nmrxiv.org Submission Process ~ https://nmrxiv.org Data Backups and RDM FAIR & Open Source Documentation nmrXiv aims to enable the FAIR Sharing of raw NMR data to enhance the quality of chemical research and dissemination. Also, to develop non-prescriptivist curation and analysis standards for data and metadata. Build standards with input and contributions from the community and make them compatible with existing and potential newly developed formats and approaches. NMRium is an open-source NMR spectra visualisation and processing tool and a key integral part of nmrXiv. ●Handles 1D & 2D Spectra. ●Smart Peak Picking. ●Supports various file formats such as JCAMP-dx, Bruker and JOEL output and NMRedata. ●Handles molecular structures. ●Open source - https://nmrium.org nmrXiv data is equipped with robust data backup plan to recover the data in case of disaster. helpdesk@nfdi4chem.de info@nmrxiv.org Data versioning and multi-site disaster recovery ensure data availability and facilitate recovery during server failures, accidental deletions, or security breaches. Why nmrXiv? nmrXiv is the first FAIR and Open archive to preserve NMR data in its original instrument format. It promotes Open Data and Open Standards to maximize the long-term sustainability of the resource and the FAIRness of the archived data. Over the past few decades, several repositories have been developed to host literature-derived and experimental NMR data; however, these repositories do not meet the needs of all chemical communities (also natural products & metabolomics) in several ways. This includes a lack of experimental data, limited search capabilities, and more importantly, they are not FAIR compliant. SmartLab Repos 4Chem Ontologies 4Chem Community 4Chem Legal 4Chem Standards 4Chem Editors 4Chem RAW FILES PROCESSED FILES ~ STANDARD FORMATS LONG TERM ARCHIVAL Version 3.0 Version 2.0 Version 1.0 WEB API AI/ML tools CASE SEARCH ENGINES STEP 1: FILE UPLOAD ARCHIVAL / PUBLISHING STEP 2: ASSIGNMENTS & META-DATA STEP 3: VALIDATION nmrXiv follows a documentation-first approach that allows developers & users to discuss proposed features and ensure that the implementations reflect the real use cases. DOCS: https://docs.nmrxiv.org Advanced Spectra Analysis Demo https://dev.nmrxiv.org Code repository https://github.com/NFDI4Che m/nmrxiv Submission steps* STEP 1: FILE UPLOAD STEP 2: ASSIGNMENT & META-DATA STEP 3: VALIDATION Drag and drop your raw files and | poster |
COLOUR, LIPID AND PROTEIN OXIDATION IN BREAST AND THIGH MEAT OF BROILERS RAISED IN FOUR PRODUCTION SYSTEMS IN BELGIUM Zeshan Ali*, Eline Kowalski and Stefaan De Smet Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Sciences and Aquatic Ecology, Ghent University, Belgium *Corresponding author email: Zeshan.Ali@ugent.be I. INTRODUCTION Worldwide, broilers are raised in different production systems from extensive to intensive, covering a range of genetics and management practices. Influence of the production system on the oxidative stability of meat has not been widely studied [1]. Oxidation of myoglobin, lipids and protein are major causes of quality deterioration in meat [2]. Differences in in vivo and postmortem muscle metabolism may affect the endogenous antioxidant defense system and the release of pro-oxidants and reactive oxygen species, resulting in potential differences in resistance against oxidation. The main objective of the present study was to compare oxidation in breast and thigh meat from broilers produced in four divergent production systems in Belgium. II. MATERIALS AND METHODS In this study, 4 broiler production systems with distinctive characteristics (Intensive, Better Chicken Commitment (BCC), Slow growth with outdoor access and Organic) were selected (Table 1). From each production system, 5 farms randomly distributed in the country were chosen, and 15 broilers (mixed sex; 3 broilers per farm) were slaughtered and sampled. On day 2 after slaughter, the meat from the thigh and breast muscles (skinless) was minced and approximately 40 g was placed in petri dishes. These petri dishes were covered with a foil to limit dehydration and exposed to light (1600-2200 lux) for 7 days in the fridge at 2-4 °C. Colour lightness (L*), redness (a*), and yellowness (b*) were measured daily in duplicate with a Hunterlab Miniscan colour meter (D65 light source, 10° standard observer, 45°/0° geometry, 1-inch light surface, white standard) to estimate colour stability. The difference (day1 – day7) in colour lightness (ΔL), redness (Δa), yellowness (Δb) and total colour difference ΔE (ΔE = [(ΔL)2 + (Δa)2 + (Δb)2]1/2) was calculated for this purpose. On day 7, the samples were vacuum packed and frozen at -80°C for analysis of lipid and protein oxidation. Lipid oxidation was assessed in duplicate, spectrophotometrically by the thiobarbituric acid reactive substances (TBARS) method based on Tarladgis et al. [3] and expressed as malondialdehyde (MDA) in µg per g meat. Protein oxidation was measured in duplicate through the formation of protein carbonyls compounds (PCC), according to the method of Oliver et al. [4] with some modifications by Ganhao et al. [5]. PCC were determined spectrophotometrically, following their covalent reaction with 2,4- dinitrophenylhydrazine (2,4-DNPH), and expressed in nmol carbonyls per mg protein. Table 1 Summary of production characteristics This data was summarized from 18 farms sampled so far (Intensive, Slow growth and Organic n=5 each, and BCC n=3) *Outdoor access was temporarily not possible due to avian flu. Intensive BCC Slow growth Organic Breed Ross 308 RedBroM Ja 757 Ruby XL (SASSO) Age at slaughter (days) 39-42 42-45 56 73-76 Live weight at slaughter (kg) 2.6-2.8 2.4-2.6 2.1-2.3 2.3-2.5 Stocking density (kg/m2) 42 30 27-33 21 Outdoor access No No Yes (limited)* Yes* | poster |
Measuring coastal upwelling using IMOS Himawari-8 and Multi-Sensor SST Helen Beggs, Christopher Griffin, Gary Brassington and Pallavi Govekar Bureau of Meteorology, Melbourne, Victoria, Australia Contact: helen.beggs@bom.gov.au www.imos.org.au IMOS is a national collaborative research infrastructure, supported by Australian Government. It is led by University of Tasmania in partnership with the Australian marine and climate science community. 8. Acknowledgements We acknowledge the provision of raw AVHRR data from ground-stations operated by the Bureau of Meteorology, Australian Institute of Marine Science, Western Australian Satellite Technology Applications Consortium, Geosciences Australia and Commonwealth Scientific and Industrial Research Organisation (CSIRO).We also acknowledge the provision of NPP VIIRS SSTskin retrievals from the National Oceanic and Atmospheric Administration (NOAA) and the provision of the Himawari-8 AHI L1b data from the Japanese Meteorological Agency (JMA) and Japanese Space Agency (JAXA). 1. Introduction The Australian Bureau of Meteorology (BoM) have since 24th March 2016 produced operational, real-time, sea surface temperatures (SST) from the Himawari-8 geostationary satellite every 10 minutes at ~2 km spatial resolution (at nadir) on the native satellite ("GEO") projection. For ease of use, and to reduce spatial data gaps due to cloud, these native resolution SST data have been composited to hourly and daily night-only mean SST files, projected onto the rectangular Integrated Marine Observing System (IMOS) grid at 0.02o x 0.02o. The compositing of the Himawari-8 data on the IMOS grid presents opportunities for use alongside operational IMOS "Multi-Sensor" SST products incorporating data from the Visible Infrared Imaging Radiometer Suite (VIIRS) and Advanced Very High-Resolution Radiometer (AVHRR) satellite sensors, to identify coastal upwelling events. The aim of this study is to determine if these new IMOS satellite products can be used to verify the efficacy of the Bureau's operational version 3.1 Ocean Modelling, Analysis and Prediction System (OceanMAPS) 10 km resolution model (BoM, 2017) in resolving and predicting coastal upwelling around the Australian coast. To assist the study, we also compare with an experimental Ensemble Optimal Interpolation (EnOI) 10 km resolution SST analysis ("GSAS") of the same satellite SST data assimilated into OceanMAPS, using the same Sakov (2014) assimilation system. 4. Coastal upwelling case studies • Himawari-8 Level 2 Pre-processed (L2P) SSTskin is produced by training Himawari- 8 brightness temperatures to NOAA's ACSPO Suomi-NPP VIIRS L2P bias corrected SSTsubskin on a single day in 2015, followed by subtracting 0.17oC • Quality level (QL) is derived for each SST value based on proximity to cloud, identified using GEOCAT method (http://cimss.ssec.wisc.edu/csppgeo/geocat.html), and size of estimated error, estimated on "local brightness temperature variability” • Possible quality levels are 0 to 5, with 5 identifying highest quality • 10 minute Himawari-8 L2P SSTs are composited to hourly Level 3 Collated (L3C) SST by selecting best quality, spatially and temporally consistent value • Hourly SSTs are composited to daily, night-time L3C SST by selecting best quality value, closest in time to local sunrise • Hourly or daily L3C data on GEO projection are mapped to IMOS 0.02o x 0.02o grid using sub-pixel area-weighted averaging of any overlapping pixels (Fig 1a-b) • Night-time Himawari-8 L3C QL ≥ 4 SST from 1 Nov 2017 to 30 Apr 2019 over IMOS domain biased -0.4oC with 0.9oC standard deviation compared with collocated drifting and tropical moored buoys (BoM fv01 SST Validation Web Page) • Himawari-8 L3C netCDF files from 1st October 2017 to present available on request 5. Conclusions We compared night-time 2 km composites of Himawari-8 and Multi-Sensor (AVHRR and VIIRS) SST data at ~0.2 m depth with the BoM operational OceanMAPS v3.1 SST analyses and forecast | poster |
DATA ANALYSIS WITH TOPIC MODELS FOR COMMUNICATIONS RESEARCHERS FREDERICK BOEHM (FRED.BOEHM@WISC.EDU), DEPARTMENT OF STATISTICS, UNIVERSITY OF WISCONSIN-MADISON ABSTRACT We introduce topic modeling as a tool when analyzing textual data. We illustrate our methods with analyses of New York Times transcripts and tweets from three days in March 2016. We argue that such analyses will be useful in mass communications and journalism research. These methods are especially useful for identifying topics, or themes, in large collections of texts, when reading each piece individually is impractical. INTRODUCTION Social media users flood us with tweets, status updates, and blog posts. Data analysis with topic models enable re- searchers to identify themes, or topics, in a collection of texts. We present results from separate analyses of 1) New York Times articles from March 19, 20, and 21, 2016 and 2) a collection of tweets (from Twitter) from the same three days. Our manuscript contains computing code to repro- duce our findings. REFERENCES [1] David M Blei. Build, compute, critique, repeat: Data analysis with latent variable models. Annual Review of Statistics and Its Applica- tion, 1:203–232, 2014. METHODS 1. Fit latent Dirichlet allocation (LDA) models, sepa- rately, to 1) our collection of tweets and 2) our collec- tion of print media articles from the New York Times 2. Visualized the topic modeling results with word clouds 3. Assessed resulting topics for coherence RESULTS video music march song tonight live justin check listen album fly show reaction love night pm ft day bieber watch playlist nowplaying fans radio star today added movie official priceless book la playing np soundcloud stage drake dj de years rihanna house tour young talks feat batman coming band list Figure 1: Word cloud for one topic (from a 20-topic model) of tweets from March 19, 20, and 21, 2016. game city win league season man team leicester today goal points fans united play good back football mufc rashford manchester time half top games state st great year goals player lead players chelsea point penalty west basketball years won marchmadness match derby day big iowa demichelis final premier home live Figure 2: Word cloud for one topic (from a 20-topic model) of tweets from March 19, 20, and 21, 2016. music show film theater production movie song songs musical work director played dance ballet company album play movies set performance life role stage york star country broadway story williams band opera character festival love series sound altman works record shows orchestra plays films center season drama bowie concert dancing singer Figure 3: Word cloud for one topic (from a 20-topic model) of New York Times articles from March 19, 20, and 21, 2016. water baalsrud island men ship arctic boat ships cruise islands expedition sea kelen miles ocean small feet river franklin genz inuit crew story found trip hawaii cruises north food wind norwegian di head escape baalsruds huth snow open pacific frozen joel haug local van coast william lake deck cabin canoe Figure 4: Word cloud for one topic (from a 20-topic model) of New York Times articles from March 19, 20, and 21, 2016. DISCUSSION From the word clouds above, and those not shown, we find differences between the topics of discussion on Twitter and the topics in the New York Times. For instance, we find in the tweets an entire topic that deals with sports (with an emphasis on soccer) and another topic that involves music and entertainment. The New York Times analysis yields topics that match many of the newspaper sections. The two topics above might be called "Music" and "Travel & Adventure". | poster |
The BDF format was created based on EDF, but BDF supports 24-bit resolution. In this sense, if there is a need to convert a BDF file to a more widely used format such as the EDF, there may be loss of information. The GDF format allows several other formats to be converted to it without loss [7]. EDF yielded the best compression capability, and the GDF occupies the largest disk space. The XML-based formats (ecgML, HL7, OpenXDF) follow a pattern in which there is a hierarchical structure with attributes addressing the characteristics and configurations of the file, unlike the others, whose information is based on a sequence of data controlled by the positioning of the characters. It would be interesting to have a tool capable of providing information to manufacturers, developers, researchers of these formats, to keep their information and the characteristics updated, helping thus, future researches, problem corrections and better implementations. ACKNOWLEDGEMENTS REFERENCES DISCUSSION AND CONCLUSION 1Aluno pós-graduação, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia - jpfolador@gmail.com INTRODUCTION The primary purpose of biomedical data acquisition is monitoring, diagnosis or research, and its recording depends on these goals [1]. Thus, monitoring of vital signs in a surgery requires immediate analysis and visualization, whereas data collection for research or diagnosis needs to store the data in the first place, dispensing real- time visualization [2]. These biomedical signals can be continuously measured in different ways depending on the underlying physiological phenomenon responsible for its generation. In any approach related to biomedical signal collection it is necessary to verify memory occupancy and the quality of stored information for avoiding data loss [1][2] A large amount of biomedical data is generated by the recording of time varying signals from different parts of the body, for instance, the electroencephalogram (EEG), electrocardiogram (ECG), electromyogram (EMG), electrooculogram (EOG) and inertial activity. In this context, over the years the medical industry and research consortiums have been addressing the issue of establishing the most suitable data format for the storage of biomedical time-series [3]. The search for standardization and its adoption can reduce costs, optimize joint work, and increase the quality of research results [4]. The first objective of this work was to identify the most used types of file formats employed for storage of time-series resulting from biomedical data. The second purpose was to compare distinct file formats by verifying data compression rates and suitability. MATERIALS AND METHODS In order to understand the file formats used in the recording of biomedical signals and their context today, some questions were raised: • What are the file formats used to collect biomedical signals? • What are the features and information available in these formats? • Is there a file format that is widely used and supports different biomedical signals? • Do commonly used files take up a lot of storage space? [1] Bronzino J. D. Medical Devices and Systems: The Biomedical Engineering Handbook, 3rd ed. CRC Press, Hartford, Connecticut, U.S.A (2006). [2] Penzel, T., Acquisition of biomedical signals databases. IEEE Eng Med Biol Mag 20:25–32. (2001). [3] Rubel, P., SCP: ECG V3.0: An enhanced Standard Communication Protocol for computer:assisted Electrocardiography. In: Computing in Cardiology Conference (CinC), 1–4 (2016). [4] Värri, A., Kemp, B., Penzel, T., Schlögl, A. Standards for biomedical signal databases. IEEE Eng Med Biol Mag 20:33–37 (2001). [5] Institute of Science and Technology: Scientific data formats. http://pub.ist.ac.at/~schloegl/matla b/eeg/. last accessed 2018/01/30. [6] Kemp, B., Olivan, J. European data format “plus” (EDF+), an EDF alike standard format for the exchange of physiological data. Clin Neurophysiol 114:1755–1761. (2003). [7] Schlögl, A. GDF | poster |
SPECTROSCOPIC ANALYSIS OF OB STARS IN THE CARINA NEBULA Simone Daflon 1, Wilton Santos 1,2, João Victor Sales Silva 1, and the Gaia-ESO Survey Team 1Observatório Nacional 2UESC Introduction Massive OB stars are luminous and young objects, being easily observed and located close to their place of birth, allowing the mapping of the present-day abundances of the Galaxy. OB stars are generally found in OB associations, one of them is Car OB, a large, very active star-forming region in the Carina- Sagittarius spiral arm. Its stellar population is split into several open clusters associated with the Carina Nebula. In this work, we present a detailed spectroscopic study for a sample of OB stars located in 8 open clusters in the Carina Nebula: Trumpler 14, Trumpler 15, Trumpler 16E/W, Collinder 228, Collinder 232, Bochum 11 and NGC 3293. Data This study is based on high-resolution spectra obtained with the FLAMES/GIRAFFE spectrograph coupled to the UT2 VLT 8 m telescope, in the context of the Gaia-ESO Public Spectroscopic Survey. The GIRAFFE configurations are optimized to detect important features in the spectra of early-type stars such as Hγ line, an important log g-indicator and some important lines for Teff diagnosis, as for example, C iii, O ii, Si iii, and Si iv lines. Projected rotational velocity We obtained the projected rotation velocity V sin i for a sample of 330 OB stars, probable members of 8 open clusters in the Carina Nebula, based on a calibration for the widths of two He i lines, at λ 4388 and 4471Å[2]. The V sin i distribution for the full sample represented by the blue histogram (Fig 1) is consistent with typical V sin i distributions for open clusters while the V sin i distributions for field OB stars tend to peak at lower V sin i. Fig 2 presents the violin distributions for the 5 clusters of our sample with more than 40 studied stars: the average V sin i for individual clusters varies between 126±77 km s−1, for Collinder 228, and 180±84 km s−1, for NGC 3293. Stellar Parameters and Abundances We use a semi-automatic routine based on non-NLTE model atmospheres and synthetic spectra (TLUSTY/SYNPLOT) [1, 3] to perform a self-consistent analysis and determine the atmospheric parameters Teff, log g, V sin i, microturbulence and macroturbulence, as well as abundances of Silicon, Oxygen, Carbon and Nitrogen, for a subsample of 65 sharp-lined stars. The effective temperature has been defined from the ionization balance between Si ii, Si iii, and Si iv (Fig 3), while log g has been derived from the fits of H wings (Fig 4). Results The stars in our sample are mainly on the main sequence, with Teff between 14,000 and 33,000 K and log g between 3.00 and 4.50 (Fig 5). In Fig 6 we present the violin distributions for the abundances of studied species. The average abundances of C, N, and O are consistent with the solar value while being slightly subsolar for Si. Our results suggest that the Carina Nebula is chemically homogeneous to within ∼ 0.10 dex and the average abundances of O and Si are consistent with its radial position in the Galactic disk (Fig 7), as expected by [1]. References [1]G. A. Bragança, S. Daflon, and et al. A&A, 625:A120, 2019. [2]S. Daflon, K. Cunha, F. X. de Araújo, S. Wolff, and N. Przybilla. The Astronomical Journal, 134:1570–1578, 2007. [3]I. Hubeny and T. Lanz. arXiv:1706.01859, 2017. Acknowledgements W.S acknowledges financial support from CAPES and FAPERJ for Ph.D. fellowships. S.D. acknowledges CNPq/MCTI for grant 306859/2022-0. | poster |
Tau Neutrino Appearance with 8 Years of IceCube Neutrino Data Étienne Bourbeau, for the IceCube Collaboration Niels Bohr Institute etienne.bourbeau@icecube.wisc.edu References [1] S. Parke, M. Ross-Lonergan. Phys. Rev. D, 93, 113009 (2016) [arXiv:1508.05095] [2] Aartsen et al (IceCube Collaboration). JINST 12 P03012 (2017) [arXiv: 1612.05093] [3] Aartsen et al (IceCube Collaboration). Phys. Rev. D, 99 032007 (2019) [4] A. Fedynitch. Matrix Cascade Equation. https://github.com/afedynitch/MCEq [5] G.D. Barr et al. Phy. Rev. D, 74, 094009 (2006) [arXiv: astro-ph/0611266] The IceCube and DeepCore Detectors Neutrino Oscillations in IceCube Unitarity • Significance based on likelihood Test Statistic : 𝑈!" 𝑈!# 𝑈!$ 𝑈%" 𝑈%# 𝑈%$ 𝑈&" 𝑈&# 𝑈&$ + + ² ² ² = 1 + + ² ² = 1 Analysis Principle Digital Optical Module (DOM) • 30 cm photomultiplier tube + digitizer encapsulated in a pressure vessel • Designed to detect Cherenkov radiation from particle interactions in the ice • Elementary unit of the detector 0 m 1450 m 2450 m IceCube Neutrino Observatory [2] • Deployed to detect neutrinos of astrophysical origin • Consists of 86 strings of sensors buried underneath the South Pole The DeepCore Sub-Array • 8 strings of high quantum efficiency DOMs • 10 Mton fiducial volume • ~ 500 sensors in closer spacing • Rest of IceCube is used as a veto region Systematics Uncertainties: Analysis treats uncertainties as nuisance parameters in the fit: • Neutrinos and muon spectral index • Atmospheric Neutrino Flux ([4], [5]) • Quasielastic and resonant form factor • Deep Inelastic scattering cross section • Earth Model (neutrino propagation) • Dom Efficiency • Refrozen ice parametrisation • Bulk Ice absorption & scattering Reconstruction of neutrino events • Charge and time of hits from all DOMs are fed into a likelihood-based event reconstruction algorithm • 𝝊𝝁,𝑪𝑪interactions have mostly track- like profiles, while 𝝊𝒆,𝑪𝑪, 𝝊𝝉,𝑪𝑪and all 𝝊𝑵𝑪interactions produce point-like (ie cascade) profiles • Neutrino oscillations constitute the only experimental evidence of non- conformity to the Standard Model (potential evidence for new physics) • It describes transitions between flavor states to mass states Sensitivity Projections Event Selection Production (as 𝝊𝝁‘s) Propagation (as superpositions of 𝝊𝟏‘s, 𝝊𝟐 ) 𝐬and 𝝊𝟑’s) Detection (as 𝝊𝒆‘s, 𝝊𝝁) 𝐬and 𝝊𝝉’s) • PMNS unitarity constraints are weakest for the third generation of neutrinos, an area where IceCube is highly sensitive [3] • Non-unitarity could indicate that the 3x3 PMNS matrix is a subset of a larger N x N mixing matrix • IceCube operates in energy ranges were 𝝂𝝉,𝑪𝑪cross- section is much less kinematically suppressed than in accelerator experiments • We count the number of neutrinos detected per particle ID (ie flavor), energy and zenith bins • We then compare the result to our expectations from standard oscillation • Tau neutrino fraction is fit as a statistical excess of events in non-track events (ie we don’t identify individual tau neutrino events) Cascade-Like Events Mixed Events Track-Like Events Neutrinos from cosmic-ray interactions in the atmosphere are reconstructed with associated energy and direction (proxy for distance travelled). They allow IceCube to cover a wide range of oscillation baselines (~10 to 10000 km, and 5 to 300 GeV) • We perform a multi-dimensional fit of a Monte-Carlo template to our data. The fit includes both physical (𝜟𝒎𝟑𝟐 𝟐, 𝜽𝟐𝟑, tau normalization 𝑵𝝉) and nuisance parameters to handle systematics. • Ratio of a scenario with 𝑵𝝉= 0.5 w.r.t standard oscillation paradigm −2 𝐿𝐿𝐻+,-./01. 𝐿𝐿𝐻2!34 The Sample in Numbers • Consists of eight years of detector data (mid-2011 to mid-2019) • Several cuts applied to eliminate atmospheric muons and self-triggered noise events (our main backgrounds) • Use of new machine-learning classifiers (boosted decision trees) to perform final- level muon rejection + PID classification • Yields a large statistics sample of neutrinos that well suited for 𝝊𝝁disapp | poster |
Opening mathematical Astronomy by Searching for Orbital Constant that Hidden in variable star cylinder on earth ID 89 1, 2.Department of physics, Dambi Dollo University,Dambi Dollo,Ehiopia Abstract The study of astronomy is needed to integrate variable star with mathematics and science education. In this study we examined the cylinder constant hidden in the formula of the volume of any circular cylinder. Volume of the cylinder(V)= r2h.V= .This Study and digging out the mystery part of a cylindrical coordinate system needed to understand the origin and the nature of celestial (Astronomical) coordinate system that allows Oromo Educators to calculate Oromo Calendar and register it on UNESCO. Keywords:cylinder,height,diameter,circumference, volume, variable constant. 2.Introduction In the history of science, physical science in the geometry, optics, mechanics and astronomy compiled and allowed scientists to develop Physics.This work focused to open the variable star physics experiment in the geometry. Variable stars talk to human kind through their variability. As explained in Serway (2004), Archimedes was the first to compute accurately the ratio of a circle’s circumference to its diameter. 3. Research Question: Can we find a hidden "cylindrical constant" related to variable cylindrical materials 4.Methods: Measurements were taken using local and cultural materials like variable rings, Rope, Qubeelaa Ce'umsaa Figure1.Variablering&Qubeelaa Ce'umsaa 5.Result and Discussion During the variable constant training for every one we have measured the following data is using variable ring. Table 1 No C D 1 51 16.2 The average value of π = = = 3.148 % error = x100%= 0.164% Table 2 .The variable data of the experiment Qubeelaa Ce’umsaa No C D π 1 125.9 40 3.1475 2 126.1 40.1 3.14463804 3 126 40. 3.15 4 126.1 40.1 3.14463804 5 126 40 3.15 Πaverage= =3.147355376 %of error = = 0.1432697% If the percentage error is very small (in variable ring) 0.164% our achievement is 99.836% true. The percentage error of Qubeelaa Ce’umsaa 0.1433% our achievement is 99.867% true. The materials which we use called variable ring and Qubeelaa Ce’umsaa the percentage error is very small which means our experimental error is nearly to the constant or π. π is one of the cylinder constant on the cylindrical objects on the earth. The ratio of volume of cylinder to the product of its circumference, Diameter and height which yield us constant . show the = V = r 2 h ,Since r= ,V= 2 H .Divide both sides for CDH, = Therefore 0.25 is the numerical value of cylinder constant or cylinder geometric pattern. 6.Conclusion We discovered that the origin of π is not solely confined to circular objects, but also extends to ellipses.. The result suggest that the ratio of the volume of a cylinder to the product of its circumference, Diameter, and height is a hidden mathematical constant whose value equal to 0.25.These findings, presented at IAUGA2024, shed light on previously overlooked aspects of physics and geometry. Our work at Dambi Dollo University aims to innovate the study of variable star physics within the context of ancient geometry,contributing the advancement of modern astronomy and sharing our discoveries with the IAU community. 7 .References 1.A text Book of Analytical Geometry of Three Dimensions, by P.K. Jain and Khaleel Ahmed, Published by Wiley Eastern Ltd., 1999.Khaleel Ahmed, Published by Wiley Eastern Ltd., 1999 .2.A text book of Mathematics for BA/B.ScVol 1, by VKrishna Murthy & Others, Published by S. Chand & Company, New Delhi. Delhi.3Archimedes' Secret, transcript ofhe BBC television program Horizon broadcast 14 March 2002; | poster |
Barium daughter tagging using single molecule fluorescence imaging Austin D McDonald, Fernanda Psihas For the NEXT Collaboration Currently, the only known method to determine the Majorana nature of the neutrino is a direct observation of neutrinoless double beta decay. The NEXT experiment employs a series of high-pressure xenon gas TCPs with energy resolution of ~0.7% FWHM at the Q value. The gas phase allows for accurate track reconstruc- tion. Sensitivity to the topology allows for discrimination between back- ground and signal. The theoretical spectrum for the two neutri- no and no neutrino spectrums. 2D diagram of the NEXT detector. Example of NEXT-new data events. The difference between signal and background are the large depositions at the end of electron tracks (two for signal). N N P P e – e – N N P P e – e – ν– ν– Ton-scale neutrinoless double beta decay (0νββ) experiments expect only a few events per year. Radioactive backgrounds in the form of alpha, beta, and gamma decays can mimic the double electron signal. Barium is not produced by any of the backgrounds to ββ decay. Edan Bainglass, Frank Foss, Ben Jones, David Nygren, Pawan Thapa Exploiting a bio-chemistry technique to enhance sensitivity to ββ decay !"#$%&'&"() !"#$%&'()*+,-)- *%+(#,-.$/'&"() ./01 ./01 We employ fluorescent dyes to do Single Molecule Fluorescent Imaging (SMFI). The dye molecule con- sists of a fluorophore, which naturally de-excites via fluoresence, and a receptor, which quenches the fluorescence. The dye molecules are non-fluorescent in the ab- sence of ions. When bound to an ion, the energy levels for fluorescent de-excitation become avail- able. The receptor may be ion specific and can be coupled to different dyes. Development of a dye for use in high pressure xenon gas is currently underway, in collabora- tion with the department of chemistry at UTA. This custom dye is based on PSMA, a molecule know to have high sensitivity to Ba++, and a good candidate for use in xenon gas. Our SMFI implementation may also allow for super-resolution reconstruction, since it local- izes molecule positions to within a few nm. FLUOROPHORE RECEPTOR O O O Cl O Cl HO CH3 N N CO2H CO2H CO2H CO2H FLUOROPHORE RECEPTOR O O O Cl CH3 O O O N N O O O O O O Cl HO Baa++ Total Internal Reflection Fluorescence (TIRF) utilizes evanescent wave excitation to excite the molecules that are a few wavelengths away from the surface. Left: Dye molecule used in our first demonstration of single molecule barium sensitivity. Top: Un-chelated molecule (not fluorescent). Bottom: Molecule chelated to Ba++ ion (fluorescent). Right: Single molecule imaging setup at UTA. The 498 nm excitation light is delivered by a colimated laser, focused on the objective’s backfocal plane. The fluores- cence emmision is collected by the CCD. The objective is used to convert the focused laser light into parallel rays at the critical angle. Single barium di-cation sensitivity has been achieved utilizing the method of Single Molecule Fluorescent Imaging (SMFI) described above. Solutions are made with a specific pH, and diluted to small ion concentration. Trace ions are then removed with a chelation agent. The molecules are immoblized for imaging by trap- ping them in a matrix. Typical TIRF image, showing single molecules located at various depths in the sample. Pixel sixe is 160 nm. The dye’s fluorescence is diffraction limited, this allows for super-resolution reconstruction which localizes the molecule to ~2nm . TIRF was used to image near the surface and minimize fluorescence from deep in the sample by means of evanescent wave excitation. Single barium ion fluorescent tra- jectory, demonstrating the abrupt single step photobleaching. The analysis of barium rich vs no barium samples showed a signal over back- ground at the 12.9 sigma level. Single molecules are identified by the characteristic photobleaching process, where the molecule transitions to a non-fluorescent state in one step. First demonstration of single Ba++ i | poster |
Services OPERAS versteht sich als verteilte europäische Forschungs infrastruktur, die die offene Wissenschaftskommunikation in den Geistes- und Sozialwissenschaften unterstützt. OPERAS-GER ist ein Projekt zur Vernetzung von OPERAS in der deutschen Wissenschaftslandschaft. Kontakt https://operas-ger.hypotheses.org/ www.operas-eu.org @OPERAS_GER Zertifizierungs- service Entwickelt im Projekt: Metrics-/Altmetrics Service Entwickelt im Projekt: Discovery Service (GOTRIPLE) Entwickelt im Projekt: Research for Society Service Entwickelt im Projekt: Weitere Services sind in Planung Publishing Service Portal Entwickelt im Projekt: Über 50 Organisationen aus mehr als 15 Ländern National Nodes - als Kontakt- und Verknüpfungsstelle außerhalb OPERAS - zur Verknüpfung nationaler Infrastruktur mit der europäischen Ebene zuständig für - die Einbindung neuer Mitglieder in die OPERAS Community - den Kontakt zu Forschenden und Akteuren im Bereich Open Access - sowie die Vernetzung mit (potentiellen) Geldgebern Ziele 1. Bekanntheit in der deutschen Wissenschaftslandschaft steigern 2. Zielgerichtet Infrastruktur- und Forschungseinrichtungen, Institutionen, Bibliotheken etc. kontaktieren und einbinden 3. Services präsentieren und Workshops organisieren, um die Bedarfe der deutschen Forschungslandschaft zu sammeln & zu verstehen Poster und Präsentation: Larissa Saar (Max Weber Stiftung/ OPERAS-GER) | poster |
Hochschule für Gesundheit · University of Applied Sciences · Gesundheitscampus 8 · 44801 Bochum alina.napetschnig@hs-gesundheit.de Hintergrund und Ziele Methodik Ergebnisse und Diskussion Die Entwicklung des Gütekriterienkernsets für senior*innengerechte VR-Anwendungen beruht auf einem mehrschrittigen, multimetho- dischen Studiendesign. Die Definitionen und Inhalte der jeweiligen Anforderungen der Kriterien werden in einem iterativen Prozess entwickelt (vgl. Abb. 1). Der Vorgang orientiert sich an dem „Plan, Do, Check, Act“-Kreis (PDCA) und beschreibt vier Aufgaben, die sich zyklisch im Sinne der laufenden Verbesserung wiederholen3. In den einzelnen Teilschritten werden qualitative Forschungsmethoden, wie die Framework Analyse, Gruppendiskussionen sowie Aspekte der Grounded Theory angewendet. Die aufgestellten Kriterien des vorläufigen Gütekriterienkernsets werden anhand einer VR-Trainingsanwendung zur Straßenüber- querung mit Senior*innen zielgruppengerecht und partizipativ in einer Interventionsstudie mit anschließender Gruppendiskussion evaluiert. Die abschließenden Ergebnisse stellen das evaluierte standardisierte Gütekriterienkernset dar. Literatur 1) Baas, J. (2020). Digitale Gesundheit in Europa. Berlin: Medizinisch wissenschaftliche Verlagsgesellschaft. 2) Deiters, W., Höcker, P., Napetschnig, A. & Preissner, L. (2022). Innovationsräume für die partizipative Entwicklung digitaler nutzer*innenzentrierter Anwendungen. In: Department of Community Health (Hrsg.): Community Health - Grundlagen Methoden, Praxis; Weinheim Basel, Beltz Juventa, S. 411 - 423 3) Schönsleben, P. (2016). Integrales Logistikmanagement: Operations und Supply Chain Management innerhalb des Unternehmens und unternehmensübergreifend. Berlin: Springer-Verlag. Die aktuellen Ergebnisse beziehen sich auf den dritten PDCA-Zyklus und bilden das vorläufige Gütekriterienkernset zu den Kategorien: Die Kriterien bilden die Grundlage für die Entwicklung der VR- Trainingsanwendung (vgl. Abb. 2) und können detailliert durch Scannen des QR-Codes eingesehen werden. Die Resultate stellen erste Erfordernisse zu VR-Gestaltungsanforderungen dar. Abbildung 1: Implementierung des PDCA-Kreises in den Produktentstehungsprozess (PEP) zur Entwicklung des Gütekriterienkernsets Quelle: Eigene Darstellung Abbildung 2: Screenshot VR-Trainingsanwendung für Senior*innen zur sicheren Straßenüberquerung Quelle: Eigene Darstellung Virtual Reality (VR) ist nicht nur in der Spieleindustrie vertreten, zunehmend etabliert sich diese innovative Technologie im Gesund- heitssektor1. Ein Leitfaden, der essentielle Gütekriterien für die Entwicklung von VR-Anwendungen für Senior*innen enthält, existiert bisher nicht. Lediglich bestehen allgemeingültige Kriterien für digitale Gesundheitswendungen, die weder zielgruppenspezifisch sind, noch eine Eingrenzung der Technologien beinhalten2. • • • Definition und Evaluierung Anforderungskriterien für den Einsatz von VR in der Gerontologie Problemstellung Bewertung bestehender allgemeingültiger Kriterien für digitale Gesundheitsanwendungen Ergebnis Partizipativ-evaluiertes Gütekriterienkernset mit gültigen Kriterien für senior*innengerechte VR-Anwendungen Take Care 09./10. März 2023 Hauptforschungsfrage: Welche Anforderungen muss eine Gesundheitsanwendung in VR für den Einsatz in der Gerontologie erfüllen? Nutzer*innenorientierte Gestaltung und Bewertung von Virtual Reality-Anwendungen für Senior*innen Alina Napetschnig (M.A.) Allgemeine Anforderungen (I) VR-spezifische Anforderungen (II) 1. Qualitätssicherung med./ gesundheitlicher Inhalte 1. Grafik/ Qualität 2. Datenschutzbestimmungen 2. 3D-Charakter/ Avatar 3. Qualitätsanforderungen 3. Bereitstellen von spielinternen Anweisungen und Aufforderungen 4. Verbraucherschutz 4. Interaktion 5. Interoperabilität 5. Navigation 6. Förderung der Nutzermotivation und Nutzungstreue WEGFEST. – SCAN ME! | poster |
https://www.researchobject.org/ro- crate/community.html info@elixir-belgium.org RO-Crate Toolbox Higher level interfaces for interacting with RO-Crates RO-Crate is a generic packaging format containing datasets and their description using standards for FAIR Linked Data. The format is based on schema.org annotations in JSON-LD, which allows for rich metadata representation of (data-) artifacts as external references when necessary. The format has been implemented in a wide range of services such as WorkflowHub and Galaxy. ro-crate-py The core RO-Crate Python library: ro-crate-py (https://pypi.org/project/rocrate/) provides a high-level interface to create, load and manipulate RO- Crate objects. The core library is in the process of being wrapped in different platforms such as Galaxy tools and other GUI environments. Workflow Run RO-Crate We are co- developing Workflow Run RO-Crate profile to store workflow execution data and metadata, including prospective and retrospective provenance, as well as associated tooling for its generation. from rocrate.model.person import Person alice_id = "https://orcid.org/0000-0000-0000-0000" bob_id = "https://orcid.org/0000-0000-0000-0001" alice = crate.add(Person(crate, alice_id, properties={ "name": "Alice Doe", "affiliation": "University of Flatland" })) bob = crate.add(Person(crate, bob_id, properties={ "name": "Bob Doe", "affiliation": "University of Flatland" })) RO-Crate in Galaxy We have integrated RO-Crate in Galaxy, using ro-crate-py, to allow for the export of RO-Crates. Galaxy can now, for example, generate a Workflow Run RO-Crate from a workflow run and provide it for export by processing the Galaxy workflow definition and - execution details. | poster |
Stoichiometric ratios of 1:1, 1:2, 1:3, 2:1 and 3:1 of Febuxostat and the coformer (probenecid, adipic acid and α-ketoglutaric acid) respectively, were subjected to a liquid assisted grinding (LAG) approach, with the drop wise addition of acetonitrile (25µL) in a mortar and pestle. The ground mixture was then dried in an oven at 80 ºC for 2 hours. Post drying, it was transferred into a dry container and kept in the desiccator. The solid-state characterization of FXT and its eutectic systems was carried out using a differential scanning calorimeter (DSC) and powder X-ray diffraction (PXRD). The DSC results were in turn used to construct the binary phase diagram (BPD) for each system. pH dependent solubility studies were carried out at 25 ºC using the shake flask method over a pH range of 4-10 using different buffered solutions. And the micro-environmental pH studies were performed using the slurry method. Poster No. 21M1200 Febuxostat Eutectics: lost moieties in the quest for Co-crystals Moksh Jagia1, Ruchi Daptardar1, Kinjal R Patel1, Sameer Modi2, Pawan Kumar Singh2, Arvind Kumar Bansal2, Sarsvatkumar Patel1 1Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, NY 2National Institute of Pharmaceutical Education and Research (NIPER), India PURPOSE METHOD RESULTS & DISCUSSION Screening, preparation and characterization of eutectic systems of the drug Febuxostat (FXT), using thermal and analytical techniques, with the initial goal of screening for co- crystals. CONCLUSION REFERENCE DSC indicated towards the formation of eutectic systems by the presence of an invariant low melting endotherm in each case. PXRD confirmed the systems as eutectic with combination peaks of drug and coformer The presence of an acidic micro-environment imparted by the coformers resulted in a substantial loss of eutectic system solubility. Further cocrystallization studies with better coformer selection strategy for the weakly acidic FXT drug needs to be carried out. S. Cherukuvada, A Nangia, “Eutectics as improved pharmaceutical materials: design, properties and characterization,” Chem. Commun. 2014, 50, 906. Badawy, Sherif I. Farag, and Munir A. Hussain. "Microenvironmental pH modulation in solid dosage forms." Journal of pharmaceutical sciences 96.5 (2007): 948-959. A single invariant low melting point (solidus) in all molar compositions is the characteristic of the eutectic phase. While a small variable liquidus point manifests for the near- eutectic or non-eutectic compositions A typical BPD of a eutectic assumes a ‘U” or ‘V’ shape, with the point lacking the liquidus peak representing the pure eutectic phase. While the BPD of a co-crystal assumes a ‘W’ shape. 160 170 180 190 200 210 220 160 170 180 190 200 210 220 0 0.25 0.5 0.75 1 Temperature (°C) Mole Fraction of FXT Solidus Peak Liquidus Peak FXT PROB FXT:PROB Eutectic 130 140 150 160 170 180 190 200 210 220 130 140 150 160 170 180 190 200 210 220 0 0.25 0.5 0.75 1 Temperature (°C) Mole Fraction of FXT Solidus Peak Liquidus Peak FXT ADP FXT:ADP Eutectic 90 110 130 150 170 190 210 90 110 130 150 170 190 210 0 0.25 0.5 0.75 1 Temperature (°C) Mole Fraction of FXT Solidus peak Liquidus peak FXT a-KETO FXT: a-KETO Eutectic 0 2000 4000 6000 8000 10000 12000 14000 4.01 5.63 8.21 10.13 Solubility (µg/mL) pH FXT Drug FXT:Probenecid (1-1) Eutectic FXT:Adipic acid (1-3) Eutectic FXT:a-Ketoglutaric acid (1-3) Eutectic The invariant endotherm for FXT:PROB system appeared around 174ºC, with the single phase melting transition (1-1 ratio) at 175.23 ºC representing the pure eutectic phase. The BPD exhibited a ‘U’ shape characteristic for eutectic formation. The invariant endotherm for FXT:ADP system appeared around 149ºC, with the single phase melting transition (1-3 ratio) at 150.23ºC representing the pure eutectic phase. The BPD exhibited a ‘V’ shape characteristic for eutectic formation. The invariant endotherm for FXT: a-Keto system appear | poster |
Project Sherlock Generating better leads for criminal investigations Technologies Big Data Analytics Volume: Criminal cases can involve many terabytes of data. Velocity: The search for clues is often time-bound by circumstances as well as by law. Variety: Storage devices can contain a great variety of file types, and the layout of individual files is not known beforehand. distributed computing The task of analyzing a storage device breaks down into many smaller tasks, which need to be distributed over the available hardware resources. hardware accelerators Photos and videos can be analyzed much more quickly using dedicated hardware such as GPUs. image analysis Computer vision methods allow for automatically annotating photos and videos with metadata such as the names of people, places, and weapons. data management A dedicated data management solution makes the data searchable, and enables feeding selections of data to visualization tools. Digital storage devices such as harddisks, mobile phones, and USB drives are increasingly common in criminal cases. Extracting viable leads from such a device poses various technological challenges. The Netherlands eScience Center is helping the Netherlands Forensic Institute face these challenges by extending their toolchain with a number of eScience technologies. visualization Interactive visualizations provide insight into the course of events. natural language processing More and better clues are produced more quickly using techniques that extract meaning from textual data. Video Mobile phone Photo Person Camera Camera Location Credit card transaction Mobile phone Person Mobile phone Photo Photo Photo Photo Storage devices Camera Video Video | poster |
IRPPS E-PUBLISHING SERVICE: PERFORMANCE ASSESSMENT AND DEVELOPMENT OF FUTURE SERVICES Roberta Ruggieri, Fabrizio Pecoraro, Marianna Nobile, Rosa Di Cesare National Research Council, Institute for Research on Population and Social Policies, Rome, Italy • Irpps library supports Open Access (OA) promoting digital scholarship as an alternative channel to diffuse niche products in Humanities and Social Sciences • In 2012 Irpps launched “Cnr-Irpps e-Publishing”, a service to manage internal editorial products based on Open Journal System (OJS). The software was customized to support the research needs of its community • Two series are published: Monographs and Working Papers (WPs) • Contents & submission: guideline for the submission and for the management of final editing • Peer review: internal peer review of the WP series, external peer review for Monographs • Copyright & licensing: creative commons, version 3.0. Free access for all contents • Access & preservation: persistent identifier and long-term preservation in Solar - CNR institutional repository Improvements • Quality of abstract • Complete metadata • Accuracy of cited references Background Background • Upgrading to OJS 3.0 with additional functionalities implemented (Altmetrics) • Digitization of previously published works that represent important achievements of IRPPS research results • Development of a data repository linked to IRPPS publications to increase the replicability and reusability of research in Social Sciences • Improvement of the practices and infrastructures to support data sharing and citations Publication workflow Publication workflow Continuity …..and changes to improve quality and quantity of IRPPS publications Continuity …..and changes to improve quality and quantity of IRPPS publications Further enhancements Further enhancements Policies Policies This work is licensed under a Creative Commons Attribution 4.0 International License. Roberta Ruggieri: r.ruggieri@irpps.cnr.it Editorial quality Editorial review and technical editing, that occur before publication in two phases: pre- and post-acceptance Scientific quality Peer review process Improvements • Relevance • Usefulness • Methodological and ethical soundness of research Library catalogue: 118 WPs + 12 Monographs 2012 1981 Page views in 2011: around 5000 2018 Cnr-Irpps e-Publishing service: 100 WPs + 10 Monographs Page views: 2013-2018 around 110000, 16000 users Page views: 2017 around 11000, 3000 users 29 WPs cited 151 citations 70000 downloads 85000 views | poster |
A WLS Reflector, made of copper-tetratex foil, surrounds the LAr instrumenta6on and the HPGe detector strings: Eur.Phys.J.C 82 (2022) 5, 442 CIEMAT Leibniz Inst. for Polymer Research South Dakota Mines Univ. of North Carolina at Chapel Hill Comenius Univ. Los Alamos Natl. Lab. Tech. Univ. Dresden Univ. of Padova and INFN Czech Tech. Univ. Prague and IEAP Max Planck Inst. for Nucl. Phy. Tech. Univ. Munich Univ. of Regina Daresbury Lab. Max Planck Inst. for Physics Tennessee Tech. Univ. Univ. of South Carolina Duke Univ. and TUNL Natl. Res. Center Kurchatov Inst. Univ. of California and LBNL Univ. of South Dakota Gran Sasso Science Inst. Natl. Res. Nucl. Univ. MEPhI Univ. College London Univ. of Tennessee Indiana Univ. Bloomington North Carolina State Univ. Univ. of L'Aquila and INFN Univ. of Texas at Austin Inst. Nucl. Res. Rus. Acad. Sci. Oak Ridge Natl. Lab. Univ. of Cagliari and INFN Univ. of Tuebingen Jagiellonian Univ. Polytech. Univ. of Milan Univ. of California San Diego Univ. of Warwick Joint Inst. for Nucl. Res. Princeton Univ. Univ. of Houston Univ. of Washington and CENPA Joint Res. Centre Geel Queen's Univ. Univ. of Liverpool Univ. of Zurich Lab. Naz. Gran Sasso Roma Tre Univ. and INFN Univ. of Milan and INFN Williams College Lancaster Univ. Simon Fraser Univ. Univ. of Milano Bicocca and INFN Leibniz Inst. for Crystal Growth SNOLAB Univ. of New Mexico 40K 4- 1.15 Gyr 0+ Qβ = 1.5 MeV Stable 89% 40Ca EC 11% 1461 keV 11% 0+ 40Ar Stable zoom 42Ar 0+ 32.9 yr Qβ = 599 keV 2- 42K 12.355 h Qβ = 3.5 MeV 0+ 2+ 0+ 82% 18% 0.34% 42Ca 313 keV 1525 keV Stable 2. LAr Scin+lla+on o 1 μm TetraPhenyl Butadiene (TPB) surface coating by evaporation; o 58 SiPM channels: 58 x 9 Ketek PMT33100T 3x3 mm2 SiPMs. 1. LAr Instrumenta+on Setup The LAr scintillation light emission is superposition of two excimer states (Ar! ∗), which both decay producing 128 nm Vacuum-Ultra-Violet (VUV) light 5. Performance in LEGEND-200 LEGEND-200 experiment for neutrinoless double beta decay search, using HPGe detectors immersed in LAr cryostat To op6mize the LAr instrumenta6on performance the LAr was purified from N2, O2 and H2O. PoS PANIC2021 (2022) 102 q The LAr quality is monitored con6nuously by the LEGEND LAr Monitoring Apparatus (LLAMA). EPJ Web Conf. 253 (2021) 11014 Liquid Argon Instrumenta2on for Background Suppression in LEGEND-200 Experiment 1500 mm Gabriela Araujo1, Laura Baudis1, Nina Burlac2,*, Valerio D’Andrea2, Rosanna Deckert3, Maria Fomina4, Konstan6n Gusev3,4, Patrick Krause3, Alexey Lubashevskiy4, Francesco Paissan2, Laszlo Papp3, Nadya Rumyantseva3,4, Giuseppe Salamanna2, Stefan Schönert3, Mario Schwarz3, Egor Shevchik4, Diego Tagnani2, Daniya Zinatulina4 for the LEGEND collaboraVon 1Universität Zürich, Switzerland 2Rome Tre University and INFN Roma Tre, Italy *currently at Laboratori Nazionali del Gran Sasso (LNGS) of INFN, Italy 3Technische Universität München, Germany 4Joint InsHtute for Nuclear Research, Dubna, Russia q TPB shi]s the VUV light to blue (420 nm); q WLS fibers shi] the blue light into green (490 nm); q The green light is read out by SiPMS (440 nm). 𝜏fast= 30 ns q Event Topology Classifier (ETC) parameter o ra6o of the light emided in the single component to the total light intensity of an event (N = Ns+Nt): ETC = 𝐍𝐬 𝐍 𝜏slow= 8 μs RiseHme 48 ns q The 9 SiPMs are read out in parallel and differenVally by the front-end electronics. q Overall noise level of 250 μV (peak-to-peak) and RMS = 58 μV (mean value). JINST 18 (2023) 09 q Charge and Vme reconstrucVon performed with two independent methods based on rising edge of the trace and differing in the signal filtering: o HyperCurrent algorithm – a Gaussian filter is applied to smooth the electronic noise: 95% charge reconstrucVon efficiency. o DPLMS filter-based algorithm Eur.Phys.J.C 83 (2023) 2 – an op6mum filter is synthe6zed and applied to SiPMs traces: 96% charge reconstrucVon efficiency. LAr veto condi1on: q Test staVsVc-based classifier that categorizes events as true (TC) or random co | poster |
NEED HELP? Designing and Implementing the RITMARE Help Desk to Support Research Data Management Zilioli M.1, Lanucara S1., Oggioni A.1 and Carrara P.1 1National Research Council of Italy, Institute for Electromagnetic Sensing of Environment ISSUES • RITMARE SDI sustainability depends on its data population • RITMARE Data flows differ according to the research groups’ data management practices • Research groups have different data management practices according to disciplinary domains and to data management competences of their members (about informatics, data policy, data sharing) • Different research groups need differential support in order to distribute geospatial data through RITMARE SDI Nodes FRAMEWORK • RITMARE Project involves a Community of research groups working on different marine issues and belonging to different thematic areas • RITMARE Spatial Data Infrastructure (SDI) is built to assure interoperability among geospatial data produced by the different research groups • RITMARE Data flow from the OGC services made available by the distributed nodes of RITMARE SDI, which are either built on purpose during RITMARE or in other projects (External Nodes) • Interoperability is obtained by exploiting OGC standards; data are made accessible through the RITMARE Data Portal, an OGC compliant web client DESIGNING THE RITMARE HELP DESK • Survey the RITMARE Community to identify the different data management practices • Identify different levels of data management competences inside the RITMARE Community thanks to contacts between research groups and RITMARE Data Team • Identify the Helpdesk activities to support research groups according to their data management competences • Identify facility tools and service types to enable research groups to acquire new data management competences in order to distribute geospatial data through RITMARE SDI Nodes IMPLEMENTING THE RITMARE HELP DESK • Identify a webplatform to provide facilities to RITMARE Community • Estabilish the RITMARE Data Team to create contents and provide assistance through a single contact point RESULTS • 20% of new RITMARE SDI Nodes • 32% of new Data Resources distributed through RITMARE Data Portal • 15% of target research groups attended every webinar session CHALLENGES • To define a workflow to engage scientists in data sharing • To manage different use-cases • To manage different raw data formats RITMARE Data Node RITMARE Data Portal RITMARE SDI Node External Data Node RITMARE Research Groups Data Management Practices Data Management Enablement RITMARE SDI Nodes GLOSSARY •45 items •Contents related to collection, format, organization, storage, web distribution, access of geospatial data and their metadata FAQ • 24 items • Contents: RITMARE Data Portal, RITMARE Data Nodes, RITMARE Data Policy TECHNOLOGICAL services EDUCATIONAL facilities Supporting Learning Training LEVEL 0 Not GIS enabled Geospatial data collection and storage via spreadsheets or texts without georeference LEVEL 1 GIS enabled Data storage without distribution LEVEL 2 GIS enabled WebGIS distribution LEVEL 3 GIS enabled Geoservice distribution via interoperable OGC standard services, metadata aware DATA MANAGEMENT COMPETENCE LEVELS GLOSSARY GLOSSARY Data Transfer to RITMARE Data Nodes INSTRUCTIONS/ VIDEO TUTORIAL Installing and assisting new RITMARE Data Nodes Data Connection to RITMARE Data Nodes WEBINAR HELP DESK SUPPORT ACTIVITIES WEBINAR WEBINAR • 2 items • Contents: (I) RITMARE SDI: what is it? Policy and Technological Components; (II) How to create own RITMARE Data Node: GET-IT software suite INSTRUCTIONS / VIDEO TUTORIAL • Contents: How to create own RITMARE Data Node: GET-IT software suite REFERENCES • GET-IT software suite • RITMARE Data Portal (v0.0) ACKNOWLEDGEMENTS The activities described in this poster have been funded by the Italian Flagship Project RITMARE http://www.ritmare.it/ This work is licensed under a Creative Commons attribution 4.0 http://creativecommons.org/licenses/by/4 | poster |
The Keystone Women of British and Irish Botany 1856 to 1932 The network of British and Irish Botanists created from herbari- um specimens digitised on Herbaria@home. Each dot represents a botanist, each line represents a connection between the bota- nists. These links between people are that they either collected together, swapped specimens or determined each others speci- mens. Botanists with only one connection have been filtered out to improve readability and also highlight the most connected botanists. The network has been partitioned into 9 modularity classes to give a rough indication of community structure. Fur- ther details can be found in Groom et al. (2014). Only Woman botanists have been named in order to show how well integrated they were into the network of botanists at the time. The network has been laid out using a Fruchterman Riengold algorithm using Gephi 0.8.2 (Bastian et al., 2009) Bastian M., Heymann S., Jacomy M. (2009). Gephi: an open source software for exploring and manipulating networks. Internation- al AAAI Conference on Weblogs and Social Media. Groom QJ, O’Reilly C & Humphrey T (2014). Herbarium specimens reveal the exchange network of British and Irish botanists, 1856– 1932. New Journal of Botany. 4(2) 95-103. Quentin Groom | poster |
María J. Álvarez-Pérez, Carlos A. Padilla-Jaramillo, B.Sc., Luis M. Díaz-Sánchez, M.Sc., Marianny Y. Combaiza, PhD., Cristian Blanco-Tirado, PhD., and Aldo F. Combariza, PhD. 1. Departamento de Biología, Universidad de Sucre, Sincelejo, 700001, Colombia. 2. Escuela de Química, Universidad Industrial de Santander, Bucaramanga, 680002, Bucaramanga, Colombia. S w e e t e n i n g t h e c h e m i s t r y w o r l d w i t h s p r i n k l e s o f q u a n t u m b i o l o g y Proton and Cation Affinities of Biosignature phytoplankton pigments and MALDI matrices from RI-MP2 quantum calculations Phytoplankton is a bioindicator useful to measure environmental health. Pigment-Biosignature compounds detection for these organisms by MALDI MS, allows its chemotaxonomic identification. Feasible MALDI matrices with thermochemical features (Proton/Cation Affinities -PA/CA- and Ionization Energies -Ei-) guarantees a satisfactory ionization process. So, to establish these properties is a topical issue. We used quantum chemical methods (HF and Pos-HF) to calculate PA/CA energies of MALDI matrices and biosignature pigments. Ⓞ Ⓥ Ⓔ Ⓡ Ⓥ Ⓘ Ⓔ Ⓦ Geometry Optimization Aquatic Ecosystem Vibrational Frequency Electrostatic Maps MALDI MS and Proton/Cation matrices Löwding Charge Analysis δ+ δ- Acknowledgments ●Universidad Nacional de San Agustín (UNSA), Arequipa, Perú for providing access to INKARI cluster facilitis, located at the Observatorio Astronómica Pedro Paulet. ●Thanks to Guatiguara Technology Park and the Central Research Laboratory Facility at Industrial University of Santander for infrastructural support. ●We also acknowledge a graduate fellowship and financial support from SGR- BPIN: 2019000100020 and VIE-UIS project 2815 - 2021. Conclusions Geometry Setup protocol is feasible for our systems, and IR spectra are in agreement with experimental reports. From MEP it would be ideal to perform a Löwding population analysis for determining the protonation sites and associated charge. Next step is to optimize and calculate the SPE to build cation-structures. References ● Denis, Elizabeth H.2022, et al. Proton Affinity Values of Fentanyl and Fentanyl Analogues Pertinent to Ambient Ionization and Detection. Journal of the American Society for Mass ● Padilla Jaramillo, C.A., Díaz Sánchez, L.M. , Combariza Montañez, M.Y. , Blanco Tirado, C. y Combariza Montañez, A.F. 2021. Photon Harvesting Molecules: Ionization Potential from Quantum Chemical Calculations of Phytoplanktonic Pigments for MALDI-MS Analysis. Orinoquia. 25, 1 (jun. 2021), 13–23. DOI:https://doi.org/10.22579/20112629.676. ● Gross, H. J., 2017. Mass Spectrometry.Third Edition. ISBN 978-3-319-54397-0. Springer International Publishing.DOI 10.1007/978-3-319-54398-7 Optimization Method: RI-MP2 Basis set: Def2-TZVP ETol: 1E-08 a.u. MEP maps Method: RI-MP2 Basis set: Def2-SVP IsoValue: 0.004 PS: Protonation Site PS PS PS -0.167 -0.037 -0.052 -0.058 𝛼-CHCA 𝛼-CHCA Method: RI-MP2 Basis set: Def2-TZVP Grapher: XMGRACE Avoiding negative frequencies and comparing the IR spectral The overlapped experimental and calculated IR have good agreement Proton Enthalpy Reaction Zero Point Energy Protonated - Ground Electronic Energy Protonated - Ground Gas Constant Absolute Temperature PS ID: Phys50 | poster |
A photometric study of the ULLYSES/PENELLOPE T Tauri star sample in Ori OB1 and 𝛔Ori: the accretion process at the highest time resolution The ULLYSES/PENELLOPE project on YSO accretion • A legacy spectroscopy survey of accreting pre-main sequence stars, including ~70 T Tauri stars • Synchronized HST COS/STIS as well as VLT UVES/ ESPRESSO/X-Shooter observing campaigns; for a few sources multiepoch observations • ULLYSES (Roman-Duval et al. 2020): accretion and ejection tracers at ultraviolet/optical wavelengths; ODYSSEUS (Espaillat et al. 2022): archive research to model and interpret the HST spectral observations; PENELLOPE (Manara et al. 2021): stellar parame- ters; interstellar extinction, veiling; disk wind and jets; • Unique and contemporaneous UV, optical, and near- infrared legacy dataset of a large YSO sample, covering all evolutionary stages from full disk to transitional disks and Class III disk-less objects The Orion sample • 10 stars in Ori OB1, 3 stars in σ Ori • Sp. type: K6-M3.5, Mass: 0.25-1.1 M⊙ • Distance ~400 pc • CVSO 17, CVSO 36, CVSO 58, CVSO 90, CVSO 104, CVSO 107, CVSO 109, CVSO 146, CVSO 165, CVSO 176, SO 518, SO 583, SO 1153 • ULYSSES/PENELLOPE papers: Manara et al. (2021, survey presentation), Frasca et al. (2021, CVSO104), Espaillat et al. (2022, CVSO109), Froebrich et al. (2022, σ Ori), Pittman et al. (submitted, Ori OB1) • Our goals: (1) extend the project in the time domain; (2) put the spectroscopic results into variability context; (3) identify the underlying physical processes Accretion rates estimated from optical photometry • The X-Shooter UV-optical-infrared spectra were fitted with a model composed of a stellar photospheric template and a slab of gas to simulate the accretion hot spot (Manara et al. 2021) • Adopting stellar and extinction parameters from the X-Shooter model, slab models were fitted to optical broad-band photometry from Konkoly Observatory. We assigned chi2-based probability to each fit, and determined the most likely accretion rate value and its uncertainty at each epoch (left figure) Typical accretion rates: ~10-8 M⊙/yr; variation ⪅3 Variability timescales • The observed timescales of variability are related to the physical processes causing the flux changes • Accretion rate (left) and TESS magnitude (right) differences vs. Δt between any two measurements: • Variability amplitudes steadily increase up to ~2 days, and level off afterward Probably related to rotational timescales Hot accretion spots, funnel flows Does this pattern changes on yearly timescales? References Cody et al., AJ 147, id.82 (2014); De et al., PASP 132, id.025001 (2020); Espaillat et al., AJ 163, id.114 (2022); Frasca et al., A&A 656, id.A138 (2021); Froebrich et al., MNRAS 510, 2883 (2022); Manara et al., A&A 650, id.A196 (2021); Roman-Duval et al., RNAAS 4, id.205 (2020) Acknowledgement This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 716155 (SACCRED). Observations • BVr’i’ images from Konkoly Observatory, Hungary, 2020 Nov 5 – Dec 26 • BVRCICz’ images from OACt, Catania, Italy, 2020 Nov 25 – Dec 16 • BVr’i’ images, AAVSOnet, 2020 Nov 8 – Dec 19 • J-band images, GATTINI survey (De et al. 2020), 2020 Oct 29 – Jan 2 • g-band photometry, ASAS-SN survey • TESS white light (~i-band), 2020 Nov 20 – Dec 16, 10-min cadence TESS (credit: NASA) Characterization of the light curves Left: Example multi-wavelength light curves of CVSO 146. Middle: Distribution of the T Tauri stars in the QM parameter space (based on Cody et al. 2014) • Variability amplitudes: typically ΔV=0.3-0.7 mag, up to 2 mag. Usually decrease with wavelength • Two-parameter description (Cody et al. 2014): degree of periodicity (Q) and flux asymmetry (M), computed from the TESS light curves • QM distribution: three light curves are periodic or quasi- periodic, the remaining ones are close to aperiodic • Most light curv | poster |
Predic'on of an'bio'c resistance from genomic data using machine learning and deep learning approaches Valen&n Laroche, Edithe Selwa, Bogdan I. Iorga Ins$tut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, Gif-sur-YveDe, France bogdan.iorga@cnrs.fr We propose a very efficient knowledge-based approach for input data encoding or dataset enrichment to overcome the intrinsic limitations (small amount of experimental sample, imbalanced datasets) encountered with the use of genomic and biomedical data in machine learning or deep learning predictive models. The KNOTE package for unbalanced dataset enrichment is freely available at the URL: hJps://github.com/IorgaLab/KNOTE Conclusion Introduction This work was supported in part by the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT) [grant number ANR-10-LABX-33], by the JPIAMR transnational project DesInMBL [grant number ANR-14-JAMR-0002] and by the Région Ile-de- France (DIM MALINF). Acknowledgements Results Three different encoding modes of genomic data, each one with its advantages and limita'ons, were used for the prepara'on of input datasets. The performance of several machine learning and deep learning approaches was evaluated using these datasets. The best performance was obtained with Convolu'onal Neural Network approach and knowledge-based dataset encoding. However, a clear limita'on was the unequal distribu'on of classes leading The availability of increasing amounts of genomic and biomedical data makes machine learning and deep learning the methods of choice for the prediction of antibiotic resistance, a worldwide health problem of utmost importance. However, several strong limitations have hampered the development of this field. to imbalanced datasets. The dataset enrichment performed with publicly available soaware (SMOTE, ROSE) provided only liJle improvement in the predic'on accuracy, due to errors introduced during enrichment. In these condi'ons, we have developed a new tool called KNOTE (KNowledge-based Oversampling TEchnique) for the error-free enrichment of imbalanced data from genomic and biomedical studies, to be used in machine learning or deep learning predic'ons. The use of KNOTE- enriched datasets provided up to 95-98% accuracy in the predic'on of an'bio'c resistance. 1. Kos, V.N.; Déraspe, M.; McLaughlin, R.E.; Whiteaker, J.D.; Roy, P.H.; Alm, R.A.; Corbeil, J.; Gardner, H. "The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility" Antimicrob. Agents Chemother. 2015, 59, 427-436. Reference Materials and methods Input datasets were prepared from 390 genomes of Pseudomonas aeruginosa with known minimum inhibitory concentra'on (MIC) values for 4 an'bio'cs [1], using three approaches: knowledge-based (output of ResMiner, a bacterial genome analysis tool developed in our group), n- grams and k-mers. Data availability | poster |
Laura Bader, Marie-Christine Ramel, Toby G. R. Andrews, Kirti Gupta, Jennifer Pearson-Farr, Lucy M. Collinson and Rashmi Priya Summary Nuclear lobularity increases with cardiac forces in ventricle but not in atrium. How the nucleus, one of the stiffest organelles inside a cell, sustains and responds to mechanical forces in vivo remains understudied. The developing zebrafish vertebrate heart is a unique model system to address this fundamental problem as it generates and withstands substantial mechanical forces. Using in toto imaging, 3D morphometrics, genetics, pharmacological perturbations and scRNA-seq, our work reveals that the two heart chambers, ventricle and atrium, have strikingly distinct cardiomyocyte nuclear morphologies, possibly correlating with Lamin A/C expression and microtubule localisation. Manipulation of cardiac forces and knockdown of Lamin A/C affects only ventricle nuclear morphology while microtubule manipulation affects nuclear morphology in both chambers. Of note, overexpressing Lamin A/C in atrium, which naturally lacks Lamin A/C expression leads to nuclear fragmentation. Together, these results indicate that the two chambers have distinct nuclear mechanics, possibly reflecting the underlying difference in the biomechanical environment. 3dpf Ventricle Atrium High Lamin A/C expression Low Lamin A/C expression Microtubules (MT) Cardiac forces Cardiac forces Ventricle Atrium Lamin A/C Lamin A/C MT stability MT stability 1. Nuclear morphology differs between ventricle and atrium a Ventricle Raw image Binary image Label map Nuclei segmentation Morphological filtering, CCL 3dpf myl7:H2B-mScarlet ventricle atrium Ventricle Heart rate + contractility myl7:mScarlet-LAP2b myl7:H2B-mNeongreen myl7:BFP-CAAX 3dpf Atrium Ventricle Atrium Ventricle Atrium Nif (10μM) DMSO IBMX (50μM) Manipulating microtubule stability alters cardiomyocyte nuclear morphology. myl7:EMTB-mNeongreen 3dpf myl7:H2B-mScarlet myl7:BFP-CAAX 3dpf Taxol DMSO Colchicine Ventricle Ventricle Ventricle Atrium Atrium Atrium Ventricle Ventricle Atrium myl7:mScarlet-LAP2b 5dpf Atrium Ventricle outer layer inner layer 4dpf Atrium Ventricle Ventricle 2. Cardiac force manipulation alters ventricle nuclear morphology vmhc amhc vmhc:laminA-mScarlet myl7:laminA-mScarlet myl7 * * * *enucleated cells amhc:laminA-mScarlet myl7:H2B-mNeongreen; myl7:BFP-CAAX 5dpf Overexpression of Lamin A/C is less tolerated in atrium. Microtubules are load-bearing cytoskeletal filaments that regulate mechanics6 and maintain nuclear architecture7. The Francis Crick Institute, 1 Midland Road, London NW1 1AT contact: laura.bader@crick.ac.uk 3. Lamin A/C is differentially expressed in ventricle and atrium The nuclear lamina is composed of lamins, intermediate filaments required to maintain the nuclear integrity1. Lamin A/C (lmna) is thought to regulate nuclear stiffness and mechanosensing2 and to mechanoprotect the genome3. Depletion of Lamin A/C softens nuclei and leads to increased number of mishappen nuclei2,4. In contrast, overexpression of Lamin A/C stiffens nuclei5. - How Lamin A/C regulates nuclear morphology – role of phosphorylation. - How microtubules regulate nuclear morphology – genetic tools. - Functional implications of differential nuclear morphology in ventricle vs. atrium. - Role of LINC (linker of the nucleoskeleton and cytoskeleton) complex. 4. Microtubule organisation regulates nuclear morhology 5. Further work We would like to express our gratidue to the Light Microscopy, Bioinformatics and Biostatistics STPs at the Crick, for their guidance and support at every stage of the project. Special thanks to the BRF for their assistance with fish husbandry. Without their knowledge, hardwork and expertise, this project would not have been possible. Lastly, we would like to thank the organisations who have provided financial support for this work, including The Francis Crick Institute and the British Heart Foundation. Acknowledgements [1] Gruenbaum, Y. and O. Medalia (2 | poster |
Prescott College — For the Liberal Arts, the Environment & Social Justice Critical Review: Is Earth's Outer Core Liquid or a High Density Plasma? Daniel S. Helman Sustainability Education, Prescott College, 220 Grove Ave., Prescott, AZ 86301 danielhelmanteaching@yahoo.com Abstract This work explores composition and melting point data (or lack of data) related to Earth's outer core, and also the possibility of a high-density plasma composition, plus gives a background on Inge Lehmann's seismological observation demonstrating a solid inner core. Implications related to geomagnetic field dynamics are also presented, as are evidence in the rock record for changes to the geomagnetic field over time, including the intersection (if any) of such changes and the origin and development of life on the planet. Keywords geodynamo, plasma, metallic liquid, solid-density plasma, plasma channel, origin of life, geomagnetic field Inner and Outer: How Do We Know? Here are the words of Inge Lehmann, who made this discovery: Evidently, there was a reflection of the waves in the interior of the earth that caused them to emerge at a shorter epicentral distance. It was shown in a simple example how this could happen. I considered a globe in which a hard mantle surrounded a softer core, the radius of which I took to be five ninths of the surrounding sphere. The velocity of the longitudinal waves was 10 km/s in the mantle and 8 km/s in the core. It was then a simple matter to calculate the time curves arising from an earthquake that took place at the surface of the globe. The P curve that resulted from waves confined to the mantle ended at 112° distance from the epicenter. P' consisted of two brances, as observed in the New Zealand earthquake. When the variation of the travel time was considered in relation to the angle of incidence, an estimate of the intensity could be obtained. In this way it was found that the intensity of the waves corresponding to the upper branch of the P' curve would be small. This was in accordance with the fact that it had been difficult to observe the upper branch. No rays emerged at epicentral distances between 112° and 154° (Figure 6). I then placed a smaller core inside the first core and let the velocity in it be larger so that a reflection would occur when the rays through the larger core met it. After a choice of velocities in the inner core was made, a time curve was obtained (Figure 7), part of which appeared in the interval where there had not been any rays before. The existence of a small solid core in the innermost part of the earth was seen to result in waves emerging at distances where it had not been possible to predict their presence. Gutenberg accepted the idea. He and Charles Richter (California Institute of Technology, Pasadena) placed a small core inside the earth and adjusted the radius of this small core until the calculated time curves agreed with the waves observed. Jeffreys was slower to accept the inner core. Jeffreys- Bullen time curves had been completed in 1935. In 1939, a new edition was published in which the inner core had been accepted. ... Inge Lehmann was born in 1888 and received her degree in mathematics in 1920. She later became chief of the Seismological Department of the Geodetic Institute of Denmark, which was established in 1928. As described in this article, she aided in setting up seismic stations in Greenland and Copenhagen. Her studies of the travel times of a special phase led to the discovery of the inner core of the earth in 1936. [1] Is the Outer Core a Liquid or a Plasma? Consider the following quote in light of how a plasma is defined: “The best hard sphere model for the core is a transition metal liquid whose valence electrons form an electron sea bathing and charge-compensating the spherical ionic cores.” [2] The term metallic (or metal) liquid also appears in text related to the core of Jupoter: “Jupiter's magnetic field is caused by convective dynamo motion of electrica | poster |
INTRODUCTION On the frontlines of fighting the COVID-19 pandemic, chest imaging serves as an indispensable tool in the assessment of disease severity, monitoring the disease progression as well as for treatment planning. With only a handful of reports on radiographic patterns of COVID-19 infection across the literature, we aim to describe the radiographic characteristics of COVID-19 pneumonia in Malaysia. Chest radiographs (CXR) of laboratory confirmed COVID-19 patients in Hospital Tawau, Sabah were retrieved and retrospectively analyzed by two radiologists. The radiographic patterns, distribution among subgroups, and evolution of the disease over time were determined. Criteria Findings Frequency (%) Baseline Chest Radiographs Normal 45 (54.9) Abnormal 37 (45.1) Lung Changes Ground glass opacities 29 (35.4) Consolidation 7 (8.5) Interstitial opacities 4 (4.9) Nodular opacities 1 (1.2) Distribution Peripheral 29 (35.4) Central 2 (2.4) Diffuse 5 (6.1) Lung Involvement Right lung 6 (7.3) Left lung 16 (19.5) Bilateral lungs 15 (18.3) Zonal Predominance Upper zone 4 (4.9) Middle zone 3 (3.7) Lower zone 24 (29.3) No zonal predominance 6 (7.3) Focality Focal 17 (20.7) Multifocal 20 (24.4) Other features Pleural effusion 3 (3.7) Pneumothorax 1 (1.2) Pulmonary nodules 1 (1.2) Lymphadenopathy 0 (0) Follow up Radiographs (n=38) Normal baseline CXRs becoming abnormal 0 (0) Resolution 6 (15.8) Improvement 9 (23.7) Progression 3 (7.9) Computed Tomography (n=5) Typical COVID-19 features 3 (60.0) 82 patients included MATERIALS AND METHODS RESULTS 65 (79.3%) 17 (20.7%) Mean age of 37 ± 15 years 25 8 18 16 1 5 9 24 40 9 16 33 6 2 4 45 M ale Female Symptomatic Asymptomatic Child ren Elde rly Comor bid No Comorb id DISTRIBUTION OF RADIOGRAPHS ACCORDING TO SUBGROUPS Normal CXR Abn ormal CXR with CO VID-1 9 pn eumon ia fe atu res CXR shows ground glass opacity at right lower zone. Coronal CT image shows ground glass opacity at right lower zone corresponds to the finding on radiograph. Asymptomatic COVID-19 patient with consolidation at the left upper zone (arrow) in the baseline radiograph with complete resolution of the opacities on day 5 of admission. REFERENCES C-07 NMRR NO:20-698-54570 CORONAVIRUS DISEASE -2019 (COVID-19): A RETROSPECTIVE REVIEW OF CHEST RADIOGRAPHS IN 82 PATIENTS. Mohana Letchumanan1, Adi Afiq Bin Md Anour1, Shubash Shander Ganapathy2, Syaman Harry1, Nik Shah Hizan Binti Nik Lah1, Norlimah Binti Arsad3, Nur Farhana Binti Ahmad Fisol4 1Department of Radiology, Tawau Hospital, 2Institute for Public Health, National Institutes of Health, 3Director of Tawau Hospital,4Clinical Research Center, Tawau Hospital 1. Choi H, Qi X, Yoon SH, Park SJ, Lee KH, Kim JY, et al. Extension of Coronavirus Disease 2019 (COVID-19) on Chest CT and Implications for Chest Radiograph Interpretation. Radiology: Cardiothoracic Imaging 2020; 2(2): e200107. 2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506. 3. Lomoro P, Verde F, Zerboni F, Simonetti I, Borghi C, Fachinetti C, et al. COVID-19 pneumonia manifestations at the admission on chest ultrasound, radiographs, and CT: single-center study and comprehensive radiologic literature review. Eur J Radiol 2020; 7: 100231. CONCLUSION COVID-19 pneumonia presented with a specific radiographic pattern, comprising of ground glass opacities in peripheral and basilar distribution, affecting a single lung field. We observed these lung changes in both symptomatic and asymptomatic group of patients, and was more frequently manifested by patients with symptoms and comorbid, and those over 60 years of age. Chest radiograph is a useful adjunct screening tool, and in combination with clinical and epidemiological assessment may facilitate in early diagnosis of COVID-19 pneumonia. The authors would like to thank the Director General of Health, Malaysia, for the permission to present this poster | poster |
Workflow Tool for Archaeological Experiments and Analytics Workflow Tool for experiments We are developing an easy-to-use visual workflow tool that will allow researchers to record and illustrate meta- and paradata: experimental design, the protocol of sample preparation, procedure or analysis. The tool incorporates different types of experimental setup, ranging from high-tech controlled automated procedures in a lab to full-scale reconstructions in the field or well-documented re-enactment by a broader public (CC). Users will be able to customize the developed prototype, and increasing familiarity with their needs will be used to improve it. Experiments, reconstruction, replication and reproduction A lack of standards and tools for recording and reporting on archaeological experiments and analytics hinders comparison, scientific knowledge exchange and the evaluation of data quality. We are trying to fill this gap by developing a flexible, easy-to-use visual work-flow tool that will allow researchers to record meta- and paradata: experiment design plus protocols of sample preparation procedures and/or analysis. The need for such a tool has long been recognized, but resources have been lacking. The aim is to produce a prototype of a tool that can be continually improved in line with the needs of our community. About the Poster NFDI4Objects Community Meeting 2024, Mainz. Leibniz-Zentrum für Archäologie (LEIZA) Ivan Calandra, Geoff Carver, João Marreiros, Allard Mees, Guido Heinz, Florian Thiery Leibniz-Zentrum für Archäologie Citation Callandra, Carver, et al. (2024). Workflow Tool for Archaeological Experiments and Analytics. Zenodo. DOI: 10.5281/zenodo.13799052. 1) Monrepos 2) https://denkmalstiftung-baden-wuerttemberg.de/wp-content/uploads/2022/10/Denkmalstiftung-Baukunst_Pfahlbau.jpg 3) https://i.pinimg.com/736x/0c/a0/87/0ca087ca4ce96a5038eaf4608a7f4f2e.jpg 4) https://www.crystalking.com/hubfs/ancientrome.jpg 5) TraCEr List and reorder tasks Start menu Generate task flowchart Populate inventory Plan an experiment 1 2 3 4 5 https://tools.leiza.de/workflowtool/ | poster |
z The Impact of Digital Behavior on Poly-substance Use Among American High School Students: An Analysis using YRBS 2017 to 2021 Laggy George MPH Brooks College of Health INTRODUCTION § Poly-Substance Use (PSU): Significant public health concern especially among adolescents. • Age of Onset: 15-19 years critical for substance use initiation (Blanco et al.,2018). • Poly substance use is more prevalent than single substance use (CDC,2023). • Screen Time (ST): Associated with physical, social, and psychosocial health impacts (Connolly et al., 2024 ) • Explore the association between screen time and PSU in American High School students, using a cross-sectional analysis with YRBS 2021 data. • PSU includes concurrent use of 2 or more drugs intentionally or unintentionally (CDC,2023). • Excess screen time defined as more than 2h/day apart from course work ((AACAP, 2024) OBJECTIVE • Data Source: YRBS 2017-2021, (N=45,132). • Dependent: PSU (concurrent use of substances). • Independent: Screen time, Socio-demographic (gender, age, race/ethnicity, grade), Lifestyle factors (mental health, physical activity, sleep, smoking, alcohol use, opioid misuse). • Statistical Analysis: Chi-square and Multiple logistic regression Using SAS 9.4 English. RESULTS • Baseline characteristics: • Final sample size n=7,251 • 48% females, 52% males. • Majority aged 16-17 years (24%). • Non-Hispanic Whites 53%, Hispanics 25%. • PSU: 21%, and Screen Time >2 h: 91% • ST and PSU Association: • Higher odds of PSU with >2 h per day of ST (AOR = 1.6, 95% CI = 1.03-2.54) Increased odds of PSU also with: • Dose response with age, >18yrs, (AOR = 27.7, 95% CI = 5.84-131.9) • Opioid misuse and Alcohol 3 times higher odds, while smoking 10 times higher odds. • Gender and Race differences: Males, non- Hispanic Blacks had higher odds (Table 1) • Physical activity 5 days a week for 60 mins/day (AOR = 0.8, 95% CI = 0.68-0.99) • Trends (2017, 2019, 2021): • PSU higher odds 2019 (AOR = 1.3, 95% CI 1.05-1.56, p=0.015) • Excess Screen Time: Significant predictor of PSU; higher likelihood of PSU. • Mental Health: Poor mental health linked to higher likelihood of PSU. • Smoking, alcohol, opioid misuse increased the likelihood of PSU. • Physical Activity: Protective effect against PSU. • Prevention Strategies: Focus on reducing screen time, promoting physical activity, and integrating mental health services. METHOD Table 1 Multiple Logistic Regression Analysis Note: n = unweighted sample size. % = weighted percentage. Significant at p<0.05 • Target lifestyle modifications, including physical activity in highschoolers to reduce screen time. • Health education for parents and adolescents regarding prescription misuse, and substance misuse. • Emphasis on High-risk subgroups. 10% 68% 11% 55% 17% 51% 15% 21% 90% 32% 89% 45% 83% 94% 85% 79% NONE CURRENT ALCOHOL NONE CURRENT OPIOID MISUSE NONE PRESENT SCREEN TIME <=2 H/D >2H Prevalence of Polysubstance Use among High School Students in the United States from 2017-2021 Poly Substance Use (No) Poly Substance Use (Yes) • Chi-square analysis • All values significant at p <0.05 Smoking Variable Odds ratio 95% CI Gender Female reference Male 1.3 1.04-1.63 Age (years) >12-13 reference 14-15 21.7 4.92-95.76 16-17 24.5 5.40-111.24 >18 27.7 5.84- 131.91 Race NH White reference NH Black 1.8 1.24- 2.47 Physical Activity >= 1h/day <5 days a week reference >=5days 0.8 0.68-0.99 Mental Health Good reference Not good 1.9 1.47-2.37 Current Smoking <=30 days None reference Current 9.7 7.78- 12.09 Current Alcoholism <=30 days None reference Current 3.4 2.58-4.54 Prescription Opioid Misuse No reference Yes 3.1 2.50-3.72 Screen time <2h per day reference >2h per day 1.6 1.03-2.54 REFERENCES ACKNOWLEDGEMENTS • Aacap. (n.d.). Screen Time and Children. • Blanco, C., Flórez-Salamanca, L., Secades-Villa, R., Wang, S., & Hasin, D. S. (2018). • Centers For Disease Control and Prevention. (2023). • Connolly, S., Govoni, T. D., Jiang, X., Terranella, A., Guy, G. P., Gr | poster |
UNAVCO VIVO ingest (python scripts) Curated author disambiguation Disambiguation Match List VIVO Triple Store Check for existing objects in VIVO using VIVO Query API Get metadata from CrossRef using CrossRef API Employees MS Dynamics Membership xml ORCID Datasets UNAVCO API (in development) Abstracts web scraping > json RDF Publications Web of Science Google Scholar 0% 25% 50% 75% 100% Connect with social media databases that contain information about the researcher (e.g. Research Gate, LinkedIn, Twitter, Facebook) Generate biographies, CVs, resumes or other information Connect to institutional web page Be discoverable (efficiently and accurately) in Google or other search engines Which other features would you like an information platform that displays/describes your work to have? Not essential, should not be added Not essential, but could be added Important Very Important 0% 25% 50% 75% 100% Podcasts produced Meetings attended Past professional volunteer services/leadership positions Teaching tools produced Videos produced Webinars/workshops taught Presentations given Past grant awards Courses taught Students advised Software tools produced Algorithms/models developed Images/graphics created Professional awards received Instruments/tools developed Datasets produced Which of the following “products” are most important to include in an information platform that displays/describes your work (e.g. on a faculty webpage or in a researcher profile)? Ask a colleague Web sites of individual researchers Institutional library catalog Literature indexes, e.g. Web of Science Google or another search engine How do you search for publications? Never Sometimes Often Always Social/researcher networking services (e.g. Research Gate, LinkedIn, Facebook) Ask a colleague Published literature, e.g. journal articles University web sites Google or another search engine How do you search for people (e.g. a colleague who may have moved from one university to another)? 0% 25% 50% 75% 100% Institutional library catalog Ask a colleague Google or another search engine Published literature, e.g. journal articles Data center web sites How do you search for data (e.g. All time series from GPS stations in southern California)? Company or tool- producer web sites Institutional library catalog Ask a colleague Published literature, e.g. journal articles Google or another search engine How do you search for tools (e.g. all geodetic and seismic instruments in or around the Marmara Sea)? Figure 2 (above): The VIVO application comes pre-packaged with an ontology (semantic vocabulary) that doesn’t cover many geodetic concepts. Figure 2 illustrates a relationship not fully supported in the VIVO-ISF ontology. A project will have many stations which may host multiple instruments (e.g. GPS and meteorological equipment), which are attached to one or more platforms (see Figure 3 for an example). Figure 4 (above): Datasets can be linked to a major geophysical event, such as an earthquake. The products shown, and others such as software and models, are tied to skos:Concepts, which are pulled from controlled vocabularies whenever possible. Geodesy-specific concepts were added to the application to capture research areas and expertise. The VIVO application was customized to better capture the needs of the geodesy community. The customizations implemented so far include ontology extensions and mapping capabilities. For the initial rollout, the database was populated from a diverse array of sources, summarized below (Figure 5). As the application matures, relevant data will be added automatically using APIs from the NSF, ORCID, and CrossRef. Guiding development of a semantic web app: End-user engagement in the EarthCollab project Gross, M. Benjamin1, Johns, Erica M.2, Rowan, Linda R.1, Mayernik, Matthew3, Khan, Huda2, Daniels, Michael D.3, Krafft, Dean B.2 1) UNAVCO, Boulder, CO 2) Cornell University, Ithaca, NY 3) National Center for Atmospheric Research, Boulder, CO This materi | poster |
Lost in scientific literature? Too busy to stay on top of your field? Find influential research with a click of a button. Get to highly cited articles, follow updates on new publications, browse grant database to see what is funded in your field. Too few or too many results, having to search in numerous places - literature research can be time-consuming. Europe PMC provides free access to biomedical peer-reviewed publications and offers advanced search tools to help you navigate the world of scientific knowledge. Try Europe PMC for A-Z of life sciences literature: publications, patents, theses, and more. It combines the power of PubMed and PMC with a single search for both abstracts and full text. Even most specific requirements can be addressed with Europe PMC advanced search. Find clinical reviews, or search specifically for articles that mention CRISPR in the methods section. Hard to locate primary data and find evidence? Want to re-use a dataset from a study? Discover links to data records directly from the full text. Europe PMC links to PDBe, UniProt, ChEMBL, and many more public molecular resources. Looking for evidence to support your hypothesis? Scan articles for concepts like chemicals or organisms, and spot protein interactions or gene-disease relations with an annotation tool. No time to gather the evidence of your impact? Claim your works to your unique ORCID identifier with a simple tool from Europe PMC and enjoy immediate benefits - an Author Profile showcasing your publication list and citation rate. Find your way with Europe PMC! www.europepmc.org | poster |
Experiment 1: 4 Amaranthaceae species & Glycine max • The study was conducted at the following field sites in southern Illinois: Cypress Creek National Wildlife Refuge (A. japonica), Chestnut Hills Nature Preserve (A. japonica), Belleville Research Center (A. palmeri, A. tuberculatus, G. max), and Beall Woods State Park (I. rhizomatosa). • Ten individual plants of each species at each site were randomly selected for measurements (see Sampling Method above). • Differences among wavelengths in % reduction taking into account plant height as a covariate were tested using an ANCOVA in SAS. Experiment 2: Achyranthes japonica in competition with Microstegium vimineum • The field site was located at Chestnut Hills Nature Preserve in Pulaski County, Olmsted, Illinois. • Twenty 1m2 quadrats containing mixed communities of A. japonica and M. vimineum with different proportions of A. japonica were sampled three times (T1, T2, T3) during July. • Vegetation was sampled by visually estimating plant cover in each 1m2 quadrat based upon the modified Daubenmire method for cover estimation. • Four individual plants within each plot were randomly selected for measurements (see Sampling Method above). • The relationship between the proportion of A. japonica and height to the mean % reduction of each light wavelength was examined using a stepwise regression in SAS. Introduction Materials and Methods Experiment 1 • All five species had significant differences between light wavelengths (Fig. 1). • The mean % reduction of the blue wavelength was consistently the highest among the four wavelengths, nearing 100%, followed by the red and far-red wavelengths, respectively (Fig. 1). • The far-red and white wavelengths had similar levels of reduction at approximately 44% in A. japonica at Cypress Creek and 59% in I. rhizomatosa, (Fig. 1a, e), while A. japonica at Chestnut Hills had a greater reduction in the white than far-red wavelength (Fig. 1b). Experiment 2 • There was a positive relationship between the mean % reduction in both the blue and red wavelengths and height for T1 and T3 (Fig. 2a, c). • There was a negative relationship between the mean % reduction in the far-red wavelength and the proportion of A. japonica for T1 (Fig. 2b). • There was a positive relationship between the red:far-red ratio and height for T1 and T2 (Fig. 2d). • There was a negative relationship between the mean % reduction of red wavelength and the proportion of A. japonica and a positive relationship with height for T2(Fig. 2e). • There were no significant relationships detected for the white wavelength. a) Blue Wavelength (Height) Height (cm) 20 30 40 50 60 70 80 90 100 Mean % Reduction 96.0 96.5 97.0 97.5 98.0 98.5 99.0 99.5 100.0 Time 1: blue = 97.666 + 0.01798 (height) F1,18 = 8.44, p = 0.0094, R2 = 0.3192 Time 3: blue = 97.744 + 0.01443 (height) F1,18 = 5.16, p = 0.0356, R2 = 0.2229 40 50 60 70 80 90 100 40 50 60 70 80 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 Mean % Reduction Height (%) Proportion of Achyranthes japonica e) Red Wavelength (Height & Proportion of Achyranthes japonica) 40% 50% 60% 70% 80% 90% 100% Time 1 Time 1 Regression Time 2 Time 2 Regression Time 3 Time 3 Regression c) Red Wavelength (Height) Height (cm) 20 30 40 50 60 70 80 90 100 Mean % Reduction 40 50 60 70 80 90 Time 1: red = 44.248 + 0.44211 (height) F1,18 = 11.35, p = 0.0034, R2 = 0.3868 Time 2: red = 60.15926 - 9.66842 (propachj) + 0.34795 (height) F2,17 = 9.8; p = 0.0015; R2 = 0.5354 Time 3: red = 56.29869 + 0.25306 (height) F1,18= 11.79, p = 0.0030, R2 = 0.3958 b) Far-Red Wavelength (Proportion of Achyranthes japonica) Proportion of Achyranthes japonica 0.2 0.4 0.6 0.8 1.0 Mean % Reduction 35 40 45 50 55 60 65 70 Time 1: far-red = 53.72696 - 9.15980 (propachj) F1,18 = 6.00, p = 0.0248, R2 = 0.2501 d) Red:Far-Red Ratio (Height) Height (cm) 20 30 40 50 60 70 80 90 100 Red:Far-Red Ratio 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 Time 1: ratio = 0.85063 + 0.01217 (height) F1,18 = 7.63, p = 0.0128, R2 = | poster |
NHS East Genomics has 4 main partner NHS Trusts: Cambridge University Hospitals | Norfolk and Norwich University Hospitals Nottingham University Hospitals | University Hospitals of Leicester www.eastgenomics.nhs.uk Learning from the implementation of DPYD pharmacogenetic testing across 18 acute NHS Trusts Authors: Aris Saoulidis1, Paul Selby1, James Drummond1, Sarah Hunter1, Colin Spencer1, Sarah Pacey1, Richard Sandford1 1NHS East Genomic Medicine Service Alliance & Genomic Laboratory Hub (East Genomics). Correspondence: Aris.Saoulidis@nhs.net Informatics interoperability between genetic labs and prescribing software is key Clinical teams have no or limited functionality to seamlessly track the test progress, and test results are primarily transferred as PDF reports. Current manual methods of tracking and reporting test results to clinicians contribute to perceived longer test turnaround times by clinicians, despite timely lab reporting. Thus, automated reporting between NHS systems is needed. The current healthcare informatics exchange standards and channels (HL7 and FHIR) offer opportunities to support PGx interoperability.4 However, the community requires consensus on standardising the nomenclature of PGx reporting to clinicians agnostic to prescribing systems. Currently, Ontology and Medical terms (SNOMED CT) are not aligned with clinical PGx guidelines, introducing challenges of clinical PGx reporting, as for example, the UK Chemo Board guidance have six levels of DPD classification as opposed to three SNOMED CT codes. Figure 1: Number of medicines with pharmacogenomic potential prescribed by pharmaceutical class Patient outcomes and data collection Interoperability will support systematic data collection needed on treatment efficacy and toxicity for large scale adoption of PGx. Finally, we welcome the community’s approach to further identify how to increase and review systematic toxicity reporting, alongside re-assessment of expanded testing for other DPYD variants across different ethnicities. Background Fluoropyrimidines (capecitabine, 5-fluorouracil/5FU) are systemic anti-cancer therapy (SACT) in solid cancer. Fluoropyrimidines are metabolised by the enzyme dihydropyrimidine dehydrogenase, encoded by the DPYD gene. Pre-treatment genetic screening for DPYD pharmacogenetic (PGx) variants can predict and prevent fluoropyrimidine toxicity and was mandated prior to 5FU/capecitabine treatment by the MHRA in October 20201; a Clinical Commissioning Urgent Policy Statement was published by NHS England in November 20202. DPYD testing already takes place across 18 East of England and East Midlands NHS Trusts offering fluoropyrimidine systemic anti-cancer treatment, albeit with significant variation. Most Trusts are currently following the UK Chemotherapy Board’s 2020 Personalised Medicine Approach for fluoropyrimidine-based therapies3. Overall, DPYD testing is now established in the NHS, preventing toxicity and improving treatment for patients with clinically-significant DPYD variants. We share our key learnings from the East Genomics DPYD transformation project. 1. 5-fluorouracil (intravenous), capecitabine, tegafur: DPD testing recommended before initiation to identify patients at increased risk of severe and fatal toxicity. Medicines and Healthcare products Regulatory Agency. October 2020 accessible from https://www.gov.uk/drug-safety-update/5-fluorouracil-intravenous-capecitabine-tegafur-dpd-testing-recommended-before-initiation-to-identify- patients-at-increased-risk-of-severe-and-fatal-toxicity 2. Clinical Commissioning Urgent Policy Statement Pharmacogenomic testing for DPYD polymorphisms with fluoropyrimidine therapies– NHS England, November 2020 (URN 1869) accessible from: https://www.england.nhs.uk/publication/clinical-commissioning-urgent-policy-statement-pharmacogenomic-testing-for-dpyd-polymorphisms-with-fluoropyrimidine-therapies/ 3. Personalised Medicine Approach For Fluoropyrimidine-based Therapies. UK Chemother | poster |
Research Libraries have a long history of studying the users of their collections, but these theories and methods have not translated easily into stud- ies of digital services, much less of digital data services. By combining information from DANS transaction logs with a user database we gain insights into who uses the archive and how. Curation Images form the largest part of the archived files. Most of them stem from archeological data- sets. One of the biggest challenges in long-term preserva- tion is to still be able to read/display digital content - file type recognition is a prerequisite. Monitoring of the amount of datasets, their composition in terms of files, file size, and file type is needed to design strategies for storage and access. Here we show a polar bar chart of mime type frequencies (above) and the growth of the archive (below). Datasets with a later creation date have more files, and there are more datasets each year. Before 2000 the archive grew yearly by less than 2 GB. After 2000 we observe a dramatic change in the growth regime, adding between 100 and 500 GB each year. Navigation From the transactions logs, we extracted the 70 most frequently used search terms across all sessions. Clustering strings reveals groups of topics: archeological sources (see cluster 1-4), elections (*kiezer*), mobility (*mobiliteit*), or living conditions (*woon*). OPACs (Online Public Access Catalogue) determine how the user sees the collections of a digital library or archive. Visualizations of a collection can bridge the gap between the old physical and the new digital. But what to visualise? Geographic regions and periods in time? The interconnectedness of search terms and their possible targets or the composition of the collection in terms of targeted audiences? As of May 2015, EASY contains 29,743 published datasets (the equivalent of a “collection” in Dublin Core ). The majority of submitted datasets originate in archaeology, for which EASY is a legal deposit archive. The majority of downloaded datasets are from the social sciences. See a showcase of a visual exploration of EASY at: http://www.drasticdata.nl/projects.htm#DansEasy Christine Borgman, Andrea Scharnhorst, Henk van den Berg, Herbert Van de Sompel, Andrew Treloar christine.borgman@ucla.edu, andrea.scharnhorst@dans.knaw.nl, henk.van.den.berg@dans.knaw.nl, herbertv@lanl.gov, andrew.treloar@ands.org.au Surprisingly little is known about the uses and users of digital data archives, about relationships between users and the staff of data archives, or how these behaviors vary by discipline, geographic region, policy, and other factors. Digital data archives are not a single type of institution - they vary widely in organizational structure, mission, collection, funding, and relationships to their users and other stakeholders. We present an exploratory study of EASY, the Electronic Self-Archiving SYstem, a digital archive hosted at DANS. DANS was founded in 2005 as an institute of the Royal Netherlands Academy of Arts and Scienc- es (KNAW) and of the Netherlands Organisation for Scientific Research (NWO). DANS is responsible for archiving 50 years of digital research data in the social sciences and humanities. We present a number of visual explorations with the goal of identifying methods for studying the contributors, consumers, and role of archivists in digital data archives. In particular we address RESEARCH about users; CURATION of digital content, and interfaces for NAVIGATION. [1] Christine L. Borgman, Andrea Scharnhorst, Henk van den Berg, Herbert Van de Sompel, and Andrew Treloar. "Who Uses the Digital Data Archive? An Exploratory Study of DANS" Information Today (2015). ! magnitude: 1000, 100, 10, 1 users sessions Number of logged in users and sessions, world!wide, 2011 ! 2014 ! magnitude: 1000, 100, 10, 1 users sessions Number of logged in users and sessions, 2011 ! 2014 !"##$"%&' (#$)* *+,-.(%$, -..+-.++*-" /-#'. .$.)#0".+-.#1%!"*-%0.)#%'#$!%. .-01#*)*,%# .-01.#*) | poster |
Biological processes underpinning soil ecosystem services Methods Preliminary assessment A summary report, Soil Ecosystem Services: the current status and research priorities (Paterson, Glies, Yeluripati & Neilson, 2022) was completed, identifying knowledge-gaps with respect to biologically mediated processes underpinning soil ecosystem services. This report also identified research within the current RESAS Strategic Research Programme contributing to understanding of soil ecosystem services, and how this research links to current policy for soil governance in Scotland. Experimental approach Soils representing a diversity of classifications across cultivated land in Scotland were identified, including long-term experimental sites, where land use and management are known and supported by existing monitoring data. A set of approaches to quantify soil biological functions were applied, focusing on processes underpinning greenhouse gas fluxes, nutrient cycling, crop productivity and nitrogen leaching. The biological functions were selected, both for their direct relevance to soil ecosystem services, and as functions that are represented in biogeochemical models (i.e., the data will support refinement of these models). Results Example of soil functional analysis: Balruddery Centre for Sustainable Cropping Sustainable management, reduced tillage and application of organic amendments to substitute for mineral fertilisers, significantly affected microbial community abundance and composition, strongly impacting the physiological capacity of the soil microbiome to utilize a diversity of organic compounds (Fig. 1). Eric Paterson and Clare Cameron The James Hutton Institute, Craigiebuckler, Aberdeen Email: eric.paterson@hutton.ac.uk Introduction • Soil is a fundamental resource supporting delivery of ecosystem services underpinning societal, environmental and economic benefits. • Historically, these benefits have been linked closely to soils’ capacity to sustainably support plant primary production for food, fibre, and fuel, thereby supporting human life and activities. • These provisioning services remain vital, particularly in the context of increasing global populations, a changing climate and competing pressures on land use. However, a host of other services that soils provide are now recognised to underpin environmental and cultural services that need to be considered in management and policy decisions relating to soils and land use. • The soils of Scotland are highly diverse, shaped by climate and their underlying geology, meaning that the ecosystem services that they can potentially support is variable. • Management of soils for single ecosystem services (e.g., greenhouse gas mitigation) has consequences for others (e.g., food production), and understanding these potential trade-offs, across diverse soils, is a focus of this research. Conclusions The desk review of existing knowledge on soil ecosystem services identified successful use of soil properties to predict services that are primarily controlled by physico-chemical processes (e.g., resistance to erosion, water infiltration), but that prediction of biologically-driven functions (e.g., greenhouse gas fluxes, nutrient cycling), is more difficult, particularly in the context of dynamic changes associated with management practices. The soil functional analyses identified strong soil-type effects on biological processes, and that for a single soil, management has a significant impact on the capacity of that soil to mediate processes underpinning greenhouse gas fluxes, element cycling, plant productivity and nutrient retention. Figure 1: Canonical Analysis of Principal Coordinates (CAP) of soil microbial community physiological diversity (MicroRespTM) for conventional (CON) and sustainable (SUS) management practices. These impacts of sustainable management practices on microbial communities were associated with significant effects on soil functions affecting nitrogen availabil | poster |
H63D Research Consortium Konferenzposter www.H63D.org Nur für akademische Zwecke! Typ 1, 2 & Oshtoran H63D-Syndrom Typ-1 H63D Syndrom Typ-1 führt zu einer spezifischen Konstellation: niedriges Ferritin und hohe Transferrinsättigung, was zu einer Speicherung von nicht entfernbarem NTBI (nicht an Transferrin gebundenem Eisen) führt. Diese intrazelluläre NTBI- Akkumulation verursacht zunächts unbemerkt subklinische Entzündungen, die wiederum zu ersten Funktionsstörungen, aber auch bereits zu meist erheblichen Organschäden führen können, insbesondere an Leber, Herz, Endokrinium und Gehirn. Typische Symptome basieren somit auf nur mit sehr speziellen Tests fassbaren subklinischen Entzündungen, ungleich verteilt im Parenchym, oft bereits früh begleitet von einer schleichenden Degeneration der Hoden, was zu Verkalkungen führen kann. Zudem treten Narkolepsie mit Kataplexie und nahezu die gesamte Palette der so genannten non-motor Parkinson Symptome auf (wenig überraschend beim Vorliegen einer Degeneration der Substantia nigra mit Bezug zu den Basalganglien). Vor Chelattherapien aller Art und Aderlässen muss gewarnt werden, da sie das Ferritin weiter reduzieren, während das toxische NTBI-Eisen im Körper verbleibt. H63D-Syndrom Typ-2 Typ-2 zeigt einen unspezifischeren Phänotyp mit einem bunten Strauß an Symptomen und erfordert eine ausgesprochen umfassende Diagnostik durch Endokrinologen. Die Eisenregulation und dessen Auswirkungen auf den Körper sind jedoch auch hier der Kern des Problems. Die Anwendung von Aderlässen hängt vom Ferritinwert ab und muss sorgfältig überwacht werden. H63D-Syndrom Typ-3 Oshtoran-Syndrom Das Oshtoran-Syndrom (H63D Typ-3) beginnt mit einer immunologischen Schädigung (progressiv, persistierend) nach einer Infektion, insbesondere nach dem PANS/PANDAS Syndrom. Die in der Folge klinisch aktivierte homozygote HFE H63D Mutation führt langsam aber sicher zu Symptomen, die jenen von Typ-1 ähnlich sind, doch erheblich radikaler und persistierender. Typisch für Typ-3 (Oshtoran) ist eine wellenrtige Progredienz mit teils vital gefährlichen Symptomen. Wie auch bei dem o.g. Typ-1 kommt es wellenartig zunehmend zu ernsten Organschäden (strukturell und funktionell). Merwürdig oft findet man in der Leber eine FNH. In den fortgeschrittenen Stadien tritt oft eine PDH- Zytopathie (eine Mitochondriopathie) auf. Die durch ANS/ZNS, Pathways, Botenstoffe und zusammen über die Innervation auslösbaren Fehlsteuerungen von Organen, Endokrinium und Immunsystem macht das Oshtoran Syndrom zu einem potentiell letal endenden, äußerst schwer diagnostizierbaren und nicht kausal behandelbaren Phänotyp. Daher ist die Behandlung fast immer nur supportiv und nicht kurativ, mit außerordentlich starker Medikation. H63D-SYNDROM Eine der riskantesten Orphan Diseases kondensiert für Laien und Eilige erklärt. Das H63D-Syndrom Das H63D-Syndrom ist eine genetische Erkrankung, die durch eine homozygote Mutation im HFE-Gen H63D verursacht wird. Diese Mutation kann in seltenen Fällen zu einer Vergiftung durch NTBI-Eisen führen, wie dies in sehr ähnlicher Weise beim Morbus Wilson mit Kupfer geschieht. Eine Vielzahl von immer schlimmer werdenden Funktions- und Organschäden ist die Konsequenz. Auch hier die Parallele zum Morbus Wilson. Im Gegensatz zu herkömmlichen Formen der Eisenüberladung (das H63D- Syndrom ist keine Hämochromatose) die durch hohe Ferritinwerte gekennzeichnet sind, zeichnet sich das H63D-Syndrom durch niedriges Ferritin und eine erhöhte (>50%, meist >60%) Transferrinsättigung aus. Dies führt bei jedem Menschen zur Bildung von toxischem NTBI-Eisen und folglich zu einer Ablagerung von NTBI-Eisen in kritischen Organen wie z.B. Leber, Herz und Gehirn. In kleinen Mengen ist dies normal, kann aber erhebliche Folgen haben, wenn man zu lange (meist Jahre) zu viel NTBI in seinen Parenchymzellen und Gehirn speichert, wie dies am H63D-Syndrom Erkrankte erleben. Meist leiden die Patienten daher über Jahre hinweg an immer mehr Symptomen: 50 bis 90 sind | poster |
Combined effects of alternative casing materials and biostimulants on Agaricus bisporus yield and disease incidence Florien A. Gorter1, Marc Hendriks1, Odette Mendes1, Carin Lombaers1, Marjon Krijger1, Ed Hendrix1, William Kay2, Gail Preston2, Jaime Carrasco2,3, Pablo Martinez3, and Jean M. van der Wolf1 1 Wageningen University and Research, Biointeractions and Plant Health, Wageningen, NL, 2 University of Oxford, Department of Plant Sciences, Oxford, UK, 3 Mushroom Technological Research Center of La Rioja (CTICH), La Rioja, Spain Background Casing soil is a complex substrate that is essential for the fructification of Agaricus bisporus mushrooms. Currently, casing soil mainly consists of peat, which is used because of its excellent physical, chemical and biological properties. However, peat excavation is associated with CO2- emissions and biodiversity loss. As such, the mushroom industry is looking for alternative casing materials that can be used to—partially or wholly—replace peat. We identified materials that can be used to partially replace peat without major negative effects on mushroom yield or disease incidence. Performance of alternative casing materials might be improved by the addition of beneficial microbes. Bacterial strains from peat have been isolated that potentially enhance fructification of the mushroom crop. Strains have also been identified that selectively inhibit fungal pathogens such as Lecanicillium fungicola (dry bubble disease) in vitro. Addition of selected biostimulant strains might thus help to overcome the drawbacks associated with the use of alternative casing materials and reduce the use of pesticides. Results Objective Experimental set-up Conclusions • Biostimulants had no effect on yield or dry bubble disease incidence. • Biostimulant A was able to persist in casing soil during two flushes. • Biostimulant B populations decreased rapidly in casing soil. Button mushrooms were grown on three different casing soils (peat, alternative I and alternative II) under standard conditions in an experimental mushroom facility for two consecutive flushes. Mushroom yield was determined in the absence vs. presence of biostimulants A, B or a mix of A, B, and C. Disease incidence following inoculation with Lecanicillium fungicola was determined in the absence vs. presence of biostimulants A, B or a mix of A, B, and C. Population dynamics of biostimulants A and B in the absence of Lecanicillium was determined using targeted TaqMan qPCR assays. Acknowledgements The work presented here was performed as part of the H2020 BIOSCHAMP project (Grant Agreement 101000651), which aims to take an integrated approach to tackle mushroom cultivation challenges. BIOSCHAMP partners are: the Spanish Associations of Mushroom Growers (ASOCHAMP), Research Center of Mushrooms (CTICH), Inagro vzw, Wageningen Research, IRNASA-CSIC, University of Oxford, Kekkilä- BVB, NEWFOSS, FERTINAGRO, EUROCHAMP, UGLK, EKOFUNGI and Innovarum. Wageningen University & Research P.O. Box 123, 6700 AB Wageningen Contact: florien.gorter@wur.nl T + 31 (0)317 48 44 45 Figure 4. Population dynamics of biostimulants in the absence of Lecanicillium fungicola. Absolute abundance determined using TaqMan assays. Ct = cycle threshold, i.e. number of PCR cycles required for the fluorescent signal to cross the threshold. Detection threshold: 35. Biostimulants were added at the beginning of the 1st and 2nd flush (orange arrows) and sampling was performed at multiple time points during the flushes. A) Biostimulant A. B) Biostimulant B. 0 5 10 15 20 25 30 35 40 45 T0 T1 T2 T3 T4 T5 T6 T7 Ct Sampling timepoints A 0 5 10 15 20 25 30 35 40 45 T0 T1 T2 T3 T4 T5 T6 T7 Ct Sampling timepoints B Figure 1. A) Agaricus bisporus growing in the experimental mushroom facility. B) Lecanicillium fungicola (dry bubble disease) causes deformations and brown spots on the mushroom (pictures from Berendsen et al., 2010, A = healthy, B-D = diseased). A B Figure 2. Effect of biostimulants | poster |
How does this discipline interpret the question? What methods would this discipline use to investigate the question? How would (someone in) this discipline know they had a good answer? Helping Hands… What expertise/ methods/norms of thought can you draw on from other disciplines to support or contrast? Additional notes. 3 Building Permeable Classroom Walls: Forming links across the curriculum What is the misperception/ boundary/ epistemology you are trying to address? Can this be checked in another classroom? Will the session(s) be co-taught? Taught separately across subjects? Draw on knowledge from other subjects Building on Current Practice 5-minute lesson plan – bridging subject boundaries Developing Epistemic Insight: How can the students be supported to answer these three questions? What is the Big or Bridging Question? Learning Objectives: Before they investigate, what Do they already need to know? How does this map on to other areas of the school curriculum? Is this building on existing knowledge? Challenging misperceptions? Acting as extension? 1 2 How ‘Green’ are electric cars? Science: Identify how fuel production is sourced RE/Stewardship: Discuss who holds responsibility and who we are responsible to and why when mining resources and taking care of the environment. Geography: Investigate the location of where fuel resources are mined Identify previous learning/gaps in learning. Science: batteries, electrolysis, disposal, rare resources/recycling RE/Stewardship: The ethics of enforcing electric cars Geography: Location of resources Economics: Affordability, Accessibility (Market forces) Science: Establishing sources for electricity (fossil fuels/renewables) and how they are mined, pollution RE/Stewardship: Consider who benefits and who is disadvantaged from electric car production (inc sourcing materials). Awareness of demand on resources, production processes, politics, monopolise materials. Science: Undertake reliable tests, and reproducible experiments. Field studies. RE/Stewardship: Investigate the impact on quality of life (i.e. emissions, noise, global versus local perspective, impact on wildlife, rights of individuals, changes to/effects on societal behaviour Science: Reliable data checked against wider sources (misperceptions by car co’s). Replicable and tested by multiple sources. RE/Stewardship: Focus on judgements, beliefs and values in religious texts, ethical principles. Justifying actions from religious texts or worldviews. Geography – location of resources, damage to the environment, impact on local population. Geography – fieldwork, data analysis focused on people, places and spaces. Geography (physical and human) - data collection is both quantitative (mapping, surveys) and qualitative (interviews). Is this purely a science question? Are the environmental benefits of electric cars overstated? Collaborate with teachers of other disciplines. Learn from colleagues by talking about the same topic/big question and share their expertise and space to break down classroom boundaries. Co-planning/co-teaching with other subject specialist to work on the same topic/question from various disciplinary perspectives. | poster |
In this work, the drawings collected from healthy individuals and people with PD were classified by RFC. The proposed method employed pencil drawings digitized from ordinary sheet of paper, making it very simple to be applied in the context of scarce financial resources. Despite the small number of images in the available data set (51 per class), the obtained results were satisfactory and accurate by discriminating drawings of healthy people from those with PD. HOG parameters were tested in default values (10x10 pixels per cell, 2x2 cells per block and 9 bins in the histogram with 0-180° orientation) focus on good performance showed by Dalal and Triggs [4] and the HOG result was passed to the classifier. This is the first reported study considering the application of HOG estimates in combination with the RFC applied to the automatic classification of data obtained from people with PD. In the future, it will be necessary to obtain more image drawings and different shapes to increase the database and test more parameters. ACKNOWLEDGEMENTS DISCUSSION AND CONCLUSION Parkinson’s disease (PD) is a neurological disorder that is progressive and causes losses of dopaminergic neurons from the substantia nigra, a region in the human brain. The decrease of dopamine in this area implies the worsening of motor symptoms such as tremors, bradykinesia, rigidity, gait impairment, and non-motor symptoms such as depression, loss of cognitive functions, sleep problems and nerve pain [1]. PD affects 1% of the world’s population aged 60 years and over, and despite scientific advancement, the disease remains incurable. The diagnosis of PD is complex, with a seasoned specialist being necessary to make it [1, 2]. Tremors are a common symptom in PD and it can be classified into many types: resting tremor, postural tremor, kinetic, essential, cerebellar, and others. Each type manifests in different situations and frequency ranges [3]. This work proposes to classify images of handwritten drawings collected from healthy individuals and people with PD. The identification and discrimination of motor symptoms in PD is a fundamental step in the diagnosis and follow-up of the disorder. INTRODUCTION 1. de Lau LM, Breteler MM (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535. doi: 10.1016/S1474-4422(06)70471-9 2. Cancela J, Mascato SV, Gatsios D, et al (2016) Monitoring of motor and non-motor symptoms of Parkinson’s disease through a mHealth platform. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. IEEE, pp 663–666 3. Andrade AO, Pereira AA, Almeida MFS de, et al (2013) Human Tremor: Origins, Detection and Quantification. In: Andrade AO (ed) Practical Applications in Biomedical Engineering. InTech, Croatia 4. Dalal N, Triggs B (2018) Histograms of Oriented Gradients for Human Detection. In: 2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR’05). IEEE, pp 886–893. The present work was carried out with the support of the National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel (CAPES – Program CAPES/DFATD- 88887.159028/2017-00) and the Foundation for Research Support of the State of Minas Gerais (FAPEMIG-APQ-00942-17). A. O. Andrade, A. A. Pereira and M. F. Vieira are a fellow of CNPq, Brazil (304818/2018-6, 310911/2017-6, and 306205/2017-3). RESULTS REFERENCES The Federal University of Uberlândia’s Research Ethics Committee approved the research under the number 07075413.6.0000.515. In the study, 51 images were collected from each group, i.e., healthy individuals and people with PD. A total of 102 images were available. MATERIALS AND METHODS Group Total Sex (F/M) Age (years) Health 12 8/4 60.08 ± 6.13 PD 15 7/8 65.33 ± 9.17 Fig. 1. (A) Samples of handwritten drawings collected from people with Parkinson’s disease (PD) and healthy individuals (H); (B) Pre-processed ima | poster |
According to Google: How does Google Images see and show climate change and biodiversity loss? Data collection Data curation Visualisation and Analysis The Google Images search engine is probably the most important online gatekeeper of visual culture worldwide, with over two billion searches conducted on the platform every day. Despite the platform’s importance, there is a scarcity of analyses on how Google determines the visibility of images within its search rankings. For example, is “authority” determined in a similar way to its textual web search results? Or do computer vision techniques offer new criteria for promoting images and the websites that host them? This research project focused on the visualisation of [climate change] and [biodiversity loss] by building a dataset of country-specific search rankings from Google Images. We scraped data from six different countries, selected for their political and geographic diversity in relation to the environment: Australia, Netherlands, Nigeria, China, Mexico and Brazil. We built on findings from a 2019 DMI Summer School project, Climate Image Spaces, that suggested Google Images shows a dehumanised visual vernacular of climate change dominated by landscapes, charts and the Earth. Google Images has a homogenising effect on the visual vernaculars of both climate change and biodiversity loss. For climate change, generic representations of climate change dominate. In particular, a small number of “iconic” stock images are highly ranked across the different countries. Many of these images have a half and half “left/right” layout suggesting the current, often dystopian, situation on the left, with a more hopeful utopian future on the right (occasionally this implied temporality is reversed). Examples of these images include “hand in earth”, “landscape” and “tree”. For biodiversity loss, there is also homogeneity, although with some greater country-specific diversity. Stock imagery is less dominant, but half and half images remain important, such as ‘forest as lungs’. Although biodiversity loss covers many different aspects of environmental degradation, the imagery focuses almost exclusively on deforestation. Images appear to be ranked on whether they “accord” with Google’s envisioning of climate change as time-less, place- less, human-less and cause-less. Websites not according to Google’s visions of climate change and biodiversity loss are unlikely to be ranked highly by Google Images. We used a Python script and VPNs to collect the top 50 images associated with [biodiversity loss] and [climate change] on Google Images for six countries: China, Brazil, Netherlands, Nigeria, Mexico. This resulted in a corpus of 300 images for each search term. We identified the most similar/mobile images across datasets using Google Cloud Vision, Clarifai and Memespector. Using vision APIs we identified labels and web entities associated with the images, which we used to gain a deeper understanding of the logic underpinning the sorting of images. Manual coding was then used to identify specific types of images which were not characterised by Google or Clarifai labels (e.g. half and half images, degraded forests). Using semiotics to inform our analysis manual coding served to differentiate between identical and similar images. Country specific datasets were then merged into a master spreadsheet for each term and used to identify top 10 images. We repeated the same process and expanded our data collection using the Search Engine Scraper developed by the DMI to scrape the top 10 ranking websites of Google. We extracted web domains and used the Triangulate tool to compare Google's Search and Images results in each country. Data and protocols were collated in a shared Google Drive folder. A range of tools were used for data collection, in particular a Python script and DownThemAll, and for data analysis: Clarifai, Cloud Vision, Memespector, Imagesorter, Rawgraph and Gephi. Data was centralised in csv for | poster |
MICROBIAL AND ANTIMICROBIAL RESISTANCE GENE DIVERSITY IN EXTRACELLULAR AND TOTAL DNA ACROSS RURAL ECOSYSTEM BARRIERS IN EUROPE Olivença D1, Cabal A2, Tenson T3, Hassan M4, Manageiro V1, Dias E1, Rosado T1, Kõiv V3, Kisand V3, Rab G5, Jeremejeva J6, Telling K3, Arbo K3, Chambers M4, Laragione R4, Voit E7, Drahošová Z8, Kořínková M8, Woegerbauer M9, Ruppitsch W2, Caniça M1, de Menezes A10 1National Institute of Health Dr. Ricardo Jorge – Lisbon, Portugal; 2Institute for Medical Microbiology and Hygiene, AGES-Austrian Agency for Health and Food Safety, Vienna, Austria; 3University of Tartu, Estonia; 4University of Surrey, Guildford, United Kingdom; 5Vienna University of Technology, Vienna, Austria; 6Estonian University of Life Sciences, Estonia; 7Georgia Institute of Technology and Emory University, Atlanta, USA; 8The National Institute of Public Health, Prague, Czech Republic; 9 Division for Risk Assessment, Data and Statistics, AGES - Vienna, Austria; 10National University of Ireland Galway, Galway, Ireland Aim: To determine the microbial community composition and antimicrobial resistance genes (ARGs) diversity in total and extracellular DNA in agricultural ecological compartments in Europe. This work is part of the OHEJP FED-AMR consortium, which aims to investigate the role of free extracellular DNA (exDNA) in the spread of AMR genes across ecosystem barriers via bacterial transformation. Methods: Sampling was carried out in Austria, Portugal Czech Republic, Estonia, UK and Ireland. Both total (tDNA) and extracellular DNA (exDNA) were extracted along one crop-growing season, and sequencing of the 16S rRNA genes and ARG-capture coupled with metagenomic sequencing were performed. Results: The 16S and ARGs sequencing results were obtained for 511 samples, including 258 exDNA samples. Naturally- transformable bacteria, capable of incorporating exDNA into their cells, were present in the samples. Conclusions: Further analyses will link microbiome and ARGs with contaminants, antibiotics, heavy metals and trace elements to better understand the importance of exDNA as a vector for AMR spread in agricultural ecosystems. WILD ANIMALS (faeces) PIG BARN (faeces, waste) Manure CROP FEED (on site/imported SOIL (different crops, fertilization WATER (field drainage) FARMERS (swab samples, faeces) WATER (surface, river, irrigation) WASTEWATER TREATMENT PLANT WATER (drinking, ground) Figure 2. Ordination plot of microbial diversity. Ecological compartment influenced microbiome and ARG diversity. Figure 3. ARG composition of exDNA of wastewater sludge from Ireland. Sludge exDNA had a large number of ARGs, showing their potential for ARG spread in the environment Figure 1. Possible routes of ARG spread across ecosystem barriers and targeted ecological compartments in FED-AMR Acknowledgements: This work was supported by funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 773830: One Health European Joint Programme; FED-AMR project. | poster |
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