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MT6235-MT6235-The MT6235 is a processor used in many Chinese cellular phones (eg. ZTE). It is a member of the MT62xx series of processors by MediaTek.
MediaTek-based Chinese cell phones often come with features not common to North American phones, such as analog television viewing and recording. While these phones have... | milkshake721/2.1M-wiki-STEM |
MT6235-Subsystems-Microcontroller Unit (MCU) Subsystem: includes an ARM926EJ-S RISC processor and its accompanying memory management and interrupt handling logics; Digital Signal Processor (DSP) Subsystem: includes a DSP and its accompanying memory, memory controller, and interrupt controller; MCU/DSP Interface: the ju... | milkshake721/2.1M-wiki-STEM |
MT6235-Sources-http://ryan.com.br/smf/index.php?topic=481.75;wap2 http://blog.csdn.net/sergeycao/archive/2008/08/26/2832568.aspx MT6235 GSM GPRS Baseband Processor Data Sheet_1.02.pdf https://web.archive.org/web/20160215061959/http://www.mediatek.com/en/products/mobile-communications/feature-phone/mt6235/ | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternatives to Darwinian evolution-Alternatives to Darwinian evolution have been proposed by scholars investigating biology to explain signs of evolution and the relatedness of different groups of living things. The alternatives in question do not deny that evolutionary changes over... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternatives to Darwinian evolution-Where the fact of evolutionary change was accepted but the mechanism proposed by Charles Darwin, natural selection, was denied, explanations of evolution such as Lamarckism, catastrophism, orthogenesis, vitalism, structuralism and mutationism (call... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternatives to Darwinian evolution-By the start of the 20th century, evolution was generally accepted by biologists but natural selection was in eclipse. Many alternative theories were proposed, but biologists were quick to discount theories such as orthogenesis, vitalism and Lamarc... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Unchanging forms-Aristotle did not embrace either divine creation or evolution, instead arguing in his biology that each species (eidos) was immutable, breeding true to its ideal eternal form (not the same as Plato's theory of forms). Aristotle's suggestion in De Generatione Animaliu... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Where the fact of evolutionary change was accepted by biologists but natural selection was denied, including but not limited to the late 19th century eclipse of Darwinism, alternative scientific explanations such as Lamarckism, orthogenesis, structu... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Vitalism Vitalism holds that living organisms differ from other things in containing something non-physical, such as a fluid or vital spirit, that makes them live. The theory dates to ancient Egypt. | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Since Early Modern times, vitalism stood in contrast to the mechanistic explanation of biological systems started by Descartes. Nineteenth century chemists set out to disprove the claim that forming organic compounds required vitalist influence. In ... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Orthogenesis Orthogenesis or Progressionism is the hypothesis that life has an innate tendency to change, developing in a unilinear fashion in a particular direction, or simply making some kind of definite progress. Many different versions have been... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Lamarckism Jean-Baptiste Lamarck's 1809 evolutionary theory, transmutation of species, was based on a progressive (orthogenetic) drive toward greater complexity. Lamarck also shared the belief, common at the time, that characteristics acquired durin... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Catastrophism Catastrophism is the hypothesis, argued by the French anatomist and paleontologist Georges Cuvier in his 1812 Recherches sur les ossements fossiles de quadrupèdes, that the various extinctions and the patterns of faunal succession seen... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Structuralism Biological structuralism objects to an exclusively Darwinian explanation of natural selection, arguing that other mechanisms also guide evolution, and sometimes implying that these supersede selection altogether. Structuralists have pr... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Saltationism, mutationism Saltationism held that new species arise as a result of large mutations. It was seen as a much faster alternative to the Darwinian concept of a gradual process of small random variations being acted on by natural selection.... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Alternative explanations of change-Genetic drift The neutral theory of molecular evolution, proposed by Motoo Kimura in 1968, holds that at the molecular level most evolutionary changes and most of the variation within and between species is not caused by natural selection but by gen... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Combined theories-The various alternatives to Darwinian evolution by natural selection were not necessarily mutually exclusive. The evolutionary philosophy of the American palaeontologist Edward Drinker Cope is a case in point. Cope, a religious man, began his career denying the poss... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Rebirth of natural selection, with continuing alternatives-By the start of the 20th century, during the eclipse of Darwinism, biologists were doubtful of natural selection, but equally were quick to discount theories such as orthogenesis, vitalism and Lamarckism which offered no mech... | milkshake721/2.1M-wiki-STEM |
Alternatives to Darwinian evolution-Sources-Birch, Charles; Cobb, John B. (1985). The Liberation of Life: From the Cell to the Community. University of North Texas. ISBN 978-0-9626807-0-0.
Bowler, Peter J. (1989) [1983]. The Eclipse of Darwinism: anti-Darwinian evolutionary theories in the decades around 1900. Johns Ho... | milkshake721/2.1M-wiki-STEM |
Street magic-Street magic-Street magic falls into two genres; traditional street performance and guerrilla magic. | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-The first definition of street magic refers to a traditional form of magic performance – that of busking. In this, the magician draws an audience from passers by and performs an entire act for them. In exchange, the magician seeks remuneration either by having a receptacle fo... | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-Street magic most often consists of what has been referred to in the past as "hand" or "pocket" magic, sleight of hand. Whether card magic or magic performed with coins, balls, scarves, or rope, even occasionally mentalism, regardless of the props involved, the ability to dra... | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-The famous Indian Mango Tree is an old and venerated trick as performed by street magicians of the past and while it is demonstrably not of the hand magic variety, it exemplifies the fact that even large stage sized illusions can be presented in the street. In the trick, the ... | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-Anthropologists chronicle this form of street magic from approximately 3,000 years ago – and there are records of such performers across the continents, notably Europe, Asia/South Asia and the Middle East. While it is a very old performing style, its history is not particular... | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-New York based artist and magician Jeff Sheridan is regarded as one of the pre-eminent U.S. street magicians to emerge from the surge in street performance artistry which began in the late '60s. He authored the 1977 book, Street Magic, taught Jeff McBride and allegedly was on... | milkshake721/2.1M-wiki-STEM |
Street magic-Traditional street performance-Yorkshire Egg Magic is a long practised form of traditional street magic in the UK.More recently, other performers have garnered accolades from the magic community for their contributions to the art. Jim Cellini (a.k.a. Richard Sullivan) has been a full-time street performer ... | milkshake721/2.1M-wiki-STEM |
Street magic-Guerrilla magic-The second category is more appropriately called "guerrilla magic". It is a relatively recent style of performing magic illusions where the magician performs a single trick or two in a public space (such as on a sidewalk) for an unpaying audience. The desired effect of this "hit and run" st... | milkshake721/2.1M-wiki-STEM |
Street magic-Guerrilla magic-This style of "street magic" is associated with David Blaine (who popularized the term) and more recently, Criss Angel, Derren Brown and Cyril Takayama. The format was developed to play well on television beginning with the 1997 ABC television special David Blaine: Street Magic. Many magici... | milkshake721/2.1M-wiki-STEM |
Slow order-Slow order-A slow order is a local speed restriction on a rail line that is set below the track's normal speed limit.
Slow orders are usually imposed by railway dispatchers for sections of track that are in some way deficient or when there is a requirement to perform maintenance on a section of railway.
Slow... | milkshake721/2.1M-wiki-STEM |
Slow order-Around the world-Croatia On Croatian Railways, slow order is signaled with the following signs:1 - Signal "Slow" (Croatian: Lagano) - round yellow board with a white border. This sign warns the train driver that he is approaching the part of the track where the slow order is installed. The board is placed at... | milkshake721/2.1M-wiki-STEM |
Slow order-Around the world-2 - Signal "Beginning of slow order" (Croatian: Početak lagane vožnje) - white alphanumeric number on a black square board - indicates the place of the start of slow order. The number on the board shows maximum permitted speed over the slow order section in kilometers per hour.
3 - Revocatio... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-Three-mirror anastigmat-A three-mirror anastigmat is an anastigmat telescope built with three curved mirrors, enabling it to minimize all three main optical aberrations – spherical aberration, coma, and astigmatism. This is primarily used to enable wide fields of view, much larger than possible ... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-Three-mirror anastigmat-A telescope with only one curved mirror, such as a Newtonian telescope, will always have aberrations. If the mirror is spherical, it will suffer from spherical aberration. If the mirror is made parabolic, to correct the spherical aberration, then it must necessarily suffe... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-History-Many combinations of three mirror figures can be used to cancel all third-order aberrations. In general these involve solving a relatively complicated set of equations. A few configurations are simple enough, however, that they could be designed starting from a few intuitive concepts. | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-History-Paul telescope The first were proposed in 1935 by Maurice Paul. The basic idea behind Paul's solution is that spherical mirrors, with an aperture stop at the centre of curvature, have only spherical aberration – no coma or astigmatism (but they do produce an image on a curved surface of ... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-History-Paul's idea was to start with a Mersenne beam compressor, which looks like a Cassegrain made from two (confocal) paraboloids, with both the input and output beams collimated. The compressed input beam is then directed to a spherical tertiary mirror, which results in traditional spherical... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-History-One way to look at this is to imagine the tertiary mirror, which suffers from spherical aberration, is replaced by a Schmidt telescope, with a correcting plate at its centre of curvature. If the radii of the secondary and tertiary are of the same magnitude, but opposite sign, and if the ... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-History-Paul–Baker telescope Paul's solution had a curved focal plane, but this was corrected in the Paul–Baker design, introduced in 1969 by James Gilbert Baker. The Paul–Baker design adds extra spacing and reshapes the secondary to elliptical, which corrects field curvature to flatten the foca... | milkshake721/2.1M-wiki-STEM |
Three-mirror anastigmat-Examples-The James Webb Space Telescope is a three-mirror anastigmat featuring an ellipsoidal primary, hyperboloidal secondary, and ellipsoidal tertiary.
The Euclid mission uses a Korsch telescope.
The "Cambridge University Three-Mirror Telescope". project includes a 100 mm working model built i... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-DDR SDRAM-Double Data Rate Synchronous Dynamic Random-Access Memory (DDR SDRAM) is a double data rate (DDR) synchronous dynamic random-access memory (SDRAM) class of memory integrated circuits used in computers. DDR SDRAM, also retroactively called DDR1 SDRAM, has been superseded by DDR2 SDRAM, DDR3 SDRAM, DD... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-DDR SDRAM-Compared to single data rate (SDR) SDRAM, the DDR SDRAM interface makes higher transfer rates possible through more strict control of the timing of the electrical data and clock signals. Implementations often have to use schemes such as phase-locked loops and self-calibration to reach the required t... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-DDR SDRAM-With data being transferred 64 bits at a time, DDR SDRAM gives a transfer rate (in bytes/s) of (memory bus clock rate) × 2 (for dual rate) × 64 (number of bits transferred) / 8 (number of bits/byte). Thus, with a bus frequency of 100 MHz, DDR SDRAM gives a maximum transfer rate of 1600 MB/s. | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-History-In the late 1980s IBM had built DRAMs using a dual-edge clocking feature and presented their results at the International Solid-State Circuits Convention in 1990.Samsung demonstrated the first DDR memory prototype in 1997, and released the first commercial DDR SDRAM chip (64 Mbit) in June 1998, follow... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Modules To increase memory capacity and bandwidth, chips are combined on a module. For instance, the 64-bit data bus for DIMM requires eight 8-bit chips, addressed in parallel. Multiple chips with common address lines are called a memory rank. The term was introduced to avoid confusion with chip... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Adding modules to the single memory bus creates additional electrical load on its drivers. To mitigate the resulting bus signaling rate drop and overcome the memory bottleneck, new chipsets employ the multi-channel architecture.
Note: All items listed above are specified by JEDEC as JESD79F. All... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-There is no architectural difference between DDR SDRAM modules. Modules are instead designed to run at different clock frequencies: for example, a PC-1600 module is designed to run at 100 MHz, and a PC-2100 is designed to run at 133 MHz. A module's clock speed designates the data rate at which i... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-JEDEC Standard No. 21–C defines three possible operating voltages for 184 pin DDR, as identified by the key notch position relative to its centreline. Page 4.5.10-7 defines 2.5V (left), 1.8V (centre), TBD (right), while page 4.20.5–40 nominates 3.3V for the right notch position. The orientation ... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Increasing the operating voltage slightly can increase maximum speed but at the cost of higher power dissipation and heating, and at the risk of malfunctioning or damage.
Capacity Number of DRAM devices The number of chips is a multiple of 8 for non-ECC modules and a multiple of 9 for ECC module... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Power consumption A test with DDR and DDR2 RAM in 2005 found that average power consumption appeared to be of the order of 1–3 W per 512 MB module; this increases with clock rate and when in use rather than idling. A manufacturer has produced calculators to estimate the power used by various typ... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Total module capacity is a product of one chip's capacity and the number of chips. ECC modules multiply it by 8⁄9 because they use 1 bit per byte (8 bits) for error correction. A module of any particular size can therefore be assembled either from 32 small chips (36 for ECC memory), or 16(18) or... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-DDR memory bus width per channel is 64 bits (72 for ECC memory). Total module bit width is a product of bits per chip and number of chips. It also equals number of ranks (rows) multiplied by DDR memory bus width. Consequently, a module with a greater number of chips or using ×8 chips instead of ... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-This example compares different real-world server memory modules with a common size of 1 GB. One should definitely be careful buying 1 GB memory modules, because all these variations can be sold under one price position without stating whether they are ×4 or ×8, single- or dual-ranked.
There is ... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Chip characteristics DRAM density Size of the chip is measured in megabits. Most motherboards recognize only 1 GB modules if they contain 64M×8 chips (low density). If 128M×4 (high density) 1 GB modules are used, they most likely will not work. The JEDEC standard allows 128M×4 only for registere... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Organization The notation like 64M×4 means that the memory matrix has 64 million (the product of banks x rows x columns) 4-bit storage locations. There are ×4, ×8, and ×16 DDR chips. The ×4 chips allow the use of advanced error correction features like Chipkill, memory scrubbing and Intel SDDC i... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Double data rate (DDR) SDRAM specification From Ballot JCB-99-70, and modified by numerous other Board Ballots, formulated under the cognizance of Committee JC-42.3 on DRAM Parametrics. | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-Standard No. 79 Revision Log: Release 1, June 2000 Release 2, May 2002 Release C, March 2003 – JEDEC Standard No. 79C."This comprehensive standard defines all required aspects of 64Mb through 1Gb DDR SDRAMs with X4/X8/X16 data interfaces, including features, functionality, ac and dc parametrics,... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Specification-1 GB PC3200 non-ECC modules are usually made with 16 512 Mbit chips, 8 on each side (512 Mbits × 16 chips) / (8 bits (per byte)) = 1,024 MB. The individual chips making up a 1 GB memory module are usually organized as 226 8-bit words, commonly expressed as 64M×8. Memory manufactured in this way ... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Generations-DDR (DDR1) was superseded by DDR2 SDRAM, which had modifications for a higher clock frequency and again doubled throughput, but operates on the same principle as DDR. Competing with DDR2 was Rambus XDR DRAM. DDR2 dominated due to cost and support factors. DDR2 was in turn superseded by DDR3 SDRAM,... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Generations-DDR's prefetch buffer depth is 2 (bits), while DDR2 uses 4. Although the effective clock rates of DDR2 are higher than DDR, the overall performance was not greater in the early implementations, primarily due to the high latencies of the first DDR2 modules. DDR2 started to be effective by the end o... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Generations-The DDR4 SDRAM is a high-speed dynamic random-access memory internally configured as 16 banks, 4 bank groups with 4 banks for each bank group for ×4/×8 and 8 banks, 2 bank groups with 4 banks for each bank group for ×16 DRAM. | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Generations-The DDR4 SDRAM uses an 8n prefetch architecture to achieve high-speed operation. The 8n prefetch architecture is combined with an interface designed to transfer two data words per clock cycle at the I/O pins. A single read or write operation for the DDR4 SDRAM consists of a single 8n-bit-wide 4-cl... | milkshake721/2.1M-wiki-STEM |
DDR SDRAM-Generations-Mobile DDR MDDR is an acronym that some enterprises use for Mobile DDR SDRAM, a type of memory used in some portable electronic devices, like mobile phones, handhelds, and digital audio players. Through techniques including reduced voltage supply and advanced refresh options, Mobile DDR can achiev... | milkshake721/2.1M-wiki-STEM |
Hydrogen highway-Hydrogen highway-A hydrogen highway is a chain of hydrogen-equipped public filling stations, along a road or highway, that allows hydrogen powered cars to travel. It is an element of the hydrogen infrastructure that is generally assumed to be a pre-requisite for mass utilization of hydrogen cars. For i... | milkshake721/2.1M-wiki-STEM |
Hydrogen highway-Supply issues, cost and pollution-Hydrogen fueling stations generally receive deliveries of hydrogen by tanker truck from hydrogen suppliers. An interruption at a hydrogen supply facility can shut down multiple hydrogen fueling stations. A hydrogen fueling station costs between $1 million and $4 millio... | milkshake721/2.1M-wiki-STEM |
Hydrogen highway-Existing public stations-Asia At the end of 2012 there were 17 private hydrogen stations. In 2014, Japan got its first commercial hydrogen fueling station.As of June 2020, there were 178 publicly available hydrogen fuel stations in operation in Asia. 114 of these were in Japan.
Europe As of November 20... | milkshake721/2.1M-wiki-STEM |
Hydrogen highway-Existing public stations-United States In 2013, The New York Times reported that there were "10 hydrogen stations available to the public in the United States: one in Columbia, S.C., eight in Southern California and the one in Emeryville, California". As of September 2022, there were 54 publicly access... | milkshake721/2.1M-wiki-STEM |
Purse accessories-Purse accessories-Purse accessories are fashion accessories that are made specifically for handbags, to enhance their functionality or appearance. | milkshake721/2.1M-wiki-STEM |
Purse accessories-Purse rain cover-Purse rain covers, also widely known as Purse Raincoats, assist in waterproofing purses. They take the form of a waterproof cover that is worn on a purse to protect it from rain. The purse rain cover is commonly made out of waterproof fabrics such as PEVA or polyester. Some retailers ... | milkshake721/2.1M-wiki-STEM |
Purse accessories-Purse organizer-These assist in organizing, and ease finding objects inside purses, especially when they are overloaded. The purse organizer is inserted into the purse, and typically, has several pockets that can be used to group different items into separate groups, for example, electronics, make-up,... | milkshake721/2.1M-wiki-STEM |
Purse accessories-Fur and charms-Fur or charms can be added to purses, either as attachments, or as cosmetic covers. | milkshake721/2.1M-wiki-STEM |
Conical pendulum-Conical pendulum-A conical pendulum consists of a weight (or bob) fixed on the end of a string or rod suspended from a pivot. Its construction is similar to an ordinary pendulum; however, instead of swinging back and forth along a circular arc, the bob of a conical pendulum moves at a constant speed in... | milkshake721/2.1M-wiki-STEM |
Conical pendulum-Uses-During the 1800s, conical pendulums were used as the timekeeping element in a few clockwork timing mechanisms where a smooth motion was required, as opposed to the unavoidably jerky motion provided by ordinary pendulums. Two examples were mechanisms to turn the lenses of lighthouses to sweep their... | milkshake721/2.1M-wiki-STEM |
Conical pendulum-Analysis-Consider a conical pendulum consisting of a bob of mass m revolving without friction in a circle at a constant speed v on a string of length L at an angle of θ from the vertical.
There are two forces acting on the bob: the tension T in the string, which is exerted along the line of the string ... | milkshake721/2.1M-wiki-STEM |
Conical pendulum-Analysis-the downward bob weight mg, where m is the mass of the bob and g is the local gravitational acceleration.The force exerted by the string can be resolved into a horizontal component, T sin(θ), toward the center of the circle, and a vertical component, T cos(θ), in the upward direction. From New... | milkshake721/2.1M-wiki-STEM |
JAM notation-JAM notation-JAM is both the software and file format for representing music as human-readable and human-writable text.
Unlike the ABC notation, another text-based music format, that is best suitable for one-voice tunes, JAM is mainly focused on chords. | milkshake721/2.1M-wiki-STEM |
JAM notation-JAM notation-Here is an example of jam notation: ### LULLABY OF BIRDLAND Dm7 Bm7-5 | E7 A7 | Dm7 / | Gm7 C7 F+7 F7 | Bb+7 Bbm7 | F+7 / | Em7-5 A7 Dm7 Bm7-5 | E7 A7 | Dm7 / | Gm7 C7 F+7 F7 | Bb+7 Bbm7 | F+7 C7 | F+7 / Am7-5 D7 | Gm7 / | Gm7-5 C7 | F+7 / Am7-5 D7 | Gm7 / | Gm7-5 C7 | F+7 A7 Dm7 Bm7-5 | E7 A7... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Venetoclax-Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or acute myeloid leukemia (AML).The most common side effects are low levels of neutrophils (a type of white blood cell), d... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Medical uses-CLL/SLL In the US, venetoclax is indicated for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Indication does not depend on mutation status (e. g. 17p deletion, IGHV mutation, 12+). | milkshake721/2.1M-wiki-STEM |
Venetoclax-Medical uses-In the EU, venetoclax monotherapy is indicated for the treatment of chronic lymphocytic leukaemia (CLL) in the presence of 17p deletion or TP53 mutation in adults who are unsuitable for or have failed a B cell receptor pathway inhibitor and for the treatment of CLL in the absence of 17p deletion... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Medical uses-Other types of leukemia Venetoclax is also indicated as part of a combination therapy for acute myeloid leukemia (AML). For this purpose it is used with azacitidine, decitabine, or low-dose cytarabine for newly diagnosed adults who are age 75 years or older, or those with other health problems w... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Side effects-Common side effects of venetoclax include neutropenia (low white blood cell count), nausea, anemia, diarrhea, upper respiratory tract infection, fatigue, and thrombocytopenia (low platelet count). Major side effects include tumor lysis syndrome and severe neutropenia. Additionally, this drug may... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Pharmacology-Mechanism of action Venetoclax is a BH3-mimetic. Venetoclax blocks the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein, leading to programmed cell death of CLL cells. Overexpression of Bcl-2 in some lymphoid malignancies has been linked to increased resistance to chemotherapy. | milkshake721/2.1M-wiki-STEM |
Venetoclax-Pharmacology-Pharmacokinetics The maximum plasma concentration achieved after oral administration occurred 5–8 hours after dose. Steady state maximum concentration with low-fat meal conditions at the 400 mg once daily dose was found to be 2.1 ± 1.1 μg/mL. It is recommended that venetoclax be administered wit... | milkshake721/2.1M-wiki-STEM |
Venetoclax-History-In 2015, the United States Food and Drug Administration (FDA) granted the breakthrough therapy designation to venetoclax for people with CLL or SLL who have relapsed, become intolerant to, or refractory to previous treatment.In April 2016, the FDA approved venetoclax for use in those with CLL who hav... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Society and culture-AbbVie Inc. manufactures Venclexta. It is marketed by both Abbvie and Genentech USA, which is a member of the Roche Group. AbbVie and Genentech are both commercializing the drug within the United States, but only AbbVie has rights to do so outside of the U.S.According to Reuters 2016 Drug... | milkshake721/2.1M-wiki-STEM |
Venetoclax-Research-As of 2016, venetoclax had been tested to treat other hematological cancers, including non-Hodgkin's lymphoma, multiple myeloma, diffuse large B-cell lymphoma and follicular lymphoma.: 7–8 On 13 June 2020 at the European Hematology Association (EHA) annual congress, AbbVie and Roche announced the re... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Donkey milk-Donkey milk (or ass milk, or jenny milk) is the milk from the domesticated donkey (Equus asinus). It has been used since antiquity for cosmetic purposes as well as infant nutrition. | milkshake721/2.1M-wiki-STEM |
Donkey milk-History-Donkey milk has been used by humans for alimentary and cosmetic purposes since Egyptian antiquity; doctors recommended it to treat several afflictions, due to its healing and cosmetic virtues.Hippocrates (460 – 370 BC), was the first to write of the medicinal use of donkey milk and prescribed it for... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Production-The donkey is considered a seasonal polyestrous one, but the latitude in which the farm is located can greatly influence the reproduction cycle. The female is normally pregnant for about 12 months.Donkey milk production differs greatly from that of conventional dairy species, especially in terms ... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Composition-Gross composition Published data on donkey milk gross composition confirm the closer resemblance to breast milk for lactose, protein and ash levels when compared with cow, sheep and goat milk. Despite the high lactose content of donkey milk the average fat content is lower for this purpose. When... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Composition-The casein to whey protein ratio in donkey milk was lower compared to the value on cow milk.
The non-protein nitrogen (NPN) accounts for an average of 16% of total nitrogen in donkey milk, is much closer than values reported for human milk (20%) but higher than those of domestic ruminants (5%).
... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Composition-Functional and bioactive components Among the functional proteins detected in donkey milk, there are molecules active in antimicrobial protection such as lysozyme and lactoferrin. The lactoferrin content of donkey milk is intermediate between the lower values of cow milk and the higher values of... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Nutritional use-Natural hypoallergenic milk for infants with cows’ milk protein allergy Pasteurized donkey milk is used as a natural hypoallergenic milk, because it is tolerated by about 90% of infants with food allergies, e.g., cows’ milk protein allergy (CMPA), a common food allergy in childhood with a pr... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Nutritional use-In terms of energy despite the high lactose content of donkey milk the average fat content is lower if used predominantly before weaning. | milkshake721/2.1M-wiki-STEM |
Donkey milk-Nutritional use-When used in infant nutrition before weaning, due to its low fat content to mimic breast milk, like all infant formulas, donkey milk should be integrated with a source of fat particular attention must also be given to essential fatty acids. Omega‐3 and omega‐6 fatty acids, particularly docos... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Nutritional use-From the point of view of hygienic-sanitary safety, like all milks, donkey milk and its ingredients must be pasteurized before taking; the process of pasteurizing donkey milk deactivates bacterial and viral contaminants.
Donkey milk contains immune-enhancing compounds (in particular lysozyme... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Commercial forms-Raw donkey milk Donkey milk milked and cooled to refrigeration temperature. According to European legislation, like all milks of animal origin, it must be pasteurized before being used, i.e. it must be cooked at home up to about 90 °C for at least 2 minutes.
Raw milk can be kept for 3 days ... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Commercial forms-Pasteurized donkey milk Donkey milk is pasteurized in a closed circuit of pasteurization and bottling (aseptic) at at least 72 °C for 15 seconds or equivalent times and temperatures. In case of pasteurization in discontinuous systems, the temperature must be higher depending on the method u... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Commercial forms-This product it is easy to find in Italy and Europa , where it was for the first time put on the market.
Fermented donkey milk (kumis) The use of fermented equid milk is an ancient tradition in central Asia, like kumis or airag, a fermented mares milk very popular in Asia and Russia; but th... | milkshake721/2.1M-wiki-STEM |
Donkey milk-Cosmetic use-Cosmetics with donkey milk In recent years, the cosmetic industry is mainly focused towards products made with natural ingredients and it is oriented to a sustainable consumption. Because of their natural origin, milk components correspond in many fields to the needs of cosmetology.Recent scien... | milkshake721/2.1M-wiki-STEM |
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