id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_hall_00063 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ABCA7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BIN1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABCA7",
"source_node_type": "GENE",
"source_node_label": "ABCA7",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.824,
"edge_source_db": "STRING",
... | D | [
"A. SOX2 interacts with CHPF",
"B. ABCA7 interacts with BIN1",
"C. BRCA2 interacts with TTI1",
"D. FGA interacts with DHX33"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABCA7",
"source_db": "UniProt",
"payload": {
"accession": "Q8IZY2",
"sequence": "MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLR... | [
{
"source_db": "STRING",
"source_id": "BIN1",
"text": "ABCA7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BIN1",
"confidence": 0.824
}
] | {
"mode": "interaction",
"fabricated": "FGA interacts with DHX33",
"real_options": [
"ABCA7 interacts with BIN1",
"BRCA2 interacts with TTI1",
"SOX2 interacts with CHPF"
]
} | 0.824 |
co_hall_00064 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CHEK2 GENE_ENCODES_PROTEIN CHEK2 -> CHEK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPM1D -> PPM1D GENE_ENCODES_PROTEIN PPM1D | {
"steps": [
{
"hop": 1,
"source_node_id": "CHEK2",
"source_node_type": "GENE",
"source_node_label": "CHEK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1120... | A | [
"A. ACP4 interacts with CDCA2",
"B. C9orf72 interacts with SEH1L",
"C. C9orf72 interacts with CDK1",
"D. CHEK2 interacts with PPM1D"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CHEK2",
"source_db": "UniProt",
"payload": {
"accession": "O96017",
"sequence": "MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRT... | [
{
"source_db": "bridge",
"source_id": "11200",
"text": "CHEK2 GENE_ENCODES_PROTEIN CHEK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8493",
"text": "CHEK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPM1D",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "ACP4 interacts with CDCA2",
"real_options": [
"CHEK2 interacts with PPM1D",
"C9orf72 interacts with CDK1",
"C9orf72 interacts with SEH1L"
]
} | 0.9 |
co_hall_00065 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH HTT -> HTT GENE_ENCODES_PROTEIN HTT | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | D | [
"A. RIPK2 interacts with SQSTM1",
"B. ASXL1 interacts with EEF1B2",
"C. VCP interacts with HTT",
"D. ARHGEF12 interacts with ITIH2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3064",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH HTT",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "H... | {
"mode": "interaction",
"fabricated": "ARHGEF12 interacts with ITIH2",
"real_options": [
"VCP interacts with HTT",
"ASXL1 interacts with EEF1B2",
"RIPK2 interacts with SQSTM1"
]
} | 0.9 |
co_hall_00066 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TIA1 GENE_ENCODES_PROTEIN TIA1 -> TIA1 PROTEIN_PHYSICALLY_INTERACTS_WITH TOP3B -> TOP3B GENE_ENCODES_PROTEIN TOP3B | {
"steps": [
{
"hop": 1,
"source_node_id": "TIA1",
"source_node_type": "GENE",
"source_node_label": "TIA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7072",... | C | [
"A. FYN interacts with CDH1",
"B. SERBP1 interacts with MAPK1",
"C. Presenilin-2 interacts with UBB_UBE2J1",
"D. TIA1 interacts with TOP3B"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TIA1",
"source_db": "UniProt",
"payload": {
"accession": "P31483",
"sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISD... | [
{
"source_db": "bridge",
"source_id": "7072",
"text": "TIA1 GENE_ENCODES_PROTEIN TIA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8940",
"text": "TIA1 PROTEIN_PHYSICALLY_INTERACTS_WITH TOP3B",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "Presenilin-2 interacts with UBB_UBE2J1",
"real_options": [
"TIA1 interacts with TOP3B",
"SERBP1 interacts with MAPK1",
"FYN interacts with CDH1"
]
} | 0.9 |
co_hall_00067 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TFAP2B GENE_ENCODES_PROTEIN TFAP2B -> TFAP2B PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP -> CREBBP GENE_ENCODES_PROTEIN CREBBP | {
"steps": [
{
"hop": 1,
"source_node_id": "TFAP2B",
"source_node_type": "GENE",
"source_node_label": "TFAP2B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "70... | B | [
"A. TFAP2B interacts with CREBBP",
"B. ENSP00000599314 interacts with PHF12",
"C. UBQLN2 interacts with PSMD4",
"D. SRRM1 interacts with KMT2D"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "7021",
"text": "TFAP2B GENE_ENCODES_PROTEIN TFAP2B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1387",
"text": "TFAP2B PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "ENSP00000599314 interacts with PHF12",
"real_options": [
"TFAP2B interacts with CREBBP",
"SRRM1 interacts with KMT2D",
"UBQLN2 interacts with PSMD4"
]
} | 0.9 |
co_hall_00068 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AP2B1 GENE_ENCODES_PROTEIN AP2B1 -> AP2B1 PROTEIN_PHYSICALLY_INTERACTS_WITH BUB1B -> BUB1B GENE_ENCODES_PROTEIN BUB1B | {
"steps": [
{
"hop": 1,
"source_node_id": "AP2B1",
"source_node_type": "GENE",
"source_node_label": "AP2B1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "163"... | D | [
"A. ERBB4 interacts with HBEGF",
"B. AP2B1 interacts with BUB1B",
"C. CHEK2 interacts with IL24",
"D. ENSP00000522425 interacts with TRIM44"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BUB1B",
"source_db": "UniProt",
"payload": {
"accession": "O60566",
"sequence": "MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCN... | [
{
"source_db": "bridge",
"source_id": "163",
"text": "AP2B1 GENE_ENCODES_PROTEIN AP2B1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "701",
"text": "AP2B1 PROTEIN_PHYSICALLY_INTERACTS_WITH BUB1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000522425 interacts with TRIM44",
"real_options": [
"AP2B1 interacts with BUB1B",
"ERBB4 interacts with HBEGF",
"CHEK2 interacts with IL24"
]
} | 0.9 |
co_hall_00069 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2 -> HDAC2 GENE_ENCODES_PROTEIN HDAC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | D | [
"A. C9orf72 interacts with SNRPC",
"B. C9orf72 interacts with KPNA3",
"C. AR interacts with HDAC2",
"D. CBR1 interacts with IRS1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3066",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "HDA... | {
"mode": "interaction",
"fabricated": "CBR1 interacts with IRS1",
"real_options": [
"AR interacts with HDAC2",
"C9orf72 interacts with SNRPC",
"C9orf72 interacts with KPNA3"
]
} | 0.9 |
co_hall_00070 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EHMT2 GENE_ENCODES_PROTEIN EHMT2 -> EHMT2 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "EHMT2",
"source_node_type": "PROTEIN",
"source_node_label": "EHMT2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1... | C | [
"A. VCP interacts with RAD50",
"B. RPS6KA3 interacts with CREBBP",
"C. ENSP00000606568 interacts with LINC01485",
"D. EHMT2 interacts with TP53"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "10919",
"text": "EHMT2 GENE_ENCODES_PROTEIN EHMT2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "EHMT2 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "ENSP00000606568 interacts with LINC01485",
"real_options": [
"EHMT2 interacts with TP53",
"RPS6KA3 interacts with CREBBP",
"VCP interacts with RAD50"
]
} | 0.9 |
co_hall_00071 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MORF4L2 GENE_ENCODES_PROTEIN MORF4L2 -> MORF4L2 PROTEIN_PHYSICALLY_INTERACTS_WITH PALB2 -> PALB2 GENE_ENCODES_PROTEIN PALB2 | {
"steps": [
{
"hop": 1,
"source_node_id": "MORF4L2",
"source_node_type": "PROTEIN",
"source_node_label": "MORF4L2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id"... | D | [
"A. ALK interacts with PIK3CA",
"B. MORF4L2 interacts with PALB2",
"C. SQSTM1 interacts with CASP1",
"D. ENSP00000659441 interacts with JAK1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PALB2",
"source_db": "UniProt",
"payload": {
"accession": "Q86YC2",
"sequence": "MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQQDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQRTDDTQEHFPHRVS... | [
{
"source_db": "bridge",
"source_id": "9643",
"text": "MORF4L2 GENE_ENCODES_PROTEIN MORF4L2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "79728",
"text": "MORF4L2 PROTEIN_PHYSICALLY_INTERACTS_WITH PALB2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000659441 interacts with JAK1",
"real_options": [
"MORF4L2 interacts with PALB2",
"SQSTM1 interacts with CASP1",
"ALK interacts with PIK3CA"
]
} | 0.9 |
co_hall_00072 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH NFYB -> NFYB GENE_ENCODES_PROTEIN NFYB | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | A | [
"A. STOML2 interacts with ENSP00000354838",
"B. BRCA1 interacts with RDX",
"C. CREBBP interacts with NFYB",
"D. TP53 interacts with KAT6A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4801",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH NFYB",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "STOML2 interacts with ENSP00000354838",
"real_options": [
"CREBBP interacts with NFYB",
"BRCA1 interacts with RDX",
"TP53 interacts with KAT6A"
]
} | 0.9 |
co_hall_00073 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SCD GENE_ENCODES_PROTEIN SCD -> SCD PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "SCD",
"source_node_type": "GENE",
"source_node_label": "SCD",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6319",
... | D | [
"A. TARDBP interacts with TARDBP",
"B. SCD interacts with VCP",
"C. RAD50 interacts with ATM",
"D. FBXO32 interacts with NKAIN4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "6319",
"text": "SCD GENE_ENCODES_PROTEIN SCD",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "SCD PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "V... | {
"mode": "interaction",
"fabricated": "FBXO32 interacts with NKAIN4",
"real_options": [
"SCD interacts with VCP",
"RAD50 interacts with ATM",
"TARDBP interacts with TARDBP"
]
} | 0.9 |
co_hall_00074 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH ANKRD13D -> ANKRD13D GENE_ENCODES_PROTEIN ANKRD13D | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | B | [
"A. SQSTM1 interacts with NOTCH1",
"B. TNFRSF1A interacts with SOX14",
"C. NUDCD1 interacts with ERBB4",
"D. EGFR interacts with ANKRD13D"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "338692",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH ANKRD13D",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "TNFRSF1A interacts with SOX14",
"real_options": [
"EGFR interacts with ANKRD13D",
"NUDCD1 interacts with ERBB4",
"SQSTM1 interacts with NOTCH1"
]
} | 0.9 |
co_hall_00075 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | UBD GENE_ENCODES_PROTEIN UBD -> UBD PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6 -> PSMA6 GENE_ENCODES_PROTEIN PSMA6 | {
"steps": [
{
"hop": 1,
"source_node_id": "UBD",
"source_node_type": "GENE",
"source_node_label": "UBD",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10537",
... | D | [
"A. EGFR interacts with ICAM1",
"B. UBD interacts with PSMA6",
"C. SOX2 interacts with DNAJB3",
"D. FMNL1 interacts with POLQ"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSMA6",
"source_db": "UniProt",
"payload": {
"accession": "P60900",
"sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRP... | [
{
"source_db": "bridge",
"source_id": "10537",
"text": "UBD GENE_ENCODES_PROTEIN UBD",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5687",
"text": "UBD PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "FMNL1 interacts with POLQ",
"real_options": [
"UBD interacts with PSMA6",
"SOX2 interacts with DNAJB3",
"EGFR interacts with ICAM1"
]
} | 0.9 |
co_hall_00076 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PHGDH GENE_ENCODES_PROTEIN PHGDH -> PHGDH PROTEIN_PHYSICALLY_INTERACTS_WITH SNCA -> SNCA GENE_ENCODES_PROTEIN SNCA | {
"steps": [
{
"hop": 1,
"source_node_id": "PHGDH",
"source_node_type": "GENE",
"source_node_label": "PHGDH",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2622... | C | [
"A. PHGDH interacts with SNCA",
"B. PTEN interacts with WNT4",
"C. GALK1 interacts with NRG3",
"D. AR interacts with PIAS2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SNCA",
"source_db": "UniProt",
"payload": {
"accession": "P37840",
"sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQ... | [
{
"source_db": "bridge",
"source_id": "26227",
"text": "PHGDH GENE_ENCODES_PROTEIN PHGDH",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6622",
"text": "PHGDH PROTEIN_PHYSICALLY_INTERACTS_WITH SNCA",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "GALK1 interacts with NRG3",
"real_options": [
"PHGDH interacts with SNCA",
"AR interacts with PIAS2",
"PTEN interacts with WNT4"
]
} | 0.9 |
co_hall_00077 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VHL GENE_ENCODES_PROTEIN VHL -> VHL PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN1A -> CDKN1A GENE_ENCODES_PROTEIN CDKN1A | {
"steps": [
{
"hop": 1,
"source_node_id": "VHL",
"source_node_type": "PROTEIN",
"source_node_label": "VHL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7428"... | A | [
"A. CDH5 interacts with RNF13",
"B. VHL interacts with CDKN1A",
"C. CDC37 interacts with CDK1",
"D. CDK1 interacts with TSC1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN1A",
"source_db": "UniProt",
"payload": {
"accession": "P38936",
"sequence": "MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPG... | [
{
"source_db": "bridge",
"source_id": "7428",
"text": "VHL GENE_ENCODES_PROTEIN VHL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1026",
"text": "VHL PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN1A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "CDH5 interacts with RNF13",
"real_options": [
"VHL interacts with CDKN1A",
"CDC37 interacts with CDK1",
"CDK1 interacts with TSC1"
]
} | 0.9 |
co_hall_00078 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CD4 GENE_ENCODES_PROTEIN CD4 -> CD4 PROTEIN_PHYSICALLY_INTERACTS_WITH ZAP70 -> ZAP70 GENE_ENCODES_PROTEIN ZAP70 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD4",
"source_node_type": "GENE",
"source_node_label": "CD4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "920",
... | D | [
"A. CD4 interacts with ZAP70",
"B. ASXL1 interacts with PKM",
"C. HIST2H3C interacts with BIRC5",
"D. UBE2E1 interacts with ENSP00000410838"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD4",
"source_db": "UniProt",
"payload": {
"accession": "P01730",
"sequence": "MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQ... | [
{
"source_db": "bridge",
"source_id": "920",
"text": "CD4 GENE_ENCODES_PROTEIN CD4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7535",
"text": "CD4 PROTEIN_PHYSICALLY_INTERACTS_WITH ZAP70",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"mode": "interaction",
"fabricated": "UBE2E1 interacts with ENSP00000410838",
"real_options": [
"CD4 interacts with ZAP70",
"HIST2H3C interacts with BIRC5",
"ASXL1 interacts with PKM"
]
} | 0.9 |
co_hall_00079 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BRCA2 GENE_ENCODES_PROTEIN BRCA2 -> BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2 -> BCL2 GENE_ENCODES_PROTEIN BCL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA2",
"source_node_type": "GENE",
"source_node_label": "BRCA2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "675"... | D | [
"A. BRCA2 interacts with BCL2",
"B. PTEN interacts with PIK3R1",
"C. DYNLT1 interacts with SOD1",
"D. Parkinson disease protein 7 interacts with BRMS1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "675",
"text": "BRCA2 GENE_ENCODES_PROTEIN BRCA2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "596",
"text": "BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "Parkinson disease protein 7 interacts with BRMS1",
"real_options": [
"BRCA2 interacts with BCL2",
"DYNLT1 interacts with SOD1",
"PTEN interacts with PIK3R1"
]
} | 0.9 |
co_hall_00080 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CASP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH XIAP | {
"steps": [
{
"hop": 1,
"source_node_id": "CASP3",
"source_node_type": "GENE",
"source_node_label": "CASP3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000783676 interacts with XDH",
"B. CASP3 interacts with XIAP",
"C. TCERG1 interacts with HTT",
"D. CDH1 interacts with KEAP1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP3",
"source_db": "UniProt",
"payload": {
"accession": "P42574",
"sequence": "MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP... | [
{
"source_db": "STRING",
"source_id": "XIAP",
"text": "CASP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH XIAP",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000783676 interacts with XDH",
"real_options": [
"CASP3 interacts with XIAP",
"TCERG1 interacts with HTT",
"CDH1 interacts with KEAP1"
]
} | 0.999 |
co_hall_00081 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | YWHAQ GENE_ENCODES_PROTEIN YWHAQ -> YWHAQ PROTEIN_PHYSICALLY_INTERACTS_WITH LRRK2 -> LRRK2 GENE_ENCODES_PROTEIN LRRK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "YWHAQ",
"source_node_type": "PROTEIN",
"source_node_label": "YWHAQ",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1... | D | [
"A. MET interacts with MYO18A",
"B. YWHAQ interacts with LRRK2",
"C. NLRP3 interacts with FBXL2",
"D. INHBB interacts with LIG1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "bridge",
"source_id": "10971",
"text": "YWHAQ GENE_ENCODES_PROTEIN YWHAQ",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "120892",
"text": "YWHAQ PROTEIN_PHYSICALLY_INTERACTS_WITH LRRK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "INHBB interacts with LIG1",
"real_options": [
"YWHAQ interacts with LRRK2",
"NLRP3 interacts with FBXL2",
"MET interacts with MYO18A"
]
} | 0.9 |
co_hall_00082 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CBL GENE_ENCODES_PROTEIN CBL -> CBL PROTEIN_PHYSICALLY_INTERACTS_WITH TFRC -> TFRC GENE_ENCODES_PROTEIN TFRC | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "867",
... | B | [
"A. CBL interacts with TFRC",
"B. SNIP1 interacts with ENSP00000605905",
"C. SPOP interacts with RPS16",
"D. SOX2 interacts with PSMB3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "867",
"text": "CBL GENE_ENCODES_PROTEIN CBL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7037",
"text": "CBL PROTEIN_PHYSICALLY_INTERACTS_WITH TFRC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "T... | {
"mode": "interaction",
"fabricated": "SNIP1 interacts with ENSP00000605905",
"real_options": [
"CBL interacts with TFRC",
"SOX2 interacts with PSMB3",
"SPOP interacts with RPS16"
]
} | 0.9 |
co_hall_00083 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH DNAJC13 -> DNAJC13 GENE_ENCODES_PROTEIN DNAJC13 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | B | [
"A. ERBB2 interacts with ERBB3",
"B. TSSC1 interacts with IRF2BP2",
"C. PKD2 interacts with AKT1",
"D. SOX2 interacts with DNAJC13"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "23317",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH DNAJC13",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "TSSC1 interacts with IRF2BP2",
"real_options": [
"SOX2 interacts with DNAJC13",
"PKD2 interacts with AKT1",
"ERBB2 interacts with ERBB3"
]
} | 0.9 |
co_hall_00084 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PARK7 GENE_ENCODES_PROTEIN PARK7 -> PARK7 PROTEIN_PHYSICALLY_INTERACTS_WITH ITPR3 -> ITPR3 GENE_ENCODES_PROTEIN ITPR3 | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK7",
"source_node_type": "GENE",
"source_node_label": "PARK7",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1131... | A | [
"A. ENSP00000526473 interacts with ONECUT1",
"B. TP53 interacts with DDX20",
"C. PARK7 interacts with ITPR3",
"D. SQSTM1 interacts with SESN2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PARK7",
"source_db": "UniProt",
"payload": {
"accession": "Q99497",
"sequence": "MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKM... | [
{
"source_db": "bridge",
"source_id": "11315",
"text": "PARK7 GENE_ENCODES_PROTEIN PARK7",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3710",
"text": "PARK7 PROTEIN_PHYSICALLY_INTERACTS_WITH ITPR3",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "ENSP00000526473 interacts with ONECUT1",
"real_options": [
"PARK7 interacts with ITPR3",
"TP53 interacts with DDX20",
"SQSTM1 interacts with SESN2"
]
} | 0.9 |
co_hall_00085 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BUB3 GENE_ENCODES_PROTEIN BUB3 -> BUB3 PROTEIN_PHYSICALLY_INTERACTS_WITH APC -> APC GENE_ENCODES_PROTEIN APC | {
"steps": [
{
"hop": 1,
"source_node_id": "BUB3",
"source_node_type": "GENE",
"source_node_label": "BUB3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9184",... | C | [
"A. PCGF3 interacts with BCOR",
"B. ERBB2 interacts with PTPN11",
"C. ENSP00000482768 interacts with E2F1",
"D. BUB3 interacts with APC"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APC",
"source_db": "UniProt",
"payload": {
"accession": "P25054",
"sequence": "MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLE... | [
{
"source_db": "bridge",
"source_id": "9184",
"text": "BUB3 GENE_ENCODES_PROTEIN BUB3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "324",
"text": "BUB3 PROTEIN_PHYSICALLY_INTERACTS_WITH APC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "ENSP00000482768 interacts with E2F1",
"real_options": [
"BUB3 interacts with APC",
"PCGF3 interacts with BCOR",
"ERBB2 interacts with PTPN11"
]
} | 0.9 |
co_hall_00086 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AXIN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GSK3B | {
"steps": [
{
"hop": 1,
"source_node_id": "AXIN2",
"source_node_type": "GENE",
"source_node_label": "AXIN2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000595862 interacts with UBB_UBE2J2",
"B. AXIN2 interacts with GSK3B",
"C. ATP13A2 interacts with BNIP3L",
"D. TNFRSF11A interacts with EGFR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AXIN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y2T1",
"sequence": "MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKA... | [
{
"source_db": "STRING",
"source_id": "GSK3B",
"text": "AXIN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GSK3B",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000595862 interacts with UBB_UBE2J2",
"real_options": [
"AXIN2 interacts with GSK3B",
"ATP13A2 interacts with BNIP3L",
"TNFRSF11A interacts with EGFR"
]
} | 0.999 |
co_hall_00087 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | IFIH1 GENE_ENCODES_PROTEIN IFIH1 -> IFIH1 PROTEIN_PHYSICALLY_INTERACTS_WITH SQSTM1 -> SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 | {
"steps": [
{
"hop": 1,
"source_node_id": "IFIH1",
"source_node_type": "GENE",
"source_node_label": "IFIH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6413... | D | [
"A. IFIH1 interacts with SQSTM1",
"B. FOXP2 interacts with TP53",
"C. C9orf72 interacts with LDHB",
"D. TMEM129 interacts with PRKDC"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "64135",
"text": "IFIH1 GENE_ENCODES_PROTEIN IFIH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8878",
"text": "IFIH1 PROTEIN_PHYSICALLY_INTERACTS_WITH SQSTM1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "TMEM129 interacts with PRKDC",
"real_options": [
"IFIH1 interacts with SQSTM1",
"FOXP2 interacts with TP53",
"C9orf72 interacts with LDHB"
]
} | 0.9 |
co_hall_00088 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH STAT2 -> STAT2 GENE_ENCODES_PROTEIN STAT2 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | C | [
"A. SOD1 interacts with CCS",
"B. LRRK2 interacts with MAPT",
"C. MUL1 interacts with NR4A2",
"D. EGFR interacts with STAT2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6773",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH STAT2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "MUL1 interacts with NR4A2",
"real_options": [
"EGFR interacts with STAT2",
"SOD1 interacts with CCS",
"LRRK2 interacts with MAPT"
]
} | 0.9 |
co_hall_00089 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ATM GENE_ENCODES_PROTEIN ATM -> ATM PROTEIN_PHYSICALLY_INTERACTS_WITH MAGEC2 -> MAGEC2 GENE_ENCODES_PROTEIN MAGEC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATM",
"source_node_type": "GENE",
"source_node_label": "ATM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "472",
... | B | [
"A. YWHAG interacts with APP",
"B. ABCG1 interacts with CALM1",
"C. EGFR interacts with SMC2",
"D. ATM interacts with MAGEC2"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATM",
"source_db": "UniProt",
"payload": {
"accession": "Q13315",
"sequence": "MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGA... | [
{
"source_db": "bridge",
"source_id": "472",
"text": "ATM GENE_ENCODES_PROTEIN ATM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "51438",
"text": "ATM PROTEIN_PHYSICALLY_INTERACTS_WITH MAGEC2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "ABCG1 interacts with CALM1",
"real_options": [
"ATM interacts with MAGEC2",
"EGFR interacts with SMC2",
"YWHAG interacts with APP"
]
} | 0.9 |
co_hall_00090 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ALK GENE_ENCODES_PROTEIN ALK -> ALK PROTEIN_PHYSICALLY_INTERACTS_WITH RAD17 -> RAD17 GENE_ENCODES_PROTEIN RAD17 | {
"steps": [
{
"hop": 1,
"source_node_id": "ALK",
"source_node_type": "GENE",
"source_node_label": "ALK",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "238",
... | B | [
"A. JAK2 interacts with GTF2I",
"B. TANK interacts with ESR2",
"C. DUSP1 interacts with MAPT",
"D. ALK interacts with RAD17"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ALK",
"source_db": "UniProt",
"payload": {
"accession": "Q9UM73",
"sequence": "MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKL... | [
{
"source_db": "bridge",
"source_id": "238",
"text": "ALK GENE_ENCODES_PROTEIN ALK",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5884",
"text": "ALK PROTEIN_PHYSICALLY_INTERACTS_WITH RAD17",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"mode": "interaction",
"fabricated": "TANK interacts with ESR2",
"real_options": [
"ALK interacts with RAD17",
"DUSP1 interacts with MAPT",
"JAK2 interacts with GTF2I"
]
} | 0.9 |
co_hall_00091 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | DAB2IP GENE_ENCODES_PROTEIN DAB2IP -> DAB2IP PROTEIN_PHYSICALLY_INTERACTS_WITH BUB1B -> BUB1B GENE_ENCODES_PROTEIN BUB1B | {
"steps": [
{
"hop": 1,
"source_node_id": "DAB2IP",
"source_node_type": "GENE",
"source_node_label": "DAB2IP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "15... | D | [
"A. MAPT interacts with EPB41",
"B. DAB2IP interacts with BUB1B",
"C. SH2B3 interacts with JAK2",
"D. IKBIP interacts with ENSP00000610005"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BUB1B",
"source_db": "UniProt",
"payload": {
"accession": "O60566",
"sequence": "MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCN... | [
{
"source_db": "bridge",
"source_id": "153090",
"text": "DAB2IP GENE_ENCODES_PROTEIN DAB2IP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "701",
"text": "DAB2IP PROTEIN_PHYSICALLY_INTERACTS_WITH BUB1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "IKBIP interacts with ENSP00000610005",
"real_options": [
"DAB2IP interacts with BUB1B",
"SH2B3 interacts with JAK2",
"MAPT interacts with EPB41"
]
} | 0.9 |
co_hall_00092 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ECT2 -> ECT2 GENE_ENCODES_PROTEIN ECT2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | A | [
"A. SHANK3 interacts with GSTO1",
"B. C9orf72 interacts with ECT2",
"C. CD44 interacts with STAT3",
"D. PDGFRB interacts with ABL1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1894",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ECT2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "SHANK3 interacts with GSTO1",
"real_options": [
"C9orf72 interacts with ECT2",
"CD44 interacts with STAT3",
"PDGFRB interacts with ABL1"
]
} | 0.9 |
co_hall_00093 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 -> CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH MEN1 -> MEN1 GENE_ENCODES_PROTEIN MEN1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | D | [
"A. CTNNB1 interacts with MEN1",
"B. BRCA2 interacts with DNMT1",
"C. ORC2 interacts with BRCA1",
"D. ENSP00000482559 interacts with ENSP00000463427"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "1499",
"text": "CTNNB1 GENE_ENCODES_PROTEIN CTNNB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4221",
"text": "CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH MEN1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000482559 interacts with ENSP00000463427",
"real_options": [
"CTNNB1 interacts with MEN1",
"BRCA2 interacts with DNMT1",
"ORC2 interacts with BRCA1"
]
} | 0.9 |
co_hall_00094 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | RAD51C PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH XRCC3 | {
"steps": [
{
"hop": 1,
"source_node_id": "RAD51C",
"source_node_type": "GENE",
"source_node_label": "RAD51C",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000548446 interacts with EYA1",
"B. PPP2R4 interacts with CTNNB1",
"C. ATXN3 interacts with VCP",
"D. RAD51C interacts with XRCC3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RAD51C",
"source_db": "UniProt",
"payload": {
"accession": "O43502",
"sequence": "MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKT... | [
{
"source_db": "STRING",
"source_id": "XRCC3",
"text": "RAD51C PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH XRCC3",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000548446 interacts with EYA1",
"real_options": [
"RAD51C interacts with XRCC3",
"ATXN3 interacts with VCP",
"PPP2R4 interacts with CTNNB1"
]
} | 0.999 |
co_hall_00095 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | WWP2 GENE_ENCODES_PROTEIN WWP2 -> WWP2 PROTEIN_PHYSICALLY_INTERACTS_WITH BRAF -> BRAF GENE_ENCODES_PROTEIN BRAF | {
"steps": [
{
"hop": 1,
"source_node_id": "WWP2",
"source_node_type": "PROTEIN",
"source_node_label": "WWP2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "110... | C | [
"A. C9orf72 interacts with TSPYL1",
"B. WWP2 interacts with BRAF",
"C. ENSP00000474097 interacts with ENSP00000714605",
"D. AFP interacts with CASP3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRAF",
"source_db": "UniProt",
"payload": {
"accession": "P15056",
"sequence": "MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSS... | [
{
"source_db": "bridge",
"source_id": "11060",
"text": "WWP2 GENE_ENCODES_PROTEIN WWP2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "673",
"text": "WWP2 PROTEIN_PHYSICALLY_INTERACTS_WITH BRAF",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "ENSP00000474097 interacts with ENSP00000714605",
"real_options": [
"WWP2 interacts with BRAF",
"AFP interacts with CASP3",
"C9orf72 interacts with TSPYL1"
]
} | 0.9 |
co_hall_00096 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ANKRD13A GENE_ENCODES_PROTEIN ANKRD13A -> ANKRD13A PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "ANKRD13A",
"source_node_type": "GENE",
"source_node_label": "ANKRD13A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | B | [
"A. ANKRD13A interacts with VCP",
"B. ENSP00000792308 interacts with SOX8",
"C. SOX2 interacts with CCT6A",
"D. MYC interacts with CDK2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "88455",
"text": "ANKRD13A GENE_ENCODES_PROTEIN ANKRD13A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "ANKRD13A PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000792308 interacts with SOX8",
"real_options": [
"ANKRD13A interacts with VCP",
"SOX2 interacts with CCT6A",
"MYC interacts with CDK2"
]
} | 0.9 |
co_hall_00097 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BAP1 GENE_ENCODES_PROTEIN BAP1 -> BAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN -> PTEN GENE_ENCODES_PROTEIN PTEN | {
"steps": [
{
"hop": 1,
"source_node_id": "BAP1",
"source_node_type": "PROTEIN",
"source_node_label": "BAP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "831... | D | [
"A. AURKB interacts with USP29",
"B. PTEN interacts with UBC",
"C. BAP1 interacts with PTEN",
"D. DES interacts with SMARCA5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "bridge",
"source_id": "8314",
"text": "BAP1 GENE_ENCODES_PROTEIN BAP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5728",
"text": "BAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "DES interacts with SMARCA5",
"real_options": [
"BAP1 interacts with PTEN",
"PTEN interacts with UBC",
"AURKB interacts with USP29"
]
} | 0.9 |
co_hall_00098 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DOK7 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACHE",
"source_node_type": "GENE",
"source_node_label": "ACHE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.867,
"edge_source_db": "STRING",
"t... | C | [
"A. OPTN interacts with TRADD",
"B. ACHE interacts with DOK7",
"C. RFNG interacts with SLC6A2",
"D. C9orf72 interacts with SLC25A21"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACHE",
"source_db": "UniProt",
"payload": {
"accession": "P22303",
"sequence": "MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWT... | [
{
"source_db": "STRING",
"source_id": "DOK7",
"text": "ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DOK7",
"confidence": 0.867
}
] | {
"mode": "interaction",
"fabricated": "RFNG interacts with SLC6A2",
"real_options": [
"ACHE interacts with DOK7",
"OPTN interacts with TRADD",
"C9orf72 interacts with SLC25A21"
]
} | 0.867 |
co_hall_00099 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH ROBO2 -> ROBO2 GENE_ENCODES_PROTEIN ROBO2 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | A | [
"A. IMP3 interacts with ENSP00000472600",
"B. MYC interacts with ROBO2",
"C. TCL1A interacts with ATM",
"D. SMARCD3 interacts with RXRA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6092",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH ROBO2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "IMP3 interacts with ENSP00000472600",
"real_options": [
"MYC interacts with ROBO2",
"TCL1A interacts with ATM",
"SMARCD3 interacts with RXRA"
]
} | 0.9 |
co_hall_00100 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH KRT10 -> KRT10 GENE_ENCODES_PROTEIN KRT10 | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | A | [
"A. JAK3 interacts with ENSP00000527998",
"B. DOT1L interacts with TARDBP",
"C. CBL interacts with PRDX4",
"D. VCP interacts with KRT10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3858",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH KRT10",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "JAK3 interacts with ENSP00000527998",
"real_options": [
"VCP interacts with KRT10",
"DOT1L interacts with TARDBP",
"CBL interacts with PRDX4"
]
} | 0.9 |
co_hall_00101 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH MON2 -> MON2 GENE_ENCODES_PROTEIN MON2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. CHEK2 interacts with FBXO22",
"B. C9orf72 interacts with MON2",
"C. HEXIM1 interacts with XRN1",
"D. MAVS interacts with ABL1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "23041",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH MON2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "HEXIM1 interacts with XRN1",
"real_options": [
"C9orf72 interacts with MON2",
"CHEK2 interacts with FBXO22",
"MAVS interacts with ABL1"
]
} | 0.9 |
co_hall_00102 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | RPL22L1 GENE_ENCODES_PROTEIN RPL22L1 -> RPL22L1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1 -> MAPK1 GENE_ENCODES_PROTEIN MAPK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "RPL22L1",
"source_node_type": "GENE",
"source_node_label": "RPL22L1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. RPL22L1 interacts with MAPK1",
"B. ERBB4 interacts with WWOX",
"C. YWHAE interacts with ENSP00000722002",
"D. PPP2R2A interacts with TUBA4A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "bridge",
"source_id": "200916",
"text": "RPL22L1 GENE_ENCODES_PROTEIN RPL22L1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5594",
"text": "RPL22L1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "YWHAE interacts with ENSP00000722002",
"real_options": [
"RPL22L1 interacts with MAPK1",
"ERBB4 interacts with WWOX",
"PPP2R2A interacts with TUBA4A"
]
} | 0.9 |
co_hall_00103 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ABCB1 GENE_ENCODES_PROTEIN ABCB1 -> ABCB1 PROTEIN_PHYSICALLY_INTERACTS_WITH CD44 -> CD44 GENE_ENCODES_PROTEIN CD44 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABCB1",
"source_node_type": "GENE",
"source_node_label": "ABCB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5243... | B | [
"A. BECN1 interacts with BCL2",
"B. ENSP00000570987 interacts with RBP1",
"C. CBL interacts with TLE3",
"D. ABCB1 interacts with CD44"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD44",
"source_db": "UniProt",
"payload": {
"accession": "P16070",
"sequence": "MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTD... | [
{
"source_db": "bridge",
"source_id": "5243",
"text": "ABCB1 GENE_ENCODES_PROTEIN ABCB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "960",
"text": "ABCB1 PROTEIN_PHYSICALLY_INTERACTS_WITH CD44",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000570987 interacts with RBP1",
"real_options": [
"ABCB1 interacts with CD44",
"BECN1 interacts with BCL2",
"CBL interacts with TLE3"
]
} | 0.9 |
co_hall_00104 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PDCD4 GENE_ENCODES_PROTEIN PDCD4 -> PDCD4 PROTEIN_PHYSICALLY_INTERACTS_WITH SQSTM1 -> SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 | {
"steps": [
{
"hop": 1,
"source_node_id": "PDCD4",
"source_node_type": "GENE",
"source_node_label": "PDCD4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2725... | D | [
"A. PDCD4 interacts with SQSTM1",
"B. DYNC1LI2 interacts with DCTN1",
"C. SPOP interacts with NDUFA12",
"D. ENSP00000429457 interacts with CPAP"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "27250",
"text": "PDCD4 GENE_ENCODES_PROTEIN PDCD4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8878",
"text": "PDCD4 PROTEIN_PHYSICALLY_INTERACTS_WITH SQSTM1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000429457 interacts with CPAP",
"real_options": [
"PDCD4 interacts with SQSTM1",
"SPOP interacts with NDUFA12",
"DYNC1LI2 interacts with DCTN1"
]
} | 0.9 |
co_hall_00105 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SH3KBP1 GENE_ENCODES_PROTEIN SH3KBP1 -> SH3KBP1 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR -> EGFR GENE_ENCODES_PROTEIN EGFR | {
"steps": [
{
"hop": 1,
"source_node_id": "SH3KBP1",
"source_node_type": "PROTEIN",
"source_node_label": "SH3KBP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id"... | B | [
"A. SH3KBP1 interacts with EGFR",
"B. MPDU1 interacts with ENSP00000788559",
"C. ESR1 interacts with UBE3A",
"D. SPOP interacts with PDCD6IP"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "30011",
"text": "SH3KBP1 GENE_ENCODES_PROTEIN SH3KBP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1956",
"text": "SH3KBP1 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"mode": "interaction",
"fabricated": "MPDU1 interacts with ENSP00000788559",
"real_options": [
"SH3KBP1 interacts with EGFR",
"SPOP interacts with PDCD6IP",
"ESR1 interacts with UBE3A"
]
} | 0.9 |
co_hall_00106 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CAMK4 GENE_ENCODES_PROTEIN CAMK4 -> CAMK4 PROTEIN_PHYSICALLY_INTERACTS_WITH CABIN1 -> CABIN1 GENE_ENCODES_PROTEIN CABIN1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CAMK4",
"source_node_type": "GENE",
"source_node_label": "CAMK4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "814"... | D | [
"A. ESR1 interacts with ACTR3",
"B. MET interacts with SPSB4",
"C. CAMK4 interacts with CABIN1",
"D. PIAS2 interacts with SEPT8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CAMK4",
"source_db": "UniProt",
"payload": {
"accession": "Q16566",
"sequence": "MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEK... | [
{
"source_db": "bridge",
"source_id": "814",
"text": "CAMK4 GENE_ENCODES_PROTEIN CAMK4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "23523",
"text": "CAMK4 PROTEIN_PHYSICALLY_INTERACTS_WITH CABIN1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "PIAS2 interacts with SEPT8",
"real_options": [
"CAMK4 interacts with CABIN1",
"MET interacts with SPSB4",
"ESR1 interacts with ACTR3"
]
} | 0.9 |
co_hall_00107 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HIF1A GENE_ENCODES_PROTEIN HIF1A -> HIF1A PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HIF1A",
"source_node_type": "PROTEIN",
"source_node_label": "HIF1A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3... | C | [
"A. HIF1A interacts with CTNNB1",
"B. SQSTM1 interacts with FHOD3",
"C. HOXC10 interacts with UBE2O",
"D. SPOP interacts with BAZ1A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "3091",
"text": "HIF1A GENE_ENCODES_PROTEIN HIF1A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "HIF1A PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "HOXC10 interacts with UBE2O",
"real_options": [
"HIF1A interacts with CTNNB1",
"SQSTM1 interacts with FHOD3",
"SPOP interacts with BAZ1A"
]
} | 0.9 |
co_hall_00108 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH MAP3K13 -> MAP3K13 GENE_ENCODES_PROTEIN MAP3K13 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | C | [
"A. SOX2 interacts with MAP3K13",
"B. ESR1 interacts with CALM1",
"C. MAP1LC3C interacts with ENSP00000639402",
"D. ACVR1 interacts with FKBP1A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9175",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH MAP3K13",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "MAP1LC3C interacts with ENSP00000639402",
"real_options": [
"SOX2 interacts with MAP3K13",
"ESR1 interacts with CALM1",
"ACVR1 interacts with FKBP1A"
]
} | 0.9 |
co_hall_00109 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SDCBP -> SDCBP GENE_ENCODES_PROTEIN SDCBP | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | A | [
"A. EIF3F interacts with IRS2",
"B. SOX2 interacts with SDCBP",
"C. KDM6A interacts with RNF114",
"D. SOX2 interacts with LIN28A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6386",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SDCBP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "EIF3F interacts with IRS2",
"real_options": [
"SOX2 interacts with SDCBP",
"KDM6A interacts with RNF114",
"SOX2 interacts with LIN28A"
]
} | 0.9 |
co_hall_00110 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH SNW1 -> SNW1 GENE_ENCODES_PROTEIN SNW1 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | D | [
"A. SOX2 interacts with RPS15",
"B. MYC interacts with SNW1",
"C. ARNT interacts with ESR1",
"D. ENSP00000309428 interacts with RAB35"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "22938",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH SNW1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "ENSP00000309428 interacts with RAB35",
"real_options": [
"MYC interacts with SNW1",
"ARNT interacts with ESR1",
"SOX2 interacts with RPS15"
]
} | 0.9 |
co_hall_00111 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HUWE1 GENE_ENCODES_PROTEIN HUWE1 -> HUWE1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HUWE1",
"source_node_type": "GENE",
"source_node_label": "HUWE1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1007... | B | [
"A. HUWE1 interacts with CTNNB1",
"B. DUT interacts with ENSP00000640615",
"C. KMT2D interacts with MEN1",
"D. UBQLN2 interacts with TRIM5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "10075",
"text": "HUWE1 GENE_ENCODES_PROTEIN HUWE1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "HUWE1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "DUT interacts with ENSP00000640615",
"real_options": [
"HUWE1 interacts with CTNNB1",
"UBQLN2 interacts with TRIM5",
"KMT2D interacts with MEN1"
]
} | 0.9 |
co_hall_00112 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AKT1 GENE_ENCODES_PROTEIN AKT1 -> AKT1 PROTEIN_PHYSICALLY_INTERACTS_WITH FANCA -> FANCA GENE_ENCODES_PROTEIN FANCA | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT1",
"source_node_type": "GENE",
"source_node_label": "AKT1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "207",
... | A | [
"A. ENSP00000459490 interacts with ENSP00000734384",
"B. ESR1 interacts with SP1",
"C. AKT1 interacts with AKT1S1",
"D. AKT1 interacts with FANCA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT1",
"source_db": "UniProt",
"payload": {
"accession": "P31749",
"sequence": "MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEM... | [
{
"source_db": "bridge",
"source_id": "207",
"text": "AKT1 GENE_ENCODES_PROTEIN AKT1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2175",
"text": "AKT1 PROTEIN_PHYSICALLY_INTERACTS_WITH FANCA",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "ENSP00000459490 interacts with ENSP00000734384",
"real_options": [
"AKT1 interacts with FANCA",
"AKT1 interacts with AKT1S1",
"ESR1 interacts with SP1"
]
} | 0.9 |
co_hall_00113 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SNCA GENE_ENCODES_PROTEIN SNCA -> SNCA PROTEIN_PHYSICALLY_INTERACTS_WITH CTNND1 -> CTNND1 GENE_ENCODES_PROTEIN CTNND1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SNCA",
"source_node_type": "GENE",
"source_node_label": "SNCA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6622",... | C | [
"A. SNCA interacts with CTNND1",
"B. PIK3CA interacts with GJA1",
"C. KIF5C interacts with GPS1",
"D. POLD1 interacts with UPF1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SNCA",
"source_db": "UniProt",
"payload": {
"accession": "P37840",
"sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQ... | [
{
"source_db": "bridge",
"source_id": "6622",
"text": "SNCA GENE_ENCODES_PROTEIN SNCA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1500",
"text": "SNCA PROTEIN_PHYSICALLY_INTERACTS_WITH CTNND1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "KIF5C interacts with GPS1",
"real_options": [
"SNCA interacts with CTNND1",
"POLD1 interacts with UPF1",
"PIK3CA interacts with GJA1"
]
} | 0.9 |
co_hall_00114 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH OPA1 -> OPA1 GENE_ENCODES_PROTEIN OPA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | B | [
"A. VCP interacts with CALB2",
"B. EPHB3 interacts with ATXN2",
"C. C9orf72 interacts with OPA1",
"D. CSNK2A1 interacts with PPP1R1B"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4976",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH OPA1",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "EPHB3 interacts with ATXN2",
"real_options": [
"C9orf72 interacts with OPA1",
"CSNK2A1 interacts with PPP1R1B",
"VCP interacts with CALB2"
]
} | 0.9 |
co_hall_00115 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BCL2L12 GENE_ENCODES_PROTEIN BCL2L12 -> BCL2L12 PROTEIN_PHYSICALLY_INTERACTS_WITH BAX -> BAX GENE_ENCODES_PROTEIN BAX | {
"steps": [
{
"hop": 1,
"source_node_id": "BCL2L12",
"source_node_type": "GENE",
"source_node_label": "BCL2L12",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. TP53BP1 interacts with BLM",
"B. UBQLN2 interacts with PSMD3",
"C. SIM2 interacts with ENSP00000575702",
"D. BCL2L12 interacts with BAX"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BAX",
"source_db": "UniProt",
"payload": {
"accession": "Q07812",
"sequence": "MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRT... | [
{
"source_db": "bridge",
"source_id": "83596",
"text": "BCL2L12 GENE_ENCODES_PROTEIN BCL2L12",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "581",
"text": "BCL2L12 PROTEIN_PHYSICALLY_INTERACTS_WITH BAX",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "SIM2 interacts with ENSP00000575702",
"real_options": [
"BCL2L12 interacts with BAX",
"UBQLN2 interacts with PSMD3",
"TP53BP1 interacts with BLM"
]
} | 0.9 |
co_hall_00116 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PSMG3 GENE_ENCODES_PROTEIN PSMG3 -> PSMG3 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6 -> PSMA6 GENE_ENCODES_PROTEIN PSMA6 | {
"steps": [
{
"hop": 1,
"source_node_id": "PSMG3",
"source_node_type": "GENE",
"source_node_label": "PSMG3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8426... | D | [
"A. PSMG3 interacts with PSMA6",
"B. EGFR interacts with PTEN",
"C. BRCA2 interacts with MYH14",
"D. NUAK2 interacts with ENSP00000757480"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSMA6",
"source_db": "UniProt",
"payload": {
"accession": "P60900",
"sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRP... | [
{
"source_db": "bridge",
"source_id": "84262",
"text": "PSMG3 GENE_ENCODES_PROTEIN PSMG3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5687",
"text": "PSMG3 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "NUAK2 interacts with ENSP00000757480",
"real_options": [
"PSMG3 interacts with PSMA6",
"EGFR interacts with PTEN",
"BRCA2 interacts with MYH14"
]
} | 0.9 |
co_hall_00117 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TRIM21 GENE_ENCODES_PROTEIN TRIM21 -> TRIM21 PROTEIN_PHYSICALLY_INTERACTS_WITH OPTN -> OPTN GENE_ENCODES_PROTEIN OPTN | {
"steps": [
{
"hop": 1,
"source_node_id": "TRIM21",
"source_node_type": "PROTEIN",
"source_node_label": "TRIM21",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | C | [
"A. TRIM21 interacts with OPTN",
"B. PTEN interacts with CSNK2A1",
"C. ENSP00000389854 interacts with NCL",
"D. BRD4 interacts with ASXL1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "OPTN",
"source_db": "UniProt",
"payload": {
"accession": "Q96CV9",
"sequence": "MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA... | [
{
"source_db": "bridge",
"source_id": "6737",
"text": "TRIM21 GENE_ENCODES_PROTEIN TRIM21",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10133",
"text": "TRIM21 PROTEIN_PHYSICALLY_INTERACTS_WITH OPTN",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "ENSP00000389854 interacts with NCL",
"real_options": [
"TRIM21 interacts with OPTN",
"PTEN interacts with CSNK2A1",
"BRD4 interacts with ASXL1"
]
} | 0.9 |
co_hall_00118 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SNCA GENE_ENCODES_PROTEIN SNCA -> SNCA PROTEIN_PHYSICALLY_INTERACTS_WITH IGH -> IGH GENE_ENCODES_PROTEIN IGH | {
"steps": [
{
"hop": 1,
"source_node_id": "SNCA",
"source_node_type": "GENE",
"source_node_label": "SNCA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6622",... | A | [
"A. ENSP00000788647 interacts with MCM4",
"B. SNCA interacts with IGH",
"C. C9orf72 interacts with HUWE1",
"D. ASXL2 interacts with ALB"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SNCA",
"source_db": "UniProt",
"payload": {
"accession": "P37840",
"sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQ... | [
{
"source_db": "bridge",
"source_id": "6622",
"text": "SNCA GENE_ENCODES_PROTEIN SNCA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3492",
"text": "SNCA PROTEIN_PHYSICALLY_INTERACTS_WITH IGH",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "ENSP00000788647 interacts with MCM4",
"real_options": [
"SNCA interacts with IGH",
"C9orf72 interacts with HUWE1",
"ASXL2 interacts with ALB"
]
} | 0.9 |
co_hall_00119 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | NEK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CHCHD10 | {
"steps": [
{
"hop": 1,
"source_node_id": "NEK1",
"source_node_type": "GENE",
"source_node_label": "NEK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.733,
"edge_source_db": "STRING",
"t... | B | [
"A. NEK1 interacts with CHCHD10",
"B. ENSP00000806919 interacts with MLST8",
"C. ADRA2C interacts with GNA11",
"D. MAPK1 interacts with PRDX6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NEK1",
"source_db": "UniProt",
"payload": {
"accession": "Q96PY6",
"sequence": "MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNI... | [
{
"source_db": "STRING",
"source_id": "CHCHD10",
"text": "NEK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CHCHD10",
"confidence": 0.733
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000806919 interacts with MLST8",
"real_options": [
"NEK1 interacts with CHCHD10",
"ADRA2C interacts with GNA11",
"MAPK1 interacts with PRDX6"
]
} | 0.733 |
co_hall_00120 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH NMNAT1 -> NMNAT1 GENE_ENCODES_PROTEIN NMNAT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | C | [
"A. CASP3 interacts with PTGES3",
"B. C9orf72 interacts with KEAP1",
"C. ENSP00000719226 interacts with CAB39L",
"D. SOX2 interacts with NMNAT1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "64802",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH NMNAT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000719226 interacts with CAB39L",
"real_options": [
"SOX2 interacts with NMNAT1",
"CASP3 interacts with PTGES3",
"C9orf72 interacts with KEAP1"
]
} | 0.9 |
co_hall_00121 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR -> EGFR GENE_ENCODES_PROTEIN EGFR | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | C | [
"A. EGFR interacts with EGFR",
"B. CCND1 interacts with SQSTM1",
"C. ENSP00000601589 interacts with ENSP00000510283",
"D. AXL interacts with LCK"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1956",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "ENSP00000601589 interacts with ENSP00000510283",
"real_options": [
"EGFR interacts with EGFR",
"CCND1 interacts with SQSTM1",
"AXL interacts with LCK"
]
} | 0.9 |
co_hall_00122 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HERC5 GENE_ENCODES_PROTEIN HERC5 -> HERC5 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "HERC5",
"source_node_type": "GENE",
"source_node_label": "HERC5",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5119... | C | [
"A. JAK2 interacts with DNAJA3",
"B. CBL interacts with HIST1H2BB",
"C. ENSP00000750892 interacts with DCN",
"D. HERC5 interacts with TP53"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "51191",
"text": "HERC5 GENE_ENCODES_PROTEIN HERC5",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "HERC5 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "ENSP00000750892 interacts with DCN",
"real_options": [
"HERC5 interacts with TP53",
"JAK2 interacts with DNAJA3",
"CBL interacts with HIST1H2BB"
]
} | 0.9 |
co_hall_00123 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PPP2R1B GENE_ENCODES_PROTEIN PPP2R1B -> PPP2R1B PROTEIN_PHYSICALLY_INTERACTS_WITH UNC5B -> UNC5B GENE_ENCODES_PROTEIN UNC5B | {
"steps": [
{
"hop": 1,
"source_node_id": "PPP2R1B",
"source_node_type": "GENE",
"source_node_label": "PPP2R1B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | D | [
"A. RNF32 interacts with APP",
"B. ZAP70 interacts with ABL1",
"C. PPP2R1B interacts with UNC5B",
"D. SLX4 interacts with GSN"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PPP2R1B",
"source_db": "UniProt",
"payload": {
"accession": "P30154",
"sequence": "MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEH... | [
{
"source_db": "bridge",
"source_id": "5519",
"text": "PPP2R1B GENE_ENCODES_PROTEIN PPP2R1B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "219699",
"text": "PPP2R1B PROTEIN_PHYSICALLY_INTERACTS_WITH UNC5B",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "SLX4 interacts with GSN",
"real_options": [
"PPP2R1B interacts with UNC5B",
"RNF32 interacts with APP",
"ZAP70 interacts with ABL1"
]
} | 0.9 |
co_hall_00124 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VHL GENE_ENCODES_PROTEIN VHL -> VHL PROTEIN_PHYSICALLY_INTERACTS_WITH JAK2 -> JAK2 GENE_ENCODES_PROTEIN JAK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "VHL",
"source_node_type": "PROTEIN",
"source_node_label": "VHL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7428"... | B | [
"A. ERCC6 interacts with POLD1",
"B. MRPL36 interacts with ENSP00000423761",
"C. FBXL14 interacts with MYC",
"D. VHL interacts with JAK2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "bridge",
"source_id": "7428",
"text": "VHL GENE_ENCODES_PROTEIN VHL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3717",
"text": "VHL PROTEIN_PHYSICALLY_INTERACTS_WITH JAK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"mode": "interaction",
"fabricated": "MRPL36 interacts with ENSP00000423761",
"real_options": [
"VHL interacts with JAK2",
"ERCC6 interacts with POLD1",
"FBXL14 interacts with MYC"
]
} | 0.9 |
co_hall_00125 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | REST GENE_ENCODES_PROTEIN REST -> REST PROTEIN_PHYSICALLY_INTERACTS_WITH SIN3A -> SIN3A GENE_ENCODES_PROTEIN SIN3A | {
"steps": [
{
"hop": 1,
"source_node_id": "REST",
"source_node_type": "GENE",
"source_node_label": "REST",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5978",... | C | [
"A. REST interacts with SIN3A",
"B. SOX2 interacts with MYO1E",
"C. ENSP00000334886 interacts with MYO6",
"D. PTEN interacts with TNKS"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "REST",
"source_db": "UniProt",
"payload": {
"accession": "Q13127",
"sequence": "MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVEPQPVFEASGAPDIY... | [
{
"source_db": "bridge",
"source_id": "5978",
"text": "REST GENE_ENCODES_PROTEIN REST",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "25942",
"text": "REST PROTEIN_PHYSICALLY_INTERACTS_WITH SIN3A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000334886 interacts with MYO6",
"real_options": [
"REST interacts with SIN3A",
"SOX2 interacts with MYO1E",
"PTEN interacts with TNKS"
]
} | 0.9 |
co_hall_00126 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PPP2R2B GENE_ENCODES_PROTEIN PPP2R2B -> PPP2R2B PROTEIN_PHYSICALLY_INTERACTS_WITH PRPH -> PRPH GENE_ENCODES_PROTEIN PRPH | {
"steps": [
{
"hop": 1,
"source_node_id": "PPP2R2B",
"source_node_type": "GENE",
"source_node_label": "PPP2R2B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | B | [
"A. AR interacts with CHD7",
"B. MAD2L2 interacts with PDCD5",
"C. PPP2R2B interacts with PRPH",
"D. KDM2A interacts with ESR1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PRPH",
"source_db": "UniProt",
"payload": {
"accession": "P41219",
"sequence": "MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARG... | [
{
"source_db": "bridge",
"source_id": "5521",
"text": "PPP2R2B GENE_ENCODES_PROTEIN PPP2R2B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5630",
"text": "PPP2R2B PROTEIN_PHYSICALLY_INTERACTS_WITH PRPH",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"mode": "interaction",
"fabricated": "MAD2L2 interacts with PDCD5",
"real_options": [
"PPP2R2B interacts with PRPH",
"AR interacts with CHD7",
"KDM2A interacts with ESR1"
]
} | 0.9 |
co_hall_00127 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | NEDD4 GENE_ENCODES_PROTEIN NEDD4 -> NEDD4 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1 -> TBK1 GENE_ENCODES_PROTEIN TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "NEDD4",
"source_node_type": "PROTEIN",
"source_node_label": "NEDD4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4... | B | [
"A. ASAH1 interacts with ASAH2",
"B. CKMT1B interacts with SLU7",
"C. CREBBP interacts with HIF1A",
"D. NEDD4 interacts with TBK1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "bridge",
"source_id": "4734",
"text": "NEDD4 GENE_ENCODES_PROTEIN NEDD4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29110",
"text": "NEDD4 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "CKMT1B interacts with SLU7",
"real_options": [
"NEDD4 interacts with TBK1",
"CREBBP interacts with HIF1A",
"ASAH1 interacts with ASAH2"
]
} | 0.9 |
co_hall_00128 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BCL2 GENE_ENCODES_PROTEIN BCL2 -> BCL2 PROTEIN_PHYSICALLY_INTERACTS_WITH SERPINB8 -> SERPINB8 GENE_ENCODES_PROTEIN SERPINB8 | {
"steps": [
{
"hop": 1,
"source_node_id": "BCL2",
"source_node_type": "GENE",
"source_node_label": "BCL2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "596",
... | C | [
"A. CREBBP interacts with SRF",
"B. BCL2 interacts with SERPINB8",
"C. PCBP1 interacts with CD1E",
"D. ATM interacts with NFAT5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCL2",
"source_db": "UniProt",
"payload": {
"accession": "P10415",
"sequence": "MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVV... | [
{
"source_db": "bridge",
"source_id": "596",
"text": "BCL2 GENE_ENCODES_PROTEIN BCL2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5271",
"text": "BCL2 PROTEIN_PHYSICALLY_INTERACTS_WITH SERPINB8",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "PCBP1 interacts with CD1E",
"real_options": [
"BCL2 interacts with SERPINB8",
"ATM interacts with NFAT5",
"CREBBP interacts with SRF"
]
} | 0.9 |
co_hall_00129 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | WASL GENE_ENCODES_PROTEIN WASL -> WASL PROTEIN_PHYSICALLY_INTERACTS_WITH PFN1 -> PFN1 GENE_ENCODES_PROTEIN PFN1 | {
"steps": [
{
"hop": 1,
"source_node_id": "WASL",
"source_node_type": "GENE",
"source_node_label": "WASL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8976",... | B | [
"A. SNCA interacts with MKI67",
"B. SUFU interacts with ENSP00000712219",
"C. WASL interacts with PFN1",
"D. RHOJ interacts with EGFR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PFN1",
"source_db": "UniProt",
"payload": {
"accession": "P07737",
"sequence": "MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASH... | [
{
"source_db": "bridge",
"source_id": "8976",
"text": "WASL GENE_ENCODES_PROTEIN WASL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5216",
"text": "WASL PROTEIN_PHYSICALLY_INTERACTS_WITH PFN1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "SUFU interacts with ENSP00000712219",
"real_options": [
"WASL interacts with PFN1",
"RHOJ interacts with EGFR",
"SNCA interacts with MKI67"
]
} | 0.9 |
co_hall_00130 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FLT3 GENE_ENCODES_PROTEIN FLT3 -> FLT3 PROTEIN_PHYSICALLY_INTERACTS_WITH GAGE12I -> GAGE12I GENE_ENCODES_PROTEIN GAGE12I | {
"steps": [
{
"hop": 1,
"source_node_id": "FLT3",
"source_node_type": "GENE",
"source_node_label": "FLT3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2322",... | B | [
"A. PALB2 interacts with AASDH",
"B. HIST1H2AH interacts with ARIH2",
"C. C9orf72 interacts with NAP1L4",
"D. FLT3 interacts with GAGE12I"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FLT3",
"source_db": "UniProt",
"payload": {
"accession": "P36888",
"sequence": "MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMT... | [
{
"source_db": "bridge",
"source_id": "2322",
"text": "FLT3 GENE_ENCODES_PROTEIN FLT3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "26748",
"text": "FLT3 PROTEIN_PHYSICALLY_INTERACTS_WITH GAGE12I",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "HIST1H2AH interacts with ARIH2",
"real_options": [
"FLT3 interacts with GAGE12I",
"PALB2 interacts with AASDH",
"C9orf72 interacts with NAP1L4"
]
} | 0.9 |
co_hall_00131 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | STAT3 GENE_ENCODES_PROTEIN STAT3 -> STAT3 PROTEIN_PHYSICALLY_INTERACTS_WITH PGR -> PGR GENE_ENCODES_PROTEIN PGR | {
"steps": [
{
"hop": 1,
"source_node_id": "STAT3",
"source_node_type": "PROTEIN",
"source_node_label": "STAT3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6... | C | [
"A. CYLD interacts with TP53",
"B. STAT3 interacts with PGR",
"C. ENSP00000508926 interacts with GRIN1",
"D. DLGAP4 interacts with BIN1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PGR",
"source_db": "UniProt",
"payload": {
"accession": "P06401",
"sequence": "MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACE... | [
{
"source_db": "bridge",
"source_id": "6774",
"text": "STAT3 GENE_ENCODES_PROTEIN STAT3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5241",
"text": "STAT3 PROTEIN_PHYSICALLY_INTERACTS_WITH PGR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000508926 interacts with GRIN1",
"real_options": [
"STAT3 interacts with PGR",
"DLGAP4 interacts with BIN1",
"CYLD interacts with TP53"
]
} | 0.9 |
co_hall_00132 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PDCD6 GENE_ENCODES_PROTEIN PDCD6 -> PDCD6 PROTEIN_PHYSICALLY_INTERACTS_WITH ANXA11 -> ANXA11 GENE_ENCODES_PROTEIN ANXA11 | {
"steps": [
{
"hop": 1,
"source_node_id": "PDCD6",
"source_node_type": "PROTEIN",
"source_node_label": "PDCD6",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1... | C | [
"A. PDCD6 interacts with ANXA11",
"B. BRCA1 interacts with HDLBP",
"C. FANCM interacts with LARP1",
"D. BRCA2 interacts with DYNC1LI2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ANXA11",
"source_db": "UniProt",
"payload": {
"accession": "P50995",
"sequence": "MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQP... | [
{
"source_db": "bridge",
"source_id": "10016",
"text": "PDCD6 GENE_ENCODES_PROTEIN PDCD6",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "311",
"text": "PDCD6 PROTEIN_PHYSICALLY_INTERACTS_WITH ANXA11",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "FANCM interacts with LARP1",
"real_options": [
"PDCD6 interacts with ANXA11",
"BRCA1 interacts with HDLBP",
"BRCA2 interacts with DYNC1LI2"
]
} | 0.9 |
co_hall_00133 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SMCR8 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000727900 interacts with ENSP00000503131",
"B. C9orf72 interacts with SMCR8",
"C. BARD1 interacts with MSH2",
"D. MET interacts with ATAD3A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "STRING",
"source_id": "SMCR8",
"text": "C9orf72 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SMCR8",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000727900 interacts with ENSP00000503131",
"real_options": [
"C9orf72 interacts with SMCR8",
"BARD1 interacts with MSH2",
"MET interacts with ATAD3A"
]
} | 0.999 |
co_hall_00134 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH FBXO31 -> FBXO31 GENE_ENCODES_PROTEIN FBXO31 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | B | [
"A. TP53 interacts with ECD",
"B. ENSP00000633644 interacts with ENSP00000788743",
"C. MYC interacts with FBXO31",
"D. VDR interacts with RXRA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "79791",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH FBXO31",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "ENSP00000633644 interacts with ENSP00000788743",
"real_options": [
"MYC interacts with FBXO31",
"VDR interacts with RXRA",
"TP53 interacts with ECD"
]
} | 0.9 |
co_hall_00135 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH SMAD4 -> SMAD4 GENE_ENCODES_PROTEIN SMAD4 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | A | [
"A. ENSP00000618763 interacts with ENSP00000777787",
"B. ACHE interacts with COL4A1",
"C. AR interacts with SMAD4",
"D. C9orf72 interacts with EIF3I"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4089",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH SMAD4",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "SMA... | {
"mode": "interaction",
"fabricated": "ENSP00000618763 interacts with ENSP00000777787",
"real_options": [
"AR interacts with SMAD4",
"ACHE interacts with COL4A1",
"C9orf72 interacts with EIF3I"
]
} | 0.9 |
co_hall_00136 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | GRAP2 GENE_ENCODES_PROTEIN GRAP2 -> GRAP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL -> CBL GENE_ENCODES_PROTEIN CBL | {
"steps": [
{
"hop": 1,
"source_node_id": "GRAP2",
"source_node_type": "GENE",
"source_node_label": "GRAP2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9402... | B | [
"A. CTNNA1 interacts with CD44",
"B. DEAF1 interacts with ENSP00000226359",
"C. C9orf72 interacts with SEC13",
"D. GRAP2 interacts with CBL"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "9402",
"text": "GRAP2 GENE_ENCODES_PROTEIN GRAP2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "867",
"text": "GRAP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "DEAF1 interacts with ENSP00000226359",
"real_options": [
"GRAP2 interacts with CBL",
"C9orf72 interacts with SEC13",
"CTNNA1 interacts with CD44"
]
} | 0.9 |
co_hall_00137 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VHL GENE_ENCODES_PROTEIN VHL -> VHL PROTEIN_PHYSICALLY_INTERACTS_WITH AR -> AR GENE_ENCODES_PROTEIN AR | {
"steps": [
{
"hop": 1,
"source_node_id": "VHL",
"source_node_type": "PROTEIN",
"source_node_label": "VHL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7428"... | A | [
"A. DDX3X interacts with ARFGEF2",
"B. TP53 interacts with RING1",
"C. VHL interacts with AR",
"D. KRAS interacts with MAPKAP1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "7428",
"text": "VHL GENE_ENCODES_PROTEIN VHL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "367",
"text": "VHL PROTEIN_PHYSICALLY_INTERACTS_WITH AR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "AR"... | {
"mode": "interaction",
"fabricated": "DDX3X interacts with ARFGEF2",
"real_options": [
"VHL interacts with AR",
"KRAS interacts with MAPKAP1",
"TP53 interacts with RING1"
]
} | 0.9 |
co_hall_00138 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CD274 GENE_ENCODES_PROTEIN CD274 -> CD274 PROTEIN_PHYSICALLY_INTERACTS_WITH MSN -> MSN GENE_ENCODES_PROTEIN MSN | {
"steps": [
{
"hop": 1,
"source_node_id": "CD274",
"source_node_type": "GENE",
"source_node_label": "CD274",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2912... | B | [
"A. CD274 interacts with MSN",
"B. ENSP00000309392 interacts with ENSP00000542587",
"C. VCP interacts with EEF1B2",
"D. HUWE1 interacts with BRCA1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD274",
"source_db": "UniProt",
"payload": {
"accession": "Q9NZQ7",
"sequence": "MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAP... | [
{
"source_db": "bridge",
"source_id": "29126",
"text": "CD274 GENE_ENCODES_PROTEIN CD274",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4478",
"text": "CD274 PROTEIN_PHYSICALLY_INTERACTS_WITH MSN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000309392 interacts with ENSP00000542587",
"real_options": [
"CD274 interacts with MSN",
"HUWE1 interacts with BRCA1",
"VCP interacts with EEF1B2"
]
} | 0.9 |
co_hall_00139 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TECR -> TECR GENE_ENCODES_PROTEIN TECR | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | B | [
"A. CREBBP interacts with PPARG",
"B. ANKZF1 interacts with MRPL10",
"C. BCAR1 interacts with ABL1",
"D. C9orf72 interacts with TECR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9524",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TECR",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ANKZF1 interacts with MRPL10",
"real_options": [
"C9orf72 interacts with TECR",
"BCAR1 interacts with ABL1",
"CREBBP interacts with PPARG"
]
} | 0.9 |
co_hall_00140 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EARS2 -> EARS2 GENE_ENCODES_PROTEIN EARS2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. C9orf72 interacts with EARS2",
"B. PPP2R1B interacts with RORC",
"C. ENSP00000745007 interacts with ENSP00000506726",
"D. MCRS1 interacts with RET"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "124454",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EARS2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000745007 interacts with ENSP00000506726",
"real_options": [
"C9orf72 interacts with EARS2",
"PPP2R1B interacts with RORC",
"MCRS1 interacts with RET"
]
} | 0.9 |
co_hall_00141 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SMAD2 GENE_ENCODES_PROTEIN SMAD2 -> SMAD2 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP -> CREBBP GENE_ENCODES_PROTEIN CREBBP | {
"steps": [
{
"hop": 1,
"source_node_id": "SMAD2",
"source_node_type": "PROTEIN",
"source_node_label": "SMAD2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4... | B | [
"A. FLT3 interacts with DCC",
"B. LINC01139 interacts with ERC1",
"C. UBE2I interacts with CDK1",
"D. SMAD2 interacts with CREBBP"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "4087",
"text": "SMAD2 GENE_ENCODES_PROTEIN SMAD2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1387",
"text": "SMAD2 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "LINC01139 interacts with ERC1",
"real_options": [
"SMAD2 interacts with CREBBP",
"FLT3 interacts with DCC",
"UBE2I interacts with CDK1"
]
} | 0.9 |
co_hall_00142 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BLM GENE_ENCODES_PROTEIN BLM -> BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "BLM",
"source_node_type": "GENE",
"source_node_label": "BLM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "641",
... | A | [
"A. ENSP00000631294 interacts with ENSP00000501514",
"B. MET interacts with HSPA1A",
"C. BLM interacts with TP53",
"D. LRRK2 interacts with GAK"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BLM",
"source_db": "UniProt",
"payload": {
"accession": "P54132",
"sequence": "MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTA... | [
{
"source_db": "bridge",
"source_id": "641",
"text": "BLM GENE_ENCODES_PROTEIN BLM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "T... | {
"mode": "interaction",
"fabricated": "ENSP00000631294 interacts with ENSP00000501514",
"real_options": [
"BLM interacts with TP53",
"MET interacts with HSPA1A",
"LRRK2 interacts with GAK"
]
} | 0.9 |
co_hall_00143 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CLEC16A GENE_ENCODES_PROTEIN CLEC16A -> CLEC16A PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB -> AURKB GENE_ENCODES_PROTEIN AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "CLEC16A",
"source_node_type": "GENE",
"source_node_label": "CLEC16A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | D | [
"A. HERC5 interacts with NLRP3",
"B. ESR1 interacts with TP53BP1",
"C. CLEC16A interacts with AURKB",
"D. RUNX1 interacts with FBXL14"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKB",
"source_db": "UniProt",
"payload": {
"accession": "Q96GD4",
"sequence": "MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH... | [
{
"source_db": "bridge",
"source_id": "23274",
"text": "CLEC16A GENE_ENCODES_PROTEIN CLEC16A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9212",
"text": "CLEC16A PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "RUNX1 interacts with FBXL14",
"real_options": [
"CLEC16A interacts with AURKB",
"HERC5 interacts with NLRP3",
"ESR1 interacts with TP53BP1"
]
} | 0.9 |
co_hall_00144 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH CAV3 -> CAV3 GENE_ENCODES_PROTEIN CAV3 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | D | [
"A. EGFR interacts with CAV3",
"B. ZRANB1 interacts with CHMP2B",
"C. CD4 interacts with CD8A",
"D. BECN1 interacts with SLC17A8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "859",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH CAV3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "BECN1 interacts with SLC17A8",
"real_options": [
"EGFR interacts with CAV3",
"ZRANB1 interacts with CHMP2B",
"CD4 interacts with CD8A"
]
} | 0.9 |
co_hall_00145 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | E4F1 GENE_ENCODES_PROTEIN E4F1 -> E4F1 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A -> CDKN2A GENE_ENCODES_PROTEIN CDKN2A | {
"steps": [
{
"hop": 1,
"source_node_id": "E4F1",
"source_node_type": "GENE",
"source_node_label": "E4F1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1877",... | B | [
"A. EGFR interacts with ANKRD13A",
"B. ENSP00000526467 interacts with UBE2O",
"C. CDH1 interacts with CSE1L",
"D. E4F1 interacts with CDKN2A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN2A",
"source_db": "UniProt",
"payload": {
"accession": "Q8N726",
"sequence": "MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG... | [
{
"source_db": "bridge",
"source_id": "1877",
"text": "E4F1 GENE_ENCODES_PROTEIN E4F1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1029",
"text": "E4F1 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000526467 interacts with UBE2O",
"real_options": [
"E4F1 interacts with CDKN2A",
"EGFR interacts with ANKRD13A",
"CDH1 interacts with CSE1L"
]
} | 0.9 |
co_hall_00146 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FBXO11 GENE_ENCODES_PROTEIN FBXO11 -> FBXO11 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "FBXO11",
"source_node_type": "GENE",
"source_node_label": "FBXO11",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "80... | D | [
"A. FBXO11 interacts with TP53",
"B. ERG interacts with NEDD4",
"C. CASP7 interacts with CASP2",
"D. ENSP00000495858 interacts with ENSP00000623108"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "80204",
"text": "FBXO11 GENE_ENCODES_PROTEIN FBXO11",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "FBXO11 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "ENSP00000495858 interacts with ENSP00000623108",
"real_options": [
"FBXO11 interacts with TP53",
"ERG interacts with NEDD4",
"CASP7 interacts with CASP2"
]
} | 0.9 |
co_hall_00147 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ABL1 GENE_ENCODES_PROTEIN ABL1 -> ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH SPTAN1 -> SPTAN1 GENE_ENCODES_PROTEIN SPTAN1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABL1",
"source_node_type": "GENE",
"source_node_label": "ABL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "25",
... | D | [
"A. ABL1 interacts with SPTAN1",
"B. JAK2 interacts with EPOR",
"C. CD2 interacts with CD2AP",
"D. ENSP00000716312 interacts with ENSP00000682696"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "bridge",
"source_id": "25",
"text": "ABL1 GENE_ENCODES_PROTEIN ABL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6709",
"text": "ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH SPTAN1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "ENSP00000716312 interacts with ENSP00000682696",
"real_options": [
"ABL1 interacts with SPTAN1",
"CD2 interacts with CD2AP",
"JAK2 interacts with EPOR"
]
} | 0.9 |
co_hall_00148 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SIRT6 GENE_ENCODES_PROTEIN SIRT6 -> SIRT6 PROTEIN_PHYSICALLY_INTERACTS_WITH FUS -> FUS GENE_ENCODES_PROTEIN FUS | {
"steps": [
{
"hop": 1,
"source_node_id": "SIRT6",
"source_node_type": "PROTEIN",
"source_node_label": "SIRT6",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5... | C | [
"A. BLM interacts with FAN1",
"B. SIRT6 interacts with FUS",
"C. IRF4 interacts with ITK",
"D. FLT3 interacts with CBL"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FUS",
"source_db": "UniProt",
"payload": {
"accession": "P35637",
"sequence": "MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPS... | [
{
"source_db": "bridge",
"source_id": "51548",
"text": "SIRT6 GENE_ENCODES_PROTEIN SIRT6",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2521",
"text": "SIRT6 PROTEIN_PHYSICALLY_INTERACTS_WITH FUS",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "IRF4 interacts with ITK",
"real_options": [
"SIRT6 interacts with FUS",
"BLM interacts with FAN1",
"FLT3 interacts with CBL"
]
} | 0.9 |
co_hall_00149 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ATXN2 GENE_ENCODES_PROTEIN ATXN2 -> ATXN2 PROTEIN_PHYSICALLY_INTERACTS_WITH LARP4 -> LARP4 GENE_ENCODES_PROTEIN LARP4 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATXN2",
"source_node_type": "GENE",
"source_node_label": "ATXN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6311... | C | [
"A. NF1 interacts with FAF2",
"B. PALMD interacts with ATP6V1B2",
"C. ENSP00000629708 interacts with ENSP00000593367",
"D. ATXN2 interacts with LARP4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATXN2",
"source_db": "UniProt",
"payload": {
"accession": "Q99700",
"sequence": "MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASP... | [
{
"source_db": "bridge",
"source_id": "6311",
"text": "ATXN2 GENE_ENCODES_PROTEIN ATXN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "113251",
"text": "ATXN2 PROTEIN_PHYSICALLY_INTERACTS_WITH LARP4",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000629708 interacts with ENSP00000593367",
"real_options": [
"ATXN2 interacts with LARP4",
"PALMD interacts with ATP6V1B2",
"NF1 interacts with FAF2"
]
} | 0.9 |
co_hall_00150 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH USMG5 -> USMG5 GENE_ENCODES_PROTEIN USMG5 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | D | [
"A. UBC interacts with SQSTM1",
"B. CCNE1 interacts with CTNNB1",
"C. SOX2 interacts with USMG5",
"D. PTPN6 interacts with LRRC17"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "84833",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH USMG5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "PTPN6 interacts with LRRC17",
"real_options": [
"SOX2 interacts with USMG5",
"CCNE1 interacts with CTNNB1",
"UBC interacts with SQSTM1"
]
} | 0.9 |
co_hall_00151 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAP1LC3B2 -> MAP1LC3B2 GENE_ENCODES_PROTEIN MAP1LC3B2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | A | [
"A. DNMT3B interacts with CCAAT/enhancer-binding protein alpha",
"B. SOX2 interacts with HSP90AA1",
"C. SQSTM1 interacts with MAP1LC3B2",
"D. MAPK1 interacts with NOXA1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "643246",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAP1LC3B2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "DNMT3B interacts with CCAAT/enhancer-binding protein alpha",
"real_options": [
"SQSTM1 interacts with MAP1LC3B2",
"SOX2 interacts with HSP90AA1",
"MAPK1 interacts with NOXA1"
]
} | 0.9 |
co_hall_00152 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TMEM129 GENE_ENCODES_PROTEIN TMEM129 -> TMEM129 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "TMEM129",
"source_node_type": "GENE",
"source_node_label": "TMEM129",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | B | [
"A. TMEM129 interacts with VCP",
"B. RASSF1 interacts with ENSP00000605570",
"C. PIAS4 interacts with HTT",
"D. ZSWIM7 interacts with RAD51D"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "92305",
"text": "TMEM129 GENE_ENCODES_PROTEIN TMEM129",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "TMEM129 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"mode": "interaction",
"fabricated": "RASSF1 interacts with ENSP00000605570",
"real_options": [
"TMEM129 interacts with VCP",
"ZSWIM7 interacts with RAD51D",
"PIAS4 interacts with HTT"
]
} | 0.9 |
co_hall_00153 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | DYNC1H1 GENE_ENCODES_PROTEIN DYNC1H1 -> DYNC1H1 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "DYNC1H1",
"source_node_type": "PROTEIN",
"source_node_label": "DYNC1H1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id"... | D | [
"A. HGF interacts with MET",
"B. DYNC1H1 interacts with TP53",
"C. ASXL1 interacts with RBBP4",
"D. KCND3 interacts with GINS2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "1778",
"text": "DYNC1H1 GENE_ENCODES_PROTEIN DYNC1H1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "DYNC1H1 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"mode": "interaction",
"fabricated": "KCND3 interacts with GINS2",
"real_options": [
"DYNC1H1 interacts with TP53",
"HGF interacts with MET",
"ASXL1 interacts with RBBP4"
]
} | 0.9 |
co_hall_00154 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SPOP GENE_ENCODES_PROTEIN SPOP -> SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH BAZ1A -> BAZ1A GENE_ENCODES_PROTEIN BAZ1A | {
"steps": [
{
"hop": 1,
"source_node_id": "SPOP",
"source_node_type": "GENE",
"source_node_label": "SPOP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8405",... | D | [
"A. BRCA2 interacts with NPM1",
"B. SPOP interacts with BAZ1A",
"C. HTT interacts with PSME4",
"D. QKI interacts with RNF20"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "8405",
"text": "SPOP GENE_ENCODES_PROTEIN SPOP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "11177",
"text": "SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH BAZ1A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "QKI interacts with RNF20",
"real_options": [
"SPOP interacts with BAZ1A",
"HTT interacts with PSME4",
"BRCA2 interacts with NPM1"
]
} | 0.9 |
co_hall_00155 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH NUP155 -> NUP155 GENE_ENCODES_PROTEIN NUP155 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | D | [
"A. C9orf72 interacts with NUP155",
"B. EGFR interacts with HBEGF",
"C. OTUD7B interacts with ESR1",
"D. OBSL1 interacts with ENSP00000315284"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9631",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH NUP155",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "OBSL1 interacts with ENSP00000315284",
"real_options": [
"C9orf72 interacts with NUP155",
"OTUD7B interacts with ESR1",
"EGFR interacts with HBEGF"
]
} | 0.9 |
co_hall_00156 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | UHRF2 GENE_ENCODES_PROTEIN UHRF2 -> UHRF2 PROTEIN_PHYSICALLY_INTERACTS_WITH CCND1 -> CCND1 GENE_ENCODES_PROTEIN CCND1 | {
"steps": [
{
"hop": 1,
"source_node_id": "UHRF2",
"source_node_type": "GENE",
"source_node_label": "UHRF2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1154... | A | [
"A. CASTOR1 interacts with ENSP00000717619",
"B. PSEN2 interacts with BCL2",
"C. UHRF2 interacts with CCND1",
"D. AKT1 interacts with STK4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CCND1",
"source_db": "UniProt",
"payload": {
"accession": "P24385",
"sequence": "MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIR... | [
{
"source_db": "bridge",
"source_id": "115426",
"text": "UHRF2 GENE_ENCODES_PROTEIN UHRF2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "595",
"text": "UHRF2 PROTEIN_PHYSICALLY_INTERACTS_WITH CCND1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "CASTOR1 interacts with ENSP00000717619",
"real_options": [
"UHRF2 interacts with CCND1",
"PSEN2 interacts with BCL2",
"AKT1 interacts with STK4"
]
} | 0.9 |
co_hall_00157 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MET GENE_ENCODES_PROTEIN MET -> MET PROTEIN_PHYSICALLY_INTERACTS_WITH SOCS1 -> SOCS1 GENE_ENCODES_PROTEIN SOCS1 | {
"steps": [
{
"hop": 1,
"source_node_id": "MET",
"source_node_type": "GENE",
"source_node_label": "MET",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4233",
... | D | [
"A. TBK1 interacts with IRF3",
"B. MET interacts with SOCS1",
"C. HEY2 interacts with NOTCH1",
"D. POSTN interacts with ENSP00000629723"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MET",
"source_db": "UniProt",
"payload": {
"accession": "P08581",
"sequence": "MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGS... | [
{
"source_db": "bridge",
"source_id": "4233",
"text": "MET GENE_ENCODES_PROTEIN MET",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8651",
"text": "MET PROTEIN_PHYSICALLY_INTERACTS_WITH SOCS1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "POSTN interacts with ENSP00000629723",
"real_options": [
"MET interacts with SOCS1",
"HEY2 interacts with NOTCH1",
"TBK1 interacts with IRF3"
]
} | 0.9 |
co_hall_00158 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MSH6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PMS2 | {
"steps": [
{
"hop": 1,
"source_node_id": "MSH6",
"source_node_type": "GENE",
"source_node_label": "MSH6",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. ENSP00000615019 interacts with NRG2",
"B. CHUK interacts with MYC",
"C. MSH6 interacts with PMS2",
"D. C9orf72 interacts with CTR9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MSH6",
"source_db": "UniProt",
"payload": {
"accession": "P52701",
"sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFF... | [
{
"source_db": "STRING",
"source_id": "PMS2",
"text": "MSH6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PMS2",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000615019 interacts with NRG2",
"real_options": [
"MSH6 interacts with PMS2",
"CHUK interacts with MYC",
"C9orf72 interacts with CTR9"
]
} | 0.999 |
co_hall_00159 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH EPHA7 -> EPHA7 GENE_ENCODES_PROTEIN EPHA7 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | B | [
"A. AKT1 interacts with ZRANB1",
"B. DSG3 interacts with PAPOLA",
"C. PSEN2 interacts with PSENEN",
"D. SOX2 interacts with EPHA7"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2045",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH EPHA7",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "DSG3 interacts with PAPOLA",
"real_options": [
"SOX2 interacts with EPHA7",
"PSEN2 interacts with PSENEN",
"AKT1 interacts with ZRANB1"
]
} | 0.9 |
co_hall_00160 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ABL1 GENE_ENCODES_PROTEIN ABL1 -> ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH WASF1 -> WASF1 GENE_ENCODES_PROTEIN WASF1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABL1",
"source_node_type": "GENE",
"source_node_label": "ABL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "25",
... | C | [
"A. EP300 interacts with CCND1",
"B. BRCA1 interacts with IARS",
"C. RRAGA interacts with TMEFF2",
"D. ABL1 interacts with WASF1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "bridge",
"source_id": "25",
"text": "ABL1 GENE_ENCODES_PROTEIN ABL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8936",
"text": "ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH WASF1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "RRAGA interacts with TMEFF2",
"real_options": [
"ABL1 interacts with WASF1",
"EP300 interacts with CCND1",
"BRCA1 interacts with IARS"
]
} | 0.9 |
co_hall_00161 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | REST GENE_ENCODES_PROTEIN REST -> REST PROTEIN_PHYSICALLY_INTERACTS_WITH BTRC -> BTRC GENE_ENCODES_PROTEIN BTRC | {
"steps": [
{
"hop": 1,
"source_node_id": "REST",
"source_node_type": "GENE",
"source_node_label": "REST",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5978",... | D | [
"A. RFPL3 interacts with CREBBP",
"B. REST interacts with BTRC",
"C. CDK2 interacts with BRCA1",
"D. RAB31 interacts with RPTOR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "REST",
"source_db": "UniProt",
"payload": {
"accession": "Q13127",
"sequence": "MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVEPQPVFEASGAPDIY... | [
{
"source_db": "bridge",
"source_id": "5978",
"text": "REST GENE_ENCODES_PROTEIN REST",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8945",
"text": "REST PROTEIN_PHYSICALLY_INTERACTS_WITH BTRC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "RAB31 interacts with RPTOR",
"real_options": [
"REST interacts with BTRC",
"RFPL3 interacts with CREBBP",
"CDK2 interacts with BRCA1"
]
} | 0.9 |
co_hall_00162 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TRIM21 GENE_ENCODES_PROTEIN TRIM21 -> TRIM21 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "TRIM21",
"source_node_type": "PROTEIN",
"source_node_label": "TRIM21",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | D | [
"A. TRIM21 interacts with TP53",
"B. MYC interacts with AKAP8",
"C. NEK7 interacts with NLRP3",
"D. TFRC interacts with KRT2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "6737",
"text": "TRIM21 GENE_ENCODES_PROTEIN TRIM21",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "TRIM21 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "TFRC interacts with KRT2",
"real_options": [
"TRIM21 interacts with TP53",
"NEK7 interacts with NLRP3",
"MYC interacts with AKAP8"
]
} | 0.9 |
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