id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_hall_00163 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BUB1B GENE_ENCODES_PROTEIN BUB1B -> BUB1B PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2 -> HDAC2 GENE_ENCODES_PROTEIN HDAC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "BUB1B",
"source_node_type": "GENE",
"source_node_label": "BUB1B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "701"... | C | [
"A. BUB1B interacts with HDAC2",
"B. CHCHD10 interacts with CHCHD2",
"C. ENSP00000606511 interacts with FLOT2",
"D. USP1 interacts with BIRC5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BUB1B",
"source_db": "UniProt",
"payload": {
"accession": "O60566",
"sequence": "MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCN... | [
{
"source_db": "bridge",
"source_id": "701",
"text": "BUB1B GENE_ENCODES_PROTEIN BUB1B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3066",
"text": "BUB1B PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000606511 interacts with FLOT2",
"real_options": [
"BUB1B interacts with HDAC2",
"CHCHD10 interacts with CHCHD2",
"USP1 interacts with BIRC5"
]
} | 0.9 |
co_hall_00164 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | MYH9 GENE_ENCODES_PROTEIN MYH9 -> MYH9 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC -> MYC GENE_ENCODES_PROTEIN MYC | {
"steps": [
{
"hop": 1,
"source_node_id": "MYH9",
"source_node_type": "GENE",
"source_node_label": "MYH9",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4627",... | A | [
"A. RPS27A_UBE2V2 interacts with GFAP",
"B. CHEK2 interacts with ELAVL1",
"C. C9orf72 interacts with L2HGDH",
"D. MYH9 interacts with MYC"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4627",
"text": "MYH9 GENE_ENCODES_PROTEIN MYH9",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4609",
"text": "MYH9 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "RPS27A_UBE2V2 interacts with GFAP",
"real_options": [
"MYH9 interacts with MYC",
"CHEK2 interacts with ELAVL1",
"C9orf72 interacts with L2HGDH"
]
} | 0.9 |
co_hall_00165 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PSEN1 GENE_ENCODES_PROTEIN PSEN1 -> PSEN1 PROTEIN_PHYSICALLY_INTERACTS_WITH IRAK2 -> IRAK2 GENE_ENCODES_PROTEIN IRAK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "PSEN1",
"source_node_type": "GENE",
"source_node_label": "PSEN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5663... | C | [
"A. SQSTM1 interacts with HTT",
"B. PSEN1 interacts with IRAK2",
"C. ENSP00000451055 interacts with ENSP00000490388",
"D. HDAC4 interacts with ESR1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSEN1",
"source_db": "UniProt",
"payload": {
"accession": "P49768",
"sequence": "MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSI... | [
{
"source_db": "bridge",
"source_id": "5663",
"text": "PSEN1 GENE_ENCODES_PROTEIN PSEN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3656",
"text": "PSEN1 PROTEIN_PHYSICALLY_INTERACTS_WITH IRAK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "ENSP00000451055 interacts with ENSP00000490388",
"real_options": [
"PSEN1 interacts with IRAK2",
"HDAC4 interacts with ESR1",
"SQSTM1 interacts with HTT"
]
} | 0.9 |
co_hall_00166 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH PELO -> PELO GENE_ENCODES_PROTEIN PELO | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. VCP interacts with SFPQ",
"B. C9orf72 interacts with PELO",
"C. ENSP00000559761 interacts with FANCM",
"D. GRB2 interacts with RET"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "53918",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH PELO",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000559761 interacts with FANCM",
"real_options": [
"C9orf72 interacts with PELO",
"GRB2 interacts with RET",
"VCP interacts with SFPQ"
]
} | 0.9 |
co_hall_00167 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FOXO3 GENE_ENCODES_PROTEIN FOXO3 -> FOXO3 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1 -> MAPK1 GENE_ENCODES_PROTEIN MAPK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FOXO3",
"source_node_type": "PROTEIN",
"source_node_label": "FOXO3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2... | C | [
"A. FOXO3 interacts with MAPK1",
"B. AKT1 interacts with NGB",
"C. CDK5RAP2 interacts with IQCJ",
"D. C9orf72 interacts with IGF2BP1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "bridge",
"source_id": "2309",
"text": "FOXO3 GENE_ENCODES_PROTEIN FOXO3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5594",
"text": "FOXO3 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "CDK5RAP2 interacts with IQCJ",
"real_options": [
"FOXO3 interacts with MAPK1",
"AKT1 interacts with NGB",
"C9orf72 interacts with IGF2BP1"
]
} | 0.9 |
co_hall_00168 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1 -> BRCA1 GENE_ENCODES_PROTEIN BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | B | [
"A. BRCA1 interacts with BRCA1",
"B. ENSP00000404865 interacts with ENSP00000500646",
"C. BARD1 interacts with UBE2D3",
"D. CTNNA1 interacts with NAP1L4"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "672",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000404865 interacts with ENSP00000500646",
"real_options": [
"BRCA1 interacts with BRCA1",
"CTNNA1 interacts with NAP1L4",
"BARD1 interacts with UBE2D3"
]
} | 0.9 |
co_hall_00169 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | INTS3 GENE_ENCODES_PROTEIN INTS3 -> INTS3 PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1 -> AKT1 GENE_ENCODES_PROTEIN AKT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "INTS3",
"source_node_type": "GENE",
"source_node_label": "INTS3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6512... | B | [
"A. INTS3 interacts with AKT1",
"B. PRICKLE2 interacts with XBP1",
"C. SQSTM1 interacts with TARDBP",
"D. BRD4 interacts with ERG"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT1",
"source_db": "UniProt",
"payload": {
"accession": "P31749",
"sequence": "MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEM... | [
{
"source_db": "bridge",
"source_id": "65123",
"text": "INTS3 GENE_ENCODES_PROTEIN INTS3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "207",
"text": "INTS3 PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "PRICKLE2 interacts with XBP1",
"real_options": [
"INTS3 interacts with AKT1",
"BRD4 interacts with ERG",
"SQSTM1 interacts with TARDBP"
]
} | 0.9 |
co_hall_00170 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FUT4 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD33",
"source_node_type": "GENE",
"source_node_label": "CD33",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.88,
"edge_source_db": "STRING",
"ta... | C | [
"A. MYC interacts with NMI",
"B. EGFR interacts with RRAD",
"C. SMAD5 interacts with ENSP00000454439",
"D. CD33 interacts with FUT4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD33",
"source_db": "UniProt",
"payload": {
"accession": "P20138",
"sequence": "MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQL... | [
{
"source_db": "STRING",
"source_id": "FUT4",
"text": "CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FUT4",
"confidence": 0.88
}
] | {
"mode": "interaction",
"fabricated": "SMAD5 interacts with ENSP00000454439",
"real_options": [
"CD33 interacts with FUT4",
"EGFR interacts with RRAD",
"MYC interacts with NMI"
]
} | 0.88 |
co_hall_00171 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EYA4 GENE_ENCODES_PROTEIN EYA4 -> EYA4 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1 -> MAPK1 GENE_ENCODES_PROTEIN MAPK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "EYA4",
"source_node_type": "GENE",
"source_node_label": "EYA4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2070",... | C | [
"A. AR interacts with ZMIZ2",
"B. DOT1L interacts with TIA1",
"C. ENSP00000493674 interacts with ENSP00000679391",
"D. EYA4 interacts with MAPK1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "bridge",
"source_id": "2070",
"text": "EYA4 GENE_ENCODES_PROTEIN EYA4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5594",
"text": "EYA4 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "ENSP00000493674 interacts with ENSP00000679391",
"real_options": [
"EYA4 interacts with MAPK1",
"AR interacts with ZMIZ2",
"DOT1L interacts with TIA1"
]
} | 0.9 |
co_hall_00172 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | NOTCH1 GENE_ENCODES_PROTEIN NOTCH1 -> NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH PRKCD -> PRKCD GENE_ENCODES_PROTEIN PRKCD | {
"steps": [
{
"hop": 1,
"source_node_id": "NOTCH1",
"source_node_type": "GENE",
"source_node_label": "NOTCH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "48... | B | [
"A. MYC interacts with FBXO33",
"B. PEX19 interacts with PDCD6",
"C. NOTCH1 interacts with PRKCD",
"D. SMC5 interacts with ALK"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NOTCH1",
"source_db": "UniProt",
"payload": {
"accession": "P46531",
"sequence": "MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG... | [
{
"source_db": "bridge",
"source_id": "4851",
"text": "NOTCH1 GENE_ENCODES_PROTEIN NOTCH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5580",
"text": "NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH PRKCD",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "PEX19 interacts with PDCD6",
"real_options": [
"NOTCH1 interacts with PRKCD",
"MYC interacts with FBXO33",
"SMC5 interacts with ALK"
]
} | 0.9 |
co_hall_00173 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PRR5L GENE_ENCODES_PROTEIN PRR5L -> PRR5L PROTEIN_PHYSICALLY_INTERACTS_WITH MTOR -> MTOR GENE_ENCODES_PROTEIN MTOR | {
"steps": [
{
"hop": 1,
"source_node_id": "PRR5L",
"source_node_type": "GENE",
"source_node_label": "PRR5L",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7989... | B | [
"A. PRR5L interacts with MTOR",
"B. CDX2 interacts with BMP2K",
"C. KMT2D interacts with PAXIP1",
"D. BRCA2 interacts with PCNA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MTOR",
"source_db": "UniProt",
"payload": {
"accession": "P42345",
"sequence": "MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLA... | [
{
"source_db": "bridge",
"source_id": "79899",
"text": "PRR5L GENE_ENCODES_PROTEIN PRR5L",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2475",
"text": "PRR5L PROTEIN_PHYSICALLY_INTERACTS_WITH MTOR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "CDX2 interacts with BMP2K",
"real_options": [
"PRR5L interacts with MTOR",
"BRCA2 interacts with PCNA",
"KMT2D interacts with PAXIP1"
]
} | 0.9 |
co_hall_00174 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BRCA2 GENE_ENCODES_PROTEIN BRCA2 -> BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB -> AURKB GENE_ENCODES_PROTEIN AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA2",
"source_node_type": "GENE",
"source_node_label": "BRCA2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "675"... | A | [
"A. MUC2 interacts with RUNX1T1",
"B. CBL interacts with SRC",
"C. PKM interacts with CDKN1A",
"D. BRCA2 interacts with AURKB"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "675",
"text": "BRCA2 GENE_ENCODES_PROTEIN BRCA2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9212",
"text": "BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "MUC2 interacts with RUNX1T1",
"real_options": [
"BRCA2 interacts with AURKB",
"CBL interacts with SRC",
"PKM interacts with CDKN1A"
]
} | 0.9 |
co_hall_00175 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH TRPT1 -> TRPT1 GENE_ENCODES_PROTEIN TRPT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7157",... | D | [
"A. TP53 interacts with TRPT1",
"B. LATS2 interacts with AR",
"C. POLN interacts with BRIP1",
"D. ZBTB8A interacts with OGG1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "7157",
"text": "TP53 GENE_ENCODES_PROTEIN TP53",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "83707",
"text": "TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH TRPT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ZBTB8A interacts with OGG1",
"real_options": [
"TP53 interacts with TRPT1",
"POLN interacts with BRIP1",
"LATS2 interacts with AR"
]
} | 0.9 |
co_hall_00176 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH STXBP1 -> STXBP1 GENE_ENCODES_PROTEIN STXBP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | B | [
"A. SNCA interacts with PSMC3",
"B. ENSP00000575412 interacts with ENSP00000812739",
"C. ETV1 interacts with SLC45A3",
"D. SQSTM1 interacts with STXBP1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6812",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH STXBP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "ENSP00000575412 interacts with ENSP00000812739",
"real_options": [
"SQSTM1 interacts with STXBP1",
"SNCA interacts with PSMC3",
"ETV1 interacts with SLC45A3"
]
} | 0.9 |
co_hall_00177 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDKN2A GENE_ENCODES_PROTEIN CDKN2A -> CDKN2A PROTEIN_PHYSICALLY_INTERACTS_WITH UCHL1 -> UCHL1 GENE_ENCODES_PROTEIN UCHL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDKN2A",
"source_node_type": "GENE",
"source_node_label": "CDKN2A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10... | A | [
"A. ENSP00000398318 interacts with ENSP00000644915",
"B. BARD1 interacts with UBE2E1",
"C. CDKN2A interacts with UCHL1",
"D. MYC interacts with CCNH"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN2A",
"source_db": "UniProt",
"payload": {
"accession": "Q8N726",
"sequence": "MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG... | [
{
"source_db": "bridge",
"source_id": "1029",
"text": "CDKN2A GENE_ENCODES_PROTEIN CDKN2A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7345",
"text": "CDKN2A PROTEIN_PHYSICALLY_INTERACTS_WITH UCHL1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "ENSP00000398318 interacts with ENSP00000644915",
"real_options": [
"CDKN2A interacts with UCHL1",
"BARD1 interacts with UBE2E1",
"MYC interacts with CCNH"
]
} | 0.9 |
co_hall_00178 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH BRSK1 -> BRSK1 GENE_ENCODES_PROTEIN BRSK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | A | [
"A. ENSP00000434465 interacts with ENSP00000542688",
"B. SOX2 interacts with BRSK1",
"C. POLE interacts with MCM2",
"D. BUB1B interacts with HDAC2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "84446",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH BRSK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000434465 interacts with ENSP00000542688",
"real_options": [
"SOX2 interacts with BRSK1",
"BUB1B interacts with HDAC2",
"POLE interacts with MCM2"
]
} | 0.9 |
co_hall_00179 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BIN1 GENE_ENCODES_PROTEIN BIN1 -> BIN1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACTG1 -> ACTG1 GENE_ENCODES_PROTEIN ACTG1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BIN1",
"source_node_type": "GENE",
"source_node_label": "BIN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "274",
... | C | [
"A. SOX2 interacts with PSMD7",
"B. LARP7 interacts with BARD1",
"C. KIRREL1 interacts with NDUFS2",
"D. BIN1 interacts with ACTG1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIN1",
"source_db": "UniProt",
"payload": {
"accession": "O00499",
"sequence": "MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFP... | [
{
"source_db": "bridge",
"source_id": "274",
"text": "BIN1 GENE_ENCODES_PROTEIN BIN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "71",
"text": "BIN1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACTG1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "KIRREL1 interacts with NDUFS2",
"real_options": [
"BIN1 interacts with ACTG1",
"LARP7 interacts with BARD1",
"SOX2 interacts with PSMD7"
]
} | 0.9 |
co_hall_00180 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HAP1 GENE_ENCODES_PROTEIN HAP1 -> HAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH SORT1 -> SORT1 GENE_ENCODES_PROTEIN SORT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HAP1",
"source_node_type": "GENE",
"source_node_label": "HAP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9001",... | D | [
"A. LEPR interacts with JAK3",
"B. MTOR interacts with FBXW7",
"C. HAP1 interacts with SORT1",
"D. SUPT5H interacts with MECP2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HAP1",
"source_db": "UniProt",
"payload": {
"accession": "P54257",
"sequence": "MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQFLSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIWKTPAA... | [
{
"source_db": "bridge",
"source_id": "9001",
"text": "HAP1 GENE_ENCODES_PROTEIN HAP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6272",
"text": "HAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH SORT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "SUPT5H interacts with MECP2",
"real_options": [
"HAP1 interacts with SORT1",
"MTOR interacts with FBXW7",
"LEPR interacts with JAK3"
]
} | 0.9 |
co_hall_00181 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDKN1A GENE_ENCODES_PROTEIN CDKN1A -> CDKN1A PROTEIN_PHYSICALLY_INTERACTS_WITH MDM4 -> MDM4 GENE_ENCODES_PROTEIN MDM4 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDKN1A",
"source_node_type": "GENE",
"source_node_label": "CDKN1A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10... | D | [
"A. EGFR interacts with SOCS6",
"B. CDKN1A interacts with MDM4",
"C. KLK3 interacts with SERPINA1",
"D. ENSP00000424313 interacts with ENSP00000423413"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN1A",
"source_db": "UniProt",
"payload": {
"accession": "P38936",
"sequence": "MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPG... | [
{
"source_db": "bridge",
"source_id": "1026",
"text": "CDKN1A GENE_ENCODES_PROTEIN CDKN1A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4194",
"text": "CDKN1A PROTEIN_PHYSICALLY_INTERACTS_WITH MDM4",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000424313 interacts with ENSP00000423413",
"real_options": [
"CDKN1A interacts with MDM4",
"KLK3 interacts with SERPINA1",
"EGFR interacts with SOCS6"
]
} | 0.9 |
co_hall_00182 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH CUL1 -> CUL1 GENE_ENCODES_PROTEIN CUL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | A | [
"A. SERPINB9 interacts with UBC_UBE2D4",
"B. VCP interacts with CUL1",
"C. SH3BP2 interacts with CBL",
"D. ESR1 interacts with ZNF131"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8454",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH CUL1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"mode": "interaction",
"fabricated": "SERPINB9 interacts with UBC_UBE2D4",
"real_options": [
"VCP interacts with CUL1",
"SH3BP2 interacts with CBL",
"ESR1 interacts with ZNF131"
]
} | 0.9 |
co_hall_00183 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PARK7 GENE_ENCODES_PROTEIN PARK7 -> PARK7 PROTEIN_PHYSICALLY_INTERACTS_WITH NONO -> NONO GENE_ENCODES_PROTEIN NONO | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK7",
"source_node_type": "GENE",
"source_node_label": "PARK7",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1131... | B | [
"A. XRCC5 interacts with PGR",
"B. RFFL interacts with AP2B1",
"C. VAMP2 interacts with SNCA",
"D. PARK7 interacts with NONO"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PARK7",
"source_db": "UniProt",
"payload": {
"accession": "Q99497",
"sequence": "MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKM... | [
{
"source_db": "bridge",
"source_id": "11315",
"text": "PARK7 GENE_ENCODES_PROTEIN PARK7",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4841",
"text": "PARK7 PROTEIN_PHYSICALLY_INTERACTS_WITH NONO",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "RFFL interacts with AP2B1",
"real_options": [
"PARK7 interacts with NONO",
"XRCC5 interacts with PGR",
"VAMP2 interacts with SNCA"
]
} | 0.9 |
co_hall_00184 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | LRRK2 GENE_ENCODES_PROTEIN LRRK2 -> LRRK2 PROTEIN_PHYSICALLY_INTERACTS_WITH ARHGEF7 -> ARHGEF7 GENE_ENCODES_PROTEIN ARHGEF7 | {
"steps": [
{
"hop": 1,
"source_node_id": "LRRK2",
"source_node_type": "GENE",
"source_node_label": "LRRK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1208... | C | [
"A. SPOP interacts with RGPD3",
"B. C9orf72 interacts with CDC27",
"C. FDFT1 interacts with ENSP00000454703",
"D. LRRK2 interacts with ARHGEF7"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "bridge",
"source_id": "120892",
"text": "LRRK2 GENE_ENCODES_PROTEIN LRRK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8874",
"text": "LRRK2 PROTEIN_PHYSICALLY_INTERACTS_WITH ARHGEF7",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "FDFT1 interacts with ENSP00000454703",
"real_options": [
"LRRK2 interacts with ARHGEF7",
"SPOP interacts with RGPD3",
"C9orf72 interacts with CDC27"
]
} | 0.9 |
co_hall_00185 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH UBTF -> UBTF GENE_ENCODES_PROTEIN UBTF | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | A | [
"A. MRPL11 interacts with ENSP00000349084",
"B. NOTCH1 interacts with LCK",
"C. SMYD3 interacts with ESR1",
"D. SOX2 interacts with UBTF"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7343",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH UBTF",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "MRPL11 interacts with ENSP00000349084",
"real_options": [
"SOX2 interacts with UBTF",
"NOTCH1 interacts with LCK",
"SMYD3 interacts with ESR1"
]
} | 0.9 |
co_hall_00186 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FBXW7 GENE_ENCODES_PROTEIN FBXW7 -> FBXW7 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA -> AURKA GENE_ENCODES_PROTEIN AURKA | {
"steps": [
{
"hop": 1,
"source_node_id": "FBXW7",
"source_node_type": "GENE",
"source_node_label": "FBXW7",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5529... | A | [
"A. KNSTRN interacts with CLOCK",
"B. ZMYM3 interacts with FAM175A",
"C. ALK interacts with PIK3CB",
"D. FBXW7 interacts with AURKA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKA",
"source_db": "UniProt",
"payload": {
"accession": "O14965",
"sequence": "MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDF... | [
{
"source_db": "bridge",
"source_id": "55294",
"text": "FBXW7 GENE_ENCODES_PROTEIN FBXW7",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6790",
"text": "FBXW7 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "KNSTRN interacts with CLOCK",
"real_options": [
"FBXW7 interacts with AURKA",
"ALK interacts with PIK3CB",
"ZMYM3 interacts with FAM175A"
]
} | 0.9 |
co_hall_00187 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | APP GENE_ENCODES_PROTEIN APP -> APP PROTEIN_PHYSICALLY_INTERACTS_WITH MAPRE1 -> MAPRE1 GENE_ENCODES_PROTEIN MAPRE1 | {
"steps": [
{
"hop": 1,
"source_node_id": "APP",
"source_node_type": "GENE",
"source_node_label": "APP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "351",
... | D | [
"A. MYC interacts with LMNA",
"B. APP interacts with MAPRE1",
"C. MAPT interacts with PACSIN1",
"D. H2BC6 interacts with SERPINB8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "bridge",
"source_id": "351",
"text": "APP GENE_ENCODES_PROTEIN APP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "22919",
"text": "APP PROTEIN_PHYSICALLY_INTERACTS_WITH MAPRE1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "H2BC6 interacts with SERPINB8",
"real_options": [
"APP interacts with MAPRE1",
"MYC interacts with LMNA",
"MAPT interacts with PACSIN1"
]
} | 0.9 |
co_hall_00188 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SLC25A5 -> SLC25A5 GENE_ENCODES_PROTEIN SLC25A5 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | A | [
"A. ENSP00000620424 interacts with OGT",
"B. SOX2 interacts with SLC25A5",
"C. SFN interacts with CBL",
"D. PSEN1 interacts with NOS3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "292",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SLC25A5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000620424 interacts with OGT",
"real_options": [
"SOX2 interacts with SLC25A5",
"PSEN1 interacts with NOS3",
"SFN interacts with CBL"
]
} | 0.9 |
co_hall_00189 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PSEN2 GENE_ENCODES_PROTEIN PSEN2 -> PSEN2 PROTEIN_PHYSICALLY_INTERACTS_WITH IFIT5 -> IFIT5 GENE_ENCODES_PROTEIN IFIT5 | {
"steps": [
{
"hop": 1,
"source_node_id": "PSEN2",
"source_node_type": "GENE",
"source_node_label": "PSEN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5664... | D | [
"A. CXCL13 interacts with CDKN1A",
"B. PSEN2 interacts with IFIT5",
"C. BRCA2 interacts with TERT",
"D. TAF3 interacts with AMHR2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSEN2",
"source_db": "UniProt",
"payload": {
"accession": "P49810",
"sequence": "MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQ... | [
{
"source_db": "bridge",
"source_id": "5664",
"text": "PSEN2 GENE_ENCODES_PROTEIN PSEN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "24138",
"text": "PSEN2 PROTEIN_PHYSICALLY_INTERACTS_WITH IFIT5",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "TAF3 interacts with AMHR2",
"real_options": [
"PSEN2 interacts with IFIT5",
"CXCL13 interacts with CDKN1A",
"BRCA2 interacts with TERT"
]
} | 0.9 |
co_hall_00190 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FOXO3 GENE_ENCODES_PROTEIN FOXO3 -> FOXO3 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FOXO3",
"source_node_type": "PROTEIN",
"source_node_label": "FOXO3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2... | A | [
"A. KLF11 interacts with Transcription factor SOX-2",
"B. FOXO3 interacts with CTNNB1",
"C. TMEM173 interacts with MTOR",
"D. SOX2 interacts with THRAP3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "2309",
"text": "FOXO3 GENE_ENCODES_PROTEIN FOXO3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "FOXO3 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "KLF11 interacts with Transcription factor SOX-2",
"real_options": [
"FOXO3 interacts with CTNNB1",
"SOX2 interacts with THRAP3",
"TMEM173 interacts with MTOR"
]
} | 0.9 |
co_hall_00191 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CHEK2 GENE_ENCODES_PROTEIN CHEK2 -> CHEK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R2B -> PPP2R2B GENE_ENCODES_PROTEIN PPP2R2B | {
"steps": [
{
"hop": 1,
"source_node_id": "CHEK2",
"source_node_type": "GENE",
"source_node_label": "CHEK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1120... | D | [
"A. CHEK2 interacts with PPP2R2B",
"B. BRCA1 interacts with SEPT10",
"C. TUBA4A interacts with TUBB2A",
"D. STRIP1 interacts with NEFH"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CHEK2",
"source_db": "UniProt",
"payload": {
"accession": "O96017",
"sequence": "MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRT... | [
{
"source_db": "bridge",
"source_id": "11200",
"text": "CHEK2 GENE_ENCODES_PROTEIN CHEK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5521",
"text": "CHEK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R2B",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "STRIP1 interacts with NEFH",
"real_options": [
"CHEK2 interacts with PPP2R2B",
"TUBA4A interacts with TUBB2A",
"BRCA1 interacts with SEPT10"
]
} | 0.9 |
co_hall_00192 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | NRG1 GENE_ENCODES_PROTEIN NRG1 -> NRG1 PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB4 -> ERBB4 GENE_ENCODES_PROTEIN ERBB4 | {
"steps": [
{
"hop": 1,
"source_node_id": "NRG1",
"source_node_type": "PROTEIN",
"source_node_label": "NRG1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "308... | B | [
"A. UCHL3 interacts with AURKB",
"B. ENSP00000650589 interacts with NRBF2",
"C. ITPR3 interacts with VCP",
"D. NRG1 interacts with ERBB4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB4",
"source_db": "UniProt",
"payload": {
"accession": "Q15303",
"sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQE... | [
{
"source_db": "bridge",
"source_id": "3084",
"text": "NRG1 GENE_ENCODES_PROTEIN NRG1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2066",
"text": "NRG1 PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB4",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "ENSP00000650589 interacts with NRBF2",
"real_options": [
"NRG1 interacts with ERBB4",
"ITPR3 interacts with VCP",
"UCHL3 interacts with AURKB"
]
} | 0.9 |
co_hall_00193 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SKP2 GENE_ENCODES_PROTEIN SKP2 -> SKP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CASP3 -> CASP3 GENE_ENCODES_PROTEIN CASP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "SKP2",
"source_node_type": "GENE",
"source_node_label": "SKP2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6502",... | D | [
"A. MRE11A interacts with CDX2",
"B. SKP2 interacts with CASP3",
"C. TFCP2 interacts with FOXA1",
"D. POLR2G interacts with TRIM33"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP3",
"source_db": "UniProt",
"payload": {
"accession": "P42574",
"sequence": "MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP... | [
{
"source_db": "bridge",
"source_id": "6502",
"text": "SKP2 GENE_ENCODES_PROTEIN SKP2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "836",
"text": "SKP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CASP3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "POLR2G interacts with TRIM33",
"real_options": [
"SKP2 interacts with CASP3",
"MRE11A interacts with CDX2",
"TFCP2 interacts with FOXA1"
]
} | 0.9 |
co_hall_00194 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AGTR1 GENE_ENCODES_PROTEIN AGTR1 -> AGTR1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1 -> MAPK1 GENE_ENCODES_PROTEIN MAPK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AGTR1",
"source_node_type": "PROTEIN",
"source_node_label": "AGTR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1... | C | [
"A. AGTR1 interacts with MAPK1",
"B. C9orf72 interacts with DSTN",
"C. ATF4 interacts with NFYA",
"D. KMT2D interacts with WDR5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "bridge",
"source_id": "185",
"text": "AGTR1 GENE_ENCODES_PROTEIN AGTR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5594",
"text": "AGTR1 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ATF4 interacts with NFYA",
"real_options": [
"AGTR1 interacts with MAPK1",
"KMT2D interacts with WDR5",
"C9orf72 interacts with DSTN"
]
} | 0.9 |
co_hall_00195 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SETD7 GENE_ENCODES_PROTEIN SETD7 -> SETD7 PROTEIN_PHYSICALLY_INTERACTS_WITH SOX2 -> SOX2 GENE_ENCODES_PROTEIN SOX2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SETD7",
"source_node_type": "GENE",
"source_node_label": "SETD7",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8085... | D | [
"A. ATM interacts with MAPK14",
"B. FUS interacts with UPF1",
"C. SETD7 interacts with SOX2",
"D. ENSP00000650581 interacts with ENSP00000734844"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "80854",
"text": "SETD7 GENE_ENCODES_PROTEIN SETD7",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6657",
"text": "SETD7 PROTEIN_PHYSICALLY_INTERACTS_WITH SOX2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "ENSP00000650581 interacts with ENSP00000734844",
"real_options": [
"SETD7 interacts with SOX2",
"ATM interacts with MAPK14",
"FUS interacts with UPF1"
]
} | 0.9 |
co_hall_00196 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDC25B GENE_ENCODES_PROTEIN CDC25B -> CDC25B PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK14 -> MAPK14 GENE_ENCODES_PROTEIN MAPK14 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDC25B",
"source_node_type": "GENE",
"source_node_label": "CDC25B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "99... | C | [
"A. CDC25B interacts with MAPK14",
"B. OPTN interacts with SQSTM1",
"C. SENP3 interacts with ADIPOR1",
"D. POLK interacts with MSH2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDC25B",
"source_db": "UniProt",
"payload": {
"accession": "P30305",
"sequence": "MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAI... | [
{
"source_db": "bridge",
"source_id": "994",
"text": "CDC25B GENE_ENCODES_PROTEIN CDC25B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1432",
"text": "CDC25B PROTEIN_PHYSICALLY_INTERACTS_WITH MAPK14",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"mode": "interaction",
"fabricated": "SENP3 interacts with ADIPOR1",
"real_options": [
"CDC25B interacts with MAPK14",
"OPTN interacts with SQSTM1",
"POLK interacts with MSH2"
]
} | 0.9 |
co_hall_00197 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA5 -> HSPA5 GENE_ENCODES_PROTEIN HSPA5 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | A | [
"A. SF3B6 interacts with RC3H2",
"B. AR interacts with HSPA5",
"C. EGFR interacts with MGARP",
"D. VCP interacts with RPS3A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3309",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "HSP... | {
"mode": "interaction",
"fabricated": "SF3B6 interacts with RC3H2",
"real_options": [
"AR interacts with HSPA5",
"VCP interacts with RPS3A",
"EGFR interacts with MGARP"
]
} | 0.9 |
co_hall_00198 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH NOMO3 -> NOMO3 GENE_ENCODES_PROTEIN NOMO3 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. C9orf72 interacts with NOMO3",
"B. UBQLN2 interacts with ZNF703",
"C. ENSP00000633350 interacts with ENSP00000426034",
"D. ERBB4 interacts with DLG2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "408050",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH NOMO3",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000633350 interacts with ENSP00000426034",
"real_options": [
"C9orf72 interacts with NOMO3",
"ERBB4 interacts with DLG2",
"UBQLN2 interacts with ZNF703"
]
} | 0.9 |
co_hall_00199 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | RXRA GENE_ENCODES_PROTEIN RXRA -> RXRA PROTEIN_PHYSICALLY_INTERACTS_WITH NR1I3 -> NR1I3 GENE_ENCODES_PROTEIN NR1I3 | {
"steps": [
{
"hop": 1,
"source_node_id": "RXRA",
"source_node_type": "GENE",
"source_node_label": "RXRA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6256",... | A | [
"A. EIF2S3 interacts with AIMP1",
"B. NOTCH1 interacts with RBPJ",
"C. APP interacts with NAE1",
"D. RXRA interacts with NR1I3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RXRA",
"source_db": "UniProt",
"payload": {
"accession": "P19793",
"sequence": "MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHI... | [
{
"source_db": "bridge",
"source_id": "6256",
"text": "RXRA GENE_ENCODES_PROTEIN RXRA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9970",
"text": "RXRA PROTEIN_PHYSICALLY_INTERACTS_WITH NR1I3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "EIF2S3 interacts with AIMP1",
"real_options": [
"RXRA interacts with NR1I3",
"APP interacts with NAE1",
"NOTCH1 interacts with RBPJ"
]
} | 0.9 |
co_hall_00200 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | B | [
"A. FOXP2 interacts with TP53",
"B. RPS9 interacts with SH3GL2",
"C. CREBBP interacts with CTNNB1",
"D. NF1 interacts with NSFL1C"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "RPS9 interacts with SH3GL2",
"real_options": [
"CREBBP interacts with CTNNB1",
"NF1 interacts with NSFL1C",
"FOXP2 interacts with TP53"
]
} | 0.9 |
co_hall_00201 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | LGALS3BP GENE_ENCODES_PROTEIN LGALS3BP -> LGALS3BP PROTEIN_PHYSICALLY_INTERACTS_WITH APP -> APP GENE_ENCODES_PROTEIN APP | {
"steps": [
{
"hop": 1,
"source_node_id": "LGALS3BP",
"source_node_type": "GENE",
"source_node_label": "LGALS3BP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | C | [
"A. LGALS3BP interacts with APP",
"B. BANP interacts with ATM",
"C. TMED10 interacts with RNASE3",
"D. TUBA1A interacts with SQSTM1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "bridge",
"source_id": "3959",
"text": "LGALS3BP GENE_ENCODES_PROTEIN LGALS3BP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "351",
"text": "LGALS3BP PROTEIN_PHYSICALLY_INTERACTS_WITH APP",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"mode": "interaction",
"fabricated": "TMED10 interacts with RNASE3",
"real_options": [
"LGALS3BP interacts with APP",
"BANP interacts with ATM",
"TUBA1A interacts with SQSTM1"
]
} | 0.9 |
co_hall_00202 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | FOXP1 GENE_ENCODES_PROTEIN FOXP1 -> FOXP1 PROTEIN_PHYSICALLY_INTERACTS_WITH CD274 -> CD274 GENE_ENCODES_PROTEIN CD274 | {
"steps": [
{
"hop": 1,
"source_node_id": "FOXP1",
"source_node_type": "GENE",
"source_node_label": "FOXP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2708... | D | [
"A. C9orf72 interacts with AZI2",
"B. FOXP1 interacts with CD274",
"C. CA9 interacts with RTCB",
"D. ENSP00000514905 interacts with ENSP00000482733"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD274",
"source_db": "UniProt",
"payload": {
"accession": "Q9NZQ7",
"sequence": "MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAP... | [
{
"source_db": "bridge",
"source_id": "27086",
"text": "FOXP1 GENE_ENCODES_PROTEIN FOXP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29126",
"text": "FOXP1 PROTEIN_PHYSICALLY_INTERACTS_WITH CD274",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000514905 interacts with ENSP00000482733",
"real_options": [
"FOXP1 interacts with CD274",
"C9orf72 interacts with AZI2",
"CA9 interacts with RTCB"
]
} | 0.9 |
co_hall_00203 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CHUK GENE_ENCODES_PROTEIN CHUK -> CHUK PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CHUK",
"source_node_type": "GENE",
"source_node_label": "CHUK",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1147",... | B | [
"A. SQSTM1 interacts with NOD1",
"B. CEP192 interacts with ZFYVE19",
"C. ATXN2 interacts with ITPR1",
"D. CHUK interacts with CTNNB1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "1147",
"text": "CHUK GENE_ENCODES_PROTEIN CHUK",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "CHUK PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "CEP192 interacts with ZFYVE19",
"real_options": [
"CHUK interacts with CTNNB1",
"ATXN2 interacts with ITPR1",
"SQSTM1 interacts with NOD1"
]
} | 0.9 |
co_hall_00204 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH PTOV1 -> PTOV1 GENE_ENCODES_PROTEIN PTOV1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | B | [
"A. EGFR interacts with PPP5C",
"B. ENSP00000602627 interacts with PCNA",
"C. CREBBP interacts with PTOV1",
"D. KIAA0368 interacts with DCTN1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "53635",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH PTOV1",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"mode": "interaction",
"fabricated": "ENSP00000602627 interacts with PCNA",
"real_options": [
"CREBBP interacts with PTOV1",
"EGFR interacts with PPP5C",
"KIAA0368 interacts with DCTN1"
]
} | 0.9 |
co_hall_00205 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29 | {
"steps": [
{
"hop": 1,
"source_node_id": "LRRK2",
"source_node_type": "GENE",
"source_node_label": "LRRK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.995,
"edge_source_db": "STRING",
... | D | [
"A. LRRK2 interacts with RAB29",
"B. C9orf72 interacts with RPL5",
"C. UCHL1 interacts with CDK4",
"D. UBA52_UBE2N interacts with HUWE1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "STRING",
"source_id": "RAB29",
"text": "LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29",
"confidence": 0.995
}
] | {
"mode": "interaction",
"fabricated": "UBA52_UBE2N interacts with HUWE1",
"real_options": [
"LRRK2 interacts with RAB29",
"UCHL1 interacts with CDK4",
"C9orf72 interacts with RPL5"
]
} | 0.995 |
co_hall_00206 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SUPT5H | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK12",
"source_node_type": "GENE",
"source_node_label": "CDK12",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.933,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000514936 interacts with PDE4D",
"B. CDK12 interacts with SUPT5H",
"C. SOX2 interacts with ATP6V1A",
"D. RNF168 interacts with SQSTM1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK12",
"source_db": "UniProt",
"payload": {
"accession": "Q9NYV4",
"sequence": "MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKS... | [
{
"source_db": "STRING",
"source_id": "SUPT5H",
"text": "CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SUPT5H",
"confidence": 0.933
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000514936 interacts with PDE4D",
"real_options": [
"CDK12 interacts with SUPT5H",
"SOX2 interacts with ATP6V1A",
"RNF168 interacts with SQSTM1"
]
} | 0.933 |
co_hall_00207 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BLM GENE_ENCODES_PROTEIN BLM -> BLM PROTEIN_PHYSICALLY_INTERACTS_WITH FANCA -> FANCA GENE_ENCODES_PROTEIN FANCA | {
"steps": [
{
"hop": 1,
"source_node_id": "BLM",
"source_node_type": "GENE",
"source_node_label": "BLM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "641",
... | A | [
"A. ENSP00000650495 interacts with ZC3H12A",
"B. C9orf72 interacts with EBNA1BP2",
"C. TP53 interacts with PPM1D",
"D. BLM interacts with FANCA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BLM",
"source_db": "UniProt",
"payload": {
"accession": "P54132",
"sequence": "MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTA... | [
{
"source_db": "bridge",
"source_id": "641",
"text": "BLM GENE_ENCODES_PROTEIN BLM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2175",
"text": "BLM PROTEIN_PHYSICALLY_INTERACTS_WITH FANCA",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"mode": "interaction",
"fabricated": "ENSP00000650495 interacts with ZC3H12A",
"real_options": [
"BLM interacts with FANCA",
"C9orf72 interacts with EBNA1BP2",
"TP53 interacts with PPM1D"
]
} | 0.9 |
co_hall_00208 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH AAMP -> AAMP GENE_ENCODES_PROTEIN AAMP | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. C9orf72 interacts with AAMP",
"B. UBQLN2 interacts with PSMA7",
"C. SET interacts with ENSP00000396241",
"D. NOS3 interacts with CTNNB1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "14",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH AAMP",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"mode": "interaction",
"fabricated": "SET interacts with ENSP00000396241",
"real_options": [
"C9orf72 interacts with AAMP",
"UBQLN2 interacts with PSMA7",
"NOS3 interacts with CTNNB1"
]
} | 0.9 |
co_hall_00209 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C11orf30 GENE_ENCODES_PROTEIN C11orf30 -> C11orf30 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2 -> BRCA2 GENE_ENCODES_PROTEIN BRCA2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C11orf30",
"source_node_type": "GENE",
"source_node_label": "C11orf30",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | B | [
"A. ESR1 interacts with HOXA10",
"B. ENSP00000576341 interacts with WNT5A",
"C. XRCC5 interacts with ATM",
"D. C11orf30 interacts with BRCA2"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "56946",
"text": "C11orf30 GENE_ENCODES_PROTEIN C11orf30",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "675",
"text": "C11orf30 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "ENSP00000576341 interacts with WNT5A",
"real_options": [
"C11orf30 interacts with BRCA2",
"ESR1 interacts with HOXA10",
"XRCC5 interacts with ATM"
]
} | 0.9 |
co_hall_00210 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EBF1 GENE_ENCODES_PROTEIN EBF1 -> EBF1 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP -> CREBBP GENE_ENCODES_PROTEIN CREBBP | {
"steps": [
{
"hop": 1,
"source_node_id": "EBF1",
"source_node_type": "GENE",
"source_node_label": "EBF1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1879",... | C | [
"A. PLD2 interacts with BIN1",
"B. VCP interacts with ELAVL1",
"C. CHTF18 interacts with SETD1A",
"D. EBF1 interacts with CREBBP"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1879",
"text": "EBF1 GENE_ENCODES_PROTEIN EBF1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1387",
"text": "EBF1 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "CHTF18 interacts with SETD1A",
"real_options": [
"EBF1 interacts with CREBBP",
"PLD2 interacts with BIN1",
"VCP interacts with ELAVL1"
]
} | 0.9 |
co_hall_00211 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EP300 GENE_ENCODES_PROTEIN EP300 -> EP300 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1 -> ESR1 GENE_ENCODES_PROTEIN ESR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "EP300",
"source_node_type": "PROTEIN",
"source_node_label": "EP300",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2... | D | [
"A. CDH1 interacts with NIPSNAP1",
"B. EP300 interacts with ESR1",
"C. SOX2 interacts with ANKHD1",
"D. ENSP00000686652 interacts with NCK1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "2033",
"text": "EP300 GENE_ENCODES_PROTEIN EP300",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2099",
"text": "EP300 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000686652 interacts with NCK1",
"real_options": [
"EP300 interacts with ESR1",
"CDH1 interacts with NIPSNAP1",
"SOX2 interacts with ANKHD1"
]
} | 0.9 |
co_hall_00212 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | UBE2K GENE_ENCODES_PROTEIN UBE2K -> UBE2K PROTEIN_PHYSICALLY_INTERACTS_WITH HTT -> HTT GENE_ENCODES_PROTEIN HTT | {
"steps": [
{
"hop": 1,
"source_node_id": "UBE2K",
"source_node_type": "GENE",
"source_node_label": "UBE2K",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3093... | C | [
"A. CDX2 interacts with GATA6",
"B. FGFR1 interacts with VAV1",
"C. ENSP00000537151 interacts with CKMT1B",
"D. UBE2K interacts with HTT"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HTT",
"source_db": "UniProt",
"payload": {
"accession": "P42858",
"sequence": "MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLC... | [
{
"source_db": "bridge",
"source_id": "3093",
"text": "UBE2K GENE_ENCODES_PROTEIN UBE2K",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3064",
"text": "UBE2K PROTEIN_PHYSICALLY_INTERACTS_WITH HTT",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "ENSP00000537151 interacts with CKMT1B",
"real_options": [
"UBE2K interacts with HTT",
"CDX2 interacts with GATA6",
"FGFR1 interacts with VAV1"
]
} | 0.9 |
co_hall_00213 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HSP90AA1 GENE_ENCODES_PROTEIN HSP90AA1 -> HSP90AA1 PROTEIN_PHYSICALLY_INTERACTS_WITH ABL1 -> ABL1 GENE_ENCODES_PROTEIN ABL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HSP90AA1",
"source_node_type": "PROTEIN",
"source_node_label": "HSP90AA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_i... | B | [
"A. VCP interacts with FBXL19",
"B. ENSP00000472411 interacts with ZBTB7A",
"C. HSP90AA1 interacts with ABL1",
"D. BIRC5 interacts with CASP3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "bridge",
"source_id": "3320",
"text": "HSP90AA1 GENE_ENCODES_PROTEIN HSP90AA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "25",
"text": "HSP90AA1 PROTEIN_PHYSICALLY_INTERACTS_WITH ABL1",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"mode": "interaction",
"fabricated": "ENSP00000472411 interacts with ZBTB7A",
"real_options": [
"HSP90AA1 interacts with ABL1",
"BIRC5 interacts with CASP3",
"VCP interacts with FBXL19"
]
} | 0.9 |
co_hall_00214 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | DCTN1 GENE_ENCODES_PROTEIN DCTN1 -> DCTN1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTIF -> CTIF GENE_ENCODES_PROTEIN CTIF | {
"steps": [
{
"hop": 1,
"source_node_id": "DCTN1",
"source_node_type": "GENE",
"source_node_label": "DCTN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1639... | C | [
"A. PSEN1 interacts with PSEN1",
"B. DCTN1 interacts with CTIF",
"C. OGG1 interacts with KCNB1",
"D. CUL7 interacts with TP53"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DCTN1",
"source_db": "UniProt",
"payload": {
"accession": "Q14203",
"sequence": "MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRG... | [
{
"source_db": "bridge",
"source_id": "1639",
"text": "DCTN1 GENE_ENCODES_PROTEIN DCTN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9811",
"text": "DCTN1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTIF",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "OGG1 interacts with KCNB1",
"real_options": [
"DCTN1 interacts with CTIF",
"PSEN1 interacts with PSEN1",
"CUL7 interacts with TP53"
]
} | 0.9 |
co_hall_00215 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH XRCC6 -> XRCC6 GENE_ENCODES_PROTEIN XRCC6 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "983",
... | C | [
"A. C9orf72 interacts with CAMK2B",
"B. C9orf72 interacts with SLC25A1",
"C. SOGA1 interacts with INCENP",
"D. CDK1 interacts with XRCC6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "983",
"text": "CDK1 GENE_ENCODES_PROTEIN CDK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2547",
"text": "CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH XRCC6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "SOGA1 interacts with INCENP",
"real_options": [
"CDK1 interacts with XRCC6",
"C9orf72 interacts with CAMK2B",
"C9orf72 interacts with SLC25A1"
]
} | 0.9 |
co_hall_00216 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 -> CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH FHIT -> FHIT GENE_ENCODES_PROTEIN FHIT | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | B | [
"A. CTNNB1 interacts with FHIT",
"B. ENSP00000324180 interacts with TLR2",
"C. TNIP1 interacts with VCP",
"D. CASP3 interacts with CASP3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "1499",
"text": "CTNNB1 GENE_ENCODES_PROTEIN CTNNB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2272",
"text": "CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH FHIT",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "ENSP00000324180 interacts with TLR2",
"real_options": [
"CTNNB1 interacts with FHIT",
"TNIP1 interacts with VCP",
"CASP3 interacts with CASP3"
]
} | 0.9 |
co_hall_00217 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH IDH1 -> IDH1 GENE_ENCODES_PROTEIN IDH1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | B | [
"A. APP interacts with GRIN2B",
"B. HMGCR interacts with KLC3",
"C. APOE interacts with LRP1",
"D. SOX2 interacts with IDH1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3417",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH IDH1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "HMGCR interacts with KLC3",
"real_options": [
"SOX2 interacts with IDH1",
"APOE interacts with LRP1",
"APP interacts with GRIN2B"
]
} | 0.9 |
co_hall_00218 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PPARGC1A GENE_ENCODES_PROTEIN PPARGC1A -> PPARGC1A PROTEIN_PHYSICALLY_INTERACTS_WITH RXRA -> RXRA GENE_ENCODES_PROTEIN RXRA | {
"steps": [
{
"hop": 1,
"source_node_id": "PPARGC1A",
"source_node_type": "GENE",
"source_node_label": "PPARGC1A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | C | [
"A. PPARGC1A interacts with RXRA",
"B. ANXA11 interacts with PDCD6",
"C. CASP12 interacts with JAG1",
"D. SPOP interacts with HSPA8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RXRA",
"source_db": "UniProt",
"payload": {
"accession": "P19793",
"sequence": "MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHI... | [
{
"source_db": "bridge",
"source_id": "10891",
"text": "PPARGC1A GENE_ENCODES_PROTEIN PPARGC1A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6256",
"text": "PPARGC1A PROTEIN_PHYSICALLY_INTERACTS_WITH RXRA",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "CASP12 interacts with JAG1",
"real_options": [
"PPARGC1A interacts with RXRA",
"ANXA11 interacts with PDCD6",
"SPOP interacts with HSPA8"
]
} | 0.9 |
co_hall_00219 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PRKN | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK7",
"source_node_type": "GENE",
"source_node_label": "PARK7",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. PARK7 interacts with PRKN",
"B. SEC24C interacts with TSC22D3",
"C. BARD1 interacts with UBE2E2",
"D. PIK3C2B interacts with EGFR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PARK7",
"source_db": "UniProt",
"payload": {
"accession": "Q99497",
"sequence": "MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKM... | [
{
"source_db": "STRING",
"source_id": "PRKN",
"text": "PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PRKN",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "SEC24C interacts with TSC22D3",
"real_options": [
"PARK7 interacts with PRKN",
"BARD1 interacts with UBE2E2",
"PIK3C2B interacts with EGFR"
]
} | 0.999 |
co_hall_00220 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP | {
"steps": [
{
"hop": 1,
"source_node_id": "AVPR1A",
"source_node_type": "GENE",
"source_node_label": "AVPR1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. ENSP00000542117 interacts with SNAI2",
"B. AKT1 interacts with GATA2",
"C. HTT interacts with MID1",
"D. AVPR1A interacts with AVP"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AVPR1A",
"source_db": "UniProt",
"payload": {
"accession": "P37288",
"sequence": "MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQV... | [
{
"source_db": "STRING",
"source_id": "AVP",
"text": "AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000542117 interacts with SNAI2",
"real_options": [
"AVPR1A interacts with AVP",
"HTT interacts with MID1",
"AKT1 interacts with GATA2"
]
} | 0.999 |
co_hall_00221 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EXD2 -> EXD2 GENE_ENCODES_PROTEIN EXD2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | C | [
"A. TBK1 interacts with RUVBL2",
"B. BRCA1 interacts with POT1",
"C. LILRB2 interacts with MCM7",
"D. C9orf72 interacts with EXD2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "55218",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EXD2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "LILRB2 interacts with MCM7",
"real_options": [
"C9orf72 interacts with EXD2",
"TBK1 interacts with RUVBL2",
"BRCA1 interacts with POT1"
]
} | 0.9 |
co_hall_00222 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH UPF1 -> UPF1 GENE_ENCODES_PROTEIN UPF1 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | A | [
"A. SCRIB interacts with RAPGEF1",
"B. C9orf72 interacts with UPF1",
"C. C9orf72 interacts with COPS5",
"D. VCP interacts with GGH"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5976",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH UPF1",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "SCRIB interacts with RAPGEF1",
"real_options": [
"C9orf72 interacts with UPF1",
"C9orf72 interacts with COPS5",
"VCP interacts with GGH"
]
} | 0.9 |
co_hall_00223 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HDAC3 GENE_ENCODES_PROTEIN HDAC3 -> HDAC3 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1 -> ESR1 GENE_ENCODES_PROTEIN ESR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HDAC3",
"source_node_type": "GENE",
"source_node_label": "HDAC3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8841... | B | [
"A. FBXL5 interacts with DCTN1",
"B. ENSP00000425957 interacts with TSPAN33",
"C. ERG interacts with XRCC5",
"D. HDAC3 interacts with ESR1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "8841",
"text": "HDAC3 GENE_ENCODES_PROTEIN HDAC3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2099",
"text": "HDAC3 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000425957 interacts with TSPAN33",
"real_options": [
"HDAC3 interacts with ESR1",
"ERG interacts with XRCC5",
"FBXL5 interacts with DCTN1"
]
} | 0.9 |
co_hall_00224 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | APP GENE_ENCODES_PROTEIN APP -> APP PROTEIN_PHYSICALLY_INTERACTS_WITH MAP2K6 -> MAP2K6 GENE_ENCODES_PROTEIN MAP2K6 | {
"steps": [
{
"hop": 1,
"source_node_id": "APP",
"source_node_type": "GENE",
"source_node_label": "APP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "351",
... | B | [
"A. ESR1 interacts with PRDX2",
"B. HIST2H2AC interacts with XPO4",
"C. APP interacts with MAP2K6",
"D. PPP2R1B interacts with STRN3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "bridge",
"source_id": "351",
"text": "APP GENE_ENCODES_PROTEIN APP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5608",
"text": "APP PROTEIN_PHYSICALLY_INTERACTS_WITH MAP2K6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"mode": "interaction",
"fabricated": "HIST2H2AC interacts with XPO4",
"real_options": [
"APP interacts with MAP2K6",
"PPP2R1B interacts with STRN3",
"ESR1 interacts with PRDX2"
]
} | 0.9 |
co_hall_00225 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | PSMB2 GENE_ENCODES_PROTEIN PSMB2 -> PSMB2 PROTEIN_PHYSICALLY_INTERACTS_WITH UBQLN2 -> UBQLN2 GENE_ENCODES_PROTEIN UBQLN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "PSMB2",
"source_node_type": "PROTEIN",
"source_node_label": "PSMB2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5... | D | [
"A. RAD50 interacts with MLH1",
"B. PSMB2 interacts with UBQLN2",
"C. BST1 interacts with NNMT",
"D. CASP8 interacts with PTPRO"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "bridge",
"source_id": "5690",
"text": "PSMB2 GENE_ENCODES_PROTEIN PSMB2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29978",
"text": "PSMB2 PROTEIN_PHYSICALLY_INTERACTS_WITH UBQLN2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "CASP8 interacts with PTPRO",
"real_options": [
"PSMB2 interacts with UBQLN2",
"RAD50 interacts with MLH1",
"BST1 interacts with NNMT"
]
} | 0.9 |
co_hall_00226 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | SPOP GENE_ENCODES_PROTEIN SPOP -> SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH PRDX3 -> PRDX3 GENE_ENCODES_PROTEIN PRDX3 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPOP",
"source_node_type": "GENE",
"source_node_label": "SPOP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8405",... | A | [
"A. FANCC interacts with SPOP",
"B. CLTA interacts with VCP",
"C. SQSTM1 interacts with SNCA",
"D. SPOP interacts with PRDX3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "8405",
"text": "SPOP GENE_ENCODES_PROTEIN SPOP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10935",
"text": "SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH PRDX3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "FANCC interacts with SPOP",
"real_options": [
"SPOP interacts with PRDX3",
"CLTA interacts with VCP",
"SQSTM1 interacts with SNCA"
]
} | 0.9 |
co_hall_00227 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH NTRK2 -> NTRK2 GENE_ENCODES_PROTEIN NTRK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | B | [
"A. EGFR interacts with NTRK2",
"B. NSL1 interacts with ENSP00000691153",
"C. RNF31 interacts with PTEN",
"D. C9orf72 interacts with TRIM28"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4915",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH NTRK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"mode": "interaction",
"fabricated": "NSL1 interacts with ENSP00000691153",
"real_options": [
"EGFR interacts with NTRK2",
"C9orf72 interacts with TRIM28",
"RNF31 interacts with PTEN"
]
} | 0.9 |
co_hall_00228 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | HTT GENE_ENCODES_PROTEIN HTT -> HTT PROTEIN_PHYSICALLY_INTERACTS_WITH MAP1LC3A -> MAP1LC3A GENE_ENCODES_PROTEIN MAP1LC3A | {
"steps": [
{
"hop": 1,
"source_node_id": "HTT",
"source_node_type": "GENE",
"source_node_label": "HTT",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3064",
... | A | [
"A. NLRC4 interacts with MAP2K1",
"B. HTT interacts with MAP1LC3A",
"C. NDFIP1 interacts with SNCA",
"D. UBQLN2 interacts with HGS"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HTT",
"source_db": "UniProt",
"payload": {
"accession": "P42858",
"sequence": "MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLC... | [
{
"source_db": "bridge",
"source_id": "3064",
"text": "HTT GENE_ENCODES_PROTEIN HTT",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "84557",
"text": "HTT PROTEIN_PHYSICALLY_INTERACTS_WITH MAP1LC3A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "NLRC4 interacts with MAP2K1",
"real_options": [
"HTT interacts with MAP1LC3A",
"NDFIP1 interacts with SNCA",
"UBQLN2 interacts with HGS"
]
} | 0.9 |
co_hall_00229 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TIA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ELAVL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TIA1",
"source_node_type": "GENE",
"source_node_label": "TIA1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.975,
"edge_source_db": "STRING",
"t... | B | [
"A. TIA1 interacts with ELAVL1",
"B. ENSP00000588365 interacts with CHUK",
"C. SQSTM1 interacts with EGLN3",
"D. ATRX interacts with AKT1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TIA1",
"source_db": "UniProt",
"payload": {
"accession": "P31483",
"sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISD... | [
{
"source_db": "STRING",
"source_id": "ELAVL1",
"text": "TIA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ELAVL1",
"confidence": 0.975
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000588365 interacts with CHUK",
"real_options": [
"TIA1 interacts with ELAVL1",
"ATRX interacts with AKT1",
"SQSTM1 interacts with EGLN3"
]
} | 0.975 |
co_hall_00230 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | BAX GENE_ENCODES_PROTEIN BAX -> BAX PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2L12 -> BCL2L12 GENE_ENCODES_PROTEIN BCL2L12 | {
"steps": [
{
"hop": 1,
"source_node_id": "BAX",
"source_node_type": "GENE",
"source_node_label": "BAX",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "581",
... | D | [
"A. VCP interacts with DERL1",
"B. C9orf72 interacts with AIFM1",
"C. BAX interacts with BCL2L12",
"D. SAAL1 interacts with NLK"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BAX",
"source_db": "UniProt",
"payload": {
"accession": "Q07812",
"sequence": "MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRT... | [
{
"source_db": "bridge",
"source_id": "581",
"text": "BAX GENE_ENCODES_PROTEIN BAX",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "83596",
"text": "BAX PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2L12",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"mode": "interaction",
"fabricated": "SAAL1 interacts with NLK",
"real_options": [
"BAX interacts with BCL2L12",
"VCP interacts with DERL1",
"C9orf72 interacts with AIFM1"
]
} | 0.9 |
co_hall_00231 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AXL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PLCG1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AXL",
"source_node_type": "GENE",
"source_node_label": "AXL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.937,
"edge_source_db": "STRING",
"tar... | C | [
"A. AXL interacts with PLCG1",
"B. AFDN interacts with NECTIN2",
"C. YY1 interacts with CEBPB",
"D. LYN interacts with CDK1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AXL",
"source_db": "UniProt",
"payload": {
"accession": "P30530",
"sequence": "MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGL... | [
{
"source_db": "STRING",
"source_id": "PLCG1",
"text": "AXL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PLCG1",
"confidence": 0.937
}
] | {
"mode": "interaction",
"fabricated": "YY1 interacts with CEBPB",
"real_options": [
"AXL interacts with PLCG1",
"LYN interacts with CDK1",
"AFDN interacts with NECTIN2"
]
} | 0.937 |
co_hall_00232 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AGO4 GENE_ENCODES_PROTEIN AGO4 -> AGO4 PROTEIN_PHYSICALLY_INTERACTS_WITH DNMT3A -> DNMT3A GENE_ENCODES_PROTEIN DNMT3A | {
"steps": [
{
"hop": 1,
"source_node_id": "AGO4",
"source_node_type": "PROTEIN",
"source_node_label": "AGO4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "192... | D | [
"A. BRCA1 interacts with RPAP2",
"B. TP53 interacts with RBCK1",
"C. AGO4 interacts with DNMT3A",
"D. PIP5K1C interacts with GCOM1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DNMT3A",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y6K1",
"sequence": "MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAV... | [
{
"source_db": "bridge",
"source_id": "192670",
"text": "AGO4 GENE_ENCODES_PROTEIN AGO4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1788",
"text": "AGO4 PROTEIN_PHYSICALLY_INTERACTS_WITH DNMT3A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"mode": "interaction",
"fabricated": "PIP5K1C interacts with GCOM1",
"real_options": [
"AGO4 interacts with DNMT3A",
"BRCA1 interacts with RPAP2",
"TP53 interacts with RBCK1"
]
} | 0.9 |
co_hall_00233 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CRYAB GENE_ENCODES_PROTEIN CRYAB -> CRYAB PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "CRYAB",
"source_node_type": "GENE",
"source_node_label": "CRYAB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1410... | A | [
"A. ENSP00000780994 interacts with MYT1L",
"B. CRYAB interacts with TP53",
"C. PDE10A interacts with HPRT1",
"D. HUWE1 interacts with CDKN2A"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "1410",
"text": "CRYAB GENE_ENCODES_PROTEIN CRYAB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "CRYAB PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "ENSP00000780994 interacts with MYT1L",
"real_options": [
"CRYAB interacts with TP53",
"PDE10A interacts with HPRT1",
"HUWE1 interacts with CDKN2A"
]
} | 0.9 |
co_hall_00234 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | RRM2B GENE_ENCODES_PROTEIN RRM2B -> RRM2B PROTEIN_PHYSICALLY_INTERACTS_WITH ATM -> ATM GENE_ENCODES_PROTEIN ATM | {
"steps": [
{
"hop": 1,
"source_node_id": "RRM2B",
"source_node_type": "GENE",
"source_node_label": "RRM2B",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5048... | B | [
"A. AR interacts with BRCA1",
"B. HIST1H1E interacts with KRAS",
"C. RRM2B interacts with ATM",
"D. FUS interacts with UPF3A"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATM",
"source_db": "UniProt",
"payload": {
"accession": "Q13315",
"sequence": "MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGA... | [
{
"source_db": "bridge",
"source_id": "50484",
"text": "RRM2B GENE_ENCODES_PROTEIN RRM2B",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "472",
"text": "RRM2B PROTEIN_PHYSICALLY_INTERACTS_WITH ATM",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"mode": "interaction",
"fabricated": "HIST1H1E interacts with KRAS",
"real_options": [
"RRM2B interacts with ATM",
"FUS interacts with UPF3A",
"AR interacts with BRCA1"
]
} | 0.9 |
co_hall_00235 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CDKN2A GENE_ENCODES_PROTEIN CDKN2A -> CDKN2A PROTEIN_PHYSICALLY_INTERACTS_WITH NMI -> NMI GENE_ENCODES_PROTEIN NMI | {
"steps": [
{
"hop": 1,
"source_node_id": "CDKN2A",
"source_node_type": "GENE",
"source_node_label": "CDKN2A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10... | C | [
"A. CDKN2A interacts with NMI",
"B. SQSTM1 interacts with IRGM",
"C. STAT1 interacts with POLR2K",
"D. SPOP interacts with LOC102724023"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN2A",
"source_db": "UniProt",
"payload": {
"accession": "Q8N726",
"sequence": "MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG... | [
{
"source_db": "bridge",
"source_id": "1029",
"text": "CDKN2A GENE_ENCODES_PROTEIN CDKN2A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9111",
"text": "CDKN2A PROTEIN_PHYSICALLY_INTERACTS_WITH NMI",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "STAT1 interacts with POLR2K",
"real_options": [
"CDKN2A interacts with NMI",
"SQSTM1 interacts with IRGM",
"SPOP interacts with LOC102724023"
]
} | 0.9 |
co_hall_00236 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH DAPK3 -> DAPK3 GENE_ENCODES_PROTEIN DAPK3 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | A | [
"A. ENSP00000519148 interacts with ATG9A",
"B. TP53 interacts with PATZ1",
"C. AR interacts with DAPK3",
"D. UBQLN2 interacts with SRA1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1613",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH DAPK3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "DAP... | {
"mode": "interaction",
"fabricated": "ENSP00000519148 interacts with ATG9A",
"real_options": [
"AR interacts with DAPK3",
"TP53 interacts with PATZ1",
"UBQLN2 interacts with SRA1"
]
} | 0.9 |
co_hall_00237 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA9 -> HSPA9 GENE_ENCODES_PROTEIN HSPA9 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | A | [
"A. SIVA1 interacts with ENSP00000414303",
"B. ATM interacts with TP53",
"C. REST interacts with ALYREF",
"D. C9orf72 interacts with HSPA9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3313",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA9",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "SIVA1 interacts with ENSP00000414303",
"real_options": [
"C9orf72 interacts with HSPA9",
"REST interacts with ALYREF",
"ATM interacts with TP53"
]
} | 0.9 |
co_hall_00238 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CTNNA1 GENE_ENCODES_PROTEIN CTNNA1 -> CTNNA1 PROTEIN_PHYSICALLY_INTERACTS_WITH TJP2 -> TJP2 GENE_ENCODES_PROTEIN TJP2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNA1",
"source_node_type": "GENE",
"source_node_label": "CTNNA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | C | [
"A. CTNNA1 interacts with TJP2",
"B. MAPT interacts with YWHAE",
"C. NSUN2 interacts with ENSP00000717623",
"D. CRYAB interacts with BCL2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "bridge",
"source_id": "1495",
"text": "CTNNA1 GENE_ENCODES_PROTEIN CTNNA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9414",
"text": "CTNNA1 PROTEIN_PHYSICALLY_INTERACTS_WITH TJP2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"mode": "interaction",
"fabricated": "NSUN2 interacts with ENSP00000717623",
"real_options": [
"CTNNA1 interacts with TJP2",
"CRYAB interacts with BCL2",
"MAPT interacts with YWHAE"
]
} | 0.9 |
co_hall_00239 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | ALK GENE_ENCODES_PROTEIN ALK -> ALK PROTEIN_PHYSICALLY_INTERACTS_WITH IRF7 -> IRF7 GENE_ENCODES_PROTEIN IRF7 | {
"steps": [
{
"hop": 1,
"source_node_id": "ALK",
"source_node_type": "GENE",
"source_node_label": "ALK",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "238",
... | B | [
"A. ALK interacts with IRF7",
"B. TIFA interacts with TLK1",
"C. DNMT3A interacts with SIM1",
"D. APP interacts with SPTA1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ALK",
"source_db": "UniProt",
"payload": {
"accession": "Q9UM73",
"sequence": "MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKL... | [
{
"source_db": "bridge",
"source_id": "238",
"text": "ALK GENE_ENCODES_PROTEIN ALK",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3665",
"text": "ALK PROTEIN_PHYSICALLY_INTERACTS_WITH IRF7",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "I... | {
"mode": "interaction",
"fabricated": "TIFA interacts with TLK1",
"real_options": [
"ALK interacts with IRF7",
"APP interacts with SPTA1",
"DNMT3A interacts with SIM1"
]
} | 0.9 |
co_hall_00240 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AJUBA GENE_ENCODES_PROTEIN AJUBA -> AJUBA PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA -> AURKA GENE_ENCODES_PROTEIN AURKA | {
"steps": [
{
"hop": 1,
"source_node_id": "AJUBA",
"source_node_type": "GENE",
"source_node_label": "AJUBA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8496... | C | [
"A. UBQLN2 interacts with HNRNPH3",
"B. BRAF interacts with PSME3",
"C. TCL1B interacts with MAPK8IP2",
"D. AJUBA interacts with AURKA"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKA",
"source_db": "UniProt",
"payload": {
"accession": "O14965",
"sequence": "MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDF... | [
{
"source_db": "bridge",
"source_id": "84962",
"text": "AJUBA GENE_ENCODES_PROTEIN AJUBA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6790",
"text": "AJUBA PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"mode": "interaction",
"fabricated": "TCL1B interacts with MAPK8IP2",
"real_options": [
"AJUBA interacts with AURKA",
"UBQLN2 interacts with HNRNPH3",
"BRAF interacts with PSME3"
]
} | 0.9 |
co_hall_00241 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TBC1D15 -> TBC1D15 GENE_ENCODES_PROTEIN TBC1D15 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | B | [
"A. C9orf72 interacts with TBC1D15",
"B. SSB interacts with ARAP3",
"C. C9orf72 interacts with ALDH3A2",
"D. PPARG interacts with EGFR"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "64786",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TBC1D15",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"mode": "interaction",
"fabricated": "SSB interacts with ARAP3",
"real_options": [
"C9orf72 interacts with TBC1D15",
"C9orf72 interacts with ALDH3A2",
"PPARG interacts with EGFR"
]
} | 0.9 |
co_hall_00242 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | IGSF1 GENE_ENCODES_PROTEIN IGSF1 -> IGSF1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1B -> ACVR1B GENE_ENCODES_PROTEIN ACVR1B | {
"steps": [
{
"hop": 1,
"source_node_id": "IGSF1",
"source_node_type": "GENE",
"source_node_label": "IGSF1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3547... | A | [
"A. TRIM29 interacts with PRKCA",
"B. KMT2D interacts with RBBP5",
"C. IGSF1 interacts with ACVR1B",
"D. ACE interacts with MYH9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1B",
"source_db": "UniProt",
"payload": {
"accession": "P36896",
"sequence": "MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIA... | [
{
"source_db": "bridge",
"source_id": "3547",
"text": "IGSF1 GENE_ENCODES_PROTEIN IGSF1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "91",
"text": "IGSF1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"mode": "interaction",
"fabricated": "TRIM29 interacts with PRKCA",
"real_options": [
"IGSF1 interacts with ACVR1B",
"KMT2D interacts with RBBP5",
"ACE interacts with MYH9"
]
} | 0.9 |
co_hall_00243 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH CCND1 -> CCND1 GENE_ENCODES_PROTEIN CCND1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | D | [
"A. HSP90AB1 interacts with ESR1",
"B. AR interacts with CCND1",
"C. XIAP interacts with BIRC5",
"D. ENSP00000802873 interacts with ENSP00000548176"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "595",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH CCND1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "CCND... | {
"mode": "interaction",
"fabricated": "ENSP00000802873 interacts with ENSP00000548176",
"real_options": [
"AR interacts with CCND1",
"HSP90AB1 interacts with ESR1",
"XIAP interacts with BIRC5"
]
} | 0.9 |
co_hall_00244 | hallucination_detection | coding_variant | easy | 1 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | TP53 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSP90AA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. FGFR1 interacts with RPS6KA1",
"B. TP53 interacts with HSP90AA1",
"C. HUWE1 interacts with MSH2",
"D. ENSP00000457375 interacts with ENSP00000783626"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "STRING",
"source_id": "HSP90AA1",
"text": "TP53 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSP90AA1",
"confidence": 0.999
}
] | {
"mode": "interaction",
"fabricated": "ENSP00000457375 interacts with ENSP00000783626",
"real_options": [
"TP53 interacts with HSP90AA1",
"FGFR1 interacts with RPS6KA1",
"HUWE1 interacts with MSH2"
]
} | 0.999 |
co_hall_00245 | hallucination_detection | coding_variant | medium | 3 | One of the following protein interactions is NOT supported by any entry in BioGRID or STRING. Which one is fabricated? | CAV2 GENE_ENCODES_PROTEIN CAV2 -> CAV2 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR -> EGFR GENE_ENCODES_PROTEIN EGFR | {
"steps": [
{
"hop": 1,
"source_node_id": "CAV2",
"source_node_type": "GENE",
"source_node_label": "CAV2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "858",
... | C | [
"A. CAV2 interacts with EGFR",
"B. APP interacts with TMEM30A",
"C. IFNAR1 interacts with RUNX1T1",
"D. PPP2CA interacts with MYC"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "858",
"text": "CAV2 GENE_ENCODES_PROTEIN CAV2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1956",
"text": "CAV2 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"mode": "interaction",
"fabricated": "IFNAR1 interacts with RUNX1T1",
"real_options": [
"CAV2 interacts with EGFR",
"PPP2CA interacts with MYC",
"APP interacts with TMEM30A"
]
} | 0.9 |
co_inte_00000 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ALB have with a combined association score ≥ 700? | ALB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGRT | {
"steps": [
{
"hop": 1,
"source_node_id": "ALB",
"source_node_type": "GENE",
"source_node_label": "ALB",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | A | [
"A. 10",
"B. 9",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ALB",
"source_db": "UniProt",
"payload": {
"accession": "P02768",
"sequence": "MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPN... | [
{
"source_db": "STRING",
"source_id": "FCGRT",
"text": "ALB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGRT",
"confidence": 0.999
}
] | {
"protein": "ALB",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00001 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD68 have with a combined association score ≥ 900? | CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD68",
"source_node_type": "GENE",
"source_node_label": "CD68",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.922,
"edge_source_db": "STRING",
"t... | B | [
"A. 7",
"B. 6",
"C. 5",
"D. 4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD68",
"source_db": "UniProt",
"payload": {
"accession": "P34810",
"sequence": "MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGF... | [
{
"source_db": "STRING",
"source_id": "LAMP3",
"text": "CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3",
"confidence": 0.922
}
] | {
"protein": "CD68",
"threshold": 900,
"partner_count": 6
} | 0.922 |
co_inte_00002 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FIG4 have with a combined association score ≥ 400? | FIG4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIKFYVE | {
"steps": [
{
"hop": 1,
"source_node_id": "FIG4",
"source_node_type": "GENE",
"source_node_label": "FIG4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FIG4",
"source_db": "UniProt",
"payload": {
"accession": "Q92562",
"sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIY... | [
{
"source_db": "STRING",
"source_id": "PIKFYVE",
"text": "FIG4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIKFYVE",
"confidence": 0.999
}
] | {
"protein": "FIG4",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00003 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does EGFR have with a combined association score ≥ 400? | EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "STRING",
"source_id": "PTPN11",
"text": "EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11",
"confidence": 0.999
}
] | {
"protein": "EGFR",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00004 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does JAK2 have with a combined association score ≥ 400? | JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "JAK2",
"source_node_type": "GENE",
"source_node_label": "JAK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "STRING",
"source_id": "STAT1",
"text": "JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1",
"confidence": 0.999
}
] | {
"protein": "JAK2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00005 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BRCA2 have with a combined association score ≥ 700? | BRCA2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SEM1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA2",
"source_node_type": "GENE",
"source_node_label": "BRCA2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "STRING",
"source_id": "SEM1",
"text": "BRCA2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SEM1",
"confidence": 0.999
}
] | {
"protein": "BRCA2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00006 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDX2 have with a combined association score ≥ 900? | CDX2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KRT20 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDX2",
"source_node_type": "GENE",
"source_node_label": "CDX2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.924,
"edge_source_db": "STRING",
"t... | D | [
"A. 1",
"B. 4",
"C. 2",
"D. 3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDX2",
"source_db": "UniProt",
"payload": {
"accession": "Q99626",
"sequence": "MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCAS... | [
{
"source_db": "STRING",
"source_id": "KRT20",
"text": "CDX2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KRT20",
"confidence": 0.924
}
] | {
"protein": "CDX2",
"threshold": 900,
"partner_count": 3
} | 0.924 |
co_inte_00007 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CCND1 have with a combined association score ≥ 400? | CCND1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CCND1",
"source_node_type": "GENE",
"source_node_label": "CCND1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CCND1",
"source_db": "UniProt",
"payload": {
"accession": "P24385",
"sequence": "MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIR... | [
{
"source_db": "STRING",
"source_id": "CDK2",
"text": "CCND1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK2",
"confidence": 0.999
}
] | {
"protein": "CCND1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00008 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does IL17A have with a combined association score ≥ 900? | IL17A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IL17RA | {
"steps": [
{
"hop": 1,
"source_node_id": "IL17A",
"source_node_type": "GENE",
"source_node_label": "IL17A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "IL17A",
"source_db": "UniProt",
"payload": {
"accession": "Q16552",
"sequence": "MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSF... | [
{
"source_db": "STRING",
"source_id": "IL17RA",
"text": "IL17A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IL17RA",
"confidence": 0.999
}
] | {
"protein": "IL17A",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00009 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CCND1 have with a combined association score ≥ 900? | CCND1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CCND1",
"source_node_type": "GENE",
"source_node_label": "CCND1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 8",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CCND1",
"source_db": "UniProt",
"payload": {
"accession": "P24385",
"sequence": "MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIR... | [
{
"source_db": "STRING",
"source_id": "CDK2",
"text": "CCND1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK2",
"confidence": 0.999
}
] | {
"protein": "CCND1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00010 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MAPT have with a combined association score ≥ 700? | MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5 | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPT",
"source_node_type": "GENE",
"source_node_label": "MAPT",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPT",
"source_db": "UniProt",
"payload": {
"accession": "P10636",
"sequence": "MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQE... | [
{
"source_db": "STRING",
"source_id": "CDK5",
"text": "MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5",
"confidence": 0.999
}
] | {
"protein": "MAPT",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00011 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ABL1 have with a combined association score ≥ 900? | ABL1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GRB2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABL1",
"source_node_type": "GENE",
"source_node_label": "ABL1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "STRING",
"source_id": "GRB2",
"text": "ABL1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GRB2",
"confidence": 0.999
}
] | {
"protein": "ABL1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00012 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD33 have with a combined association score ≥ 900? | CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A | {
"steps": [
{
"hop": 1,
"source_node_id": "CD33",
"source_node_type": "GENE",
"source_node_label": "CD33",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.974,
"edge_source_db": "STRING",
"t... | C | [
"A. 4",
"B. 3",
"C. 5",
"D. 6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD33",
"source_db": "UniProt",
"payload": {
"accession": "P20138",
"sequence": "MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQL... | [
{
"source_db": "STRING",
"source_id": "FCGR3A",
"text": "CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A",
"confidence": 0.974
}
] | {
"protein": "CD33",
"threshold": 900,
"partner_count": 5
} | 0.974 |
co_inte_00013 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFDN have with a combined association score ≥ 900? | AFDN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NECTIN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFDN",
"source_node_type": "GENE",
"source_node_label": "AFDN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFDN",
"source_db": "UniProt",
"payload": {
"accession": "P55196",
"sequence": "MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDA... | [
{
"source_db": "STRING",
"source_id": "NECTIN3",
"text": "AFDN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NECTIN3",
"confidence": 0.999
}
] | {
"protein": "AFDN",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00014 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD33 have with a combined association score ≥ 900? | CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A | {
"steps": [
{
"hop": 1,
"source_node_id": "CD33",
"source_node_type": "GENE",
"source_node_label": "CD33",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.974,
"edge_source_db": "STRING",
"t... | A | [
"A. 5",
"B. 3",
"C. 4",
"D. 6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD33",
"source_db": "UniProt",
"payload": {
"accession": "P20138",
"sequence": "MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQL... | [
{
"source_db": "STRING",
"source_id": "FCGR3A",
"text": "CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A",
"confidence": 0.974
}
] | {
"protein": "CD33",
"threshold": 900,
"partner_count": 5
} | 0.974 |
co_inte_00015 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PTEN have with a combined association score ≥ 700? | PTEN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "PTEN",
"source_node_type": "GENE",
"source_node_label": "PTEN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "STRING",
"source_id": "TP53",
"text": "PTEN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TP53",
"confidence": 0.999
}
] | {
"protein": "PTEN",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00016 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KRAS have with a combined association score ≥ 400? | KRAS PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RALGDS | {
"steps": [
{
"hop": 1,
"source_node_id": "KRAS",
"source_node_type": "GENE",
"source_node_label": "KRAS",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KRAS",
"source_db": "UniProt",
"payload": {
"accession": "P01116",
"sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLA... | [
{
"source_db": "STRING",
"source_id": "RALGDS",
"text": "KRAS PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RALGDS",
"confidence": 0.999
}
] | {
"protein": "KRAS",
"threshold": 400,
"partner_count": 10
} | 0.999 |
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