id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_inte_00017 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does NF1 have with a combined association score ≥ 400? | NF1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KRAS | {
"steps": [
{
"hop": 1,
"source_node_id": "NF1",
"source_node_type": "GENE",
"source_node_label": "NF1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.996,
"edge_source_db": "STRING",
"tar... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NF1",
"source_db": "UniProt",
"payload": {
"accession": "P21359",
"sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELR... | [
{
"source_db": "STRING",
"source_id": "KRAS",
"text": "NF1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KRAS",
"confidence": 0.996
}
] | {
"protein": "NF1",
"threshold": 400,
"partner_count": 10
} | 0.996 |
co_inte_00018 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDK1 have with a combined association score ≥ 900? | CDK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNA2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "STRING",
"source_id": "CCNA2",
"text": "CDK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNA2",
"confidence": 0.999
}
] | {
"protein": "CDK1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00019 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DDX41 have with a combined association score ≥ 700? | DDX41 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "DDX41",
"source_node_type": "GENE",
"source_node_label": "DDX41",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.936,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DDX41",
"source_db": "UniProt",
"payload": {
"accession": "Q9UJV9",
"sequence": "MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMA... | [
{
"source_db": "STRING",
"source_id": "TBK1",
"text": "DDX41 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1",
"confidence": 0.936
}
] | {
"protein": "DDX41",
"threshold": 700,
"partner_count": 10
} | 0.936 |
co_inte_00020 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does HTT have with a combined association score ≥ 700? | HTT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HAP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HTT",
"source_node_type": "GENE",
"source_node_label": "HTT",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HTT",
"source_db": "UniProt",
"payload": {
"accession": "P42858",
"sequence": "MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLC... | [
{
"source_db": "STRING",
"source_id": "HAP1",
"text": "HTT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HAP1",
"confidence": 0.999
}
] | {
"protein": "HTT",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00021 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1A have with a combined association score ≥ 400? | ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1A",
"source_node_type": "GENE",
"source_node_label": "ATP6V1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1A",
"source_db": "UniProt",
"payload": {
"accession": "P38606",
"sequence": "MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDI... | [
{
"source_db": "STRING",
"source_id": "ATP6V0A1",
"text": "ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1",
"confidence": 0.999
}
] | {
"protein": "ATP6V1A",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00022 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does TUBA4A have with a combined association score ≥ 400? | TUBA4A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TUBB2A | {
"steps": [
{
"hop": 1,
"source_node_id": "TUBA4A",
"source_node_type": "GENE",
"source_node_label": "TUBA4A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.995,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TUBA4A",
"source_db": "UniProt",
"payload": {
"accession": "P68366",
"sequence": "MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGL... | [
{
"source_db": "STRING",
"source_id": "TUBB2A",
"text": "TUBA4A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TUBB2A",
"confidence": 0.995
}
] | {
"protein": "TUBA4A",
"threshold": 400,
"partner_count": 10
} | 0.995 |
co_inte_00023 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ZMYM3 have with a combined association score ≥ 400? | ZMYM3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GTF2I | {
"steps": [
{
"hop": 1,
"source_node_id": "ZMYM3",
"source_node_type": "GENE",
"source_node_label": "ZMYM3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.916,
"edge_source_db": "STRING",
... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ZMYM3",
"source_db": "UniProt",
"payload": {
"accession": "Q14202",
"sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGAN... | [
{
"source_db": "STRING",
"source_id": "GTF2I",
"text": "ZMYM3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GTF2I",
"confidence": 0.916
}
] | {
"protein": "ZMYM3",
"threshold": 400,
"partner_count": 10
} | 0.916 |
co_inte_00024 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PDE10A have with a combined association score ≥ 900? | PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "PDE10A",
"source_node_type": "GENE",
"source_node_label": "PDE10A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.934,
"edge_source_db": "STRING",
... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PDE10A",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y233",
"sequence": "MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPS... | [
{
"source_db": "STRING",
"source_id": "ENPP3",
"text": "PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3",
"confidence": 0.934
}
] | {
"protein": "PDE10A",
"threshold": 900,
"partner_count": 10
} | 0.934 |
co_inte_00025 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does JAK2 have with a combined association score ≥ 700? | JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "JAK2",
"source_node_type": "GENE",
"source_node_label": "JAK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "STRING",
"source_id": "STAT1",
"text": "JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1",
"confidence": 0.999
}
] | {
"protein": "JAK2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00026 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFP have with a combined association score ≥ 400? | AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFP",
"source_node_type": "GENE",
"source_node_label": "AFP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.973,
"edge_source_db": "STRING",
"tar... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFP",
"source_db": "UniProt",
"payload": {
"accession": "P02771",
"sequence": "MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPAS... | [
{
"source_db": "STRING",
"source_id": "F2",
"text": "AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2",
"confidence": 0.973
}
] | {
"protein": "AFP",
"threshold": 400,
"partner_count": 10
} | 0.973 |
co_inte_00027 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASS4 have with a combined association score ≥ 400? | CASS4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NME8 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASS4",
"source_node_type": "GENE",
"source_node_label": "CASS4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.814,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASS4",
"source_db": "UniProt",
"payload": {
"accession": "Q9NQ75",
"sequence": "MKGTGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEF... | [
{
"source_db": "STRING",
"source_id": "NME8",
"text": "CASS4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NME8",
"confidence": 0.814
}
] | {
"protein": "CASS4",
"threshold": 400,
"partner_count": 10
} | 0.814 |
co_inte_00028 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SPTLC2 have with a combined association score ≥ 400? | SPTLC2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPTLC2",
"source_node_type": "GENE",
"source_node_label": "SPTLC2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPTLC2",
"source_db": "UniProt",
"payload": {
"accession": "O15270",
"sequence": "MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRD... | [
{
"source_db": "STRING",
"source_id": "SPTLC1",
"text": "SPTLC2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC1",
"confidence": 0.999
}
] | {
"protein": "SPTLC2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00029 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1C1 have with a combined association score ≥ 900? | ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1C1",
"source_node_type": "GENE",
"source_node_label": "ATP6V1C1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1C1",
"source_db": "UniProt",
"payload": {
"accession": "P21283",
"sequence": "MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVT... | [
{
"source_db": "STRING",
"source_id": "ATP6V1A",
"text": "ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A",
"confidence": 0.999
}
] | {
"protein": "ATP6V1C1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00030 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CTNNB1 have with a combined association score ≥ 700? | CTNNB1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TCF7 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "STRING",
"source_id": "TCF7",
"text": "CTNNB1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TCF7",
"confidence": 0.999
}
] | {
"protein": "CTNNB1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00031 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ADM have with a combined association score ≥ 700? | ADM PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAMP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ADM",
"source_node_type": "GENE",
"source_node_label": "ADM",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ADM",
"source_db": "UniProt",
"payload": {
"accession": "P35318",
"sequence": "MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNV... | [
{
"source_db": "STRING",
"source_id": "RAMP3",
"text": "ADM PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAMP3",
"confidence": 0.999
}
] | {
"protein": "ADM",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00032 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1B2 have with a combined association score ≥ 900? | ATP6V1B2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1H | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1B2",
"source_node_type": "GENE",
"source_node_label": "ATP6V1B2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1B2",
"source_db": "UniProt",
"payload": {
"accession": "P21281",
"sequence": "MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGR... | [
{
"source_db": "STRING",
"source_id": "ATP6V1H",
"text": "ATP6V1B2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1H",
"confidence": 0.999
}
] | {
"protein": "ATP6V1B2",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00033 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASP2 have with a combined association score ≥ 700? | CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASP2",
"source_node_type": "GENE",
"source_node_label": "CASP2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP2",
"source_db": "UniProt",
"payload": {
"accession": "P42575",
"sequence": "MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLS... | [
{
"source_db": "STRING",
"source_id": "PIDD1",
"text": "CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1",
"confidence": 0.999
}
] | {
"protein": "CASP2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00034 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1C1 have with a combined association score ≥ 900? | ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1C1",
"source_node_type": "GENE",
"source_node_label": "ATP6V1C1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1C1",
"source_db": "UniProt",
"payload": {
"accession": "P21283",
"sequence": "MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVT... | [
{
"source_db": "STRING",
"source_id": "ATP6V1A",
"text": "ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A",
"confidence": 0.999
}
] | {
"protein": "ATP6V1C1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00035 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does OPTN have with a combined association score ≥ 700? | OPTN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "OPTN",
"source_node_type": "GENE",
"source_node_label": "OPTN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "OPTN",
"source_db": "UniProt",
"payload": {
"accession": "Q96CV9",
"sequence": "MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA... | [
{
"source_db": "STRING",
"source_id": "TBK1",
"text": "OPTN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1",
"confidence": 0.999
}
] | {
"protein": "OPTN",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00036 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does HAP1 have with a combined association score ≥ 700? | HAP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HTT | {
"steps": [
{
"hop": 1,
"source_node_id": "HAP1",
"source_node_type": "GENE",
"source_node_label": "HAP1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HAP1",
"source_db": "UniProt",
"payload": {
"accession": "P54257",
"sequence": "MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQFLSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIWKTPAA... | [
{
"source_db": "STRING",
"source_id": "HTT",
"text": "HAP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HTT",
"confidence": 0.999
}
] | {
"protein": "HAP1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00037 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CFAP410 have with a combined association score ≥ 900? | CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CFAP410",
"source_node_type": "GENE",
"source_node_label": "CFAP410",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.982,
"edge_source_db": "STRING",
... | C | [
"A. 0",
"B. 0",
"C. 1",
"D. 2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CFAP410",
"source_db": "UniProt",
"payload": {
"accession": "O43822",
"sequence": "MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEEL... | [
{
"source_db": "STRING",
"source_id": "NEK1",
"text": "CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1",
"confidence": 0.982
}
] | {
"protein": "CFAP410",
"threshold": 900,
"partner_count": 1
} | 0.982 |
co_inte_00038 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDK12 have with a combined association score ≥ 900? | CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK12",
"source_node_type": "GENE",
"source_node_label": "CDK12",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 7",
"C. 8",
"D. 6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK12",
"source_db": "UniProt",
"payload": {
"accession": "Q9NYV4",
"sequence": "MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKS... | [
{
"source_db": "STRING",
"source_id": "CCNK",
"text": "CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK",
"confidence": 0.999
}
] | {
"protein": "CDK12",
"threshold": 900,
"partner_count": 8
} | 0.999 |
co_inte_00039 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD33 have with a combined association score ≥ 700? | CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A | {
"steps": [
{
"hop": 1,
"source_node_id": "CD33",
"source_node_type": "GENE",
"source_node_label": "CD33",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.974,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD33",
"source_db": "UniProt",
"payload": {
"accession": "P20138",
"sequence": "MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQL... | [
{
"source_db": "STRING",
"source_id": "FCGR3A",
"text": "CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A",
"confidence": 0.974
}
] | {
"protein": "CD33",
"threshold": 700,
"partner_count": 10
} | 0.974 |
co_inte_00040 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does TBK1 have with a combined association score ≥ 400? | TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3 | {
"steps": [
{
"hop": 1,
"source_node_id": "TBK1",
"source_node_type": "GENE",
"source_node_label": "TBK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "STRING",
"source_id": "IRF3",
"text": "TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3",
"confidence": 0.999
}
] | {
"protein": "TBK1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00041 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ALK have with a combined association score ≥ 400? | ALK PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH EML4 | {
"steps": [
{
"hop": 1,
"source_node_id": "ALK",
"source_node_type": "GENE",
"source_node_label": "ALK",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ALK",
"source_db": "UniProt",
"payload": {
"accession": "Q9UM73",
"sequence": "MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKL... | [
{
"source_db": "STRING",
"source_id": "EML4",
"text": "ALK PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH EML4",
"confidence": 0.999
}
] | {
"protein": "ALK",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00042 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SETX have with a combined association score ≥ 900? | SETX PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SETX",
"source_node_type": "GENE",
"source_node_label": "SETX",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.99,
"edge_source_db": "STRING",
"ta... | A | [
"A. 7",
"B. 6",
"C. 8",
"D. 5"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SETX",
"source_db": "UniProt",
"payload": {
"accession": "Q7Z333",
"sequence": "MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERVNELCV... | [
{
"source_db": "STRING",
"source_id": "BRCA1",
"text": "SETX PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1",
"confidence": 0.99
}
] | {
"protein": "SETX",
"threshold": 900,
"partner_count": 7
} | 0.99 |
co_inte_00043 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CSF3R have with a combined association score ≥ 400? | CSF3R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CSF3R",
"source_node_type": "GENE",
"source_node_label": "CSF3R",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CSF3R",
"source_db": "UniProt",
"payload": {
"accession": "Q99062",
"sequence": "MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLM... | [
{
"source_db": "STRING",
"source_id": "CSF3",
"text": "CSF3R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF3",
"confidence": 0.999
}
] | {
"protein": "CSF3R",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00044 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CTNNB1 have with a combined association score ≥ 700? | CTNNB1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TCF7 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "STRING",
"source_id": "TCF7",
"text": "CTNNB1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TCF7",
"confidence": 0.999
}
] | {
"protein": "CTNNB1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00045 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PDE10A have with a combined association score ≥ 900? | PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "PDE10A",
"source_node_type": "GENE",
"source_node_label": "PDE10A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.934,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PDE10A",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y233",
"sequence": "MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPS... | [
{
"source_db": "STRING",
"source_id": "ENPP3",
"text": "PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3",
"confidence": 0.934
}
] | {
"protein": "PDE10A",
"threshold": 900,
"partner_count": 10
} | 0.934 |
co_inte_00046 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AURKA have with a combined association score ≥ 900? | AURKA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TPX2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AURKA",
"source_node_type": "GENE",
"source_node_label": "AURKA",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 8",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKA",
"source_db": "UniProt",
"payload": {
"accession": "O14965",
"sequence": "MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDF... | [
{
"source_db": "STRING",
"source_id": "TPX2",
"text": "AURKA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TPX2",
"confidence": 0.999
}
] | {
"protein": "AURKA",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00047 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does VAPB have with a combined association score ≥ 400? | VAPB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RMDN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "VAPB",
"source_node_type": "GENE",
"source_node_label": "VAPB",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 8",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VAPB",
"source_db": "UniProt",
"payload": {
"accession": "O95292",
"sequence": "MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHD... | [
{
"source_db": "STRING",
"source_id": "RMDN3",
"text": "VAPB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RMDN3",
"confidence": 0.999
}
] | {
"protein": "VAPB",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00048 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does RAD51C have with a combined association score ≥ 400? | RAD51C PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51B | {
"steps": [
{
"hop": 1,
"source_node_id": "RAD51C",
"source_node_type": "GENE",
"source_node_label": "RAD51C",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RAD51C",
"source_db": "UniProt",
"payload": {
"accession": "O43502",
"sequence": "MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKT... | [
{
"source_db": "STRING",
"source_id": "RAD51B",
"text": "RAD51C PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51B",
"confidence": 0.999
}
] | {
"protein": "RAD51C",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00049 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ANXA11 have with a combined association score ≥ 900? | ANXA11 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH S100A6 | {
"steps": [
{
"hop": 1,
"source_node_id": "ANXA11",
"source_node_type": "GENE",
"source_node_label": "ANXA11",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.985,
"edge_source_db": "STRING",
... | D | [
"A. 0",
"B. 3",
"C. 1",
"D. 2"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ANXA11",
"source_db": "UniProt",
"payload": {
"accession": "P50995",
"sequence": "MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQP... | [
{
"source_db": "STRING",
"source_id": "S100A6",
"text": "ANXA11 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH S100A6",
"confidence": 0.985
}
] | {
"protein": "ANXA11",
"threshold": 900,
"partner_count": 2
} | 0.985 |
co_inte_00050 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD68 have with a combined association score ≥ 700? | CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD68",
"source_node_type": "GENE",
"source_node_label": "CD68",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.922,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD68",
"source_db": "UniProt",
"payload": {
"accession": "P34810",
"sequence": "MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGF... | [
{
"source_db": "STRING",
"source_id": "LAMP3",
"text": "CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3",
"confidence": 0.922
}
] | {
"protein": "CD68",
"threshold": 700,
"partner_count": 10
} | 0.922 |
co_inte_00051 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SPTLC2 have with a combined association score ≥ 400? | SPTLC2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPTLC2",
"source_node_type": "GENE",
"source_node_label": "SPTLC2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPTLC2",
"source_db": "UniProt",
"payload": {
"accession": "O15270",
"sequence": "MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRD... | [
{
"source_db": "STRING",
"source_id": "SPTLC1",
"text": "SPTLC2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC1",
"confidence": 0.999
}
] | {
"protein": "SPTLC2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00052 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ABI1 have with a combined association score ≥ 700? | ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABI1",
"source_node_type": "GENE",
"source_node_label": "ABI1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABI1",
"source_db": "UniProt",
"payload": {
"accession": "Q8IZP0",
"sequence": "MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPV... | [
{
"source_db": "STRING",
"source_id": "WASF2",
"text": "ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2",
"confidence": 0.999
}
] | {
"protein": "ABI1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00053 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does APC have with a combined association score ≥ 400? | APC PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSNK1A1 | {
"steps": [
{
"hop": 1,
"source_node_id": "APC",
"source_node_type": "GENE",
"source_node_label": "APC",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 8",
"B. 10",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APC",
"source_db": "UniProt",
"payload": {
"accession": "P25054",
"sequence": "MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLE... | [
{
"source_db": "STRING",
"source_id": "CSNK1A1",
"text": "APC PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSNK1A1",
"confidence": 0.999
}
] | {
"protein": "APC",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00054 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CFAP410 have with a combined association score ≥ 700? | CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CFAP410",
"source_node_type": "GENE",
"source_node_label": "CFAP410",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.982,
"edge_source_db": "STRING",
... | D | [
"A. 3",
"B. 5",
"C. 2",
"D. 4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CFAP410",
"source_db": "UniProt",
"payload": {
"accession": "O43822",
"sequence": "MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEEL... | [
{
"source_db": "STRING",
"source_id": "NEK1",
"text": "CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1",
"confidence": 0.982
}
] | {
"protein": "CFAP410",
"threshold": 700,
"partner_count": 4
} | 0.982 |
co_inte_00055 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does LEPR have with a combined association score ≥ 900? | LEPR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LEP | {
"steps": [
{
"hop": 1,
"source_node_id": "LEPR",
"source_node_type": "GENE",
"source_node_label": "LEPR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 5",
"B. 6",
"C. 7",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LEPR",
"source_db": "UniProt",
"payload": {
"accession": "P48357",
"sequence": "MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLK... | [
{
"source_db": "STRING",
"source_id": "LEP",
"text": "LEPR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LEP",
"confidence": 0.999
}
] | {
"protein": "LEPR",
"threshold": 900,
"partner_count": 7
} | 0.999 |
co_inte_00056 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFP have with a combined association score ≥ 900? | AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFP",
"source_node_type": "GENE",
"source_node_label": "AFP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.973,
"edge_source_db": "STRING",
"tar... | D | [
"A. 6",
"B. 8",
"C. 5",
"D. 7"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFP",
"source_db": "UniProt",
"payload": {
"accession": "P02771",
"sequence": "MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPAS... | [
{
"source_db": "STRING",
"source_id": "F2",
"text": "AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2",
"confidence": 0.973
}
] | {
"protein": "AFP",
"threshold": 900,
"partner_count": 7
} | 0.973 |
co_inte_00057 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CTNNA1 have with a combined association score ≥ 900? | CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNA1",
"source_node_type": "GENE",
"source_node_label": "CTNNA1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "STRING",
"source_id": "CTNNB1",
"text": "CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1",
"confidence": 0.999
}
] | {
"protein": "CTNNA1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00058 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AOPEP have with a combined association score ≥ 700? | AOPEP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AGT | {
"steps": [
{
"hop": 1,
"source_node_id": "AOPEP",
"source_node_type": "GENE",
"source_node_label": "AOPEP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.769,
"edge_source_db": "STRING",
... | D | [
"A. 3",
"B. 0",
"C. 1",
"D. 2"
] | [
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AOPEP",
"source_db": "UniProt",
"payload": {
"accession": "Q8N6M6",
"sequence": "MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCD... | [
{
"source_db": "STRING",
"source_id": "AGT",
"text": "AOPEP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AGT",
"confidence": 0.769
}
] | {
"protein": "AOPEP",
"threshold": 700,
"partner_count": 2
} | 0.769 |
co_inte_00059 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACVR1B have with a combined association score ≥ 900? | ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B | {
"steps": [
{
"hop": 1,
"source_node_id": "ACVR1B",
"source_node_type": "GENE",
"source_node_label": "ACVR1B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1B",
"source_db": "UniProt",
"payload": {
"accession": "P36896",
"sequence": "MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIA... | [
{
"source_db": "STRING",
"source_id": "ACVR2B",
"text": "ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B",
"confidence": 0.999
}
] | {
"protein": "ACVR1B",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00060 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ANG have with a combined association score ≥ 900? | ANG PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RNH1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ANG",
"source_node_type": "GENE",
"source_node_label": "ANG",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 2",
"B. 4",
"C. 3",
"D. 5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ANG",
"source_db": "UniProt",
"payload": {
"accession": "P03950",
"sequence": "MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGL... | [
{
"source_db": "STRING",
"source_id": "RNH1",
"text": "ANG PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RNH1",
"confidence": 0.999
}
] | {
"protein": "ANG",
"threshold": 900,
"partner_count": 4
} | 0.999 |
co_inte_00061 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DCTN4 have with a combined association score ≥ 700? | DCTN4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6 | {
"steps": [
{
"hop": 1,
"source_node_id": "DCTN4",
"source_node_type": "GENE",
"source_node_label": "DCTN4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DCTN4",
"source_db": "UniProt",
"payload": {
"accession": "Q9UJW0",
"sequence": "MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGW... | [
{
"source_db": "STRING",
"source_id": "DCTN6",
"text": "DCTN4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6",
"confidence": 0.999
}
] | {
"protein": "DCTN4",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00062 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MSH6 have with a combined association score ≥ 400? | MSH6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PMS1 | {
"steps": [
{
"hop": 1,
"source_node_id": "MSH6",
"source_node_type": "GENE",
"source_node_label": "MSH6",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MSH6",
"source_db": "UniProt",
"payload": {
"accession": "P52701",
"sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFF... | [
{
"source_db": "STRING",
"source_id": "PMS1",
"text": "MSH6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PMS1",
"confidence": 0.999
}
] | {
"protein": "MSH6",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00063 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACVR1 have with a combined association score ≥ 900? | ACVR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BMP6 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACVR1",
"source_node_type": "GENE",
"source_node_label": "ACVR1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1",
"source_db": "UniProt",
"payload": {
"accession": "Q04771",
"sequence": "MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVF... | [
{
"source_db": "STRING",
"source_id": "BMP6",
"text": "ACVR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BMP6",
"confidence": 0.999
}
] | {
"protein": "ACVR1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00064 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ESR1 have with a combined association score ≥ 700? | ESR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SRC | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "STRING",
"source_id": "SRC",
"text": "ESR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SRC",
"confidence": 0.999
}
] | {
"protein": "ESR1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00065 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does UBQLN2 have with a combined association score ≥ 400? | UBQLN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH UBC | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.997,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "STRING",
"source_id": "UBC",
"text": "UBQLN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH UBC",
"confidence": 0.997
}
] | {
"protein": "UBQLN2",
"threshold": 400,
"partner_count": 10
} | 0.997 |
co_inte_00066 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CHEK2 have with a combined association score ≥ 900? | CHEK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CHEK2",
"source_node_type": "GENE",
"source_node_label": "CHEK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CHEK2",
"source_db": "UniProt",
"payload": {
"accession": "O96017",
"sequence": "MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRT... | [
{
"source_db": "STRING",
"source_id": "BRCA1",
"text": "CHEK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1",
"confidence": 0.999
}
] | {
"protein": "CHEK2",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00067 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ADM have with a combined association score ≥ 900? | ADM PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAMP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ADM",
"source_node_type": "GENE",
"source_node_label": "ADM",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ADM",
"source_db": "UniProt",
"payload": {
"accession": "P35318",
"sequence": "MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNV... | [
{
"source_db": "STRING",
"source_id": "RAMP3",
"text": "ADM PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAMP3",
"confidence": 0.999
}
] | {
"protein": "ADM",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00068 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does JAK2 have with a combined association score ≥ 900? | JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "JAK2",
"source_node_type": "GENE",
"source_node_label": "JAK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "STRING",
"source_id": "STAT1",
"text": "JAK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH STAT1",
"confidence": 0.999
}
] | {
"protein": "JAK2",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00069 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DCTN1 have with a combined association score ≥ 400? | DCTN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6 | {
"steps": [
{
"hop": 1,
"source_node_id": "DCTN1",
"source_node_type": "GENE",
"source_node_label": "DCTN1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DCTN1",
"source_db": "UniProt",
"payload": {
"accession": "Q14203",
"sequence": "MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRG... | [
{
"source_db": "STRING",
"source_id": "DCTN6",
"text": "DCTN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6",
"confidence": 0.999
}
] | {
"protein": "DCTN1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00070 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PSMA6 have with a combined association score ≥ 400? | PSMA6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PSMB2 | {
"steps": [
{
"hop": 1,
"source_node_id": "PSMA6",
"source_node_type": "GENE",
"source_node_label": "PSMA6",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSMA6",
"source_db": "UniProt",
"payload": {
"accession": "P60900",
"sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRP... | [
{
"source_db": "STRING",
"source_id": "PSMB2",
"text": "PSMA6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PSMB2",
"confidence": 0.999
}
] | {
"protein": "PSMA6",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00071 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASP2 have with a combined association score ≥ 900? | CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASP2",
"source_node_type": "GENE",
"source_node_label": "CASP2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 7",
"B. 6",
"C. 5",
"D. 4"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP2",
"source_db": "UniProt",
"payload": {
"accession": "P42575",
"sequence": "MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLS... | [
{
"source_db": "STRING",
"source_id": "PIDD1",
"text": "CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1",
"confidence": 0.999
}
] | {
"protein": "CASP2",
"threshold": 900,
"partner_count": 6
} | 0.999 |
co_inte_00072 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ASAH1 have with a combined association score ≥ 900? | ASAH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ASAH2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ASAH1",
"source_node_type": "GENE",
"source_node_label": "ASAH1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.993,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ASAH1",
"source_db": "UniProt",
"payload": {
"accession": "Q13510",
"sequence": "MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISF... | [
{
"source_db": "STRING",
"source_id": "ASAH2",
"text": "ASAH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ASAH2",
"confidence": 0.993
}
] | {
"protein": "ASAH1",
"threshold": 900,
"partner_count": 10
} | 0.993 |
co_inte_00073 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BIRC5 have with a combined association score ≥ 400? | BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "BIRC5",
"source_node_type": "GENE",
"source_node_label": "BIRC5",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIRC5",
"source_db": "UniProt",
"payload": {
"accession": "O15392",
"sequence": "MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRR... | [
{
"source_db": "STRING",
"source_id": "AURKB",
"text": "BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB",
"confidence": 0.999
}
] | {
"protein": "BIRC5",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00074 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BIN1 have with a combined association score ≥ 400? | BIN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RIN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "BIN1",
"source_node_type": "GENE",
"source_node_label": "BIN1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIN1",
"source_db": "UniProt",
"payload": {
"accession": "O00499",
"sequence": "MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFP... | [
{
"source_db": "STRING",
"source_id": "RIN3",
"text": "BIN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RIN3",
"confidence": 0.999
}
] | {
"protein": "BIN1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00075 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FIG4 have with a combined association score ≥ 900? | FIG4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIKFYVE | {
"steps": [
{
"hop": 1,
"source_node_id": "FIG4",
"source_node_type": "GENE",
"source_node_label": "FIG4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FIG4",
"source_db": "UniProt",
"payload": {
"accession": "Q92562",
"sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIY... | [
{
"source_db": "STRING",
"source_id": "PIKFYVE",
"text": "FIG4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIKFYVE",
"confidence": 0.999
}
] | {
"protein": "FIG4",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00076 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BCL2 have with a combined association score ≥ 700? | BCL2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BIK | {
"steps": [
{
"hop": 1,
"source_node_id": "BCL2",
"source_node_type": "GENE",
"source_node_label": "BCL2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCL2",
"source_db": "UniProt",
"payload": {
"accession": "P10415",
"sequence": "MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVV... | [
{
"source_db": "STRING",
"source_id": "BIK",
"text": "BCL2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BIK",
"confidence": 0.999
}
] | {
"protein": "BCL2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00077 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MAPK1 have with a combined association score ≥ 700? | MAPK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MAP2K1 | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPK1",
"source_node_type": "GENE",
"source_node_label": "MAPK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "STRING",
"source_id": "MAP2K1",
"text": "MAPK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MAP2K1",
"confidence": 0.999
}
] | {
"protein": "MAPK1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00078 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ERBB4 have with a combined association score ≥ 900? | ERBB4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ERBB3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ERBB4",
"source_node_type": "GENE",
"source_node_label": "ERBB4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB4",
"source_db": "UniProt",
"payload": {
"accession": "Q15303",
"sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQE... | [
{
"source_db": "STRING",
"source_id": "ERBB3",
"text": "ERBB4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ERBB3",
"confidence": 0.999
}
] | {
"protein": "ERBB4",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00079 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD274 have with a combined association score ≥ 900? | CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD274",
"source_node_type": "GENE",
"source_node_label": "CD274",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD274",
"source_db": "UniProt",
"payload": {
"accession": "Q9NZQ7",
"sequence": "MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAP... | [
{
"source_db": "STRING",
"source_id": "CD80",
"text": "CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80",
"confidence": 0.999
}
] | {
"protein": "CD274",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00080 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does APOE have with a combined association score ≥ 400? | APOE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH APOC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "APOE",
"source_node_type": "GENE",
"source_node_label": "APOE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APOE",
"source_db": "UniProt",
"payload": {
"accession": "P02649",
"sequence": "MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLV... | [
{
"source_db": "STRING",
"source_id": "APOC2",
"text": "APOE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH APOC2",
"confidence": 0.999
}
] | {
"protein": "APOE",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00081 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DNAJC6 have with a combined association score ≥ 400? | DNAJC6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSPA8 | {
"steps": [
{
"hop": 1,
"source_node_id": "DNAJC6",
"source_node_type": "GENE",
"source_node_label": "DNAJC6",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DNAJC6",
"source_db": "UniProt",
"payload": {
"accession": "O75061",
"sequence": "MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPI... | [
{
"source_db": "STRING",
"source_id": "HSPA8",
"text": "DNAJC6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSPA8",
"confidence": 0.999
}
] | {
"protein": "DNAJC6",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00082 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does NEFL have with a combined association score ≥ 900? | NEFL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEFM | {
"steps": [
{
"hop": 1,
"source_node_id": "NEFL",
"source_node_type": "GENE",
"source_node_label": "NEFL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NEFL",
"source_db": "UniProt",
"payload": {
"accession": "P07196",
"sequence": "MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR... | [
{
"source_db": "STRING",
"source_id": "NEFM",
"text": "NEFL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEFM",
"confidence": 0.999
}
] | {
"protein": "NEFL",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00083 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SETX have with a combined association score ≥ 700? | SETX PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SETX",
"source_node_type": "GENE",
"source_node_label": "SETX",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.99,
"edge_source_db": "STRING",
"ta... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SETX",
"source_db": "UniProt",
"payload": {
"accession": "Q7Z333",
"sequence": "MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERVNELCV... | [
{
"source_db": "STRING",
"source_id": "BRCA1",
"text": "SETX PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1",
"confidence": 0.99
}
] | {
"protein": "SETX",
"threshold": 700,
"partner_count": 10
} | 0.99 |
co_inte_00084 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDK12 have with a combined association score ≥ 400? | CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK12",
"source_node_type": "GENE",
"source_node_label": "CDK12",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 8",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK12",
"source_db": "UniProt",
"payload": {
"accession": "Q9NYV4",
"sequence": "MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKS... | [
{
"source_db": "STRING",
"source_id": "CCNK",
"text": "CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK",
"confidence": 0.999
}
] | {
"protein": "CDK12",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00085 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SLC18A2 have with a combined association score ≥ 900? | SLC18A2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCA | {
"steps": [
{
"hop": 1,
"source_node_id": "SLC18A2",
"source_node_type": "GENE",
"source_node_label": "SLC18A2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.979,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SLC18A2",
"source_db": "UniProt",
"payload": {
"accession": "Q05940",
"sequence": "MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQV... | [
{
"source_db": "STRING",
"source_id": "SNCA",
"text": "SLC18A2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCA",
"confidence": 0.979
}
] | {
"protein": "SLC18A2",
"threshold": 900,
"partner_count": 10
} | 0.979 |
co_inte_00086 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does POLE have with a combined association score ≥ 700? | POLE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH POLE3 | {
"steps": [
{
"hop": 1,
"source_node_id": "POLE",
"source_node_type": "GENE",
"source_node_label": "POLE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "POLE",
"source_db": "UniProt",
"payload": {
"accession": "Q07864",
"sequence": "MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETV... | [
{
"source_db": "STRING",
"source_id": "POLE3",
"text": "POLE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH POLE3",
"confidence": 0.999
}
] | {
"protein": "POLE",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00087 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AKT1 have with a combined association score ≥ 700? | AKT1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MTOR | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT1",
"source_node_type": "GENE",
"source_node_label": "AKT1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT1",
"source_db": "UniProt",
"payload": {
"accession": "P31749",
"sequence": "MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEM... | [
{
"source_db": "STRING",
"source_id": "MTOR",
"text": "AKT1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MTOR",
"confidence": 0.999
}
] | {
"protein": "AKT1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00088 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1B2 have with a combined association score ≥ 700? | ATP6V1B2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1H | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1B2",
"source_node_type": "GENE",
"source_node_label": "ATP6V1B2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1B2",
"source_db": "UniProt",
"payload": {
"accession": "P21281",
"sequence": "MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGR... | [
{
"source_db": "STRING",
"source_id": "ATP6V1H",
"text": "ATP6V1B2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1H",
"confidence": 0.999
}
] | {
"protein": "ATP6V1B2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00089 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MTA3 have with a combined association score ≥ 700? | MTA3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RBBP7 | {
"steps": [
{
"hop": 1,
"source_node_id": "MTA3",
"source_node_type": "GENE",
"source_node_label": "MTA3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MTA3",
"source_db": "UniProt",
"payload": {
"accession": "Q9BTC8",
"sequence": "MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSL... | [
{
"source_db": "STRING",
"source_id": "RBBP7",
"text": "MTA3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RBBP7",
"confidence": 0.999
}
] | {
"protein": "MTA3",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00090 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CREBBP have with a combined association score ≥ 700? | CREBBP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MYB | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "STRING",
"source_id": "MYB",
"text": "CREBBP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MYB",
"confidence": 0.999
}
] | {
"protein": "CREBBP",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00091 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does IGFBP3 have with a combined association score ≥ 700? | IGFBP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IGFALS | {
"steps": [
{
"hop": 1,
"source_node_id": "IGFBP3",
"source_node_type": "GENE",
"source_node_label": "IGFBP3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "IGFBP3",
"source_db": "UniProt",
"payload": {
"accession": "P17936",
"sequence": "MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPP... | [
{
"source_db": "STRING",
"source_id": "IGFALS",
"text": "IGFBP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IGFALS",
"confidence": 0.999
}
] | {
"protein": "IGFBP3",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00092 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ADAM10 have with a combined association score ≥ 900? | ADAM10 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TSPAN33 | {
"steps": [
{
"hop": 1,
"source_node_id": "ADAM10",
"source_node_type": "GENE",
"source_node_label": "ADAM10",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.987,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ADAM10",
"source_db": "UniProt",
"payload": {
"accession": "O14672",
"sequence": "MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRG... | [
{
"source_db": "STRING",
"source_id": "TSPAN33",
"text": "ADAM10 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TSPAN33",
"confidence": 0.987
}
] | {
"protein": "ADAM10",
"threshold": 900,
"partner_count": 10
} | 0.987 |
co_inte_00093 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD2AP have with a combined association score ≥ 400? | CD2AP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NPHS1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD2AP",
"source_node_type": "GENE",
"source_node_label": "CD2AP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD2AP",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y5K6",
"sequence": "MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGD... | [
{
"source_db": "STRING",
"source_id": "NPHS1",
"text": "CD2AP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NPHS1",
"confidence": 0.999
}
] | {
"protein": "CD2AP",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00094 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ABI1 have with a combined association score ≥ 700? | ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABI1",
"source_node_type": "GENE",
"source_node_label": "ABI1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABI1",
"source_db": "UniProt",
"payload": {
"accession": "Q8IZP0",
"sequence": "MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPV... | [
{
"source_db": "STRING",
"source_id": "WASF2",
"text": "ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2",
"confidence": 0.999
}
] | {
"protein": "ABI1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00095 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SYNJ1 have with a combined association score ≥ 400? | SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SYNJ1",
"source_node_type": "GENE",
"source_node_label": "SYNJ1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.998,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SYNJ1",
"source_db": "UniProt",
"payload": {
"accession": "O43426",
"sequence": "MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWS... | [
{
"source_db": "STRING",
"source_id": "SH3GL2",
"text": "SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2",
"confidence": 0.998
}
] | {
"protein": "SYNJ1",
"threshold": 400,
"partner_count": 10
} | 0.998 |
co_inte_00096 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does HTT have with a combined association score ≥ 700? | HTT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HAP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HTT",
"source_node_type": "GENE",
"source_node_label": "HTT",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HTT",
"source_db": "UniProt",
"payload": {
"accession": "P42858",
"sequence": "MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLC... | [
{
"source_db": "STRING",
"source_id": "HAP1",
"text": "HTT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HAP1",
"confidence": 0.999
}
] | {
"protein": "HTT",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00097 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PIK3CA have with a combined association score ≥ 400? | PIK3CA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIK3R5 | {
"steps": [
{
"hop": 1,
"source_node_id": "PIK3CA",
"source_node_type": "GENE",
"source_node_label": "PIK3CA",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PIK3CA",
"source_db": "UniProt",
"payload": {
"accession": "P42336",
"sequence": "MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVK... | [
{
"source_db": "STRING",
"source_id": "PIK3R5",
"text": "PIK3CA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIK3R5",
"confidence": 0.999
}
] | {
"protein": "PIK3CA",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00098 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CREBBP have with a combined association score ≥ 400? | CREBBP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MYB | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "STRING",
"source_id": "MYB",
"text": "CREBBP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MYB",
"confidence": 0.999
}
] | {
"protein": "CREBBP",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00099 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FAT4 have with a combined association score ≥ 900? | FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FAT4",
"source_node_type": "GENE",
"source_node_label": "FAT4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.928,
"edge_source_db": "STRING",
"t... | C | [
"A. 0",
"B. 0",
"C. 1",
"D. 2"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FAT4",
"source_db": "UniProt",
"payload": {
"accession": "Q6V0I7",
"sequence": "MDLAPDRATGRPWLPLHTLSVSQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPV... | [
{
"source_db": "STRING",
"source_id": "FJX1",
"text": "FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1",
"confidence": 0.928
}
] | {
"protein": "FAT4",
"threshold": 900,
"partner_count": 1
} | 0.928 |
co_inte_00100 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does NOTCH1 have with a combined association score ≥ 700? | NOTCH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DLL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "NOTCH1",
"source_node_type": "GENE",
"source_node_label": "NOTCH1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NOTCH1",
"source_db": "UniProt",
"payload": {
"accession": "P46531",
"sequence": "MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG... | [
{
"source_db": "STRING",
"source_id": "DLL1",
"text": "NOTCH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DLL1",
"confidence": 0.999
}
] | {
"protein": "NOTCH1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00101 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AVPR1A have with a combined association score ≥ 900? | AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP | {
"steps": [
{
"hop": 1,
"source_node_id": "AVPR1A",
"source_node_type": "GENE",
"source_node_label": "AVPR1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 7",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AVPR1A",
"source_db": "UniProt",
"payload": {
"accession": "P37288",
"sequence": "MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQV... | [
{
"source_db": "STRING",
"source_id": "AVP",
"text": "AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP",
"confidence": 0.999
}
] | {
"protein": "AVPR1A",
"threshold": 900,
"partner_count": 9
} | 0.999 |
co_inte_00102 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does RXRA have with a combined association score ≥ 900? | RXRA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NR1H4 | {
"steps": [
{
"hop": 1,
"source_node_id": "RXRA",
"source_node_type": "GENE",
"source_node_label": "RXRA",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RXRA",
"source_db": "UniProt",
"payload": {
"accession": "P19793",
"sequence": "MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHI... | [
{
"source_db": "STRING",
"source_id": "NR1H4",
"text": "RXRA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NR1H4",
"confidence": 0.999
}
] | {
"protein": "RXRA",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00103 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACVR1B have with a combined association score ≥ 700? | ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B | {
"steps": [
{
"hop": 1,
"source_node_id": "ACVR1B",
"source_node_type": "GENE",
"source_node_label": "ACVR1B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1B",
"source_db": "UniProt",
"payload": {
"accession": "P36896",
"sequence": "MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIA... | [
{
"source_db": "STRING",
"source_id": "ACVR2B",
"text": "ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B",
"confidence": 0.999
}
] | {
"protein": "ACVR1B",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00104 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PARK7 have with a combined association score ≥ 700? | PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PINK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK7",
"source_node_type": "GENE",
"source_node_label": "PARK7",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PARK7",
"source_db": "UniProt",
"payload": {
"accession": "Q99497",
"sequence": "MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKM... | [
{
"source_db": "STRING",
"source_id": "PINK1",
"text": "PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PINK1",
"confidence": 0.999
}
] | {
"protein": "PARK7",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00105 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does LRRK2 have with a combined association score ≥ 700? | LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29 | {
"steps": [
{
"hop": 1,
"source_node_id": "LRRK2",
"source_node_type": "GENE",
"source_node_label": "LRRK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.995,
"edge_source_db": "STRING",
... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "STRING",
"source_id": "RAB29",
"text": "LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29",
"confidence": 0.995
}
] | {
"protein": "LRRK2",
"threshold": 700,
"partner_count": 10
} | 0.995 |
co_inte_00106 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does NEFL have with a combined association score ≥ 700? | NEFL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEFM | {
"steps": [
{
"hop": 1,
"source_node_id": "NEFL",
"source_node_type": "GENE",
"source_node_label": "NEFL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NEFL",
"source_db": "UniProt",
"payload": {
"accession": "P07196",
"sequence": "MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSR... | [
{
"source_db": "STRING",
"source_id": "NEFM",
"text": "NEFL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEFM",
"confidence": 0.999
}
] | {
"protein": "NEFL",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00107 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BIN1 have with a combined association score ≥ 400? | BIN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RIN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "BIN1",
"source_node_type": "GENE",
"source_node_label": "BIN1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIN1",
"source_db": "UniProt",
"payload": {
"accession": "O00499",
"sequence": "MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFP... | [
{
"source_db": "STRING",
"source_id": "RIN3",
"text": "BIN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RIN3",
"confidence": 0.999
}
] | {
"protein": "BIN1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00108 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SPTLC1 have with a combined association score ≥ 700? | SPTLC1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPTLC1",
"source_node_type": "GENE",
"source_node_label": "SPTLC1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPTLC1",
"source_db": "UniProt",
"payload": {
"accession": "O15269",
"sequence": "MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGT... | [
{
"source_db": "STRING",
"source_id": "SPTLC2",
"text": "SPTLC1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC2",
"confidence": 0.999
}
] | {
"protein": "SPTLC1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00109 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDH1 have with a combined association score ≥ 900? | CDH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KLRG1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDH1",
"source_node_type": "GENE",
"source_node_label": "CDH1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDH1",
"source_db": "UniProt",
"payload": {
"accession": "P12830",
"sequence": "MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSG... | [
{
"source_db": "STRING",
"source_id": "KLRG1",
"text": "CDH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH KLRG1",
"confidence": 0.999
}
] | {
"protein": "CDH1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00110 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ABI1 have with a combined association score ≥ 900? | ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABI1",
"source_node_type": "GENE",
"source_node_label": "ABI1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABI1",
"source_db": "UniProt",
"payload": {
"accession": "Q8IZP0",
"sequence": "MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPV... | [
{
"source_db": "STRING",
"source_id": "WASF2",
"text": "ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2",
"confidence": 0.999
}
] | {
"protein": "ABI1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00111 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does OPTN have with a combined association score ≥ 700? | OPTN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "OPTN",
"source_node_type": "GENE",
"source_node_label": "OPTN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "OPTN",
"source_db": "UniProt",
"payload": {
"accession": "Q96CV9",
"sequence": "MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA... | [
{
"source_db": "STRING",
"source_id": "TBK1",
"text": "OPTN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TBK1",
"confidence": 0.999
}
] | {
"protein": "OPTN",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00112 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CTNNA1 have with a combined association score ≥ 400? | CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNA1",
"source_node_type": "GENE",
"source_node_label": "CTNNA1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "STRING",
"source_id": "CTNNB1",
"text": "CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1",
"confidence": 0.999
}
] | {
"protein": "CTNNA1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00113 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFF3 have with a combined association score ≥ 700? | AFF3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MLLT3 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFF3",
"source_node_type": "GENE",
"source_node_label": "AFF3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.964,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFF3",
"source_db": "UniProt",
"payload": {
"accession": "P51826",
"sequence": "MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPA... | [
{
"source_db": "STRING",
"source_id": "MLLT3",
"text": "AFF3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MLLT3",
"confidence": 0.964
}
] | {
"protein": "AFF3",
"threshold": 700,
"partner_count": 10
} | 0.964 |
co_inte_00114 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CSF3R have with a combined association score ≥ 900? | CSF3R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CSF3R",
"source_node_type": "GENE",
"source_node_label": "CSF3R",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CSF3R",
"source_db": "UniProt",
"payload": {
"accession": "Q99062",
"sequence": "MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLM... | [
{
"source_db": "STRING",
"source_id": "CSF3",
"text": "CSF3R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF3",
"confidence": 0.999
}
] | {
"protein": "CSF3R",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00115 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SPTLC1 have with a combined association score ≥ 900? | SPTLC1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPTLC1",
"source_node_type": "GENE",
"source_node_label": "SPTLC1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPTLC1",
"source_db": "UniProt",
"payload": {
"accession": "O15269",
"sequence": "MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGT... | [
{
"source_db": "STRING",
"source_id": "SPTLC2",
"text": "SPTLC1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SPTLC2",
"confidence": 0.999
}
] | {
"protein": "SPTLC1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00116 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1C1 have with a combined association score ≥ 900? | ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1C1",
"source_node_type": "GENE",
"source_node_label": "ATP6V1C1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1C1",
"source_db": "UniProt",
"payload": {
"accession": "P21283",
"sequence": "MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVT... | [
{
"source_db": "STRING",
"source_id": "ATP6V1A",
"text": "ATP6V1C1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V1A",
"confidence": 0.999
}
] | {
"protein": "ATP6V1C1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
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