id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_inte_00117 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MAPT have with a combined association score ≥ 400? | MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5 | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPT",
"source_node_type": "GENE",
"source_node_label": "MAPT",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPT",
"source_db": "UniProt",
"payload": {
"accession": "P10636",
"sequence": "MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQE... | [
{
"source_db": "STRING",
"source_id": "CDK5",
"text": "MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5",
"confidence": 0.999
}
] | {
"protein": "MAPT",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00118 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BRIP1 have with a combined association score ≥ 900? | BRIP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRIP1",
"source_node_type": "GENE",
"source_node_label": "BRIP1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRIP1",
"source_db": "UniProt",
"payload": {
"accession": "Q9BX63",
"sequence": "MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTT... | [
{
"source_db": "STRING",
"source_id": "BRCA1",
"text": "BRIP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1",
"confidence": 0.999
}
] | {
"protein": "BRIP1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00119 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SFRP4 have with a combined association score ≥ 400? | SFRP4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WNT3A | {
"steps": [
{
"hop": 1,
"source_node_id": "SFRP4",
"source_node_type": "GENE",
"source_node_label": "SFRP4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.924,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SFRP4",
"source_db": "UniProt",
"payload": {
"accession": "Q6FHJ7",
"sequence": "MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDR... | [
{
"source_db": "STRING",
"source_id": "WNT3A",
"text": "SFRP4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WNT3A",
"confidence": 0.924
}
] | {
"protein": "SFRP4",
"threshold": 400,
"partner_count": 10
} | 0.924 |
co_inte_00120 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1A have with a combined association score ≥ 900? | ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1A",
"source_node_type": "GENE",
"source_node_label": "ATP6V1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1A",
"source_db": "UniProt",
"payload": {
"accession": "P38606",
"sequence": "MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDI... | [
{
"source_db": "STRING",
"source_id": "ATP6V0A1",
"text": "ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1",
"confidence": 0.999
}
] | {
"protein": "ATP6V1A",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00121 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PFN1 have with a combined association score ≥ 900? | PFN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH VASP | {
"steps": [
{
"hop": 1,
"source_node_id": "PFN1",
"source_node_type": "GENE",
"source_node_label": "PFN1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PFN1",
"source_db": "UniProt",
"payload": {
"accession": "P07737",
"sequence": "MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASH... | [
{
"source_db": "STRING",
"source_id": "VASP",
"text": "PFN1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH VASP",
"confidence": 0.999
}
] | {
"protein": "PFN1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00122 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ZMYM3 have with a combined association score ≥ 900? | ZMYM3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GTF2I | {
"steps": [
{
"hop": 1,
"source_node_id": "ZMYM3",
"source_node_type": "GENE",
"source_node_label": "ZMYM3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.916,
"edge_source_db": "STRING",
... | D | [
"A. 4",
"B. 1",
"C. 2",
"D. 3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ZMYM3",
"source_db": "UniProt",
"payload": {
"accession": "Q14202",
"sequence": "MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGAN... | [
{
"source_db": "STRING",
"source_id": "GTF2I",
"text": "ZMYM3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH GTF2I",
"confidence": 0.916
}
] | {
"protein": "ZMYM3",
"threshold": 900,
"partner_count": 3
} | 0.916 |
co_inte_00123 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PIK3CA have with a combined association score ≥ 400? | PIK3CA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIK3R5 | {
"steps": [
{
"hop": 1,
"source_node_id": "PIK3CA",
"source_node_type": "GENE",
"source_node_label": "PIK3CA",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PIK3CA",
"source_db": "UniProt",
"payload": {
"accession": "P42336",
"sequence": "MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVK... | [
{
"source_db": "STRING",
"source_id": "PIK3R5",
"text": "PIK3CA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIK3R5",
"confidence": 0.999
}
] | {
"protein": "PIK3CA",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00124 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does UBQLN2 have with a combined association score ≥ 900? | UBQLN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH UBC | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.997,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "STRING",
"source_id": "UBC",
"text": "UBQLN2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH UBC",
"confidence": 0.997
}
] | {
"protein": "UBQLN2",
"threshold": 900,
"partner_count": 10
} | 0.997 |
co_inte_00125 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does LEPR have with a combined association score ≥ 700? | LEPR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LEP | {
"steps": [
{
"hop": 1,
"source_node_id": "LEPR",
"source_node_type": "GENE",
"source_node_label": "LEPR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LEPR",
"source_db": "UniProt",
"payload": {
"accession": "P48357",
"sequence": "MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLK... | [
{
"source_db": "STRING",
"source_id": "LEP",
"text": "LEPR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LEP",
"confidence": 0.999
}
] | {
"protein": "LEPR",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00126 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CAMK4 have with a combined association score ≥ 900? | CAMK4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CALML4 | {
"steps": [
{
"hop": 1,
"source_node_id": "CAMK4",
"source_node_type": "GENE",
"source_node_label": "CAMK4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.998,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CAMK4",
"source_db": "UniProt",
"payload": {
"accession": "Q16566",
"sequence": "MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEK... | [
{
"source_db": "STRING",
"source_id": "CALML4",
"text": "CAMK4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CALML4",
"confidence": 0.998
}
] | {
"protein": "CAMK4",
"threshold": 900,
"partner_count": 10
} | 0.998 |
co_inte_00127 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BRIP1 have with a combined association score ≥ 400? | BRIP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRIP1",
"source_node_type": "GENE",
"source_node_label": "BRIP1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRIP1",
"source_db": "UniProt",
"payload": {
"accession": "Q9BX63",
"sequence": "MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTT... | [
{
"source_db": "STRING",
"source_id": "BRCA1",
"text": "BRIP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BRCA1",
"confidence": 0.999
}
] | {
"protein": "BRIP1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00128 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PARK7 have with a combined association score ≥ 400? | PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PINK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK7",
"source_node_type": "GENE",
"source_node_label": "PARK7",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PARK7",
"source_db": "UniProt",
"payload": {
"accession": "Q99497",
"sequence": "MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKM... | [
{
"source_db": "STRING",
"source_id": "PINK1",
"text": "PARK7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PINK1",
"confidence": 0.999
}
] | {
"protein": "PARK7",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00129 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PRKN have with a combined association score ≥ 900? | PRKN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP | {
"steps": [
{
"hop": 1,
"source_node_id": "PRKN",
"source_node_type": "GENE",
"source_node_label": "PRKN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PRKN",
"source_db": "UniProt",
"payload": {
"accession": "O60260",
"sequence": "MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPA... | [
{
"source_db": "STRING",
"source_id": "SNCAIP",
"text": "PRKN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP",
"confidence": 0.999
}
] | {
"protein": "PRKN",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00130 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SNCA have with a combined association score ≥ 900? | SNCA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP | {
"steps": [
{
"hop": 1,
"source_node_id": "SNCA",
"source_node_type": "GENE",
"source_node_label": "SNCA",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SNCA",
"source_db": "UniProt",
"payload": {
"accession": "P37840",
"sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQ... | [
{
"source_db": "STRING",
"source_id": "SNCAIP",
"text": "SNCA PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP",
"confidence": 0.999
}
] | {
"protein": "SNCA",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00131 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SYNJ1 have with a combined association score ≥ 900? | SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SYNJ1",
"source_node_type": "GENE",
"source_node_label": "SYNJ1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.998,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SYNJ1",
"source_db": "UniProt",
"payload": {
"accession": "O43426",
"sequence": "MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWS... | [
{
"source_db": "STRING",
"source_id": "SH3GL2",
"text": "SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2",
"confidence": 0.998
}
] | {
"protein": "SYNJ1",
"threshold": 900,
"partner_count": 10
} | 0.998 |
co_inte_00132 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CA9 have with a combined association score ≥ 400? | CA9 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HIF1A | {
"steps": [
{
"hop": 1,
"source_node_id": "CA9",
"source_node_type": "GENE",
"source_node_label": "CA9",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.944,
"edge_source_db": "STRING",
"tar... | B | [
"A. 11",
"B. 10",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CA9",
"source_db": "UniProt",
"payload": {
"accession": "Q16790",
"sequence": "MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEG... | [
{
"source_db": "STRING",
"source_id": "HIF1A",
"text": "CA9 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HIF1A",
"confidence": 0.944
}
] | {
"protein": "CA9",
"threshold": 400,
"partner_count": 10
} | 0.944 |
co_inte_00133 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FAT4 have with a combined association score ≥ 900? | FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FAT4",
"source_node_type": "GENE",
"source_node_label": "FAT4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.928,
"edge_source_db": "STRING",
"t... | C | [
"A. 0",
"B. 0",
"C. 1",
"D. 2"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FAT4",
"source_db": "UniProt",
"payload": {
"accession": "Q6V0I7",
"sequence": "MDLAPDRATGRPWLPLHTLSVSQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPV... | [
{
"source_db": "STRING",
"source_id": "FJX1",
"text": "FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1",
"confidence": 0.928
}
] | {
"protein": "FAT4",
"threshold": 900,
"partner_count": 1
} | 0.928 |
co_inte_00134 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does TP53 have with a combined association score ≥ 900? | TP53 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SFN | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "STRING",
"source_id": "SFN",
"text": "TP53 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SFN",
"confidence": 0.999
}
] | {
"protein": "TP53",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00135 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MTOR have with a combined association score ≥ 700? | MTOR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RRAGA | {
"steps": [
{
"hop": 1,
"source_node_id": "MTOR",
"source_node_type": "GENE",
"source_node_label": "MTOR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MTOR",
"source_db": "UniProt",
"payload": {
"accession": "P42345",
"sequence": "MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLA... | [
{
"source_db": "STRING",
"source_id": "RRAGA",
"text": "MTOR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RRAGA",
"confidence": 0.999
}
] | {
"protein": "MTOR",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00136 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CBL have with a combined association score ≥ 700? | CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "STRING",
"source_id": "MET",
"text": "CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET",
"confidence": 0.999
}
] | {
"protein": "CBL",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00137 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AKT2 have with a combined association score ≥ 900? | AKT2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PHLPP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT2",
"source_node_type": "GENE",
"source_node_label": "AKT2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.994,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT2",
"source_db": "UniProt",
"payload": {
"accession": "P31751",
"sequence": "MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTE... | [
{
"source_db": "STRING",
"source_id": "PHLPP1",
"text": "AKT2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PHLPP1",
"confidence": 0.994
}
] | {
"protein": "AKT2",
"threshold": 900,
"partner_count": 10
} | 0.994 |
co_inte_00138 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FAT4 have with a combined association score ≥ 700? | FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FAT4",
"source_node_type": "GENE",
"source_node_label": "FAT4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.928,
"edge_source_db": "STRING",
"t... | B | [
"A. 1",
"B. 3",
"C. 4",
"D. 2"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FAT4",
"source_db": "UniProt",
"payload": {
"accession": "Q6V0I7",
"sequence": "MDLAPDRATGRPWLPLHTLSVSQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPV... | [
{
"source_db": "STRING",
"source_id": "FJX1",
"text": "FAT4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FJX1",
"confidence": 0.928
}
] | {
"protein": "FAT4",
"threshold": 700,
"partner_count": 3
} | 0.928 |
co_inte_00139 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ESR1 have with a combined association score ≥ 400? | ESR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SRC | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "STRING",
"source_id": "SRC",
"text": "ESR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SRC",
"confidence": 0.999
}
] | {
"protein": "ESR1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00140 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDK12 have with a combined association score ≥ 700? | CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK12",
"source_node_type": "GENE",
"source_node_label": "CDK12",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK12",
"source_db": "UniProt",
"payload": {
"accession": "Q9NYV4",
"sequence": "MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKS... | [
{
"source_db": "STRING",
"source_id": "CCNK",
"text": "CDK12 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNK",
"confidence": 0.999
}
] | {
"protein": "CDK12",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00141 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does TBK1 have with a combined association score ≥ 400? | TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3 | {
"steps": [
{
"hop": 1,
"source_node_id": "TBK1",
"source_node_type": "GENE",
"source_node_label": "TBK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "STRING",
"source_id": "IRF3",
"text": "TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3",
"confidence": 0.999
}
] | {
"protein": "TBK1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00142 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFP have with a combined association score ≥ 400? | AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFP",
"source_node_type": "GENE",
"source_node_label": "AFP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.973,
"edge_source_db": "STRING",
"tar... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFP",
"source_db": "UniProt",
"payload": {
"accession": "P02771",
"sequence": "MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPAS... | [
{
"source_db": "STRING",
"source_id": "F2",
"text": "AFP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH F2",
"confidence": 0.973
}
] | {
"protein": "AFP",
"threshold": 400,
"partner_count": 10
} | 0.973 |
co_inte_00143 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACKR3 have with a combined association score ≥ 900? | ACKR3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CXCL12 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACKR3",
"source_node_type": "GENE",
"source_node_label": "ACKR3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 7",
"B. 5",
"C. 4",
"D. 6"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACKR3",
"source_db": "UniProt",
"payload": {
"accession": "P25106",
"sequence": "MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIF... | [
{
"source_db": "STRING",
"source_id": "CXCL12",
"text": "ACKR3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CXCL12",
"confidence": 0.999
}
] | {
"protein": "ACKR3",
"threshold": 900,
"partner_count": 6
} | 0.999 |
co_inte_00144 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CFAP410 have with a combined association score ≥ 400? | CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CFAP410",
"source_node_type": "GENE",
"source_node_label": "CFAP410",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.982,
"edge_source_db": "STRING",
... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CFAP410",
"source_db": "UniProt",
"payload": {
"accession": "O43822",
"sequence": "MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEEL... | [
{
"source_db": "STRING",
"source_id": "NEK1",
"text": "CFAP410 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NEK1",
"confidence": 0.982
}
] | {
"protein": "CFAP410",
"threshold": 400,
"partner_count": 10
} | 0.982 |
co_inte_00145 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CBL have with a combined association score ≥ 900? | CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "STRING",
"source_id": "MET",
"text": "CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET",
"confidence": 0.999
}
] | {
"protein": "CBL",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00146 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ADORA2A have with a combined association score ≥ 900? | ADORA2A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DRD2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ADORA2A",
"source_node_type": "GENE",
"source_node_label": "ADORA2A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.997,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ADORA2A",
"source_db": "UniProt",
"payload": {
"accession": "P29274",
"sequence": "MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL... | [
{
"source_db": "STRING",
"source_id": "DRD2",
"text": "ADORA2A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DRD2",
"confidence": 0.997
}
] | {
"protein": "ADORA2A",
"threshold": 900,
"partner_count": 10
} | 0.997 |
co_inte_00147 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does APH1B have with a combined association score ≥ 400? | APH1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCSTN | {
"steps": [
{
"hop": 1,
"source_node_id": "APH1B",
"source_node_type": "GENE",
"source_node_label": "APH1B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 8",
"B. 10",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APH1B",
"source_db": "UniProt",
"payload": {
"accession": "Q8WW43",
"sequence": "MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSF... | [
{
"source_db": "STRING",
"source_id": "NCSTN",
"text": "APH1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCSTN",
"confidence": 0.999
}
] | {
"protein": "APH1B",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00148 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KMT2D have with a combined association score ≥ 900? | KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5 | {
"steps": [
{
"hop": 1,
"source_node_id": "KMT2D",
"source_node_type": "GENE",
"source_node_label": "KMT2D",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KMT2D",
"source_db": "UniProt",
"payload": {
"accession": "O14686",
"sequence": "MDSQKLAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPRLQETPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGFPEGLTPAHLGEPG... | [
{
"source_db": "STRING",
"source_id": "WDR5",
"text": "KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5",
"confidence": 0.999
}
] | {
"protein": "KMT2D",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00149 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CBL have with a combined association score ≥ 700? | CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "STRING",
"source_id": "MET",
"text": "CBL PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MET",
"confidence": 0.999
}
] | {
"protein": "CBL",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00150 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DCTN4 have with a combined association score ≥ 700? | DCTN4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6 | {
"steps": [
{
"hop": 1,
"source_node_id": "DCTN4",
"source_node_type": "GENE",
"source_node_label": "DCTN4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DCTN4",
"source_db": "UniProt",
"payload": {
"accession": "Q9UJW0",
"sequence": "MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGW... | [
{
"source_db": "STRING",
"source_id": "DCTN6",
"text": "DCTN4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DCTN6",
"confidence": 0.999
}
] | {
"protein": "DCTN4",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00151 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does HAP1 have with a combined association score ≥ 400? | HAP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HTT | {
"steps": [
{
"hop": 1,
"source_node_id": "HAP1",
"source_node_type": "GENE",
"source_node_label": "HAP1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HAP1",
"source_db": "UniProt",
"payload": {
"accession": "P54257",
"sequence": "MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQFLSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIWKTPAA... | [
{
"source_db": "STRING",
"source_id": "HTT",
"text": "HAP1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HTT",
"confidence": 0.999
}
] | {
"protein": "HAP1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00152 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AVPR1A have with a combined association score ≥ 700? | AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP | {
"steps": [
{
"hop": 1,
"source_node_id": "AVPR1A",
"source_node_type": "GENE",
"source_node_label": "AVPR1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AVPR1A",
"source_db": "UniProt",
"payload": {
"accession": "P37288",
"sequence": "MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQV... | [
{
"source_db": "STRING",
"source_id": "AVP",
"text": "AVPR1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AVP",
"confidence": 0.999
}
] | {
"protein": "AVPR1A",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00153 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does LRRK2 have with a combined association score ≥ 400? | LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29 | {
"steps": [
{
"hop": 1,
"source_node_id": "LRRK2",
"source_node_type": "GENE",
"source_node_label": "LRRK2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.995,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "STRING",
"source_id": "RAB29",
"text": "LRRK2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAB29",
"confidence": 0.995
}
] | {
"protein": "LRRK2",
"threshold": 400,
"partner_count": 10
} | 0.995 |
co_inte_00154 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD68 have with a combined association score ≥ 900? | CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD68",
"source_node_type": "GENE",
"source_node_label": "CD68",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.922,
"edge_source_db": "STRING",
"t... | B | [
"A. 7",
"B. 6",
"C. 4",
"D. 5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD68",
"source_db": "UniProt",
"payload": {
"accession": "P34810",
"sequence": "MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGF... | [
{
"source_db": "STRING",
"source_id": "LAMP3",
"text": "CD68 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH LAMP3",
"confidence": 0.922
}
] | {
"protein": "CD68",
"threshold": 900,
"partner_count": 6
} | 0.922 |
co_inte_00155 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PPP1R1B have with a combined association score ≥ 900? | PPP1R1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5 | {
"steps": [
{
"hop": 1,
"source_node_id": "PPP1R1B",
"source_node_type": "GENE",
"source_node_label": "PPP1R1B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.976,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PPP1R1B",
"source_db": "UniProt",
"payload": {
"accession": "Q9UD71",
"sequence": "MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEE... | [
{
"source_db": "STRING",
"source_id": "CDK5",
"text": "PPP1R1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5",
"confidence": 0.976
}
] | {
"protein": "PPP1R1B",
"threshold": 900,
"partner_count": 10
} | 0.976 |
co_inte_00156 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PALB2 have with a combined association score ≥ 700? | PALB2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51 | {
"steps": [
{
"hop": 1,
"source_node_id": "PALB2",
"source_node_type": "GENE",
"source_node_label": "PALB2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PALB2",
"source_db": "UniProt",
"payload": {
"accession": "Q86YC2",
"sequence": "MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQQDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQRTDDTQEHFPHRVS... | [
{
"source_db": "STRING",
"source_id": "RAD51",
"text": "PALB2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51",
"confidence": 0.999
}
] | {
"protein": "PALB2",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00157 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASP2 have with a combined association score ≥ 900? | CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASP2",
"source_node_type": "GENE",
"source_node_label": "CASP2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 6",
"B. 4",
"C. 7",
"D. 5"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP2",
"source_db": "UniProt",
"payload": {
"accession": "P42575",
"sequence": "MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLS... | [
{
"source_db": "STRING",
"source_id": "PIDD1",
"text": "CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1",
"confidence": 0.999
}
] | {
"protein": "CASP2",
"threshold": 900,
"partner_count": 6
} | 0.999 |
co_inte_00158 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KRAS have with a combined association score ≥ 700? | KRAS PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RALGDS | {
"steps": [
{
"hop": 1,
"source_node_id": "KRAS",
"source_node_type": "GENE",
"source_node_label": "KRAS",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KRAS",
"source_db": "UniProt",
"payload": {
"accession": "P01116",
"sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLA... | [
{
"source_db": "STRING",
"source_id": "RALGDS",
"text": "KRAS PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RALGDS",
"confidence": 0.999
}
] | {
"protein": "KRAS",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00159 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does POLD1 have with a combined association score ≥ 900? | POLD1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH POLD4 | {
"steps": [
{
"hop": 1,
"source_node_id": "POLD1",
"source_node_type": "GENE",
"source_node_label": "POLD1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "POLD1",
"source_db": "UniProt",
"payload": {
"accession": "P28340",
"sequence": "MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAFGVTDE... | [
{
"source_db": "STRING",
"source_id": "POLD4",
"text": "POLD1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH POLD4",
"confidence": 0.999
}
] | {
"protein": "POLD1",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00160 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KMT2D have with a combined association score ≥ 700? | KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5 | {
"steps": [
{
"hop": 1,
"source_node_id": "KMT2D",
"source_node_type": "GENE",
"source_node_label": "KMT2D",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 9",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KMT2D",
"source_db": "UniProt",
"payload": {
"accession": "O14686",
"sequence": "MDSQKLAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPRLQETPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGFPEGLTPAHLGEPG... | [
{
"source_db": "STRING",
"source_id": "WDR5",
"text": "KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5",
"confidence": 0.999
}
] | {
"protein": "KMT2D",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00161 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does APP have with a combined association score ≥ 900? | APP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "APP",
"source_node_type": "GENE",
"source_node_label": "APP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | C | [
"A. 8",
"B. 11",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "STRING",
"source_id": "SORL1",
"text": "APP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORL1",
"confidence": 0.999
}
] | {
"protein": "APP",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00162 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACHE have with a combined association score ≥ 700? | ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH COLQ | {
"steps": [
{
"hop": 1,
"source_node_id": "ACHE",
"source_node_type": "GENE",
"source_node_label": "ACHE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.989,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACHE",
"source_db": "UniProt",
"payload": {
"accession": "P22303",
"sequence": "MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWT... | [
{
"source_db": "STRING",
"source_id": "COLQ",
"text": "ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH COLQ",
"confidence": 0.989
}
] | {
"protein": "ACHE",
"threshold": 700,
"partner_count": 10
} | 0.989 |
co_inte_00163 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ERBB4 have with a combined association score ≥ 700? | ERBB4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ERBB3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ERBB4",
"source_node_type": "GENE",
"source_node_label": "ERBB4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB4",
"source_db": "UniProt",
"payload": {
"accession": "Q15303",
"sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQE... | [
{
"source_db": "STRING",
"source_id": "ERBB3",
"text": "ERBB4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ERBB3",
"confidence": 0.999
}
] | {
"protein": "ERBB4",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00164 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does IL17A have with a combined association score ≥ 400? | IL17A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IL17RA | {
"steps": [
{
"hop": 1,
"source_node_id": "IL17A",
"source_node_type": "GENE",
"source_node_label": "IL17A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "IL17A",
"source_db": "UniProt",
"payload": {
"accession": "Q16552",
"sequence": "MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSF... | [
{
"source_db": "STRING",
"source_id": "IL17RA",
"text": "IL17A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IL17RA",
"confidence": 0.999
}
] | {
"protein": "IL17A",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00165 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACE have with a combined association score ≥ 400? | ACE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AGT | {
"steps": [
{
"hop": 1,
"source_node_id": "ACE",
"source_node_type": "GENE",
"source_node_label": "ACE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACE",
"source_db": "UniProt",
"payload": {
"accession": "P12821",
"sequence": "MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLA... | [
{
"source_db": "STRING",
"source_id": "AGT",
"text": "ACE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AGT",
"confidence": 0.999
}
] | {
"protein": "ACE",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00166 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BRAF have with a combined association score ≥ 700? | BRAF PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH YWHAZ | {
"steps": [
{
"hop": 1,
"source_node_id": "BRAF",
"source_node_type": "GENE",
"source_node_label": "BRAF",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRAF",
"source_db": "UniProt",
"payload": {
"accession": "P15056",
"sequence": "MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSS... | [
{
"source_db": "STRING",
"source_id": "YWHAZ",
"text": "BRAF PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH YWHAZ",
"confidence": 0.999
}
] | {
"protein": "BRAF",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00167 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CSF1R have with a combined association score ≥ 700? | CSF1R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CSF1R",
"source_node_type": "GENE",
"source_node_label": "CSF1R",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 8",
"B. 10",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CSF1R",
"source_db": "UniProt",
"payload": {
"accession": "P07333",
"sequence": "MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPV... | [
{
"source_db": "STRING",
"source_id": "CSF1",
"text": "CSF1R PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CSF1",
"confidence": 0.999
}
] | {
"protein": "CSF1R",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00168 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD274 have with a combined association score ≥ 400? | CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD274",
"source_node_type": "GENE",
"source_node_label": "CD274",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD274",
"source_db": "UniProt",
"payload": {
"accession": "Q9NZQ7",
"sequence": "MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAP... | [
{
"source_db": "STRING",
"source_id": "CD80",
"text": "CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80",
"confidence": 0.999
}
] | {
"protein": "CD274",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00169 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACVR1B have with a combined association score ≥ 900? | ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B | {
"steps": [
{
"hop": 1,
"source_node_id": "ACVR1B",
"source_node_type": "GENE",
"source_node_label": "ACVR1B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1B",
"source_db": "UniProt",
"payload": {
"accession": "P36896",
"sequence": "MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIA... | [
{
"source_db": "STRING",
"source_id": "ACVR2B",
"text": "ACVR1B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ACVR2B",
"confidence": 0.999
}
] | {
"protein": "ACVR1B",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00170 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CA9 have with a combined association score ≥ 400? | CA9 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HIF1A | {
"steps": [
{
"hop": 1,
"source_node_id": "CA9",
"source_node_type": "GENE",
"source_node_label": "CA9",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.944,
"edge_source_db": "STRING",
"tar... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CA9",
"source_db": "UniProt",
"payload": {
"accession": "Q16790",
"sequence": "MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEG... | [
{
"source_db": "STRING",
"source_id": "HIF1A",
"text": "CA9 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HIF1A",
"confidence": 0.944
}
] | {
"protein": "CA9",
"threshold": 400,
"partner_count": 10
} | 0.944 |
co_inte_00171 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FBXO7 have with a combined association score ≥ 400? | FBXO7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SKP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "FBXO7",
"source_node_type": "GENE",
"source_node_label": "FBXO7",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.997,
"edge_source_db": "STRING",
... | B | [
"A. 11",
"B. 10",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FBXO7",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y3I1",
"sequence": "MRLRVRLLKRTWPLEVPETEPTLGHLRSHLRQSLLCTWGYSSNTRFTITLNYKDPLTGDEETLASYGIVSGDLICLILQDDIPAPNIPSSTDSEHSSLQNNEQPSLATSSNQTSMQDEQPSDSFQGQAAQSGV... | [
{
"source_db": "STRING",
"source_id": "SKP1",
"text": "FBXO7 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SKP1",
"confidence": 0.997
}
] | {
"protein": "FBXO7",
"threshold": 400,
"partner_count": 10
} | 0.997 |
co_inte_00172 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ABI1 have with a combined association score ≥ 700? | ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABI1",
"source_node_type": "GENE",
"source_node_label": "ABI1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 8",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABI1",
"source_db": "UniProt",
"payload": {
"accession": "Q8IZP0",
"sequence": "MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPV... | [
{
"source_db": "STRING",
"source_id": "WASF2",
"text": "ABI1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WASF2",
"confidence": 0.999
}
] | {
"protein": "ABI1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00173 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MAPT have with a combined association score ≥ 900? | MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5 | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPT",
"source_node_type": "GENE",
"source_node_label": "MAPT",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPT",
"source_db": "UniProt",
"payload": {
"accession": "P10636",
"sequence": "MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQE... | [
{
"source_db": "STRING",
"source_id": "CDK5",
"text": "MAPT PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CDK5",
"confidence": 0.999
}
] | {
"protein": "MAPT",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00174 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASP2 have with a combined association score ≥ 400? | CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASP2",
"source_node_type": "GENE",
"source_node_label": "CASP2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASP2",
"source_db": "UniProt",
"payload": {
"accession": "P42575",
"sequence": "MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLS... | [
{
"source_db": "STRING",
"source_id": "PIDD1",
"text": "CASP2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PIDD1",
"confidence": 0.999
}
] | {
"protein": "CASP2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00175 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACHE have with a combined association score ≥ 700? | ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH COLQ | {
"steps": [
{
"hop": 1,
"source_node_id": "ACHE",
"source_node_type": "GENE",
"source_node_label": "ACHE",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.989,
"edge_source_db": "STRING",
"t... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACHE",
"source_db": "UniProt",
"payload": {
"accession": "P22303",
"sequence": "MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWT... | [
{
"source_db": "STRING",
"source_id": "COLQ",
"text": "ACHE PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH COLQ",
"confidence": 0.989
}
] | {
"protein": "ACHE",
"threshold": 700,
"partner_count": 10
} | 0.989 |
co_inte_00176 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KLK3 have with a combined association score ≥ 700? | KLK3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SERPINA3 | {
"steps": [
{
"hop": 1,
"source_node_id": "KLK3",
"source_node_type": "GENE",
"source_node_label": "KLK3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.995,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KLK3",
"source_db": "UniProt",
"payload": {
"accession": "P07288",
"sequence": "MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTD... | [
{
"source_db": "STRING",
"source_id": "SERPINA3",
"text": "KLK3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SERPINA3",
"confidence": 0.995
}
] | {
"protein": "KLK3",
"threshold": 700,
"partner_count": 10
} | 0.995 |
co_inte_00177 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD33 have with a combined association score ≥ 400? | CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A | {
"steps": [
{
"hop": 1,
"source_node_id": "CD33",
"source_node_type": "GENE",
"source_node_label": "CD33",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.974,
"edge_source_db": "STRING",
"t... | B | [
"A. 11",
"B. 10",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD33",
"source_db": "UniProt",
"payload": {
"accession": "P20138",
"sequence": "MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQL... | [
{
"source_db": "STRING",
"source_id": "FCGR3A",
"text": "CD33 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FCGR3A",
"confidence": 0.974
}
] | {
"protein": "CD33",
"threshold": 400,
"partner_count": 10
} | 0.974 |
co_inte_00178 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BIRC5 have with a combined association score ≥ 900? | BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "BIRC5",
"source_node_type": "GENE",
"source_node_label": "BIRC5",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIRC5",
"source_db": "UniProt",
"payload": {
"accession": "O15392",
"sequence": "MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRR... | [
{
"source_db": "STRING",
"source_id": "AURKB",
"text": "BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB",
"confidence": 0.999
}
] | {
"protein": "BIRC5",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00179 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CHMP2B have with a combined association score ≥ 900? | CHMP2B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH VPS4B | {
"steps": [
{
"hop": 1,
"source_node_id": "CHMP2B",
"source_node_type": "GENE",
"source_node_label": "CHMP2B",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.998,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CHMP2B",
"source_db": "UniProt",
"payload": {
"accession": "Q9UQN3",
"sequence": "MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKEN... | [
{
"source_db": "STRING",
"source_id": "VPS4B",
"text": "CHMP2B PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH VPS4B",
"confidence": 0.998
}
] | {
"protein": "CHMP2B",
"threshold": 900,
"partner_count": 10
} | 0.998 |
co_inte_00180 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does APP have with a combined association score ≥ 700? | APP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "APP",
"source_node_type": "GENE",
"source_node_label": "APP",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"tar... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "STRING",
"source_id": "SORL1",
"text": "APP PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORL1",
"confidence": 0.999
}
] | {
"protein": "APP",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00181 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PINK1 have with a combined association score ≥ 400? | PINK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PRKN | {
"steps": [
{
"hop": 1,
"source_node_id": "PINK1",
"source_node_type": "GENE",
"source_node_label": "PINK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PINK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9BXM7",
"sequence": "MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQAIFT... | [
{
"source_db": "STRING",
"source_id": "PRKN",
"text": "PINK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PRKN",
"confidence": 0.999
}
] | {
"protein": "PINK1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00182 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CASS4 have with a combined association score ≥ 400? | CASS4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NME8 | {
"steps": [
{
"hop": 1,
"source_node_id": "CASS4",
"source_node_type": "GENE",
"source_node_label": "CASS4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.814,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 11",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASS4",
"source_db": "UniProt",
"payload": {
"accession": "Q9NQ75",
"sequence": "MKGTGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEF... | [
{
"source_db": "STRING",
"source_id": "NME8",
"text": "CASS4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NME8",
"confidence": 0.814
}
] | {
"protein": "CASS4",
"threshold": 400,
"partner_count": 10
} | 0.814 |
co_inte_00183 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PDE10A have with a combined association score ≥ 900? | PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "PDE10A",
"source_node_type": "GENE",
"source_node_label": "PDE10A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.934,
"edge_source_db": "STRING",
... | D | [
"A. 11",
"B. 8",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PDE10A",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y233",
"sequence": "MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPS... | [
{
"source_db": "STRING",
"source_id": "ENPP3",
"text": "PDE10A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ENPP3",
"confidence": 0.934
}
] | {
"protein": "PDE10A",
"threshold": 900,
"partner_count": 10
} | 0.934 |
co_inte_00184 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does DNAJC6 have with a combined association score ≥ 900? | DNAJC6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSPA8 | {
"steps": [
{
"hop": 1,
"source_node_id": "DNAJC6",
"source_node_type": "GENE",
"source_node_label": "DNAJC6",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 6",
"B. 4",
"C. 5",
"D. 3"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DNAJC6",
"source_db": "UniProt",
"payload": {
"accession": "O75061",
"sequence": "MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPI... | [
{
"source_db": "STRING",
"source_id": "HSPA8",
"text": "DNAJC6 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH HSPA8",
"confidence": 0.999
}
] | {
"protein": "DNAJC6",
"threshold": 900,
"partner_count": 5
} | 0.999 |
co_inte_00185 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does GRN have with a combined association score ≥ 700? | GRN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "GRN",
"source_node_type": "GENE",
"source_node_label": "GRN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.968,
"edge_source_db": "STRING",
"tar... | B | [
"A. 8",
"B. 10",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "GRN",
"source_db": "UniProt",
"payload": {
"accession": "P28799",
"sequence": "MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPD... | [
{
"source_db": "STRING",
"source_id": "SORT1",
"text": "GRN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SORT1",
"confidence": 0.968
}
] | {
"protein": "GRN",
"threshold": 700,
"partner_count": 10
} | 0.968 |
co_inte_00186 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PTEN have with a combined association score ≥ 400? | PTEN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "PTEN",
"source_node_type": "GENE",
"source_node_label": "PTEN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "STRING",
"source_id": "TP53",
"text": "PTEN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH TP53",
"confidence": 0.999
}
] | {
"protein": "PTEN",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00187 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AKT2 have with a combined association score ≥ 400? | AKT2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PHLPP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT2",
"source_node_type": "GENE",
"source_node_label": "AKT2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.994,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 9",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT2",
"source_db": "UniProt",
"payload": {
"accession": "P31751",
"sequence": "MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTE... | [
{
"source_db": "STRING",
"source_id": "PHLPP1",
"text": "AKT2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PHLPP1",
"confidence": 0.994
}
] | {
"protein": "AKT2",
"threshold": 400,
"partner_count": 10
} | 0.994 |
co_inte_00188 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BRAF have with a combined association score ≥ 400? | BRAF PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH YWHAZ | {
"steps": [
{
"hop": 1,
"source_node_id": "BRAF",
"source_node_type": "GENE",
"source_node_label": "BRAF",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRAF",
"source_db": "UniProt",
"payload": {
"accession": "P15056",
"sequence": "MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSS... | [
{
"source_db": "STRING",
"source_id": "YWHAZ",
"text": "BRAF PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH YWHAZ",
"confidence": 0.999
}
] | {
"protein": "BRAF",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00189 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PRKN have with a combined association score ≥ 900? | PRKN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP | {
"steps": [
{
"hop": 1,
"source_node_id": "PRKN",
"source_node_type": "GENE",
"source_node_label": "PRKN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PRKN",
"source_db": "UniProt",
"payload": {
"accession": "O60260",
"sequence": "MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPA... | [
{
"source_db": "STRING",
"source_id": "SNCAIP",
"text": "PRKN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNCAIP",
"confidence": 0.999
}
] | {
"protein": "PRKN",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00190 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MLH1 have with a combined association score ≥ 400? | MLH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MLH3 | {
"steps": [
{
"hop": 1,
"source_node_id": "MLH1",
"source_node_type": "GENE",
"source_node_label": "MLH1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 11",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MLH1",
"source_db": "UniProt",
"payload": {
"accession": "P40692",
"sequence": "MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGK... | [
{
"source_db": "STRING",
"source_id": "MLH3",
"text": "MLH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MLH3",
"confidence": 0.999
}
] | {
"protein": "MLH1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00191 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PMS2 have with a combined association score ≥ 400? | PMS2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MSH6 | {
"steps": [
{
"hop": 1,
"source_node_id": "PMS2",
"source_node_type": "GENE",
"source_node_label": "PMS2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 11",
"B. 10",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PMS2",
"source_db": "UniProt",
"payload": {
"accession": "P54278",
"sequence": "MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR... | [
{
"source_db": "STRING",
"source_id": "MSH6",
"text": "PMS2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MSH6",
"confidence": 0.999
}
] | {
"protein": "PMS2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00192 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD274 have with a combined association score ≥ 900? | CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80 | {
"steps": [
{
"hop": 1,
"source_node_id": "CD274",
"source_node_type": "GENE",
"source_node_label": "CD274",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD274",
"source_db": "UniProt",
"payload": {
"accession": "Q9NZQ7",
"sequence": "MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAP... | [
{
"source_db": "STRING",
"source_id": "CD80",
"text": "CD274 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CD80",
"confidence": 0.999
}
] | {
"protein": "CD274",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00193 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does TBK1 have with a combined association score ≥ 400? | TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3 | {
"steps": [
{
"hop": 1,
"source_node_id": "TBK1",
"source_node_type": "GENE",
"source_node_label": "TBK1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 8",
"B. 10",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "STRING",
"source_id": "IRF3",
"text": "TBK1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH IRF3",
"confidence": 0.999
}
] | {
"protein": "TBK1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00194 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ATP6V1A have with a combined association score ≥ 900? | ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1A",
"source_node_type": "GENE",
"source_node_label": "ATP6V1A",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 11",
"B. 10",
"C. 8",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1A",
"source_db": "UniProt",
"payload": {
"accession": "P38606",
"sequence": "MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDI... | [
{
"source_db": "STRING",
"source_id": "ATP6V0A1",
"text": "ATP6V1A PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH ATP6V0A1",
"confidence": 0.999
}
] | {
"protein": "ATP6V1A",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00195 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does NOTCH1 have with a combined association score ≥ 400? | NOTCH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DLL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "NOTCH1",
"source_node_type": "GENE",
"source_node_label": "NOTCH1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NOTCH1",
"source_db": "UniProt",
"payload": {
"accession": "P46531",
"sequence": "MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG... | [
{
"source_db": "STRING",
"source_id": "DLL1",
"text": "NOTCH1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH DLL1",
"confidence": 0.999
}
] | {
"protein": "NOTCH1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00196 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CDK4 have with a combined association score ≥ 900? | CDK4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK4",
"source_node_type": "GENE",
"source_node_label": "CDK4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 8",
"C. 9",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK4",
"source_db": "UniProt",
"payload": {
"accession": "P11802",
"sequence": "MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN... | [
{
"source_db": "STRING",
"source_id": "CCNL2",
"text": "CDK4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CCNL2",
"confidence": 0.999
}
] | {
"protein": "CDK4",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00197 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ETV4 have with a combined association score ≥ 900? | ETV4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCOA3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ETV4",
"source_node_type": "GENE",
"source_node_label": "ETV4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.963,
"edge_source_db": "STRING",
"t... | C | [
"A. 0",
"B. 2",
"C. 1",
"D. 0"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ETV4",
"source_db": "UniProt",
"payload": {
"accession": "P43268",
"sequence": "MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPR... | [
{
"source_db": "STRING",
"source_id": "NCOA3",
"text": "ETV4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCOA3",
"confidence": 0.963
}
] | {
"protein": "ETV4",
"threshold": 900,
"partner_count": 1
} | 0.963 |
co_inte_00198 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BST1 have with a combined association score ≥ 900? | BST1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NMNAT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BST1",
"source_node_type": "GENE",
"source_node_label": "BST1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.96,
"edge_source_db": "STRING",
"ta... | B | [
"A. 9",
"B. 10",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BST1",
"source_db": "UniProt",
"payload": {
"accession": "Q10588",
"sequence": "MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLY... | [
{
"source_db": "STRING",
"source_id": "NMNAT1",
"text": "BST1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NMNAT1",
"confidence": 0.96
}
] | {
"protein": "BST1",
"threshold": 900,
"partner_count": 10
} | 0.96 |
co_inte_00199 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does PALB2 have with a combined association score ≥ 400? | PALB2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51 | {
"steps": [
{
"hop": 1,
"source_node_id": "PALB2",
"source_node_type": "GENE",
"source_node_label": "PALB2",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PALB2",
"source_db": "UniProt",
"payload": {
"accession": "Q86YC2",
"sequence": "MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQQDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQRTDDTQEHFPHRVS... | [
{
"source_db": "STRING",
"source_id": "RAD51",
"text": "PALB2 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RAD51",
"confidence": 0.999
}
] | {
"protein": "PALB2",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00200 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CD44 have with a combined association score ≥ 900? | CD44 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RDX | {
"steps": [
{
"hop": 1,
"source_node_id": "CD44",
"source_node_type": "GENE",
"source_node_label": "CD44",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD44",
"source_db": "UniProt",
"payload": {
"accession": "P16070",
"sequence": "MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTD... | [
{
"source_db": "STRING",
"source_id": "RDX",
"text": "CD44 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RDX",
"confidence": 0.999
}
] | {
"protein": "CD44",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00201 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does EGFR have with a combined association score ≥ 400? | EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "STRING",
"source_id": "PTPN11",
"text": "EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11",
"confidence": 0.999
}
] | {
"protein": "EGFR",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00202 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does MLH3 have with a combined association score ≥ 700? | MLH3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MSH6 | {
"steps": [
{
"hop": 1,
"source_node_id": "MLH3",
"source_node_type": "GENE",
"source_node_label": "MLH3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | B | [
"A. 9",
"B. 10",
"C. 11",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MLH3",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHC1",
"sequence": "MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACE... | [
{
"source_db": "STRING",
"source_id": "MSH6",
"text": "MLH3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH MSH6",
"confidence": 0.999
}
] | {
"protein": "MLH3",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00203 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does FGFR1 have with a combined association score ≥ 700? | FGFR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FGF18 | {
"steps": [
{
"hop": 1,
"source_node_id": "FGFR1",
"source_node_type": "GENE",
"source_node_label": "FGFR1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 9",
"B. 8",
"C. 11",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FGFR1",
"source_db": "UniProt",
"payload": {
"accession": "P11362",
"sequence": "MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDD... | [
{
"source_db": "STRING",
"source_id": "FGF18",
"text": "FGFR1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH FGF18",
"confidence": 0.999
}
] | {
"protein": "FGFR1",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00204 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BCOR have with a combined association score ≥ 400? | BCOR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PCGF1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BCOR",
"source_node_type": "GENE",
"source_node_label": "BCOR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCOR",
"source_db": "UniProt",
"payload": {
"accession": "Q6W2J9",
"sequence": "MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEA... | [
{
"source_db": "STRING",
"source_id": "PCGF1",
"text": "BCOR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PCGF1",
"confidence": 0.999
}
] | {
"protein": "BCOR",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00205 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does REST have with a combined association score ≥ 400? | REST PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RCOR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "REST",
"source_node_type": "GENE",
"source_node_label": "REST",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | A | [
"A. 10",
"B. 11",
"C. 9",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "REST",
"source_db": "UniProt",
"payload": {
"accession": "Q13127",
"sequence": "MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVEPQPVFEASGAPDIY... | [
{
"source_db": "STRING",
"source_id": "RCOR1",
"text": "REST PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH RCOR1",
"confidence": 0.999
}
] | {
"protein": "REST",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00206 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BIRC5 have with a combined association score ≥ 400? | BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "BIRC5",
"source_node_type": "GENE",
"source_node_label": "BIRC5",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 9",
"B. 8",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BIRC5",
"source_db": "UniProt",
"payload": {
"accession": "O15392",
"sequence": "MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRR... | [
{
"source_db": "STRING",
"source_id": "AURKB",
"text": "BIRC5 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH AURKB",
"confidence": 0.999
}
] | {
"protein": "BIRC5",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00207 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does VPS35 have with a combined association score ≥ 700? | VPS35 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNX5 | {
"steps": [
{
"hop": 1,
"source_node_id": "VPS35",
"source_node_type": "GENE",
"source_node_label": "VPS35",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 8",
"C. 10",
"D. 9"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VPS35",
"source_db": "UniProt",
"payload": {
"accession": "Q96QK1",
"sequence": "MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDL... | [
{
"source_db": "STRING",
"source_id": "SNX5",
"text": "VPS35 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SNX5",
"confidence": 0.999
}
] | {
"protein": "VPS35",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00208 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AURKB have with a combined association score ≥ 700? | AURKB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BUB1B | {
"steps": [
{
"hop": 1,
"source_node_id": "AURKB",
"source_node_type": "GENE",
"source_node_label": "AURKB",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | D | [
"A. 8",
"B. 11",
"C. 9",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKB",
"source_db": "UniProt",
"payload": {
"accession": "Q96GD4",
"sequence": "MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH... | [
{
"source_db": "STRING",
"source_id": "BUB1B",
"text": "AURKB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BUB1B",
"confidence": 0.999
}
] | {
"protein": "AURKB",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00209 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ETV4 have with a combined association score ≥ 900? | ETV4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCOA3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ETV4",
"source_node_type": "GENE",
"source_node_label": "ETV4",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.963,
"edge_source_db": "STRING",
"t... | D | [
"A. 0",
"B. 2",
"C. 0",
"D. 1"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ETV4",
"source_db": "UniProt",
"payload": {
"accession": "P43268",
"sequence": "MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPR... | [
{
"source_db": "STRING",
"source_id": "NCOA3",
"text": "ETV4 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NCOA3",
"confidence": 0.963
}
] | {
"protein": "ETV4",
"threshold": 900,
"partner_count": 1
} | 0.963 |
co_inte_00210 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does EGFR have with a combined association score ≥ 700? | EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | D | [
"A. 11",
"B. 9",
"C. 8",
"D. 10"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "STRING",
"source_id": "PTPN11",
"text": "EGFR PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PTPN11",
"confidence": 0.999
}
] | {
"protein": "EGFR",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00211 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does BNIP3 have with a combined association score ≥ 400? | BNIP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BCL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "BNIP3",
"source_node_type": "GENE",
"source_node_label": "BNIP3",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 9",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BNIP3",
"source_db": "UniProt",
"payload": {
"accession": "Q12983",
"sequence": "MSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFL... | [
{
"source_db": "STRING",
"source_id": "BCL2",
"text": "BNIP3 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH BCL2",
"confidence": 0.999
}
] | {
"protein": "BNIP3",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00212 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does SYNJ1 have with a combined association score ≥ 400? | SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SYNJ1",
"source_node_type": "GENE",
"source_node_label": "SYNJ1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.998,
"edge_source_db": "STRING",
... | C | [
"A. 8",
"B. 9",
"C. 10",
"D. 11"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SYNJ1",
"source_db": "UniProt",
"payload": {
"accession": "O43426",
"sequence": "MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWS... | [
{
"source_db": "STRING",
"source_id": "SH3GL2",
"text": "SYNJ1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH SH3GL2",
"confidence": 0.998
}
] | {
"protein": "SYNJ1",
"threshold": 400,
"partner_count": 10
} | 0.998 |
co_inte_00213 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does CTNNA1 have with a combined association score ≥ 400? | CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNA1",
"source_node_type": "GENE",
"source_node_label": "CTNNA1",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "STRING",
"source_id": "CTNNB1",
"text": "CTNNA1 PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH CTNNB1",
"confidence": 0.999
}
] | {
"protein": "CTNNA1",
"threshold": 400,
"partner_count": 10
} | 0.999 |
co_inte_00214 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does AFDN have with a combined association score ≥ 900? | AFDN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NECTIN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "AFDN",
"source_node_type": "GENE",
"source_node_label": "AFDN",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 9",
"B. 11",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AFDN",
"source_db": "UniProt",
"payload": {
"accession": "P55196",
"sequence": "MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDA... | [
{
"source_db": "STRING",
"source_id": "NECTIN3",
"text": "AFDN PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH NECTIN3",
"confidence": 0.999
}
] | {
"protein": "AFDN",
"threshold": 900,
"partner_count": 10
} | 0.999 |
co_inte_00215 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does KMT2D have with a combined association score ≥ 700? | KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5 | {
"steps": [
{
"hop": 1,
"source_node_id": "KMT2D",
"source_node_type": "GENE",
"source_node_label": "KMT2D",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
... | A | [
"A. 10",
"B. 9",
"C. 8",
"D. 11"
] | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KMT2D",
"source_db": "UniProt",
"payload": {
"accession": "O14686",
"sequence": "MDSQKLAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPRLQETPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGFPEGLTPAHLGEPG... | [
{
"source_db": "STRING",
"source_id": "WDR5",
"text": "KMT2D PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH WDR5",
"confidence": 0.999
}
] | {
"protein": "KMT2D",
"threshold": 700,
"partner_count": 10
} | 0.999 |
co_inte_00216 | interaction_propagation | coding_variant | easy | 1 | How many direct STRING interaction partners does ACTB have with a combined association score ≥ 400? | ACTB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PFN3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACTB",
"source_node_type": "GENE",
"source_node_label": "ACTB",
"edge_relation": "PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH",
"edge_evidence_type": "multi-channel",
"edge_confidence": 0.999,
"edge_source_db": "STRING",
"t... | C | [
"A. 11",
"B. 9",
"C. 10",
"D. 8"
] | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACTB",
"source_db": "UniProt",
"payload": {
"accession": "P60709",
"sequence": "MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYV... | [
{
"source_db": "STRING",
"source_id": "PFN3",
"text": "ACTB PROTEIN_FUNCTIONALLY_ASSOCIATED_WITH PFN3",
"confidence": 0.999
}
] | {
"protein": "ACTB",
"threshold": 400,
"partner_count": 10
} | 0.999 |
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