accession stringlengths 6 10 | name stringlengths 6 11 | Full Name stringlengths 1 147 ⌀ | taxon stringlengths 3 46 ⌀ | sequence stringlengths 16 2.75k | function stringlengths 6 5.51k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q47UU9 | EFTU_COLP3 | Elongation factor Tu | Colwellia | MAKEKFERNKPHVNVGTIGHVDHGKTTLTAAISAVLTKVHGGEVKDFAQIDNAPEERERGITINTSHIEYDTEARHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLSRQVGVPFIIVFMNKCDVVDDEELLELVEMEVRELLSEYDFPGDDLPVIQGSALGALQGDEAWEAKIIELADALDTYIPEPERAIDGAFIMPIEDVFSISGRGTVVTGRVERGIIKIGEEVEVVGIRDTQKSTCTGVEMFRKLLDEGRAGENCGVLLRGLKREDVERGQVLCAPGSILPHTKFESEVYVLSKDEGGRH... | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. | Q47UU9 |
A0A0D1E6B3 | PIT1_USTMA | Proteins important for tumors 1 | Ustilago | MERHDGEEYIPAIFGGQPPHASQVISLMKFSQETTTWNLPIMIAQALLVSEVIRTYPAELRMLHRLFQRKHPNMAEIFFILIKYLTIFAVIFDILVTETFAARTDFDCRSWAWTSSTFYFMCSTLVFCVIGWRARIIFRTSQVASWSLSVGLMGQFAVAMWTNYRVDKADALTPAGTCAPAAQVHADASQRNAALQLHFWQSSTFWFLLYNTIFESSILMACCIKLRKTSSGPSGLTKIAKVLFSNNVHYMAGVETCNVIELVMLLGWTSSLPPVHITSIAIQIVVGLQMLIGEQEAVYSPTCSQLSYSQYSSDSGGYIN... | Plasma membrane virulence factor required for spreading and inducing tumors in infected leaves. | A0A0D1E6B3 |
P62449 | HIS6_BACC1 | ImGP synthase subunit HisF | Bacillus cereus group | MLAKRVIPCLDVKEGRVVKGVNFIGLQDVGDPVEIAALYNDAGADEIVFLDITATHEGRKTIVDVVEKTASKVFIPLTVGGGISNVKDMYNLLRAGADKVSINSAAVRNPKLIGEGAEHFGSQCIVVAIDARKVAEDKWNVYVNGGRVDTGMDAIRWAKRVTELGAGEILLTSMDADGTKNGYDLRLTEEISKSVSVPVIASGGCGHADHIIEVFQKTAVDAALAASIFHYGEATIGDVKRKLRNANVEVRL | IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | P62449 |
A8FPE0 | TDH_SHESH | L-threonine 3-dehydrogenase | Shewanella | MKALSKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDIHIYNWDEWSQKTIPVPMVVGHEYVGEVIDMGIEVRGFDVGDRVSGEGHITCGHCRNCRGGRTHLCRNTSGVGVNRDGAFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELANKMGATRAVNVAKESLEGVMEELGMTEGFDVGLEMSGVPSAFHSMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLILKGIYGREMFETWYKMASLIQSGLDISPIITHHFKIDD... | Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. | A8FPE0 |
P49748 | ACADV_HUMAN | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | Homo | MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSE... | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats . The first step of fatty acid beta-oxidation consis... | P49748 |
Q7V8L0 | MURA_PROMM | UDP-N-acetylglucosamine enolpyruvyl transferase | Prochlorococcus | MPAAVSISQEILKPHLEIQGGHTLSRELKVSGAKNSALVLMTSALLSEGPLELHNVPQLTDIQGMADILASLGVRVKRSQETVWLQADGLHHAEPPYDLVNGLRASFFCIGPLLGRLGHAKVPLPGGCRIGARPVVEHIRGLKALGAMVKVEHGVVTASVPGTSRRLKGAAIVLDCPSVGATETILMAAVLAEGTSTIENAAQEPEVQDLAKMLNAMGARVSGAGGPIITIEGVERLHGCNYSVIPDRIEAGTFLIAAAITRSIVRVSPVIPEHLNAVLQKLRDCGCTLEIDKQGITLIPGDLHGVDIITQPFPGFPTDL... | Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. | Q7V8L0 |
P53700 | CCHL_CANAW | Cytochrome c heme lyase | Candida | MGWFWADKPSQDTVKATSSFTTPSACPIDHSKLASSSPTCPVKLNNDNDEVLNPLNNMPMAISSERAPGQRIKLSTERTISTIPRGESEDQGLWEYPSPQQMLNAMLSKGKGDGVPEDAVESMVEVHNFLNEGAWQQILTWEDQYTQQTKVEPRLKKFTGRPHDLSPKARMYLWLGQLFPETFNTIPPFDRHDWTVLRSCGRNQGWKEVRYVIDYYGAPDDEETGMPAFMLDTRPALDNLTNARDRFTHWAYPLWKKAMGEVRD | Lyase that probably catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. | P53700 |
A6LMR3 | COAX_THEM4 | Pantothenic acid kinase | Thermosipho | MKILFDVGNTHTTVALTENGKFFKIKRISTYSIQTEDELYAYLKVFFGETYDEVIVSSVVPNINHVFEFFSKKYAGKSAIFLNAQSYKGITWNVKIPSEIGADRVANIIAAERDYGKDAIVVDFGTAITIDILKEKSYEGGIIIPGFSMMINALFKGTAKLPKVELKPFNGFIGKDTESNIRIGIINTVVEGIGSVINKIKNENFRDVPVIFTGGQSKIIMDYKRDVIYDLELGLRGIYYFYESVVS | Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | A6LMR3 |
Q0AIH5 | IF1_NITEC | Translation initiation factor IF-1 | Nitrosomonas | MAKEETIQMQGEVIETLPNATFRIKLENGHIVLGHISGKMRMNYIRILPGDKVTVDLTPYDLTRARITFRTK | One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-... | Q0AIH5 |
P0CI71 | K0319_RAT | Dyslexia-associated protein KIAA0319 homolog | Rattus | MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNLESIRIMRVSHTFSVGDCTAACCDLPSCDLAWWFEGSCYLVNCMRPENCEPRTTGPIRSYLTFVRRPVQRSGQLLDYGDMMLGRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETAEYSDDYKELERGLLQPSNQQDPRGSAEYPDWSLLPSSDGDFNASATGDNSAASTEKLQDLTPYPLDQEQLQSLNESTWSPTPRHSEMSSMWPSSVTASPTEEGLEGEETLQLQEQPNNSSGKKVPMPSHNPSPASLESSPTTVEKSSIFTVTPWSRDPGTPTFPAS... | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. | P0CI71 |
Q58CN7 | CDKA2_BOVIN | DOC-1-related protein | Bos | MSYKPIAPAPSSTPGSSTPGPGTPVPTAGSVPSPSGSVPGAAGPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART | Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activati... | Q58CN7 |
Q81C68 | SSUB_BACCR | Aliphatic sulfonates import ATP-binding protein SsuB | Bacillus cereus group | MTVSIDGVSKYFLKQTGTVQVLENINFQLEEGDFVTVIGPSGCGKSTLLKIVAGLDNDFEGEVVIDGEPILKTSKKQGFIFQEHRLFPWLTVEENIAADLSLKDKYVKDKVREWVEIVRLDGFEKSYPKEISGGMSQRVAIARALLRDPNVLLLDEPFGALDAFTRSHLQEVLLNIWEQKKTTMIFVTHDIDEAIYLSNRIIIMSAKPGKIHKVIENNLPYPRNKTSQSFQQLRTKVLQQFEYGGLIQTSI | Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system. | Q81C68 |
B0BX35 | SYE1_RICRO | Glutamyl-tRNA synthetase 1 | spotted fever group | MTKVITRFAPSPTGMLHVGNIRAALLNWLYAKKHNGQFILRFDDTDLERSKQEYKDAIEEDLKFLNINWDQTFNQLSRLSRYDAIKNLLLDKKRLYACYETPEELELKRKFQLSKGLPPIYDRASLNLTEEQAKKYIEQGRKPHYRFLVNHEPISWHDMIKGEVKYDGKALSDPIVIRADGSMTYMLCSVIDDIDYDITHIIRGEDHVSNTAIQMQMFEALNTTPPTFGHLSLIINKDEKISKRVGGFEIATLRKEIGIEAMAIASFFSLLGSSAQILPYKSMEKLANQFEISSFSKSPTIYQPEDLERLNHKLLISLDF... | Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | B0BX35 |
B1I461 | PLSY_DESAP | Lysophosphatidic acid synthase | Candidatus Desulforudis | MSALAVILVIGLSYLVGSVPTGYLIARHVKGIDIRGHGSGNIGATNVWRTLGPGWGLASLVGDTAKGIVAVLLGRAVGVPGLELLTGAAALTGHGWSVFLRFQGGKIIATSLGVLIMLPPVALATAAAVWIAVLALTRYVSLASIIAASSVPLAFALGGVGWRHVLFGLFLALVAVYKHRANIDRLLKGKESRFSFRK | Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | B1I461 |
P60850 | ALBA_METMP | DNA/RNA-binding protein Alba | Methanococcus | MDNIVYVGNKGVMNYVLAVITQFNSENAQEVIVKARGKAISRAVDVEEMVTKRFMPEVKIKEINLGTDHIQGEDGKSINVSTIEIILFK | Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stabili... | P60850 |
Q9CP05 | PEPT_PASMU | Tripeptide aminopeptidase | Pasteurella | MLNQQQTYKLLERFLHYTTYDTQSKSGAKISPSSAGQLKLAKHLQQELFALGLQDIDISKHSVVTAFLPSNVNPHSPTIGFIAHLDTATQCSGKNVQAEVIENYRGGDIALGVGEEFISPAHYQFLHQLIGKTLVVADGNTLLGADNKAGIAEIMTALAVLKEENLPHCNIRVAFTPDEEIGLGMQFFPVEKFPCDWAYTIDGGEVGELEYENFNAATAIVTIEGVNMHTGSAKDKMINALTLACEFQQGFPAEETPEQTEGKQGFYHLSHFTGHVEKVELQYLIRDFDRDGFEQRKIFIQQLVDRFNQQKRLKKPITLE... | Cleaves the N-terminal amino acid of tripeptides. | Q9CP05 |
Q73YQ3 | MURE_MYCPA | UDP-N-acetylmuramyl-tripeptide synthetase | Mycobacterium avium complex (MAC) | MVSVPTGLRPSAVPGVRLPALADQVGAVMAGPDRRAAVPDVTVTGVTLRAQDVLPGDLFAALPGATTHGARHAAEAIERGAVAVLTDAAGVAQLTGGRTTPTLLHPRPRSVLGQLAAAVYAHPSERLTVIGITGTSGKTTTTYLVESGLRAAGRTAGLIGTVGIRIDGADIPSALTTPEAPALQALLAAMAEQRVDTVVMEVSSHALALGRVDGTRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPNSPLRAHRAVVCIDDEAGREMAARAGDAVTVSAEGQPAHWRAVEVAPLGTGGQQFTVIDPAGVQHRAGIRL... | Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. | Q73YQ3 |
B3QL20 | RSGA_CHLP8 | Small ribosomal subunit biogenesis GTPase RsgA | Chlorobaculum | MNETLSGVVTRVTGATYIVETGDGPKVRCRTVPSTVSENEGSNLVAVGDRVEFRPKASETEMAEGVIVRVEERRSVLERRREVRRNRSKEKEQVIAANIDQIVLITSFDDPPFNSRLVDRYLVFAESEHLPLLIVVNKIDLDEEGMVEEDLEVYRNLDCNICLVSAEDGRGIEELRELLRDRLSAFSGHSGVGKSTLINLLVGREELRTAETSGKTGKGVHTTTSSAMFQLPGGGYVIDTPGIREFNLAGITRENLRFYYTEFLRFMPECAFSSCSHTVEPGCAVIAAVESGRIDAERYESYLALLDSLDE | One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimula... | B3QL20 |
A8X3A7 | PAT2_CAEBR | Paralyzed arrest at two-fold protein 2 | Caenorhabditis | MREGSFPRRTRLLCLLAAVVLISTVTSFNIDTKNVVLHHMANNYFGYSLDFYNEQKGMPVLVVGAPEAETTNPNLSGIRRPGAVYACSVNRPTCREVHVDKMKGNLKKLNGSHLVPIEDKAYQFFGATVKSNDKHDKLLMCAPKYKYFYSKFEVIEPVGTCFYAENGFEKTEEFSSCKQEPARHGRHRLGYGQCGFSGAIPGKKNQDRVFLGAPGVWYWQGAIFSQNTKNQTDRPNTEYGSKEYDHDMMGYATATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGALAVADVNKDGRD... | Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell mi... | A8X3A7 |
A6VIV7 | ILVD_METM7 | Dihydroxy-acid dehydratase | Methanococcus | MISDNVKKGVIRSPNRALLKACGYSDEDMEKPFIGVVNSFTEVVPGHIHLKTLSEAVKHGVYANGGTPFEFNTIGICDGIAMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKCELISLFEGVGEYQVGKITEEELKSIEECACPGAGSCAGLYTANSMACLTEALGLSLPMCATIHAVDAQKVRIAKKTGSKIVDLVKEDVKPTDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSNEVPHIASIKPGGEHYMIDLHNAGG... | Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (... | A6VIV7 |
A6MMB4 | RPOB_CHLSC | Plastid-encoded RNA polymerase subunit beta | Chloranthus | MLRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELHKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVPAGLIWKTSRDMQEQTVFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWGGRSELEIDRKARIWARVSRKQKISILVPSSAMGSNLREILDNVCYPEIFLSFPNDKEKKKFGSKENAILEFYQQFACVGGDPIFSESLCKELQKKFFQQRCELGRIGRRNMNRRLNLDIPQNNIFLLPRDVLAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADL... | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | A6MMB4 |
P0CB78 | PYRE_STRPN | Orotate phosphoribosyltransferase | Streptococcus | MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVEAIKEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKADKNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | P0CB78 |
Q5F8D4 | LEU1_NEIG1 | Alpha-isopropylmalate synthase | Neisseria | MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAES... | Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). | Q5F8D4 |
B1J508 | KDSB_PSEPW | CMP-2-keto-3-deoxyoctulosonic acid synthase | Pseudomonas | MSLDFTVVIPARLRSTRLPGKPLLLIAGKPMVQHVWEQARKSGAGRVVIATDDASIVEACQAFGAEVLMTRADHESGTDRLAEVAAQLGLPADAIVVNVQGDEPLIPPVIIDQVAANLAAHPEAGIATLAEPIHDPETVFNPNAVKVVSDKNGLALSFSRAPLPWARDAFAKDRNQLPQGVPYRRHIGMYAYRVGFLQDFVSWGPCWLEQTEALEQLRALWHGVRIHVADAIEAPAVGVDTAQDLERVRRLLEA | Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | B1J508 |
A2T352 | PETG_ANGEV | Cytochrome b6-f complex subunit V | Angiopteris | MVEALLSGIVLGLIPITLAGLFVTAYLQYRRGDQLDL | Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex. | A2T352 |
P81045 | COX17_PIG | Dopuin | Sus | PGLAAAIPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI | Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | P81045 |
Q492U0 | RNT_BLOPB | Exoribonuclease T | Candidatus Blochmannia | MICKDDHSTLRARFRGFYPVVVDVETAGLDANINALLEIAVATFKMDEYGWLCVDGSLNFHIKSFPGAIIQPESLAFNGIDLNSPLRAAVTEQEALHEIFEMVRQGIKTQGCSRAIIVAHNAFFDHSFLMAAVERVSFMEKNPFHPFVMFDTATLSGLVFGQTVLAKACACAGVFFDKNKAHSALYDTERTAMLFCELVNKWKRLGGWPLTPCCIES | Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. | Q492U0 |
Q8Z8H8 | COBD_SALTI | L-threonine-O-3-phosphate decarboxylase | Salmonella | MALFNSAHGGNIREAATVLGISPDQLLDFSANINPLGMPVSVKRALIDNLDCIERYPDADYFHLHQALARHHQVPASWILAGNGETESIFTVASGLKPRRAIIVTPGFAEYGRALAQIGCEIRRWSLREADGWQLTDAILEALTPDLDCLFLCTPNNPTGLLPERQLLQAIADRCKSLNINLILDEAFIDFIPHETGFIPALKDNPHIWVLRSLTKFYAIPGLRLGYLVNSDDAAVARMRRQQMPWSVNALAALAGEVALQDSAWQQATWHWLREEGARFYQALCQLPLLTVYPGRANYLLLRCEREDIDLQRRLLTQRI... | Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. | Q8Z8H8 |
B1YB90 | PDXT_PYRNV | Pyridoxal 5'-phosphate synthase glutaminase subunit | Pyrobaculum | MKAGVLALQGDVEEHIQAFRKAAQELGRSVEVVQVKRPQDLREIAVLAIPGGESTTIGALARRTGLLDALRDAIKGGLPTLGTCAGAIFLAKEVRDSVVGETKQPILGLMDIAVVRNAFGRQRESFEVDLREEGIGALKAVFIRAPAFTKAWGSARLAAPLKHPELGQIYAAAFQGHMVATAFHPELSTTAVHRYMLNLAKT | Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | B1YB90 |
A8FD81 | CODY_BACP2 | GTP-sensing transcriptional pleiotropic repressor CodY | Bacillus | MALLQKTRIINSMLQDAAGKPVNFKEMAETLRDVIDSNIFVLSRRGKLLGYSINQQIENPRMKKMLEDRQFPEEYTKSLFNIPETSSNLDINSEYTAFPIENRDLFESGLTTIVPIIGGGDRLGTLILSRLQDTFKDDDLILAEYGATVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH | DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer b... | A8FD81 |
Q9Z768 | MNME_CHLPN | tRNA modification GTPase MnmE | Chlamydia | MLKHDTIAAIATPPGEGSIAVVRLSGPQAIVIADRIFSGSVASFASHTIHLGQVIFEETLIDQALLLLMRSPRSFTGEDVVEFQCHGGFFACSQILDALIALGARPALPGEFSQRAFLNGKIDLVQAEAIQNLIVAENIDAFRIAQTHFQGNFSKKIQEIHTLIIEALAFLEVLADFPEEEQPDLLVPQEKIQNALHIVEDFISSFDEGQRLAQGTSLILAGKPNVGKSSLLNALLQKNRAIVTHIPGTTRDILEEQWLLQGKRIRLLDTAGQRTTDNDIEKEGIERALSAMEEADGILWVIDATQPLEDLPKILFTKPS... | Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. | Q9Z768 |
Q8DSK2 | RECX_STRMU | Regulatory protein RecX | Streptococcus | MKITKIEKKKRLYLIEIDEAEHFYITEDTIVHFMLSKNKEILPEQLEEIKTFAQFSYGKNLALYYLSFKQRTEKEVKDYLIRHDINTTVISQILTQLKEEKWLDDSKYIDNILQQNLHSGDKGAFVLKQKLLQKGIESQLIEDMLKDFDFSSICIKTAQKLLKKYQSKLPKRALKDKLKQALTTKGFSYQEAQIALEDLDIENNSENEEELIYKELDKQYRKYSKKYENYELRQRLTQSLARKGFAFDAIKNALREYL | Modulates RecA activity. | Q8DSK2 |
P28715 | ERCC5_HUMAN | Xeroderma pigmentosum group G-complementing protein | Homo | MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIKTAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKKNYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTVAEVDSESLPSSSKMHGMSFD... | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair . Makes the 3'incision in DNA nucleotide excision repair (NER) . Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble . Plays a role in base excision repa... | P28715 |
Q05934 | VID22_YEAST | Vacuolar import and degradation protein 22 | Saccharomyces | MRAMDTQVQSAERGLVLPPMNSTVSSATAATTATNTDTDTDGDRDEERESLAEDGSEWVPAYMLTRDRSRYLGHFLGVDKMLEAVKCKYCGVIIRRQGNSISMAEASQTHLWSTHKIDPNANYYSGWTGVEAGSTFMVRPPLKNHQGGSATTNSIANLLEIDEDFLKRTREKEMALPLVQSLAIIIASENLPLSFVDNTAVRLLINQNANSLSFIDHDLILNAIRSIAYNLDRIIQRTALRNNSDLSLIIDKNYLLMDPTDRSNQLSNRLKNQLFEMQKINFFSLSHSVWNNTISILSIQYYDDFHSQVKTLPLIIQNLH... | Has a role in the negative regulation of gluconeogenesis. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. This is an indirect role and requires cyclophilin A. | Q05934 |
P0CJ75 | HMN8_HUMAN | MT-RNR2-like protein 8 | Homo | MAPRGFSCLLLSTSEIDLPVKRRA | Plays a role as a neuroprotective and antiapoptotic factor. | P0CJ75 |
D7BMJ2 | GLGE_ARCHD | (1->4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase | Arcanobacterium | MSTLQHKTSSARRSSRRSVAAPDFVAVSRIPIVEVSPQLLDGTAPVKSTVDESFPVQATIFREGHDKFAARAVLVDGAGHTVDSVPMCDVSPGLFRFEGWLTPRVPGPHRFFVEAWSDPYATWLHNAEIKVPAGIDVGLVFAEAEVLFKAALKGTPVRSGERAAIRDALTVISKRRALPEVKLAAARSEEVRAAFAAYPVKELVSRSREYPVFVDRVRALVGSWYELFPRSVGATRDSESGEWTSGTLRTAATDLDRVAGMGFDVVYIPPVHPIGLTNRKGRNNSLTAVPGDPGSPYAIGSDAAGGHDAIEPSLGTFEDF... | Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. | D7BMJ2 |
Q2S5G4 | CYSH_SALRD | Thioredoxin-dependent 5'-adenylylsulfate reductase | Salinibacter | MAFASDESASPWSSTRLAALNAQFEPHGPKAILNWATHTFGDDLAQGTGFGPSGIVIMHMLADLRPGTTVFYLDTDLLFPETYELCDDLDERLDVDVTRVHGGLSLDEQAEQEGEELWNRNPNRCCFLRKVKPLRNFLDDRRAWITGVRRDQSERRADTDILSWEGQYGVFKINPLANWTQKEVWKYLFEHDLPYNPKHDQGYPSLGCVPCTEPVDQADGYSREGRWSDRDKTECGLHTSPEDEDGAHAAES | Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor. | Q2S5G4 |
B0C7T1 | CHLN_ACAM1 | Light-independent protochlorophyllide reductase subunit N | Acaryochloris | MTLADAQPQALDFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDISAKLNDYEELKRLCMQIKRDRNPSVIVWIGTCTTEIIKMDLEGLAPRLESEIDIPIVVARANGLDYAFTQGEDTVLAAMAHRCPKGSAVVEESEKQERGNAITSLLNFGKKKEEVVAEESEYHDHAPLVMFGSLPDPVVTQLTLELKKQGIKVNGWLPAKRFTELPVIDEGYYVAGVNPFLSRTATTLMRRRKCKLIGAPFPIGPDGTRAWIEKICSVLDVEPKGLEEREAKIWANLEDYLEI... | Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. | B0C7T1 |
A7NBV5 | RUVA_FRATF | Holliday junction ATP-dependent DNA helicase RuvA | Francisella | MISFIKGVLIEKDPTALLIDVNGIGYEVFVPMTTFYTLGDIDSQVSLYTHFVVREDAQQLYGFKSKVDKKVFQELIKVNGIGARTAIAILSGMDSKTLLHCIENKDYALLATVPGIGKKTAERLVVEIYDKLLKMANEIYAQTSGTTTTSQDSQAQQAPTSVVLANSIFNESVDALLALGYKQKDAEKMARSAMGDATTAAEVIRKALQGSIKSKG | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA... | A7NBV5 |
A0QX66 | BIOD_MYCS2 | Dethiobiotin synthase | Mycolicibacterium | MTVLAVTGTDTGVGKTVTTAALACAARLARRDVAVCKPVQTGTIDGDDDLGEVRRLSGVTALHGGWRYPEPLAPVAAAGRAGAPLPTRTELVGSVRAVDAAGRLTIVEGAGGLLVALGADGVTLRDLAHDLGAQVLIVVSPGLGTLNHTALTLEALAAHGLSCAGLVIGAWPAEPGVAELDNRTALEALAPVRAVLPAGAGAASPERFEALSAAAFDADWITSLS | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. | A0QX66 |
Q9JU49 | PAND_NEIMA | Aspartate 1-decarboxylase alpha chain | Neisseria | MFRTMLGGKIHRATVTEADLNYVGSITVDQDLLDAAGIYPNEKVAIVNNNNGERFETYTIAGKRGSGVICLNGAAARLVQKSDIVIIMSYVQLSEPEIAAHEPKVVLVDGNNKIRDIISYEPPHTVL | Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | Q9JU49 |
Q9BJK5 | NHR97_CAEEL | Nuclear hormone receptor family member nhr-97 | Caenorhabditis | MSGDAQPSSNQRATEARPPPSPPLVNEKAAIGALCVVCGDRACSHLYYGVAACHGCKCFFWRTVKSRLNYVCRYGGNCSISTAGRNACRYCRFHRCLFVGMKIEAVKMDRKLTKRKKEKTDEDDTDDGGSHESFETTTDAKRAKFDNSLLISSLQLIDKTSSAGNAKLSTLHFVQPSLQNLLDEPELLDGFRSEMSYRATRQADEQLCYDSERRLVTWAIDWCRQTAEIADVHHTNDKISLLRASCAPLVLLELGCQSSFGPSDTQIPFCNNSFLSAHCIPPSTSFLRWKTIQSLNKWAQRELKPLCLRAKEIVLLKALI... | Orphan nuclear receptor. | Q9BJK5 |
C3P9F1 | HEM1_BACAA | Glutamyl-tRNA reductase | Bacillus cereus group | MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCALLEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEK... | Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | C3P9F1 |
C1F647 | RS12_ACIC5 | 30S ribosomal protein S12 | Acidobacterium | MPTFSQLVRKGRTAPRYKTASPALQGSPQRRGVCTRVYTQTPKKPNSALRKVARVRLTNGIEVTTYIPGIGHNLQEHSIVLIRGGRVKDLPGVRYHVVRGTLDSVGVANRKQGRSKYGAKRAKGGAAAGKK | Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The com... | C1F647 |
A5U9E9 | PAPA2_MYCTA | Polyketide synthase-associated protein A2 | Mycobacterium tuberculosis complex | MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQQAQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDTYHSWFEFDNAEHIVRHTIADPADIEVVQAEHQNMTSAELRHHIATPQPLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIVGVLFIEIHMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANNDGTLPHFPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAALAERELTNCETFDVVTTTDTRRTPTELRTT... | Catalyzes the acylation of trehalose-2-sulfate by adding the palmitoyl group at the 2'-position to yield the intermediate trehalose-2-sulfate-2'-palmitate (SL659). | A5U9E9 |
Q5B7T4 | MICA_EMENI | Nonribosomal peptide synthase micA | Aspergillus subgen. Nidulantes | MVGSVVEAHRQSVGCLRNLSQLLAWASNTSGGLIFYSREDDVLTSTRISYAELLADAGEKARLIGQITGLSSESIILLHFDTQREVIEWFWAATLAGYLPAISTPFVDDTARRKAHLLHLHAQLNQPVVLTSKRLVPEFLGLEELRLHDVESLLSSAAKDGLIQYLGVQKLAEDVAVLMLTSGSTGSAKAVPLRHGQLLTAIQGKSTHHGTLPGDVFYNWVGLDHVASLTEIHLHALILGSDQVHTAASELLRNSLQFVRLLDTHKVAYTFAPNFFLTKVLDSLRENPTFTADLSSLKALISGGESNVVVTCDKLTRELR... | Microperfuranone synthase is the only protein required for the biosynthesis of the secondary metabolite microperfuranone from phenylpyruvic acid (PPA) . Several steps for the microperfuranione biosynthesis have been proposed . These steps include the activation of PPA, by the micA adenylation (A) domain to AMP-phenylpy... | Q5B7T4 |
C3PP97 | RL14_RICAE | 50S ribosomal protein L14 | spotted fever group | MIQMQSILEVADNSGAKKVMCIKVLGGSHHMVAKLGDVIVVSVKDAIPGGKVKKGDVYKGVIVRTKTGVVRPDGSTIKFDQNALVLLNKQDEPIGTRVFGPVTRELRAKKYVRIMSLAEEVL | Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome. | C3PP97 |
Q1GXD5 | RBFA_METFK | Ribosome-binding factor A | Methylobacillus | MVKEFSRSDRVAEQIQRELADLLQFEVKDPRVSSMVTVTEVEVSGDMSHAKVYYTAPQGTPELQKGLEKTAGFLRSQLARRLLLRTVPQLHFVYDASIDRGMRIAKLIDEALPPVADPDQDSEPN | One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal heli... | Q1GXD5 |
P0A434 | OPD_BREDI | Phosphotriesterase | Brevundimonas | MQTRRVVLKSAAAAGTLLGGLAGCASVAGSIGTGDRINTVRGPITISEAGFTLTHEHICGSSAGFLRAWPEFFGSRKALAEKAVRGLRRARAAGVRTIVDVSTFDIGRDVSLLAEVSRAADVHIVAATGLWFDPPLSMRLRSVEELTQFFLREIQYGIEDTGIRAGIIKVATTGKATPFQELVLKAAARASLATGVPVTTHTAASQRDGEQQAAIFESEGLSPSRVCIGHSDDTDDLSYLTALAARGYLIGLDHIPHSAIGLEDNASASALLGIRSWQTRALLIKALIDQGYMKQILVSNDWLFGFSSYVTNIMDVMDRV... | Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diest... | P0A434 |
B3PC22 | QUEC_CELJU | Queuosine biosynthesis protein QueC | Cellvibrio | MSRKKAVILVSGGLDSTTVIAIARSQGYDCYTISFDYGQRHRAELKAAEITAKAHGSLEHKVIRLDLGAIGGSALTDTSIDVPEEETSGIPVTYVPARNTVFLSIALGWAEVLGALDIFIGVNAVDYSGYPDCRPDYIAAYETMANLATKRGIEGERLHIRTPLINLTKAQIIQQGLALGVDYRLTVSCYQANDGGEACGKCDSCRLRKQGFEQAGVADPTRYAF | Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | B3PC22 |
B4U4Y3 | TIG_STREM | PPIase | Streptococcus | MSTSFENKATNRGVITFTISQDKIKPALDQAFNKIKKDLNAPGFRKGHMPRPVFNQRFGEEVLYEEALNIVLPAAYEGAVAELELDVVAQPKIDVVSMEKGQEWTLTAEVVTKPEVKLGDYKDLTVEVEASKEVTDEEVDAKVERERNNLAELVVKEEAAVEGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEEQLVGAKAGDTVEVNVTFPENYQAEDLAGKAAKFVTTVHEVKAKEVPELDDELAKDIDEEVETLDELKAKYRKELEASKEAAYDDALEGAAIELAVENAEIVELPEEMVHDEVHRSVNE... | Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. | B4U4Y3 |
Q9H7S9 | ZN703_HUMAN | Zinc finger elbow-related proline domain protein 1 | Homo | MSDSPAGSNPRTPESSGSGSGGGGKRPAVPAAVSLLPPADPLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIGKPDPPPSSKLNSVAAAANGLGAEKDPGRSAPGAASAAAALKQLGDSPAEDKSSFKPYSKGSGGGDSRKDSGSSSVSSTSSSSSSSPGDKAGFRVPSAACPPFPPHGAPVSASSSSSSPGGSRGGSPHHSDCKNGGGVGGGELDKKDQEPKPSPEPAAVSRGGGGEPGAHGGAESGASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYHGSIV... | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. | Q9H7S9 |
P22014 | TBB2_COLGR | Beta-2-tubulin | Colletotrichum graminicola species complex | MREIVHLQTGQCGNQIGAAFWQNISGEHGLDSNGVYNGTSELQLERMSVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGK... | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-... | P22014 |
Q87TR9 | RNPA_PSESM | Protein C5 | Pseudomonas | MSRDFSREKRLLTPRHFKAVFDSPTGKVPGKNLLLLARNNDLDHPRLGLVIGKKSVKLSVERNRLKRLMRESFRQHQDSLVGWDIVIVARKGLGDVENPELIQHFGKLWKRLARSRPTPEEKSEPAGVDSTDA | RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the riboz... | Q87TR9 |
B0S1E4 | RBFA_FINM2 | Ribosome-binding factor A | Finegoldia | MNIKRVRRISSEIKKVISSSIINSLKDPRIDKLNVSVTEVKVTNDLSFATVYIAVIGDDEKKKQTLEGLNKAKGFLKKQIGENVDLRHVPQLIFKIDETSEQSMHIENLIKSIHEENHNEN | One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal heli... | B0S1E4 |
P71007 | ALBE_BACSU | Antilisterial bacteriocin subtilosin biosynthesis protein AlbE | Bacillus | MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLKEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKAIHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFETETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELE... | Involved in the production of the bacteriocin subtilosin. | P71007 |
B5XQH2 | SUFS_KLEP3 | Selenocysteine reductase | Klebsiella | MTFSVERVRADFPVLNREVNGQPLAYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHTLSAEATARMEAVRQQAANFLNAGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISEMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGLFDPRTRLLAITEVSNVLGTENPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSGHKLYGPTGIGVLYGRSELLQAMAPWEGGGSMIATVSLTEGTTWNRAPWRFEAGTPNTGGIIGLGAALTYVSQLGLTQIAEYEQTLMRYALEALRAV... | Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts ... | B5XQH2 |
Q1BYX9 | HEMH_BURCA | Protoheme ferro-lyase | Burkholderia cepacia complex | MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATAFDAAFDALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMAALGLSTTECHVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKTFHRIP... | Catalyzes the ferrous insertion into protoporphyrin IX. | Q1BYX9 |
Q5HFM3 | GCSPA_STAAC | Glycine dehydrogenase (aminomethyl-transferring) subunit 1 | Staphylococcus | MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHI... | The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Q5HFM3 |
Q2S3R4 | RL3_SALRD | 50S ribosomal protein L3 | Salinibacter | MSSGLIGKKVGMTSVFDDEGNNVACTVVEAGPNVVTQVKSEGRDGYSAVQLGFDNVKEKNVTQAMLGHFEKAGCPPKRMLSEFRDFGDDVDLGDVVRVQDLFQEDERIDVVGVSKGKGFQGVVKRHGFSGVGMMTHGQSDRQRHPGSIGASADPSRVFKGVRMAGQTGGERTKIQNLRVVRILADQNAILIHGSVPGPKSEYVELHKK | One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | Q2S3R4 |
Q48RM8 | ALR_STRPM | Alanine racemase | Streptococcus | MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELELAVANAITVTIASLDWIALARLEKKECQGLKVHVKVDSGMGRIGLRSSKAVNLLIDSLKELGADVEGIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSDLSLPFPLQEALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLPKA... | Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | Q48RM8 |
Q493W6 | EFP_BLOPB | Elongation factor P | Candidatus Blochmannia | MVLYNINEFRTGLKIIQNREPCVIISHESIKPGKGQAFSRVRFRQIISGKILEKTFKSGDFLESANIMEIRLVYVYHDNEFWYFMDEKNFEEIAVAAKIIGTNIKWITTQLHYIVTLWNKVPILVTPPDSIELKIIKITPIKKNSTGSSGIKLATVSTGAIVKVPFFIQLGELIKINTRSGIYISRAK | Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation. | Q493W6 |
Q9FJD1 | OPT8_ARATH | Oligopeptide transporter 8 | Arabidopsis | MKDFTDTISESECDDEISIVPQVELTVPKTDDPTSPTVTFRMWVLGITACVLLSFLNQFFWYRTNPLTISSVSAQIAVVPIGHLMAKVLPTRRFFEGTRWSFTMNPGPFSTKEHVLITVFANSGSGAVYATHILSAVKLYYKRRLDFLPALLVMITTQVLGFGWAGLYRKHLVEPGEMWWPSNLVQVSLFRALHEKENKSKWGISRNQFFVITLITSFSYYLLPGYLFTVLTTVSWLCWISPKSILVNQLGSGSAGLGIGSFGLDWSTIASYLGSPLASPFFASANIAAGFFLVMYVITPLCYYLDLYNAKTFPIYSGKL... | May be involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. | Q9FJD1 |
A5FHA4 | PYRG_FLAJ1 | UTP--ammonia ligase | Flavobacterium | MNQTKYIFVTGGVTSSLGKGIIAASLAKLLQGRGYRTTIQKFDPYINVDPGTLNPYEHGECYVTDDGAETDLDLGHYERFLNVPTSQANNVTTGRVYLSVIEKERRGEFLGKTVQVVPHITNEIKDRMQLLGKSGDYDIVITEIGGTVGDIESLPYIESVRQLVWELGENNGIVIHLTLVPYLAAAGELKTKPTQHSVKTLMESGIKADILVCRTEHELSQELRQKLALFCNVKKEAVIQSIDASTIYEVPNLMLEEGLDVVALKKLDLPKKASPDLKNWNTFLKRLKSPKQTVNIGLVGKYVEMQDCYKSILEAFIHAG... | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | A5FHA4 |
A8SEF7 | NU4LC_CERDE | NADH-plastoquinone oxidoreductase subunit 4L | Ceratophyllum | MMLEHELVLSAYLFSIGIYGLITSRNMVRALMCLELILNAVNMNLVTFSDLFDSRQLKGDIFSIFVIAIAAAEAAIGPAIVSSIYRNRRSTRINQSNLLNK | NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translo... | A8SEF7 |
D4A7C0 | GPN2_RAT | ATP-binding domain 1 family member B | Rattus | MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLEPLRGHYFLFDCPGQVELCTHHTSLRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHVNLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFSHYRQLNEKLVQLIEDYSLVSFIPLNIQDKDSIQRVLQAVDKANGYCFGVQEQRSLEALMSAAVGADFHFSSTLGIQEKYLASSDQTAEQEAMQL | Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. | D4A7C0 |
P53469 | ACT2_OXYTR | Actin, micronuclear | Sterkiella | MSDQQTCVIDNGSGVVKAGFAGEDAPRAVFPSIVGRPKNVSALIGVDSASEYLGDEAQQKRGVLKIFYPIEHGIVKDWDDMEKIWNHTFYVELRVQPDEHPILLTEAPLNPKTNREKMTQIMFETFNVPALYVVIQAVLSLYSAGSTTGIVCDAGDGVTHTVPIYEGFSIPHAVSRIQLAGRDLTTFMAKLLTERGYNFTSSAELEIVRDIKEKLCFVALEYESALKQSHDSSQFEKNYELPDGKVITIGSERFRCPEYLFKPLEMNGRELDSIQDLTYKSIQECDVDVRRDLYQNIIISGGTTMNEGIGERLLKEIENR... | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | P53469 |
Q9P567 | SUCB_NEUCR | Succinyl-CoA synthetase beta chain | Neurospora | MFKLGRNRALASAFAATSRAPLASRLPSVSQQQRRALSIHEYLSADLLRQYGIGVPKGDVARTGAEAEAIAKQIGGEDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPTEAKMFAEQMIGHKLITKQTGAQGRLCSAVYICERKFARREFYLAVLMDRASQGPVIVSSSQGGMDIEGVAKENPEAIHTTYIDINVGVTDEMARDIATKLGFSEQCVEEAKDTIQKLYKIFCEKDATQIEINPLSETSDHKVMAMDAKFGFDDNADFRQPDIFKLRDTTQEDPDEVRAAQAGLNFIKLDGDIGCLVNGAGLAMATMDIIK... | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the b... | Q9P567 |
Q220R4 | RUVA_ALBFT | Holliday junction ATP-dependent DNA helicase RuvA | Rhodoferax | MIGKLSGTLDDKNPPQVIVDCHGVGYEVLVPMSTFYNLPELGARVSLLTHFVVREDAQILYGFATSQERAAFRELIKISGVGPRTALSVLSGMSVAELAQAVTLQEGGRLIKVPGIGKKTAERLLLELKGKLGPDIGVAASVANDSQADILQALLALGYSDKEAAAALKALPSDVGVSEGIRLALRALGK | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA... | Q220R4 |
Q5NGP7 | KDSD_FRATT | Arabinose 5-phosphate isomerase KdsD | Francisella | MEISMTSHINNAVETFRLEIETLEKLKNSIDENFEKACEIILENNRDKSRVIITGMGKSGHIGKKMAATFASTGTPAFFVHPGEAGHGDFGMITKNDVLIAISNSGTSSEIMGLLPMIKHLDIPIIAITSNPKSILARNSNVTLNLHVDKEACPLNLAPTSSTTATLVLGDALAIALLKAKNFSEKDFAFSHPNGALGRKLILKVENIMRKGNEIPIVKPTDNIRKAILEISDKGVGNTLVAENNTLLGIFTDGDLRRMFEAESFNSQRAISEVMTKNPKSISKEEMAITALEKMEKYEITSLAVVDNGHNILGIVTMHD... | Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). | Q5NGP7 |
B7VPD0 | BTUD_VIBA3 | Vitamin B12-transporting ATPase | Vibrio | MIQIKSLSVGARLLPLSFELKQGQVTHVIGPNGSGKSTLLEAISGVGDGYKGDIKLDGQDLSELSLQDLSLHRAYLCQSARPAFNLEVFQYLALSLPSSSHGLDIEINAALDEISQMLDISDKLHRSIQTLSGGEWQRVRLAGMCLQIWPTLNPYAKLLILDEPAAPLDIAQEALLYKLIERVAEKGIAVIMANHDLNRTLRHADQVLLLEKGVLQTSGSAEQVLVPEQLESVFNTQVKSISVDNQTYLLFG | Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. | B7VPD0 |
P36383 | CXG1_HUMAN | Gap junction alpha-7 protein | Homo | MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQ... | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | P36383 |
B6YVS9 | TOP6B_THEON | Type II DNA topoisomerase VI subunit B | Thermococcus | MAEASQLFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKVIVEDNGPGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDIIEAWVKIDVDKNEGKIVKKERHPNPKGWRGTRIELEVKNVRYVRSKQGVYWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPKGVLTDDVYRMAKKTRRNTVRRFLIGEFSRISDKKVDELIKYIAALRLIKTEKDKAVQDQLYERLMNGEVDKVLRSFKGYTKVVK... | Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | B6YVS9 |
Q6F9D2 | UVRB_ACIAD | Excinuclease ABC subunit B | Acinetobacter | MRVNDNQPFDLVTNYQPAGDQPQAIKKLVSGIEQGNRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPEAYMKMLLHVVEGDRINRDDLIRRLVEMQYTRNELEFLRGTYRIRGEILDVFPAESDQFAIRIELFDDEVDSIRWFDPLTGKMQRKVPRVTIYPKSHYVTPKDNLSRAIETIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGR... | The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP bindi... | Q6F9D2 |
Q2RM40 | MCSB_MOOTA | Protein-arginine kinase | Moorella | MSLNLERNSKWMEGSGPQADIVISSRIRLARNLKGLPFPNLMNSDQQARVVSQVSRAIQAPMVFQAVGELKLQPLRELAPVERQILVEKHLISPDLAAGGGEKAVVLRDDEAVSIMVNEEDHLRLQCLLPAMMLHEAWRLADAADDALENELDFAFDQERGYLTACPTNVGTGLRASTMLHLPALVLTRQAGPVLSALTKVGVAVRGLYGEGTEAQGNIFQVSNQITLGRSEEEIINNLSAVTVRLADQEREARELLRRQSRWQLEDRVGRAYGVLTNARILSSQEALQLLSDVRLGAEMKIIRGLDQRLLNQLMVRIQP... | Catalyzes the specific phosphorylation of arginine residues in proteins. | Q2RM40 |
B0C6F8 | TRPA_ACAM1 | Tryptophan synthase alpha chain | Acaryochloris | MTSVSDCFAQLRDRGQCALIPFLTAGDPDLATTASALRQLDASGADLIELGVPYSDPLADGPVIQAAATRALQRGTRLDQVLEMVTELSPEIRAPIILFTYYNPIYHRGVAEFLQQIAKAGVRGLVVPDLPLEESENLLQQAADLGIEVTLLVAPTSSKERIEKIALRSQGFIYLVSTTGVTGMRTKVENRVQDLIADLRQVTDKPIGVGFGISRTEHARQVMDWGADAAIVGSAFVNRLSEGSPSQGLSAISTFCRSLKSSLLLDA | The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. | B0C6F8 |
P47583 | RPOB_MYCGE | Transcriptase subunit beta | Mycoplasma | MSQKSNFFQKRYSPTATRRYYGKIETNFIQPNLADIQIKSYQKFLDHDLEKLIASYFPIKSPNDRYTINFRGLHRTEPERDEAQSRAQSKTYEVGIYADLELVDNDKGTVKKARKSKKNIASNTNGVFLASMPLITHDGVFIINGIEKFVISQITRSPGIYMLTKSQLKLSNSRKRVQEGYVCEVLPANGSVMLIYISNKKKIEDAFVQILLRDAVREGAKIFPITTLLKAFGLNNREILKIFKNNEFIKRSLEAEIYNAKDFLSNVDPEIKNLLKEFRDGKTDLRRKGIASDQKLRSLVNEYVTLEKQYNALKQTSPND... | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | P47583 |
Q5M750 | VQ4_ARATH | MPK3/6-targeted VQ-motif-containing protein 1 | Arabidopsis | MENSPRYREATNLIPSPRCHNSNNSCGMSSSSESNKPPTTPTRHVTTRSESGNPYPTTFVQADTSSFKQVVQMLTGSAERPKHGSSLKPNPTHHQPDPRSTPSSFSIPPIKAVPNKKQSSSSASGFRLYERRNSMKNLKINPLNPVFNPVNSAFSPRKPEILSPSILDFPSLVLSPVTPLIPDPFDRSGSSNQSPNELAAEEKAMKERGFYLHPSPATTPMDPEPRLLPLFPVTSPRVSGSSSASTS | Acts as negative regulator of WRKY33 transcription factor activity in the promotion of defense gene expression. Acts as a negative regulator of pathogen-associated molecular pattern (PAMP)-induced responses to modulate resistance to pathogens. | Q5M750 |
Q6NQH4 | TAF13_ARATH | TBP-associated factor 13 | Arabidopsis | MSNTPAAAASSSSKSKAAGTSQPQEKRKTLFQKELQHMMYGFGDEQNPLPESVALVEDIVVEYVTDLTHKAQEIGSKRGRLLVDDFLYLIRKDLPKLNRCRELLAMQEELKQARKAFDVDEKELVD | TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. May be involved in polycomb repressive complex 2 (PRC2) mediated repression. | Q6NQH4 |
Q87SX9 | CYSN_VIBPA | Sulfate adenylate transferase | Vibrio | MNSAVEAQLAELGIEGYLKQHQYKSLLRFLTCGSVDDGKSTLIGRLLHDSKQIYEDQLAAVHSDSQRVGTTGEKPDLALLVDGLQAEREQGITIDVAYRYFSTQKRKFIIADTPGHEQYTRNMATGASTCDLAVILVDARKGILDQTRRHSFISNLLGLKHFVVAINKMDLVDYSQARFEEIRDEYLKFSENLTGDIDIQIIPISALEGDNVVDKGQNLNWFEGPSLLELLETVDVDYEKGAGEFRFPVQYVNRPNLDFRGFAGTVSSGSVKVGDAIKALPSGKTSTVARIVTFDGDIEEAQAGLAVTLTLNDEIDISRG... | With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysi... | Q87SX9 |
Q68W92 | RS8_RICTY | 30S ribosomal protein S8 | typhus group | MSMTDNVADMLTRIRNAYKSKLINVSFPSSKIKNSILDVLQKEGYIKDYVITQKNNISYTKVALKYSINGEASICEIRRVSKPGKRVYSAIKDLKGYYNNMGIYILSTPYGVMSDREAHIKNVGGEVICKVF | One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. | Q68W92 |
Q96EM0 | T3HPD_HUMAN | Trans-L-3-hydroxyproline dehydratase | Homo | MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPGHGKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATGSVFTGKAVREAKCGDF... | Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | Q96EM0 |
Q67S38 | FLOA_SYMTH | Flotillin-like protein FloA | Symbiobacterium | MSMPGLGYLILTFVVLLLLVLFFSFVPVGLWISAAAADVRVGIFYMIGMKLRRVPPHRIVNALIKAEKAGLEISIDKLEAHYLAGGNVDRVIDALIAAQRAGIDLVFERAAAIDLAGRNVLEAVQMSVNPKVIETPVVAGVAQDGIELRAKARVTVRADINRLVGGAGEDTIIARVGEGVVSTIGSAASHKEVLENPDMISRTVLAKGLDAGTAFEIVSIDIADVDVGANIGARLRADQAEAEKVMAQAKAEERRAMAVAEEQEMRAETQRMRAKVVEAEAEVPRALAQALREGRIGVMEYLMMQNLQADTAMREALGGG... | Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity. | Q67S38 |
Q4UP35 | ACSA_XANC8 | Acyl-activating enzyme | Xanthomonas | MADVYPVDPAFAADARITREQYATLYRESIEHPEQFWGKAAQRLDWFKQPTQIKDVSFALDDFHVRWFGDGELNASVNCLDRQLATRGDKTALLFEPDSPDSPSYPVTYRELYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVVFGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVDMQAPRDRWFHDVVDGQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPL... | Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can the... | Q4UP35 |
B0VSP5 | CH60_ACIBS | Chaperonin-60 | Acinetobacter calcoaceticus/baumannii complex | MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKLIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAVAKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTA... | Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. | B0VSP5 |
Q3BSK1 | SST_XANC5 | Serine O-succinyltransferase | Xanthomonas | MTEFIPAGTLYHALPSPFPMKRGGVLHQARVAYETWGTLAADRSNAILIVTGLSPNAHAAANQANPEPGWWEAMLGPGKPIDTARWFVVCVNSLGSCKGSTGPASVNPATGAPYRLSFPDLSIEDVADAAADVVRALGIAQLACLIGNSMGGMTALALLLRHPGIARSHINISGSAQALPFSIAIRSLQREAIRLDPHWNGGHYDDARYPESGMRMARKLGVITYRSALEWDGRFGRVRLDSEQAADDPFGLEFQVESYLEGHARRFVRFFDPNCYLYLSRSMDWFDLAEHVDEQPATDSAIDHAHADALPASAKPQTGV... | Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. | Q3BSK1 |
A8GE00 | RNFC_SERP5 | Rnf electron transport complex subunit C | Serratia | MLNLFAAFKKDRIWDFDGGIHPPEMKTQSSGVPLRTAPLPDKFIIPLQQHLGPEGELCVKVGDTVLKGQPLTVGRGRTVPVHAPTSGTISAITPHITAHPSGLAELCVIIQPDGEDRWCERAPVADYRQLTASELIQRIHQAGIAGLGGAGFPTASKLQGGMNGVETLILNAAECEPYITADDRLMQEHADQVIEGTQILRHLLQPKVTLIGIEDNKPEAIAALKLALRGQPGIALRVIPTKYPSGGAKQLTKILIGKEVPHGKHSSAIGVLMQNVGTAFAIKRAIVDGEPLIERVVTLTGEALSLPGNLWARIGTPVQH... | Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. | A8GE00 |
Q4QLI0 | HLDD_HAEI8 | ADP-L-glycero-beta-D-manno-heptose-6-epimerase | Haemophilus | MIIVTGGAGFIGSNIVKALNDLGRKDILVVDNLKDGTKFANLVDLDIADYCDKEDFIASIIAGDEFGDIDAVFHEGACSATTEWDGKYIMHNNYEYSKELLHYCLDREIPFFYASSAATYGDTKVFREEREFEGPLNVYGYSKFLFDQYVRNILPEAKSPVCGFRYFNVYGPRENHKGSMASVAFHLNNQILKGENPKLFAGSEGFRRDFVYVGDVAAVNIWCWQNGISGIYNLGTGNAESFRAVADAVVKFHGKGEIETIPFPEHLKSRYQEYTQADLTKLRSTGYDKPFKTVAEGVTEYMAWLNRK | Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. | Q4QLI0 |
P17764 | THIL_RAT | Acetoacetyl-CoA thiolase | Rattus | MAALAVLHGVVRRPLLRGLLQEVRCLGRSYASKPTLNDVVIVSATRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTRSKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPI... | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two car... | P17764 |
A7I137 | ATPL_CAMHC | Lipid-binding protein | Campylobacter | MISIYAQIASFSAIGVGIAIGVAACGGGIGMGIAANATILGMARNPSISSKLTTTMYISLAMIEAQVIYALVIVFILLYANPLLTETIAAAAK | Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits. | A7I137 |
B4LYI3 | EI3D1_DROVI | Eukaryotic translation initiation factor 3 subunit p66 | Drosophila | MSETINTAAQFPTFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTSTSNNDKKYQNKYASTFGTGNQYAYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRNSRSGRGRNARGGLNTHGHGMTTLSSKNVKARDPRRGMGKRFGNRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKDGEDITTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTIGNVFATDAILATIMCSTRSNYSWDIVIEKVGEKIFMDKRDHTEFDLLTVNETSVEPPTDDDSSCNSPRNLAI... | mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically target... | B4LYI3 |
C3P8L8 | PRMA_BACAA | Ribosomal protein L11 methyltransferase | Bacillus cereus group | MKWSEISIHTTEEAVEAVSHILHEAGASGVAIEDPAELTKEREQQYGEIYALNPDEYPAEGVLIKAYFPQTDSLHETIAGVKSSIDVLPSYDIEIGTGNITVNEVNEEDWATAWKKYYHPVQISDTFTIVPTWEEYTPSSPEEKIIELDPGMAFGTGTHPTTTMCIRALEKTVQPGDTIIDVGTGSGVLSIAAAKLGASSVQAYDLDPVAVESAEMNVRLNKTDDVVSVGQNSLLEGIEGPVDLIVANLLAEIILLFPEDAARVVKSGGLFITSGIIAAKEKVISEALEKAGFTIEEVLRMEDWVAIIARNA | Methylates ribosomal protein L11. | C3P8L8 |
Q75R63 | NQRB_VIBAN | NQR-1 subunit B | Vibrio | MGLKKFLEDIEHHFEPGGKHEKWFALYEAAATLFYTPGLVTKRSSHVRDSVDLKRIMIMVWLAVFPAMFWGMYNVGHQSITALNHLYSGAELATVISGNWHYWLTEMLGGTLSTQAGWASMMLLGATYFLPIYATVFLVGGFWEVLFCMVRKHEVNEGFFVTSILFALIVPPTLPLWQAALGITFGVVVAKEIFGGTGRNFLNPALAGRAFLFFAYPAQISGDVVWTAADGFSGATALSQWAQGGNGALINKVTGEAITWMDAFVGNIPGSIGEVSTLALAIGAAFIVYMGIASWRIIAGVMVGMIAISTLFNVIGSDTN... | NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. | Q75R63 |
P83234 | VESP_OPHHA | Ohanin | Ophiophagus | MLLFTLCFFADQENGGKALASPPGNWQKADVTFDSNTAFESLVVSPDKKTVENVGVPKGVPDSPERFSSSPCVLGSPGFRSGKHFFEVKYGTQREWAVGLAGKSVKRKGYLRLVPEERIWQKGLWWLRRLETDSDKLQKGSGKIIVFLDYDEGKVIFDLDGEVTTIQANFNGEEVVPFYYIGARVSLANL | Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. | P83234 |
Q94P36 | NU3M_RHIPI | NADH dehydrogenase subunit 3 | Rhinolophus | MNFMLTLLTNTLLALLLVTIAFWLPQTNVYSEKSSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQANNLEVMLTTALLLISLLAISLAYEWSQKGLEWTE | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. | Q94P36 |
Q7RZA5 | MTAP_NEUCR | 5'-methylthioadenosine phosphorylase | Neurospora | MENLPTTYDGPVHIAVIGGTGLSKLEGYVPVAALNPTTPWGSPSSPLMIFEHNGHAVAFLARHGLYHQLAPHEVPARANIAALRSIGVRTIIAFSAVGSLREEIKPMDFVIPDQIIDRTKGIRPFTFYEGGVVGHVGFADPFDAGLAQVVEKCASAMKGDGVVLHNKGTIICMEGPAFSTRAESHMYRSWGGSVINMSALPEAKLAREAELAYQMICMATDYDCWRDEAGEDVDVAMVMKYMAANGENAKHLVGAVLDELLKQDNSDLVLAKKWQGSAQGAVKFMTKPEGRDPEAMKRVEFLFPGFWEQN | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethioni... | Q7RZA5 |
B5EEE7 | YACG_CITBB | DNA gyrase inhibitor YacG | Citrifermentans | MNAITTIKCPQCRKETTLAGNPYRPFCSQRCKMIDLGTWADEGYRIPGEKAPESGDEEPGDE | Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | B5EEE7 |
P65228 | KHSE_STAAM | Homoserine kinase | Staphylococcus | MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEVKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ | Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. | P65228 |
A3PEH8 | RL21_PROM0 | 50S ribosomal protein L21 | Prochlorococcus | MTNSKKSSNNSSKSSELYAIAETSGQQFWFEVDRYYDIDRLNAKEKDKITLEKVLLLKDKDSISVGKPYVKDAKIELEVVSHKRDKKILVYKMRPKKKTRRKMGHRQELTRVMVKSITIGKSAPKSSSKKETVKKETKPKSEKSTN | This protein binds to 23S rRNA in the presence of protein L20. | A3PEH8 |
Q90ZK5 | DRS8_PHYBI | Dermaseptin-gene related 2 | Phyllomedusa | MAFLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSKIKEAGKAALTAAGKAALGAVSDAVGEQ | Has antimicrobial activity. | Q90ZK5 |
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