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2.75k
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AlphaFoldDB
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A7HGZ6
TSAD_ANADF
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
unclassified Anaeromyxobacter
MRILAIETSCDETAAAIVEDGRRALADVISTQIDIHRRWGGVVPELASRNHVVQVMPVVDEALSRAGVGPDGLDAIAVTSGPGLVGALLVGVQAAKALALAWQKPLVRVNHLEGHLVAAFLSETAPAFPYLGLVVSGGHTSLYAAHGFGDYRLLGQTRDDAAGEAFDKGAKLLGLPYPGGVAIDRLAKEGDARAIRFPKAIVKGADLDFSFSGLKTALLHHVKKHGLPEGKGLADLCASYQEAIVRALVEKAFRAARRLQYDRLVLSGGVAANSRLRGAVAERAREYEGMEVFLPAPRLCTDNAAMIAVAGTHAFLRGERAGADLNADPAWRL
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
A7HGZ6
P0CI53
SNAAL_LYCMC
Neurotoxin LmNaTx21.1
Lychas
LILVACLMMSCVHCKKDGYPVDWNNCMYDCGYDNAYCEKICKEKGGESGYCYFWKISCYCEGLPDNVEIKGYGRCRG
Binds voltage-independently at site-3 of voltage-gated sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
P0CI53
P25929
NPY1R_HUMAN
Neuropeptide Y receptor type 1
Homo
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
P25929
P53218
POP6_YEAST
RNases P/MRP 18.2 kDa subunit
Saccharomyces
MINGVYYNEISRDLDISSSTQCLRFLKETVIPSLANNGNNSTSIQYHGISKNDNIKKSVNKLDKQINMADRSLGLQQVVCIFSYGPHIQKMLSILEIFKKGYIKNNKKIYQWNKLTSFDIKREGRNELQEERLKVPILVTLVSDSEIIDLNLHSFTKQ
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
P53218
Q7UN13
RL16_RHOBA
50S ribosomal protein L16
Rhodopirellula
MALMPKRVKHRKSQRGRIKGNATRGNTVVFGDYGIQSLDAGWIKATTIEAGRIAAQQYVRGQGKLYIRIFPDKSVTSTPLETRMGKGKGEPDFWAAVVKPGTILYELSGVTEQQAKVCFARLASKMPVKVRFVERRSA
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q7UN13
P02488
CRYAA_MACMU
Alpha-crystallin A chain
Macaca
MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKIQTGLDATHERAIPVAREEKPSSAPSS
Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
P02488
B9KZW3
RS13_THERP
30S ribosomal protein S13
Thermomicrobium
MARIAGVDLPRDKRIEYALTLIYGIGWTTARKILERTGIDPWTKVRDLTDDEVQRLRDIIEKEMVVEGDLRRQVAMNIKRLIDIGCYRGLRHRMGLPVRGQRTRTNARTRKGPRPRIGVKKKGKQAGS
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B9KZW3
A0RM16
RL22_CAMFF
50S ribosomal protein L22
Campylobacter
MSRAIIKFIRLSPTKARLIADEVQGMNAELALASLSFMPNRGAKYIASAISSAVANGGFEPEEVVVKSCRVDAGPVLKRFRPRARGSASRIRKPTSHILVEVSKPESKEA
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
A0RM16
A1B323
ISPG_PARDP
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Paracoccus
MSHNPIRPWRNIDRRNSRRIMVGNVPVGGDAPISVQTMTNTDTSDVRATLDQIIRAADVGADIVRVSTPDQDSTRALREICRESPVPIVADIHFHYKRAIEAAEAGAACLRINPGNIGDATRVREVIKAARDHGCSIRIGVNAGSLEKHLLEKYGEPCPDAMVESGLDHIRILQDNDFHEFKISVKASDVFLAAAAYQQLADATDAPIHLGITEAGGLTAGTVKSAIGLGNLLWMGIGDTIRVSLSADPVEEVKVGFEILKSLGLRTRGVQIISCPSCARQGFDVIKTVEILEKRLEHIKTPMSLSIIGCVVNGPGEALMTDIGFTGGGAGSGMVYLAGKQNHKMTNAQMVDHIVELVEKRAAEIEAAQSAAAE
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
A1B323
A0QX88
HIS3_MYCS2
Phosphoribosyl-AMP cyclohydrolase
Mycolicibacterium
MSLDPAIAARLKRNADGLFAAVTQERGTGKVLMVAWMDDDALARTLQTREATYFSRSRGEQWVKGATSGHTQKVHSVRLDCDGDTVLLEVDQVGGACHTGDHTCFDADLLLGPDE
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
A0QX88
A2XED8
G1L7_ORYSI
Protein G1-like7
Oryza sativa
MDPSGPGPSSAAAGGAPAVAAAPQPPAQLSRYESQKRRDWNTFLQYLRNHRPPLTLARCSGAHVIEFLRYLDQFGKTKVHASGCAFYGQPSPPGPCPCPLRQAWGSLDALIGRLRAAYEESGGTPESNPFAARAVRIYLREVRDSQAKARGIPYEKKKRKRSQAAQPAGVEPSGSSSAAAAAAGGGDTGSGGGAAATTTAQPGGSGTAPSAS
Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light.
A2XED8
B9L8G5
CMOB_NAUPA
tRNA U34 carboxymethyltransferase
Nautilia
MDINKVLKERQKWFEWKNIKPIYEKIVQWQIENKQLNVKNVKLNDIIEITLDENKEKLKEIEQIAKMLKPWRKGPFKINDLFIDTEWRSFIKWNIIKPHINLENKDVLDVGCNNGYYMFRMLEMNPKSITGFDPSALFNLQFEFINNFIKSDIEYKLLGVEHIPFYDKKFDTIFCLGVLYHRPDPITMLKELKAGLNPGGEVILDTLIIEGDEEIALCPVRYQKMKNVYFIPTLKALYNWIEKAKFKDVKFIGKRYTDLEEQRKTDWIEGESLNNFLNEDLTKTVEGYPPPLRVYLKLKN
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
B9L8G5
P11139
TBA1_ARATH
Tubulin alpha-1 chain
Arabidopsis
MREIISIHIGQAGIQVGNSCWELYCLEHGIQPDGTMPSDSTVGACHDAFNTFFSETSSGQHVPRAVFLDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTVGREIVDTCLERLRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDFGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVVVLLDNEAIYDICRRSLDIERPTYSNLNRLISQTISSLTTSLRFDGAINVDITEFQTNLVPYPRIHFMLSSYAPVISSAKAYHEQFSVPEITTSVFEPSNMMAKCDPRHGKYMACCLMYRGDVVPKDVNTAVAAIKAKRTIQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGGEGAEDDDEEGDEY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P11139
B2IW30
COFH_NOSP7
FO synthase subunit 2
Nostoc
MLTKIAVEKILERALMGYDLSPQEGVVLLQQTEPEAIAAIRATSDTLRHTQAGDMVTYIINRNINFTNICEQHCSFCAFRRDDGDVGAYWLDSAQILEKATDAVRRGATEICMQGGLNPQAQINGKSLPYYLKVVETIKQEFPQIHLHAFSPQEVEFIARLDGLEYADVIIALRDAGVGSMPGTAAEVLDDEVRRILCPEKINTATWLGIVSTAHKLGLHTTSTMLSGHIETHEQQIGHLEKLRSLQQTAINQGYPAKITEFILLPFVGQEAPKPLRRRVGRDQPILSDALLLGAVARIYLGNWIPNHQQSWVKLGLAGATEALVWGCNDIGGTLMEEHITTMAGALGGTCMEVETLKTAIASLGRPYQQRNTLYQKVNS
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
B2IW30
Q2NDC1
CLPX_ERYLH
ATP-dependent Clp protease ATP-binding subunit ClpX
Erythrobacter
MTKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRKEGDVPAPSEICATLNDYVIGQDRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGPTGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVENIILKLLQASDYNVDKAQHGIVYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIPEFVGRLPVIATLHDLDVDALVTILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERAILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADVVEGKKEPIRVVSNDDDGKKEEAA
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Q2NDC1
A7H0Z1
RS11_CAMC5
30S ribosomal protein S11
Campylobacter
MAKRKIVKKKVVRKSIAKGIVYISATFNNTMVTVTDEMGNAIAWSSAGGLGFKGSKKSTPYAAQQAVEDALNKAKEHGIKEVGIKVQGPGSGRETAVKSVGAVEGIKVTFLKDITPLAHNGCRPPKRRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
A7H0Z1
B4F7E8
NIBA2_RAT
Protein FAM129B
Rattus
MGDVLSTHLDDARRQNIAEKTEKILREFLRFYEDQYGVSLFNSMRHEIEGTGPPQAQLLWRKVPLDERIIFSGNLFQYQEDNKKWRNRFSLVPHNYGLVLYENKVAYERQIPPRAVINSAGYKVLTSLDQYLELVGNSLPGTTSKSGSTPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCVRHCNNGIPENSKVEGPAFTDAIRMYRQSKEQYGTWEMLCGNEVQILSNLVMEELGPALKTELGPRLKGKPQERQRQWIQISDAVYRLVFEQAKVHFEEVLCKLQLARPAMEAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSQLAYHPLKMQSCYEKMEPLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRILERVLKKYDYDSSSVRKRFFREALLQITIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSVVLHNSDPNLHLLAEGAPIDWGEQYGDGGDGSDSGGSPCPSEAATLTEKRRRAKQVVSVVQDEESGLPFEAGSEPPSPASPDNVTELRGLLAQDLQAESSPPASPLLNGAPVQESPQPMTVLEASPPASPLRHLPPGKAVDLEPPKPSDQETGEKVSSPGSRPPIHTTTEDSAGVQTEF
May play a role in apoptosis suppression.
B4F7E8
C0MF07
RF1_STRS7
Peptide chain release factor 1
Streptococcus
MNIYDQLQAVEDRYEELGELLSDPEVVSDTKRFMALSKEEASTRETVAAYRQYKAIIQSIDDAEEMIKEAGGDPDIEEMAKEELKEAKAAKETYEDKLKLLLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLAMYQKFAESQGWRFEVMEASYNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKLDEIVDALVLYDQTQKLESLNNQ
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
C0MF07
B1JSU1
GPMA_YERPY
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Yersinia
MAVTKLVLVRHGESQWNNENRFTGWYDVDLSEKGRSEAKAAGKLLKDEGFTFDFAYTSVLKRAIHTLWNILDELDQAWLPTEKTWKLNERHYGALQGLNKSETAEKYGDEQVKQWRRGFAITPPALEKSDERFPGHDPRYAKLTDAELPTTESLALTIERVIPYWNDVIKPRIASGERVIIAAHGNSLRALVKYLDDLGEDEILELNIPTGVPLVYEFDENFKPIKHYYLGNADEIAAKAAAVANQGKAK
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
B1JSU1
A8F791
SYE2_PSELT
Glutamyl-tRNA synthetase 2
Pseudothermotoga
MTVRLRFAPSPTGYLHVGGARTALFNWLYARKMNGKFVLRIEDTDLQRSTKESEKAIIESLKWCGIDWDEGPDIGGDFGPYRQSERVSEGIYKRYAQILVEKQCAYYTVYDKVDRKKVLFNTFEYPEEYEKKGHDITISFRVPEGITKFHDLLKGNMEFQNSVIGDFVIVKSDGFPTYNFAVVIDDYLMRITHVFRGEDHLSNTPKQIMIYKALGWEIPQFMHIPLILGFDRTPLSKRHGATSVEHFRKIGILNMGLMNYLALLGWSVGEEEVFDVKEKLVNFEPESISNKGVIFDPEKLEWVNGKHMRMINIEQLWNEFVEWIKFTNRKIPHCEESYALKVLNVCREKVNTLSQLYDFSYSFFFDDYTLEERFVSEYLSTSYAKEILRKAVVLFSELKDWSIEGTEKVCRALADMKIASKNKVFQLLRGAVTGKLVTPGLFETLSILGKKRVIERFEKLLNSVDC
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
A8F791
Q5FMB2
ALR_LACAC
Alanine racemase
Lactobacillus
MVPGYHRPAAVKVNLGAIRRNLENEMKHLDPGQKMLAVVKANAYGHGAVEVAKVAEEVGAAGFCVAVLDEGLQLRHADIVKPILVLGVVSPKYAPIAAVNNISLTVPNFEWLKEAEKYLAKENLQLKIHLGIDSGMGRIGFNEDDEFIEANKFLENNDQFFVEGMFAHFASADSADESYFEHQLEKFNHMKSLLTVKPKWIHVSNTAASIFHKNIKSDLVRFGIGIYGLNPSSNPASADLNPDIKLEPALSFESELTHVKTIHKGDGVSYGSTFVADKDTIIGTVPVGYADGWIRKFQGFKVKVGDKYCPIVGRICMDQFMVELPEKMPVGTKVVIISNNPDDPNNIKAAADYVNTIHYEVACLLNDRLPRIYYEK
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Q5FMB2
A0A3G9HRC2
ALT2_ALTAL
NADPH--cytochrome P450 reductase
Alternaria alternata complex
MAISSPSQARSVGNPSPRCVKSSTYPFLGNILDIDPDNFTKSLGDVYMINYGSYRDVIVTSRKVAQELCDESRFCKLPGGAIDRMKRVIGNGLFTAETRDPRWQSAHRVIAPLFNPMRIRGMMDDMRDVCEQMCLRWARFGPGVPIKICDEMTKLTLDTIALCTVDHRFNSFYRPDGIEEPFAEAVVNVMTDSLIQSNLPDWINNWVRFRSMNKFNRQADELRHAIEELIESRRKNPVDRNDLLNAMLSHEDPETGQRLSDELVVDNLLTFFIAGHETTSSLLSFCMYYLLECPDVLQKARAEVHATVGTSTIMPEHLSKLPYLESVLRETLRLRDPGPGFFVKPLRDDVIAGKYFVKKDQSIFIVFDSVHRDPDVYGDDADEFRPERMSQEKFDQLPPCAYKPFGNGVRACIGRPFAMQQAILAVAMILQHFDLIKDESYKLKIHVTMTVRPIGLTMKVRPREGLRATDVNLRMHQASGTATPKPLASGTDGSMLTVTKNGPMHLAIVHASNSGTSEALAGLLASNAVDRGLGVKSISVANDIVEKLPRDVPVVIITASYNGEPSRNAADFVSWLKSTKQHELEGVRYAVFGCGHRDWASSLFAVPKLIDSLLSTNGAEQIAQMGTSDTGGSTDIYSDFEDWTTKFLFPYLNSKQEMKDTKLNSGADTRDVDLHVSLGKPPRVAMRKGFAAATVTKNRSLSAPGVPEKCELELCLPDGFTYKAGDHLQILPRNSSNDVQSVLRHFHLEAETLVSIQSAHRNKRLGLPLDVPIMASELFAAYVELGRTASSRNIHVLAGLVRSDKPKIKRILLSLANGESYKTEVLDKRISVLDLLKQFPDIEISLAGFLSLLMPIRPRSYSFSSGPNWKPGFATLTYTVVGAGKLVSKAKMTEHVAMSMRGGLASTFLSTLSARDDLYVSLDPASPSFYDDQSVSCPIIMIAAGTGIAPFIGFLQERKLSLAHTALLQGSKKAGPYARTLLFFGCRGPALDSLYTEELAAFEADGLVEVRRAFSRDHTAAGSNGCKYVDQRLAASAEELVELWRLGARVFVCGGKKMANNVFDVLGPLFHEADKLDQKTAEDDVGKWRTTLGKGRYAEEIFI
Bifunctional cytochrome P450/NADPH--P450 reductase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype . The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units . ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin . The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable). This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable). The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable). The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref.5).
A0A3G9HRC2
Q15345
LRC41_HUMAN
Protein Muf1
Homo
MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPNAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKKGARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Q15345
Q11PK1
KUP_CYTH3
Probable potassium transport system protein kup
Cytophaga
MSTIADSKNHGHQKLTAAGLLISLGIIYGDIGTSPLYVMKAIAGGNVISENLILGGLSCVFWTITLQTTIKYVIITLRADNKGEGGIFSLFALIRRRNPNLVWPAMIGGAAMLADGIITPPISVSSAVEGLLIFNKDIPTIPIVLAIIVMLFMIQRFGTNIVGKFFGPIMFIWFAMLATLGLSQLMGNFYVLKAINPMYAFNLLTQYTTVDDKSGFWLLGAVFLCTTGAEALYSDLGHCGRPNIRISWIFVKLALLINYFGQGAWILQNKGYVIKGNPFFGIMPEWFIVYGIIIATMAAIIASQAMISGSYTLISEALRLNLWPKVRVKYPSVKKGQLFIPSINLLLLAGCIFVVLWFGESSAMEGAYGLAINITFLMTTILLAYYLLIIKRISFIWVGLLILMYLIIEVSFLVANLEKFFHGGYFTLISSGILAFIMIIWYTAHRIKRRLTEYVKIQDYFPLIKELSEDTSIPKYSTHLIYLTGADNYTQIESKVIYSIFQKQPKRADIYWFLHIDVVDEPYTMEYKVRTMLADDVIRIDFKLGFRVEHRINLFFRKVVEDMVNNKEVDFTSRYTSLNKRNVIGDFRFVVLEKHLSNDNDLSVMEQFAMDWYFFLKHISISESSAFGLDTSSVTVEKVPMVISPMEAFQLKRVY
Transport of potassium into the cell.
Q11PK1
B8HXS4
DEOC_CYAP4
Phosphodeoxyriboaldolase
unclassified Cyanothece
MVAPSAEIDLAPYIDHTLLDPLATPAAIAQLCEEADRYHFATVCLAPIYVRQAVELLYRRTPRVCTVIGFPTGAHTSAVKLYEAQEAADHGATELDVVVNLGWLKAGQTEAVHQEMAEIVAATGVTVKAILETTVLSETEKRLAAEICLDAGVSFLKTSTGWRGGATVADVKLLAQVARDRIGVKASGGIRTAAQALELIHAGATRLGTSRGVDLIRNRDTLEGETNY
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
B8HXS4
Q8DBD5
RNH_VIBVU
Ribonuclease HI
Vibrio
MTKQVEIFTDGSCLGNPGPGGYGVVLRYKQVEKTLAQGYRLTTNNRMEMMATIVALQALKEPCNVILTTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNADLWQALDKETTRHTIDWRWVKGHAGHRENEMCDELARAAAENPTLDDTGYQPAE
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q8DBD5
Q31GZ0
HIS1_HYDCU
ATP phosphoribosyltransferase
Hydrogenovibrio
MADQLTIALSKGRIYKDTLPLLEAANIIPQEDPSKSRKLIIPTNHEHVRLLIVRATDAPTYVAHGAADIGVAGKDVLMEAPSDNLNELLDLQIAKCKLMVAGPKEAKPHGHRLKIATKYIQSAKAYYAQKGQQVDLIKLYGSMEIAPLIDLADKIVDLVDTGNTLKANGLVPEEHIADISSRLIVNEHAYKTKFKQINDIVEKFRSAI
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Q31GZ0
Q2G9P6
MIAB_NOVAD
tRNA-i(6)A37 methylthiotransferase
Novosphingobium
MSSSAPSSASPKTFRVKSFGCQMNVYDGERMAELLAAQGMSAAGDGDDADLVVLNTCHIREKATEKVYSDIGRLRRADGSAPLIAVAGCVAQAEGEEIMARAPSVKVVVGPQSYHRLPEMVADAAAGKRSTETDMPAEAKFAALPKRRKSAPTAFLTVQEGCDKFCTYCVVPYTRGAEISRPFSDLVEEAKLLVAGGAREITLLGQNVNAWAGEDDKGRPIGLDGLARALAAEPDLKRIRYTTSHPNDMTDGLIAAHGELEKLMPFLHLPVQAGNDRVLKAMNRSHTADSYMALLERIRAARPDIALSGDFIVGFPGETDAEFEDTLRLVDAVGYAQAFSFKYSARPGTPAATMENHVPVAVMDERLQRLQAALNRDQLAFNKASVGKTCEVLVERRGKHPGQWLGKSPWLQSVHFSGEAEIGDMVTVELIEAGPNSISGRLA
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q2G9P6
Q2GI13
SYY_EHRCR
Tyrosyl-tRNA synthetase
Ehrlichia
MKLESQFLSFLYSRGYCSQCTNISMLDQLMSQQCVHAYIGFDCTAKSLHVGSLIQVMILRHLQKFGHKPIILLGDGTTKIGDPSGKDKSRAMLSASEIEENALGIYEVLKKFIVFGDGPHDALLVRNAEWLNGLNYIEFLRDIGKHFSVNNMLTFDSVRLRLEREQNLSFLEFNYMLLQSYDFVELNRRYNCLLQIGGSDQWGNIVSGVELGRKLRLPELFGLTTNLLLTSSGEKMGKTAQGAVWLDGNMYSPVDYWQYFRNVKDEDVGRFLRLFTELSLNEIRNLELLQGHEINESKKILATEATRICHGEEIAQSVANDALKVFECNDDSGLSVFYVKKYDVELGLPIIKLLQMCEMEKSSSSARRLINDKGCKINDVVVLDMNYKLSLKDFYNTSYVKLSCGKKRHLKVMLESDF
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Q2GI13
Q91V45
KISSR_MOUSE
Metastin receptor
Mus
MATEATLAPNVTWWAPSNASGCPGCGVNASDDPGSAPRPLDAWLVPLFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPAWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCCRQRQRRPHTSAHSDRAATHTVPHSRAAHPVRIRSPEPGNPVVRSPCAQSERTASL
Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Q91V45
Q70KF0
DOIAD_MICEC
2-deoxy-scyllo-inosamine dehydrogenase
Micromonospora
MGGRMRALQFHGGHKAQIIDTPRPEAPPGWAVVKVHYCCLCGSDLWLYRGKWHGNRYPIVPGHEWAGVVDSAPEGYESWVGRPVTGDLIVGCQGCGPCRDGLPVMCENLIEIGFTVDGGCAGYVAVPITNLYLLPEGMDLAAASQTEPLAVALHAVDRINLRPAERVAVLGAGGIGQLILQSARATGATVTLATDLVAERRKIAEESGAAAAVHPSELPELTSYADKVDVVFEASGDPESVVRALDLVRPGGRVCLVGYQVGAEHALETARLPLSYASLVGVMGPGGKYREAVDLLANGAIDTQPILTDIVTLDDYAPAIDRAINRTDGTVRVVFDLRNE
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).
Q70KF0
P59265
PA2BB_PROFL
Phosphatidylcholine 2-acylhydrolase
Protobothrops
HLLQFRKMIKKMTGKEPIVSYAFYGCYCGKGGRGKPKDATDRCCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFCTDPTEGC
Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities. PLA-B is three times more active than PLA-A in edema-inducing activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
P59265
A4G2T6
RIMM_HERAR
Ribosome maturation factor RimM
Herminiimonas
MKVPEDLVLVGYISGAYGLNGWVRVRPYSADADALLNAKTWWLDKPEFRDVAMMQSKIHSGDVVAQLMGVAGRDAAEALKGATVQIPRSHFPALSDNEFYWVDLIGLEVENLQGVRLGQVSDMMDNGAHPILRVAVPQTSEADPKAAQELLIPFVEQFVITIDQTAKKITVDWGLDY
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
A4G2T6
Q3AH76
EX7L_SYNSC
Exodeoxyribonuclease VII large subunit
unclassified Synechococcus
MSADRLPSYSVAELNTAIGSLLERGFAPRFLLEATVSRPQLKKGHLWLTLTDGSASISGVVWASKLAQLSYQPKDGDGVTVVGKLNFWAARASLTVQALDIRPSLSTVLRDFERVRQVLEQEGVIDPSRLRPLPSQPASIAVLTSVPSSALADMLRTAAERWPLTQLIVVPIPVQGSVAPTIINTLEAIAERTAELGLQALVLARGGGSREDLAVFDNEALCRLLANYPIPVVTGLGHEDDLTVADLVADHRAATPTAAIVALLPDREAERQGLTQRQSRLKDTLLGRILRERQRLQDRAVALQQQSPREKIMRKRQELIQKHQLLKALSPERWLKRGLALISNKAGDPIPGLESVKIGDQLNIRMSDGSLEARVDQIQPSAPNTTS
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q3AH76
Q41065
IBBA_PEA
Seed trypsin/chymotrypsin inhibitor I
Pisum
LSFAANVVNARFDSTSFITQVLSNGDDVKSACCDTCLCTKSNPPTCRCVDVRETCHSACDSCICAYSNPPKCQCFDTHKFCYKACHNSEVEEVIKN
Inhibitor of trypsin and of chymotrypsin. May function as a natural phytochemical defense against predators.
Q41065
A6Q200
NDK_NITSB
Nucleoside-2-P kinase
unclassified Nitratiruptor
MERTLSIIKPDAVAKNVIGKIIDRFETNGLRIAAMKKIQLSKNDAAKFYEVHKERPFFNDLVDYMTSGPVVVMVLEGENAVAKNRELMGATDPKEAKPGTIRADFAESIEANAVHGSDSLENAQKEIAFFFAQREIL
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
A6Q200
A2Q898
MCR1_ASPNC
Mitochondrial cytochrome b reductase
Aspergillus subgen. Circumdati
MFARQAFRCAQPLKQGFRKYSTEAPKGKSSLAPIYAAVGITGVGVGLYRYNSATAEAPAAVDRPKVFKGGDQGWFDLKLSEIEVLNHNTKRLRFEFEDKEALSGLQVASALLTKFKPADAKAVIRPYTPTSDEETPGYIDLVVKVYPNGPMSEHLHSMNVGQRLDFKGPIVKYPWETNKHNHICLIAGGTGITPMYQLAREIFKNPEDQTKVTLVFGNVKEEDILLKKEFEELENTYPRRFRAFYVLDNPPKEWTGGKGYISKELLKTVLPEPKEENIKIFVCGPPGMYKAISGTKNSPTDQGELSGILKELGYSKEQVFKF
May mediate the reduction of outer membrane cytochrome b5.
A2Q898
A6RSH5
DBP7_BOTFB
ATP-dependent RNA helicase dbp7
Botrytis
MADDGMLMNFEIGDVPIVAKQAFKGGRWKDRLAAKKTAQHRVTKSTNKPSAREIFSEPQHDTSAEEYIGREASSRAPKRQRVDDNYNSYGGRNENTAAYASGKLPSGSINVGGGRKTTFQEEPRTAFVAGKLPPGSINIGGKKATQIEDEGRAAYASGKLPPGSINSGAKKAISFQDETRPAYVSGKLPHGSIDGMRNREMAAVHREIAEGGRKPGQVVSSLFTFNPTSKKTFDEPEEQAEPAKPSNAPLTEEMATFTNLGLSRRLAAHLSTKLDMKAPTAIQKASVQQLVSDDSDAFIQAETGSGKTLAYLLPIVERILALSENGVQIHRDSGLFAIILSPTRELCKQIAAVLEKVLRCAPWIVGTTVNGGESKQSEKARLRKGVNILVATPGRLADHLDNTEVLNVATVRWLVLDEGDRLMELGFEEEIKGIVEKIGRRSVAKANSDMGSLPKRRVTILCSATMKMNVQRLGEISLKDAVHIQADPSEQEKQDKENGVEAQDKAFSAPTQLKQSYAIVPAKLRLVTLTALLKRAFARKGSVMKAIVFISCADSVDFHFSLFSRTPEASAEVVDEEKVDLPALPKSELVKETIAHGTTISNNSNPVILHKLHGSLAQNIRTATLKAFSESADPCVMICTDVASRGLDLPNVDFVIEYDPPFSAEDHLHRVGRTARAGREGRALIFLMPGVEEEYVSILASGYREGKKALTRHTAEDLIQKGFGGIGREWEERATNFQLEVERWSLDSPKYLEMARRGYQSHIRAYATHVANERHIFNMQELHLGHLAKAFALRDKPGSIKVPGLRPAKMTKADRSVAARKAKRGEKAEDKAPEGERVRKQKKMELDLPTVDGNEAAARMKRKMKEHMAAASEFNIG
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
A6RSH5
Q5SQN1
SNP47_HUMAN
Synaptosomal-associated 47 kDa protein
Homo
MRAARRGLHCAGAERPRRRGRLWDSSGVPQRQKRPGPWRTQTQEQMSRDVCIHTWPCTYYLEPKRRWVTGQLSLTSLSLRFMTDSTGEILVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIEHFWRELLLSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESDLEVADRLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVISHRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKPDMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSARTSSPAEKSCSVWHAASGLMGRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRRMKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT
Plays a role in intracellular membrane fusion.
Q5SQN1
Q2KHY1
CPNE6_BOVIN
Copine VI
Bos
MSDPEMAWVPEPPAMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLHSDEQWVEVERTEVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGSTSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKNAGKSTITIVAEEVSGTNDYVQLTFRAHKLDNKDLFSKSDPFMEIYKTNGDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKHYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAGPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGTLRCPRGVPAARDIVQFVPFRDFKDASPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTPAMTPSPSP
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes.
Q2KHY1
Q12IL8
KGUA_SHEDO
GMP kinase
Shewanella
MSARGNLFIVSAPSGAGKSSLITALLKDKPQDMQVSVSHTTRAPRPGEVDGQHYHFVSVEQFKALIAENAFFESAEVFGNFYGTSRQVIENTLSLGIDVFLDIDWQGAQQVKKIMPEAIGVFILPPSKAELERRLTGRGQDSSDVIAARMAQAVSEMSHYNEYDFVIINDDFEQALADLKSIIFSQRLTCASQFHTHNDMLVDLLAD
Essential for recycling GMP and indirectly, cGMP.
Q12IL8
Q3ZM03
RSSA_XENLA
Laminin-binding protein precursor p40
Xenopus
MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVCVISSRNTGQRAVLKFASASGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPITEASYVNIPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKATTKEEFQGEWTAPVAEFPQAEVADWSEGVQVPSVPIQQFTAERTDVPPAPKPTEDWSTQPASTDDWSAAPTAQASEWTGTTTEWS
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
Q3ZM03
P0AA29
THIO_SALTI
Thioredoxin 1
Salmonella
MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
P0AA29
B3H1B5
PYRD_ACTP7
Dihydroorotate oxidase
Actinobacillus
MYSLIRKCLFSMDAETAHNFSIQALKLAGKLPINVLPMPLNPVEVMGLQFKNPIGLAAGADKNGEAIDGFGKLGFGFIEVGTVTPVAQDGNPKPRQFRILEAEGIINRNGFNNLGVDVLVENVKKAKYDGIIGINIGKNAVTPIERALDDYQICLRKVYEHADYITVNISSPNTKNLRTLQYGEALDDLLRSLKSEQESLSQKFNRYKPLVLKIAPDLTDEEIASVADGLIRHKIDGVIAGNTTLSRDPVVGLKNAEQQGGLSGKPLNTLSTRLISTLAEELNGTLPIIGSGGIHSVASGQEKIDAGASLLQVYSAMIYQGLALIQNLAKHIQVR
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
B3H1B5
A8LC60
RS7_FRASN
30S ribosomal protein S7
unclassified Frankia
MPRKGPAPKHPVVVDPVYGSPLVTALVNKVLLSGKKSVAERIVYGALEGAKNKTGNDPVVTLKRALDNVKPTLEVRSRRVGGATYQVPVEVRAGRSTTLALRWIVGYSRGRREKTMTERLMNELIDASNGLGASVKRREDTHKMAESNKAFAHYRW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
A8LC60
D9S0S1
CBIM_THEOJ
Energy-coupling factor transporter probable substrate-capture protein CbiM
Thermosediminibacter
MRKITFIAALLSLLPRYALAMHVMEGFLPFKWCLLWYSIYIPFLMAGLIYIKKNIAEEPSKKILLGFAGAFVFALSALKLPSVAGSSSHPTGIGLGAILLGPLPMAVIGGIVLLFQALLLAHGGITTLGANAFSMAVAGSFAAYGLYKVAGRVGLSKSASVFLGAASGDLMTYIITSLQLALAFPASRGGVAASFAGFSGIFAVTQLPLAIGEGILTVIVLNLLEIHAGVVVGRLVKGASNDEG
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
D9S0S1
Q2KID7
OSTC_BOVIN
Oligosaccharyltransferase complex subunit OSTC
Bos
MESLYRVPFLVLECPNLKLKKPPWVHMPSAMTVYALVVVSYFLITGGIIYDVIVEPPSVGSVTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Q2KID7
B2U8X6
PXPA_RALPJ
5-oxoprolinase (ATP-hydrolyzing) subunit A
Ralstonia
MTAIDLNADLGEGCDTDEALLALVSSANIACGWHAGDVNTMRQTVGWALRQGVSIGAHPSFPDRENFGRTEMHLQPDEIYAGVLFQIGGLSAIVRAQGGKLAHVKAHGALYNQASRDRPLAMAIVHAIRDFDPSLVVFGLAGGELVKAARELGLQAKEEVFADRGYNADGSLVKRGTPGALIDSEDAALDQTLTMVREQRVKAIDGTWVPIRAETVCLHGDGAHALAFARRIRERLGSEGIAVRAGA
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
B2U8X6
Q96EX3
DC2I2_HUMAN
WD repeat-containing protein 34
Homo
MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Q96EX3
Q7M3B6
HBA_SAGMY
Hemopressin
Saguinus
VLSPADKSNVKAAWGKVGGHAGDYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVALVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPADFTPAVHASLDKFLASVSTVLTSKYR
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
Q7M3B6
O23116
EIL3_ARATH
ETHYLENE INSENSITIVE 3-like 3 protein
Arabidopsis
MGDLAMSVADIRMENEPDDLASDNVAEIDVSDEEIDADDLERRMWKDRVRLKRIKERQKAGSQGAQTKETPKKISDQAQRKKMSRAQDGILKYMLKLMEVCKVRGFVYGIIPEKGKPVSGSSDNIRAWWKEKVKFDKNGPAAIAKYEEECLAFGKSDGNRNSQFVLQDLQDATLGSLLSSLMQHCDPPQRKYPLEKGTPPPWWPTGNEEWWVKLGLPKSQSPPYRKPHDLKKMWKVGVLTAVINHMLPDIAKIKRHVRQSKCLQDKMTAKESAIWLAVLNQEESLIQQPSSDNGNSNVTETHRRGNNADRRKPVVNSDSDYDVDGTEEASGSVSSKDSRRNQIQKEQPTAISHSVRDQDKAEKHRRRKRPRIRSGTVNRQEEEQPEAQQRNILPDMNHVDAPLLEYNINGTHQEDDVVDPNIALGPEDNGLELVVPEFNNNYTYLPLVNEQTMMPVDERPMLYGPNPNQELQFGSGYNFYNPSAVFVHNQEDDILHTQIEMNTQAPPHNSGFEEAPGGVLQPLGLLGNEDGVTGSELPQYQSGILSPLTDLDFDYGGFGDDFSWFGA
Probable transcription factor that may be involved in the ethylene response pathway.
O23116
Q8W4H8
GDL19_ARATH
Probable myrosinase-associated protein GLL23
Arabidopsis
MMAKNCNLVSVLCVFLVLTLFNKPITVAGQNIPAVGLFTFGDSNFDAGNKQTLTKTLLPQTFWPYGKSRDDPNGKFSDGLIAPDFLAKFMRIPIVIPPALQPNVNVSRGASFAVADATLLGAPVESLTLNQQVRKFNQMKAANWNDDFVKKSVFMIYIGANDYLNFTKNNPNADASTQQAFVTSVTNKLKNDISLLYSSGASKFVIQTLAPLGCLPIVRQEFNTGMDQCYEKLNDLAKQHNEKIGPMLNELARTAPASAPFQFTVFDFYNAILTRTQRNQNFRFFVTNASCCGVGTHDAYGCGFPNVHSRLCEYQRSYLFFDGRHNTEKAQEMFGHLLFGADTNVIQPMNIRELVVYPADEPMRESWVPPTSATVQLRESRGYEYY
Involved in the control of the PYK10 complex size and possibly substrate specificity. May be exported from the endoplasmic reticulum upon interaction with MVP1.
Q8W4H8
Q2U6N1
NACB_ASPOR
Beta-NAC
Aspergillus subgen. Circumdati
MLNRSPSGTAFDHENGKLTHTYPQCIISPSSSHTRSTPNSYKPDHESTRLTNSLKNRGKGTPRRKVKKVHKSSGADDKKLQATLKKMNVQPIQAIEEVNMFKEDGNVIHFGAPKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKNQAGAEGKKDDDEDDIPDLVEGENFESNVE
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
Q2U6N1
B2A0B9
RLMN3_OPITP
tRNA m2A37 methyltransferase 3
Opitutus
MKFTPAKPPLTGETLESLTARLRERGEPAFRASQILDWVYKKRARSWDGMTNLPKPLRTWLDDTFDLMPATLVLNKQSADVTDKLLLELRDGSLIETVIIRAPQEGVGQDHSRKTICISTQVGCAMGCVFCASGLAGLKRDLSAGEIVAQLLQVCYREDALTPRAHMELASFDNIVVMGMGEPLANYDALIRALTILNADWGLGFGARRITVSTSGLVPKILQLADEPLGFRLAISLHGATDEVREKIMPVNKAFPLAKLLPAVKAFSEKHGRMITLEFILIDGVNDSLEQAEKLRDIALDLHAHVNLIPYNTVEGLAWKRPSITRQERFADVLRARRVSVTLRREKGHDIDAACGQLRLKTEKERQVLAAAKT
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
B2A0B9
Q3J818
AROE_NITOC
Shikimate dehydrogenase (NADP(+))
Nitrosococcus
MPDRYAVMGNPIAHSKSPQIHTAFAQQTGQALTYTGLQVEAGKLAEAITAFQQQEGKGLNITIPLKAEAWRLVDQCSPQAQRAKAVNTILLEKNGALLGDNTDGVGLVRDLINNHGGRITGQQVLLLGAGGAASGVIEALLKEHPSHLIIVNRTPAKAIELAARFSPFGAITGGGYELLENNSFHLIINATASSLQGELPPLPRGILRSGGWVYDMMYGNEPTIFMKWGQTHGAARSLDGLGMLVEQAAEAFFIWRKVRPKSAPIIAQLRREMDIKNPAMPL
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Q3J818
A6UP86
GLMM_METVS
Phosphoglucosamine mutase
Methanococcus
MKLFGTSGIRMKNLDPLIAYKVGFAISKNFKKAVIGRDTRTTGNLIESAITAGLLNGGCDVTILGIVPTPVLGFSAKSHDIGIMITASHNPPEYNGIKLFNNNGTSFTPNQEESLEEIIEKSDFLDPSWDIVGNVSEDKTAVKKYLDYILSNINIKKKFNVVVDCANAAACGISPNLFTNAGCKVISVNSHCDGRFVGRMPEPNEKNLVETVDIVKGLNLSGRDFIGIAHDGDADRMIAIDEMGRVTDFDKLLAAFCKYVVQKTNAKKIVTTVDASMAIEEYLKEFGAEVIRTKIGDVSVAYEIEKTGAIFGGEPSGTWIHKSIHLTPDGILSGLRVLEMMEFYDKRLCEIMDEVPSYINLREKLPCPDELKNKVMKYVSKEGKLLFKKEPETLDGVRFSFENGWILIRPSGTESYIRVRVEAKDETFANELLNNGISLVNNGILK
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
A6UP86
B2S670
RS17_BRUA1
30S ribosomal protein S17
Brucella
MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLQKTVRQSKKYKAHDENNQFKVGDFVSIQESAPISKDKRWVVLTSEAAG
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
B2S670
Q6BUX9
HSV2_DEBHA
SVP1-like protein 2
Debaryomyces
MNTLSAISNNKQSKELQILNINFNQDQGCFAVGHEYGFLVYNTNPIDIRVKRNFNINGHGSGIAHITMLHRTNYLALVGGGKNPKFANNKLVIWDDLKRKNSLNLEFMSPVLNVLLSRIRIIVVLKNQVLVYGFSSPPKKFATYETIENEFGLADLSVNFTNSIGNNLSTSNSSISSLVSNQVSYDSNKYQTLAFPGRSIGQIQIVDVSPSGQEKNLVSIIKAHKSKIRCLALNRSGTLVASASETGTIIRVHSTHNTALLYEFRRGLDRAIVTSMKFSHDDSKLAVLSDKNTLHVYNVSPLNTSSGATSDLVTHNETYPVNRSHLLGSIAFPIPIPKYFKSTWSFCSVNTNKYHPSGSDNDTINDVGIIGWSGNDSIIIIWQNKKIWEKYVIVEKRNKYLGDINDGLNTSHQGSSNWELVRFNWKNLDNLD
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
Q6BUX9
A0LIZ1
MTNA_SYNFM
S-methyl-5-thioribose-1-phosphate isomerase
Syntrophobacter
MPQQWLPPIYWDGDAVAILDQRLLPQREAVIRCTSPKQVVAAIKNMAIRGAPAVGVAGAMALALGAVLIQAADARTFKSKFARLCRQVRTARPTGRNLGWAVDRIHALVEGNRDADVPRLHELIRREADLILAEDVAGNVAIGSWGKTVIPRGAGIMTYCNAGALATADYGTAVGVIRAAFDADPGIRVFSCETRPFLQGARLTVYELMKAGIPVTLITDNSIGSLMSRGMIDVVVVGADRIAANGDTANKIGTYMAAVLACTHGIPFYVAAPRSTIDASLPDGDGIPIEQRAPKEVTHFNGRRVAPQGAAALNAAFDVTPNKYITGIITEVGILSKPFGRAIRQALKA
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
A0LIZ1
Q8NL02
RL14_XANAC
50S ribosomal protein L14
Xanthomonas
MIQMQSYLDVADNSGAKEVMCIKVLGGSKRRYAHIGDIIKVTVKDAIPRGKVKKGEVYDAVVVRTRKGVRRPDGSLIRFDGNAAVLLNNKQEPIGTRIFGPVTRELRSEKFMKIVSLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Q8NL02
Q98DD1
DNAK_RHILO
Heat shock protein 70
Mesorhizobium
MAKVIGIDLGTTNSCIAIMDGKEPKVIENAEGARTTPSIVAISGDGERLVGQPAKRQAVTNPENTIFAVKRLIGRRYDDPVTEKDKKLVPYKIVKGDNGDAWVEAGGKKQSPSQISAMILQKMKETAEAYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKKDGKTIAVYDLGGGTFDISVLEIGDGVFEVKSTNGDTFLGGEDFDMRLVEYLAAEFKKEQGIDLKNDKLALQRLKEAAEKAKIELSSTTQTEINLPFITADATGPKHLTLKLTRAKFESLVEDLVQRTIDPCKAALKDAGLKAGEIDEVVLVGGMTRMPKIQEIVKQFFGKEPHKGVNPDEVVALGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTKKSQVFSTAEDSQSAVTIRVFQGEREMAADNKALGQFDLVGIPPAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEHQIRIQASGGLSDADIEKMVKDAEANAETDKKRRAVVEARNQAEALVHSSEKSLKEYGDKVSEAERTAISDAIAALKTAAEGDDAADIEAKSQALAEASMKLGQAMYEASQKEAAEADAKADAAKDSDVVDADFEEIDEDDDKKKSA
Acts as a chaperone.
Q98DD1
Q94AT3
PUKI_ARATH
Pseudouridine kinase
Arabidopsis
MEPVIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWKLSMKGILRREDISTPIVSLVYDTNGEVAAGVAGVDAVENFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSVPVWFEPVSVTKSQRIASIAKYVTIVSPNQDELIAMANALCAKNLFHPFRSDENKLSIEDMFRALKPAILVLLKNGVKVVIVTLGSNGALLCSKGNPKKALNIDRKFLRSGEVFKRVQSVCSPNRFSELGSNRSPSLFAMHFPTIPAKVKKLTGAGDCLVGGTVASLSDGLDLIQSLAVGIASAKAAVESDDNVPPEFKLDLISGDAELVYNGAKMLMVHQSML
Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP) . Catalyzes the first step in a pseudouridine degradation pathway . Acts together with the pseudouridine 5'-phosphate glycosidase PUMY in the peroxisome to prevent toxic pseudouridine monophosphate accumulation .
Q94AT3
A2C6Z4
ATPB_PROM3
F-ATPase subunit beta
Prochlorococcus
MAAAATATAGTKGVVRQVIGPVLDVEFPAGKLPKILNALRIDGKNPSGQHIAITAEVQQLLGDHRVRAVAMSSTDGLVRGMEALDTGSAISVPVGEATLGRIFNVLGEPVDEQGPVTTDATAPIHRPAPKLTELETKPTVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINSDDLSKSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGALQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYRTARSVQATLQRYKELQDIIAILGLDELSEDDRRTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEETIAGFNMILAGELDHLPEQAFYLVGNIDEVKAKAEKIASEAKG
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
A2C6Z4
Q5NL34
PANB1_ZYMMO
Ketopantoate hydroxymethyltransferase 1
Zymomonas
MNQHGRSAEPGVASEGIAPYGDAHRGIAAKRKKTTTARISQMRVDGEKIAVLTAYDATFAAAADAAGVDCIMVGDSLGMVCQGRTTTVGVSLEDMLYHTRCVSQGIARADGSALIIADLPFGSYQQSNEQAIASAVQLMQAGAHMVKLEGGDWWTVDIVEFLVQRGIPVCAHLRLTPQTVSALGGYRVQGRSEEAAEKLRVDAGALDNAGASMMVLEMIPTELATSITSEMKSCATIGIGAGSGTAGQVLVMHDMLGINLGRMAKFVRNFMRDAEDVPTAFAAYVAAVKDGSFPDDKLHGFL
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q5NL34
G8XHD7
BESB_STREN
L-propargylglycine synthase
Streptomyces
MSAGSPAEPRPVPGSVHSVSVSIPDVRSVIGFESGDPATLRRIAWGYPRFRTHPYVARVAALVAGAVGGRAQDLVLTRSVRAAEAAAAYAGLAPGAVFEASGVRGVRVAEDDPALAAVRGHVQHTGAHLTSREAEDVLLEAGLIEARQAEEAVSEEPAEAVRSALATAYGAGDPADVSLHNSGMNAVAAAVAAVTDLQRPAGRRRWIQLGWIFFDTMSLLDKRLFGTDHVTVPDPFDLAALSRVVAAHPGQLAGIIAELPSNPSLRCPDVPALREIADRAGCALVLDATIATPHNVDVLGYADVVCESLTKYATGSADVLMGAAVVGSASPWAAQLREGLRRFGDVPYHRDAARVAARIRDYGDRMKRVNAGAVALAGFLERQSAVRAVSWPYDAASQANYRKVERLSDAPGGLLMVDLRVPLERVYDRLAVAKGPSFGAEFTMASPQIFIAHFDLLSTPEGRAELRSRGLHRDMLRISVGVEDPELIAEVFRDAFDGAG
Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-propargylglycine (Pra) and L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes gamma-elimination of chloride from 4-chloro-allyl-L-glycine (also named L-2-amino-4-chloropent-4-enoate), followed by an isomerization, to form the terminal-alkyne product L-propargylglycine.
G8XHD7
Q47IP4
TSAD_DECAR
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Dechloromonas
MLILGVESSCDETGIALYDSEAGLLSHALYSQVAMHAEYGGVVPELASRDHIRRVVPLLREALGQAGKMLDEVDAVAYTRGPGLAGALLVGCAFAEALALAIDKPTIPVHHLEGHLLSPLLSSDPPTFPFVALLVSGGHTQLMKVTGVGEYELLGETLDDAAGEAFDKSAKLLGLPYPGGALLSKLAEQGTPGVHELPRPMLHSGDLSFSFSGLKTAVLTLVREHADAMSDEFKANAARAFQEAIVEVLVKKSLKAMKQTGLKQLVVAGGVGANKQLRTTLNDEAKRKRFRVYYPELEFCTDNGAMIALAGCLRLQSGSPSKAAGSFAVQPRWPLMEMSVSPTK
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q47IP4
Q5JIR6
RRP41_THEKO
Exosome complex component Rrp41
Thermococcus
MMGRPEGLKLIDENGKRIDGRKKYELRPIKMEVGVLKNADGSAYVEWGKNKVLAAVYGPREIHPKHLQRPDRAILRVRYNMAPFSVEERKKPGPDRRSVEISKVIRGALEPALLLHMFPRTAIDVFIEILQADAGTRVAGITAASLALADAGIPMKDLVAACAAGKIDGEIVLDLNKEEDNYGEADVPVAIMPLKNDITLLQMDGYLTKDEFLEAVRLAIKGAKAVYQKQREALKEKYLKIAQEVEGNE
Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
Q5JIR6
A2PYH4
HFM1_HUMAN
SEC63 domain-containing protein 1
Homo
MLKSNDCLFSLENLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELEEELESHKLLGQEKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDDLNLEGVGNNDLSHIAGKLTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSNDNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEAGRLMAWYYITFETVKKFYTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSEFVGLDIQQKLTVFYLEPKRFGNQITMQRKSETQISHSKHSDISTIAGPNKGTTASKKPGNRECNHLCKSKHTCGHDCCKIGVAQKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMNKSQSVDLKEFGFTPKPSLPSISRSEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVLNVNFELGNEVWDDFDDENLEVTSFSTDTEKTKISGFGNTLSSSTRGSKLPLQESKSKFQREMSNSFVSSHEMSDISLSNSAMPKFSASSMTKLPQQAGNAVIVHFQERKPQNLSPEIEKQCFTFSEKNPNSSNYKKVDFFIRNSECKKEVDFSMYHPDDEADEMKSLLGIFDGIF
Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.
A2PYH4
Q0K635
RL18_CUPNH
50S ribosomal protein L18
Cupriavidus
MMNKKDARLRRARQTRAKIAEMKVNRLTVFRTNSHIYAQVFSECGTKVLASASTAEVEVRKELDGKGATAAAATVVGKRIAEKAKAAGVETVAFDRAGFRFHGRVKALADAAREAGLKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q0K635
Q9JM93
AR6P4_MOUSE
Splicing factor SRrp37
Mus
MAHVGSRKRSRSRSRSRSGRRGSEKRSKRSSKDASRNCSASRSQGHKAGSASGVEERSKHKAQRTSRSSSTSSSSSSSSSASSSSSSDGRKKRAKHKEKKRKKKKKKRKKKLKKRVKEKAVAVHQAEALPGPSLDQWHRSAGEDNDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDGLAFQMRTGLLP
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site.
Q9JM93
A6UFK4
NUOD2_SINMW
NDH-1 subunit D 2
Sinorhizobium
MTEVTELMRPEGEALNTKEVLLNLGPQHPSTHGVLRLVLQLDGEYVERIDPHIGYLHRGTEKLAESFTYTQIFPLTDRLDYLCPPSNNLAFALAVEKLLGIEAPIRAQYIRVMMAELARISGHLLITGALPMDLGAMTALLYAMREREMIMDLLEMITGARMHTSYCRVGGVREDLPDGFLPKIREFCEIFPNRIRDYERLIENNRVFLSRTQGIGVISAADAVDLGLSGPNLRASGVDWDIRRDEPYEIYDRLDFDVITREEGDCYARWLCRVDEMRESIRLIEQCMEQMPEGPFQVDIPTIAFPVDKERVHCSMEALIQHFDLSAYGFDVPAGEVYSVIEAPKGELGFYIISDGSPKPFRMKVRAPSFVNLQALFGVTNARYLADMIAVLGSLDPVMAEVDK
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
A6UFK4
Q8Y4B8
ATPF_LISMO
F-type ATPase subunit b
Listeria
MLQPHLVIGSAFTFGDAFFTLFAFAILLVLIRIYAWKPLMGIMKEREEHIGSEIDAAEENRAQSEKLLAEQKSVLQQARVESQTMIENAKQLGEKEREEIVKTARRESERIKEEAKSDIAREKEDAISALREQVGSLSVLIASKVIEKNLDEKEQSNLIQDYIERLGDDK
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q8Y4B8
Q9LZJ7
PRP3_ARATH
Proline-rich protein 3
Arabidopsis
MAITRSSLAICLILSLVTITTADYYSPSSPPVYKSPEHKPTLPSPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKHTPSPPVYTKPTIPPPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKPTPVYTKPTIPPPVYTPPVYKPTPSPPVYKKSPSYSSPPPPYVPKPTYTPTTKPYVPEILKAVDGIILCKNGYETYPILGAKIQIVCSDPASYGKSNTEVVIYSNPTDSKGYFHLSLTSIKDLAYCRVKLYLSPVETCKNPTNVNKGLTGVPLALYGYRFYPDKNLELFSVGPFYYTGPKAAPATPKY
May contribute to cell wall structure in root hairs.
Q9LZJ7
P24181
ACRF_ECOLI
Protein EnvD
Escherichia
MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRCFKG
Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents.
P24181
Q2N9C1
RL14_ERYLH
50S ribosomal protein L14
Erythrobacter
MIQMQSNLDVADNSGAKRVQCIKVLGGSKRRTASVGDVIVVSVKEAQPRAKVKKGDVHRAVIVRTKKDVRRPDGSVIRFDSNAAVLVSKNEEPIGTRIFGPVVRELRGRGFMKIISLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Q2N9C1
Q31YT6
MSBA_SHIBS
Lipid A export ATP-binding/permease protein MsbA
Shigella
MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ
Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Q31YT6
Q8EK70
EFTU2_SHEON
Elongation factor Tu 2
Shewanella
MAKAKFERSKPHVNVGTIGHVDHGKTTLTAAISHVLAKTYGGEAKDFSQIDNAPEERERGITINTSHIEYDTPSRHYAHVDCPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVPFIIVFMNKCDMVDDAELLELVEMEVRELLSEYDFPGDDLPVIQGSALKALEGEPEWEAKILELAAALDSYIPEPERDIDKPFLMPIEDVFSISGRGTVVTGRVERGIVRVGDEVEIVGIRTTTKTTCTGVEMFRKLLDEGRAGENCGILLRGTKRDDVERGQVLSKPGSINPHTTFESEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLICPIAMDEGLRFAIREGGRTVGAGVVAKIIA
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q8EK70
A7GN77
PANC_BACCN
Pantoate-activating enzyme
Bacillus cereus group
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPLQFGPDEDFDRYPRDIKRDERVAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKRRPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGIVSDFHIPVTIVPVEIVREADGLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVDYVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
A7GN77
A3D5N8
PEPE_SHEB5
Dipeptidase E
Shewanella
MTINALLLSSSRVGDTPYLAHAIPFIKPLTTNAQKWIFIPYAGVSMSYDTYLASVVTGLSELELDISGIHQHPDPQQAIKDADGILIGGGNTFHLLHQLYRYDLVTLIGEQVALGKPYIGWSAGSNVSGLSIRTTNDMPIIEPPSFNALNLVPFQLNPHYSNYQAPGHNGETRAQRLLEFTKVDPLTPVVGIVEGSALWRQGDKLSLLGDQPAYLFCGEQQEIPIPVGSDLSHLLKA
Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
A3D5N8
A7IJG7
OIAT_XANP2
3-oxo-isoapionate-4-phosphate transcarboxylase/hydrolase
Xanthobacter
MSERVYATYWMETGGDPARTAEVIAGEQSSGTFVALATETAELKERSGARVERLDILDTADIPSLPGGMASDRYTRAILELSWPVENFGPSLPNLMSTIAGNLFELHQVSGLRLIDLKLPPSFTNAFAGPAFGIAGTRKLAGVAQGPIIGTIIKPSIGLTPEETAQQVRELIAGDIDFIKDDELQADGARCPFEARVKAVMRVVNDAADRRGRKVMVAFNITGDLDEMRRRHDLVLAEGGTCVMVCLNSIGLVGVREIRRHTQLPIHGHRAGWGYLYRCPSLGWDYAPWQQLWRLAGVDHLHVNGLDNKFSEANASVIAAARAVLSPLNHAAPMGAMPVFSSGQTGRQAAETYAAIGCADLIHTAGGGIFGHPAGVPAGVEALRAAWRAAMAGASLEDEATRSPALRSALGFWR
Involved in catabolism of D-apiose. Catalyzes the conversion of 3-oxo-isoapionate 4-phosphate to 3-phosphoglycerate and glycolate.
A7IJG7
P07128
KHSE_CORGL
Homoserine kinase
Corynebacterium
MAIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVVKAIRAGLKAADAEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRATALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYRAEVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAGPVKVEVNQP
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
P07128
P27477
THTR_SYNE7
Rhodanese-like protein
Synechococcus
MSVRSLRWPRQKAFLAVISLVVAVLLAVPGWLTPATAASQATVQFVAPTWAAERLNNKQLKILDVRTNPLAYIEGHLPGAVNIADAAYRGPNGFLPVQIWDPEKLASLFGRAGVSNNDTVLVYSDGNDVLGATLVAYLLERSGVQNIAVLDGGYKGYKDAGLPVTKEYPRYQAARFAPKDNRAFRVDIKQVEQLTGKSTFVDPRPPALFSGEQQVFIRNGHIPGARNIPWPTFTEANNANESLKNPHKLKPLSELKAILEAKGVTPDKDVIVTCSTGREASLQYLVLKHLLKYPKVRIYEGSWTEYSASNLPVETGPDRV
May be a sulfotransferase involved in the transport of sulfate. Displays very low rhodanese activity.
P27477
B9DX62
ATPG_CLOK1
F-ATPase gamma subunit
Clostridium
MAGAGLVTIKRRIKSITSTQKITKAMGLIATSKLRKVRKKLEANNKYCELFSSIVNELAMEAEQNNIYIKGNKSNKKLYIALNSDTGLCGGFNANVVNELNSIRSKEKEDFLLITMGQKGKMYFRRLNYNIESEYIDIPDVPTIKETEDVVYKALELYRNGEIGEINIVFTKFISTIKQNVIVEKLLPLEVKKVEKRNFIVKFEPSADEMIEDIVELHLRQKLLNCIINSKVSEQSSRMTAMDGATKNANDLLDELNLQYNRERQTAITQEITEIVGGAEALK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
B9DX62
B1KFT2
RPIA_SHEWM
Phosphoriboisomerase A
Shewanella
MTQDEMKKAAGWAALEYVEKDSIVGVGTGSTVNHFIDALATMKAEIEGAVSSSEASTQKMKDLGIPVFDLNSVDELSVYVDGADEINAHMDMIKGGGAALTREKIVAAVADKFICIVDNTKQVDVLGEFPLPVEVIPMARSYVARQLVKLGGDPVYREGVITDNGNIILDVYNMKIVNPKELEQQINKIVGVVTNGLFANRGADVLLVGSPDGVKTLK
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
B1KFT2
O57762
THS_PYRHO
Chaperonin subunit
Pyrococcus
MAQLAGQPILILPEGTQRYVGRDAQRMNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVITNDGATILDEMDIQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLKKAEELLDQNIHPSIIIKGYTLASQKAQEILDSIAKEVKPDDEEVLLKAAMTAITGKAAEEEREYLAKLAVEAVKLVAEEKDGKLKVDIDNIKLEKKEGGAVRDTRLIRGVVIDKEVVHPGMPKRIENAKIALINDALEVKETETDAEIRITSPEQLQAFLEQEEKMLKEMVDKIKEVGANVVFVQKGIDDLAQHYLAKYGILAVRRVKKSDMEKLAKATGAKIVTNIRDLTPEDLGEAELVEERKVAGENMIFVEGCKNPKAVTILIRGGTEHVVDEVERALEDAIKVVKDILEDGKIIAGGGASEIELSIKLDEYAKEVGGKEQLAIEAFAEALKVIPRTLAENAGLDPIETLVKVIAAHKEKGQTIGIDVYEGEPADMMERGVIEPVRVKKQAIKSASEAAIMILRIDDVIAASKLEKEKEGEKGGGSEEFSGSSDLD
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
O57762
C5BPQ5
CCA_TERTT
Phosphatase
Teredinibacter
MKIYLVGGAVRDQLLGYPHHEQDWVVVGATPQQMLDAGFKPVGKDFPVFLHPETQEEYALARQERKTAPGYTGFAFHADETVTLEQDLLRRDLTINAIAMDEEGTIIDPYNGKRDIETRTLRHVSQAFCEDPVRILRIARFAARYHHLGFRIAPETLALMRDMVQAGEVDHLVAERVWKELSRALEEQHPAIFIQTLRECGALHRLMPELNALFGIPQPEAHHPEVDTGVHALLALERACELSSTPEVRFAALIHDLGKGVTPKHLWPSHHGHEQDGVALVEQLCNRLSTPNQFRELAVAVCAYHTHCHRAFELNAKTLLKTLLALDGLRRPERFQQFCLCCQADAQGRTGLENRPYPQAAYFLQALEEIQKVDAKMFVAQGKKGAEIGEAMYSARLQKIKLLKTAQTPHE
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
C5BPQ5
B2S928
G6PI_BRUA1
Phosphohexose isomerase
Brucella
MARDATKLEATVAKLKKHWAESAPRDMRAAFSTDPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDEPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRKA
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
B2S928
A5CEN6
IF2_ORITB
Translation initiation factor IF-2
Orientia
MTDKHNEEGKEKKLKLPSKMIIGKHVDSKKFKTSYFTSHNNSVTVEIKGGRKFSSSSSLPHKINTQISTIDEFNEKISLLKKAASFAKSEEYRSNVTNFSSTVEVTEQQTEAENSTNINLSEQTIKNNSHQSSSNTIETTQEKKQNDDLSSNITPVEAITQLEPNQKILQNQQNSSSISLNSIISKPQNKSSIENNVEFETEATSTKSSAIWTKKNNSAKPKKSDIYQMLDSDSKSKTRSFAAIKRARDKEKRKLQNNALTKKIYREVIIPDTITVNELALRMSEKLSDVMQALLKLGIKANINQSIDVDTAELIAISLGHSVKRTQDSDVENILHSDKDTQDSLLPRAPIITVMGHVDHGKTCLLDALRSTDVISTEAGGITQHIGAYKVNLPNNKSITFIDTPGHEAFSEIRTRGAKVTDIVVLVIAANDGIKPQTIEAINHAKAAKVPILVAINKIDAPDANPDKVKNALLAHNIVPEDLGGETLVVPISALKKINLDKLEEAILLLADMLELKANPNALASGTVIESQVDHKSGVIATILVQRGTLKIGDILIAGNGFGKVKRMINDKNQQVNYAYPSDPVKILGLSQIPNAGDAVAVVQNEKQARSIVDYRIRKAKEEQDLKVHNISLEELLKQASANQFKELSLILKTDVHGSLEAIVASINKIVNDEVKIKILHAAVGVINESDIILANASNATILGFNVKIDSTASIKAERNKTNIKYYSIIYDLIDYVKSAVSGMLSPIIHEEYTGRAEVRAVFNITKVGKIAGCYVTKGYIQRNSKVKLLRNNEVIFSGPLQTLKRFKEHTKEVKEGFECGIELANYYDINVGDIIEAFIVTEEKAKL
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A5CEN6
Q7U571
PSAJ_PARMW
Photosystem I reaction center subunit IX
Parasynechococcus marenigrum
MQKFLTTAPVVAAIWFTLTAGILIEWNRFFPDLLFHPM
May help in the organization of the PsaE and PsaF subunits.
Q7U571
B5Z6T1
ACP_HELPG
Acyl carrier protein
Helicobacter
MALFEDIQAVIAEQLNVDAAQVTPEAEFVKDLGADSLDVVELIMALEEKFGVEIPDEQAEKIVNVGDVVKYIEDNKLA
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
B5Z6T1
A1RDZ0
AROE_SHESW
Shikimate dehydrogenase (NADP(+))
Shewanella
MTDKYAVFGNPISHSKSPFIHGQFAAPTQELLTYEAILAPVDGFEASLTAFFNAGGKGANVTVPFKEQAFALCDSLSPEAKLAGAVNTLSLLADGTIRGDNTDGLGLVADLIANLGSLQGKRVLLIGAGGAARGCILPLLNAGIAQLTISNRTHTKAQLLVDIFTSVDNGAFANRVTAVEMNELVGEFDIIINSTSASLAGELPPVPAHIITPQTVCYDMMYGASVTAFNQWALSQGAAKVIDGLGMLVGQAAKSFTLWRGVEPDTQVVLTLLRDKLKAEPK
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
A1RDZ0
A7ZP75
ARNT_ECO24
Undecaprenyl phosphate-alpha-L-Ara4N transferase
Escherichia
MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTTALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPDFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYRPK
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
A7ZP75
A1WY18
QUEC_HALHL
Queuosine biosynthesis protein QueC
Halorhodospira
MAERPQRVPASTEQESALVLFSGGQDSTACLAWALEYFSRVETVGFAYGQRHDVELSAREEVLDGLRALRPDWAARLGSDRVLDAGVLGEISDTALTQDAEIAYDARGLPTTFVPGRNLLFFTLAAAVAHRRGIRHLVAGVCETDFSGYPDCRDDTVKSLQVTLNLGMAERLVLHTPLMWLDKAQTWMLAEQLGGSALVDLTVEASHTCYYGMREQRHEWGYGCGECPACRLRAEGWHRFRHGSGAQ
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
A1WY18
Q14FE6
YCF4_POPAL
Photosystem I assembly protein Ycf4
Populus
MSWRSEHIWIELIAGSRKISNFCWAIILFLGSLGFLLIGISSYLDRNLISLFPSQQIIFFPQGLVMSFYGLAGLFISSYLWCTISWNVGSGYDRFDRKEGIVCIFRWGFPGKNRRILLRLFMKDIQSIRIEVKEGFYARRVLYMEIRGQGAIPLTRTDENLTPREIEQKAAELAYFLRVPIEVF
Seems to be required for the assembly of the photosystem I complex.
Q14FE6
Q32BA8
RL13_SHIDS
50S ribosomal protein L13
Shigella
MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMSRKLKVYAGNEHNHAAQQPQVLDI
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q32BA8
P56689
DPOL_THEGO
TO POL
Thermococcus
MILDTDYITEDGKPVIRIFKKENGEFKIDYDRNFEPYIYALLKDDSAIEDVKKITAERHGTTVRVVRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIKEHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKNIDLPYVDVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGREGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWETGEGLERVARYSMEDAKVTYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDERELARRRESYAGGYVKEPERGLWENIVYLDFRSLYPSIIITHNVSPDTLNREGCEEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKVKKKMKATIDPIEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIETTIREIEEKFGFKVLYADTDGFFATIPGADAETVKKKAKEFLDYINAKLPGLLELEYEGFYKRGFFVTKKKYAVIDEEDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIYEQITRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLGAWLKPKT
In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.
P56689
D2Y234
H4B01_CYRHA
Hainantoxin-IV-2
Haplopelma
MKASMFLALAGLALLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRRCKYEIGK
Neurotoxin. Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav). Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels.
D2Y234
P32961
NRL1_ARATH
Nitrilase 1
Arabidopsis
MSSTKDMSTVQNATPFNGVAPSTTVRVTIVQSSTVYNDTPATIDKAEKYIVEAASKGAELVLFPEGFIGGYPRGFRFGLAVGVHNEEGRDEFRKYHASAIHVPGPEVARLADVARKNHVYLVMGAIEKEGYTLYCTVLFFSPQGQFLGKHRKLMPTSLERCIWGQGDGSTIPVYDTPIGKLGAAICWENRMPLYRTALYAKGIELYCAPTADGSKEWQSSMLHIAIEGGCFVLSACQFCQRKHFPDHPDYLFTDWYDDKEHDSIVSQGGSVIISPLGQVLAGPNFESEGLVTADIDLGDIARAKLYFDSVGHYSRPDVLHLTVNEHPRKSVTFVTKVEKAEDDSNK
Can convert indole-3-acetonitrile to the plant hormone indole-3-acetic acid.
P32961
Q92A81
AROB_LISIN
3-dehydroquinate synthase
Listeria
MPEITVRAKSKTYPVYINEFALTDVKEQWTKSLAKYSHVFVLTDEHVANLHKAKLDAVLADLPVVTYYVAPNGEEAKTFRVYEDVMTKMIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRSGFAEMIKHALISDHALLTALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVRAYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETVYGLDFDLAKFTTWLERLGYNTTFDVTVPFSNILDNMRHDKKTTFNEISMVLLEDIGKPVIFKAEDELIFDTYKSVMRNGGDLF
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Q92A81
Q7L5N1
CSN6_HUMAN
Vpr-interacting protein
Homo
MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.
Q7L5N1