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2.75k
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5.51k
AlphaFoldDB
stringlengths
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10
B6J7H5
MNMA_COXB1
tRNA-specific 2-thiouridylase MnmA
Coxiella
MGIIFYTTQMPNFEQNQVIAVGLSGGVDSSVAALVLKEKGYEVIGLFMQNWETDSKDPFCTAEQDLSDAKAIADHIGIPLYVVNFSKAYWNHVFQHCLDEFAQGRTPNPDVWCNREIKFKSLLDHAKKLGATHLATGHYACIQNENNEYRLLKSNDSHKDQSYFLHLLNQYQLANSVFPIGGYQKSEVRAIAKKRGFINHAKKDSTGICFIGERKFKDFLNEFLLAQPGNIETPEGKIIGKHDGIMFYTVGQRKGLHIGGRPDAGEAPWYVVDKDVKRNVLIVVQGYEHPLLYSQELTCTNLHWIRDTEPSFPLTCKAKTRCRQADQTCVITRLDNDHCHVQFEHPQRAITRGQSVVFYLGNECLGGGIIN
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
B6J7H5
A2WTA0
PLA3_ORYSI
Phospholipase A1-II 3
Oryza sativa
MCCFLLVSVLLATTLTDVASAQRWRQTSGGGKDRWDGLLDPLDADLRRDIIRYGELAQATSDALIGDPASPFAGASRYAPDAFLRKVRASDPDAYRVTRFVYATSSVRLPDAFMPRPAPSAGAAWSGESNWMGYVAVAADGVAANAGRRDIVVAWRGTKRAVEWANDLDITLVPADGVVGPGPGWTQPSVHRGFLSVYTSKSFSSPFNKLSAREQVLAEITRLLRAYKNENCSITITGHSLGAALSTLNAIDIVANGYNVRGSSRVPVPVTAIALASPRVGDDQFKRAFDSTPNLSLLRVRNAPDIVPTILPSAFFKDVGAELLVDTRRSPYLKNPAGPAQWHNLECYLHAVAGTQGAGDGAGFSLVVDRDLALVNKEVDALRDEYQVPAAWWVEKNKGMVQNASGRWVLQDHEEGNLAM
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
A2WTA0
Q2IFT9
RSMA_ANADE
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Anaeromyxobacter
MTDRYPSPRALLDRYDLRAKKSWGQNFLGEEAVLDDIARLAAPRAGDPVLELGAGLGHLTARLLARGARVVAVERDRDMARVLRGELGDRITLLEADAARLDHAALAARFGAPAAAGEGARLAVVGNLPYHLTSPILFSILDQVAHVSRAVFLLQREVAERLAAPPASRDWGLLSVLLQREAEVSVERIVPPGAFWPPPKVESAVLCALFRPPADAVGDPARFRRLVKAGFGLRRKTLRNALGSAKLAEPARLEAAFAAAGVDPGRRGETLTLAEWAALDRALG
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q2IFT9
B8F6C8
AROQ_GLAP5
Type II DHQase
Glaesserella
MKKILLLNGPNLNMLGKREPHIYGSQTLADIENHLQQLAKARGYCLEYFQANGEEPIINRIHQSFQNTDFIIINPGASTHTSVALRDALLSVAIPFVEVHLSNVHAREPFRHHSYLSDVAKGVICGLGAKGYDYALDYAIQFLKSGK
Catalyzes a trans-dehydration via an enolate intermediate.
B8F6C8
Q0AJB4
ATPF_NITEC
F-type ATPase subunit b
Nitrosomonas
MNINFTLVSQAIAFSIFIWFTTKFVWPYLLRAIEERQQKIADGLAAGERGKKELELASQRSSEVLKEAKQRAGEIVIQAEKRASDIIEEAKKNARVEGEKILAGAKAEIQHEIFSARESLRQQVAGLAVQGASKILRREVNAKAHADLLASIETELK
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q0AJB4
Q92ME7
AROB_RHIME
3-dehydroquinate synthase
Sinorhizobium
MTSHVMPTAERKVRVDLAERSYDILIGPGLIAAAGKEIASRLKGRKMAVITDENVAPRYLEPLMASLGESGIEAVSLILPAGEKTKSFEHLIPVCEAILGARIERNDAVIALGGGVIGDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINSAHGKNLIGVFHQPDLVLADTAALDTLSPREFRAGYAEVAKYGLIDKPEFFEWLEKNWQAVFAGGPARIEAIAVSCQAKADVVAADERENGRRALLNLGHTFGHALEAATDYDSKRLVHGEGVAIGMVLAHEFSARMNLASPDDARRVEAHLKTVGLPTRLADIPGALPPADRLMEAIAQDKKVKGGKLTFILTRGIGQSFVADDVPSSEVLSFLTEKHPR
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Q92ME7
Q73U04
Y3564_MYCPA
Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_3564
Mycobacterium avium complex (MAC)
MSSLRTHDDTWDIKSSVGTTAVMVAAARAVETEQPDPLIRDPYAKLLVTNSGAGVLWEAMLDPDIAARVEALDEESAAHLHHMRGYQAVRTHFFDTYFADAVAAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSTTLAENGVTPSADRREVAVDLRQDWPAALRAAGFDPTQRTAWLAEGLLMYLPAEAQDRLFTLIGELSPAGSRVAAETAPNHADERRQQMRERFKKVADEIGFEQTVDVGELMYRDDHRADVTEWLNAHGWRATAEHSTAAMRRLGRWIENVPLADDKDAFSDFVVAERR
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Q73U04
Q0ID12
RL16_SYNS3
50S ribosomal protein L16
unclassified Synechococcus
MLSPKRVKFRKQQRGRMRGVATRGNTIAFGQFALQAQECGWITSRQIEASRRAMTRYVKRGGKIWIRIFPDKPVTMRPAETRMGSGKGNPEFWVAVIKPGRILFEMGGEEITPEIAKEAMRLAQYKLPLKTKFICLDEQEQPAGTKAAASSTVES
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q0ID12
Q2NF86
VATF_METST
V-ATPase subunit F
Methanosphaera
MKNDIAIMADPDTVTGFMLGGIKSGFPVHNKEEAKTTLKQLVDDEYSIIITTEKIGDELRDDITKYTGSKALPMIIEVPDKSGSHKRETDPMNDLIKRVIGVEMVK
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q2NF86
Q8GYX8
DNJ10_ARATH
Chaperone protein dnaJ 10
Arabidopsis
MVKETEYYDVLGVSPTATESEIKKAYYIKARQVHPDKNPNDPQAAHNFQVLGEAYQVLSDSGQRQAYDACGKSGISTDAIIDPAAIFAMLFGSELFEGYIGQLAMASMASLDIFTEGDQFDTKKIQEKLRIVQKEREDKLAQILKDRLNEYVINKDEFISNAEAEVARLSNAAYGVDMLNTIGYIYVRQAAKELGKKAIYLGVPFIAEWFRNKGHFIKSQLTAATGAYALFQLQEEMKRQLNTEGNYTEEELEEYLQAHKRVMIDSLWKLNVADIEATLCRVCQLVLQDPEAKREELRTRARGLKALGRIFQRAKTASESDPLENSEPQKLNGNGKNHDEDTSTSPKSSEASHSTSGPQEPQSPYVEEFKLGDEQFNYYFPRPAPPPGAGKYSSSGYD
Plays a continuous role in plant development probably in the structural organization of compartments.
Q8GYX8
Q765Z5
EDN2_RABIT
Preproendothelin-2
Oryctolagus
MVSVPTAWCSVALALLVALHEGKDQAAATLEQPASSPRARAAHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRRRRSLPGRCECSSARDPACATFCHQRSRADAVGVPGSQSSADAFQAGKTWATPGELLRTLRDISAAKTHFAKRQQEATREPRTTHSRHRKR
Endothelins are endothelium-derived vasoconstrictor peptides.
Q765Z5
Q661C7
RL6_BORGP
50S ribosomal protein L6
Borreliella
MSRIGRLPIKIPDTVKIDVKGNLVIVEGTRGKLVQDIKDSINVKVENGSVIVNRAFNDKKTKAYHGLYRSLIFNMVKGVTEGFSKSLTINGIGYRVEQQGNSLFLNLGYSTQFEYVVPDGVSVKLDGNTKISVEGIDKFKVGQVAAEIRSLKKPEPYKGKGIKYDNEVIRRKVGKSGVKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q661C7
A5UCB7
NUSB_HAEIE
Antitermination factor NusB
Haemophilus
MTEQKQVKKPSARRRARECTVQALYSWAVSGNTAEQVELAFVLDQDMDGVDKPYFRKLFRQTIENIETVDFSISPYIDRTFDELDPIETAILRLAVYELRFELDVPYKVVINEAIEVAKVFGADESHKYINGVLDKIAPALGRK
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
A5UCB7
Q6B903
CYB6_GRATL
Cytochrome b6
Agarophyton tenuistipitatum
MGKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCIGGIVFTSFLIQVASGFAMTFYYRPTVAEAFSSVEYIMTDVNFGWLIRSIHRWSASMMVLMLILHMFRVYLTGGFKKPRELTWVTGVILAVLTVSFGVTGYSLPWDQIGYWAVKIVTGVPEAIPVVGGSIVELLRGGVSVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Q6B903
Q73YS2
PYRD_MYCPA
Dihydroorotate oxidase
Mycobacterium avium complex (MAC)
MSGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTDPVLASTVFGVRFPGPLGLAAGFDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFRLPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGKTKATPPDQAVDDYRASARLLGPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIADLAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADHAWERITAGASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRDAVGSSARESG
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Q73YS2
Q90YW1
RL8_ICTPU
60S ribosomal protein L8
Ictalurus
MGRVIRAQRKGAGSVFKAHVKHRKGAAKLRHIDFAERHGYIKGIVKDIIHDPGRGTPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVFCGKKAQLNIGNVLPVGVMPEGTIICCLEEKPGDRGKLARASGNYATVISHNPETKKSRVKLPSGAKKVISSTNRAVVGVVAGGGRIDKPILKAGRAYHKYKVKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDVPAGRKVGLIAARRTGRLRGTKTVQEKEN
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Q90YW1
Q63E02
DLTA_BACCZ
D-alanine-activating enzyme
Bacillus cereus group
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTSTPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFMYQSSIPMTPNGKVDRKKLLSEVTA
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
Q63E02
B8CHZ1
RHLB_SHEPW
ATP-dependent RNA helicase RhlB
Shewanella
MSETHLSTKKFADFPLHKEVQQALNEVGFEFCTPIQALSLPILLAKKDIAGQAQTGTGKTLAFLVATFNHLLTEAAPTERKINQPRAIIMAPTRELAIQIAKDANLLAKHTGLKVGIVYGGEGYEAQRKVLDKGIDILIGTTGRIIDYVRQGVIDVSAIQAVVLDEADRMFDLGFIKDIRFLFRRMPDAKSRLNMLFSATLSMKVQELAYDHMNEPEKVEIAPNEKTSKNIKEEIFYPSMEEKMPLLLSLLEEDWPEKAIVFSNTKHSCEKVWSWLEGDGHRVGLLTGDVPQKKRLRILEQFTSGDIDVLVATDVAARGLHIADVSHVYNYDLPDDCEDYVHRIGRTGRAGQKGVSVSFACEEYALNLPAIESYIQHSIPVTSYDSEALLDDIPAPKRIHRKPSSHSRNSRDRSGSRPQGGHRGNAPRRHDKTRRHS
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
B8CHZ1
B8ZLY7
HRCA_STRPJ
Heat-inducible transcription repressor HrcA
Streptococcus
MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVNLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYRYLSSNHYEVH
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
B8ZLY7
B7K765
TSAD_GLOC7
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Gloeothece citriformis
MATILSIETSCDETAVAIVKNRNIYSNIVASQIDLHQTYGGVVPEVASRQHLETINPCLEQAFIEANLNWSDIDGIAATVAPGLIGALMVGVSAAKTLSILYQKPFIGVHHLEGHIYASYLSEPDLQPPFLCLLVSGGHTSLIYVKDCGIYEMLGSTRDDAAGEAFDKVARLLQLSYPGGPIIDRMAQTGNPHAFSLPEGRVSLPEGGYHPYDSSFSGLKTAVLRLVQKLEQDHLSLPVHDLAASFQETVARSLTKKTITCALDYNLTTIAVGGGVGANSALRKHLTSAATEHNLKVFFPPLKLCTDNAAMIGCAAADHFNRGHFSPLSIGVQSRLPITEVMKLYQ
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
B7K765
B8DBH8
ATPD_LISMH
F-type ATPase subunit delta
Listeria
MSKDLEVAGRYANALFQVAQDKDLVDVFSEELTELKAALNANKDFVKLLENPTFTTEQKKNLASAVFEKINPTLRDFIYLLIDRSREDYLSVIADVYQKRVNDLNGVADADVYSVVPLSEQELTALSRVFAAKMNKTKLNIQNHIDKSLLGGVKVVIGTRIYDDSLKTKLKDMERQIKA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
B8DBH8
Q3AV44
PNP_SYNS9
Polynucleotide phosphorylase
unclassified Synechococcus
MQGKTQSISFDGREIRLTTGRFAPQAGGSVLVECGDTAVLVTATRSKGRDGIDFLPLICDYEERLYAAGRIPGSYMRREARPPERATLTCRLIDRPMRPLFPSWMRDDLQVVATCLSLDERVPSDVLAVTGASIATLLAGIPFNGPMAAVRVGLLGDDFVLNPSYREIERGDLDLVVAGTADGVVMVEAGANQLPEGDVIEAIDFGYEAIQELIKAQETLLKDLGIKQVKPEAPKEDTTVPAYLEKQCTKAISAVLSKFEQSKEDRDNGLEAVKADAAEAIAALKEDDAVRQAVSSSSKLLGNSFKALTKKLMRQQILKDGKRVDGRGLDEVRQISAMAGVLPRRVHGSGLFQRGLTQVLSTATLGTPSDAQEMDDLHPNTEKLYLHHYNFPPYSVGETRPMRSPGRREIGHGALAERAILPVLPEKDTFPYVVRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLIKEGKDIKILTDIQGIEDFLGDMDFKVAGSEKGITALQMDMKITGLPVKVMAEAVNQARPARLHILEKMLEAIDKPRETLSPHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDSGIVTIASHDGAAAEEAQKIIEGLTRKVNEGEMFSGSITRIIPIGAFVEILPGKEGMIHISQLSEARVEKVEDVVKVGDEVTVRVREIDNRGRINLTLRGVPQSGESTEVEPQPTPVAPLS
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q3AV44
A0QSG2
RS14Z_MYCS2
30S ribosomal protein S14 type Z
Mycolicibacterium
MAKKALVHKANKKPKFAVRAYTRCNKCGRPHSVYRKFGLCRICLREMAHAGELPGVQKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
A0QSG2
Q49WZ1
KGUA_STAS1
GMP kinase
Staphylococcus
MDNEKGLLIVLSGPSGVGKGTVRKKIFDDPSTSYKYSISMTTRDKRQGEVDGVDYFFKAKSEFEELIKQDQFIEYAEYVGNYYGTPVQYVKDTMDRGYDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDHLRERLVGRGTESSEKIQSRVHEARKEVEMMNLYDYVVVNDEVELAKQRIQSIVEAEHLKRERIEAKYRKMILEAKK
Essential for recycling GMP and indirectly, cGMP.
Q49WZ1
Q4GWV4
DEFCG_CRAGI
Mantle defensin
Crassostrea
MKVFVLLTLAVLLMVSADMAFAGFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK
Antibacterial peptide mostly active against Gram-positive bacteria (M.lysodeikticus, S.aureus, and the marine bacteria, B.stationis, and M.maritypicum) . It acts by selectively inhibiting peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis . It does not disrupt cell membranes . Is noticeably more potent than Cg-Defh1 . It shows no or limited activities against Gram-negative bacteria and filamentous fungi .
Q4GWV4
Q92S27
MURA_RHIME
UDP-N-acetylglucosamine enolpyruvyl transferase
Sinorhizobium
MDRIRIVGGNELHGVIPISGAKNAALPLMIASLLTDDTLTLENVPHLADVEQLIRILGNHGADISVNGRRERQGESYARTVHFTSRNIVSTTAPYELVSKMRASFWVIGPLLAREGKARVSLPGGCAIGTRPVDLFIEGLAALGANIEIDGGYVNATAPAGGLIGARYVFPKVSVGATHVLMMAATLANGTTVLGNAAREPEVVDLAKCLNAMGAKISGQGTSTVTIEGVRSLSGARHRVLPDRIETGTYAMAVAMAGGDVILEDTEASLLDTALEAIRRAGAQISETNSGIRIVRNGAGIKPVDIVTDPFPGFPTDLQAQFMGLMTRSSGVSHITETIFENRFMHVQELARLGAKISLSGQTAKVEGVSRLKGAPVMATDLRASVSLVIAGLAAEGETMVSRVYHLDRGFERLEEKLTRCGAHVERVSD
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Q92S27
Q60848
HELLS_MOUSE
Proliferation-associated SNF2-like protein
Mus
MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRPIKGKTGIFKILENSEDSSAECLF
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
Q60848
B2TIH7
RL23_CLOBB
50S ribosomal protein L23
Clostridium
MKLTSHDIIRKPVITEKSMAAMAEKKYTFMVHVNANKSQVKRAVEEVFDVKVKDVNTINGLGKTKRMGVHVGKRSDYKKAIVTLTEESKAIEFFDGLQ
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
B2TIH7
B1I4W9
RNPH_DESAP
tRNA nucleotidyltransferase
Candidatus Desulforudis
MIRVDGRAPAQMRPVYITRHYNKYAEGSALIEVGDTRVICTASIDNRVPTFLKGAGKGWVTAEFGMLPRATGVRGIRESVKGHPGGRSLEIQRLIGRSLRAVVDLPALGERTVILDCDVIQADGGTRTAAITGGFVALVDAMQTLVTEGVTPRLPVLDYVAATSVGLFEGEAVLDLCFAEDSAAEVDFNVVMTGTGRFVEVQGTGEGTTFERADVDRLLDLAVVGIRSLVEQQRAVLGSLAEEIGKRRGNQNGAAGTGDQK
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
B1I4W9
Q1BRW0
RL5_BURCA
50S ribosomal protein L5
Burkholderia cepacia complex
MARFQEFYKEKVVPGLIEKFGYKSVMEVPRITKITLNMGLGEAIADKKIIENAVGDLTKIAGQKPVVTKARKAIAGFKIRQGYPIGAMVTLRGQAMYEFLDRFVTVALPRVRDFRGVSGRAFDGRGNYNIGVKEQIIFPEIDYDKIDALRGLNISITTTAKTDDEAKALLASFKFPFRN
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Q1BRW0
B8DNL3
TIG_DESVM
PPIase
Desulfovibrio
MEYTVEDLSPVKKKVNISVPVEEVEAALSAAIAMYRTNMSLDGFRKGKVPSNLVESRFRKEIYGEATQDLVNVHINEVMTALDANPISRIDFDGGQLERGTPFEYSISFEVLPEFDLPDYDGFAVEQEKAVVDMKEVDEVITRIRTNMAELVPVAEARPGKDGDVVVLDFAAFENGEPVEGISAENFQMNLGDRQALEDFENLVKTLAPGQEGEGPLNFPADFINPDFAGKSLTVKVKVHAVKERRLPEANDELAQKAGGFESMDKMREAVTSSYMQSRTQLVKATAQKTMLDKLLKMVDFPLPESMVDMYVGHLLDDMRSKLERQGKSMESLGKKPEELRAEVRPEAEQVTRTQIFLLRAARKEGVEVNEQEIDGQIQQIAMRSGQDYNALKDYYIKNNLIFSLRDRMLADKAMDAIYEKAAVTEVEPAAK
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
B8DNL3
Q28642
BKRB2_RABIT
B2 bradykinin receptor
Oryctolagus
MLNITSQVLAPALNGSVSQSSGCPNTEWSGWLNVIQAPFLWVLFVLATLENLFVLSVFCLHKSSCTVAEVYLGNLAAADLILACGLPFWAVTIANHFDWLFGEALCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSIGRMRRVRWAKLYSLVIWGCTLLLSSPMLVFRTMKDYRDEGYNVTACIIDYPSRSWEVFTNVLLNLVGFLLPLSVITFCTVQILQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQVSTFLDTLLKLGVLSSCWDEHVIDVITQVGSFMGYSNSCLNPLVYVIVGKRFRKKSREVYRAACPKAGCVLEPVQAESSMGTLRTSISVERQIHKLPEWTRSSQ
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Q28642
Q2JV83
RL23_SYNJA
50S ribosomal protein L23
unclassified Synechococcus
MTESKRILADVLLRPVITEKATALMEQRKYVFEVMPTATKPLIRAAVEEMFGVRVTAVNTLKLPRKQRRVGRSVGYRSRPKRAIVTLAEGDSITLFPDT
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Q2JV83
P70445
4EBP2_MOUSE
Phosphorylated heat- and acid-stable protein regulated by insulin 2
Mus
MSASAGGSHQPSQSRAIPTRTVAISDAAQLPQDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGALIEDSKVEVNNLNNLNNHDRKHAVGDEAQFEMDI
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation . Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways .
P70445
B4T769
MDH_SALNS
Malate dehydrogenase
Salmonella
MKVAVLGAAGGIGQALALLLKNQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQIAKTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKRPTEVEVPVIGGHSGVTILPLLSQIPGVSFTEQEAAELTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQHSLDAMLDTLKKDIQLGEDFINK
Catalyzes the reversible oxidation of malate to oxaloacetate.
B4T769
P77888
PYRF_LACPL
OMP decarboxylase
Lactiplantibacillus
MKRPIIIALDFPTAERALAFLDQFPADLHVTVKIGMELFYAAGPSIVTDVQARGHAVFLDLKLHDIPNTVESAMRVIGRLGVTYTTVHAAGGHVMLSAAKRGLVAGAMAAGVTAPKLLAITQLTSTNQAILNQDQQIMGTVRASVVHYAKLARASDCDGVICSAQEVQAIHTAVGADFLGITPGIRPASAQSDDQQRVMTPAAAAKAGSNGLVIGRPITQAAEPVQAYRDIMTEWSN
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
P77888
Q46F67
CRCB1_METBF
Putative fluoride ion transporter CrcB 1
Methanosarcina
MGKLFLIGAGGFIGACLRYTVSSQVPRIKNIPAGTLTVNLLGTIVLAFLTFSSEPQSMVYLVNIGILGSFTTFSTFAYETFKLLEEGQNFSFFLNIFLNVALCLVGVSIAYLALSL
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q46F67
Q2SFY4
CHEB2_HAHCH
Protein-glutamate methylesterase/protein-glutamine glutaminase 2
Hahella
MNAKIKVLLVDDSAVVRQVLQQVLERDKNIEVIGAAADPIFAQLRMSKQWPDVIVLDVEMPRMDGITFLKKLMAERPTPVVMCSTLTSKGAQTSMKALAAGAVAVVAKPAVGVKEYLESAAGELIMEIKAAAKANMRNMPAATASAQSMALPAKFSADAVIPLRTGGVIAGANKIAALGTSTGGTQALEYVLTRLPRNCPGIVIVQHMPEKFTAAFAERLNSICELEILEAESGHQVAPGRALIAPGGKHMLLRRSGAQYFVEIMSGPPVNRHRPSVDVLFRSVAQAAGRNALGVIMTGMGDDGAKGLLEMRNAGALTIGQDERSCIVYGMPKEAAKIGAVTREISLERIPQCVLDMGASLTASAQRG
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q2SFY4
Q89MU0
RSMA_BRADU
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Bradyrhizobium
MSAIDDLPPLREVIRQHALSARKSLGQNFLLDLNLTARIARAAAPLDNSTIVEIGPGPGGLTRALLALGARRVVAIEHDERAIPALQDISARYPGRLEIVHGDAMTFDPRPLLNGESAKIVANLPYNIATQLLINWLTTEPWPPWYDMMVLMFQREVGERIVAREDEEAYGRLGVLANWRCETKILFDIAPSAFVPPPKVTSSVVRLVPRAEPLPCDRKMLEQVAAAAFGQRRKMLRQSLKSLGVDPARLAQAAGVDATRRAETIPISGFVAMARELADIRSEG
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q89MU0
B4HNS1
TRE12_DROSE
Facilitated trehalose transporter Tret1-2 homolog
Sophophora
MKILMRADTHVSYSVPAEGTKANFTFSQVLAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVCYVAGSFMNWSILAFLGAALPVPFLILMIIIPETPRWFVNRGQEERARKALKWLRGKEADVEPELKDLMQSQAEADSQATRNTCLELFKRINLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLCTIIVGIVNFFATFMGIILIDRLGRKILLYVSDIAMILTLSILGGFFYCKAHGPDVSHLGWLPLSCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGPHGAFWLFGVVCIVGLFFVIIYVPETRGKSLEEIERKMMGRVPISAVVNIKPFSFNM
Fails to transport trehalose.
B4HNS1
P54017
RL2_METJA
50S ribosomal protein L2
Methanocaldococcus
MGKRLISQRRGRGSSVYTCPSHKRRGEAKYRRFDELEKKGKVLGKIVDILHDPGRSAPVAKVEYETGEEGLLVVPEGVKVGDIIECGVSAEIKPGNILPLGAIPEGIPVFNIETVPGDGGKLVRAGGCYAHILTHDGERTYVKLPSGHIKALHSMCRATIGVVAGGGRKEKPFVKAGKKYHAMKAKAVKWPRVRGVAMNAVDHPFGGGRHQHTGKPTTVSRKKVPPGRKVGHISARRTGVRK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
P54017
Q6A9J5
WHIA_CUTAK
Probable cell division protein WhiA
Cutibacterium
MALTLQVKNELATVPVQKLCCRRSEIAATLRFAGGIHLVQHRHLTIEAEVDTGGAARRLRQSIQEVFGFDTDLVVVNGAGLHSNTRYLIRMVRGGADLARLTGLLDRRGRPVRGLPVPIVGGGRCCQAAAWRGAFLARGSLTEPGRSMAMEITAPGEEAAMALVGAARRLDITAKQRESRHVDRVTIRDGDAISAMLTRMGAHESVLAWEDRRLRREVRASANRLANFDDANLRRSARAAVTASARVERALEILGDSVPDHLRAAGRLRLEHRNASLEELGKVHEPPLTKDAIAGRIRRLLALADKTARSNGEPTTLESLPVEMRDDRG
Involved in cell division and chromosome segregation.
Q6A9J5
Q21452
LIAS_CAEEL
Lipoic acid synthase
Caenorhabditis
MLARVWVRGLAATKKKPQVLVKDGPSLQDFISSASVAEAVEKYEGKLKLEKGDRRLRLPPWLKKEKILPSENENVSRLKKQLKHLKLATVCQEARCPNLGECWGGSDDSLATATIMLMGDTCTRGCKFCSVKTARAPPPLDPMEPENTSTAVASWGVEYIVLTSVDRDDLPDGGADHLRKTVQLMKLKKPELLIECLLPDFAGDKISVEKMATSGLDVYAHNIETVERLTPWVRDPRAKYRQSLDALRYAKEVSPKLITKTSIMLGLGEAEDEIKQCLADLRASNVDVVTFGQYMQPTKRHLLVKEWVTPEKFDQWAEYSKKLGFLYVASGPLVRSSYKAGEFYLKNVLRNRQN
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Q21452
Q136E4
QUEF_RHOPS
PreQ(0) reductase
Rhodopseudomonas
MSRSPRKTPKSPSLQLGQAVEWPATPDAARLDRVPNPQAGTDYLVRFTAPEFTSLCPVTGQPDFAHLVIDYAPGAWLVESKSLKLYLASFRNHGGFHEDCTVSIGKRIAAEIKPKWLRIGGYWYPRGGIPIDVFWQTGKLPKGMWVPDQGVAPYRGRG
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Q136E4
O47688
COX3_TRASP
Cytochrome c oxidase polypeptide III
Tragelaphus
MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMILLMLGLTTNMLTMYQWWRDIIRESTFQGHHTPVVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLDPLEVPLLNTSVLLASGVSITWAHHSLMEGHRNHMLQALFITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGTTFLIVCFFRQLKFHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
O47688
B1MBZ5
BIOD_MYCA9
Dethiobiotin synthase
Mycobacteroides abscessus
MTILLVTGTSTGVGKTVATAALAAAAVRQGIDVTVCKPVQTGDDHDAGEVARLSGVTRVQTLVRYPEPLAPVASASRAGLELLDHTQMATAIVALDRPGALTLVEGAGGLLVELAADGKTLRDLAMVLDAPVLVVTTADLGTLNHTALTLEALAVQSVPCAGLVVGSFPAEPDLAQRLNRENLANQFGTPVRAVIPEGAARLMPPVFAELSIELFEPQWVAGLVA
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
B1MBZ5
A3PLU2
RUVB_CERS1
Holliday junction ATP-dependent DNA helicase RuvB
Cereibacter
MTSSDPTLRPERLPEDMDRALRPQSLEEFVGQAEARANLRVFIESARMRGEAMDHTLFHGPPGLGKTTLAQIMARELGVGFRMTSGPVLAKPGDLAAILTNLEPRDVLFIDEIHRLSPVVEEVLYPALEDFALDLVIGEGPAARTVRIDLQPFTLVGATTRLGLLTTPLRDRFGIPTRLQFYTEDELDLIVARGARMMGVDSDPEGTREIARRARGTPRIAGRLLRRVVDFALVEGDGRLTQAIADRALTRLGVDHLGLDLGDRRYIGLIAENYGGGPVGIETIAAALSESRDAVEEVIEPYLLQQGLIQRTPRGRMLAHKAWRHMGIEPPKGPGQSDLFG
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
A3PLU2
P29590
PML_HUMAN
Tripartite motif-containing protein 19
Homo
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYRQIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPEEAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENLADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQHFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPGASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFASLQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPAFNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS
Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response . Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity .
P29590
Q9PU85
PIM3_COTJA
qpim
Coturnix
MLLSKFGSLAHICSPASMDHLPVKILPPVKVEKEPFDKVYQVGSVLGSGGFGTVYAGSRTADGLPVAVKHVVKERVTEWGTIGGVMVPLEIVLLKKVGSGFRGVIKLLDWYERPDGFLIVMERPELVKDLFDFITEKGALDEDTARGFFRQVLEAVRHCYGCGVVHRDIKDENLLVDLRTGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLYFRRRISPECQQLIKWCLSLRPSDRPTLEQIFDHQWMHKSEVVKSEDCDIRLRTLDTDVSSTSSSNESL
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation.
Q9PU85
Q6NET5
PCKG_CORDI
Phosphoenolpyruvate carboxykinase [GTP]
Corynebacterium
MSTVSIKGLEGEAPTKNEVLLNWIAENVELFQPDRVVFADGSQEEWDRLTTQLVESGTLIRLNEEKRPNSFLARSNPADVARVESRTFICTPTPEGAGPTNHWADPAEMKAELTERFRGSMKGRTMYVVPFCMGPINDPAPKLGVQLTDSEYVVLSMRIMTRMGAEALAKIGDTGSFVPCLHSVGAPLEPGQEDVAWPCNEEKYITHFPETKEIWSYGSGYGGNAILAKKCYALRIASVMAKEEGWMAEHMLILKLTSPEKKVYYIAAAFPSACGKTNLAMLQPTIDGWSAEVVGDDIAWLRFGEDGRLYAINPENGFFGVAPGTNYSSNPNAMRTMEPGNTLFTNVALTDDGDIWWEDLENMPEHLTDWLGNDWTPESSQPSSHPNSRYCVPLAQCPVAAEEYNDPQGVPISAILFGGRRPDTVPLVSQAHNWDHATMIGALLSSGQTAAAEGTVGALRHDPMAMLPFIGYNAADYLQHWIDMGKKGGDKMPEVFLVNWFRRGDDGRFLWPGFGDNSRVLKWIVDRIEGRVEADETIAGYTARVEDLDLTGLDTPIEDIREALSAPAAQWKSDLADNEEYLTFLGSKGSAVPAEVLEQFEALKARVAAAES
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Q6NET5
A8FP22
RS10_CAMJ8
30S ribosomal protein S10
Campylobacter
MERIRLKLKAYDHRVLDRTVAAIVEAVKRTGADIRGPIPMPTKIKRYTVLKSPHINKDSREQFEIRIHARMLDIVAATPDTVDSLTKLDLAPEVSVEVRAMGK
Involved in the binding of tRNA to the ribosomes.
A8FP22
Q6L1W3
ATGT_PICTO
Archaeal tRNA-guanine transglycosylase
Picrophilus
MEILFRENLARIARFKTPHGEIETPTVMPVINPNLNFLDESTLRSYGVQAVITNSYIIKRNQRLNEDALRHGLHSLIKFSGPIMTDSGTFQSHVYGDIEYSNKEIVDFQKAIGSDIITILDVFTEPDESYNSARSKVIETYKRLKEIDFEDKIIAGPVQGSIYPDLRRLSAYLMSDALYLPIGGVVPLLESYRYSDLVKIIFNSKVSSDFSRPVHLFGGGHPMFFAFAVMLGVDLFDSASYIKYAKDNRLLYSEGTRALNDIREFPEWSPIHGKYTPQELLHEESEKRTRMLALHNLKSIFIEINEIKERIYENTLYNYVEEKARSHPALFKAFMSMINYDTSDYSPLSYKSPFFYYDKTSLNHPIIKRIMKFTENYISNSRHTLIISSKYWRPGVKNENVIKNIVECTDFNLLVSWNGIYIPLFLEDSYPVQQLVSSGLNDKKLEEDYLKRLKSINNDIEFYEGEHYDKRLRDYDTEKINTIAMFQFNINERFFDKSNIIKSKSTGHIRNIIEDNNIIATMRNDGYLTLSIKGAYRLLSMKPWPGLRVVVDDESGRFNANGYNVFFKFIKSFDTGIIPGNETLVVSEDDDLYAVGKAAVSGIEMYYYKSGVAVKVHEGVNKKAA
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Q6L1W3
C1B0C2
PSD_RHOOB
Phosphatidylserine decarboxylase beta chain
Rhodococcus
MARKPTPPGTPQPTSVGHIVDLVRGAVPPLHPAGLPFVLAPLGVAVLGRNRKWVRRGALTSAAACAAFFRHPHRVPPNRVGVAVAPADGEVALVDSAVPPSELDMGTEPLPRVSIFLSVLDVHVQRSPVGGEVTKVVHRSGQFLSADLADASEVNERNSMLLHTAEGHDVAVIQIAGLLARRIVCDAKVGDTLPIGDTYGLIRFGSRVDTYFPAGTTLLAERGQRTIGAETVIAQLP
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
C1B0C2
Q9JSY6
UPPP_NEIMA
Undecaprenyl pyrophosphate phosphatase
Neisseria
MDFLIVLKALMMGLVEGFTEFLPISSTGHLIVFGNLIDFHSNHKVFEITIQLGAVLAVVFEYRQRFSNVLHGVGKDRKANRFVLNLAIAFIPAAVMGLLFGKQIKEYLFNPLSVAVMLVLGGFFILWVEKRQSRAEPKIVDVDALRPIDALMIGVAQVFALVPGTSRSGSTIMGGMLWGIERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFVAAFVSGLVAVKALLRFVSKKNYIPFAYYRIVFGIAIIILWLSGWISWE
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q9JSY6
A6NJ69
IGIP_HUMAN
IgA-inducing protein homolog
Homo
MCSYYHMKKRSVSGCNITIFAVMFSHLSAGKSPCGNQANVLCISRLEFVQYQS
Enhances IgA secretion from B-cells stimulated via CD40.
A6NJ69
A1KUK1
ISCS_NEIMF
Cysteine desulfurase IscS
Neisseria
MTVKTPVYLDYAATTPVDKRVAEKMIPYLTETFGNPASNSHAFGWEAEEAVEKARADIAALINADPKEIVFTSGATESDNLAIKGAANFYKTKGKHLITVKTEHKAVLDTMRELERQGFEVTYLGVQENGLIDLEELKAAIRDDTILISVMWANNEIGVVQDIPAIGEICRERKIVFHVDAAQACGKVPVDVEAAKIDLLSMSAHKVYGPKGIGALYVRRKPRVRLEAQMHGGGHERGFRSGTLPTHQIVGMGEAFRIAKEELEQDMAHYRKLRDIFLKGIEGIEEVYINGDLEHRAPNNLNVSFNFVEGESLIMAVKELAVSSGSACTSASLEPSYVLRALGRNDELAHSSLRITFGRMTTEEEVQFAAELIKSKIGKLRELSPLWEMFKDGIDLNSIEWAAH
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
A1KUK1
Q9JM55
TOB2_MOUSE
Transducer of erbB-2 2
Mus
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLRKKYEGHWYPEKPLKGSGFRCVHIGEVVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGVVKVLYLGDSEASGTPELDKEIKSSFNPDAQVFVPIGSQDSSLSSSPSPSFGQSPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGASGGVSVGGSGAGGQQPPPQQPRMARSPTKNLLKHKSLSLSMHSLNLIPANPAPQSQLSPNAKEFVYNGGGSPSLFFDGVEGPSTSTTAPFGSGGASTCNSSSFDVSQVFGGGANSLFLEKSPFVEGLSYNLNTMQYPNQPFQPVVLAN
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Q9JM55
Q31WF1
IDI_SHIBS
Isopentenyl pyrophosphate isomerase
Shigella
MQTEHVILLNAQGVPTGTLEKYAAHTADTLLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTNSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQAANSEARKLLSAFAQHN
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Q31WF1
Q21VE7
KUP2_ALBFT
Probable potassium transport system protein kup 2
Rhodoferax
MSRTSNRESLAALTLGAMGVVYGDIGTSPLYTMKEVFSPATGVPLDGVHLIGAVSVIFWGLMMVVTLKYVLLILRADNRGEGGIMALTALAANAAGKTARRRTVLLLMGVFGAALFYGDSVITPAISVLSAVEGLEVVTPAFKSYVLPISVTVLIGLFAVQRFGTSLVGKLFGPVIMLWFAVLSVTGVAEIIQQPAILAALNPLNAFEFLRSQGWHMFVAVGAIVLAFTGVEALYADMGHFGKRPIQLAWLGLVLPALAINYMGQGALLMRDPSALANPFYRLFPQAWLMPAVVLATLATVIASQAVISGAYSMTKQAVLLGLLPRMQVQYTSAKEIGQIYMPEVNWLLLISVLLAVVGFGSSSALASAYGIAVTMTMLITTALTFFVVRDGWGYPLPVALAATAVFLALDTLLVVSCSLKFFQGGWFPLVLGLVIFTVMATWRRGRELLIDNIRHDDPELLPFITALSADVVHRVPRTAVYTVANPDTVPQALMHNLKHNQVLHERNVILTVVFHDVPWIAFDERVQVKPLVPGFWKVQVNYGFKNAPDIPRALELCQSQGLSINLFETSYFLSREIVVPTKGAGMAHWREALFAIMSRNAGSVADFFRLPNNCVIELGTRVQI
Transport of potassium into the cell.
Q21VE7
B8XA41
SBS_SOLHA
(-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
Solanum subgen. Lycopersicon
MIVGYRSTIITLSHPKLGNGKTISSNAIFQRSCRVRCSHSTPSSMNGFEDARDRIRESFGKVELSPSSYDTAWVAMVPSKHSLNEPCFPQCLDWIIENQREDGSWGLNPSHPLLLKDSLSSTLACLLALTKWRVGDEQIKRGLGFIETQSWAIDNKDQISPLGFEIIFPSMIKSAEKLNLNLAINKRDSTIKRALQNEFTRNIEYMSEGVGELCDWKEIIKLHQRQNGSLFDSPATTAAALIYHQHDKKCYEYLNSILQQHKNWVPTMYPTKIHSLLCLVDTLQNLGVHRHFKSEIKKALDEIYRLWQQKNEQIFSNVTHCAMAFRLLRMSYYDVSSDELAEFVDEEHFFAISGKYTSHVEILELHKASQLAIDHEKDDILDKINNWTRTFMEQKLLNNGFIDRMSKKEVELALRKFYTISDLAENRRCIKSYEENNFKILKAAYRSPNIYNKDLFIFSIRNFELCQAQHQEELQQFKRWFEDYRLDQLGIAERYIHDTYLCAVIVVPEPELSDARLLYAKYVLLLTIVDDQFDSFASTDECLNIIELVERWDDYASVGYKSEKVKVFFSTLYKSIEELVTIAEIKQGRSVKNHLLNLWLELVKLMLMERVEWFSGKTIPSIEEYLYVTSITFGARLIPLTTQYFLGIKISEDILESDEIYGLCNCTGRVLRILNDLQDSKKEQKEDSVTIVTLLMKSMSEEEAIMKIKEILEMNRRELLKMVLVQKKGSQLPQICKDIFWRTSNWADFIYLQTDGYRIAEEMKNHIDEVFYKPLNH
(2Z,6Z)-farnesyl diphosphate cyclizing enzyme. Produces (+)-alpha-santalene, (+)-endo-beta-bergamotene, (-)-endo-alpha-bergamotene, and at lower amounts, (-)exo-alpha-bergamotene and (+)-epi-beta-santalene. Not able to use geranyl diphosphate, E,E-farnesyl diphosphate or E,E,E-geranylgeranyl diphosphate as substrates, but able to use Neryl diphosphate to make the monoterpene terpineol.
B8XA41
Q8LK61
GAPN_WHEAT
Triosephosphate dehydrogenase
Triticum
MAGTGVFADVLDGEVYKYYADGEWRASASGKTVAIVNPTTRQTQYRVQACTQEEVNKVMDAAKVAQKSWARTPLWKRAELLHKAAAILKEHKTPIAESLVKEIAKPAKDAVSEVVRSGDLVSYTAEEGVRILGEGKLLVSDSFPGNERNKYCLSSKVPLGVVLAIPPFNYPVNLAVSKIGPALIAGNSLVLKPPTQGAVAALHMVHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGGDTGIAISKKAGMVPLQMELGGKDACIVLEDADLDLVAANIVKGGFSYSGQRCTAVKVVLIMEAVADTVVEKVNAKLAKLKVGPPEDDSDITPVVTESSANFIEGLVMDAKEKGATFCQEYRREGNLIWPLLLDHVRPDMRIAWEEPFGPVLPVIRINSVEEGIHHCNASNFGLQGCVFTRDINKAIMISDAMESGTVQINSAPARGPDHFPFQGLKDSGIGSQGITNSINMMTKVKSTVINLPSPSYTMG
Important as a means of generating NADPH for biosynthetic reactions.
Q8LK61
A0LE46
RSMG_MAGMM
16S rRNA 7-methylguanosine methyltransferase
Magnetococcus
MENFRYEIESMLQLVGVDMDVISVDPYSDEKLAEFVSELLLWNKKINLIGKSTEKSIWSRHIAESLILLPYVQGSTVLDMGTGAGLPGLPLQIVSGSNIEMHLVEKDQKKVSFLKHVSANLNLKNIRIYNKQFTEKGFDGAPLVNVVTSRALAEINQLVAWADPCLVNGGSLVLIKGPVCKAELEKFEESDLSDKYENGEIVEYKIDSHDVNIVIIKKK
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
A0LE46
Q9YGJ6
3S1A1_NAJSP
Alpha-neurotoxin NTX-1
Naja
MKTLLLTLLVVTIVCLDLGYTLECHNQQSSETPTTTGCSGGETNCYKKSWRDHRGYRIERGCGCPSVKKGIEINCCTTDRCNN
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
Q9YGJ6
C1F1B8
MSRA_ACIC5
Peptide-methionine (S)-S-oxide reductase
Acidobacterium
MAKATFGAGCFWGVEASFRQLHGVQDVAAGYEGGKLDNPTYRDVCTDLTGHAEVVEIDFNPDEIRFEQLLEAFFGLHDPTQLNRQGPDWGTQYRSVIFYHSPEQQTVAQAFIDRLTAEKRFPRPIVTQVVPAATFWRAEEYHQRYLEKRGLATCHI
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
C1F1B8
A6V936
DAPE_PSEA7
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Pseudomonas
MTASSPSLSPTLELACELIRRPSVTPVDADCQALMMRRLEAAGFALEPMRIEEVDNFWARRGGDGPVLCFAGHTDVVPTGPVQAWQHQPFDALIDEQGMLCGRGAADMKGSLASMIVAVERFVADHPGHKGAIAFLITSDEEGPAHHGTKAVVERLAARGERLDWCIVGEPSSTSLVGDVVKNGRRGSLGARLTIRGVQGHVAYPHLAKNPIHLAAPALAELAAEHWDDGNAFFPPTSFQISNLNSGTGATNVIPGELSALFNFRFSTESTVEGLQKRVEAILDKHGLDWHVEWALSGLPFLTEPGELLDAVAASIKAVTGRETRPSTSGGTSDGRFIATMGTQVVELGPVNATIHQVNERVLASDLELLTEIYYQTLVRLLA
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
A6V936
Q5AZ85
RGLB_EMENI
Rhamnogalacturonate lyase B
Aspergillus subgen. Nidulantes
MRLGVCFSLAAAASVARAALTATENDTSIVLENDRLRATFDKGRGSIIDLYLDGQDFLGPQSGSTGIGPYLDCYCTPSGFYTAGSTNPVTELVQGTDSTGTKYAGIILNDTYTPTGQEFQQYWFLRDGETGFHMFSRLAYYNETTPFLRNLQELRTLFRPNTDLWTHLTSSDLQTAPLPSDEAIAEQIVVQDATWRLNNTPDDAYYQQFSEYFTKYTFSNHWRDNDVHGLYADGSTSDGTTYGAWLVMNTKDTYYGGPLHSDLTVDGIIYNYIVSNHHGEGTPNITNGFDRTFGPQFYLFNGGGSSSLEELRDEARSLASPSWNADFYDSIAKHVIGYVPSSQRGSVKGTIKLPKNAKSPIAVLTVDGHYFQDNSAVPSSHQYWADIDKNGRFSIDRVVAGKYRLTVYADGIFGDFTRDGIVVKARKSTSIKETWKPESAGTEIWRLGTPDKSSGEFRHGAARDPTHPRHPPEYLIYWGAYDWQSDFPGGIDYMIGESDPATDFNTVHWAVFGPTPDNPVAESNTTHDWRIRFDLSAKQLHARKTATLTIQLAGAKAASGNTDVYNASEPYANLPLRSYINEQEEPLTMVIGYDQSSSCIVRSAVSCYQVREKWEFPASWLKEGSNLLRLSLPTNGTNYESAVLPTSVYVQYDALRLELK
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin. Active against linseed rhamnogalacturonan.
Q5AZ85
A7HL08
RIMP_FERNB
Ribosome maturation factor RimP
Fervidobacterium
MSLSQKEIIERVRAIAEPIVTSMGLELFDVKYRIQAGKWVLSIIIDKLDDYVSTRDCELVSYEIEKVLDSHDFIPGRYYLEVSSPGLDRPLKKIEDFRRFVGKLVKVKTKKTYRGYIVDVNMETKEIILRVDNENITIKYDDVKSANLEIEL
Required for maturation of 30S ribosomal subunits.
A7HL08
Q67IC4
NU2C_ASPOF
NADH-plastoquinone oxidoreductase subunit 2
Asparagus
MIWHVQNENFILDSTRILMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDRPWFYFISSTSLVMSITALLFRWKEEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKRDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALISTTVGIGFKLSPAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVSFGLRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIEWSMTVCVIASTIPGISMNPILAIAQDTLF
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Q67IC4
Q57RG9
HUTG_SALCH
Formiminoglutamate hydrolase
Salmonella
MTQWYPASPALWQGRDDSIEAPDARRLFQTVTRSETFFPENWQQKIALMGFACDEGVKRNSGRPGAAGAPDALRKALANMASHQGHERLVDLGNWVAPTPDLEGAQQALRDAVSRCLRAGMRTLVLGGGHETAFGHGAGVLDAFAQESVGIINLDAHLDLRQTDRATSGTPFRQLAQLCDAQSRAFHYACFGVSRAANTQALWREAQWRNVTVVEDLDCHDALAQMTQFIDKVDKIYLTIDLDVLPVWEMPAVSAPAALGVPLIQVLRLIEPVCRSGKLQAADLVEFNPRFDEDGAAARVAARLGWQIAHWWR
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Q57RG9
B0TUS0
SEQA_SHEHH
Negative modulator of initiation of replication
Shewanella
MKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESVVQDAPEEISHPSLERVSPKPVKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFILDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSANPKEIGQSGFWVTTNNNTAKKRTILSEVLLQFGTDEAQVTDIIEKI
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
B0TUS0
B5XLX5
DLTA_STRPZ
D-alanine-activating enzyme
Streptococcus
MIKDMIASIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGIWTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
B5XLX5
P48124
RK12_CYAPA
50S ribosomal protein L12, cyanelle
Cyanophora
MSSKTDEILEQLKGLTLIEAADLVKAIEEAFGVDASAPVGGGMVMMAPAAGGGADAAEEKSAFDLVLEEVPADKKIAVLKVVRSLTNLGLKEAKDLVEATPKVVKEGASKDELKQLKKNLKQLEQK
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
P48124
B6JM18
SECA_HELP2
Protein translocase subunit SecA
Helicobacter
MIKAIIGKIIGTRNDRWIKQYKKQVLTINALEPTYEKMSDVELQNAFEELKKRVRSTEKDLQEKTLLEVLPESFAITREASKRILKMRHFDVQLIGGMVLNDGKIAEMKTGEGKTLVATLAVALNALKGESVYVVTVNDYLAHRDSKEMEPLYHFLGYSVGTITASVRDDDERLEIYSKDIVYGTNNEFGFDYLRDNMKYSLEHKVQKSHAFAIVDEVDSILIDEARTPLIISGPVDRRMENYNKADEVAKSMQVEIDFTIDEKNRAILITEEGIKKAENLFGVDNLYKIENAALSHHLDQALKANYLFFIDKDYIVANNEVVIVDEFTGRLSEGRRFSEGLHQALEAKEGVSIKEESQTLADITFQNYFRMFSKLAGMTGTAQTEATEFLEIYNLEVVSIPTNLAIKRKDLNDLIYKSEKEKFDAVILKIKELHDKGQPVLVGTASIEKSETLHALLKKERIPHTVLNAKQHTKEAEIIKDAGLKGAVTIATNMAGRGVDIKLTDEIKELGGLYIIGTERHESRRIDNQLRGRSGRQGDPGTSQFYLSLEDNLLRIFGSDRIKGVMEKLGLKDGEHIESKLVTRAVENAQKKVENLHFESRKHLLEYDDVANEQRKSVYKFRDELLDASYDIGAKIAENREYALNQIFSKLKAFDHQNLSEEELLGLKNVLKEDFNAHVALEDLEKASPIEKFVAEKLKSDYENKMKVLDSEQRSRIERIVYLQILDNAWREHLYTMDNLKTGINLRGYNQKDPLVEYKKESYNLFLEFIEDIKIEAIKTFSKIQFENEQDSSDAERYLDNFSEEREHESVTYRHEETLDEDLNVAMKAFAKTPKRNEPCPCQSGKKYKDCCAKSGPKKGLFAK
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
B6JM18
A0RQJ3
EFTU_CAMFF
Elongation factor Tu
Campylobacter
MAKEKFSRNKPHVNIGTIGHVDHGKTTLTAAISAVLSRRGLAELKDYDNIDNAPEEKERGITIATSHIEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIVVFMNKADMVDDAELLELVEMEIRELLSEYDFPGDDTPIISGSALQALEEAKAGNDGEWSAKIMDLMAAVDSYIPTPVRATDKDFLMPIEDVFSISGRGTVVTGRIEKGIVKVGDTIEIVGIRDTQTTTVTGVEMFRKEMDQGEAGDNVGVLLRGTKKEDVERGMVLCKPKSITPHTKFEGEVYILTKEEGGRHTPFFNNYRPQFYVRTTDVTGSITLPEGTEMVMPGDNLKITVELINPVALEDGTRFAIREGGRTVGSGVVSKIIA
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
A0RQJ3
A5F850
FABA_VIBC3
Trans-2-decenoyl-[acyl-carrier-protein] isomerase
Vibrio
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
A5F850
A7IHF1
GCSH_XANP2
Glycine cleavage system H protein
Xanthobacter
MTSVRYTKDHEYVRVEGDVAVVGISDYAQQQLGDVVFVELPEIGKVVTKGGEAAVVESVKAASEVYAPLSGEVVEVNSELEGAPGLVNEAPEGKGWFMKLKLSNPAELDELLNEHAYKDFLDTLA
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
A7IHF1
Q8GXE6
AKT6_ARATH
Shaker pollen inward rectifier K(+) channel
Arabidopsis
MEKKKVWFWGVKDDGEGGGGRGGGRTKDAEDDVADHLSRDGTMSQYSLSKGLLPSLGANNRSSRDVILPRFIVSPFDPRYRAWETFLVFLVLYTAWASPFEFGFLQKPRPPLSILDNIVNGFFAVDIVLTFFVAFLDKVTYLLVDDPKRIAWRYASTWLIFDVVSTFPYEIFGSLLHESIQGYGIFSMLRLWRLRRVSNCFARLEKDRKYSYFWVRCSKLLLVTLFVIHCGACFLYSIAAHYPDPSKTFMALTDENWKESPIAVRYNTAMYWSITTFSTTGYGDIHGVNSREMTFILFYMVFNLGLSAYIIGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNLPVRLQDQMVAHLCLRYRTDSEGLQQQEIIDSLPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQLVTEMKAEYFPPKEDVILQNEAPTDFYILVTGAVDIIARVNGVEQVVSEAQRGHVFGEVGVLCYRPQLFTVRTKRLSQLLRLNRTVLLNLVQANVGDGAIIMNNLLQHLKDSEDPVMKGVLADTEHMLAQGKMDLPLSLCFAAARGDDLLLHQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIRDSEGNVPLWEAIIGRHREIAKLLAENGAKLSLDSVSYFSGLAVEKNCLDALKDIIKYGGDVTLPDGNGTTALHRAVSEGHLEIVKFLLDQGADLDWPDSYGWTPRGLADHQGNEEIKTLFHNHRPVEKKPKPIPGIPQSPVTGKPLMKYSSEPTMHSGELVLDGGQVVVSQKRKLNNFRNSLFGIISAANSADDGGEVPRSPAVPGGGGSMIYPERVTISSPENGETGGKVVLLPNSMEELLKIGENKMGFVPTKVLTREGAEIDDITLIRDGDFLLLSRDP
Highly selective inward-rectifying potassium channel that could mediate potassium uptake in the pollen membrane. Plays an important role in pollen tube development. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.
Q8GXE6
Q8CUN1
ARGJ_OCEIH
Arginine biosynthesis bifunctional protein ArgJ beta chain
Oceanobacillus
METTTVKEISILKNGHVTSPSGFYAGGVHCGLRRKKLDLGWIYSDTPASAAGVYTQNTFQAAPLLITKHTIEHSKQIQSIIVNSANANSFTGKQGYEDALLMQKLVANQLNIEQHHVAVASTGVIGERLPMDKVRNGIRQLSHTQVDAESFEKAILTTDTSTKHVAVQVEIDGKLVTIGGAAKGSGMIHPNMATMLSFITTDANVNQDSLQQALRKVTDQSYNQITVDGDSSTNDMVLVLANGRAENNELNESHPEWSVFMDAWNIVAIELAKMIARDGEGATKLIEVIVKGASTNQQASQIAKAVISSNLVKTAIYGNDANWGRIIGAIGYSGVPVEASKLSIAIGGIQVVNNGEPIDFDEKDCKQALNQETVNIVIDLQSGMDTATAWGCDLTYDYIRINASYRT
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
Q8CUN1
P23194
URIC_DROVI
Urate oxidase
Drosophila
MFATPLRQLSSLKRSGIAGQEQAQLYEITNKGYGKDAVKVMHINRKGPVHSIQELEVGTHLKLYSNKDYMLGNNSDVVATDSQKNTVYLLAKKHGIESPEKFALILAKHFLSTYAHVEEVHVHVEAYPWQRMTQDVSDNIGKGYCENNCNSRSNGNCQLHNHAFIFTPTAHDYCDVILTRQDPKQTVISGIKGLRVLKTTQSSFVNFVDDEFRTLADQYDRIFSTVVECSWEYSDTESVNFLHAWETVKDIVVRNFAGDPSVGIPSPSVQHTLYLSEKQVLDVLPQVSVVSMTMPNKHYFNFDTKPFQQLVPGENNEVFIPTDKPHGTIYAQLSRKSLKSHL
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
P23194
Q14FG1
PSBC_POPAL
Protein CP-43
Populus
MKTLYSLRRFYPVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGIGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRALVWSGEAYLSYSLGALAVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFLFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Q14FG1
Q1C0H5
RSMA_YERPA
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Yersinia
MNNRVHQGHFARKRFGQNFLNDQFVIDSIVSAIHPVPGEAVVEIGPGLGALTEPVAARMDHMTVIELDRDLAARLASHPQLKDKLTIHQQDAMKVNFSELSEQAGQPLRVFGNLPYNISTPLMFHLFSYTDAIRDMHFMLQKEVVNRLVAGPNSKTYGRLTVMAQYYCNVIPVLEVPPTAFTPAPKVDSAVVRLIPHVQMPHPVGDVRMLSRITTQAFNQRRKTVRNSLGDLFTSEQLIELGIDPILRAENISVAQYCKLANWLSAQSTPQK
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q1C0H5
A9GM39
COBD_SORC5
Cobalamin biosynthesis protein CobD
Sorangium
MTAAAALLVAVAFDLACGEPPAAVHPVVWMGSAIQALKRAAPAGGRAAELLFGALMALAVPCFFAALGAGVAALLAPHPVLALALSGLLLKPTFALRALRDAAYGVRDALEAGDVTGARGALRSLCSRDPSELDEPALVAASVESVAENASDSFVAPLFYFALFGLPGALFYRAVNTLDAMVGYHGRYEYLGKASARLDDALNFVPARLTALLLLAAGWLRGADARRGLAVLLRDGGLTESPNAGRPMAAMAGLLRVELEKRGHYRLGDPVEPLRRGLIDEACRIVVLATLLFAGLAAALLAAVSFGLGQELFR
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
A9GM39
P24882
COX2_ASCSU
Cytochrome c oxidase polypeptide II
Ascaris
MNNFFQDFNLLFSSSLFSSYMDWFYNFNCSLLFGVLSFVSTMFVYLLLSSFYFKSKKIEYQFGELLCSVFPTLILVMQMVPSLSLLYYYGLMNLDSSLTVKVTGHQWYWSYEFSDIPGLEFDSYMKSLDQLELGEPRLLEVDNRCVVPCDVNIRFCITSGDVIHSWALPSMSIKLDAMSGILSTLSYSFPVVGVFYGQCSEICGANHSFMPVALEVTLLDNFKSWCVGLLSD
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P24882
P93028
UBE11_ARATH
Protein MODIFIER OF SNC1 5
Arabidopsis
MLHKRASEANDKNDNTIIGSDLASSKKRRIDFTESSSDKSSSILASGSSRGFHGDSVVQQIDMAFGNSNRQEIDEDLHSRQLAVYGRETMRRLFASNVLISGMHGLGAEIAKNLILAGVKSVTLHDERVVELWDLSSNFVFSEDDVGKNRADASVQKLQDLNNAVVVSSLTKSLNKEDLSGFQVVVFSDISMERAIEFDDYCHSHQPPIAFVKADVRGLFGSVFCDFGPEFAVLDVDGEEPHTGIIASISNENQAFISCVDDERLEFEDGDLVVFSEVEGMTELNDGKPRKIKSTRPYSFTLDEDTTNYGTYVKGGIVTQVKQPKLLNFKPLREALKDPGDFLFSDFSKFDRPPLLHLAFQALDHFKAEAGRFPVAGSEEDAQKLISIATAINTGQGDLKVENVDQKLLRHFSFGAKAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQFFYFDSVESLPSEPVDSSDFAPRNSRYDAQISVFGAKFQKKLEDAKVFTVGSGALGCEFLKNLALMGVSCGSQGKLTVTDDDIIEKSNLSRQFLFRDWNIGQAKSTVAASAAAVINPRFNIEALQNRVGAETENVFDDAFWENLTVVVNALDNVNARLYVDSRCLYFQKPLLESGTLGTKCNTQSVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSSPVEYTNSMMSAGDAQARDTLERIVECLEKEKCETFQDCLTWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSAPKRFPRPLQYSSSDPSLLNFITATAILRAETFGIPIPEWTKNPKEAAEAVDRVIVPDFEPRQDAKIVTDEKATTLTTASVDDAAVIDDLIAKIDQCRHNLSPDFRMKPIQFEKDDDTNYHMDVIAGLANMRARNYSIPEVDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGGHKVEAYRNTFANLALPLFSMAEPLPPKVVKHRDMAWTVWDRWVLKGNPTLREVLQWLEDKGLSAYSISCGSCLLFNSMFTRHKERMDKKVVDLARDVAKVELPPYRNHLDVVVACEDEDDNDVDIPLVSIYFR
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
P93028
B3PI66
HSLV_CELJU
ATP-dependent protease subunit HslV
Cellvibrio
MTTILSVRRDGQVVIGGDGQVSLGNTVMKGNARKVRRLYKNQVLAGFAGGTADAFTLFERFEAKLESHNGQLTRAAVELAKDWRTDRSLRRLEALLAVADKEASLIITGNGDVIQPEDDLIAIGSGGMYAQAAARALLENTQLDARNIVEKGLKIAGDICVYTNQNHTIEVLDY
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
B3PI66
P10999
LAML3_XENLA
Lamin-B3
Xenopus
MATSTPSRAREHASAAQSPGSPTRISRMQEKEDLRHLNDRLAAYIERVRSLEADKSLLKIQLEEREEVSSREVTNLRQLYETELADARKLLDQTANERARLQVELGKVREEYRQLQARNSKKENDLSLAQNQLRDLESKLNTKEAELATALSGKRGLEEQLQEQRAQIAGLESSLRDTTKQLHDEMLWRVDLENKMQTIREQLDFQKNIHTQEVKEIKKRHDTRIVEIDSGRRVEFESKLAEALQELRRDHEQQILEYKEHLEKNFSAKLENAQLAAAKNSDYASATREEIMATKLRVDTLSSQLNHYQKQNSALEAKVRDLQDMLDRAHDMHRRQMTEKDREVTEIRQTLQGQLEEYEQLLDVKLALDMEINAYRKMLEGEEQRLKLSPSPSQRSTVSRASTSQTSRLLRGKKRKLDETGRSVTKRSYKVVQQASSTGPVSVEDIDPEGNYVRLLNNTEEDFSLHGWVVKRMHMSLPEIAFKLPCRFILKSSQRVTIWAAGAGAVHSPPTDLVWKSQKTWGTGDNIKITLLDSTGEECAERTLYRVIGEEGETDEDFVEEEELERQFRSQSHQSVDPSCSIM
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
P10999
Q750L0
AEP3_ASHGO
ATPase expression protein 3
Eremothecium
MNKIVHKVAEAFRKNGVPRTKWLNPKTIYGLANQKLLGSVEAPHAQGTGLNTVPQVEHYTKACRTKQRDMVRSYLEATGSTHFARLNTPAYNKSSALEFYAKLKALQRYTEGEEVLFQMSSVEVREIISRLVKLTQEGDQIPDEQRRFPTELFMDVAPVPNFNDDPGILEQYIGILTHSAFYYHNTSKIDPIPHILRDLLHPQNEKTASLRTTTMFNDLIYYFGKKSDYASCREYYSQMKLEKKTPNIETYRLLFLNLLKNMQIPKKQLPYKEMIFYLNDMEKFGVPADAKIWAYCYHLLVESVSKKLLLEKMIQHNAPISPDFIVSILRTLDVDCKAILEFAKEYSIPFTPKLLRLCISKLCKEYKFESAWQLLTSLCRSTDVVTTGSVNILLNAAAEKGRLDLAVLTYNSMKVQLGVTPDLRTHRLIFKAMARNGYHENFQDVYHWAVWSMKRSTSGWFVHDAWSRRCESMIKQKCGSVTPPTTENMEKVAAILHRGVWDNRGLFIRCWGEYKELRHVFRLLGSIPPAYKGKTA
Required for respiration.
Q750L0
Q9FJH5
HIP3_ARATH
Heavy metal-associated isoprenylated plant protein 3
Arabidopsis
MGEKKNEGDNKKKGGDNKKKNETPSITVVLKVDMHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLREKLEEKTKKKVDLVSPQPKKEKEKENKNKNDEDKKKSEEKKKPDNNDKKPKETPVTTAVLKLNFHCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKGTMDVKKLVEILSEKLKRAVEIVPPKKEKDKENGNENGEKKKGGGGDGGGKEKTGNKGGGEGVNMMEYMAAQPAYGYGYYPGGPYGYPIQAHAPQIFSDENPNACVVM
Heavy-metal-binding protein. Binds high amounts of zinc. May act as an upstream regulator of the salicylate-dependent pathogen response. Involved in abiotic stress responses, and seed and flower development.
Q9FJH5
A5CW05
IF1_VESOH
Translation initiation factor IF-1
Candidatus Vesicomyosocius
MSKSDYIELEGFVKEKLPNTTFMVELENGHCILAHISGKIRKHYIRILPGDKVTVEMTPYDLTKGRITFRHK
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
A5CW05
D0Z9R0
TATD_EDWTE
DNase TatD
Edwardsiella
MLDIGVNLTNGQFSGDVPQVVARARQAGLNGMIITGTNLTESAQALHLAQAYPDFCWATAGVHPHDAHRWNENSAADLEPLLRSPAVVAVGECGLDFARNFSTPAQQEAAFEAQLALAAQIGKPVFLHCREAHARFIALLRPWLSRLPGAVLHCFTGTRDELDACLSLGLYIGITGWICDERRGMPLRALLPHIPAERLLLETDAPYLLPRDIQPKPKSRRNEPCFLPHIAEQAARWRQQDANWLKQVTENNARQLFRLA
3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
D0Z9R0
B8F4X7
DER_GLAP5
GTP-binding protein EngA
Glaesserella
MTPVVALVGRPNVGKSTLFNRLTRTRNALVADFPGLTRDRKYGHANIAGHDFIVIDTGGIDGTEEGVEEKMAEQSLLAIKEADVVLFLVDARAGLLPADVGIAQYLRQRNKTTVVVANKTDGIDADSHIAEFYQLGLGEVEPIAAAQGRGVTQLIEQVLAPLAEKLEAQAVDSDENVADDEQDEWDSDFDFDNEEDTALLDEALEEDQEETDDKNIKIAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGQQYTIIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDARDGVSDQDLSLLGFILNAGKSLVIVVNKWDGLSQDIKDNVKSELDRRLDFIDFARVHFISALHGSGVGNLFSSIQEAYQCATKKMTTSMLTRILQLAMDDHQPPLVNGRRVKLKYAHPGGYNPPIIVIHGNQIEKLPDSYKRYLSNYFRKSLKIIGSPIRVLFQEGNNPFAGKKNKLTPSQLRKRKRLMKFIKKSKR
GTPase that plays an essential role in the late steps of ribosome biogenesis.
B8F4X7
Q8UA92
PANC_AGRFC
Pantoate-activating enzyme
Agrobacterium tumefaciens complex
MRLVKTVAELRDAIAAFRRAGKTIGFVPTMGFLHIGHLTLVARAKAENDATVVSIFVNPLQFGANEDLARYPRDLARDSALLQEAGVDILFAPDVTEMYPRPIQTVVDVPELGSQLEGAVRPGHFAGVTTVVTKLFNLVQPDAAYFGEKDYQQVTLVRRMVEDLAQPVRVIPVATVREADGLACSSRNVYLSPEQRAAAVIVPHALDEAERLYAEGVDDPAAIEAAIEKFIAAEPLASPEVVAVRDPDTLAPVASLQAGPVLVALFVRFGSTRLLDNRVIGREKTAEQEAAQ
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q8UA92
Q9XS41
SODM_HORSE
Mn-SOD
Equus
MLCRAACSTSRKLVPALGSLGSRQKHSLPDLQYDYGALEPYINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHTIFWTNLSPNGGGEPKGKLLDAIKRDFGSFDKFKEKLTAVSAGVQGSGWGWLGFNKDQGRLQIVACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVSERYMACKK
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Q9XS41
Q32686
RBL_NICPH
Ribulose bisphosphate carboxylase large chain
Nicandra
SVGFKAGVKEYKLTYYTPEYKTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYRIERVVGEKDQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALFKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFVEQDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAQEGNEVIREACKWSPELAAACEVWKEIVFNFAAVDILDNK
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
Q32686
B9E1X0
ARGC_CLOK1
N-acetyl-glutamate semialdehyde dehydrogenase
Clostridium
MVQVGVIGGTGYVGAELIRLLSNHNKIKISGISSTSYEGKSINSLYPGFYDLKELVCEKDDEVIKRSDLIFLALPSGVSEPIVEKAVAKDKICIDMGADFRFKNESSYKKWYGKNFITPKLHESSVYGLPELNREYIKKSRVIGNPGCYATSVQIGVLPLISKGLIEEKGIIADCKSGLTGAGKTLSESSHFVNCNESFSAYKVANHRHTPEIEENLNSVSKEGVKLTFIPHLIPINRGILSTIYTTPKDPIDIEKIHQKYCEFYKEEPFVRILPLGKVSKINNVRLSNYCCISIHYDSENNKLIIISCLDNMIKGAAGQAIQNMNIVLGFDEKEGLTALPAVF
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
B9E1X0
Q32DS4
MEND_SHIDS
Menaquinone biosynthesis protein MenD
Shigella
MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGVNQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKAALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLQQWQASCEPVEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKCQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRVCDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPKSERECFYLMPQNVHFEHAAAMFELKYHRPQNWQELETVLADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
Q32DS4
Q7VLT4
FTSB_HAEDU
Cell division protein FtsB
Haemophilus
MRLMIVFFGLLLFFFQYSFWLGKNGWQDYKNAKLEVQRLTAENIKLNARNELIAAEIDDLKNGVDALEERARLDREMVKSDEYFYRIVPRN
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
Q7VLT4
B3E683
APT_TRIL1
Adenine phosphoribosyltransferase
Trichlorobacter
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARGFLIGAALAYRLGAGVVLVRKPGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADDLLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKLPEGKVYSLMQF
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
B3E683
P05047
LECA_SARPE
Lectin subunit alpha
Boettcherisca
MSLTMKNVEGFVIFLVIFTSTAAVPQLQKALDGREYLIETELKYNWHQAWHECARHDQQLVTIESADKNNAIIDLVKRVVGKSHNLWLGGNDEYSSSRDYGRPFFWSPTGQAFSFAYWSENNPDNYKHQEHCVHIWDTKPLYQWNDNDCNVKMGYICEPNHFRETYDQALKQKCEAIKITNSKISTEFDQLHAKQSLEFDSITQNVAKVNEDWKIEIQKLQNATQIAIQQIMENHEKKIRDLSDNLLKQLQDSNEQLKQSTDHMNASFGEKLKGQQAENNEIC
Role in the defense system of the organism against microorganisms. This lectin binds galactose.
P05047
Q3SS86
PPK1_NITWN
Polyphosphoric acid kinase
Nitrobacter
MDSIQAIAPEEKKPELELDSAIRASPERFINRELSWLHFNRRVLEESVNPGHPALERVRFLSISANNLDEFFMVRVAGIKAQVREGITERSPDGLTPSEQLVLINETVSDLASDQQAIWRDLRNMLAGVGIVLIDGKDVTKAERSWIADHFLHNIFPLLTPLAIDPAHPFPFIPSLGFTIALQLARTSDGKPMNALIRMPGKIDRFLRIPAASKDDPVRLITIEGATSLFINRLFPGYTVKGQGAFRIIRDSELEIEEEAEDLVRLFETALKRRRRGSVIRLEIEAAMPAELRAFVQRALSAADDEVLLVDGVLAMNELSQLTRLDRPDLEFVPYVPRHPERVRDHGGDVFAAIRQKDLIVHHPYESFDVVVQFLQQAARDPDVVAIKQTLYRTSNNSPIVRALAEAAEAGKSVTALIELKARFDEEANIRWARDLERAGVQVVYGFLELKTHAKLSLVVRREGGSLATYVHTGTGNYHPVTARIYTDLSYFTSDPIIGRDAARVFNYITGYAEPSDIERMAVSPLTLRNRILDHIRGETTFARNGKPAAVWMKMNALVDPDIIDALYEASQAGVSVELIVRGICCLRPGVPGLSENIRVKSVIGRFLEHGRIYCFGMGQTMPGPKAAVYISSADMMPRNLDRRVEVLCPLQNATVHQQVLEQIMVANLKDTEQSWRLLPDGSSTRMKAAKGEEPFNLHNYFMTNPSLSGRGKSLKESSPRRLTRRSERQPPA
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Q3SS86