accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q7VAW6
OTC_PROMA
Ornithine carbamoyltransferase
Prochlorococcus
MNMNSLSVSRVLADLAGKDFISCSDFTSDQVKALLQLSSQLKNGDRRIDLGNRVLGLIFSKASTRTRVSFQVAMARLGGQTIDLSNQATQLARGEPLKDTARVLSRYCDALALRTFGNDELIEYAKWSSIPVINALTDLEHPCQALADFLTIKEAFGSLDGITLAYIGDGNNVLNSLMICGTLLGVNIQIASPKGFEPLPSIVERAKTLAHPTLKICVSNNPIDAVSGAHVIYTDVWASMGQESEQAQRKEIFEGYTVNKDLVDKAEKESIILHCLPAHRGEEITDDVLESSASRIFDQAENRLHVQQALLAALLGGL
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Q7VAW6
Q5WJE6
HTPG_ALKCK
High temperature protein G
Alkalihalobacillus
MEKKQFQAESKRLLEMMVNSIYSQKEIFLRELISNASDAIDKMYYRSLTDDSLSFEKDRYAIYVEADKDNRKLVMKDTGIGMTKEELEANLGTIAKSGSLAFKKETEIEDGHDIIGQFGVGFYAAFMVADKVTVITRSIDSDQAYKWESDGTDGYTIEPAEKEDVGTVITLHIKENTDDESYDEYLEEYRIKAIIKKYSDFIRYPIKMNVTVSKPKEDNEDEYAEYQEEQTINSMVPIWRKNKSELKDSDYEQFYQDKRYGFDKPLEHIHVSVDGAIRYNAILFIPEHTPFDYYSKEYEKGLELYANGVLIMEKCAELLPDYFSFVKGMVDSEDLSLNISREMLQHDRQLKLIAKNIKSKIKSQLKTMLKKEPDKYEKFYKAFGRQLKFGVYNDFGANKDDLQDLLLFYSSTEKKLVSLSDYVSRMKEGQTYIYYATGESNERIAKLPQTEMVADQGYEILYFTEDVDEFAIKMLRSYDEKEFMSVSSADLDIETDEKQEEETNSEENKKLFEKMKSILDGKVKDVRTSKRLKSHPVFLAADGEITLEMEKVLQAMPDNQNVKAEKVLEINPNHDVFHSLKQAYEEDEDKLKLYTNLLYNQALLIEGLPLEDPVEFSQNMCKVMV
Molecular chaperone. Has ATPase activity.
Q5WJE6
Q5NZH8
GLND_AROAE
[Protein-PII]-UMP uridylyl-removing enzyme
Aromatoleum
MSTAAIPTDAAVQAAIAEARARLADGSMRIRMAYEGHPATSTVLKGRAHLVDETIHRLWRACAMPADVALLAVGGYGRGELFPCSDVDLMVLLPDTADDAMQARLSVLLGALWDVGLEIGHSARTVAEAIDAAEQDITVQTNLLESRLLEGNRPLFEEFCRRYRALLDVRVFFKAKQLEQEKRYARYNDTPYALEPNCKESPGGLRDLQMLGWIARAAGLGRNWRDLARRRLITGAEARDLRSIERFLQHVRIRLHYLTGRSEDRLLFDYQERLASALGIEATAAKRASEVFMQRYYVNAKKVTQTNTILLQNYGVEIFPRRAGAAIVINERFQAVRELLDMREDDTFARHPSALLECFLILQQRSELKGMTARTLRALWLNRKRINAAFRADPHNRELFVAILQQKRGIVHEFRRMNQYGILSGYLPSWRRIVGQMQHDLFHVYTVDQHIMMVLRNMRRFTMGEHAHEYPLMAQLIMAFDRHWLLYVAALFHDIAKGRGGDHSKLGTIDAREFCEHHHLAREDADLVVWLVEHHLTMSHVAQKEDTSDPAVIGRFADTVGTERRLTALYLLTHADIRGTSPKVWNGWKGKLLEDLFFATRRLLRGATPQEALGLDDRQENARALLRYHGLRPGVEDALWAQLDAVYFMRHSAEEIAWHSRTLYYRPDALEPVVKARVSDADQGVQVMVFTRDQKDLFVRLTGFFGRLGFSILDAKVHTTRHGYALDSFMLQDPGNAEHYRDVITLIEHELTERLKKSAPPDRPSAGRLSRQVKHFPITPRVSILPDESGRHYILSLTAADRRGLLFAVAEVLAQNGIVLHTAKIATLGERVEDTFLLSGNGLSQDARVVKIERELLQRLHI
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
Q5NZH8
B6EN06
IHFA_ALISL
Integration host factor subunit alpha
Aliivibrio
MALTKADLAETLFEKVGLSKRDAKETVEVFFEEIKQALESGEQVKLSGFGNFDLREKSERPGRNPKTGEDIPISARRVVTFKPGQKLKARVEDLPVEK
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
B6EN06
Q02181
PHEG_SYNPY
Phycoerythrin class II gamma chain, linker polypeptide
unclassified Synechococcus
MLGAETSLQALTSATRTGPAAFSTKSKAGKNTVPRTVAGAIAEYKRQHCAAMGIGIGPRLLSECPFAVTFDRYSPDSSAALERVIVAAYRQVLGNLPPTDNQRETSLEVRLMNGEITVRDFVNGLAKSDFYKDNFFHAVGAQRGIELNFKHLLGRAPLNQQEVQNHIKLQAEEGFDALIDTLTDSAEYTEVFGADIVPYDRTKDSYAGMNTRSFNLMRDLGGMKVAISDNAQGRQSKTVNALASASRESTKPQPFSYVSVTQIPVKLPQQQYTGHNVPAMSDYVPFRPFGIFF
This protein is a bile pigment-bearing rod linker polypeptide that associates with C-phycoerythrin.
Q02181
B8DG43
LUXS_LISMH
Autoinducer-2 production protein LuxS
Listeria
MAEKMNVESFNLDHTKVKAPFVRLAGTKVGLHGDEIYKYDVRFKQPNKEHMEMPALHSLEHLMAELARNHTDKVVDISPMGCQTGFYMSFINFSDYDDALDVLAKTLADVLEAKEVPACNEVQCGWAASHSLEGAKELAEEFLAKRSEWKNVFGE
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
B8DG43
Q3B736
ATGA1_DANRE
Autophagy-related protein 101
Danio
MNCRSEVLEVSVEGRQVDEAMLGLLHTILLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTFVRVSSDELDRVIRKAVAEFKDALGNSGSDGMGQISLEFYQKKKSRWPFSDECIPWEVWSIKVNVVNLANEQERQICREKVGEKLGEKVINIVEVINRHEYLPKMPTQSEVDNVFDTSLKDVQPYLYKITYQITDSLGTSVSTTMRRLIKDTLAL
Autophagy factor required for autophagosome formation.
Q3B736
Q746H2
PARB_THET2
Probable plasmid-partitioning protein ParB
Thermus
MSRLDEVLGTAILKGKKALGKEAPEVLRLPLDLLRVRGQPRRRFENLEALAESIREKGILQPLLVRRVGEAYEVVAGERRLRAAAMAGLKEVPARVLDLSEKEARLLALVENLQREDLNPYEETLGVLALLSEDLGKSVEEVVGLLRKMKNAKEGRVRDNVVPTAEAQRVEELFKALGRMSWESFVQHRLPLLSLPEDLKAALEEGAIPYTAALELKKVKDASLRKALLEEVKAGLSLRELKARVRGVLRKEKAPRPWPKEVAAKLARLDLEALPPERRARVEELLAELERVLEGPR
Probably involved in plasmid DNA partitioning.
Q746H2
Q3SJE0
DAPE_THIDA
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Thiobacillus
MANETLEDAVLASETLALAVELLKRRSVTPDDAGCHDLIAARLQALGFHIERHRHNDVDNLWARRGTASPVVCFAGHTDVVPPGPLEQWLSDPFEPTLRDGKLYARGAADMKTSDAAFVTATERFLARRPDHPGSIAFLLTSDEEGPATDGTVRVVEALKARGELLDYCIVGEPTSAAEFGDTIKNGRRGSLSGTLRVKGVQGHIAYPHLAKNPIHLAAPAIAELAETMWDEGNSYFPPTTWQISNIHAGTGVTNVIPGMVEIQFNFRFSTASTAEGLMDAVNEILDSHGLDYEIDWNLSGKPFLTPRGALCDRLSEAVHEVTGLTPELSTTGGTSDGRFIADICREVVEFGPLNMSIHKLNEHVALENVEQLAAVYEKALEKLLGESDERV
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Q3SJE0
B2GJ18
RS13_KOCRD
30S ribosomal protein S13
Kocuria
MARLAGVDLPREKRLEVALTYIYGVGRTRALETLEATGISGDVRVKDLTDPQLVELRDYIEGNYKVEGDLRREVAADIRRKVEIGSYQGLRHRRGLPVHGQRTKTNARTRKGPKRTVAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B2GJ18
P07135
RR7_SOYBN
30S ribosomal protein S7, chloroplastic
Glycine subgen. Soja
MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAMKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPVEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
P07135
Q89AD0
ENGB_BUCBP
Probable GTP-binding protein EngB
Buchnera
MYLVDTIDYQKICCIIKTFEDNILFQKNYHSTWFLKSIANIQKEKYNYGLEVAFVGYSNSGKSSIINALTNQKKLAKISRTPGRTRLINIFSVTSEIRLVDFPGYGYAQVSRSISKKWKEMIFQYLNIQKCLQGLVIITDIRCPIKEIDELVINLAVSLNIPILLLLNKMDKVTRSIQKSKLFSTREKMLNFSNNINVELFSSFKKIGIHKLQFVLNNWFSSDKKLCQ
Necessary for normal cell division and for the maintenance of normal septation.
Q89AD0
Q6NZQ8
MARH1_MOUSE
RING-type E3 ubiquitin transferase MARCHF1
Mus
MLGWCEAIARNPHRIPNTTRTPETSGDVADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTANKLEKNFPCNVNTEIKDAVVVPVPQTGSNTLPTAEGAPPEVIPV
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Q6NZQ8
B8F3D3
GMHA_GLAP5
Sedoheptulose 7-phosphate isomerase
Glaesserella
MYQQQILIELQEAQQVLNDFINDQHNLKLIQEAALLITDSFKNGGKILSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDPSHLSCVSNDFGYEYVFSRYVEAIGQKGDILFCLSTSGNSKNVINAIIAAKAKGMKIIAMTGKDGGKIAELADIEIRVPHFRYADRIQEIHIKVIHILMMLIEFEMAK
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
B8F3D3
Q21IX0
HTPG_SACD2
High temperature protein G
Saccharophagus
MTAEATVETRGFETEAKQLLHLMIHSLYSNKEIFLRELVSNASDAADKLRFEALKQPELLEQDSELKITIDFDKEAKTLSITDNGIGMNRDEVIANLGTIARSGTAQFMANLSGDQKKDSQLIGQFGVGFYSAFIVADKVEVLTRRAGSEPSEGVRWVSEGEAEYSIENIEKAARGTTIILHLKKDQEEFADGWRLRSIIKKYSDHISLPVEMPKEAAPGEDKEEKAEVEYEVINTAKALWARSRSDVTDEEYKEFYKHVSHDYTDPLSWSHNRVEGKLDYTSLIYIPSKAPFDMYNREKPRGVKLYVQRTFIMDDAEQFLPLYLRFIKGVVDSNDLSLNVSREILQQDPNIDSMRSALTKRVLDMLEKMAKKEPEKYATFWKEFGEVLKEGPAEDFANKEKIAKLLRFATTHKNTNEQDQSLDAYIERMKEGQDKIYYVVAENFNTAKNSPHLEVFRKKGIEVLLLSNRIDDWLMGHLMEYDGKQFQDVGKGSLDLGKLDSEEDKKEQEKVEEAMAPFVERMKAALAEQVEEVRITHRLTESPACLVVGEHDMGAQMRRLLEAAGQAVPESKPIIEINPTHPLVQKLDQEQDEDRFKDLSHILFDQASLAEGGSLKDPAAYVSRLNKLLLELSN
Molecular chaperone. Has ATPase activity.
Q21IX0
A0M6M4
MURQ_GRAFK
N-acetylmuramic acid 6-phosphate lyase
Gramella
MNKKSPDTEKVSNYDYLEKMNTFELLSNINKEDHTIAENVKKQIPSIEKLVDEIIPRIDSGGRLFYIGAGTSGRLGVLDASECPPTFGVSPGIVIGLIAGGDTALRNAVENAEDDTNQAWKDLQEYDISEKDVLVGIAASGTTPYVIGGIKDARNNGIITGCITCSSGSPLAEASEYPIEVVTGPEFVTGSTRMKAGTAQKLVLNMISTSVMIKLGRVKGNKMVDMQLSNDKLVGRGIRMIMEDLNIEKEQAEKLLLEHKSVRKVLDAHKNERN
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
A0M6M4
P69883
CH60_STRP1
Chaperonin-60
Streptococcus
MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVHEGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLKTNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAKITVDKDSTVIVEGSGSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNATRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQIALNAGYEGSVVIDKLKNSPAGTGFNAATGEWVDMIKTGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPATPAPAMPAGMDPGMMGGF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P69883
B6YT50
RNZ_THEON
tRNase Z
Thermococcus
MLEVIFLGTGGIMPNRERNVPAIALRYKGEIILFDVGEGTMRQMSTAKLSPMKVEKIFITHFHGDHYLGLAALIQTMNLWNREKPLHIYGPKYTFRFIQNFLNSGFFRPGFDIHVHEIGEVRLKFGDYEIWSFKVEHGIPALGYVFKEKDKRGKFLPEKLAEYGLSEGPILGKLEKQGQIEWNGRIIRLEDVTGPRRKGVKVVYTGDTEPCERTRLFAENADLLIHEATYLRPEDRGDSYHTTVGEACEIAKKAKVKLLALFHRAFRYTYDEYMAKARELCDVPFVIPKDFDVLTFKSGRWEMRNLLEDWQ
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
B6YT50
Q0UZ59
DBP9_PHANO
ATP-dependent RNA helicase DBP9
Parastagonospora
MAMKRKLNEHDVPEPESPQSPKRRASDASQSEPASPPAPTPAKEVVASFAELQLEPRLLRGIRDQKWGSPTAVQSKAIPLALQGRDILARSGTGTGKTGAYLLPILHNTLLRKGKTSLILVPTKELALQITKVAKALSAHCGQAVRIQNIAGKESEVVTKAKLADNPDIVIATPARASANINTGALAVTELAHLVVDEGDLVMGYGFKEDLDQIAQNIPKGVQMFLMSATLNTEVESLGSLLCNDPVVLKLDDLDKDSKRVKQYVIKCAEEEKFLLIYAMFKLGLIKGKTIVFVGDTDRSYRVKLFLEQFGIKSCVLNSELPLASRLHIVEEFNKNIYNILIASDETEILGSQKKADESRPKKKPKTDKEAKNDSGVSRGIDFLNVSCVLNFDFPATYKSYFHRIGRTARAGKSGTAISFIIPKDKYRKHKSTTFAGCENDEEVLKKVEKHQEAGQKLENYNFDMKRLEPFRYRFGDALRSVTRIAIREARIKEIRLELSKSQKLSRYFEENPEALAHLRHDQTLNHPARIQPHLKHVPDYLLPGGSRKPADVGFVGLNVPRVNKRQYVKGKGRKVVRRNGKVDPLKTFNARGKGKK
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Q0UZ59
Q2JCI0
WHIA_FRACC
Probable cell division protein WhiA
Frankia
MTATVKDELSRLRVAKPCCRRAEMAALLRFGGGLHIVGGRIVVEAELDTGATARRLRREVAEVFGFPSTVAVLAAGGLRRSVRYIVRVERDGEQLARSTGLLDQRGRPVRGLPPQVVTGSACDAAAAWRGAFLAHGSLTEPGRSCSLEVTSPGPEAALALVGAARRLGVQAKSRDVRGVDRVVIRDGDAIGALLTRIGAHDSLLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVQAAMRILGDDAPEHLLAAGRLRIEHAQASLEELGALADPPLTKDAVAGRIRRLLALADKRANALGIPNTEASVSPDLLENA
Involved in cell division and chromosome segregation.
Q2JCI0
B7V1R2
PRMA_PSEA8
Ribosomal protein L11 methyltransferase
Pseudomonas
MPWLQVRLAITPEQAETYEDALLEVGAVSVTFMDAEDQPIFEPDLGTTPLWSRTHLLALFEADTDETALLAHLALLTGGDLPEHHVEEIADQDWERSWMDNFQPMRFGRRLWIVPSWHAAPEPDAVNLLLDPGLAFGTGTHPTTALCLEWLDGQELAGRQVLDFGCGSGILAIAALLLGAERAVGTDIDPQALEASRDNASRNGIEPARFPVYLPADLPQRQADVLVANILAGPLVSLAPQLTGLVRPGGLLALSGILAEQAEEVRAAYSAHFDLDPTAEREGWIRISGRRRAD
Methylates ribosomal protein L11.
B7V1R2
O75379
VAMP4_HUMAN
Vesicle-associated membrane protein 4
Homo
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAAILLLVIIILIVMKYRT
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
O75379
Q6NFV3
NDK_CORDI
Nucleoside-2-P kinase
Corynebacterium
MTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAEHADKPFFGELVNFITSAPLIAGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVSTNVVHGSDSPESAEREISIWFPNL
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Q6NFV3
Q5PHS1
TTCA_SALPA
tRNA 2-thiocytidine biosynthesis protein TtcA
Salmonella
MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTSLEALRLDVIEVK
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
Q5PHS1
Q6N0K6
NIKR_RHOPA
Putative nickel-responsive regulator
Rhodopseudomonas
MHRVTITLDDDLMEKLDAIIAARGYQNRSEAIRDLARIGIQQTAAETTSGHCVGAMVYTYDHSKRDLPRKLTQSFHHHHDLSRATMHVHLDHDQCLEVTILDGNATELQHFADHIFAERGVRYGRLVTIPAEPPAEGHEHHHEHDASS
Transcriptional regulator.
Q6N0K6
C1EQR2
MTNX_BACC3
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
Bacillus cereus group
MSIQVFCDFDGTITNNDNIMSIMEKFAPPEAEEVKNRILSQELSIQEGVSQLFQLIPTNLHDQIIQFLIETAEIRNGFHEFIQFVNENNISFYVISGGMDFFVYPLLQGLIPKEQIYCNETDFSNEYITVNWPHPCDRLCQNHCGLCKSSLIRKLSDTNDFHIVIGDSITDLQAAKQADKVFARDFLITKCEENHISYTPFETFHDVQTELKHLLEVKL
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
C1EQR2
Q6AQK0
GATC_DESPS
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Desulfotalea
MKISEKEVQHVAHLSRLHLDQDELASMTEQLDGILSYMEKLAEVDTEGVLPTTHAFSKTNAFREDIVKDSLSQEESLANGPVQNGTAFQVPRVI
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Q6AQK0
Q6XMH8
DROS_DROSI
Drosocin
Sophophora
MKFTIVFLLLACVFAMAVATPGKPRPYSPRPTSHPRPIRVRREALAIEDHLAQAAIRPPPILPA
Antibacterial peptide with strong anti-Gram-negative bacteria activity.
Q6XMH8
Q8JZM6
TIFAB_MOUSE
TIFA-like protein
Mus
MERPLTVLQVSLYHPTQGPVAFAHVPQQLQHDASRLLVGRGQNTHLQLQLPQLSRYHLSLEPYLEKGSSLLAFCLKVLTRKSCVWVNGLPLRYLEQVPLGTINRISFSGIQMLVRKEGGASLETFVCYFHLSPSPLIYRPKAQETDE
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
Q8JZM6
A8ACJ9
IBPB_CITK8
16 kDa heat shock protein B
Citrobacter
MRNYDLSPLLRQWIGFDKLANALQNTGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLDIQLEGTRLTVKGTPAQPEKEIKWLHQGLVTQPFSLSFTLAENMEVSGATFTNGLLHIDLTRNEPETIAPQRIAISERPALNS
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
A8ACJ9
Q5ATZ7
SFH5_EMENI
Phosphatidylinositol transfer protein sfh5
Aspergillus subgen. Nidulantes
MAEQAKLPDQAQPVPETQVPDNGKPEQQPTATESAPAPEPATTEPTTAATAPSAVDGTGETAPAAPEPAAAPVAAAAAAPAPEPTKSEPQPAVGEQSEPAKKDEPAKPEYFTKTPALEQFFDRLPTILSNTGHQEMWGVPLKHEVTDIPTINVLIKFLRANAGDLKAAEDQLSKALTWRKENDPIALADASKNSYDASKFKGLGYLTTYQREGKGDLVVTWNIYGAVKKFDETFGDITEFIKWRAALMELAVQELKLDQATSVIDYDGEDPYQMIQVHDYLNVSFLRMNPNVKAATKKTIDVFSTAYPELLREKFFVNVPAIMGWMFAVMKVFVNQNTARKFHPISNGANLAKEFPAGVAEKFPKAYGGSAPDLESSARTVALKEVKEEKKEEPKEGSKEEQKGEQKGE
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.
Q5ATZ7
Q07154
EXPB9_MAIZE
ZmEXPB9
Zea
MGSLANNIMVVGAVLAALVVGGSCGPPKVPPGPNITTNYNGKWLTARATWYGQPNGAGAPDNGGACGIKNVNLPPYSGMTACGNVPIFKDGKGCGSCYEVRCKEKPECSGNPVTVFITDMNYEPIAPYHFDLSGKAFGSLAKPGLNDKLRHCGIMDVEFRRVRCKYPAGQKIVFHIEKGCNPNYVAVLVKFVADDGDIVLMEIQDKLSAEWKPMKLSWGAIWRMDTAKALKGPFSIRLTSESGKKVIAKDIIPANWRPDAVYTSNVQFY
May aid fertilization by loosening the cell wall of the stigma and style, thereby facilitating penetration of the pollen tube. Acts selectively on grass cell walls, which are relatively poor in pectins and xyloglucans and rich in glucuronoarabinoxylans and (1-3),(1-4)-beta-D-glucans, when compared with cell walls of other angiosperms, including other monocots.
Q07154
Q46I07
ARGJ_PROMT
Arginine biosynthesis bifunctional protein ArgJ beta chain
Prochlorococcus
MKNALLNLSLLTSSVWSPISGGITAPDGFLAAGISAGLKPSGKKDLALLYAPDGACCSGTFTQSVTRAYCVDLCIDRIKASEGKIRAVVINSGHANACTGSRGKIDSEMITHKLAQLLRLSSEEVLICSTGVIGEAIPVEKVNSHLDQLINSLDKEAYLDAANAILTTDLQVKQIAYQAVLGGRRISIGGMAKGSGMIHPSMATMLSYLTCDVGVDHVLWSDMIKRVAESSFNSITVDGDTSTNDTFLAFASGAELDPRYLSILEEGLHLTAQHLAKSIARDGEGANCLLEIKVEGASSDLDARAIARTIASSSLVKTAVHGSDPNWGRIIAALGRAGTSFNLNDVKLWIGPYEIFSNGTPLDFDRQIVSNFMKARLTGKYLIDDLISIRLRIGIGTGSATAWGCDLSDQYVRINADYTT
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
Q46I07
Q03VA1
RF1_LEUMM
Peptide chain release factor 1
Leuconostoc
MDPIFQSLQTVIDHYDELNEQLADPEVMNNGQHYMKLSKEAGEIRQTVEVYTRYKQVIQDIQDAEELLGDAEMAPLAKEDLSALKPEKEQLEEQLKILMLPKDPNDDKNIIMEIRGAAGGDESSLFAADLLDMYRRYAERQNWSMSIIDESTTEVGGYKEVAVMITGDNVYSKLKFESGAHRVQRVPATETQGRVHTSTATVGVMPEFEEIDFELNESDLEEEFFRSGGAGGQNVNKVSTAVRLIHKPTGIMVKMQEERTQIKNRDKARKLLASRVYDFYAQQNESEYAAQRKSAVGTGDRSERIRTYNYPQNRVTDHRIGLTLNKLDRIMNGELGEVIDALVIADQTAKLAELNK
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
Q03VA1
Q8NH57
O52P1_HUMAN
Olfactory receptor 52P1
Homo
MESPNHTDVDPSVFFLLGIPGLEQFHLWLSLPVCGLGTATIVGNITILVVVATEPVLHKPVYLFLCMLSTIDLAASVSTVPKLLAIFWCGAGHISASACLAQMFFIHAFCMMESTVLLAMAFDRYVAICHPLRYATILTDTIIAHIGVAAVVRGSLLMLPCPFLIGRLNFCQSHVILHTYCEHMAVVKLACGDTRPNRVYGLTAALLVIGVDLFCIGLSYALSAQAVLRLSSHEARSKALGTCGSHVCVILISYTPALFSFFTHRFGHHVPVHIHILLANVYLLLPPALNPVVYGVKTKQIRKRVVRVFQSGQGMGIKASE
Odorant receptor.
Q8NH57
Q22235
ENPL1_CAEEL
Endoplasmin homolog
Caenorhabditis
MRFLLVGFVALLAVSAFIPNVYAEDEIEDAPKETKEETREEDSIKLDGLSVSQIKELRSKAEKHEFQAEVNRMMKLIINSLYRNKEIFLRELISNASDALDKIRLLSLTDPEQLRETEEMSVKIKADRENRLLHITDTGVGMTRQDLINNLGTIARSGTSEFLSKLMDTATSSDQQQDLIGQFGVGFYAAFLVADRVVVTTKNNDDDQYIWESDSASFTISKDPRGNTLKRGTQITLYLKEEAADFLEPDTLKNLVHKYSQFINFDIFLWQSKTEMVEEAVEEEPATTEDGAVEEEKEEKKTKKVEKTTWDWEKVNNVKPIWMRKPNQVEEDEYKQFYKSITKDSEEPLSHVHFSAEGEVSFRSILYVPKKSPNDMFQNYGKVIENIKLYVRRVFITDDFADMLPKYLSFIRGIVDSDDLPLNVSRENLQQHKLLKVIKKKLVRKVLDMLKKLDGAQFDDFWSEFSTNIKLGVMEDPSNRMRLAKLLRFQSSNDADKTTTLAAYVERMKEKQDAIYYMAGTSRKEVETSPFVERLIAKGYEVLFLTEAVDEYCIQAMPEYESKKFQNVAKEGVTIDDGEKAKEAHKGLEEEFKPLTDWLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDVSQDAQVETEQHIEEAEPEPEAAEETTIEEEHSEL
Molecular chaperone that functions in the processing and transport of secreted proteins.
Q22235
Q5X4X1
RS18_LEGPA
30S ribosomal protein S18
Legionella
MSAYFRRKKMCRFSAEGGNEIDYKDINLLKNYITETGKIVPSRITGTQTRFQRQLAKAIKHARFIGLLPYCDSHR
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q5X4X1
A4IJ94
PDXS_GEOTN
Pdx1
Geobacillus
MALTGTDRVKRGMAEMQKGGVIMDVVNAEQAKIAEAAGAVAVMALERVPADIRAAGGVARMADPTVVEEVMNAVSIPVMAKVRIGHYVEARVLEALGVDYIDESEVLTPADEEFHIDKRQFTVPFVCGCRDLGEAARRIAEGASMLRTKGEPGTGNIVEAVRHMRKVNAQIRKVVSMSEDELVAEAKQLGAPVEVLREIKRIGRLPVVNFAAGGVATPADAALMMHLGADGVFVGSGIFKSENPEKYARAIVEATTHYEDYELIAHLSKGLGGAMRGIDVATLLPEHRMQERGW
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
A4IJ94
Q99020
ROAA_MOUSE
CArG-binding factor-A
Mus
MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSAAAAAPAASAGSGGGTTTAPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQGSTNYGKSQRRGGHQNNYKPY
Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes.
Q99020
B0RB59
KAD_CLAMS
Adenylate monophosphate kinase
Clavibacter
MTRLLIVGPPGAGKGTQAKRIAADRGIPDVSTGDIFRQNIKDRTELGQQVQALVDAGNYVPDELTNRLVTVRLQEEDAQAGFLLDGYPRTLAQVAYLEELLQGWGQELDAVIQLVADEDEVVARLTRRAAEQGRADDGEDEIRHRQEVYVRETSPLIDVYREHGLLVEVDGLGEVDEVAERIRTALAARGVRPSSDAGRA
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
B0RB59
B1LW28
CLPP_METRJ
Endopeptidase Clp
Methylobacterium
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFLEAENPKKEISFYINSPGGVVTSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGHRFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLNEIYVKHTGRDYDTIHTALERDNFMTADAAKEFGLIDEVIEKRPEPAAA
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
B1LW28
Q82XI7
THIG_NITEU
Thiazole synthase
Nitrosomonas
MEPLVIAGKSYSSRLLLGTGKYRDFAETRAAVDASGAQIITVAIRRTNIGQNPDEPNLLDILPPSQFTLLPNTAGCYTAEDAVRTLRLARELLDGHALVKLEVLGDQKTLFPDVVATIEAAKILVKEGFQVMVYTSDDPIVARQLEDIGCAAIMPLASLIGSGMGILNPWNLQIIIDKATVPVIVDAGVGTASDAAIAMELGCDGVLMNTAVASARNPILMASAMRKAVEAGREAYLAGRMPRKIYQASPSSPAEGMFTGTQHPAANS
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Q82XI7
Q01674
FOXA_YEREN
Ferrioxamine receptor
Yersinia
MFSAFIIKRSAILCSLAMFIPLASIADDTIEVTAKAGHEADLPTSGYTATTTKGATKTDQPLILTAQSVSVVTRQQMDDQNVATVNQALNYTPGVFTGFSGGATRYDTVALRGFHGGDVNNTFLDGLRLLSDGGSYNVLQVDPWFLERIDVIKGPSSALYGQSIPGGVVMMTSKRPQFTSEGHFRLTAGNNNTQVAAFDYTDAISEHWAFRLTGITRNSDTMYDHQREERYAIAPSLLWQPDENTSLLLRANLQKDPSGGYHSAVPADGSIYGQKLSRGFFDGESNHNVFKRWQQIYSYEFSHKFDDVWSFRQNASYTHSNTQLEQVYQGGWNSDRTLMNRYYSGEDSSLNAFAVDNQLEADLRTAAVKHKVLLGVDFQKFRNNLRSDSAYATPLNPYTGVSGGSTLYSDYLLTTPGINTSYLSRRYEQSGVYLQDEMTLDNWHLNLSGRYDRMKTENINNTANSTDERTDNHASGRASLLYSFDSGISPYVSYSQAITPSLFPDAQQKLLKPMTSEQYEVGIIYQPPGSTSLYSAALYDLTQNDVANRAVPATYYVPAGKVNSQGLELEARSQISDRLSVIAGYTYNRVKFKDAIDGNDGNTPVLAPSNMASLWAQYEAGYGINVGAGIRYIGKQWADDANTLRVPSYTLGDASVRADLGTWAASLKGAFVQLNVNNIADKKYVAACYSTSYCYWGAERSVQATVGYDF
Ferrioxamine binding and uptake, in association with the TonB protein.
Q01674
Q48MF3
RLMF_PSE14
rRNA adenine N-6-methyltransferase
Pseudomonas
MTDTRKPPRKKPQRPAKPAAPREKATLHPRNRHQGHYDFAKLIKSSPELAAFVILNPYGKESIDFADPQAVRVFNRALLKAFYGIAHWDIPADYLCPPIPGRADYLHFLADLLAEDNEGVIPRGASIKALDIGTGANCIYPLLGHSDYGWQFVGSDIDSTAIAAATTIIKANGLSKAISVRQQDNRKQILLGLLDSSERFHVSLCNPPFHASLDEAQRGSQRKWRALGKADPKRKLPVLNFGGQSQELWCEGGEIGFVTRLIQESATLPSQVVWFSTLVSKASNLPPIQNALKKAGALEVKVIEMGQGQKQSRFVAWTFLDKAQRTPH
Specifically methylates the adenine in position 1618 of 23S rRNA.
Q48MF3
O26900
MOAC_METTH
Molybdenum cofactor biosynthesis protein C
Methanothermobacter
MMIMKEFTHTDEKGVRMVDVGSKPVVRRTATAEGHILLREDTINLIREKKIEKGNVLATAQIAAIVAVKRTWEIIPLCHPLPLTGVDVEFDLDDDRITARVTVRCDGKTGVEMEAVTGVSVALLTIWDMVKSVEKDDDGQYPETAISNIRVIKKEKLEL
Together with MoaA, is involved in the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).
O26900
P58426
TXHP2_HETVE
Toxin KJ6
Heteropoda
DDCGKLFSGCDTNADCCEGYVCRLWCKLDW
Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels.
P58426
Q6F6Z6
PYRE_ACIAD
Orotate phosphoribosyltransferase
Acinetobacter
MTTPSSFNPQAFIELALSRGVLKFGEFTLKSGRVSPYFFNAGLLNDGEALSLLAQGYADQLMQCQHVDVIFGPAYKGIPFVAATAVALSQLHAKSVPWGFNRKEAKDHGEGGVLVGASVEGKKVWIIDDVITAGTAIREVVTILKNAGATIAGVLVALDRQERGQGQLSAIQEVQQELEIPVHALITMKDLMNYLDAKGETQALAKMEDYRLKYGI
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Q6F6Z6
Q30Y32
NADK_OLEA2
ATP-dependent NAD kinase
Oleidesulfovibrio
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMVLGGDGTMLSVSRRAVGLDVPLLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLALHFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGEWLGDLRADGLIVSTPTGATGYAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQECFALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q30Y32
Q8TQR1
DNAJ_METAC
Chaperone protein DnaJ
Methanosarcina
MATKRDYYEILGLPKDASVEDIKKTYRKLALQYHPDRNKDPGAEDKFKEISEAYAVLSDTEKRAQYDRFGHAGIDNQYSAEDIFRGADFGGFGDIFEMFFGGGRRGGPMGPRRGSDLQYDLYITFEEAAFGVRKDIDIPRTERCSTCSGTGAKPGTSPKRCPTCGGTGQVRTTRSTLGMQFISTTTCSTCHGRGQIIESPCPVCGGAGRVRNKRTITVNVPAGADSGMSLRLSGEGDSGEPGAPSGDLYIIIHVMEHRHFKRVDYDVISELSITFTQAALGADVMVDTLYGKVKMNIPAGTQTHSVFRLRDKGIQRLHGHGKGDQLVRVIIKTPTKLNQEQKELLRQFENLSKGKKPQEEEKSKAEKHKKGIFEKVKDAFES
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Q8TQR1
A8Z673
RL22_SULMW
50S ribosomal protein L22
Candidatus Sulcia
MESNNYINFFFKKKKYTKSVADVRNIYCSPRKLRLVADIIRNKKVEYSLFILKNIKNKGGGIIYKILLSVISNWKNYENNINNYNIYIEKVLINQGYQLKKIRPGPQGRGNKVRKRYSNLKIIINSKFNNYYGT
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
A8Z673
P60742
RL24_MYCPA
50S ribosomal protein L24
Mycobacterium avium complex (MAC)
MKVRKGDTVLVIAGKDKGAKGKVLKAYPDRERVLVEGVNRIKKHTAISTNQRGAQSGGIVTQEAPIHVSNVMVVDSDGKPARVGYRLDEETGKRVRISKRNGKDI
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
P60742
Q3YUX6
METAS_SHISS
Homoserine transsuccinylase
Shigella
MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNKPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Q3YUX6
A8YWU7
METK_LACH4
Methionine adenosyltransferase
Lactobacillus
MERRLFTSESVSEGHPDKVADQISDAILDAMLEKDPNSHVACETIVTTGMVFVFGEISTNAYVDIQDVVRKTILRIGYDRPELGFDGNNCAVMVDIDEQSPDIAGGVDHSLETRENESDQDELDQIGAGDQGLMFGFAIKETPELMPLPISLAHRLMRRVASLRKDHTLDWLRPDAKAQVTVEYDENNNPLRVDTVVISTQTDAEVSNKEIRRAMIDLVIKEVIPARYLDEKTKFLINPSGRFVIGGPKGDSGLTGRKIIVDTYGGYARHGGGAFSGKDSTKVDRSASYAARYVAKNIVAAGLAYRCEVQLAYAIGVAHPVSIMIDTAGTGKVDDDLLTEAVRHVFDLRPAGIIKMLDLRRPIYEQTAAYGHFGRTDVDLSWEKTDKTQDLLDYIKNNK
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
A8YWU7
Q16AK0
RNH_ROSDO
Ribonuclease H
Roseobacter
MPELFAYTDGACSGNPGPGGWGVLLQAKEGDRLVKERALKGGEAHTTNNRMELLAAINALESLSRASTITVVTDSNYVKNGITGWIHGWKRNGWKNAAKKPVANAELWQRLDEANARHDVTWKWVKGHAGHAENERADELARAGMAPFKP
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q16AK0
Q09313
DCT6_CAEEL
Daf-16/foxo controlled, germline tumor-affecting protein 6
Caenorhabditis
MIESTTSHQDFQQRSMTGYALEHPSYRIRGALFRHQDDGRLLSGCGGDIEVIHALELERSQHTCLPVRVTNVVVFGSNDVVRLIQPIEGTEDVIVNGDYHVSIVQSVELFESSTVSKSRILKLPGKIIAVNAEKHSNTELLLVFLLETGIFHYSFCAHTSTHFQCIQAFRCNRPITSGLLWRDSGLLHVAYYDGFVRVGVVHEQYDDMLLVKRVAVNRNNLSVLLDVVFEEIGRIQKFEDTEKQRREDMLTTSKSLSDKLVAEEEVVEGDTTNDDFAKLKIEFKNQSIRCERVSQRLTSLRKLITIIKSALDMNDQIEQMISLLVDELSELEKLEQLCKEVERTGNQNLIGKSWIAVEEKQMVVEELIAKVNSDQIKKHSDVWEQKIDQIIDQLNGCSEAAKDMRLIISQNIFEHRGDKKDVFTHFVLDAQSRDITLYCLSGLTTMAIYPRKGKRVASISLDASFATCLTAACAMKSAEGVYVADQNNVFPTYFYRNRPKAGKGEKRYLDAGNQLQLPTFDSISSILVEPHQMILGSVTGGLLHLSFDFASNYEHFVVASSILAHPISSGSVNCIKLLATGESLLALHCTDTEIVVSEKDQERWHRVTHHTGGAHAIAVTPFSVDERGAFAVVASDTFVRLKVLQYAEESLIGLHDLGESRAEDENGHPIEVLNVSLDPSMQYRQLPCKLRYAVGFADKAIRTYVALLTGQHDFNVQEKFIAQIEPLFNVQNMICFHGRPMGCYVSCAKTLQIWNDLDRHQQKKLKSERMQLLKLSSSVTSMERAEGYLLLGFADDRLSIYEEKGNGAVDLVGTVDDWHKGLNDRIVMSLRTRASKTSCGTRLFIHSLTAHHIVIHTVLVTASKIEQHDFIVAHEHSMSQPIGFEFVSYKYFEFLVYGRGISNEKLSIEDRKRMDNFRDFEFN
May have a role in tumor suppression.
Q09313
B1J2D7
ILVC_PSEPW
Ketol-acid reductoisomerase type I
Pseudomonas
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVADVATAVAAADLVMILTPDEFQGALYKNEIEPNIKKGATLAFSHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYASGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINEESRKAMRNALKRIQDGEYAKMFISEGATNYPSMTAKRRNNAAHGIEVIGEQLRSMMPWISANKIVDKTKN
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
B1J2D7
Q6CAC9
UTP25_YARLI
U three protein 25
Yarrowia
MARSHKVTKPKRQQVDTSGSYNALMVLMGDNVKKAEKRVEEEEPVEQELEEDDIEGAGEEEEEVDEEQEEEEDADDAEEDAEDDSETDKYDPYKLHFEAEEAKYVSVIKSEEWKTSSEKTKIGSQPVRITYTNLEDADELLDFSEAQKTEFSKYTVRPRIKDGFKQLNGSLTSVQKAIYPSLMAYRDLCYATSSLSDTEEFSRLVAMHIAQHVVRTAEEVAYNTRILKRNAEEGIHDVEFRDQGYTKPRVLVLVPTKNACFEFMQLLVGASGVDREDNKARFNKAFHEAGAVLDTKPEDFQKAFKGNTDDMFCLGVKLRNKSIRYYSYFYQADIVFASPLGLKTLVGSEGDSKREFDFLSSIEIAYLHETNHMEMQSWDNVLTVLGQTNLLPNESHGCDFSRVKSFYLDGLAKHFRQTIVACQFVTPTINSVFSNTVNFAGKTKITPIYNGELAVAGMKIRQIFTRFKALSVSDEIDARFKAFVQITLEGMIRSGDYSGTLIYVPTYVELVRLRNYMDEKNISFGAISEYSSITEVKRHRTLFRDGREKILLYTGRLHHYRRYFVKGVKSVVIYKLPENPAFYRELLLFLTHSVDEGTLEQSMAKCRALFTIYDLLALERIVGTKRVKTMAKSGESSYEFY
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Q6CAC9
Q4WAX0
FTMG_ASPFU
Fumitremorgin biosynthesis protein G
Aspergillus subgen. Fumigati
METLDAIQLPYLGVVGASLIVILGIILLFPLGSDPFITINQHPRDLFQTKAKQQFEYNAAALLNEGLQTGHSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDPVLLVDLPGLESMFQGSLHNQVPPMAVRALNKELVHLTPSLSEEAMNCLQTRWTDSTEWHGVSIPETVLALIAQMTTRALLGPELCRNPEWLDIAKSFTTNRAIAVAAVQSWPSFLQPVIHWFLPPCRALRRQIQCARNIILPALERERRAYCSDQPTKREFSNLVFIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIEPLREEVVSVVGNHGLHRHSLRKLTLMESVMKETQRLEPAVIIGMFRLAKEKVTLKDGTVVPKGTNIAFANDLRFDPEMYLEPETFDGYRFQRMREDPAKIDLAPFTKTRMSHLAFGHGKHACPGRFLACDEAKLILCHILLNYDIRAVEGSPPELPGSWGNDVGEKTAGD
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities . The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA . Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B . The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively . The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B . Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties . In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Q4WAX0
Q9HUX4
NASLL_PSEAE
Nicotianamine synthase-like enzyme
Pseudomonas
MQGRTPLLETLRELECEIRLLTVYARECCGCYEILRRKLDRLSGLIGEDCSRAQWQADSDDPALQALGLRLRDAAVQALCELEKHLCQGVLHEPGEMGRYLGSLLESIRGELDSAGIDADARVLFVGSGALPTSALVLAREVGAHLCCLDIDEEALGCAREIARCQGLEARMQFSSLPPAELAFSRDATHFLIASLVQQKSAVLAQIRQVMRADAKVLLRHGSGIKGLFNYPVEPAELDGWRVCAERVSQPLYDTLILEKAGR
Catalyzes the nucleophilic attack of one alpha-aminobutanoate moiety from SAM onto L-histidine to produce the intermediate (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate. Functions in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Appears to be specific for L-histidine as substrate.
Q9HUX4
Q32IR3
YBEY_SHIDS
Endoribonuclease YbeY
Shigella
MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTILVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q32IR3
A8Z6D9
END4_CAMC1
Endonuclease IV
Campylobacter
MRYIGAHVSAAGGVSNAPINAAKIGANAFALFTKNQRQWSAKELSEGEIEQFKANLKASGISADHVLPHASYLINLGHPEKEARAKSLEAFIDEIERASKLGLKLLNFHPGSHLKQISQNECLDNIARCINEALKRTSGVKLVIENTAAQGSNLGFDFAQLAYLIERVDDESRVGVCIDTCHAFAAGYDLRSKEAYAKTMGEFDAVIGYKFLSGMHLNDAKFGLGSKKDRHESLGKGELGLGAFENIINDDKIGEIPLILETIDESIWEDEIKILRNLEKEKL
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
A8Z6D9
P93394
UPP_TOBAC
UMP pyrophosphorylase
Nicotiana
MAAQNKAMSGNRMLVFVPPHPLIKHWVSVLRNEQTPCPIFRNAMSELGRLLMYEASRDWLPIITGEIQSPMGVASVEFVDPREPVAIVPILRAGLALAEHASSILPATKTYHLGISRNEETLQPSVYLNKLPDKFPEGSRVIVVDPMLATGGTIVAAIDLIKERGVDNSQIKVICAVGAPPALQKLSEKFPGLHVYAGILDPTVNDKGFIIPGLGDAGDRSFGT
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
P93394
Q1LQS4
CH60_CUPMC
Chaperonin-60
Cupriavidus
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVGAAVEELKKLSKPTTTSKEIAQVGAISANSDASIGERIAEAMDKVGKEGVITVEDGKSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQVAKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTVIAEEIGLTLEKATLQDLGQAKRIEIGKENTIIIDGAGDASAIEGRVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALLRARAAIAGLHGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNAASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAESPKEESAPAMPGGMGGMGGMEGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Q1LQS4
Q824U5
PYRH_CHLCV
Uridine monophosphate kinase
Chlamydia
MSKRITRVLFKISGESLSTDSGNRIDEVRLSRLVSELRAVRNSDIETALVIGGGNILRGLAQQKELQINRVSADQMGMLATLINGMAVADALKADDIPCLLTSTLSCPQLADLYTPQKSEEALSQGKVLICTTGAGSPYLTTDTGAALRACELKADILLKATMHVDGVYDKDPLMFTDAVKYDRISYKDFVAQGLGVMDVSAVSLCMDSNIPIRVFSFVKHSLEQAIFDENIGTLICGDA
Catalyzes the reversible phosphorylation of UMP to UDP.
Q824U5
A9KSC2
HEM12_LACP7
Glutamyl-tRNA reductase 2
Lachnospiraceae
MNISMVGIDYNTASIEDREHFTLTSDKQLEIAKIIKETYHASGCIILSTCNRTEIWFSELGTSEAECFHQLVLGENAKETMRSICVCRQGDEAVTYLMELGCGIHSQIFGEDQILTQLKQALQQARDYQYVDSVLECLFRTAITAAKKVKTSIQIAKGNTSLPQTIVEQLEKEQGDLLGKSCLVIGNGEMGRLMTEKLLEKKCKVWMTLRQYKKSKAIIPEGSGVVLYDERYEHIAVMDYIFSATKSHHFTINKSMFENIRLKGKTYCLIDLAIPRDIEPSVEELSDVTVYNMDYFCQEVNDREKELEETRELLSEYVNEFKQWYQFRNLVSTVDDISNIVSDITDAKLTKVYKSIDLSREQQELLQSNVQMAAKKAVSKIIFGLRDVLQIDQCEEVLQALEQSAMNCTDSVK
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
A9KSC2
Q9ERQ3
ZN704_MOUSE
Glucocorticoid-induced gene 1 protein
Mus
MQARRLAKRPSLGSRRGGAAPAPAPEAAALGLPPPGPSPAAAPGSWRPPLPPPRGTGPSRAAAASSPVLLLLGEEDEDEEGAGRRRRTRGRVTEKPRGVAEEEDDDEEEDEEVVVEVVDGDEDDEDAEERFVPLGPGRALPKGPARGAVKVGSFKREMTFTFQSEDFRRDSSKKPSHHLFPLAMEEDVRTADTKKTSRVLDQEKETRSVCLLEQKRKVVSSNIDVPPARKSSEELDMDKVTAAMVLTSLSTSPLVRSPPVRPNEGLSGSWKEGAPSSSSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRSPAPPDDGIDEADASNLLFDEPIPRKRKNSMKVMFKCLWKSCGKVLNTAAGIQKHIRAVHLGRVGESDCSDGEEDFYYTEIKLNTDATAEGLNTVAPVSPSQSLASAPAFPIPDSSRTETPCAKTDTKLVTPLSRSAPTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFSISWQSPPVTFTGVPVSPPHHPTAGSGEQRQHAHTALSSPPRGTVTLRKPRGEGKKCRKVYGMENRDMWCTACRWKKACQRFID
Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.
Q9ERQ3
A9YTQ3
AHRR_HUMAN
Class E basic helix-loop-helix protein 77
Homo
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
A9YTQ3
Q9V2X0
FLAB2_THEKO
Flagellin B2
Thermococcus
MFRGLKKRGAVGIGTLIVFIAMVLVAAVAAAVLINTSGYLQQKASSTGRETTQEVASGLKIMKVIGYDPADPPASGKIERLAVYVSPNAGSSGIDMKKVRVILSNGDKQAIYNYYVPESGTFVSETTTTLKLAFATSEPDWTSGGTGLDFSAGLKIVFDASGSLTIADGNGNSVSINRFTITTDTSNNYYGDSGTNDYKETFTTDSASNYYLYSQYDAVIVLFDQNGNVVGKLPLKAGANTIVVEAYDIDASSLSNIDYLVIYNKDFPDSKITWGVPQNLDKAGTTVTVVDVTTNNQVTLDSDGDFSLGAINVADYNDPNSGTGDVMFEIDYSLGSETTPKLGGDDTVTLKFLQDNSGTPTPVSLDLSVVDDQTSSGTDYYIYTGHAVFYASENATIVLGDTKIPIKAGPNVVDIYAEDKGNSADGTDVDYIKVTINGVSFEWGTQGQENNAFSGTVAQIKDVNIDVIDSTDGLYGAAFTGFDNVNGGIFGDANGAWAALRANTNFGIIALQDADGSLKATTPTLTEGDIAVLTLDVKGIFGGFAPRTHITGKVVPEFGAPGVIDFTTPTSFNSNVIELQ
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
Q9V2X0
P0A2E9
FLIA_SALTI
Sigma-28
Salmonella
MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVDRYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAMGQLEQELGRNATETEVAERLGIPVAEYRQMLLDTNNSQLFSYDEWREEHGDSIELVTEEHQQENPLHQLLEGDLRQRVMDAIESLPEREQLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.
P0A2E9
Q1QEM6
THIC_PSYCK
Thiamine biosynthesis protein ThiC
Psychrobacter
MTISDIGSQATTHTPVKASKADALKTPAHRSETDARFEEDARDLHRILPASRKVYIEGSRPDIQVPMREITLDPTPIQGVSESEWEQNPPFYVYDTSGVYTDPNAAIDLTKGLPKLREGWIDERGDTEQLAGLSSSYGLARARDISTANLRFAHIDKPRRAKAVDGKVGNVTQLHYARRGIITPEMEYIAIRETQKQHELTDMRQHEGETFGAHTPAIITPEFVRSEVAAGRAIIPNNINHPESEPMIIGRNFLVKINANIGNSALGSSIDEEVSKMTWATRWGADNIMDLSTGNHIHETREWLIRNSPVPIGTVPIYQALEKVDGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLEYVPLTAGRLTGIVSRGGSIMAQWCMFHNKESFLYTHFEDICEIMKQYDVAFSLGDGLRPGCLQDANDEAQFGELRTLGELTQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEVCADAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNALSKARFEFRWDDQFNLALDPDTAREFHDETLPKDAHKTAHFCSMCGPKFCSMKITQNVREYAKGLNAQ
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Q1QEM6
A1WVA8
RS8_HALHL
30S ribosomal protein S8
Halorhodospira
MSMTDPIADMLTRVRNAHHAEKADVRMPSSKLKRAIAAVLQEEGYIEGYREVGEEKKPVLEVTLRYHEGQPAIREIQRYSRPGLRVYRGRDELPRVRNGLGTAIISTSKGVMSDGQARAQGHGGEVLCWVF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A1WVA8
P57893
RUVA_PASMU
Holliday junction ATP-dependent DNA helicase RuvA
Pasteurella
MIGHLTGRLVEKHPPEILLDVQGVGYELLLPMTSFYQLPDIGQQTALFTHLVVREDAHLLFGFSQKTDRTLFRELIKTNGVGPKLALAILSAMSVEEFAYAIEREELSKLVKIPGVGKKTAERLLVELKGKFKGIQQEDFFIESQHLKQPEHALNEQDIPASEAISALIALGYKAAEAEKLVKKISKPALSSEQLIREALKAAL
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
P57893
Q09MG7
YCF4_CITSI
Photosystem I assembly protein Ycf4
Citrus
MSWRSEYIWVEFIAGSRKPGNFFWAFILFLGSLGFLVVGISSYLDRNLLSLFPSQQINFFPQGIVMSFYGIAGLFISSYLWCTIIWNVGSGYDRFDTKEGIVCIFRWGFPGKNRRIFLRFLMKDIQSIRIEVKEGIYARRVLYIESRGLGAIPLNRTDENLTPREIEQKAAELAYFLRVPIEGF
Seems to be required for the assembly of the photosystem I complex.
Q09MG7
B2T744
RL16_PARPJ
50S ribosomal protein L16
Paraburkholderia
MLQPKRRKYRKEQKGRNTGIATRGNAVSFGEFGLKAIGRGRLTARQIEAARRAMTRHIKRGGRIWIRIFPDKPISHKPAEVRMGNGKGNPEYYVAEIQPGKMLYEMDGVTEELAREAFRLAAAKLPLKTTFIVRQLGA
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
B2T744
A3PIB9
ATPB1_CERS1
F-ATPase subunit beta 1
Cereibacter
MATASQGKVTQVIGAVVDVQFDGGLPPILNALETENNGKRLVLEVAQHLGESTVRTIAMDATEGLVRGARVTDTGSPISVPVGDATLGRILNVIGEPIDEKGDLGEASTRAIHQPAPTFAEQSTTSEILVTGIKVIDLLAPYSKGGKIGLFGGAGVGKTVLIMELINNIAKVHSGYSVFAGVGERTREGNDLYHEMIESGVIKIDNLSESKVALVYGQMNEPPGARARVALTGLTLAEQFRDQSGTDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGALQERITSTKAGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRAISELGIYPAVDPLDSTSRILDPQIVGEEHYNVARAVQGILQRYKSLQDIIAILGMDELSEEDKLSVARARKIQRFLSQPFDVAKVFTGSDGVQVPLEKTIASFKAVVNGEYDHLPEAAFYMVGDIEDVIAKAQRLAAQAA
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
A3PIB9
Q2U9B5
KAE1_ASPOR
tRNA threonylcarbamoyladenosine biosynthesis protein kae1
Aspergillus subgen. Circumdati
MIAIGLEGSANKLGVGIMLHPDNGNPPQVLANIRHTYVSPPGEGFLPKDTARHHRAWVVKLVKKALKEAHVSVQDVDCICFTKGPGMGAPLQSVAVAARMLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVDLPYTVKGMDCSFSGILAAVDGLATTYGLGGEGKDDETDTPIPDADGNGKPTRADLCFSLQETIFSMLVETTERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAGLLAYSTGFRTPLKDSTCTQRFRTDDVFVKWRD
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Q2U9B5
Q9PK65
EX7L_CHLMU
Exodeoxyribonuclease VII large subunit
Chlamydia
MSITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRRPKDGDYVILHGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSRRCHQFQVILYPVTVQGPTAAQEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETDFTLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKKHLATADFYHTAQQTLDYTRLSLERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLNQALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHAKHLLNQLSRRLHFVMANSQETKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVIISAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q9PK65
P14083
LOV_DROME
Tyrosine kinase-related
Sophophora
MLKDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPATPPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPPGGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVSMDEDCKSVGSKQSSSVDEDYSGPGIPLSLEHRREISATGPPLTPSNGGTGHD
Has a regulatory role during midline cell development.
P14083
B1LF98
LSRF_ECOSM
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
Escherichia
MADLDDIKDGKDFRTDQPQQNIPFTLKGCGALDWGMQSRLSRIFNSKTGKTVMLAFDHGYFQGPTTGLERIDISIAPLFEHADVLMCTRGILRSVVPPATNKPVVLRASGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQLVDAGMKVGMPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIKTYYVDKGFERIVAGCPVPIVIAGGKKLPEREALEMCWQAIDQGASGVDMGRNIFQSDHPVAMMKAVQAVVHHNETADRAYELYLSEKQ
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
B1LF98
Q72PK6
SYT_LEPIC
Threonyl-tRNA synthetase
Leptospira
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEVLTYSEKLGWETFQHSAAHLLGMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPEDFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKYKIEIIDGIPSEEVSIYGMGEWFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIEEAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPAVLSSELWKKSGHWDNFHENMYFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAEFGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEVMDIIDFTFTVYKKFGFSEFKTFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRLWQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWISPNQIRILTVTEKVTDYAKNVYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILGEKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Q72PK6
B4E8E6
PAND_BURCJ
Aspartate 1-decarboxylase alpha chain
Burkholderia cepacia complex
MQRHMLKSKIHRAAVTHCELHYEGSCAIDEDLLEAAGLIENERIDIWNINNGERFSTYAIKGERGSGMISLNGSAARRAQLGDLVIIAAFAMVDEAELQAGWKPKLVFIDEGNKIKGHRDHVPTQNWT
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
B4E8E6
B3PXB0
UREE_RHIE6
Urease accessory protein UreE
Rhizobium
MQRVTSYLPAGTPSSHPTAQVKLPHDLRHLRRKLLHLENGEMVMLDLKDPVLFANGDLLVREDGELIEILAADEKLFEIRGRDRTHLVELAWHLGNRHLAAQIEEDRIVILRDHVIRNMLQGLGATVLEINEPFQPARGAYHSHGGHSHDHGHAAHDHGHAAHDHGHNHDHDHGHAHGHDHQHDHNCDHDHDHGHHHGHKHD
Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
B3PXB0
Q7Z3Y8
K1C27_HUMAN
Type I inner root sheath-specific keratin-K25irs3
Homo
MSVRFSSTSRRLGSCGGTGSVRLSSGGAGFGAGNTCGVPGIGSGFSCAFGGSSSAGGYGGGLGGGSASCAAFTGNEHGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDELKNQIISATTSNAHVVLQNDNARLTADDFRLKFENELALHQSVEADINGLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELIEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIDGEDGSCSKSKGYGGPGNQTKDSSKTTIVKTVVEEIDPRGKVLSSRVHTVEEKSTKVNNKNEQRVSS
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
Q7Z3Y8
Q9AMS6
PAND_BRADU
Aspartate 1-decarboxylase alpha chain
Bradyrhizobium
MQITLMKGKIHRASVTEADLHYEGSISIDRTLLEAAGMVINERVEIYNVETGTRFATYVIEAPPMSGTMSLNGAAARLVMPGDKIIIVAYASFDEAEAKKFKPHVVRVDRDNRILAS
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Q9AMS6
Q033H5
PTH_LACLS
Peptidyl-tRNA hydrolase
Lactococcus cremoris subsp. cremoris
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLANELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRAVAPLLKYYNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVVNHVLSGFDNEDKEIAQDGIFKAVDAMKFYLENGDFQKTMNKFN
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Q033H5
Q311P4
THIG_OLEA2
Thiazole synthase
Oleidesulfovibrio
MEHTTTHNNDPLVLGGRALESRLFIGTGKYGSDSLIPRVAEASGAQVITVALRRVDMQAAAGNVMQHIPQHMQLLPNTSGARTAEEAVRIARLARAAGCGDWIKIEVISDSRYLLPDGYETAKATEILARDGFVVLPYMNPDLYVARDLVSAGAAAVMPLGAPIGTNRGLRTQEMIGILIEEIELPVIVDAGIGRPSQACEAMEMGAAACLVNTAIASAGDPVLMASAFGAAVRAGRRAWLAGTGAVLEGQAQASSPLLGFLDS
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Q311P4
A3PEX6
RS20_PROM0
30S ribosomal protein S20
Prochlorococcus
MANNKSAKKRIQIAERNRLINKSYKSTVRTLTKKTLENCEKYKKEPNDENKNLVTTSLNKAFSLIDKAVKKNVLHKNNGANRKSKINNFVKTTLTTK
Binds directly to 16S ribosomal RNA.
A3PEX6
P33919
RADD_ECOLI
Putative DNA repair helicase RadD
Escherichia
MIFTLRPYQQEAVDATLNHFRRHKTPAVIVLPTGAGKSLVIAELARLARGRVLVLAHVKELVAQNHAKYQALGLEADIFAAGLKRKESHGKVVFGSVQSVARNLDAFQGEFSLLIVDECHRIGDDEESQYQQILTHLTKVNPHLRLLGLTATPFRLGKGWIYQFHYHGMVRGDEKALFRDCIYELPLRYMIKHGYLTPPERLDMPVVQYDFSRLQAQSNGLFSEADLNRELKKQQRITPHIISQIMEFAATRKGVMIFAATVEHAKEIVGLLPAEDAALITGDTPGAERDVLIENFKAQRFRYLVNVAVLTTGFDAPHVDLIAILRPTESVSLYQQIVGRGLRLAPGKTDCLILDYAGNPHDLYAPEVGTPKGKSDNVPVQVFCPACGFANTFWGKTTADGTLIEHFGRRCQGWFEDDDGHREQCDFRFRFKNCPQCNAENDIAARRCRECDTVLVDPDDMLKAALRLKDALVLRCSGMSLQHGHDEKGEWLKITYYDEDGADVSERFRLQTPAQRTAFEQLFIRPHTRTPGIPLRWITAADILAQQALLRHPDFVVARMKGQYWQVREKVFDYEGRFRLAHELRG
RadD contains helicase motifs, suggesting it may be a helicase, although that activity has not been observed (Probable). In combination with RadA is important in repair of double-strand DNA breaks (DSB) . Has DNA-independent ATPase activity that is stimulated by single-stranded DNA-binding protein SSB. ATPase is stimulated by a peptide with the last 10 residues of SSB, but not when the peptide's last Phe residue is missing. Binds ssDNA; binding is slightly better in the presence of nucleotides . May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds to DNA structures with 3 branches that resemble replication forks .
P33919
Q8X878
KEFB_ECO57
K(+)/H(+) antiporter
Escherichia
MEGSDFLLAGVLFLFAAVAAVPLASRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAALLAGLLMLTDFAWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPLLAGSADEHFDWMKIGMKVLAFVGMLIGGRYLLRPVFRFIAASGVREVFTAATLLLVLGSALFMDALGLSMALGTFIAGVLLAESEYRHELETAIDPFKGLLLGLFFISVGMSLNLGVLYTHLLWVVISVVVLVAVKILVLYLLARLYGVRSSERMQFAGVLSQGGEFAFVLFSTASSQRLFQGDQMALLLVTVTLSMMTTPLLMKLVDKWLSRQFNGPEEEDEKPWVNDDKPQVIVVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQVDLLRSAGAEAAESIVITCNEPEDTMKLVEICQQHFPHLHILARARGRVEAHELLQAGVTQFSRETFSSALELGRKTLVTLGMHPHQAQRAQLHFRRLDMRMLRELIPMHADTVQISRAREARRELEEIFQREMQQERR
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
Q8X878
A7NAH6
GCST_FRATF
Glycine cleavage system T protein
Francisella
MLKTPLYESHIAANAKMIDFSGWSMPINYGSQIQEHNNVREDCGIFDVSHMLAVDIQGSEAEKFLRYLLANDVAKLQENKAQYGCMLNHDAGIVDDLITYKVTDEHFRIVVNAGNRESDVAWFNQNAQNFDVAITPQTDLAIVAVQGPKAVAVIKRVVTKEIAAEIEALLPFSFKFFSKWMVARTGYTGEDGFEVILPATQVKKFWDSLLENGAQPAGLGARDTLRLEAGMHLYGADMDTSTTPLERGLGWSVDLSDEHRDFIGKKAYLAKKAQGVDTKWVGVVLKTKGVLRAGQEIDFDNGEKGYITSGSFSPTLKVAIGLAYVPKQADNPVVNIRGKELEVELVKPKFVKNGKSLI
The glycine cleavage system catalyzes the degradation of glycine.
A7NAH6
Q2SWD4
HISZ_BURTA
ATP phosphoribosyltransferase regulatory subunit
pseudomallei group
MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLAGLKKIRLDLCHAGVLAALFARDAAAAGRGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDEARRQLPALPEIARALDDLAHLASQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVVEPR
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Q2SWD4
Q9C1B5
TRI10_FUSSP
Core trichothecene cluster (CTC) protein 10
Fusarium
MEFPKPRQFRETSLLMYYLDVVFPLQYISPNNNCLGKREWLLTILTSARPTYYATLCLALLYKESLSTSCRSEQTLVWKREKTYYYILALQESQKLLGGLNKTFGITRLKGTVVALACMLQLIGFESSHLSRGDWRVHLLAANTLIPVLAEGWSTALQSGPPATSIWCELDESDFDSIDDQTSLSFEYLGALRFLSNSLAKIGILSCISVGPAAPFEDYGHLLDQPGLIQLEEVLGCKNWAMLTILEVGKLDRWKRQEQEHNRLSLKTLAMRAMIIEDMLTDELQKLPTSETLPDLITHIYAASIATYLHTVVSGLNPNLSEVQDSVCATILLLERLPDLQAVASVTWPLAVTGCMASESHKDFFRSTLRSYEATFSSLKKYDGVLEVLEDAWKKREVDTESPMRWEDLMDHHGLPVLLF
Transcriptional activator of all of the trichothecene biosynthesis genes . Acts upstream of the cluster-encoded transcription factor TRI6 and is necessary for full expression of both the other trichothecene genes and the genes for the primary metabolic pathway that precedes the trichothecene biosynthetic pathway .
Q9C1B5
A6UYJ0
THIG_PSEA7
Thiazole synthase
Pseudomonas
MSQASSTDTPFVIAGRTYGSRLLVGTGKYKDLDETRRAIEASGAEIVTVAVRRTNIGQNPGEPNLLDVIPPDRYTILPNTAGCYDAVEAVRTCRLARELLDGHNLVKLEVLADQKTLFPNVVETLKAAEQLVKDGFDVMVYTSDDPIIARQLAEIGCIAVMPLAGLIGSGLGICNPYNLRIILEEAKVPVLVDAGVGTASDAAIAMELGCEAVLMNTAIAHARDPVMMAEAMKHAIVAGRLAYLAGRMPRKLYASASSPLDGLID
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
A6UYJ0
P0A2C6
RBSB_SALTI
Ribose import binding protein RbsB
Salmonella
MNMKKLATLVSAVALSATVSANAMAKDTIALVISTLNNPFFVSLKDGAQKEADKLGYNLVVLDSQNNPAKELANVQDLTVRGTKILLINPTDSDAVGNAVKMANQAKIPVITLDRQATKGDVVSHIASDNVLGGKIAGDYIAKKAGEGAKVIELQGIAGTSAARERGEGFQQAVAAHKFNVLASQPADFDRTKGLNVMQNLLTAHPDVQAVFAQNDEMALGALRALQTAGKADVMVVGFDGTPDGEKAVKDGKLAATIAQLPDQIGAKGVEVADKVLKGEKVQAKYPVDLKLVIKQ
Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
P0A2C6
E7D082
SCX5B_MESEU
MeuNaTxalpha-5b
Mesobuthus
MNYLILISFALLVITGVESARDAYIAKPHNCVYECFDAFSSYCNGVCTKNGAKSGYCQILGTYGNGCWCIALPDNVPIRIPGKCHRR
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=790 nM) and drosophila DmNav1 (EC(50)=280 nM) . The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels . Has antimicrobial activity (Ref.2).
E7D082
Q7VEJ7
GRPE_PROMA
HSP-70 cofactor
Prochlorococcus
MKEEVSTSNQEDLVADQEVIASEESDLSPKEEKVSESTIDDDDSLNDAELQSNKQTLDNEARLEQLEKEHETLRSQYVRIAADFDNFRKRQSRDQDDLKLQLTCNTLSEILPVVDNFERARQQINPEGEEALTIHRNYQNLYKQLVDVLKKLGVAPMRVVGQSFDPTLHEALLREPSELMVEDMILEELVRGYHLNGRVLRHAQVKVSMGPGPKVDEEDKQIDEDSQADKRDEATTASNELD
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Q7VEJ7
Q4JXU4
GCSH_CORJK
Glycine cleavage system H protein
Corynebacterium
MTALPTDFLYSEEHEWVNTSAVVEGETVRVGITHIAAEALGDIVFVELPEVGSEVEAGEAFGEVESTKSVSDIYAPVSGEVVAVNEALEDNAGLINEDPYGEGWLYEVKVTEAGELMEAEAYQAANE
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Q4JXU4
A0A3Q7HRZ6
MYC2_SOLLC
bHLH transcription factor bHLH147
Solanum subgen. Lycopersicon
MTEYSLPTMNLWNNSTSDDNVSMMEAFMSSDLSFWATNNSTSAAVVGVNSNLPHASSNTPSVFAPSSSTSASTLSAAATVDASKSMPFFNQETLQQRLQALIDGARETWTYAIFWQSSVVDFSSPSVLGWGDGYYKGEEDKAKRKLSVSSPAYIAEQEHRKKVLRELNSLISGAPPGTDDAVDEEVTDTEWFFLISMTQSFVNGSGLPGQALYSSSPIWVAGTEKLAASHCERVRQAQGFGLQTIVCIPSANGVVELGSTELIVQSSDLMNKVRVLFNFSNDLGSGSWAVQPESDPSALWLTDPSSSGMEVRESLNTVQTNSVPSSNSNKQIAYGNENNHPSGNGQSCYNQQQQKNPPQQQTQGFFTRELNFSEFGFDGSSNRNGNSSVSCKPESGEILNFGDSTKKSASSANVNLFTGQSQFGAGEENNNKNKKRSATSRGSNEEGMLSFVSGTVLPSSGMKSGGGGGEDSEHSDLEASVVKEADSSRVVEPEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLQNTESDKEDLKSQIEDLKKESRRPGPPPPPNQDLKMSSHTGGKIVDVDIDVKIIGWDAMIRIQCNKKNHPAARLMAALMELDLDVHHASVSVVNDLMIQQATVKMGSRHYTEEQLRVALTSKIAETH
Transcriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 . Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth . Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) . Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter . Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses . Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA . With JA2L forms a transcription module that regulates wounding-responsive genes . With ERF.C3 forms a transcription module that regulates pathogen-responsive genes . Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection . Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) . Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling . May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels .
A0A3Q7HRZ6
O32143
XDHE_BACSU
Probable xanthine dehydrogenase subunit E
Bacillus
MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQLTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAFLEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRIRRELNGGRRESGF
Oxidizes hypoxanthine and xanthine to uric acid.
O32143
Q88M07
SERC_PSEPK
Phosphohydroxythreonine aminotransferase
Pseudomonas
MSKRAFNFCAGPAALPDAVLQRAQAEMLDWRGKGLSVMEMSHRSDDYVAIAEKAEQDLRDLLSVPSNYKVLFLQGGASQQFAEIPLNLLPENGTADYIETGIWSKKAIEEARRFGNVNVAATAKPYDYLAIPGQNEWNLTKNAAYVHYASNETIGGLQFDWVPQTGDVPLVVDMSSDILSRPIDVSQFGLIYAGAQKNIGPSGLVVVIVREDLLGHARSSCPTMLDYKVSADNGSMYNTPATYSWYLSGLVFEWLKEQGGVEAMEQRNRAKKDRLYGFIDRSEFYTNPISVNARSWMNVPFRLADERLDKAFLAGADARGLLNLKGHRSVGGMRASIYNALGLEAVEALVGYMAEFEKEHG
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Q88M07