accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
P32113
COPA_ENTHA
Probable copper-importing P-type ATPase A
Enterococcus
MATNTKMETFVITGMTCANCSARIEKELNEQPGVMSATVNLATEKASVKYTDTTTERLIKSVENIGYGAILYDEAHKQKIAEEKQTYLRKMKFDLIFSAILTLPLMLAMIAMMLGSHGPIVSFFHLSLVQLLFALPVQFYVGWRFYKGAYHALKTKAPNMDVLVAIGTSAAFALSIYNGFFPSHSHDLYFESSSMIITLILLGKYLEHTAKSKTGDAIKQMMSLQTKTAQVLRDGKEETIAIDEVMIDDILVIRPGEQVPTDGRIIAGTSALDESMLTGESVPVEKKEKDMVFGGTINTNGLIQIQVSQIGKDTVLAQIIQMVEDAQGSKAPIQQIADKISGIFVPIVLFLALVTLLVTGWLTKDWQLALLHSVSVLVIACPCALGLATPTAIMVGTGVGAHNGILIKGGEALEGAAHLNSIILDKTGTITQGRPEVTDVIGPKEIISLFYSLEHASEHPLGKAIVAYGAKVGAKTQPITDFVAHPGAGISGTINGVHYFAGTRKRLAEMNLSFDEFQEQALELEQAGKTVMFLANEEQVLGMIAVADQIKEDAKQAIEQLQQKGVDVFMVTGDNQRAAQAIGKQVGIDSDHIFAEVLPEEKANYVEKLQKAGKKVGMVGDGINDAPALALADVGIAMGSGTDIAMETADVTLMNSHLTSINQMISLSAATLKKIKQNLFWAFIYNTIGIPFAAFGFLNPIIAGGAMAFSSISVLLNSLSLNRKTIK
Probably involved in copper import under copper limiting conditions.
P32113
Q987S0
KATG_RHILO
Peroxidase/catalase
Mesorhizobium
MDAKTDDNSAGKCPVAHGSAGRTNRDWWPNQLNVQILHQQSSLSDPMGEAFDYAEEFKSLDLDAVIKDLHALMTDSQEWWPADFGHYGPLFIRMAWHSAGTYRIADGRGGAGAGQQRFAPLNSWPDNVNLDKARRLLWPIKQKYGRKISWADLLILTGNVALESMGFKTFGFAGGRADVWEPEQDVYWGPEGKWLADERYSGDRDLQNPLGAVQMGLIYVNPEGPNGNPDPLAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGDASLVGVEPEGADIEQQGLGWASKFGTGKGGDAIGSGLEVIWTTTPTKWSNNFFDNLFGFDWELTKSPAGAHQWTPKGGAGAGTVPDAHNSAKRHAPSMLTTDLALRFDPSYATISKRFHENPDQFADAFARAWYKLTHRDMGPVARYLGPLVPKEELPWQDVIPVVDHVLIDEQDAEALKAEILASGLSVSQLVSTAWASASTFRGSDKRGGANGARIRLSPQKDWAVNQPAELAKVLDKLQAIAKDFNAAQTGSKKVSLADLIVLGGNAGIEKAAKAAGHSVDVPFWPGRMDASQEQTDIHSFAPLEPTVDGFRNYVSGKQRLTVEEALVDRAQLLTLTAPELTVLVGGLRVLGANAGQSKHGVFTKQPETLSNDFFVNLLDMGTEWKATSDAKDVFEGRDRKTGEVKWTGTRADLIFGSHSQLRALAEVYATADAKAKFAKDFVVAWTKVMNADRFDIAG
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Q987S0
Q9LFX9
PTR13_ARATH
Nitrate transporter 1.6
Arabidopsis
MGVVENRKILPEKKLGGWRAITFILGNETLEKLGSIGVSANFMLYLRNVFHMEPVEAFNVYYLWMGLTNFAPLLGALISDAYIGRFKTIAYASLFSILGLMTVTLTACLPQLHPPPCNNPHPDECDDPNKLQLGILFLGLGFLSIGSGGIRPCSIPFGVDQFDQRTEQGLKGVASFFNWYYLTLTMVLIFSHTVVVYLQTVSWVIGFSIPTSLMACAVVLFFVGMRFYVYVKPEGSVFSGIARVIVAARKKRDLKISLVDDGTEEYYEPPVKPGVLSKLPLTDQFKFLDKAAVILDGDLTSEGVPANKWRLCSIQEVEEVKCLIRVVPVWSAGIISIVAMTTQATFMVFQATKMDRHMGPHFEIPAASITVISYITIGIWVPIYEHLLVPFLWRMRKFRVTLLQRMGIGIVFAILSMFTAGFVEGVRRTRATEMTQMSVFWLALPLILMGLCESFNFIGLIEFFNSQFPEHMRSIANSLFPLSFAAANYLSSLLVTTVHKVSGTKDHPDWLNKDLDRGKLDYFYYLIAVLGVVNLVYFWYCAHRYQYKAGSQIEDFNEEKSLLDIEPNQRHDQSPS
Low-affinity proton-dependent nitrate transporter. Not involved in dipeptides transport. Involved in delivering nitrate for seed development.
Q9LFX9
A5VP09
DXS_BRUO2
1-deoxyxylulose-5-phosphate synthase
Brucella
MSRPSTPLLDKVPTPDRLRALPERDLPQLAEELRTELIDAVSTTGGHLGAGLGVVELTVALHHVFNTPYDRIIWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRAESEYDPFGAAHSSTSISAGLGMAVASELSGEKRNVIAVIGDGSMSAGMAYEAMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLVSGRTYRSVREAAKQVAQKLPKFLQDKARKSEEYARAFFTGGTLFEELGFYYVGPIDGHNLDHLLPVLKNVRDTQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGKQAKPPANAPSYTKIFGTSLIEEARHDDKIVAVTAAMPTGTGLDLFGEAFPKRVFDVGIAEQHAVTFAAGLASEGYKPFCAIYSTFLQRGYDQVVHDVSIQNLPVRFPIDRAGLVGADGPTHAGSFDTGFLAALPGFVVMAASDEAELRHMVRTAAEYDEGPISFRYPRGDGVGVDLPERGSVLEIGKGRIVREGTKVALLSFGTRLQECLAAAEELGAAGLSTTVVDARFAKPLDHDLIRRLAREHEVLVMVEEGAVGGFGSHVLQFLATDGLLDRGLKVRALTLPDIYQDHGKPDAMYAEAGLDRTGIVRTVFAALHRDELGHEALPTPFRA
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
A5VP09
Q8IX95
CTGE3_HUMAN
Putative cTAGE family member 3
Homo
MTFKGFQMNEEKLEIGIQDASSENCQLQESQKQLLQEAEVWKEQVSELNKQKITFEDSKVHAEQVLNDKENHIETLTERLLKIKDQAAVLEEDITDDGNLELEMNSELKDGAYLDNPPKGALKKLIHAAKLNASLTTLEGERNQFIFSYLKLIKPGRA
Tumor-associated antigen.
Q8IX95
Q7V1T7
HEM1_PROMP
Glutamyl-tRNA reductase
Prochlorococcus
MHIVVVGLSHRTAPVEVREKLSIPDQSISESLKTLSINSDILEVSILSTCNRLEIYALVKEINIGISSIKEFLTDYSSVNFEDLNPHLFDFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLSQSVSAGKKVRSETNLGTGAVSISSAAVELAQLKIGQDHGVDGLVSLKSEKVLVVGAGRMSRLLITHLKSKGCNRLTLLNRNIERAVNLAGDFPDLEINCKSLNELDKNISLSSLVFTSTASEKPFIDLARVEKISLNNKLKFIDIGVPRNISNDVKHHAFIESFDVDDLEEVVSRNQEFRQKIAKEAESLVKDERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSRDERQASLKIVEKLFSLVDDE
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Q7V1T7
Q4UKS2
LEPA_RICFE
Ribosomal back-translocase LepA
spotted fever group
MNNQKYIRNFSIIAHIDHGKSTLADRLIEHCGGLQAREMSQQVLDSMDIEKERGITIKAQTVRLVYKAKDGNTYYLNLMDTPGHVDFAYEVSRSLAACEGSLLVVDSTQGVEAQTLANVYQAIENDHEIVPVLNKIDLPASEPEQVKQQIKDIIGIDASEAVLISAKSGIGIDLVLEAIVNKLPPPKESSSDILKALLVDSWYDPYLGVVILVRIIDGTLRKNIRIKMMATNSVYTVENVGYFTPKKHISDVLHAGEIGFFTASIKQVADCKVGDTITDEKKPCEQALPGFKPNLPVVFCGLYPTDSAEFEHLKDSLAKLRLNDASFEYEMESSSALGVGFRCGFLGLLHLEIIQERLSREFDLDLITTAPSVVYKIHMRDGESLEIHNPADLSDLQKIESMEEPWIKATIMVPDEFLGAVLSLCTEKRGVQLDHSYIANRAKIIYKLPLNEIVYDFYDRLKSCSKGYASFEWQMDVYEPSELVKLGILVNGEEVDALSTIVHRSRAEQRGRALCVRLKDLIPRQQIDIAIQASIGSRIIARETIKALRKDVLSKCYGGDISRKRKLLEKQKAGKKRMRQYGNIEIPQSAFIAALKIGDE
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
Q4UKS2
B9KSH8
ISPD_CERSK
MEP cytidylyltransferase
Cereibacter
MTTAAIIVAAGRGTRAGGDLPKQWQPLAGRPVLAHTLAAFRAAAGVSRTLLVIHPDDRARAEALPGVAEGKVELVEGGASRDASVRNALEALAGAGIERVLIHDGARPLVAPGLIARTLAALESAPGAAPAVPVSDALWRGEGGRVVGTQDRTGLFRAQTPQAFRYEAILAAHRAHPGGAADDVEVARAAGLEVAIVEGCEDNLKVTYPGDFARAERLLALAAGL
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
B9KSH8
A4SV71
MRAY_POLAQ
UDP-MurNAc-pentapeptide phosphotransferase
Polynucleobacter
MLLILAQWLQDDFGFFRVFNYITFRAVMATVTALLIGLAAGPWVIRKLSELKMGQAVRTDGPLTHLVKSGTPTMGGVLILIGIFVSCMLWADLSNRFIWIVMIVTFGFGAVGWVDDYRKVVRKDPKGMASREKFFWQTLIGLFAAIYLAFSVSEINNLKVLELFFEWVKSGFALDLPAKTNLLLPFMKEVSYPLGMMGFIILSYLVIVGSSNAVNLTDGLDGLVIMPVILVGAALGAFAYVMGNAIYAKYLLFPYIPGAGELMIFCGAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTIAVIVRQEIVLFVMGGIFVAETVSVMMQVVWFKITKKHFGEGRRIFRMAPLHHHFELGGWKETQVVVRFWIITILLVLIGLSSLKLR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
A4SV71
Q0S0L4
METK_RHOJR
Methionine adenosyltransferase
Rhodococcus
MSQSGSRLFTSESVTEGHPDKICDAISDSILDALLTDDPRARVAVETLVTTGQVHVAGEVTTSAYADIPKIVRDTVLEIGYDSSAKGFDGNSCGVNVAIGAQSPEIAQGVDHSHEVRTGELSDDEIDRQGAGDQGLMFGFATTDTPELMPLPIALAHRLSRRLTEVRKSGVLPYLRPDGKTQVTIEYDGDKAVRLDTVVISTQHAADIDLDNLLTPDLREKVLGSVLAEIDMPELDVSDIRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNAVAAGLADRIEVQVAYAIGKAAPVGLFVETFGTEKTDPARIQQAITETFDLRPGAIIRDLDLLRPIYAQTAAYGHFGRTDIDLPWESIDRAEKLRAAAGL
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Q0S0L4
Q3YWV4
RL6_SHISS
50S ribosomal protein L6
Shigella
MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGVDKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q3YWV4
A7GK22
RL23_BACCN
50S ribosomal protein L23
Bacillus cereus group
MRDPRDIIKRPVITERSMEMMAEKKYTFDVDVKANKTEVKDAVEAIFGVEVEKVNIMNYKPKAKRVGRHAGFTNRRRKAIVKLTADSKEIEIFQGV
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
A7GK22
A5WI20
DNAK_PSYWF
Heat shock protein 70
Psychrobacter
MAKTIGIDLGTTNSCVAVMEGDKVKVIENAEGTRTTPSIIAYKDGEILVGQSAKRQAVTNPNNTLYAIKRLIGRRFDDKVVQKDIGMVPYKIVKADNGDAWVEVNDKKMAPPQISAEILQKMKKTAEDYLGEKVTDAVVTVPAYFNDSQRQATKDAGKIAGLNVKRIINEPTAAALAYGMDKKKGDSTVAVYDLGGGTFDVSIIEIADVDGEQQFEVLSTNGDTFLGGEDFDLALIDYLVEEFKKEQNFNLKGDPLAMQRLKEAAEKAKIELSSAQSTEVNLPYITADASGPKHLVVTISRSKLEALTEALVKRTIDPCKVALEDAGLKASDIDDVILVGGQTRMPLVQKTVEEFFGQEPRKDVNPDEAVAVGAAIQGAVLSGDKTDVLLLDVTPLTLGIETMGGVMTGIIEKNTMIPTKKSQVFSTAEDNQPAVTIKVFQGERKVAAQNKLLGEFNLTDIPPAPRGMPQIEVTFDINADGIMNISAKDKGTGKEQSIQIKADSGLSDEEIEQMVRDAEANAAEDEKFAALAQVRNEADGRIHAIQKALKDAEDKVTEEEKSSVETAISDLELAAKEDDHDDIKAKLEALDNAFLPISQKIYAAGQGAEGAAPQADATEANAADDDVVDAEFTEVNEDDKK
Acts as a chaperone.
A5WI20
P05023
AT1A1_HUMAN
Sodium pump subunit alpha-1
Homo
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
P05023
A6VMY7
AROC_ACTSZ
5-enolpyruvylshikimate-3-phosphate phospholyase
Actinobacillus
MAGNSIGQLFRVTTFGESHGIALGCIVDGVPPNMALSEADIQPDLDRRKPGTSRYTTARREADEIQILSGVFEGKTTGTSIGLIIKNADQRSKDYGDIMDKFRPGHADYTYQQKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLRERFGIEIRGYLSQIGEVKIDPQTVADVTKINWQQVADNPFFCPDKSAVEKFDELIRKLKKEGNSIGAKLTVVAENVPVGLGEPVFDRLDAELAHALMGINAVKAVEIGDGFDVVAQKGTEHRDEMTPAGFLSNHAGGILGGISNGQPIIATIALKPTSSITIPGRTVDINNKPVELITKGRHDPCVGIRAVPIAEAMVAIILLDHLLRFKAQCK
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
A6VMY7
A7RG82
CLP1_NEMVE
Protein CLP1 homolog
Nematostella
MDTEQDAKSEERQQWKLEKDTELRVEVAEGDREAIIVLLSGNAEVFGTELVKNKKFTFRPGSKLAIFTWQGCSVEIQGPLEVAYKSKETPMVMYLNLHMALEQMRERADKHEAVELGPRVMVVGPTDVGKSTVCQLLLNYAVRMGRRPISVDLDVGQGTASVPGSMGALLLERPADIEEGFSLQAPLVYLFGHTSPSPNEKLYNMLSSKIADIVFQRFERNKKACASGCVINTCGWVTGMGYRIIVHAATAFKVNVIVVLDQERLYNDLKNQFGDKVQIVHLPKSGGVVVRSRETRRKVRDERLRSYFYGQQANLYPHSFEVKFSDVKLFKIGAPLVPDSCLPLGMDQGQNETKLVPVVPTKDLKHCLLAISAAESLEEDLVQTNVIGFLVVNEVDLDREVMVVLSPAPRPLPRKFLLLSEIKFMDFK
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
A7RG82
Q8R857
ACPS_CALS4
4'-phosphopantetheinyl transferase AcpS
Caldanaerobacter
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSKVLGTGIRGFSWQDIEIIHNEYGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAIAVGGENS
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
Q8R857
Q91YY2
B4GT3_MOUSE
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
Mus
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPAAPGAAGAPPAQALPYCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRSPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPRGSH
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Q91YY2
Q8ZXL4
NADE_PYRAE
NH(3)-dependent NAD(+) synthetase
Pyrobaculum
MFVYDVVNALDYEKARSIITAFISQYVQRAGSRGVVVGISGGVDSTVAAALAVEALGRQRVLGLLMPSLYTPPEDLKDALDVINALGVEWKRVDITPIYDAFVKTLPDFSQENRVAAGNILPRIRMTVLYYYANKYNLLVMGTGDRSELLLGYFTKYGDGGVDFLPIGSLFKLQVRELAARLGFADIAKKPSSPRLWQGHTAEGELGASYEVIDQVLYAVFDLKKPPEEVRGFFGEVVDIVITRVKKNIHKLTPPAYPDITPARRNV
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Q8ZXL4
A8IM96
RUVC_AZOC5
Holliday junction resolvase RuvC
Azorhizobium
MTNGMIRIIGLDPGLRRTGWGVIEAQGTRLTYVACGTILPPENAPMAERLAELHRGLAEVLARHAPDEAAVEETFVNMNPSSTLKLGQARGVVMLAPAQAGLSVAEYAPLLVKKTVVGAGRAEKAQIRMMIGVLLPKATPQTEDAADALAVAVTHAHHRGPAALRRAAL
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
A8IM96
Q9H4I8
SEHL2_HUMAN
Serine hydrolase-like protein 2
Homo
MSENAAPGLISELKLAVPWGHIAAKAWGSLQGPPVLCLHGWLDNASSFDRLIPLLPQDFYYVAMDFGGHGLSSHYSPGVPYYLQTFVSEIRRVVAALKWNRFSILGHSFGGVVGGMFFCTFPEMVDKLILLDTPLFLLESDEMENLLTYKRRAIEHVLQVEASQEPSHVFSLKQLLQRLLKSNSHLSEECGELLLQRGTTKVATGLVLNRDQRLAWAENSIDFISRELCAHSIRKLQAHVLLIKAVHGYFDSRQNYSEKESLSFMIDTMKSTLKEQFQFVEVPGNHCVHMSEPQHVASIISSFLQCTHMLPAQL
Probable serine hydrolase. May be related to cell muscle hypertrophy.
Q9H4I8
Q0BKM8
MURD_FRATO
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Francisella
MFSFYFNDNKITKLLMVGYGSTGKSVCDFLANFIDITVDISQNDDEFVNYDLNSYDLITVSPGIPLNKSPYRALTKFKDKIVSDIDIFYQYIKDTKAKTIAVTGSNGKSTVVTMTDFVLKDLGYKSILVGNIGTPALNKIGEKFDYCVVEVSSFQINLFNCVRFDLGCIINVSPDHLDRYQNFEQYKQSKLNLAKFSNDFFVYDVHNGIKYAGEYQIIRGAIYRNSTKLLDIVETKLFGEHNLENIIVVLNILDRLGLDINQAIDSIKKFKGLEHRCKIVKKVNGTTYINDSKGTNVGATIAALNSITNSKNIILLLGGVAKGGDFSLMIKSLDKYVKYVYIYGADKEYIESYIKGYCKYQLCNNMKQAFELASQKANSNEIVLLSPACASFDEFSGYAQRGEVFQNLVAQLEQKS
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q0BKM8
P00318
APCB_MASLA
Allophycocyanin beta chain
Mastigocladus
MQDAITAVINSSDVQGKYLDTAALEKLKSYFSTGELRVRAATTIAANAAAIVKEAVAKSLLYSDITRPGGNMYTTRRYAACIRDLDYYLRYATYAMLAGDPSILDERVLNGLKETYNSLGVPISATVQAIQAMKEVTASLVGPDAGKEMGVYFDYICSGLS
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. Allophycocyanin has a maximum absorption at approximately 650 nanometers.
P00318
A6US28
KAE1B_METVS
Serine/threonine-protein kinase Bud32
Methanococcus
MGNSNELICIGLEGTAEKTGVGVITSNGEVLFNKTVIYTPKIQGIHPREAADHHAETFIKLLNEVSGVIPLDKIDLVSFSQGPGLGPSLRVTATTGRALALSLKKPIIGVNHCVSHVEIGKLKTDALDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIAIGNCLDQFARYCNLSHPGGVFVEQYAKEGKKFLKLPYTVKGMDISFSGLLTASMKKYDSNEKIEDVCYSLQETAFSMLTEITERALSHTNKPEIMLVGGVAANDRLKEMLEIMCNEQNVDFYVPEKQFCGDNGAMIAWLGILQYINGKRMDILDTKTIPHFRTDMVDVNWVVKSTENELDILNKKRQIPRHLIGKGAEADILKGRYLEWESITKERIKKGYRTAELDEMIRTRRTVKEARFLSIIKDFSVNSPHIFDIDIENKKITMEYIHGKLLKDLIEEGNLEFCKSIGELIGKMHEGKIIHNDLTTSNFIVNTDAYMIDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFGEIWDKIIEGYSKYGHSELVLQYIKEVEKRGRYL
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.
A6US28
Q9KCM0
RHAB_HALH5
Rhamnulose kinase
Halalkalibacterium (ex Joshi et al. 2022)
MNYSLAVDIGASSGRLIVGECNKKIQLTEIHRFENQIIEKNGQFCWDVDALFSEIKTGLKKCREAGIEPVSMGIDTWAVDFVLLDEHDKPLTDAVSYRDPRTDGVMEEVIEQFMKERLYLETGIQFQQFNTIYQLYALKKQHPDIFKKAKSFLMIPDYFHFLLTGKKANEYTNATTTQLVNAFTKKWDKDIIEALGFNPDMFQEIKLPTESLGKLKSEWVEEVGFDLEVILPATHDTGSAVVAVPKVADTIYLSSGTWSLIGVENSFPICVTKALDYNFTNEGGMNYQFRFLKNIMGLWMIQEVRRNYDNRYSFAQLVELSKGISFKSTVDVNDPRFLKPTNMIKEIQRYCQETGQQAPELPGEVAKCVFESLAESYTSAVAEIEDIFEKDFKSINVIGGGCRNELLNQLIADRTKKDVFAGPIEATAIGNLVAQWMALGEIESIQQARKLIYDSFDVKRYVSADRE
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
Q9KCM0
Q4QK81
TTCA_HAEI8
tRNA 2-thiocytidine biosynthesis protein TtcA
Haemophilus
MTQLAQQEKKQTYNFNKLQKRLRRNVGNAITDFGMIEDGDKVMVCLSGGKDSYTLLDILLNLQQNAPIKFDIVAVNLDQKQPGFPEHVLPEYLESIGVDYKIVQENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLATLFLNMFYGGKMKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAIAKEFPIIPCNLCGSQPNLQRQVVKEMLNTWDRQYPGRLETMFSAMQNITLSHMCDPKLFDFKGIKHGQLIDGIEGDTAFDEEKITPMQFEDEDQTDFSNNEMINFKEVN
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
Q4QK81
F7J187
NVD2_CIOIN
Neverland 2
Ciona
MLIEYLIRITVMVITSERLLILMGLCDESFHFPVMIRVVFNAAVAIVIALVMSKLYKVLFAPLDLRRKLEDVGYVHHDHSVSREENIRDTQRRKKLGNTPPVFPNGWFKVADSTWIKKGQVKSIYFFGEQLALFRNKRGLLRALDAYCPHLLANMAAGGKVVNSDCLECPFHGWKFSGETGKLVDVPYAQKVPTFVSVKKWSCCEVDGMAYLWYHCDGGEPKWVLPSSVTINTLKYAGKTEHIINSHIQDIPENAADISHLDHLHKPVIGSDVEKTNESLLNNLIFHSIQASWKPPTDPNEPHRSTMSIKDNIHLSIFNIKIPLLYLEFEIDQIGPGAVHIHVRTPFFRGLMLQNVTPIEPFVQKLTHSFYVSPWVPVCIAKAFYLLETTQIERDILMWNNKTYFRQPVLVKEESALAKHRRWYQQFYSENSPRMNHRGDLVYPGKPKLADW
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
F7J187
O69717
VPB50_MYCTU
Putative antitoxin VapB50
Mycobacterium tuberculosis complex
MTSLLEVLGAPEVSVCGNAGQPMTLPEPVRDALYNVVLALSQGKGISLVPRHLKLTTQEAADLLNISRPTLVRLLEDGRIPFEKPGRHRRVSLDALLEYQQETRSNRRAALGELSRDALGELQAALAEKK
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50.
O69717
A1KSN6
HIS6_NEIMF
ImGP synthase subunit HisF
Neisseria
MALAKRIIPCLDVKDGRVVKGVNFIGLRDAGDPVEAAKRYNGEGADELTFLDITASSDNRDTILHIIEEVAGQVFIPLTVGGGVRTVADIRRLLNAGADKVSINTAAVTRPDLIDEAAGFFGSQAIVAAVDAKAVNSENTRWEIFTHGGRNPTGLDAVEWAIEMQKRGAGEILLTGMDRDGTKQGFNLPLTRAVAEAVDIPVIASGGVGNVRHLIEGITEGKADAVLAAGIFHFGEIAIREAKRAMREAGIEVRL
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A1KSN6
Q0DJA3
DRB3_ORYSJ
dsRNA-binding protein 3
Oryza sativa
MKKKSAPTPLPPETANTSPAPIGATAGIRVENCYVFKSRLQEYAQKAGLQTPEYHTSKEGPSHEPVFKSTVVINNTSYGSLPGFSNRKAAEQSAAEVALMEIVKSIPANANIPAVQETGLCKNLLQEYAQKMNYAIPSYICTKPASGLAPFLCTVEIGGIQYIGAAARTKKDAEIKAARTALLAIQGQSEGSANGATKYIVVPGKRVGKEVEKRPIETPKPLKAKKGGFKKKWNKRKFMKKDGQAVDVEKDEARVAGDAHDSDVLMQPTVITQEASCGTLFLQPCEEAKRVEDEPPRDIEMVQPDKENQHSDAALVQPDDEARVEQEPSRDISVVQPNEEAISAKQEPSIDAATLQPKEEAMKTGCVALVLCLNISVDPPDVIKISPCVRKECWIDPFSMAAPKALETIGKTLHSQYERWQPKARYKLQLDPTLEEV
Binds double-stranded RNA.
Q0DJA3
Q8F4I2
DDL_LEPIN
D-alanylalanine synthetase
Leptospira
MAKIAVFFGGSSTEHSISILTGCFICKTLHTMGHSVKPILLTKDGGWVVPSEYRMSIPFEVSNSPDLFQEEFQKRYGVSRTNQIFSLDADIVFLGLHGGQGEDGTIQGFLEILGIPYTGSGVLASAIAMDKTRANQIFLQSGQKVAPFFEIDKLEYLNSTDAVITKLETLGFPQFLKPVEGGSSVSVYKITNREQLKEKLALIFESDSKVMSQSFLTGIEVSCGVLERYRDGKFKKIALPATEIVPGGEFFDFESKYKQGGSHEITPARISEQEMKRVQELAIAAHRSLGCSGYSRTDFIIVNGEPHILETNTLPGMTETSLIPQQAKAAGISMEEVFSDLIEIGLKRSLY
Cell wall formation.
Q8F4I2
Q9M2S0
GMPP2_ARATH
Probable mannose-1-phosphate guanylyltransferase 2
Arabidopsis
MKALILVGGFGTRLRPLTLSLPKPLVDFANKPMILHQIEALKAIGVDEVVLAINYEPEQLLVMSKFSNDVEATLGIKITCSQETEPLGTAGPLALARDKLVDGSGQPFFVLNSDVISDYPLEEMIAFHNAHGGEASIMVTKVDEPSKYGVVVMEEATGRVERFVEKPKLFVGNKINAGIYLLNPSVLDRIELRPTSIEKEIFPQIAEAEKLYAMLLPGFWMDIGQPRDYITGLRLYLDSLRKKSPSKLATGPHILGNVLVDETAEIGEGCLIGPNVAIGPGCVVESGVRLSHCTVMRGVHVKRYACISSSIIGWHSTVGQWARVENMSILGKNVYVCDEIYCNGGVVLHNKEIKSDILKPDIVM
Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.
Q9M2S0
B5YJH1
PYRDB_THEYD
Orotate reductase (NADH)
Thermodesulfovibrio
MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRIYETPCGMINSIGLQNIGLEAFKKEKLPFLKKFNTNIIVNFFGENLDEYIEVAKLLDETEGVHALEMNVSCPNKTSEWRKMGLEPELLREAIKRVRLHIKKPLIVKLAPQVTEIALMARICEEEGADAVSLINTIPAMVIDIKTRKSMIGTLTGGLSGPAIRPVALRAVWEVAQAVKIPVIGVGGIVSAEDALQFLIAGAKAIQVGTANFINPIATVEIIEGIKQFLIEENIKDINEIIGSFKE
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
B5YJH1
B4SBU9
RL23_PELPB
50S ribosomal protein L23
Pelodictyon
MINPLLRPLLTEKSTGLTEKKGQYVFVVKPDADKTDIKKAVEKKFGVEVKSIRTINCLGKSRAQNTRKGRVTGKKSDWKKAIITLEKGQSIDYYSNTAQKSEG
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
B4SBU9
Q04557
HYIN1_AGRVS
Indole-3-acetamide hydrolase
Agrobacterium
MVEISSISQTLRALRRKQYSCRDLVESLVSRSESATHLNAFAATDWLHLRNEADRVDRNGSGGVGLMGIPLCFKANIATGIFPTSAGTQGLLRHKPAIPAKIVERLHSAGALIGASGNMHELSFGITNDNKTFGPARNPWNQALISGGSSGGVAVSVAANLMLGGIGTDTGASVRLPAALCGVVGFRPTFGNYPTDGIVPVSPSRDTPGLIVRSVEDAVLLDRIIRNKCPTQNMSLKGLRLGLPRSHFFDNLEPHVAAASERAIRRLATNQMTFVEADIPNVAELTRKVSLPVAIYEFPRALMAYLSFHGIGNTFDELIQNIQDPQVYDLVQSQLSKGLISESVYRRALRCYKPRLKATYENYYSSNGLDAVLFPSVPLTAKPVGLQTTLVHNGVETDTFGIFVRNLDPSSNIGLPSLSVPVSLTPDRLPVGIQIEGPFGSDDMVLAIGRAVEEMVKFGQEY
Hydrolyzes indole-3-acetamide (IAM) into indole-3-acetic acid (IAA).
Q04557
B2FPX7
RECO_STRMK
null
Stenotrophomonas maltophilia group
MMIEDDTGFVLHARAYRETSLLVEVLSAQHGRVGLLARGVSTAKGQVLRAALQPLQWIRFSAQQRGELAQLRGAEALDAAPRLVGQAMLAGFYLSELTLRLAPRQDPLPELYLAYGEARARLAVGAGLAWTLRRFERELLTALGLGFELDSASDGQPIDPAARYELDPQEGAQRLLSERGGERRAAATGSALLALAADEEPAAADLASLRLPMRRVLAHHLGPRGLKSWEMLEQLAPRR
Involved in DNA repair and RecF pathway recombination.
B2FPX7
Q5QQX7
CP19A_CANLF
Estrogen synthase
Canis
MLLEMLNPMHYNITSMMPEVMPVATMPILLLTGFLLLVWNYEDTSSIPGPGYCMGIGPLISHCRFLWMGIGSACNYYNKMYGEFMRVWICGEETLIISKSSSMFHIMKHSHYSSRFGSKLGLQCIGMHENGIIFNNNPTLWKAIRPFFTKALSGPGLVRMVTVCVGSIITHLDRLEEVSNELGYVDVLTLMRRIMLDTSNILFLGIPLDESAIVVKIQGYFDAWQALLLKPDIFFKISWLYKKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDHMDFATELIFAEKRGDLTRENVNQCILEMLIAAPDTMSVSVFFMLFLIAKHPKVEESIMKEIQAVVGERDIRIDDMQKLKVVENFIYESMRYQPVVNLVMRKALQDDIIDGYLVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLRRFHVQTLQGECIENMQKKYGLSLHPDETNNLLEMVFVPRNSEKCLER
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Q5QQX7
B7UKK1
LPXH_ECO27
UDP-2,3-diacylglucosamine diphosphatase
Escherichia
MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHHQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVNAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
B7UKK1
Q48HY8
ARNE_PSE14
Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE
Pseudomonas
MTWLMLLSACLLTCLGQIAQKYAVEGWRETFPGVLAALRSMWLWLAIACLGLGLLVWLLVLQRMDVGIAYPMLGLNFVLITLVGRYVFKEPVDPQHWLGIALILVGVFQLGRQA
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
Q48HY8
O24407
IAA16_ARATH
Indoleacetic acid-induced protein 16
Arabidopsis
MINFEATELRLGLPGGNHGGEMAGKNNGKRGFSETVDLKLNLSSTAMDSVSKVDLENMKEKVVKPPAKAQVVGWPPVRSFRKNVMSGQKPTTGDATEGNDKTSGSSGATSSASACATVAYVKVSMDGAPYLRKIDLKLYKTYQDLSNALSKMFSSFTIGNYGPQGMKDFMNESKLIDLLNGSDYVPTYEDKDGDWMLVGDVPWEMFVDSCKRIRIMKGSEAIGLAPRALEKCKNRS
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
O24407
O33950
CATA2_ACILW
CDI2
Acinetobacter
MNKQAIDALLQKINDSAINEGNPRTKQIVNRIVRDLFYTIEDLDVQPDEFWTALNYLGDAGRSGELGLLAAGLGFEHFLDLRMDEAEAKAGVEGGTPRTIEGPLYVAGAPVSDGHARLDDGTDPGQTLVMRGRVFGEDGKPLANALVEVWHANHLGNYSYFDKSQPAFNLRRSIRTDAEGKYSFRSVVPVGYSVPPQGQTQLLLDQLGRHGHRPAHIHFFVSAPGFRKLTTQINIDGDPYLWDDFAFATRDGLVPAVRQAEVRKANRTAWTVSSR
Can cleave 4-methyl-, 4-chloro-, and 3-methoxycatechol at lower rates than catechol, but has no activity with 4-nitrocatechol or protocatechuic acid.
O33950
Q9S714
PSAE2_ARATH
Photosystem I reaction center subunit IV B, chloroplastic
Arabidopsis
MAMTSAATGFILTANVPAAIGGGSSKSTTIVSFLPMRSFGSRLVVRAAEDTPPATASSDSSSTTAAAAPAKVPAAKAKPPPIGPKRGSKVKILRKESYWYKNVGSVVAVDQDPKTRYPVVVRFAKVNYANISTNNYALDEVEEVK
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
Q9S714
Q1I7D4
FADB_PSEE4
3-hydroxyacyl-CoA dehydrogenase
Pseudomonas
MIYEGKAITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSSGKDVFIVGADITEFVDNFKLPEAELVAGNLEANRIFSDFEDLEVPTVAAINGIALGGGLEMCLAADYRIMSSSAKIGLPEVKLGIYPGFGGTVRLPRLIGSDNAIEWIAAGKENRAEDALKVGAVDAVVAPELLQAGALDLIKRAISGELDHKAKRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFAKLARTSVAESLIGLFLNDQELKRKAKAHDEIAHDVKQAAVLGAGIMGGGIAYQSAVKGTPILMKDIREEAIQLGLNEASKLLGKRVEKGRLTPAKMAEALNAIRPTLSYGDFGNVDIVVEAVVENPKVKQAVLAEVEGQVKEDAILASNTSTISINLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSEVAVATTVAYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAVDALYEANRLGQKNGKGFYAYETDKRGKPKKVADASVLDVLKPVIFEQREVSDEDIINWMMVPLCLETVRCLEDGIVETAAEADMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADKYADLGPLYHATAKLREMAKNGQRFFN
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Q1I7D4
O35594
IFT81_MOUSE
Carnitine deficiency-associated protein expressed in ventricle 1
Mus
MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAEIDPKQDVDIREEMPEQTAKRMLNLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRSNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKECEQLKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYMVTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELETKVNEVNTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVLVKTNQTREFDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVIKELRQLRQKCQELTQECDEKKAQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHYTNCMIKNLEVELRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKAVRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL
May play a role in development of the testis and spermatogenesis.
O35594
Q2G8X7
RL2_NOVAD
50S ribosomal protein L2
Novosphingobium
MALKSYNPTSPARRGLVLVDKSALWKGKPVKALTEGKRKTGGRNNKGHVTSRGIAGGHKQKYRYVDFKRRKWDMPATVERLEYDPNRTAFIALVKYEDGELAYILAPQRLGVGDQVIAGEKTDVKPGNAMLLSQMPVGTIIHNVEMKPGKGGQIARSAGTYVQLVGRDRGMVIVRLNSGEQRYLRGDCMGTVGAVSNPDNGNQNLAKAGRNRWLGKRPLTRGVAKNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGARTRHNKATDKMIIRSRHAKKKR
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Q2G8X7
C6C3U9
ZAPC_MUSP7
Cell division protein ZapC
Musicola
MKLIPDDNWRWYFDADQARLMLDLANGMTFRSRFSATMLTPDAFNPSDFCVEDAALFFTYQEKCLTLNIDAQAKAELVLNALVANRFLKPLMPKSWHFAALGHGEYCPQLGELVWVRLNERLEDACFMVVDTGDKASLCLLAQAELALSGKVMVLGEAIKIMHDRLCPVDEGADHAQSSLHFAHAG
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
C6C3U9
P13659
MBEB_ECOLX
Mobilization protein MbeB
Escherichia
MSNLLQTGAEFEKKLKERAESTEKMLNNEFRRLGESVSEAVTSNETKIRDAIALFTASTEESLEKHREGVKEAMMQHRRDVLKLAGNTGMMLLGIVFLLFTASGGTLWYLGGRIQANLEEIRKQEETLQKLNAKTWGVEFVQDGNRKFLVLPYGKSAEVIPFQGKEWVHLKE
This protein is essential to promote the specific transfer of the plasmid in the presence of conjugative plasmids.
P13659
P57688
KDPC_THEAC
Potassium-translocating ATPase C chain
Thermoplasma
MKSYLKALVFAVLFLFILGFVYPTVTSLITEHALPFQSEGQPVEIDGHIYGSYLLAEAFNSSFFFHPRPSAIDYNLSESGSYDYSLGNPAMLNLTEKYLHRFLSENPGVNISEIPYAMISYSGSGLDPGIPLQGAIIQIPRISIAIHNITNLSVSDLYSYLYNLVNSTKTQNFPFFGSYYVNVVRLNVDIVEFLLKGGYISQSQI
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
P57688
Q21MS9
PDXA_SACD2
4-(phosphohydroxy)-L-threonine dehydrogenase
Saccharophagus
MSHPAIIALTPGEPAGIGPDLTVMAAQQARDYPLVALCDPQLLKDRAKLLGLPLTVSTYIQGSAVTTSAQHISVMPIPLGAPCEAGTLDSTNAAYVIETLKQATEGCLSGEFAAVVTGPVQKSVINEAGINFSGHTEYFADNSNTPRVVMMLATEGLRVALATTHLPLKDVSAAITTASLTETLNILLADLQLKFGLSQPRVLVCGLNPHAGEGGHLGMEEIDTIIPVLEQFRARGHNLVGPLPADTLFNPKYLSDADAVLAMYHDQGLPVLKYKGFGNAVNITLGLPFIRTSVDHGTALDLAGTGKANIGSLQVALGYAQNLAMQQASINEIAG
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
Q21MS9
P18834
COL14_CAEEL
Cuticle collagen 14
Caenorhabditis
MAKRARLRLILLAKLVSLKMSDEKEKRSLRPVAFVAVVFSTVAITSCLITFPLILHYIQTLESQVQLDLEFCQARARDMWKEMLDIETGGKKDSAKLANIVLNHRRLEKRDTLQDFWARRLHDQELRDQPVGYDNPSVGVESFNSEGGGCCTCHRGPPGPAGDGGRDGADGVDGTPGEIGPPGPPAPPGPDPHSLFPPQCPCEAPPGDGGPPGQPGPDGPPGAPGNAGEDGKPGDQGPRGPPGIPGAPGQPGRPGPPGEPGTYKTEVGPAGRAGAPGRPGPPGQPGPAGPPGENGKGGGQGPSGLPGPPGQPGQNGAPGEVGQPGDNGAPGSCDHCPPARLAPGY
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
P18834
B5Y341
RSGA_KLEP3
Small ribosomal subunit biogenesis GTPase RsgA
Klebsiella
MSKNKLSKGQQRRVNANHQRRLKTTAEKADYDDNLFGETSEGIVISRFGMHADVESADGSVHRCNIRRTIRSLVTGDRVVWRPGKDAADGVNVKGIVEAVHERASVLTRPDFYDGVKPIAANIDQIVVVSAILPELSLNIIDRYLVACEAQDIEPLIVLNKIDLLDDDGLRFVNEQMDIYRNIGYRVLMVSSRTQDGLKPLEAALTDRISIFAGQSGVGKSSLLNALLGLNEDQILTNDVSDVSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEAEQITHGFVEFHDYLGHCKYRDCKHDNDPGCALREAVENGKIAESRFENYHRILESMEQVQVKTRKNFSSSDD
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
B5Y341
B1J1X7
GMHA_PSEPW
Sedoheptulose 7-phosphate isomerase
Pseudomonas
MDMQSRIRRLFQASIDTKQQAMDILAPHIEQASLVMVNALLNEGKMLACGNGGSAGDAQHFSSELLNRFERERPSLPAIALTTDSSTLTSIANDYSYNEIFSKQIRALGQPGDVLLAISTSGNSANVIQAIQAAHDREMIVVALTGRDGGGMASLLLPEDVEIRVPSTVTARIQEVHLLAIHCLCDLIDSQLFGSEE
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
B1J1X7
Q84RF2
OPF17_ARATH
Ovate family protein 17
Arabidopsis
MRVKATLINFKSKLSKSCNRFVSLFRFRVKRPVFIRPLRARHGNVKPRHQHHHSKKPICSCLCFLNSSKNHKMSNAKHRSSSFSVNDDDYSKFMQSPLTPATAKKLFTSPITTPYSSRTRKSLNARDTFEDNAVEDACRSFENYLIHLIVEEGKIDDLMDIEELLFCWKNLKSPVFIELVSRFYGELCRDLFSGE
Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Q84RF2
Q7U4J7
RL2_PARMW
50S ribosomal protein L2
Parasynechococcus marenigrum
MAIRNFRPYTPGTRTRVVTDFSEVTGRKPERSLVVSKHRRKGRNNRGVITCRHRGGGHKRLYRVVDFRRNKHGITAKVAAIHYDPHRNARLALLFYADGEKRYILAPAGVQVGQTVVSGPDAPIENGNAMPLSAVPLGSSVHCVELYAGRGGQMVRTAGASAQVMAKEGDYVALKLPSTEVRLVRRECYATLGEVGNSEVRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHGGGEGRAPIGRSGPVTPWGKPALGLKTRKRNKPSNRYVLRKRRKTSKRSRGGRDS
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Q7U4J7
Q4VZH2
NDHJ_CUCSA
NADH-plastoquinone oxidoreductase subunit J
Cucumis
MQGNLSSWLVKHGLVHRSLGFDYQGIETLQIKPEEWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGIDQPEEVCIKVFAARINPRIPSVFWVWKSADFPERESYDMLGIYYDNHPRLKRILMPESWVGWPLRKDYIAPNFYEIQDAH
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Q4VZH2
Q6MHJ5
PIF1_BDEBA
ATP-dependent DNA helicase pif1
Bdellovibrio
MNSESKCYRFYICFARLGSGMIAGLMPVHEIELSPEQASALDLLRSGENVFLTGGAGSGKSFLIRQFMRELDPKEMPILASTGAAAVLLGGRTFHSFFGLGIMEGGADATYERASKDKRLMSRLRKVEGVIIDEISMIPGQALMIAEALSQRARESKLPWGGMRVIAVGDFAQLPPVTHTGQRDWCFLNGVWEVSGFQTVMLSHNQRVSDNLFLDVLSDVRHGKVTERVREFLNEHVQDHDEDDPGTRLFPRKINAEKFNERKLAEIDETEVVIESIYSGSERHIETLKKASPIAEKLILKIGCQVMFLQNDPQRRWVNGTRGTVVDITADQITVRKDRGREVQVSKSSFAIQDAEGNIMAQVEQFPLTLAYATTIHKSQGATLDDLWCDLSQLWEPGQAYVALSRLRSAKGLHLIGWNPRSIIVDPKVLHFYKQFEGL
DNA-dependent ATPase and 5'-3' DNA helicase that efficiently unwinds G-quadruplex (G4) DNA structures. May be involved in resolving commom issues that arise during DNA replication, recombination, and repair.
Q6MHJ5
P41732
TSN7_HUMAN
Transmembrane 4 superfamily member 2
Homo
MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV
May be involved in cell proliferation and cell motility.
P41732
A9WSE6
RUVC_RENSM
Holliday junction resolvase RuvC
Renibacterium
MRVFGVDPGLTRCGFGVVDVAANRSASLVAVGVIGSSSELPLSQRLLVISESIDQWLDTHSPDVLAVERVFSQTNLSTVMGVAQASGIVIAAAAKRGIAVALHTPSEVKAAVTGNGRADKIAVTAMVTRILKLKVAPTPADAADALALAITHAWRSGPGSTAAAGELTPARKLWLEAEAKARKNVEKSSKQRR
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
A9WSE6
Q02548
PAX5_HUMAN
B-cell-specific transcription factor
Homo
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH
(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription . Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity .
Q02548
A5GTY4
PSBA1_SYNR3
Photosystem II Q(B) protein 1
unclassified Synechococcus
MQTTIQQRSGASAWQQFCEWVTSTDNRLYVGWFGVLMIPTLLAATTCFIVAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPFQLVIFHFLIGIYAYMGREWELSYRLGMRPWICIAYSAPVAAASAVFLVYPFGQGSFSDAMPLGISGTFNYMLVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTESESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGVSTMAFNLNGFNFNQSILDSQGRVLNTWADILNRAGLGMEVMHERNAHNFPLDLAAAESAPVALQAPAIG
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
A5GTY4
Q9UTC3
PSF3_SCHPO
DNA replication complex GINS protein psf3
Schizosaccharomyces
MDYYDIDSILSENQKVPCTSTVSIPGLGHEGRMVPTGSKVELPFWLAEVLAINSFVSIHMPAPFSSVVRNALKANPNSVSIRDITTHYYHFAEKMLHLISDDSLVQISLNTLRSRAMLIADASLNPQGALQQNSQFIEGLDDFEKHILRVSHNAHRSLINWQNSTS
The GINS complex plays an essential role in the initiation of DNA replication.
Q9UTC3
B7V5C7
UBID_PSEA8
Polyprenyl p-hydroxybenzoate decarboxylase
Pseudomonas
MTFKDLRDFIAQLEQRGALKRIQVPISPVLEMTEVCDRTLRAKGPALLFEKPTGFDMPVLGNLFGTPERVALGMGAEDVGALREIGKLLAQLKEPEPPKGLKDAWAKLPMYRKVLSMAPKVLKDAPCQEVVEEGEDVDLGRLPVQTCWPGDVGPLITWGLTVTRGPNKERQNLGIYRQQVIGRNKVIMRWLSHRGGALDYREWCQKHPGQPYPVAVALGADPATILGAVTPVPDTLSEYAFAGLLRGHRTELVKCRGSDLQVPASAEIVLEGVIHPGEMADEGPYGDHTGYYNEVDRFPVFTVERVTRRQKPIYHSTYTGRPPDEPAILGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMLGVWSFLRQFMYTKFVIVTDDDIDARDWNDVIWAITTRMDPKRDTVMIDNTPIDYLDFASPVSGLGSKMGLDATHKWPGETSREWGRAIVKDEAVTRRIDALWSSLGID
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
B7V5C7
A4VTL1
SEPF_STRSY
Cell division protein SepF
Streptococcus
MALKDTFKNLFNYFEVDEVNEVEEQADAYSMPNDRPKMRVANTTVAPVREQQPKVETRREARSESQLQRLHERQQELMTNNNEKEIVKTTIDIKFPKRYEDAPEMVNLLLDNASILIDFQYMSEQQARRCLDYLDGARSVLSGNLKKVSNTMWLLTPVNVTVNIEELRNAGTTTGVADSNFEFDIKR
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
A4VTL1
O88413
TULP3_MOUSE
Tubby-like protein 3
Mus
MEAARCAPGPRGDSAFDDETLRLRQLKLDNQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMPRSDVILHGIDGPAAFLKPEAQDLESKPQVLSVGSPAPEEGTEGSADGESPEETAPKPDLQEILQKHGILSSVNYDEEPDKEEDEGGNLSSPSARSEESAAASQKAASETGASGVTAQQGDAQLGEVENLEDFAYSPAPRGVTVKCKVTRDKKGMDRGLFPTYYMHLEREENRKIFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLRSNLMGTKFTVYDHGVNPVKAQGLVEKAHTRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNEHESLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPLCALQAFAIGLSSFDSKLACE
Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.
O88413
D2Z025
DCSB_STRLA
hydroxyarginase
Streptomyces
MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDDWSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREHPDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQAVLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWDVLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSERAEQAVAVILDMVAPAFDAAAARP
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the hydrolysis of N(omega)-hydroxy-L-arginine (NHA) to yield hydroxyurea (HU) and L-ornithine.
D2Z025
Q5ZM55
FEM1B_CHICK
FEM1-beta
Gallus
MEGLAGYVYKAASEGRVLTLAALLLNRSESDIKYLLGYVSQHGGQRSTPLIIAARNGHTKVVRLLLEHYRVQTQQTGTVRFDGFVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQHADPNAKAHCGATALHFAAEAGHLEIVRELVKWKAAMMVNGHGMTPLKVAAESCKADVVELLLAHAGCNRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERYRDSENIIEKEVLPPIEAYGNRTECRTPQELESIRQDRDALHMEGLIVRERILGSDNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNEPVKAKDIESVLRCSVLEIEQGMSRIKATQDDDIHTAVDNYECNIFTFLYLVCISTKTQCSEEDQSRINKQIYNLIHLDPRTRDGSTLLHHAVNSSTPVDDFHTNDVCSFPNALVTKLLLDCGADVNAVDNEGNSPLHLIVQYHRPISDFLTLHSIIISLVEAGAHTDMTNKQKKTPLDKSTTGVSEILLKTQMKLSLKCLAARAVRIYNISYQNQIPRTLEEFVKFH
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, leading to their ubiquitination and degradation.
Q5ZM55
Q8WHM7
MATK_SPIIN
Intron maturase
Spirodela
MEEFKGYLQKGGFKQQHFLYPLLFQEYIYVLAHDHGLNVNASTLNEPSEISGYDNKSSLLLVKRLITRIYQQNSLIHSVNDSNQNRFVGHNNNFYYKMISEGFAIVVEIPFSLRLISSLKEKKEIPKSQNLRSIHSIFSFLEDKFAHLNYVSDILIPYPVHLEILVQILQCWIQDVPSLHLLRFLFHEYHNGNNCITPKKSSYGFSKDNPRLYRFLYNSYVVECESIFVFLRKSSSYLQSTSFGTLLERTYFYGKIKHIGVTHSNDFQKTLWLFKDPFMHYVRYQGKSIMASKGTHLLMKKWKSYFVNLWQCHFHFWSQPSRIHINQFSHFSFYFLGYLSSVPINRSSVKSQMLENSFLIDTVTKKFETMVSIIPMIGSLSKAKFCNLSGNPISKPVWADLSDSDIIDRFGRICRNLSHYYSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRAFLQRLGSEFLEEFFMEEEKVLSLMLPRTSYSLHKLYREPIWYLDIIRINDLVNHL
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q8WHM7
B8EBJ3
RL5_SHEB2
50S ribosomal protein L5
Shewanella
MAKLHDKYQETVVAELAKKFGYTSVMQVPRIEKITLNMGVGEAVADKKIMDHAVRDMTAIAGQKPVVTVARKSVAGFKIREGYPIGCKVTLRGERMWEFLERLVDIAIPRIRDFRGLSAKAFDGRGNYAMGVREQIIFPEIDYDKIDKIRGMDIVITTTAKNDEEGRALLDAFNFPFKK
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
B8EBJ3
A1SME0
CLPX_NOCSJ
ATP-dependent Clp protease ATP-binding subunit ClpX
Nocardioides
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELSEGAEVSLDELPKPKEIFEFLNSYVIGQEQAKKSLAVAVYNHYKRVQAGLQPMSGKHSKEEVVEVAKSNILVIGPTGCGKTYLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKAENPSITRDVSGEGVQQALLKIIEGTTASVPPQGGRKHPHQEFIQIDTTNILFVVGGAFAGLEHIIEQRVGKKTLGFTAEVRGKAEREAEDLLAQVRPEDLTKFGLIPEFIGRLPLIASVSKLDQEALVQILTEPRNALVKQYQKLFELDGVELEFTPDAIEAIADNALERGTGARGLRAIIEEVLLHVMYDVPSRGDIAKVIVTREVVMDGVSPTLIPRESEKKKKSA
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
A1SME0
P45167
UUPL_HAEIN
ATP-binding protein Uup-like
Haemophilus
MEAIEWLENFLLDFQGSIVFISHDRSVIRKMATRIVDLDRGQLQSYLGNYDLYLTTKEENLRVEALQNELFDKRLAQEDVWIRQGIKARRTRNEGRVRALKAMREERRQRREVMGTAKLQLDTSSRSGKIVFEMEDVSYEIAGKTLLKDFSTTILRGDKIALVGPNGCGKTTFIKLLLGEIQPTSGKIRCGTKLEIAYFDQYRADLDPEKIVMDNVADGKQDIEINGVKRHVLGYLQEFLFPPKRAMTPVKALSGGERNRLLLAKLLLKPNNLLILDEPTNDLDVETLELLEEILTDYQGTLLIVSHDRQFIDNTATECYLFEGEGRLNKYVGGFFDAKQQQANFWASKAVEEQAKAKKSEPLKEESAVKNDRTSKPKSVKLSYKEQRELEQLPQLLEELETKITTLQAEIADPAFFQQAHDITDAKLKALADTEAELETAFLRWEELEEKKNLADGKA
Might play a role in ribosome assembly or function; this is missing the first ABC transporter domain compared to paralogs.
P45167
A5U036
RL10_MYCTA
50S ribosomal protein L10
Mycobacterium tuberculosis complex
MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLTGSATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKALVIKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLARLAAALQEKKACPGPDSAE
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
A5U036
I0B6F5
CYC8_CHACT
Cyclotide chaC8
Chassalia
MAKFANYLMLFLLVASLVMLEAQSSDTIKAPDWGKRLLMNHDSDLGAIPCGESCVWIPCISTVIGCSCSNKVCYR
Probably participates in a plant defense mechanism (Probable). Active against E.coli ATTC25922 but not against S.aureus ATCC 12600 or S.epidermidis ATCC 14990 . Has cytotoxic and hemolytic activity .
I0B6F5
Q9HKT2
LPLAC_THEAC
Lipoate--protein ligase subunit 2
Thermoplasma
MVLNYTMHMMYSKNWKAKKGLIRVTLDLDGNRIKDIHISGDFFMFPEDSINRLEDMLRGSSIEKINDIIRDFYNQGVITPGVEPEDFIQALRVI
Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.
Q9HKT2
F1S5L4
GPAT1_PIG
Glycerol-3-phosphate acyltransferase 1, mitochondrial
Sus
MDESALTLGTIDVSYLPNSSEYSIGRCKHASEEWGECGFRPPVFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDRFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKKILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATEMNLPLIFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGQKDILYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNTIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSAPLSLEQALLPAILPSRPSDAVDEGTDMSINESRNAADESFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCITITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLKKRGSGGPASPSLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQICHETVGRFIQYGILTVAEQDDQEDISPSLAEQHWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFIHNFSGPVPEPEYLQKLHKYLINRTERRVAVYAESATYCLVKNAVKMFKDIGVFKETKQKKVSVLELSSTFLPQCNRQKLLEYILSFVVL
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
F1S5L4
Q9XIC5
NAC17_ARATH
Protein REGULATORS OF AOX1A 2
Arabidopsis
MADSSPDSCFKGGKFSAPGFRFHPTDEELVMYYLKRKICRKRLRVNVIGVVDVYKMDPEELPGQSMLKTGDRQWFYFTPRSRKYPNAARSNRGTENGYWKATGKDRVIEYNSRSVGLKKTLVFYRGRAPSGERTDWVMHEYTMDEDELGRCKNPQEYYALYKLFKKSGAGPKNGEQYGAPFQEEEWVDDDNEDVNAIAVAVPEQPVVRYEDARRVDERRLFNPVILQLEDIDELLNGIPNAPGVPQRCIPQVNSEEELQSTLVNNSAREFLPNGQQYNRPSSFDSLETAEVTSAPLVFEKEDFIEMDDLLLIPEFGASSTEKAAQFSNHGEFDDFNEFDQLFHDVSMSLDMEPIDQGTSANLSSLSDSANYTSDQKQQLLYQQFQDQTPENQLNNIMDPSTTLNQITSDIWFEDDQAILFDQQQSFSGAFASPSSGVMPDSTNPTMSVNAQGHEIQNGGGTTSQFSSALWALMDSIPSTPASACEGPLNRTFVRMSSFSRMRFNGKANGTPVSTTIAKKGIRNRGFLLLSIVGALCAIFWVLVATVRVSGRSLLLKD
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling.
Q9XIC5
A0JZA2
RL1_ARTS2
50S ribosomal protein L1
Arthrobacter
MAKRSKAYEAAAAKIDAEKFYAPFEAVTLAKDTNPSKFDATVEVAFRLGVDPRKADQMVRGTVNLPHGTGKVARVLVFATGDKAEAAIAAGADFVGSDDLIEKIAAGWTDFDAAVATPDLMGKVGRLGKVLGPRNLMPNPKTGTVTPDVTKAVNDIKGGKIDFRVDKHSNLHFIIGKVSFDAIKLAENYAAALEEVLRLKPSASKGRYIQKATVATTFGPGISVDPNVTKVLTEV
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A0JZA2
A9WH80
RS8_CHLAA
30S ribosomal protein S8
Chloroflexus
MSVNDPIGDMLTRIRNACMARHTTVSMPASNMKEAIARILKREGFIRDYAVIDDGKSHKTITITLKYLPDRRPAITGLRRVSKPGLRIYTKRTDIPRVRGGLGLCILSTPKGVLADHEAWRERVGGEVLCYVW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A9WH80
Q65VU4
NQRA_MANSM
NQR-1 subunit A
Basfia
MITIKKGLDLPINGKPEQVIRDGNAVTEVALLGEEYVGMRPSMKIHEGDTVKKGQILFEDKKNPGVVFTAPVSGTVTAINRGAKRVLQSVVIRVEGNDQETFAKYSPAELVSLSSEQVRQNLQTSGLWTALRTRPLSKIPAVDAVPSSIFVNAMDTNPLCADPAVIINEYQADFTNGLTVLTRLHNKVNLCKAAGSNIASVDNVDSHEFAGVHPAGLVGTHIHFIDPVGINKSVWHINYQDVIAIGKLFTTGELFTDRVVALAGPQVKNPRLVRTNIGANLSQLTANELADGNNRVISGSVLYGAKAEGAHDYLGRYALQVSVIAEDTEKEFFGWISPQANKYSITRTVLGHFGRKLFNFTTAENGGHRAMVPIGSYERVMPLDILPTLLLRDLEVGDTDSAQALGALELDEEDLALCTFVCPGKADYGSFLRQALDKIEKEG
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Q65VU4
Q9JZ38
CLPP_NEIMB
Endopeptidase Clp
Neisseria
MSFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENPDKDIFFYINSPGGSVTAGMSIYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALPNSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLMAKHCDRDLADLERDTDRDNFMSAEEAKEYGLIDQILENRASLRL
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q9JZ38
C0Q0Y1
SYM_SALPC
Methionyl-tRNA synthetase
Salmonella
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSADQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSHFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLKHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLAAELADPQLYKTFTDAAAVIGEAWESREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERVEAFLNSELNWDAIEQPLLSHKVNTFKALYNRIDMKQVEALVEASKEEVKAAAAPVTGPLADFPIQETITFDDFAKIDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSSYPDPQALIGRQTVMVANLAPRKMRFGVSEGMVMAAGPGGKDIFLLSPDDGAKPGQQVK
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
C0Q0Y1
C8V7P3
IVOC_EMENI
Ivory mutation-related protein C
Aspergillus subgen. Nidulantes
MLSLDLVFSFPAWALLLVLTLLYTLYLATTRLLLSPIRHIPGPTLAALSFWPEFYYDVVQRGQYFRQIDKMHQTYGPLVRINPFEIHIQDPSFYPVLYTGPTRRRHKWLWAARMFGNNTSAFATVRHEHHRLRRSALNPLFSKSAIQRLTPHLQHTLARLCSRLDGFAFTRQDVDLGIGLTAFAADVITEYCFGQSLELIGKDNFGKEWIDMVSAPSELGHLVKQCPWILVVCKWAPKALVRALLPGVALLFQIQERMSAQIQPLVDRAAAVDKPADPLTVFDFLLSSTLPQHEKTVDRLKGEGQTLIGAGTLTTGNALKTIIFHVLNDPDIFRKLRAEVDGALENMDILSMSDTAYLERLPYLSACIKEGLRISYGVTHRLQLIAEEPLIYSGVTIPAGTPVGMTSIFMHDNPVVFPQPREFRPERWFEADFETVQAMNRHFVPFSKGSRMCLGMNLAYAEIYLVLAVLFRRYEISLSGVTREDIEMAHDFFDPAPKEGARGLIVQLQKRG
Nonribosomal peptide synthetase; part of the pathway that mediates the biosynthesis of the gray-brown conidiophore pigment . The first step of the pathway is performed by the nonribosomal peptide synthetase ivoA that catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion . While the stereoinversion is catalyzed by the epimerization (E) domain of ivoA, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a non-canonical C domain function . D-tryptophan is acetylated, probably by an endogenous acetyltransferase (Probable). N-acetyltryptophan is further 6-hydroxylated into N-acetyl-6-hydroxytryptophan (AHT) by the cytochrome P450 monooxygenase ivoC . N-acetyl-6-hydroxytryptophan is substrate of the N-acetyl-6-hydroxytryptophan oxidase ivoB to produce the gray-brown conidiophore pigment .
C8V7P3
B9IW60
DAPEL_BACCQ
N-acetyldiaminopimelate deacetylase
Bacillus cereus group
MVVSKFVQIRRDLHKIPEIGFKEWKTQRYILDYIGTLSNEHVEVKVWRTGVIVKVKGKNPEKVIGYRADIDGLPITEETGYEFASVHEGMMHACGHDLHTTIGLGLLTAAVTERIDDDLVFLFQPAEEGPGGALPMLESEELKEWKPNIILGLHIAPEYPVGTIATKEGLLFANTSELYVDLKGKGGHAAYPHTANDMIVAASHLVTQLQSVISRNVNPLDSAVITIGKITGGTVQNIIAEKSRLEGTIRTLSVESMSRVKSRIEGIVAGIEASFQCEAIIDYGAMYHQVYNHEALTREFMQFVSEQTDMKVITCTEAMTGEDFGYMLQEIPGFMFWLGVNSEYGLHHAKLKPDEEAIEKAIVFLDQYVKWKGTRK
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
B9IW60
Q73G09
PDXH_WOLPM
Pyridoxal 5'-phosphate synthase
unclassified Wolbachia
MAVALIFATRARIKILFFDMIFSLEKDPFDLFSKWYKAVLNSPCEQPTAMTLATCSKDCIPSARVVLLKEYSKEGFVFFTNVNSKKGKELTENPKAALVFHWIEFARQVRIEGEVKLLNDERTDKYFSSRALGSQISAWCSKQSSILKDWQDFEQAIKLKEKEFHNTQVSRPDFWVGFCVIPKVIEFWQEGEYRKHIRFRYTLVEGSDWKVEQLYP
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Q73G09
B2A3L2
RLMH_NATTJ
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Natranaerobius
MKFRVVAVGKIKEKYLIRGIEEYQKRLRPYTGLEITEVKDSVLPNKLYQAEIEKVLIEEENRIKSKLSSRDYIIALDSEGSQFTSENFAQQIENLTLEGINQFTFIIGGTLGLSNSLKKEANMLLSFSKFTFPHQLMRLILTEQLYRAIKIIHNEPYHY
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
B2A3L2
Q7U322
MURG_HELHP
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Helicobacter
MFAITGGGTGGHLAIAKALAQEAQKNNQQSIYIGSQIGQDKTWFEGSSLFTHCYFLDSTGVVNKKGLGKIKAIFKQLKAAWEARNILKKHKIEYVISVGGFSAGGASIGAILSNTPLFIHEQNAIKGKLNEILTPFAKAIFGSFEGKSKNFIHTSYPVRDEFFTHSRVREKLHHLLFLGGSQGAKGINDFALQIVPELLKRGITIAHQCGERDFERIKKAYEHIGILDKVDVFAFDKEIVLRLQKADLCIARSGASSLWEMSANGLIGIFVPYPYAAKDHQYYNALHFTKQGLGLLLRESQLDMLRVFTFIESLQKQEDSLSEKSHLLMSKIQPNGAKEILEHITSLMSH
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Q7U322
P36955
PEDF_HUMAN
Serpin F1
Homo
MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
P36955
B7VI55
HFQ_VIBA3
RNA-binding protein Hfq
Vibrio
MAKGQSLQDPFLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARAVSHHSGEQQRAPSDRPEKTED
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
B7VI55
Q5FPL0
GUAA_GLUOX
Glutamine amidotransferase
Gluconobacter
MTLTQQDASTVEKLDETLHEDRILILDFGSQVTQLIARRVRESGVYCEIWPFTATEEKIRAFNPRGIILSGSPASVHDENAPPIPNVVFALNRPVLGICYGQQAMCQMLGGKVESHEHREFGRAYIDIAEDCSLFRGVWARGKREQVWMSHGDRVTQLPPGFRAVAHSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALIRNFTHNVAGCSGTWTMAGFRELEIARIRKQVGSGRVICGLSGGVDSSVAAKLIHDAIGDQLTCIFVDPGIMRTGEADEVVKTFRGRFNIRLVHRDASELFLKELAGVTDPETKRKTIGRLFIEVFEEEAAKLGGAQFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPDRMNMELVEPLRELFKDEVRMLGRELGIPESIVGRHPFPGPGLAIRIPGDVTKEKLDLLRKVDAIYLEEIRRAGLYDAIWQAFAVLLPVRTVGVMGDGRTYDQACALRAVTSTDGMTAEVYPFDFAFLNRVAGRIVNEVRGINRVTYDITSKPPGTIEWE
Catalyzes the synthesis of GMP from XMP.
Q5FPL0
Q5B8A3
PKFD_EMENI
Aspernidine A biosynthesis cluster protein pkfD
Aspergillus subgen. Nidulantes
MGSLWSSPSLLPSQQDNETEPFSHLPKEIGTDPTLREDSNVSNRNSEAASTSTDSSTNTNENHASTSQSSLEGAPDSGPIKIAIIGGGIIGIITALGLIHRGINVTVYERAPKYTETSAGFSFSKGARKAMEIVSPRVLEALLRVAAPNKHPFIRYFDGFTPGADEAQWQIPAERPDYYGCLRAAFLESLGQEVPEGIVKFGKVLESYEDNEEGKVLLRFRDGSTAEVDAVIGCDGIKSRTRRIMLGDTHPAAAPGYTEIVAYRAVLPLEGVVAALGEDRGHSHCLAVGPDAYTVSYPIANKPLANMILFRKQRGSWANSDKLLETCHRSTAQDAVKDWKPEIQRLVDLLPENPNKWAIFDTSDNPVPSYVSASGRVCIAGDAAHASTPFLASGAAMGVEDAAVLATVLNTALKEQSYNKTTVVKRKAITAAFQAYSGIRMQRSQRVVKDSRTVGEVCMWQDAETARDPEKCFQAIWQRYTQIWEFDVEEMVERARSECVRLFS
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone . The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA . Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable). Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E . The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable). The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded (Probable).
Q5B8A3
A1JRE8
MDTJ_YERE8
Spermidine export protein MdtJ
Yersinia
MMIYWIFLGLAIVAEIIGTLSMKYASVSGELTGHIVMYFMITGSYIMLALAVKKVALGVAYALWEGIGILIITVFSVLWFDESLSPLKIAGLVTLVGGIMLVKSGTRKPKKPNSPNRNSGEHHATA
Catalyzes the excretion of spermidine.
A1JRE8
Q47ZE0
FOLD1_COLP3
Methenyltetrahydrofolate cyclohydrolase
Colwellia
MSALILDGKSVTKKSEEDLRSRVARLKELSNGAVPILATILVGNDPSSATYVKMKSNACTRVGMDSLKVEMSEETTTEELLAEIAKLNANPNIHGILLQHPVPPQINERQCFDSIDLSKDVDGVTCWGFGRMAMNETSYGSATPKGIIRILEAYDIQLEGKHAVVVGRSPILGKPMAMMLLNKNCTVTICHSKTVGLDKIIKTADIVVGAVGKPEFIKADWIKDDAVVIDAGYHEGGIGDIELQPLMSRVKAYTPVPGGVGPMTINTLIYQTVEACELKLAQ
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q47ZE0
A4XKI9
YBEY_CALS8
Endoribonuclease YbeY
Caldicellulosiruptor
MKIIIQNQQDKYQIDESISKIIEDSVLNTLKIFMDDENYEISVMIVDNQFIKELNKHYRSIDKETDVLSFPIFEFKNGELQEDIAIVEEEIPLGDIVISIEKAYEQAKEFGHSVEREIAYLTVHSVLHLLGFDHIEEEDRMLMRKYEEMVLEGMGLTR
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
A4XKI9
Q46A53
FOLD_METBF
Methenyltetrahydrofolate cyclohydrolase
Methanosarcina
MLDEGYESRIIDGKVLAKKIEDEVRSGVEALVSGRGITPGLATVLVGDDPASKMYVRLKHRACERVGIQAEDHFLPAETSQEELISLINTLNKDQNVHGILLQLPLPKHLFPQEAMEAIAPEKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNVVIVGHSNVVGKPLAAMFLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEKDGVYGDVDFENVIKKAALITPVPGGVGPLTVAMLMKHVLGCAETNY
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q46A53
Q0TPJ9
DER_CLOP1
GTP-binding protein EngA
Clostridium
MSKPIVAMVGRPNVGKSTLFNKLAGKRISIVQDTPGVTRDRVYAESEWLNRKFTMIDTGGIEPESSDIIVKQMRRQAQIAIEMADVIVFVVDGKEGLTAADQEVAQMLRKSKKPVVLVVNKIDRLALEENSYEFYNLGIGDPITISASQGLGLGDMLDEVVKYFNDPSEDEEDDEYIRIAMIGKPNVGKSSLINRLLGEERVIVSNVPGTTRDSIDSYLETEDGKFILVDTAGLRRKSKVKEEIERYSVIRTYAAIEKADVAILVIDAEQGITEQDEKIIGYAHEMNKAIMVVVNKWDLIEKDDKTLSNYQKDLQQKLKFMPYAKYLFISALTGQRVHKILSTAKYCYDNYSKRVSTGLLNDVISKAVLMKEPPVVALKRLKIYYATQVATKPPKFVFFVNDPNLLHFSYGRYLENQLRESFDFDGTGIEIEYRARKE
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Q0TPJ9
P16362
CYB_POMSU
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Pomatostomus
TALLLAAHYTADTSLAFASVTHMCRNVQFGWLIRNLHANGASFFFICIYLHIGRGLYYGSYLNKETWNIGVILLLTLMA
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
P16362
A7MXE5
RL11_VIBC1
50S ribosomal protein L11
Vibrio
MAKKVEAYIKLQVAAGMANPSPPVGPALGQHGVNIMEFCKAFNAKTESLEKGLPTPVVITVYNDRSFTFVTKTPPAAVLLKKAAGVKSGSGRPNTEKVGTVTDAQIQEIAETKAADMTGADIEAMKRSIAGTARSMGLVVEG
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
A7MXE5
B7N727
SYDP_ECOLU
Protein Syd
Escherichia
MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRAHLASNLAEFLNQLKPLL
Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
B7N727
Q4WJ90
ACON2_ASPFU
Aconitase 2
Aspergillus subgen. Fumigati
MVRQLVWQRATASRRLAPKCLSPQQLFARRGLATEASAARMPPYPKIVRNLEQVRKVLGSSRALTLAEKILYAHLDNAEESLLTGTNNGKDIRGKANLKLKPDRVAMQDASAQMALLQFMSCGLPSTAVPASIHCDHMIVGERGADTDLPASIEGNREVFDFLESAAKRYGIEFWPPGAGIIHQSVLENYAAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALVDAPWELKAPRILGVRLEGRLSGWASPKDIILHLAGKLTVRGGTGYVIEYHGPGVETLSCTGMATCCNMGAEVGATTSVFPFSPSMVPYLQATHRGHVAQAAAEIAASGPKNLLRADDGAEYDQLITIDLSTLEPHVNGPFTPDLSVRLSDFANTVRENKWPETLGAGLIGSCTNSSYEDMTRAEDLVKQASAAGLKPKADFFITPGSEQIRATLDRDQTLASFSEAGGTVLANACGPCIGQWKRTDGVAKGEDNAIFTSYNRNFPGRNDGNRRTMNFLASPEIVTALAYSGSTTFNPMTDTLKTPSGEEFKFRPPQGSDLPSAGFADGNPALQPSAGVPDASVEVIVSPTSERLALLEPFAPFPEGELSGLKVLYKVKGQCTTDTISAAGPWLKYKGHLPNISANTLIGAVNAATGETNVAYDDAGNKHSIPDLAARWKADGIEWLVVAEDNYGEGSAREHAALQPRYLGGRIIVAKSFARIHETNLKKQGVVPLTFADKADYDRIDACDQVDTVGLYETLQSGGQGSIQLQVTKKSGEKLTIPVNHTLSKDQCGFILAGSALNLLAKRAHQ
Has no detectable activity towards cis-acontiate or cis-homoaconitate.
Q4WJ90
Q7WZY5
NREB_STACT
Nitrogen regulation protein B
Staphylococcus
MKSISNRDKLQDLLTQYYLNTNEKMVFLNSTGEVIALNEAAEEVFADDNDYSQMTNAVCRRCEGYSNEYDIMSCENCFLEALEIGKGSFQVFIRTKDNKIQPYTASYELIDHEKGIYAFTLHNVSPQIQRQERMYQRKMMQKTISAQENERKRISRELHDGIVQELINVDVELRLLKYQQDKDELIDNSKRIEGIMSRLIDDVRNLSVELRPSSLDDLGLDAAFRSYFKQFEKNYGIHVNYHTNFSAQRFDNEIETVVYRVVQEALFNALKYAQVDIVEVSLQLNENNIIAEVSDRGVGFKRGDDPKGTGLGLFGMNERAELVNGTVNIDSQINRGTIVTLEVPITD
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Q7WZY5
B9KIN8
TRUA_ANAMF
tRNA-uridine isomerase I
Anaplasma
MRYRAVVEYDGTAFIGWQRQKGVAGRSVQESIEDAIYRLSQQHVTVFAAGRTDAGVHALGQVVHFDLNTSLQDYVIKNALNHYLRSDMVSILSLEEAAEGFHARFSAKKRHYMYKIVNRDAPPCLDRLRMWHVPKQLNVSDMQEAASHMVGEKKDFASFRAKECQSKSSVRTVDRIDCVREGNNIFVHVSAKSFLHKQVRIIVGTLVQCGHGAFPPSYVLEILERKNRAAAGITAPPHGLYLVLVEY
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
B9KIN8