accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q02326
RL6A_YEAST
YL16
Saccharomyces
MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANLFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDKPHMLKF
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Q02326
Q2J542
ISPD_FRACC
MEP cytidylyltransferase
Frankia
MGEGHRLPVASPRVAAIVPAAGRGERLGGGTPKALRALGGRPMLVRTVESLRRSRLVTQIVVAAPPTLVDAVAQLLGGDVYVIAGGAERVDSVRRALRAVDDDVSVVLVHDAARPLTPPELVDAVAAAVLDGHPAVIPVVPLADTVKEVDADGRVVRTPPRDGLRAVQTPQGFRRDVLSAAYALEDIAVTDDAGLVEALGVPVTTIPGAQEAFKVTRPADLVLAEALLARCDPADDARSAEARSAEARSEEPQFAGARSTDARSGG
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Q2J542
P15325
QUTD_EMENI
Quinate transporter
Aspergillus subgen. Nidulantes
MSILALVEDRPTPREVYNWRVYLLAAVASFTSCMIGYDSAFIGTTLSLQSFQNEFNWESLNTDLISANIVSLYQAGAFFGALFAYPIGHFWGRRWGLMFSALIFFLGAGMMLGANGDRGLGLIYGGRVLAGIGVGAGSNICPIYISEMAPPAIRGRLVGVYELGWQIGGVVGFWINYGVDETLAPSHKQWIIPFAVQLIPAGLLIIGALLIRESPRWLFLRGNREKGIETLAWIRNLPADHIYMVEEINMIEQSLEQQRVKIGLGFWKPFKAAWTNKRILYRLFLGSMLFLWQNGSGINAINYYSPRVFKSIGVSGGNTSLLTTGIFGVVKAVITFVWLLYLIDHFGRRNLLLVGAAGGSVCLWIVGGYIKIAKPENNPEGTQLDSGGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDPTVRSLAQACAAASNWLWNFLISRFTPQMFTSMGYGVYFFFASLMILSIVFVFFLIPETKGVPLESMETLFDKKPVWHAHSQLIRELRENEEAFRADMGASGKGGVTKEYVEEA
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
P15325
P60235
3SI13_DENAN
Muscarinic m1-toxin3
Dendroaspis
LTCVKSDSIWFPTSEDCPDGQNLCFKKWQYISPRMYDFTR
Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.
P60235
B2TPW4
ENO_CLOBB
2-phosphoglycerate dehydratase
Clostridium
MNDYLEIIDVVARQILDSRCFPTVEVEVYLEDGTIGRAAVPSGASTGMYEAVELRDGDKDKYLGKGVLTAVQNVNDTIAEALIGCNVFDQPYIDKMLIELDGTDNKGKLGANAILGVSLAVANAAANALGLSLYKYVGGVNAKVLPVPMMNIINGGSHADNSVDLQEFMIMPVGATSFTEALRMCAEVYHTLKNTLKDKGYATGLGDEGGFAPNLKSNAEAIDVIIEAITKAGYKAGEDMFIAIDAASSEYYKDGKYVLENEGKTLTSAEMVDFFEDWVNKYPIISIEDGMAEEDWDGWKLLNERLGKKVQLVGDDLFVTNTERLEKGIEIGAANSILIKLNQIGTLTETLNAIEMANRAGYTAVISHRSGETEDTTISDLVVAVNAGQIKTGAPARSERVAKYNQLLRIEEELEDVAEYRGKKAFFNIKK
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
B2TPW4
B7N237
SELA_ECO81
Selenocysteinyl-tRNA(Sec) synthase
Escherichia
MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRDSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVMKAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
B7N237
A7MIM0
ISPH_CROS8
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Cronobacter
MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARSSRRGEEAILIGHAGHPEVEGTMGQYSNPEGGMYLVESPEDVWKITVKDENNLSFMTQTTLSVDDTSEVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGKTAYLIDDANDIQEAWVQNAACVGVTAGASAPDVLVQNVITRLKALGGSDAHELTGREENIVFEVPKELRIDAREVQ
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
A7MIM0
P38162
MIX23_YEAST
Mitochondrial intermembrane space CX(n)C motif protein of 23 kDa
Saccharomyces
MVDNRRTFTAPQSLLETNLTFPNDEPSLTTITVTRERCVDPSLIDSFLRFLRHGSDDIIRQKLNNYRKGSINGKNKCKEFLKQELYPNWQIRNNIISFCEKEAAEMKNETDQQCGNNKKTTAEPLIDARIDPYAARERAEKQEAQYKDWTKVTEWVANNRKIEQILTSTTEGILRQNCEQNNDYLKEFTQFCKDNS
Regulator of the mitochondrial protein import machinery that is localized in the mitochondrial intermembrane space (IMS) and facilitates the transport of proteins from the cytosol into the mitochondrial matrix . Not essential for mitochondrial protein import but induced and required when mitochondrial import is compromised . Stimulates or stabilizes the translocation into the mitochondria of proteins such as OXA1, ATP1 and COX12 .
P38162
Q211G4
RL18_RHOPB
50S ribosomal protein L18
Rhodopseudomonas
MSKLKITNARRKQRVRLSLRRIANGRPRLSVFRSSKHIYAQVIDDLKGETLASASSLEKAMRDTGNTGANIDAAKAVGKLLAERAVKNGVTEVVFDRGGYLYHGRIKALADAARESGLSF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q211G4
O54459
AROH_ENTAG
Phospho-2-keto-3-deoxyheptonate aldolase
Pantoea agglomerans group
MNKTDELRTARIGSLITPPSLAAEHPVSPAIADNVTAARKRIACILTGEDHRLLVVIGPCSLHDPKAALEYAERLNALRRRYEDRLEIVMRAYFEKPRTVVGWKGLISDPDLDGSYDVNRGIGIARQLLIDINALGLPTATEFLDMVIGQFIADLISWGAIGARTTESQIHREMASALSCPVGFKNGTDGNVQIAVDAIRAARASHMFLSPDKLGQMTIYQTSGNPHGHVILRGGKQPNYHASDVAAAAESLSAFNLPQQLVIDFSHGNCLKQHRRQMDVAAEVAEQIKAGSQAVAGVMIESFLEEGNQKVVSGEPLVYGKSITDPCLGWQESEKVLALLAEAVSHRL
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
O54459
Q14HG2
CYSN_FRAT1
Sulfate adenylate transferase
Francisella
MSHKSDLIATNIQKYLQQHQQKELLRFITCGSVDDGKSTLIGRLLHDSKLIFEDQLASIVADSKKVGTQGDRLDLALLVDGLQSEREQGITIDVAYRYFSTDKRKFIIADTPGHEQYTRNMATGASNCDLAIILIDARKGLQTQTRRHNFICSLLGIKHVIVAVNKMDTVGYSQQIYKSIQDEYLKLAGSLQIPDIRFVPISALDGDNVVSKSPKMPWFRGSPLMHYLETIKIDYAYTDEFRFPVQLVCRPNSEFRGFQGTVVSGSAKIGDTIRVMPSGKITTIKSILSFDGKLNEAEAGQSITITTYDEIDISRGDMIVHKDAISHVSSMLRANIVWMSEQPLIEYKDYYIKFLTKQVIGSVNKFNYKTDINTLKEVACGTLELNEIATIELKLSEPVCFDSYQKNRTIGAFIIIDRLTNVTAGAGMVIKPLAANDKKDSTNDYSEFELELNALIRKHFPHWDAKNLRE
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Q14HG2
B0WAM5
EIF3E_CULQU
Eukaryotic translation initiation factor 3 subunit 6
Culex
MSKFDLTAKNCQYLDRHLTFPLLEFLLQKNIYDQTSLLKFILETVSKTNMVDYTMDIRERLNMGNELPEELTKRRSNVLVKLKELQTEVAPLMKCMEELKNPDTMKDSKSIVHALQQEFDFKYDIIRSAQKLAKYLYECGNYRDSISYLYICLLVMEPTDKNYLNVLWGKLAAEILTLNWPTALEDLTRLRDFIDNHNFSPIEVLQQRTWLIHWSVLVFFNHAKGRDLIIEMFLYKQLYLNAIQTMCPHILRYLATAVIINRGRRNALKDLIKIIQQESYTYKDPITEFLECLYVNFDFEGARMKLHECQTVIINDFFIIGCLQEFIENARLMIFETFCRIHQCITIGMLADKLNMEPDEAECWIVNLIRNARLDAKIDSKLGHVVMGTQPLSPYQQLVEKIDSLSVRSEALTVLVERKQKAKTQESGEGNWKYY
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
B0WAM5
P52961
NAR1_HUMAN
Mono(ADP-ribosyl)transferase 1
Homo
MQMPAMMSLLLVSVGLMEALQAQSHPITRRDLFSQEIQLDMALASFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTRPSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTFFGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYNCEYIKDKKCKSGPCHLDNSAMGQSPLSAVWSLLLLLWFLVVRAFPDGPGLL
Has ADP-ribosyltransferase activity toward GLP1R.
P52961
Q98QN3
RS15_MYCPU
30S ribosomal protein S15
Mycoplasmopsis
MTDKKLVKELAIEFGGSEKNVGAIEVQIAILTHDIERLKIHFETNKKDKHSKRGFIAKINKRKKLLAYLKDVNFESYQTTIQKLKIRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
Q98QN3
O27765
PHOU2_METTH
Phosphate-specific transport system accessory protein PhoU homolog 2
Methanothermobacter
MWKLIGALLESRLSNVLDETVRYGNETSERVGRTVSSYIKGDEETARELIETTAAVNEKSYRIEDECLKILGLHQPVAKDLRLASSIMRSAIELERINILLAYIARYAIDGRDRTPPHIEFMSQTVQDMINDALGALMNRDIQLLKRSTRNYIQLQDLYNQLQESNRDFSESGNLMLVARNLLSMGHHVMGMDDRIAYLIVGKRVIHHKVFYSVLMK
Plays a role in the regulation of phosphate uptake.
O27765
Q1MJ01
RSMA_RHIL3
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Rhizobium
MAALDGLPPLRDVIQRHGLDARKALGQNFLLDLNLTQKIARTAGALEDATVFEVGPGPGGLTRAILALGARKVIAIERDTRCLPALAEIADHYPGRLEVIEGDALKTDFETLAPQGPIKIIANLPYNVGTQLLVNWLLPKAWPPFWQSLTLMFQKEVGERIVANEDDDHYGRLGVLCGWRTEARMAFDVPPQAFTPPPKVTSTVVQLTPRENPIPCAVSNLEKVTQAAFGQRRKMLRQSLKPLGGERLLVKAGIDPARRAETLSVKEFCLLANSL
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q1MJ01
Q1LIM4
MURD_CUPMC
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Cupriavidus
MFGVLQKPHVLVLGLGESGLAMARWCGLNGCRVRVADTREAPANLVFLQAELTTAQFMGGQFTENLLDDIGLVAISPGLSPLEPNTRALLEAAQARSIPVWGEIELFAQAIGYLEATSGYAPRVLAITGTNGKTTTTALTGRLIERAGKTVGVAGNISPSALDKLSACIASATLPDVWVLELSSFQLEYTFSLAPHAATVLNVTQDHLDWHGSMEAYAAAKARIFGPAEKGCLQVLNRQDPLTMNMARRGTTLVTFGTDLPETPGSYGVLREGGMPWLVLAEPDTEADAEQKPRRRKKDDVAADAVVPVRHKRLMPADALHIRGMHNATNAMAALALCRAIDLPLNALLHGLREYRGEPHRVEWVATIDEVEYFDDSKGTNVGATVAALSGLDKHVVLIAGGEGKGQDFSPLVAPVAQYARAVVLIGKDAGALREALGATGKPLIDAGSLEEAVEKSASLAEAGDVVLLSPACASLDMFRNYVHRAQVFRGAVEELALSRGIMP
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q1LIM4
Q5BK67
TIFAB_RAT
TIFA-like protein
Rattus
MERPLTVLQVSLYHPTQGPVAFAKVPLQLQHDASRLLVGRGQDTHLQLQLPQLSRHHLCLEPYLEKGSNLLAFCLKVLTRQSCVWVNGLPLRYLEQVPLHSVNRISFSGIQMLIRKEGGASLEAFVCYFHLSPSPLIYRPKAQETDE
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
Q5BK67
P60196
RNZ_STAAM
tRNase Z
Staphylococcus
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKDFDSFKV
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
P60196
O87778
DNAJ_LATSK
Chaperone protein DnaJ
Latilactobacillus
MAEKRDYYDVLGVGRDASDDEIKKAYRKLSKKYHPDINKAPDAEAKFKEVTEAYEALSDPQKRAAYDQYGHAGMNGGFGGGAGAGQGFGGFGGGAEGFGGFDDIFSSFFGGGARQQPNGPRQGSDLQYRMDLKFEEAVFGKETKISYSREAECHTCHGSGAKPGTSAETCHKCHGAGQIQVERQTPLGRMMSRETCDVCGGTGKEIKSKCDTCHGTGREEERHTVKVKVPAGVEDGQQMRLQGQGEAGSNGGPYGDLFIVFRVAPSDEFERDGAQIFVEVPISFVQAALGDEIEVNTVHGPVKLKIPAGTQTNTVFRLRGKGAPKLHGTGNGDQKVTVNVVTPKSLNSKQRDALKAFAVASGDSVNPQDNNLFDKILNKKHKK
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
O87778
A0JZ92
RPOC_ARTS2
Transcriptase subunit beta'
Arthrobacter
MSSESSFGLMQIGLATAEDIRGWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPSRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITSVDTDSRHEELPNLQVEHDIEKKQLVDNRDSDIATIARDLENELARLEGEGAKAADKKKARDSADRQMANVRKRADADIERLEQVWDRFKNLKVADLEGDEGLYRELRDRYGMYFEGSMGAEAIKKRLENFDMQAESDLLRDIIANGKGQRKTRALKRLKVVNAFLTTNNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDSLFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKQMALELFKPFVMKRLVDLNHAQNIKSAKRMVERYRPQVWDVLEEIITEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCGAFNADFDGDQMAVHLPLSPEAQAEARILMLSSNNILKPSDGRPVTLPSQDMIIGLYHLTTKRVGSAGEGRIFSSVSEAIMAFDLHELHLNSQVKIRLEGFVPYAGWEAPEGWEPGQTALVQTSLGQVIFNQTLPEDYPWVEAVADKGELSRIVNDLAERYPKVVTAATLDNLKDAGFYWATRSGVTVAISDIEVPAEKPVILAGYEERAAKIQGQYDKGLIDDDERRQELIEIWNKATNEIAQVMRDNLSPMNTINRMVSSGARGNWMQVRQIAGIRGLVANPKGEIIPRPIKSSYREGLSVLEYFIATHGARKGLADTALRTANSGYLTRRLVDVSQDVIVREEDCGTERGLVTPIAVADANGELVLDENVENSAYARTLAVDVVDSKGKVLAAGGTDCGDVVIAELFAAGITEVKVRSVLTCESSVGTCALCYGRSLATGKTVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGAVSASGGDDITQGLPRIQELFEARTPKGVAPIAEAAGRIAIEESERQMRLVITPDDGSEEIAYPVLRRSRLLIEDGQHVAVGQKLINGPVDPKQVLRIMGPRAAQKFLVDEVQGVYRSQGIGIHDKHVEVIVRQMLRRVTVIESGESDLLPGELAERSRFEDANRRVVSEGKTPASGRPELMGITKASLATESWLSAASFQETTRVLTQAAMEGKSDPLLGLKENVIIGKLIPAGTGLPRYTEVTVEPTEEAKANLFTGPSAFSDFSYDTLGGDGAPEFHAIPLDDYDLGSDFR
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A0JZ92
P10785
HBB1_TRICR
Hemoglobin beta-major chain
Triturus
TFTNDESQHIHDVCGKIPVDQVGAEALGRLILVNPWTRRYFKSFGDLSSAEAIQHNPKVASHGAKVMHSIAEAVKHLDDLKAYYADLSTIHCKKLYVDPANFKLFGGIVSIVTGMHLGTDYTAQKQAAFEKFLHHVEAALATGYH
Involved in oxygen transport from the lung to the various peripheral tissues.
P10785
Q59NX9
DPH51_CANAL
Diphthamide biosynthesis methyltransferase 1
Candida
MLYLIGLGLSYESDITVRGLETVKKCKRVYLEAYTSILMAANQESLEKFYGREIILADRELVETGSDDILKDADKEDVAFLVVGDPFGATTHTDLVIRARELGIKVETIHNASVMNAVGACGLQLYQFGQTVSLVFFTDSWKPDSFYGKIMENRKIGLHTLLLLDIKVKEQSIENMARGRLIYEPPRYMDIATAAQQLLEIESIRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLHSLVMLGRQVHELELEYLYQFVDDKEKFKKFVEQDQEFFKPAPYVPPEDVDSE
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Q59NX9
P35469
CH601_RHIME
Chaperonin-60 1
Sinorhizobium
MAAKEVKFGRSAREKMLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLLAKAKKINTSDEVAQVGTISANGEKQIGLDIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAFILLHEKKLSNLQAMLPVLEAVVQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRAKKVSITKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRIDDALNATRAAVQEGIVPGGGVALLRSSVKITVKGENDDQDAGVNIVRRALQSPARQIVENAGDEASIVVGKILEKNTDDFGYNAQTGEYGDMIAMGIIDPVKVVRTALQDAASVASLLITTEAMIAELPKKDAPAMPGGMGGMGGMDMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P35469
B3LP25
MDG1_YEAS1
Multicopy suppressor of defective G-protein 1
Saccharomyces
MQSSLPQFTFKWPKGPEAIILTGTFDDWKGTLPMVKDPSGAFEITLPVTFDSPSSKFYFKFIVDGQWLPSKDYKVNIDEGVENNFITEEDVLKQRENGSSTLVPESAGLAVSKNAPLIEPEAEKRAKKLRKFKIKRVIKTNKQTGERSIFSQEVVELPDSEDETQQVNKTGKNADGLSGTTTIIENNVGVNEEKAIKPYEENHPKVNLVKSEGYVTDGLGKTQSSESRLYELSAEDLEKEEEEEDEDKGGGKDTSTSADAEASEDQNKEPLSKSAKFEKPEEKVPVSSITSHAKETSVKPTGKVATETQTYETKQGAPTAAAKKIEAKKATRPSKPKGTKETPNKGVQKNPAKNGGFFKKLAQLLK
Involved in G-protein mediated signal transduction and in the regulation of polarized cell growth in pheromone-induced cells.
B3LP25
B0RQ26
PQQD_XANCB
Pyrroloquinoline quinone biosynthesis protein D
Xanthomonas
MSTISRDSCPALRAGVRLQHDRARDQWVLLAPERVVELDDIALVVAQRYDGTQSLAEIAQTLATEFDADASEIETDVIELTTTLHQKRLLRL
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
B0RQ26
A4Y931
SYA_SHEPC
Alanyl-tRNA synthetase
Shewanella
MYQTTAELRSAFLEFFRSHGHQVVDSSSLVPGNDPTLLFTNAGMNQFKDVFLGMDKRNYTRATTAQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEEAICFGWSFLTETLKLPKERLCVTIYQTDDEAFEIWNKKIGVAAENIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGRPGSPEEDGDRFIEIWNIVFMQYNRHISGEMLPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFRALIAKAAEIIGVTDLSNKSLRVIADHIRSCAFLVADGVMPSNEGRGYVLRRIIRRAVRHGNKLGATEAFFYKLVPTLIDVMGDAAKGLAETQVIVEKALKAEEEQFARTLERGLGILDAALSELTGDTLDGETVFKLYDTYGFPMDLTADVCRERNIIVDEAGFEAAMAEQRSRAQAAGNFGADYNAALKIDAETAFCGYTELVGQAKVTAIYQNGESVTAIKAGDEAVLVLDVTPFYAESGGQVGDKGQLVANGIEFTVNDTQKYGQATGHQGVLVAGSLSIGQMVEAKVDKKLRHRTQLNHSVTHLLHAALRQVLGTHVTQKGSLVDPERLRFDFSHFEAVKPAELKKVEELVNTQIRRNHELKVAEMAIDEAKEKGAMALFGEKYDAQVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEGGIAAGVRRIEAVTGAAAMAYVAQQQAELEEAAALLKGDTHSVVAKLKAQLDKMKQLEKDMAQLKDKLAAAASADLVGDAVVVNGVNVLIKKLDGVEAGSLRGLQDELKQKLKSAIIVLGTAQEGKVNLIAGVSNDLVGKVKAGELVAMVAAQVGGKGGGRPDMAQAGGSQPENLDAALAQVLPWITERLA
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
A4Y931
Q7WJQ9
PCKG_BORBR
Phosphoenolpyruvate carboxykinase [GTP]
Bordetella
MNKPSEVKPVALNVPDYVKHSGLIAWVERIAALTKPDRVVWCDGSQEEYDRLCEQMVQGGTMRRLNPAKRANSYLACSDPSDVARVEDRTFICSEREEDAGPTNNWAAPQAMRETLGGLFDGAMRGRTMYVVPFSMGPLGSPIAHIGVELSDSPYVVVNMRIMTRMGRKVFDVLGSDGAFVPCVHSVGMPLAEGQQDVAWPCNPTKYIVHYPETREIWSFGSGYGGNALLGKKCFALRIASTMGRDEGWLAEHMLILGVTSPKGRKYHVAAAFPSACGKTNFAMLIPPHGMDGWKVTTIGDDIAWIKPGPDGRLHAINPEAGYFGVAPGTSEKTNFNAMATLKANVIFTNVALTDDGDVWWEGMTDTPPAHLIDWQGQDWTPAIAAETGRKAAHPNARFTAPAAQCPSIDPEWENPKGVAIDAFIFGGRRSTTVPLVTEARNWVEGVYMAATMGSETTAAAAGQQGVVRRDPFAMLPFCGYNMSDYFDHWLKLGRRLEETGATLPRIYCVNWFRKGPDGKFVWPGFGENMRVLRWMLGRLDGQAGGVDQVFGISPAYGDIDWTGLEFSPDKFEQVISVDLPAWRAELALHDELFTQLAARLPEDLPLTRTAIERRMAA
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Q7WJQ9
Q71PB7
NU6M_BOSIN
NADH dehydrogenase subunit 6
Bos
MMLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPEIWLSNKAVLGAFVTGLLMEFFMVYYVLKDKEVEVVFEFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSLLIGVVVIMEITRGN
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q71PB7
Q3AEY1
PDRP_CARHZ
Putative pyruvate, phosphate dikinase regulatory protein
Carboxydothermus
MAINLKLEQIPVVYILSDSIGETGEVVAKAAASQFDSGRVDIRRVPYLSSVREVEEALQEAESAGALVVYTLVRPDLKEYLEKRAHELSLPHVDIMGPMLEGLKQITKQNPKYQPGLIRKMDEAYFSKVEAIEFAVKYDDGKEPRGLLRADLVVIGVSRTSKTPLCMYLAHKGIKAANVPLVPEATPPEELFKIPPHKVVGLTIKPSILFEIRKERLKTLGLSQTADYANMERILMELDYALGIMKKIGCAVIDVSNKAVEETAARVLEIYRKGVGR
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
Q3AEY1
C0Q8N5
RSMH_DESAH
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Desulforapulum
MKFEHRSVMPREVRDGLDLKPGETCVDCTLGGSGHAVTSLAAVLPNGRLIGIDQDLDAIENAHRVFADDMANVSIFHDNFSHLPAILDSLGIKGVDGILLDLGLSLHQLRKGQRGFSFKGDEPLDMRMDMRTALTAADLVNTLEERALVDIFFKYGEEKMSRKIARAIVRQRASAPITRNCELAEIVRAAIPAKIVHQQKIHPATRVFQALRISVNRELEQLERFLETFVDFLNPGGRICIISFHSLEDRMVKRRFRALEQGCTCPRDFPECVCGFKPRLKSVTKRAVMPTPEEIEINPMARSARLRVAWRV
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
C0Q8N5
Q9WTV0
PREB_RAT
Mammalian guanine nucleotide exchange factor mSec12
Rattus
MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNGVHFLQLEQISGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQIHQQKGSKAEKSGSKEQGPRQRKGAAPAEKKSGAEVHPEGVELKVKNLEAVQTDFSTEPLQKVVCFNHDNTLLATGGSDGHVRVWKVPSLEKVLEFKAHEGEIGDLALGPDGKLVTVGWDFKASVWQKDQLVTQLQWQENGPTSSNTPYRYQACRFGQVPDQPGGLRLFTVQIPHKRLRQPPPCYLTAWDSSTFLPLQTRSCGHEVISCLTVSESGTFLGLGTVTGSVAIYIAFSLQRLYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
Q9WTV0
Q4A881
RL19_MESH7
50S ribosomal protein L19
Mesomycoplasma
MQAKLIEILESSQIRLYPQFQPGDNVRVYFKIQEGNKTRIQIFEGLVIKFKKNGLSSNFVVRKISHNVGVERTFLLHSPLVDKVEVIRSNKVRRAKLYYMKKRSGKSARLKEIKRKELKNL
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Q4A881
A6Q3V4
RNY_NITSB
Ribonuclease Y
unclassified Nitratiruptor
MWVEILVGSSAAIISGAAGYLLSKKIEKDKLKIYEEQARAKAKAIEHEAEKILQNAQVQVKEAELELKRDFEKKLEELKRDYEERFNELMEKEMSLKQMFKDELKHITLEKQEIKAEREEINRLKNEYEELKKRYQEKYQEVLEALQQQAGLTLEEAKNLILQKAEEESRLEIANIVRKYEEEAKREAKRRANYIIAQATTRFAGEFAAERLINTVSIPSEDIKGRIIGKEGRNIKTLEMLLGVDIIIDDTPNAIILSSFNLYRRAIATKVIELLVEDGRIQPSRIEEIYEKVKEEFDQQLLEEGENIVIDLGIGLIHPEIVKLIGRLKFRASYGQNALGHSLEVAHLAGIMAAEMGGDEVMAKRAGLLHDIGKALTHEYSGSHVDLGAEICKRYKEPDVVINAIYAHHGHEEPRSIEAAAVCAADTLSAARPGARREVLEAFLKRVQAIEEIALSKPGVKKAYAINAGREVRVIVNADLVNDNEAVLLAKEIAKDIETGVQYPGEIKVNVIRENRAIEYAR
Endoribonuclease that initiates mRNA decay.
A6Q3V4
Q5HKN7
HIS1_STAEQ
ATP phosphoribosyltransferase
Staphylococcus
MLRVALAKGRLLKSFIEYLQQVNQIDIATVLLNRQRQLLLTVDNIEMILVKGSDVPTYVEQGIADVGIVGSDILNGQKYNINKLLDLPFGKCHFALAAKPETSRYKKVATSYVHTATQFFNKEGMDVEVIHLNGSVELSCVVDMVDAIVDIVQTGSTLTANGLVEKKHISEINAKLITNKESYFKQSSEIERLIKQLGVSINYA
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Q5HKN7
A4XK06
HEM3_CALS8
Pre-uroporphyrinogen synthase
Caldicellulosiruptor
MKKLRIGARDSKLSRIQVDIVARKIKQTLGIECEFVPIKTKGDIDKTKSLKDFKSPGVFVKEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNAKIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHVSYIFDVNEITPCPGQGAICIECLKDSPYKNILSKINDADAYIQTQFERLVLKFLGGGCHSSIGVFCKTDQDKIYAFASILSGDKLIKASIEGDKDDFLSLANKLSNMLKS
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A4XK06
Q3EC60
SUVHA_ARATH
Suppressor of variegation 3-9 homolog protein 10
Arabidopsis
MGLVGLHSGTIDMEFIGVEDHGDEEGKQIAVSVISSGKNADKTEDPDSLIFTGFGGTDMYHGQPCNQKLERLNIPLEAAFRKKSIVRVVRCMKDEKRTNGNIYIYDGTYMITNRWEEEGQNGFIVFKFKLVREPDQKPAFGIWKSIQNWRNGLSIRPGLILEDLSNGAENLKVCLVNEVDKENGPALFRYVTSLIHEVINNIPSMVDRCACGRRSCGSKHVFREKLSVSSSLVISAKKSGNVARFMNHSCSPNVFWQSIAREQNGLWCLYIGFFAMKHIPPLTELRYDYGKSRGGGKKMCLCRTKKCCGSFG
Histone methyltransferase family member that may lack methyltransferase activity. May methylate 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression (Potential).
Q3EC60
D8IJV0
RNM51_LIGS5
Ribosomal RNA terminal maturase M5 1
Ligilactobacillus
MNENDKMKIKEVIVVEGKDDTKRIQMAVNADTLETRGSAISDETLDQIEDLYDKRGVIVFTDPDFSGEKIRKIITEAVPGVKHAFLTKHDAAPSHKGSLGVEHASPEAIREALAHLYTEVPDGEPLISREDLAVAGLTSGPQAKEYRRRLGEYLRIGYTNGKQLYKRLKLFQITPDELKKALEYIKNEDNY
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
D8IJV0
O67104
BIOB_AQUAE
Biotin synthase
Aquifex
MDKVERRLYELYEKAINYEPLSKEEALYILEVDDIYVPFLVHLAQKIKKHYFPENEVEFCSIINAKSGACSEDCKFCAQSKYYKTPINVYNLVPVDEMVEGAIRGVEFGANRYCIVLSGKSATKEEVERITEAVKEIKNEGLPINVCVSAGTLDEESLKKLKEAGVKRINHNLETSRNFFKNIVTTHTWEDRYETIKRIKKVGLSTCSGGIFGMGESNEDRVDMALTYRELEVDSIPLNFLMPIEGTPMENAPGVEVMEALKIIAMFRFTNPKAELRLCGGREQNLRDFHGMATLMTNAMMVGGYLTRAGRDIKKDYQLLKDLKAKRKVSVE
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
O67104
B6YSL7
RS19_THEON
30S ribosomal protein S19
Thermococcus
MARKKEFRYRGYTFEELLNMSLEDFAKLLPARQRRSLKRGLSPEQKKLLRKIRLAKKGKYNKPIRTHSRDMVILPEMVGMTIHVYNGKEFVPVEIKEEMIGHYLGEFALTRKIVQHGSPGVGATRSSMFVAIK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
B6YSL7
Q12891
HYAL2_HUMAN
Lung carcinoma protein 2
Homo
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Q12891
D9PZU4
PUS10_ACIS3
tRNA pseudouridine 54/55 synthase
Acidilobus
MNEDPAQQAMKVLAKYPLCDRCLGRLFAGLGRGLSNAERGRALKLSVVMSLHAMSLSGRLPENARDVLANAGGAAAQVYVELFGSPPEHRSCYICNDALDKFLDEMPQRVADAVKEWGGSTFLVGAKVDPGVIAREERIKAEFGLAFGESIKSEIKRELGKRAQQLGPKVSFDRPDVVVMVSFPDGSVSVQPRRLVVKGLYRRLRRDLQLRPREALSHPLVARLINDTRSSRVGIVGLVRDEKEVRALGLGIPVEFHLGGPRVRLVPPDGSIIEAEGASLEVNSSVEASGPEDLSRRVRVYRCVLYVEGGAFESLQLAAASLRGKEVRQKFMGKEVSGVVRGAECVDMGGGLAECIIALDERLHVMELVSGSGTEPSLSGLLGTAAECVVADLLGVIPLR
Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
D9PZU4
Q87MQ1
APT_VIBPA
Adenine phosphoribosyltransferase
Vibrio
MTTETISLIKSSIKSIQDYPKPGILFRDVTSLLEDAKAYQATIGLLVERYKDMGFTKVVGTEARGFLFGAPLALELGVGFVPVRKPGKLPRPTIAQSYELEYGIDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIGGDKRLEALGLNVFSICDFEGH
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Q87MQ1
Q3ICG2
MINE_PSET1
Cell division topological specificity factor
Pseudoalteromonas
MSLLDYFRSEKKNSASLAKERLQIIVAHERSQRGTPDYLPQLKQDILDVIRKYVNVSSDAVQVQFDQNEDDLAVLELNVTLPDEEPKI
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
Q3ICG2
Q0ABG5
RL14_ALKEH
50S ribosomal protein L14
Alkalilimnicola
MIQMQTTLGVADNSGARQVQCIKVLGGSRRRYAGIGDIIKVSVKDAIPRGRVKKGEVYNAVVVRTRRGVRRPDGSVIRFDGNAAVLLNNQLQPIGTRVFGPVTRELRSEKFMRIISLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Q0ABG5
B5YFZ0
GLYA_THEYD
Serine hydroxymethyltransferase
Thermodesulfovibrio
MKMKSLREVDAEIYSLILQEKKRETNKILMIASENYASRAVMEAQGSLFTNKYAEGYPGRRYYGGCEYADEVERLAQERAKQLFNVEHVNVQPHSGTQANMAVYFAMLQPGDTIMGMSLTHGGHLSHGSPVNFTGKLYKTVFYGVNKETGYIDMDEVRRLAQEHKPKIIITGASAYPRTIDFKAFSEIAKEVGAYLMADIAHIAGLIATSMHPSPVPYSDFITTTTHKTLRGPRGGVVMCKAQYAKAIDKTVFPGIQGGPLVHVIAAKAVAFKEALSEDFKEYQKKVIKNAKTLAEALKKKGFKLVSDGTDNHLMLVDLTNFNITGKEAEEALDKAGITVNKNTIPFDTKPPTVTSGIRIGTPSVTTRGMGEEEMEKIAEIIERVIKNISNDSVIKDMQKKVQELCKKFPIY
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
B5YFZ0
Q50940
CAH_NEIGO
Carbonate dehydratase
Neisseria
MPRFPRTLPRLTAVLLLACTAFSAAAHGNHTHWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE
Reversible hydration of carbon dioxide.
Q50940
A4JBS2
DNAJ_BURVG
Chaperone protein DnaJ
Burkholderia cepacia complex
MAKRDYYEVLGVAKNASDDEIKKAYRKLAMKYHPDRNPDNKDAEEHFKEAKEAYEMLSDGQKRAAYDQYGHAGVDPNMAGAGGQGFGGFADAFGDIFGDIFGQAAGGAARGGRGGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWVSCEVCHGSGAKPGTKPETCPTCHGQGTVRMSQGFFSIQQTCPKCHGTGTYIPEPCAHCHGSGKVKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPPGDLYVEIHIKPHAVFERDGDDLHCQMPIPFTTAALGGEIEVPTLAGRASFPVPEGTQSGKTFRLRGKGIKGLRSSIAGDLYVHVQVETPVKLTDQQRDLLKQFEKSLAEGGARHSPQSKSWFDRMKSFFE
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
A4JBS2
Q5WAG3
MNME_ALKCK
tRNA modification GTPase MnmE
Alkalihalobacillus
MEMDTIAAISTALGEGAIGIVRLSGDQAIAIGDKLFKGTKRLEDTPSHTIVYGHLMDDASEEAIEEAMVTVMRAPRTYTREDIVEINCHGGLVSVNRVLQAVLAKGARLAEPGEFTKRAFLNGRIDLSQAEGVIDLIRSKTDRAMNVALRQVEGRLSKKIGKLRQALLETIASIEVNIDYPEYDAETMTAKLINEKMTIVLAEIEALLATAKQGKVLREGLATAIIGRPNVGKSSLMNSLVHEAKAIVTDIPGTTRDTLEEYVNVRGVPLRLIDTAGIRETEDIVERIGVERSRQALKEADLILLVLNYAEKLSKEDEALFEAVKGLDVVVIVNKIDQTGRIDMERVRQLAGENPVVATSFLQEEGVDQLEEAISRLFFAGGVEGADLTYVSNARHIGLLNQAKAHAEEAIAASLTDVPVDLIQIDVTRTWELLGEIIGEDVQDSLIDQLFSQFCLGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q5WAG3
A1D4C8
PLPL_NEOFI
Patatin-like phospholipase domain-containing protein NFIA_019760
Aspergillus subgen. Fumigati
MTSDEKSATRDIYDPNTLPDYDREFIDPDDLRQFEKALNAPEAAPLVALNDWRPVNQRVRKSRRTKPRRSKDETREGVLYTVLKWPFLFTVFAWITVLGFAYTLTRLYIFLYEQFVTWRGKRERLRKELSMQTNYQDWLKAAQALDTYLGNLKWKETDEYAYYDHLTINKVVAQLKQTRKAAETEMQNGRSGLSDPPAVEELCFLLEACVKNNFAGVENPRLYSETYSGTKDLVQEYIDEVHSCIRLVLDSKQISNEDKYQFFKHLDTNFGRTALCLSGGATFAYYHFGVIRALLDNDVLPEIITGTSGGALVAALVATRTDEELKQLLVPALAHRIRACHEGFTTWVRRWWRTGARFDTLDWARQCSWFCRGSTTFREAYERTGRILNVSCVPSDPHSPTILANYLTSPDCVIWSAVLASAAVPGILNPVVLMTKKRDGTLAPYSFGHKWKDGSLRTDIPIKALNLHFNVNFTIVSQVNPHINLFFFNSRGSVGRPVTHRKGRGWRGGFLGSAIEQYIKLDMNKWLRVLRHLELLPRPLGQDWSEIWLQKFSGTITIWPKSIPSDFYHILSDPSPERLARMLHVGKQSAFPKIQFIKNRLKIENAIMQGLQQCSSGGGRVMSPILSRRRQDRAEEHADRMVERLDQSFPERQSDYKDESHYTEVSDSLSATSSRPHTPDARRSSMFEEMRRQSAVFFDDSDMYADEDAVTT
Probable lipid hydrolase.
A1D4C8
Q87S70
NCPP_VIBPA
Nucleoside-triphosphate phosphatase
Vibrio
MSKKIMATQKVVIASLNPAKINAVKSAFQSAFPQQVFEFVGISVPSEVADQPMTNEETHRGALNRVKNAKLEMPTADFYVGLEAGIEGNVTFAWMVIESDTHRGESRSASLMLPPEVLAQLADANELGDVMDKVFGTENIKQKGGAISLLTQNQLTRSSVYHQALILALIPFTNPDHFPANL
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Q87S70
P50242
ESR1_SALSA
Nuclear receptor subfamily 3 group A member 1
Salmo
SRMLTDPPRIGSMQSLGSSPTGPLVFVSSSPQLSPFLHPPGHHGLPSQSYYLETSSTPLYRSSVVTNQLSASEEKLCITSNRQQSYAAAGSGVRVFEMANETRYCAVCSDFASGYHYGFWSCEGCKAFFKRSIQGHNDYMCPATNQCTMDRNRRKSCQACRLRKCYEVGMVKGGLRKDRGGRVLRKDKRYCGPAGDREKPYGDLEHRTAPPQDGGRNSSSSSLSGGGGWCGPRITMPPEQVLFLLQGAEPPALCSRQKVARPYTEVTMMTLLTSMADKELVHMIAWAKKVPGFQELSLHDQVQLLESSWLEVLMIGLIWRSIHCPGKLIFAQDLILDRSEGDCVEGMAEIFDMLLATVSRFRMLKLKPEEFVCLKAIILLNSGAFSFCSNSVESLHNSSAVESMLDNITDALIHHISHSGASVQQQPRRQVQLLLLLSHIRHMSNKGMEHLYSIKCKNKVPLYDLLLEMLDGHRLQSPGKVAQAGEQTEGPSTTTTTSTGSSIGPMRGSQDTHIRSPGSGVLQYGSPSSDQMPIP
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
P50242
Q6WGK6
CXB1_HORSE
Connexin-32
Equus
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPIHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAAFMYVFYLLYPGYAMVRLVKCDAYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIVRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Q6WGK6
B3WAM4
RS12_LACCB
30S ribosomal protein S12
Lacticaseibacillus
MPTINQLVRQGRKSISTKSDSPALNFGYNSKKKSLTNNPAPQKRGVATRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVDGRMQGRSKYGAKRPKKK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
B3WAM4
A6WV17
RLMN_BRUA4
tRNA m2A37 methyltransferase
Brucella
MSISFDLTIDDTRDQLARHARASLEAKPSLIGMSREEMAEALIKAGVPERQVKMRISQLWHWLYVRGVSDFADMRNISKDLRAMLAQHFTIARPEVVEEQISQDGTRKWLFRFPPRGAGRPVEIESVYIPEEGRGTLCVSSQVGCTLTCSFCHTGTQKLVRNLTSEEILAQLLTARDRLGDFPDKDTPDGAMVPAEGRKITNIVMMGMGEPLYNFEEVKKALLIASDGDGLSLSKRRITLSTSGVVPEIYRTGDEIGVMLAISLHAVRDELRDILVPINKKYPLEQLIKACREYPGLSNAKRITFEYVMLKDINDSLEDAKLLVKLLQGIPAKINLIPFNPWPGTNYQCSEWEQIEKFADYVNAAGYASPIRTPRGRDILAACGQLKSESERMRKSERLALEAMMIAGHGE
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
A6WV17
C4LAS5
NIFH_TOLAT
Nitrogenase reductase
Tolumonas
MALRQCAIYGKGGIGKSTTTQNLVSALAEMGKKVMIIGCDPKADSTRLILHAKAQNTIMEMAAEVGSVEDLELEDVLQIGYGGVRCAESGGPEPGVGCAGRGVITAINFLEEEGAYEEDLDFVFYDVLGDVVCGGFAMPIRENKAQEIYIVCSGEMMAMYAANNISKGIVKYAKSGSVRLAGLICNSRQTDREDELIIALADKLGTQMIHFVPRDNIVQRAEIRRMTVIEYDPTCKQANEYRTLANKVVNNKLFVVPTPVTMDELEELLMEFGIMDVEDETIIGKTAAEEAAATA
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
C4LAS5
B8E0X9
RPOZ_DICTD
Transcriptase subunit omega
Dictyoglomus
MKEVNIDTLISKIPNKYVLTVVISKRARQLFEELKFLKTIARDPLILAMEEIAQEKIAYGEGDDLED
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
B8E0X9
Q5QVT4
CH60_IDILO
Chaperonin-60
Idiomarina
MAAKEVKFGNTARQKMLKGVNILADSVKVTLGPKGRNVVLDKSYGSPVITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDEAGDGTTTATVLAQAIVNEGLKSVAAGMNPMDLKRGIDKAVIAAVEELKKISQPCADSKAIAQVATISANADHTIGEIIAQAMDKVGQEGVITVEEGQALTDELDVVEGMQFDRGYLSPYFINNQESGSVELDNPFILLIDKKISNIRELLPVLEGVSKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTVVSEEIGMELEKTQLEDLGTAKRVVITKDNTTVVDGNGDDTAIDGRVNQIKQQMEDTTSDYDREKLQERLAKLAGGVAVIKVGAATEMEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRAASKLAELRGDNEEQNVGIRLALRAMEAPLRQIAMNAGAEGSVVANNVRAGEGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFAASVGALMITTEAMIADIPQDDNAGGMPGGDMGGMGGMGGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Q5QVT4
Q252V7
RS19_CHLFF
30S ribosomal protein S19
Chlamydia
MGRSLRKGPFVDHSLIKKVRAMNLLEKKAPIKTWSRRSMITPEMIGHTFEVHNGKKFLTVFVSETMVGHKLGEFSPTRMFKSHPVKKG
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Q252V7
A0A0B5AC95
INS1A_CONGE
Con-Ins G1a A chain
Gastridium
MTTSSYFLLMALGLLLYVCQSSFGNQHTRTFDTPKHRCGSEITNSYMDLCYRKRNDAGEKRGRASPLWQRRGSLSKLKARAKRNGAFHLPRDGRGVVEHCCHRPCSNAEFKKYCG
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock . It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form . Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=16.28 nM) . In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin . In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency . When tested on a mouse model of diabetes, this insulin also lowers blood glucose with a 10-fold lower potency than human insulin .
A0A0B5AC95
B2JDU4
MURB_PARP8
UDP-N-acetylmuramate dehydrogenase
Paraburkholderia
MSQPESLPFIADFPLKPHNTFGFDVRARLACRIETDAQLLAALRDPRAAGLRRLVLGGGSNVVLTGDFDGLVLLVALRGRKVVREDDEAWYVEAAAGENWHEFVSWTLAEGMPGLENLALIPGTVGAAPIQNIGAYGLEMCERFASLRAVELATGKLVELGAGACRFGYRDSFFKQEGRERFVIVSVTFRLPKVWAPRAGYTDIARQLAAVGLGDATPTPQAIFDAVVAVRRAKLPDPFVLGNAGSFFKNPVVESAQFDALAAKEPEIVSYRQADGRVKLAAGWLIDRCGWKGRTLGAAGVHERQALVLVNRGGASGTEVLALAKAIQQDVAQRFGVELEAEPVCL
Cell wall formation.
B2JDU4
P42949
TIM16_YEAST
Presequence translocated-associated motor subunit PAM16
Saccharomyces
MAHRAFIQVIITGTQVFGKAFAEAYRQAASQSVKQGATNASRRGTGKGEYGGITLDESCKILNIEESKGDLNMDKINNRFNYLFEVNDKEKGGSFYLQSKVYRAAERLKWELAQREKNAKAKAGDASTAKPPPNSTNSSGADNSASSNQ
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
P42949
Q6GDB4
PCP_STAAR
Pyroglutamyl-peptidase I
Staphylococcus
MHILVTGFAPFDNQDINPSWEAVTQLENIIGTHTIDKLKLPTSFKKVDTIINKTLASNHYDVVLAIGQAGGRNAITPERVAINIDDARIPDNDDFQPIDQAIHLDGAPAYFSNLPVKAMTQSIINQGLPGALSNSAGTFVCNHVLYHLGYLQDKHYPHLRFGFIHVPYIPEQVVGKPDTPSMPLEKIVAGLTAAIEAISNDEDLHLALGTTQ
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Q6GDB4
Q5U2V5
CRLS1_RAT
Cardiolipin synthase (CMP-forming)
Rattus
MLAWRVARGAWGSLRVAVRPPGARLGRGGSRRALLPPAACCLGCLAERWRLRPAAFALRLPGTSPRTHCSGAGKAAPEPAAGGDAAAQAPSARWVRASATSSYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQKSALGSALDPLADKVLISILYISLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCCTAFTTAASAYSYYHYGRKTVQVIKGK
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
Q5U2V5
Q9NEU5
NOP53_CAEEL
Ribosome biogenesis protein NOP53
Caenorhabditis
MVAGKRTGAAKGSRHNKKYWRKGTNIDDIEDSIHIKSRQAATGGVISEMKDEDLFIVDRTATANKPVVPKLTKKQQAALEKITKNITQEHVTLPKPSTTSKILKKPAKLPRGNAILALKKGPKAAAPAAKKKNFDVWTTDLTPKIPKSKLENQEAAEHFLKVVKKKQPKTPGKSITSLLPAVQIAEGGASYNPESAEYQEYVAKIAGEEQKLIDHEAKIKAGIEPQWEKVTTEHERFLEMAEGLRIHPKYGKDDEEEEEAGNSEKSMKTGGEAEPKSQRVECDRMTKEQKKKKAKAQKLDKEEKRRLEEKAKEQDSHNVYRTKQLHKELDEEEKQRHEESEVRKKEKLINKLTKRQQLGKGKFVDAEDPFLLQEELTGNLRQLKPQGHVLDDRMKSLQRRNMLPIGGDKEKRRIKNRLKSKVVEKRSAKNIVKGSRVI
May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.
Q9NEU5
Q5NZT6
LOLD_AROAE
Lipoprotein-releasing system ATP-binding protein LolD
Aromatoleum
MSEATNEPVLACEGLSKTFREGADALQVLDGVTLAVARGERIAIVGASGSGKSTLLHLLGGLDVPSAGAVRLHGRDFSRMSDAERGRVRNEALGFVYQFHHLLPEFSALENVAMPLYIRRMEREAANERAVAMLKEVGLGHRLDHAPGELSGGERQRAAIARALVTQPACVLADEPTGNLDRRTAQSVFDLMLSLNERLATSFIIVTHDEQLAGRAQRTLRLDDGRLA
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Q5NZT6
Q8VZS0
PNC2_ARATH
null
Arabidopsis
MGVDLDLESISEATSGAIGSLLSTTILYPLDTCKSKFQAEIRVRGQQKYRYLSDVFWEAISSGNVLSLYQGLGTKNLQSFISSFIYFYSYSYFKRLHSQRIGSKSIGTKANLLIAAAAGACTSVLTQPLDTASSRMQTSEFGKSKGLWKTLTDGSWGNAFDGLGISLLLTSNPAIQYTVFDQLKQNLLEKGKAKSNKDSSPVVLSAFMAFVLGAVSKSAATVITYPAIRCKVMIQAADDSKENEAKKPRKRIRKTIPGVVYAIWKKEGILGFFKGLQAQILKTVLSSALLLMIKEKITATTWILILAIRTLFVTKARLKSP
Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP. ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth. Required for the beta-oxidation reactions involved in auxin biosynthesis and for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis.
Q8VZS0
A4XQK5
GATB_PSEMY
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Pseudomonas
MQWETVIGLEIHAQLSTQSKIFSASATSFGAEPNTQASLIDLGMPGTLPVLNAEAVRMAVKFGLAIDAHIAPQNVFARKNYFYPDLPKGYQTSQMDHPIVGKGHLDITLEDGTVKRIGITRAHLEEDAGKSLHEDFHGMSGIDLNRAGTPLLEIVSEPDIRSAKEAVAYVKAIHALVRYLGICDGNMAEGSLRCDCNVSVRPKGQEAFGTRAEIKNVNSFRFIEKAINHEIQRQIELIEDGGKVIQETRLYDPNKDETRSMRGKEEANDYRYFPCPDLLPVVIEQSFLDEVRSQLPELPTQKRERFQSQYGLSTYDASVLSASREMAEYFEEVAKVCGDAKLAANWVMGELSSLLNKEGLEIEQSPVSAEHLGGMILRIKDNTISGKIAKMVFEAMAAGEGSADAIIESKGLKQVTDSGAIEAMLDEVLAANAEQVEQYRASDEAKRGKMFGFFVGQAMKASKGKANPGQVNELLKKKLEG
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
A4XQK5
Q9HIH2
PURA_THEAC
IMP--aspartate ligase
Thermoplasma
MVVPNGEGDKTAAVVGLQFGDEGKGKITDYLSGSYDVVVRFNGGTNAGHTVVTDEGTFKFHLLPSGSLRTSYVVLGSGMVIDPVALIPEIEIVRKINPALKIIISRNAHVVTKMHRQIDVEEEKIRSSLMIGTTAQGIGPTYEDKYARTGIRMVDISDIDLIKEKIETMYRMHSNLLANTEFSNLAKREEMAKEIYEAGIKLTGYLDYTEVAIDRLYSQGKRILFEGAQGVFLDPDFGFYPFVTSSNTISASVYTGTGFSLRKVNRIIGVAKAYVSKVGEGPFPTEITGDLAKQLRDLGGEYGTTTGRPRRVGWLDLPMLKYAVRIDDVDEIAITKVDTLGMLDTVKVCRQYLIDGKPIDYVPRDMNTIKKIEPVYDEFEGWGAISDSISGRKISIDQLPSKLVKYIKYIEDQVGKPIGIISMGKERNRTVRIIK
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q9HIH2
B9JVV3
RS4_AGRVS
30S ribosomal protein S4
Agrobacterium
MSKRASSKYKIDRRMGENIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYGDLREKQFRATYDEANRRKGDTSENLIGLLESRLDAIVYRAKFVPTVFAARQFVNHGHVSVNGVKVNIGSYRCKAGDVIEVRQKSKQLAIVLEATQLAERDVPDYIEVDHNKMVATFVRVPTLSDVPYAVIMEPQLVVEFYSR
With S5 and S12 plays an important role in translational accuracy.
B9JVV3
Q8FFG3
FADI_ECOL6
Fatty acid oxidation complex subunit beta
Escherichia
MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLRDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWSDGKLKEEVMTAFIPPYKQPLAEDNNIRGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMSDLTLIDMHEAFAAQTLANIQLLGSERFARDVLGRAHATGEVDDSKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAIVVEAE
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Q8FFG3
A4WMZ0
PSB2_PYRAR
Proteasome core protein PsmB 2
Pyrobaculum
MGEEVQIGATAVGIKAKDGVVLAAEKRVSYGFYTLSSAGRKVFVIDDKLAIASAGIIADMQSLARIVKINAKAYELETRKKPTVRSMAKLLSVIMFSRRYMPFFAEVLVGGVDEEGSHLIVMDPLGSLIEDNYAALGTGAKLAISVLDTGYREDITLQDAKKLAVKALKAAIERDPVSGGGIDLVLIDQTGAKEEEVKVQLLI
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
A4WMZ0
A8AV30
DEF_STRGC
Polypeptide deformylase
Streptococcus
MSVIEKLIKPAHLIDMRDIIREGNPTLRAVAEEVSFPLADEDILLGEKMMQFLHNSQDPVMAEKLGLRGGVGLAAPQLDISRRIIAVLLPNPEDENGNSPQEAYALKEVMYNPKIVAHSVQDAALADGEGCLSVDRDVPGYVVRHARVTVDYFDKNGEKHRVKLKGYKAIVVQHEIDHINGIMFYDRINETDPFAIKEGMLILE
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
A8AV30
Q57837
Y392_METJA
Site-2-type intramembrane protease
Methanocaldococcus
MNYSIRLFKIMGIPIELHITFILFLVVIIGLSIMNNSIFWAVLFILLFVSVVLHELGHSYVAKKYGVKIEKILLLPIGGVAMMDKIPKEGELRIGIAGPLVSFIIGIVLLIVSQFFDININGYPLLYTLSLLNLMLGGFNLIPAFPMDGGRILRAILSKKYGYLKSTKIAANIGKSLALIMLLFGLLSMNIILILVSLFVYFGAEQESRVVEVETIFKNIKAKDIMTPNPVYVTPDMSIEEFLDFMLKHKYFGYPVVENGKLVGCIGIGNIHKKEGTVRDYMEKPVVVSEDTDIKEILRKMANTDRVFVVEGGKLKGIISKTDILRAMSILELKEELKD
A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. Possible signals, S1P and substrates are unknown in this organism.
Q57837
Q1D0S8
MURD_MYXXD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Myxococcus
MTLALSGQKVLVFGLAKSGVAALRLLRQQGADVTALDARGEDALGAVAHEVKALGATRVSGPTPPGLLASQDLVVVSPGVPLALPEIQAARAAGVAVWGEVELAGRMLSGVPLFGITGTNGKSTTTALTGTLFASGDKRTFVGGNLGRPFSEAAMSPGDWDALVVELSSYQLEGIRTLRPRGAAILNLTPDHIDRYPSHAAYGEAKARIFQNQQAGDFVVVNADDADVLGLARAAKAPVYGFSLTGKPVADAPALAGLAVVEPGGFRLAFLGEHYTLTNRALRGAHNAQNAMAAALLARLGGVASGAVQAGLDGYPGLPHRLESVRVLDGVEWVNDSKATNVDSVLVALRAFSQGVWLIAGGKGKGAPYAPMVEAGQGKVKGVLTIGDDADTLARAYAGAAQVHACGTLAHAVARARELAERGDTVLLSPACASFDQFKNFEDRGDSFKRLVEAL
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q1D0S8
A0R3C7
GLMU_MYCS2
Glucosamine-1-phosphate N-acetyltransferase
Mycolicibacterium
MTASTEAAVVVLAAGAGTRMRSDTPKVLHTLAGRGMLAHVLHTVSEIDARHLVAVLGHDRERIAPEVARLSEELGRAIDVAVQDQQLGTGHAVNCGLTALPHDFAGMVVVTSGDVPLLDTATLTGLITSHGSGDAAATVLTTTLPDPTGYGRILRTQDHEIIGIVEQADATESQRTICEVNTGVYAFDIADLRSALTRLRSDNAQHELYLTDVVEILRQDHRTVRALHVDDSALVTGVNDRVQLSDLGKVLNRRIVAAHQRAGVTIIDPGSTWIDIDVQIGQDTVVHPGTQLLGATRVGSHCVIGPDTTLTHVTVGDGASVVRTHGSESVIGAGATVGPFTYLRPGTNLGADGKLGAFVETKNCTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGENKSRTTIGSHVRTGSDTMFVAPVTVGDGAYTGAGTVLRDDVPPGALAVSAGPQRNIEGWVAKKRPGSAADKAARKALGDES
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
A0R3C7
Q6NCM6
YBEY_RHOPA
Endoribonuclease YbeY
Rhodopseudomonas
MSQPRPGHRPDCNGADPDSNFASMTHSARPFTEVVIEADCWQAEASAEATVLRAIETAADAVDADTGGAELAVMLTDDDHIRQLNASFRGKDKPTNVLSFPAAQPEVQPDGAPRMLGDIAIAYQTVRREADDEGKPFDHHLSHLAVHGFLHLVGYDHETEEEAEEMEDAERAILARLGIPDPYAGQDRVS
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q6NCM6
P40614
MPCP_CAEEL
Phosphate carrier protein, mitochondrial
Caenorhabditis
MSVFSQLAESSKQNPFSLPVRSGNCASAVSAPGQVEFGSGKYYAYCALGGVLSCGITHTAIVPLDLVKCRIQVNPEKYTGIATGFRTTIAEEGARALVKGWAPTLLGYSAQGLGKFGFYEIFKNVYADMLGEENAYLYRTSLYLAASASAEFFADILLAPMEATKVRIQTSPGAPPTLRGCAPMIYKAEGLTGFYKGLPPLWMRQIPYTMMKFACFEKTVEALYQYVVPKPRAECSKAEQLVVTFVAGYIAGVFCAIVSHPADTVVSKLNQDSQATAGGILKKLGFAGVWKGLVPRIIMIGTLTALQWFIYDSVKVALNLPRPPPPEMPASLKAKLAAQQ
Transport of phosphate groups from the cytosol to the mitochondrial matrix.
P40614
Q8LPN5
AHL12_ARATH
AT-hook motif nuclear-localized protein 12
Arabidopsis
MDGREAMAFPGSHSQYYLQRGAFTNLAPSQVASGLHAPPPHTGLRPMSNPNIHHPQANNPGPPFSDFGHTIHMGVVSSASDADVQPPPPPPPPEEPMVKRKRGRPRKYGEPMVSNKSRDSSPMSDPNEPKRARGRPPGTGRKQRLANLGEWMNTSAGLAFAPHVISIGAGEDIAAKVLSFSQQRPRALCIMSGTGTISSVTLCKPGSTDRHLTYEGPFEIISFGGSYLVNEEGGSRSRTGGLSVSLSRPDGSIIAGGVDMLIAANLVQVVACSFVYGARAKTHNNNNKTIRQEKEPNEEDNNSEMETTPGSAAEPAASAGQQTPQNFSSQGIRGWPGSGSGSGRSLDICRNPLTDFDLTRG
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Q8LPN5
F4ZGF2
COMTA_DANRE
Catechol O-methyltransferase A
Danio
MLWVVLAVVVVLASVLVLLRQSSGLLALLWHDVVHQRLLNFFTGLSRPQRILKAVQKNATKGNPESVIAAIDHYCRHSEWAMNVGDEKGLILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGTKLITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQQHGIKSFDFVFLDHWKDRYVPDTKLLEECGLLRKGSVLLADNVICPGTPEYLKYVRNDPRYESRYFKSNLEYTKVEDGLEKSVFLG
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Shows highest activity towards catecholestrogens and dobutamine. Also has lower activity towards L-DOPA, dopamine and epinephrine. Active towards the xenobiotic compounds methyl-DOPA, carbidopa, isoproterenol, and apomorphine.
F4ZGF2
P25312
COX2_SYMSY
Cytochrome c oxidase polypeptide II
Symphalangus
MAHAAQMGLQDATSPIMEELISFHDHALMIIFLISFLVLYALFLTLTTKLTNTNITDAQEMETVWTILPAIILVLIALPSLRILYLTDEINDPSFTIKAIGHQWYWAYEYTDYGGLIFNSYMLPPLFLEPGDLRLLEVDNRVVLPIEAPVRMMITSQDVLHSWTVPSLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P25312
Q63H62
ECFA1_BACCZ
Energy-coupling factor transporter ATP-binding protein EcfA1
Bacillus cereus group
MKKEKLRTENISFQYPGAATYALKDVSFSLFEGEWVSVIGQNGSGKSTLAKLLNGLFLPEAGTITVNDTMILSEETVWDVRKQIGMVFQNPDNQFVGTTVQDDVVFGLENIGMPREQMVERLNQALRLVRMEDFLNDEPHSLSGGQKQRVAIAGVLALQPSILILDEATSMLDPQGRREVVETVRQLVNEKGITVLSITHDLEEAAQSDRVIILNKGEILEEGIPEQIFKSSHMLQEIGLDVPFSVKIAELLKRNEILLQNTHLTMESLVNELWRLHSKK
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q63H62
C1F638
RS19_ACIC5
30S ribosomal protein S19
Acidobacterium
MARSTKKGPFIDGHLMVKIEAMNQANDRKVVRTWSRRSTVHPDMVGHTIAVHNGKKFVPVYVTENMVGHKLGEFAPTRTFKGHAAKTESSSRAR
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
C1F638
O03890
COX2_CASBE
Cytochrome c oxidase polypeptide II
Casuarius
AICSLVLYLLTLMLMEKLSSNTVDAQEVELIWTILPAIVLILLALPSLQILYMMDEIDEPDLTLKAIGHQWYWTYEYTDFKDLSFDSYMVPTSELPSGHFRLLEVDHRVVVPMESPIRVIITAGDVLHSWAVPTLGVKTDAIPGRLNQTSFITTRPGIFYGQCSEICGANHSYMPIVVESTPLTHFENWSSLLSISSSL
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
O03890
B8ZR59
RNPH_MYCLB
tRNA nucleotidyltransferase
Mycobacterium
MSTRADGRLDDELRAVVITRGFTEHPAGSVLIEFGHTKVMCTASPTEGVPRWRKGSGKGWLTAEYAMLPSATHTRSERESVKGRLSGRTQEISRLIGRSLRACIDLAALGENTIAVDCDVLQADGGTRTAAVTGAYVALADAVTYLSAAGRLLDPRPLSCAIAAVSVGVVDGRIRVDLSYEEDSRAEVDMNVIATDTGTLVEIQGTGEGATFPRSTLDKLLDMALGACDKLFVAQRDALALPYQGMSPEGPPPPKAFGS
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
B8ZR59
A5UZQ2
IF2_ROSS1
Translation initiation factor IF-2
Roseiflexus
MSDMQISGYQSAINARHYIQFAGGGRGPGNPGGGRGPGNPGGGRGPGSPGGGRGPGSPGGGRGPGSPGGGRGPGNPGGGRGPGGGRGGGRGGDGRRRDESFVENEGGRGNRSGRTTSTATTARTPGGLARPTTTVRAPVRPKGPIALPVTMTVREFSEATGVGASEILKALLKAGVVANINQQIDYETAAVIAADFGIETVEYVPPQLEGVVENIRDVLAAQDPKDMKPRPPVVTIMGHVDHGKTKLLDAIRSTRVAESEAGGITQHIGAYQVELHGRKITFLDTPGHEAFTAMRARGAQVTDIVVLVVAADDGVMPQTLEAISHVKAAGVPMIVAINKIDAPNANPDRVRQQLANAGVIVEQFGGDVPSVEVSAKLKKNIDGLLEIILLVADLNEYKANPNAPAVGTIIEAEMDRTRGPVATVLVQNGTLRLEDNVLVGSTTGTIRTMFNDAGKRLRFAEPATPVVILGLHDVPQAGDILQVMPDLAVAREIALQRQRKQRLEAMATSRGVSLDGLFSSIQQGKIKELNIILKADVQGSIGAIEHALSQLNTDEVQIRIIHRGTGTITESDVNLAIASHAIIIGFNARPDPAARRQAEQYGVDIRFYNIIYQLTEDIKKAMIGMLEPEYREVTEGFAEVRNTFRLPTREIVAGLYVTEGKISRQYNVRVLRNGVVLHDGKIASLKRFKDDVREVQAGYECGLIVEGFNDITPGDTMEFYRRERVERTV
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A5UZQ2
Q1BLQ3
CHEB3_BURCA
Protein-glutamate methylesterase/protein-glutamine glutaminase 3
Burkholderia cepacia complex
MNIGIVNDLPLAVEALRRVIALRADHRVLWVATDGDEAVDFCVAHPPDVVLMDLVMPKVDGVAATRRIMARAPCAILIVTASVSANTSSVYEAMGAGALDAVDTPTLALGLSTDASPQALLAKIDQIGRLLESRTTALVPPGPAPTRGQPTLVAIGASAGGPTALTALLRALPADFPAAIVIVQHVDQAFAYGMAEWLDGYTRLPVRVARQGSVPEAGAVLLAATNDHLMLSPRGVLGYTRHPAETPYRPSIDVFFNSVADGWQGDALGVLLTGMGRDGALGLKAMRAKGCYTIAQDQATSAVYGMPKAAAAIGAASAILPLDQIAPQLIARIALTSRD
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q1BLQ3
Q49Z29
CSHA_STAS1
DEAD-box ATP-dependent RNA helicase CshA
Staphylococcus
MQNFKELGISDKMAETLQSMGFNEATPIQKESIPLALEGKDVLGQAQTGTGKTGAFGIPLIEKVADQEGVQSLILAPTRELAMQVAESLKAFAKGQNIQVVTVFGGMPIDRQIKALKKGPQIVVGTPGRVIDHLNRRTLKTNDIHTLILDEADEMMNMGFIDDMKFIMDKIPAEQRQTMLFSATMPKAIQTLVQQFMKSPVIVKTMNNEMSDPQIEEYYTIVKELEKFDTFTSFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQLDILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKKGVAITFVNPIEMDYIRQIEQANKRQMTALRPPHRKEVLKARENDIKGKVQNWMSRDNEPRLQRIATELLGEYNDVDLIASLLQELVESNDEVDVQLTFEKPLSRGKGRQGKGGPKRGGNHKRGGGKFDNKNRRSGKGGFNNKKKNDRPSSDRNNNKKSMKGRTFADHKK
DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
Q49Z29
C0ZXR9
RIMM_RHOE4
Ribosome maturation factor RimM
Rhodococcus erythropolis group
MELVVGRVAKSHGIKGELVVEVRTDEPEDRFAVGSVLRGRKPRESTLKSYTVEAARDHSGRLLLRLEGVSDRGDADALRGTLFVIDSSELEPSDDPDEFYDHELEGLKVVLTDGTEVGSVIEVLHSAAGELLSIRRTGETSGELLIPFVAAIVTSVSIADGVVMIEPPEGLLDPDFGDKSNSDNSNSDND
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
C0ZXR9
Q40301
FCPE_MACPY
Fucoxanthin-chlorophyll a-c binding protein E, chloroplastic
Macrocystis
MAIACAAAPGLRGAEPFNGAALATSAKSSSAMKMSFESEIGAQPPIGFWDPLGLVADADQERFDRLRYVEIKHGRIAMLAVVGHITQQNTRLPGMLSFKENLAFADSPNGVAAFSKIPPLGTLQIILAIGCHELFVVKQVEGSFPGDCTTGGNIFQSAWDNMSEETQASKRAIELNNGRAAQMGILAMMVHEQLSNQPYIINDLAGAAYQFN
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Q40301
Q1GTA2
PYRE_SPHAL
Orotate phosphoribosyltransferase
Sphingopyxis
MTDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPRELKQAIDLVVSPAMGGVIIGHEMGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVVTTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVPFYPLVAINFPTYAADELPPELAGTEAIKPGSRSVAA
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Q1GTA2
A7GW12
RF1_CAMC5
Peptide chain release factor 1
Campylobacter
MFADKLRPFLDRYNEISALLGDPNIINDIEKMTKLSKEQSSIEPIKNAASQYLQTLDDIEENKALLDDAELGELAREELKSAQIRKEELENEIKILLLPKDPNDDKNIFLEIRAGTGGDEAALFVGDLFNAYIRYADLRGYKFEIVSQSEGSAGGFKEIILLIKGKGAYSRLKFEGGTHRVQRVPETESQGRVHTSAVTVAIMPEVEDSEIEINPNDLRIDVMRSSGHGGQSVNTTDSAVRITHIPTGLVVTNQDGKSQHKNKEAAMKVLKARLYEMQEAERIAKETSERKSQVGTGDRSGRIRTYNFPQNRISDHRINLTLYRLDAIMAGGLFDEIIEPLIAHHQAEAITDAGL
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
A7GW12
A1RWR7
RL18_THEPD
50S ribosomal protein L18
Thermofilum
MARGARYRVPLKRRREGKTNYYKRRKLIISGKPRLVVRVLSRTAIVQIAKATPKGDVVIASAHSNELKKYGWKGYRRNTPALYLLGFLAAKKALKQGVTEAIVDIGLHRPVKASRVFAAVKGALDAGLKIPVGDGVLPEDDRVRGEHIANYAKMLKESNPELFKLRFSGYLSAGLDPESLPEHFDSVKQKIEEALQ
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
A1RWR7
A6VKC5
RPOB_ACTSZ
Transcriptase subunit beta
Actinobacillus
MGYSYTEKKRIRKDFGKRSQVLNVPYLLTIQLDSFDKFIQRDPDGQQGLEAAFRSVFPIVSNNGSTELQYVSYKLGEPVFDVRECQIRGTTFAAPLRVKLRLVSYDKDAAPGTVKDIKEQDVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFARIDRRRKLPATIILRALNYTTEEILDLFFDKVVFEIQGDKLLMELVPERLRGETATFDIEAEGKVYVERGRRITARHIKALEKDGVKKVEVPTEYIIGKVAAKDYVDLESGEVICAANTEISLELLAKLAQAGYTAIEALFTNDLDFGPYISETLRVDPSCDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSQERYDLSAVGRMKFNRSLGIDSETGSGVLSKEDIVSVMKKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLDAVTPQDLINAKPISAAVREFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANANLDDDFRFTDTFVTARGEHGESGLYRPEEIHYMDVSTQQVVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPIALDSGVAVVAKRGGTIQYVDASRIVVKVNEDETIPGEAGIDIYNLIKYTRSNQNTCINQIPCVNLGEPVGRGEILADGPSTDLGELALGQNIRVAFMPWNGYNFEDSMLVSERVVQQDRFTTIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYVGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGTSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLVEELEILEAGLFSRVRNLLVDGGISEKELDTMERAKWLEQTLSSESKQSRLEQLAEQYEELRKDFEHKLEVKRSKIIQGDDLAPGVQKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGRPVEIVLNPLGVPSRMNIGQILETHLGLAAKGIGEQINIMLKQKQDIEKLRGYIQKAYDLGGGSQVVDLNTFTDEEVLRLAENLRKGMPLATPVFDGADESEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVGGTHYMEPGTPESFNVIMKEIRSLGLNIDLDEA
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A6VKC5
B2T1N9
HSLV_PARPJ
ATP-dependent protease subunit HslV
Paraburkholderia
MEQFHGTTIVSVRRGDKVALGGDGQVTLGNIVMKGGAKKVRRIYNGKVLVGFAGGTADAFSLLDRFEAKLEKHQGNLTRAAVELAKDWRTDRMLRRLEAMLITADATTTLVITGNGDVLDPEGGICAIGSGGAYAQAAATALAHNTELSPREIVEKSLEIAGDMCIYTNHNRVIETIE
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
B2T1N9
Q318I8
RS19_PROM9
30S ribosomal protein S19
Prochlorococcus
MGRSLKKGPFIADSLLKKVEKQNTDNDKSVIKTWSRASTILPLMIGHTIAVHNGKTHIPVFITEQMIGHKLGEFAPTRTYRGHIRDKKGAKS
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Q318I8
A5GI59
PSAC_SYNPW
PsaC
unclassified Synechococcus
MSHAVKIYDTCIGCTQCVRACPLDVLEMVPWDGCKAGQIASSPRTEDCVGCKRCETACPTDFLSIRVYLGDETSRSMGLSY
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
A5GI59
P00468
NIFK_NOSS1
Nitrogenase component I
Nostoc
MPQNPERTVDHVDLFKQPEYTELFENKRKNFEGAHPPEEVERVSEWTKSWDYREKNFAREALTVNPAKGCQPVGAMFAALGFEGTLPFVQGSQGCVAYFRTHLSRHYKEPCSAVSSSMTEDAAVFGGLNNMIEGMQVSYQLYKPKMIAVCTTCMAEVIGDDLGAFITNSKNAGSIPQDFPVPFAHTPSFVGSHITGYDNMMKGILSNLTEGKKKATSNGKINFIPGFDTYVGNNRELKRMMGVMGVDYTILSDSSDYFDSPNMGEYEMYPGGTKLEDAADSINAKATVALQAYTTPKTREYIKTQWKQETQVLRPFGVKGTDEFLTAVSELTGKAIPEELEIERGRLVDAITDSYAWIHGKKFAIYGDPDLIISITSFLLEMGAEPVHILCNNGDDTFKKEMEAILAASPFGKEAKVWIQKDLWHFRSLLFTEPVDFFIGNSYGKYLWRDTSIPMVRIGYPLFDRHHLHRYSTLGYQGGLNILNWVVNTLLDEMDRSTNITGKTDISFDLIR
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
P00468
Q5RBD9
TBCE_PONAB
Tubulin-folding cofactor E
Pongo
MSDTLTADVIGQRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFQCRHPTGGSFIRPNKVNFGTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRNCAVSCAGEKGGVAEGCPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSGSVLTGTLSALKVLVLNQTGITWAEVLRCAMGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLIDENQLYLIAHLPRLEQLILSDIGISSLHFPDAGIGCKTSLFPSLKYLVVNDNQISQWSFFNELDKLPSLRALSCLRNPLTKEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPDKNRLSEEFLTAHPRYQFLCLKYGAPEEWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVKGLLSRLLKVPVSDLLLSYESPQKPGVEIELENDLKSLQFYSVENGDCLLVRW
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
Q5RBD9
A5UBP1
UPP_HAEIE
UPRTase
Haemophilus
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGPVEIDRIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASDLEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLVAAPEGIKALEAAHPDIELYCASIDSHLNEQGYIIPGLGDAGDKIFGTK
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
A5UBP1