accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q75D88
SET1_ASHGO
SET domain-containing protein 1
Eremothecium
MSGYYNHVKHQGYSRYGQNSTVRNGQHDGLRYRNPSPAHNGTNEGEGLQGSRYENAGGVTHARRPPPVVKWGEAAFRAKYHYFDVEERKLLHLDEMKHWQNGRLPANGYVLVADAGSKGRPVMRERNPEEQAVDPRGARAAHTVRRVRSLLTALPRIPYDAHWVGPEPPKEVVVFPKQREQALSVQDPIIKNFFGTFGEVAHFESFNDPNNALPLNIYLVRYINVEGNPDSPYKAAYKAVKQFAKQDYLVSGARFAVRLNMNGFLQKTIDKFVTENLQRAAKLRHEQAKQQSTVQKVTNVSAVPSGVPPPKIPLGLERIVNNKPILRVSARFCALHGITSEDFKYGLKNYHWTRVINHYSGIYIIFDDIAEAEKCLQMESLRLTFFSRRRKIPVKIKFMLIEPSHQPPASQPLTDQDEVPKVYETEAELIEETLKHIINELKTTLYKDIRRRLLGPTIFDALNPGNYPDIVARRQKEEEAKKEKEKAMVEKTKKEAPSAAAFDIFNLYGTAYKKRDGTKGKKRHVAEGRPEESSGRRRIQSKGTAPMAHMLNYESLKVNGTASPIKEAESETCSSDEEDDDNFDVEMTDQSSIKKLKRESTATTPEQEPLQERVAGLSAERTKELLSYPEKYRPLAGDQPEPIYPEFLIEKYDDPLLSIVDLQRSVKDKEDMELLKKVIAYDREEVKDVINDIEFFAWRLHRDYKEHKENMQHQSKLSESTYKNLLNAHGGCFKQQGFRKMPDKLKSIYLPHRRKLNQPLNTVYHHGIEDFANTDNNKMDTDPPEDTFTPEQTSSRVNRALQRRFQQDIEAQKAAIGTESELLSLNQLTKRKKPVTFARSAIHNWGLYALEPISAKEMIIEYVGERIRQPVAEMREKRYLKSGIGSSYLFRVDESTVIDATKKGGIARFINHCCDPSCTAKIIKVGGMKRIVIYALRDIAANEELTYDYKFERETDDEERLPCLCGAPNCKGFLN
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Q75D88
A4W9J6
ASTA_ENT38
AOST
Enterobacter
MMVIRPVERGDLAGLMQLAGKTGGGLTSLPADEKTLSSRIDRALQTWQGTLPKSEQGYVFVLEESDTGTVVGICAIEVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDRFNEKVVAEMRGVIDETGYSPFWESLGERFFSMEFSRADYLCGTGQKAFIAELMPKHPIYTDFLSPQAQAVIGQVHPQTAPARAVLEKEGFRYHNYVDIFDGGPTLECDVDRVRAIRKSRLVTVAEGQPAPGEWPACLVANEQYDQFRAMLIHTNPTCERLVLTAAQLDVLKCNAGDTVRLVRLCPEEKTA
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
A4W9J6
A7E5J5
EIF3L_SCLS1
Eukaryotic translation initiation factor 3 subunit L
Sclerotinia
MSAFQNGGIASRALDDDSDIEEEALANDYKEQVQYEGMEELEQVNSMSMAQQTDDIQSRLAAAAQPLDFSAPLEVKFASYDNYCSLFHFILNSDGPVDLEPPSYYWAWDVIDEFIYQFNSFCSYRNRVARQGTNEEEIQILREAPNTWGCYSVLNVLYSLIQRSQINEQLAAMRRNEEPMAVAGDYGSKSLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILIYVSRTKNFQKNAQYDSISKKNDQMYALIAICVAFHPTRLDDTIHTALREKYGDQLLKLQRGGPESLPIFEELFRSACPKFISPTPPDFDNPELNVDPLEHHLSIFMDEVKTNMWSPTVKSYLRLYTTMDLKKLAGFLEVEPEKLRGWLLVNKQRSRQIRWTDNGLLDGEVVNSNDLDYAMQGDLIHISEAKVGRKLVDWYLRNLARTY
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
A7E5J5
Q82DQ7
RL10_STRAW
50S ribosomal protein L10
Streptomyces
MARPDKAAAVAELADQFRSSNAAVLTEYRGLTVAQLKTLRRSLGEDAQYAVVKNTLTKIAANEAGINTLDDLFNGPTAVAFITGDPVVSAKGLRDFAKDNPNLVIKGGVLDGKALSADEIKKLADLESREVLLAKLAGAFKGKQSQAASLFQALPSKFVRTAEALRAKKAEQGGAE
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Q82DQ7
P12660
PCP2_MOUSE
Purkinje cell-specific protein L7
Mus
MAGSPDQEGFFNLLTHVQGDRMEEQRCSLQAGPGQNPESQGGPAPEMDNLMDMLVNTQGRRMDDQRVTVNSLPGFQPIGPKDGMQKRPGTLSPQPLLTPQDPAALSFRRNSSPQPQTQAP
May function as a cell-type specific modulator for G protein-mediated cell signaling.
P12660
Q8ZCH3
NANT_YERPE
Sialic acid/H(+) symporter
Yersinia
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFISRWFGGLVLGAMGDRYGRKLAMITSIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASGFLISGFSIGAVLAAQAYSYVVLAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHLSYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLKMDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGIAGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVRPSGLRMVDAIDGKPFSGAITAQHARVVTQK
Catalyzes the proton-dependent transport of sialic acid.
Q8ZCH3
A3PLD1
TYSY_CERS1
Thymidylate synthase
Cereibacter
MAHPEQQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSDGQVPILTTKRVYWKTAVKEMLWFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRILEDEAFAARWGELGPVYGRQWRRWLGPDGREHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQYHVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLNHLDQAREQTGRAPRDWPRMRLLRQADGIDDYRIEDFAVEGYDPHPAIAAEVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
A3PLD1
Q5E960
S39A3_BOVIN
Zrt- and Irt-like protein 3
Bos
MVKLLVAKILCMVGMFFFMLLGSLLPVKIIEMDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLKEVLTLAHISTDYPLAETIMLLGFFMTVFLEQLVLTFRKERPAFIDLETFNASSDAGSDSEYESPFMGGPRGHALYAEPHGHSHGLSVQELSRSSPLRLLSLVFALSAHSVFEGLALGLQEEGEKVVSLFVGVAIHETLVAVALGINMARSAMALRDAAKLAVTVSAMIPLGISLGLGIESAQGMPSSVASVLLQGLAGGTFLFVTFFEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFIKW
Acts as a zinc-influx transporter.
Q5E960
P17953
ASA1_ENTFA
Aggregation substance
Enterococcus
MKQQTEVKKRFKMYKAKKHWVVAPILFIGVLGVVGLATDDVQAAELDTQPGTTTVQPDNPDPQVGSTTPKTAVTEEATVQKDTTSQPTKVEEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSPETTNEPLGQPTEVAPAENEANKSTSIPKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDQLQKEQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKERYEKEVAEYNKHKNENGYVAKPVNKTLIFDREATKNSKVVSVKAAEYIDAKKLTDKHKDKKLLISMLSVDSSGLTTKDSKKAHFYYNNGAGGTLVVLHKNQPVTITYGNLNASYLGKKIASAEFQYTVKATPDSKGRLNAFLHDDPVATIVYGINIDPRTKKAGAEIEMLVRFFGEDGKEILPTKENPFVFSGASLNSRGENITYEFVKVGNTDTVHEINGSKVARHGNKVYSKTDIDVGTNGISISDWEAVQGKEYIGATVISTPNRIKFTFGNEIVNNPGYDGNSMWFAFNTDLKAKSITPYQEKGRPKQPEKATIEFNRYKANVVPVLVPNKEVTDGQKNINDLNVKRGDSLQYIVTGDTTELAKVDPKTVTKQGIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLHLDQNTVTAMMKTNADDSVVLAMGYKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPGSNPSKDVKADKNGTVGSVSLHDKDIPLQTKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDISAYILLENKDNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVERIKTGDVENTQTENYNKELVRSNTVVTHTPDDPKPTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKVTPIKDLLRVKDSKGEDITNQFTISWDDAKGTVTISAKDPQAFILAHGGQELRVTLPTKVKANVSGDVYNLAEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGIVEEWSISDKLDVKHDKFSGQWSVFANSTFVLADGTKVNKGDDISKLFTMTFEQGVVKITASQAFLDAMNLKENKNVAHSWKAFIGVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPPEKTVIVPPTPKTPQAPVEPLVVEKASVVPELPQTGEKQNVLLTVAGSLAAMLGLAGLGFKRRKETK
Aggregation substance allows donor and recipient strains to form tight aggregates which allow the non-motile bacteria to maintain physical contact over a period of time sufficient to permit conjugative transfer of the sex pheromone plasmid from donor to recipient strains.
P17953
Q9LEW3
AED1_ARATH
Apoplastic EDS1-dependent protein 1
Arabidopsis
MSIMRNFLSMIIMLCVCLNWCFAEGAEKSDSGKVLDSYTIQVSSLFPSSSSCVPSSKASNTKSSLRVVHMHGACSHLSSDARVDHDEIIRRDQARVESIYSKLSKNSANEVSEAKSTELPAKSGITLGSGNYIVTIGIGTPKHDLSLVFDTGSDLTWTQCEPCLGSCYSQKEPKFNPSSSSTYQNVSCSSPMCEDAESCSASNCVYSIVYGDKSFTQGFLAKEKFTLTNSDVLEDVYFGCGENNQGLFDGVAGLLGLGPGKLSLPAQTTTTYNNIFSYCLPSFTSNSTGHLTFGSAGISESVKFTPISSFPSAFNYGIDIIGISVGDKELAITPNSFSTEGAIIDSGTVFTRLPTKVYAELRSVFKEKMSSYKSTSGYGLFDTCYDFTGLDTVTYPTIAFSFAGSTVVELDGSGISLPIKISQVCLAFAGNDDLPAIFGNVQQTTLDVVYDVAGGRVGFAPNGC
Aspartyl protease involved in a homeostatic feedback mechanism regulating systemic immunity. Has only mild or no influence on local defenses. Acts downstream of salicylic acid to suppress systemic immunity.
Q9LEW3
Q9LH85
RLA23_ARATH
60S acidic ribosomal protein P2-3
Arabidopsis
MKVIAAFLLAKLGGNENPTSNDLKKILESVGAEIDETKIDLLFSLIKDHDVTELIAAGREKMSALSSGGPAVAMVAGGGGGGAASAAEPVAESKKKVEEVKDESSDDAGMMGLFD
Plays an important role in the elongation step of protein synthesis.
Q9LH85
Q7VRV9
NUOI_BLOFL
NDH-1 subunit I
Candidatus Blochmannia
MMKLKEFFINIISIFRSVYMVGMQAFSKRETYMYPDVACKLSSRYRGRIVLTRDSAGHERCVACNLCAVSCPVGCISLKKSENSEGRWYPEFFRINFSRCIFCGMCEEACPTAAIQLISDFEMSDYKRSDLVYEKSDLLISGPGKYKNYDFYQISGVKYSNKYKKESSFEEKPISVKTILP
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q7VRV9
B2FRM5
QUEC_STRMK
Queuosine biosynthesis protein QueC
Stenotrophomonas maltophilia group
MKKAVVLLSGGMDSAAVIAMAQEQGFAVHALSVRYGQRHTSELDAAARVAKAQGVVAHKIVDVDLRSIGGSALTDDIDVPEAGGAGIPVTYVPARNTIMLSLALGWAEVLGANDIFCGVNAVDYSGYPDCRPEFVAAFQALANLATKSGVEGAGIKVHAPLQFLSKGQIVSEGVRLGVDFGLTVSCYNADANGAACGHCDACRLRAQGFAEAGVPDPTLYA
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
B2FRM5
A8FJG3
RNPA_BACP2
Protein C5
Bacillus
MKKRNRLKKNEEFQKVFKKGQSMANRQFVIYQLDQPNQDELRLGLSVSKKIGNAVMRNRIKRLIRQVFLEEGHKLKQEKDYIVIARKPASELTFEETKKSLQHLFRKSAVYQQQPKKSS
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
A8FJG3
Q5P089
LEPA_AROAE
Ribosomal back-translocase LepA
Aromatoleum
MQHIRNFSIIAHIDHGKSTLADRLIHFCGGLSDREMEAQVLDSMDLERERGITIKAQTAALHYKAKDGQVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIEQNVEVVPVLNKIDLPAADPESARKEIEDVIGVDASEAVLCSAKTGLGIEDVLETVVRRVPPPKGDPDAPLKALIIDSWFDNYVGVVMLVRVVDGVLKPKDRILLMANGAQYPCDQVGVFTPRSVARPQLSAGEVGFIIAGIKELQAAKVGDTVTLAMRPASEPLPGFKEIKPQVFAGLYPVESSEYDQLRDSLEKLRLNDASLQYEPEVSQALGFGFRCGFLGLLHMDIVQERLEREFDMNLITTAPTVVYEVVMNSGEVIRVENPAKLPDQSKIAEIREPIITATIFLPQDYVGPVITLCNLKRGAQVDMRYHGRQVQLIYDLPMNEVVMDFFDKLKSVSRGYASLDYEFKEYRAADLVKLDLLVGGEKVDALSVIVHRASAQYRGREVAAKLRGLIPRQMFDVAIQSAIGSHIVARETIKALRKNVLAKCYGGDISRKKKLLEKQKEGKKRMKQVGNVEIPQEAFLAVLRVDEGK
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
Q5P089
Q21WX7
LPXB_ALBFT
Lipid-A-disaccharide synthase
Rhodoferax
MANQISQHLQVALVAGETSGDLLAGLLLDGLREQWPLMTAVGIGGPQMARRGLVAWWGHDKLSVHGFGWEVLRRYREIVGIRRQLKTRLLRQQPDVFIGVDAPDFNLDLEQDLKAQGIKTVHFVSPSIWAWRPERVEKIRRSVDHVLCIFPFEPALLARHGIAATYVGHPLANVIPMEPDRSAARAALGLADGDQVVAILPGSRQSEINHLALRFFQAAALINKAHPAIKFIVPAIPALRAGIEHAARASGMQAHLQIIAGQSHTVLAACDVTLIASGTATLEAALFKRPMVIAYRMGWLSWQIMRRKQLQPWVGLPNILCQDFVVPELLQDAATAQALADAVLLWIDAKASHPAKIAALQQKFTALHTELQRDTPRLAAHAIQQVLQG
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q21WX7
Q0I1J8
TRMD_HAES1
tRNA [GM37] methyltransferase
Histophilus
MWIGIISLFPEMFKAITEYGVTGRAVRQNLLEIQYWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHCAKSVAGDGVKVIYLSPQGRKLDQNGVQELARNQKMIFVCGRYEGIDERLIETEIDEEWSIGDYVLTGGELPAMTLIDAVARFVPCVLGKQASAQEDSFAEGLLDCPHYTRPEQLNGLTVPPVLMSGNHEEIRKWRLKQSLQRTWLRRPELLESLALTDEQSKLLSQIKQENS
Specifically methylates guanosine-37 in various tRNAs.
Q0I1J8
A8GMY3
MNMA_RICAH
tRNA-specific 2-thiouridylase MnmA
spotted fever group
MINLGDKHSTIVVAMSGGVDSSAVAAMLHEQGHNVIGITLQLYDHGMAVGKKNACCAGQDIYDAKMVANKLGIPHYVLDYESKFKESVIDNFVDSYLQGETPLPCVQCNNSVKFRDLIKTARELGASQLATGHYVRKVSGDNGVELHTGLDPAKDQSYFLFTTTKEQLEYLSFPLGWFTKDETRKLASKFGLEVAYKPDSQDICFVPDGNYKSVINTIRPNASESGKIIHINGFALGEHSGIINYTIGQRRGLGIAYNEPLYVVKIDPKDNIVYVGPEAALHVQEFIIKDVNWLADEIKDNKKLEVAVKIRSTRPPRLAAISKLGDDKMKIRFLSAEKAVAPGQACVIYAGERVLGGGWITRDIR
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
A8GMY3
A2YXU2
PSA7A_ORYSI
20S proteasome subunit alpha-4-A
Oryza sativa
MARYDRAITVFSPDGHLFQVEYALEAVRKGNAAVGVRGTDTVVLGVEKKSTPKLQDSRSMRKIASLDTHIALACAGLKADARVLINRARVECQSHRLTVEDPVTVEYITRYIAGLQQKYTQSGGVRPFGLSTLIVGFDPYTEKPALYQTDPSGTFSAWKANATGRNSNSMREFLEKNYKDTSGKETIKLAIRALLEVVESGGKNIEIAVMTHKDGLRELEEAEIDEYVAEIEAEKAAAEAAKKGAPKET
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
A2YXU2
P0DSK3
TX17A_MYRGU
U-myrmeciitoxin(01)-Mg7a
Myrmecia
MKLSCLSLALAIILLLAIVHSPNMEVKALAGPEADAIGFADAFGEADAFGEADAFGEADAFGEADAFGEADAKRSKSSSKTKPKKPKKPKKKIKIPDWVKSGGKMVGEAVAGAVADAAVSAVMDAAVGTTAEPEQ
May have antimicrobial properties, like most ant linear peptides.
P0DSK3
O31699
YKUV_BACSU
Thiol-disulfide oxidoreductase YkuV
Bacillus
MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLCKEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHALTDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
O31699
B4RJF9
ATPG_NEIG2
F-ATPase gamma subunit
Neisseria
MAVGKEILTKIRSVQNTQKITKAMQMVSTSKMRKTQERMRLARPYAEKVRMVMSHLAQTNTDHGIPLLESHREIRRVGFILITSDKGLCGGLNANVLKKFLAQVQEYRNQGIEEEIVCLGSKGLMACQSIGLNVVASAVNLGDTPKMEMLLGPLTELFQRYEKHEIDKIHLVYSGFVNTMRQEPRMEVLLPIGENVIGDSAPKPPFSWEYRYEPTALAVLEYLVRRYLESVVYQALSDNMASEQAARMVAMKAATDNAGNAIKELRLVYNKSRQAAITTELSEIVAGAAAV
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
B4RJF9
A8GNF9
RBFA_RICAH
Ribosome-binding factor A
spotted fever group
MKKLTKTNSHRQQKLASIINEALIEILRRGKMLDSRLFNCPLTITKVIVTADLKIANCYFLPFNTKLTINEVMNALNNSKKAIRNFITNKINVKFSPDIRFHYDHGFDNAIKVEELLKNIQVLGDKLNH
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
A8GNF9
A4SL70
KDSB_AERS4
CMP-2-keto-3-deoxyoctulosonic acid synthase
Aeromonas
MSFVVVIPARYASTRLPGKPLADIHGKPMVQHVVEKALQSGADRVIVATDDERVHSALASFAEQAGVEVCMTSQDHQSGTERLAEVCRHYGFSADTIVVNVQGDEPLIPPAIIRQVADNLAAASAPMATLSVPIQDAEEAFNPNAVKVVTDKEGYALYFSRACIPWDRDRFAASDRAAGSHEQIGDHYQRHIGIYAYRAGFIQRYVDWAPSVLEQVEALEQLRVLWYGEKIHVAQALQAPPVGVDTQADLDKVRALLAN
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
A4SL70
Q3KME9
RPIA_CHLTA
Phosphoriboisomerase A
Chlamydia
MSKQPENSFSSDKFFPIKQKLALEAVALVEPGMCVGLGSGSTAREFILALGDRVRTERLVITAVASSRISQLLAEAVGIPLLDHSLLQDVDLVVDGADEVDPCLRMIKGGGGALFREKILLQSGKRNVILVDERKLVPTLGKFSLPIEIAPFGCSSVQRILNKQGYFGEWRETSAGERFITDNGNYIYDVRTPDSYANPEEDMIRLLQIRGIIDVGFVIAKAEVWVGYADGSIVRKKKHNEY
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q3KME9
Q9Z0T6
PKDRE_MOUSE
Polycystic kidney disease and receptor for egg jelly-related protein
Mus
MWPGPALLLLGLGLGLGSQPPPTGPRGLPGVLRGAPGLGQGAESSVRGGDTGGLSPRAAPRHASPTPPRRCPSGAAARVLLKVNSSDPAAAKANVSCQTAPCIMQPVKINRKDQNAPLILSRDEEATLNITVRWYCPDALVIRKSWVYFSVASVNDTPDWNRPVLLPQVAVSKGFSLHIPKYALPYGVYVFNFTLSIFRWDLAWPTVTGSDIIYIWVRKRPLKAVLLGAPRVTVKFSDELILNGSMSYDPEADIPTWGLQFFWYCTTNPRYYSGNYVLVINQAVCHPEQDSLNWPWAVGSVLTIPPKTLRGNGVYYFRMVVQKQNRTAFSDKTVHVLQGLQPKAHISCIENCGPTLGVSDRFSLFLNCPSCGRQDLYSWSILSLTGHEVMFDWAGQAITRRNGPYLSIKAFAFRNFLENRVWVSLILKSWSGMTTTLRHPVVINHGPRVGKCKINPASGISMVTKFAVECSDFKDENLPLKYKIIVSELDSIGAISSVEENTLGSVVYSGAEPITPAFFLPVGTVTDEYNVRLYVQVYDSLGTFSQVTLQATVTAPTVRDSSKDVLQQLLNVTMKPTSLLSTLLQKQDWLQAGYLTYVVISVLNNIKGEQELQDDRARLLEHLVKQSLTFAMNTADEIGQSVMVITKLTQKASDLSQADLEATSFRLRQASQDLQEYQHRHKHLQQVEVVGTGILTSLSNLLKLINPYYTLQDPLFVVESLSDTILANKVPGSKTTALRTSYFNMYVEKVENWNVFKAFRNDSLCPNCLRATLNASTVPRLPAKAPISMMFCEFADDPFPWLTYPENISVDVVGFRMTGVADNNKVIEITPDIAEVYLVRKDLTPSSFNLTVGPGIKSDGFSKVTTGGISFEVDSRWTGELLIHIVTNVTVLFEALVYEGCQLTPTNLMATFLVPNDIPPIVKWSGLFDPTCSVKEARVVCLSSSLLRSIAQRRFSFKYNISMVLQASRFVLKPTNKLVRIALFMVHCLDMYGIQSDWQQSTCVLGEKTTWKTVHCVCRNGRRSRRQLTSVKLTYHHLHTHFVTAKVIVVPNPVDLRLAIISNLTQNPATFLAVLFIMILYAILAFWALHRDVIDLYFRDNVVILTDNDPFDTLCYLVTIFTGSRWGSGTRANVFIQLMGTEGTSDVHCLSHPYFKTLYRGSINTFLLTTKNDLGDIHSIRVWHDNSGEAPSWYLSRIKVENLFNKRIWLFVCRRWLSVDTTLDATFSVTNPDEPLKRTDFFMIDVRDKLRKNHMWISIFTEIVPKPFNRLQRLSCCLAMLLSSLVCNIMFFNLNQKEKIESRHMHIIRSMLIGIESVVITIPVQLLITFFFTYSQKNLKMNLDKVAPQKHPLMSEEGLSWKERLHKWHEYEMKALPRRAAVSTSAPEEKEAFETSQKHEKADTQMSNKNSSNNNQEASEGVPPKAFSSQPHTTESVQKKTQIILPRWCVYIAWFLVFATSGISSFFIVFYGVTYGYAKSIEWLFASFCSFCQSVFLVQPCNILLRSGTRSYKPKYCKNLSWSSKYHYSEIRLQGLTMTQEEMEQLHEDIAYVRSLSMYQPITEDKIQILRRENRIRRRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQFIRHRFSVDLATVMKLGDIYTWLHGVFLPLLHNDPNPTFLPDSSSKILGLPLVRQVRARPSNKTCLLAKKFVQSSVAGEIHCHPQYGIDPEDTQHYSSVWSKAGKQSTDKASHGFTYKPPGKRWVYHSYGVLNTYGSGGYVFYFFPGQQMFNSTVRLKELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTSSEIYLYAAILIFFCAYVVDEGYIIRQERASYIRSVYNLLNFSLKCMFALLIVLFFWKYFLATKMVQLYLADPEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLSSFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCNRLKSGFDFLTTRSRDKDQSNFFVDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV
May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Q9Z0T6
P82414
GTX3A_NEOGO
Ponericin-G1
Pachycondyla
GWKDWAKKAGGWLKKKGPGMAKAALKAAMQ
Shows a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. Has also antimicrobial activity against S.cerevisiae. Has insecticidal and non-hemolytic activity.
P82414
Q60181
RPO2C_METJA
DNA-directed RNA polymerase subunit B'
Methanocaldococcus
MKNLASREVNIYVNGKLVGTTDKPEELVNFIREKRRKGELPQYTTVAYNEESNDIHINTDAGRIVRPLIVVENGKPKLTKEHIEKLKKGEITFSDLVKEGVIEYLDAEEEENAYIALSEEELTEKHTHLEIDPLTILGIGAGVAPYPEHNSAPRITMAAAMGKQSLGIPMSNIKWRLDTRGHYLHYPQVPIVRTKHQEILGFDKRPAGQNFVVAIMSYEGYNMEDAIVFNKSAIDRGLGRSTFFRTYDACERRYPGGQMDRFEIPDKGVRGYRSEECYRYLEEDGIVAVESHVKGGDVIVGKTSPPRFLEEHEITIQVKPQRRDSSVVVRHGEEGYIDKVILTETKEGNRLVKVKVRDLRIPELGDKFASRHGQKGVMGLTVPQEDLPFTESGIVPDIIINPHAIPSRMTVGQLLEMLGGKVGALEGRRIDGTIFSGEKEWDLRKALEALGFKHHGKEVMYDGKTGKKFEVEIYIGIAYYQKLHHLVAGKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLMDESDPYDICICSKCGDFAILDYKRGLKYCPICGEIENLYSSKKIPFVRIPYAFKLLLDELKSMCILPRIKVRDKVELEDFEEFVEKLEKEKVKQKQ
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
Q60181
C3K424
HEM3_PSEFS
Pre-uroporphyrinogen synthase
Pseudomonas
MSSREIRIATRKSALALWQAEYVKARLEQAHPGLKVSLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENEADIAVHSMKDVPMDFPEGLGLFCICEREDPRDAFVSNTYASLDALPLGSIVGTSSLRRQAQLLTRRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFEDRITSAISVEDSLPAGGQGAVGIECRTADSDIHALLKPLDHHDTEVRVTAERALNKHLNGGCQVPIACYAVLEGENLWLRGLVGDPEGGNLLTAEVRGPQCDATALGIQVAQALLDKGAGAILQKVYGEAGPQ
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
C3K424
B7UFS6
MENH_ECO27
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Escherichia
MILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLYVDLPGHGGSATISVDGFDDVTGLLCKTLVSYNILNFWLVGYSLGGRVAMMAACQELAGLCGVVVEGGHPGLQNAEQRAERQRSDRQWAQRFRTEPLTAVFADWYQQPVFASLNDDQRRGLVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQILRF
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
B7UFS6
B5BIN8
ATPA_SALPK
F-ATPase subunit alpha
Salmonella
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPVDNDGFSAVEAIAPGVIDRQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIVVVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNAGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELAKIGSFEAALLAYVDRDHAPLMQEINQSGGYNDEIEGKLKGILDSFKATQSW
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
B5BIN8
Q9CN56
KT3K_PASMU
Probable ketoamine kinase PM0587
Pasteurella
MWKHVSQVLADQFGAYYSIKHKEKIHTGEMHEAWIIDDGIQPVFLKVNDKTFRSMFRAEADQLLLLAKTNTINVPNVYTVGCSHTHSFLLLEALPLDKTNPVDAMGKFGEQLAKLHLIKGADNYGLDFDTWLGPEYQPNGWKENWATFFSEQRIGWQLQICREKNLVFGDIEVLVKKVAELLAKHKPQPALLHGNLWIENCATVKQEIFTYDPACYWGDRECDLAFSELFEPFPRQFYESYDRTYPIDEGYPERKAIYQLYYLLNFSHRFNKHYVELTKKFIHDILSR
Ketoamine kinase that phosphorylates ketoamines on the third carbon of the sugar moiety to generate ketoamine 3-phosphate.
Q9CN56
A1JML4
ADD_YERE8
Adenosine aminohydrolase
Yersinia
MIDPRLPLTDIHRHLDGNIRAQTILDLGRQFNLSLPADELEALRPHVQITKTEPDLVSFLQKLDWGVAVLGSLEACRRVAYENVEDAANAGLHYAELRFSPFYMAMKHQLPVAGVVEAVIDGIQSGCRDFDIDIRLIGILSRTFGEQACLQELDGLLAHRDAITALDLAGDELGFPGGLFRSHFNRARDAGWRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDIKLMDYLAEHNIGIESCLTSNIQTSTVASLAAHPLATFLRHGVLASINTDDPAVQGIEIANEYHIAAPAAGLTPQEIRQAQENGLTMAFISEQEKQVLRDKIRN
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
A1JML4
A1RWT8
RS4_THEPD
30S ribosomal protein S4
Thermofilum
MGDPKKPRKKWQGPSHPWRKETLLEEMQLVGEYGLRNKRELWIAKSLLREIRAKARKLLALPAEERIKLEKPLVSRLYKMGLLPSEDASLDDVLSLTVRDVLERRLQTIVYRKGLATTIRHARQLITHGHIAVNSRRVRSPGYLVSRDEENFISYYEGSPLAKMAQGGAQNV
With S5 and S12 plays an important role in translational accuracy.
A1RWT8
Q7VIE2
GRPE_HELHP
HSP-70 cofactor
Helicobacter
MEEQEEKQYNQNIQDNEEGTQMREELQESTSAQQTLQEQEIDYQAKYLELKDQYVRAFADFENTKKRLERDKNQSLEYAYERIMNDLLPVLDTLEKALESAQSNPEAGAIAQGLQLTLEGFLKVLSKHGVEVIATDGEFDPNLHECLMQVPDANKNDGEILQTLQKGFVYKHRVLRPSMVSVVKN
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Q7VIE2
P07476
INVO_HUMAN
Involucrin
Homo
MSQQHTLPVTLSPALSQELLKTVPPPVNTHQEQMKQPTPLPPPCQKVPVELPVEVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEHQQQKQEVQWPPKHK
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
P07476
Q89YT0
END4_BACTN
Endonuclease IV
Bacteroides
MKYIGAHVSASGGVEFAPVNAHEIGANAFALFTKNQRQWVSKPLKEENIRLFKENCTKYNFQTDYILPHDSYLINLGHPEEEGLEKSRAAFLDEMQRCEQLGLKLLNFHPGSHLNKISIEDCLALIAESINLTLEKTKGVTAVIENTAGQGSNLGSEFWQLRYIIDRVNDKSRVGICLDTCHTYTAGYDIVNDYDKVFDEFEKEVGFEYLRGMHLNDSKKELGSHVDRHDNIGQGLIGSAFFERLMKDSRFDNMPLILETPDESKWAEEIAWLRSVE
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Q89YT0
A4QG75
PROA_CORGB
Glutamyl-gamma-semialdehyde dehydrogenase
Corynebacterium
MSSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEIIEANASDIEAGRANGMEESMIDRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGIQMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLRGSSTAVHSNTKLVEILQDVLERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTGNCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVTIHGRVAELEAFGATDVVEATETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIATQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIGISTQKLHARGPMALPELTSTKWILQGTGQIRP
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
A4QG75
Q3BU06
FLGI_XANC5
Basal body P-ring protein
Xanthomonas
MNLSSLPFRLLAAAVALCAIAAPASAERIKDLAQVGGVRGNALVGYGLVVGLDGSGDRTSQAPFTVQSLKNLLGELGVNVPANVNPQLKNVAAVAIHAELPPFAKPGQPIDITVSSIANAVSLRGGSLLMAPLKGADGQVYAMAQGNLVVGGFGAQGKDGSRVSVNVPSVGRIPNGATVERALPDVFAGTGEITLNLHQNDFTTVSRMVAAIDSSFGAGTARAVDGVTVAVRSPTDPGARIGLLSRLENVELSPGDAPAKVVVNARTGTVVIGQLVRVMPAAIAHGSLTVTISENTNVSQPGAFSGGRTAVTQQSTITATSEGSRMFKFEGGTTLDQIVRAVNEVGAAPGDLVAILEALKQAGALTAELEVI
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
Q3BU06
Q91X60
ACHA2_MOUSE
Neuronal acetylcholine receptor subunit alpha-2
Mus
MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETNMDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Q91X60
A5WDU0
METK_PSYWF
Methionine adenosyltransferase
Psychrobacter
MHDYQLFTSESVSEGHPDKMADQISDALLDAIMREDLHARVACETLVKTGAVVLAGEISTTANIDIERIVRDTVNSIGYNHSDLGFDGETCAVINMIGKQSPEIAQGVDRMNPEDQGAGDQGLMFGYASNETEVLMPAPIEFAHRLMERQSELRRSGELKWLRPDAKAQVTLKYTNGTPSAIDAVVLSTQHDPDISQADLQEAVMENIIKHVLPADLLHAGTRYHINPTGKFVIGGPVGDAGITGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEVQISYAIGVAEPTSISVNTFGTAKVSAEVIIELIRTHFDLRPYGITHMLNLLQPMYQQTATYGHFGRPGSETAFTWEKTDKAEILRADANI
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
A5WDU0
B8CM22
RNPH_SHEPW
tRNA nucleotidyltransferase
Shewanella
MRPSNRTPAQSRPVTITRQFTAHAEGSVLVEFGDTKVLCTASFEEGVPRFLKGQGQGWVTAEYGMLPRSTHSRMNREAARGKQSGRTQEIQRLIGRSLRAAVDMKLLGENTIVIDCDVIQADGGTRTAAITGACVALVDALNWARGKGILKTNPLKFLIAAVSVGIYKGEPICDLEYIEDSAAETDMNVVMTETGKMIEIQGTAEGEPFTHEELLSLLDLAKHGIREIVDIQKASLS
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
B8CM22
Q03SQ0
SECA_LEVBA
Protein translocase subunit SecA
Levilactobacillus
MPNILKRWVESDRRTLRRLSNLADKVGAYADDYAQLSDDDLKAKTPEFKQRYQDGETLDDLLPEAFAAIREGAKRVLGLYPFHVQIMGGIVLHEGNIAEMKTGEGKTLTATMPVYLNALAGKGVHVVTVNEYLSARDATEMGELYNWMGLTVGLNSAEKSPEEKREAYQADITYSTNGEIGFDYLRDNMVVYKEDMVQRPLNFAIVDEVDSILIDEARTPLIISGQSEGTSALYRRVDRFAKTLHEKDDFKIDLESKTVALTDTGIEKAEKYFNLKNLYDTDNTALTHHMDQALRANFIMLRDKDYVVQDGEVLIVDSFTGRVMDGRRYSDGLHQAIEAKEGVEIQEETKTMANITYQNLFRMYKKLSGMTGTAKTEAEEFREIYNMEVVSVPTNKPVVRVDEPDLLYPTLESKFNAVVKEIKDLHEKGQPMLIGTVAVETSEYLSQRLDEENIPHVVLNAKNHAKEADIIQNAGQRGAVTIATNMAGRGTDIKLGPGVVEIGGLAVIGTERHESRRIDNQLRGRSGRQGDPGMTQFYLSLEDDLMRRFGSDRVKSFLERMNVDGEDAVIRSRMITKQVESAQKRVEGNNYDSRKNVLQYDDVMRQQRDVMYGERNQVINQDKSLKWVLMPMIKRTVDRVVSLHTQGEQSDWDLDTLLDFGISAMVSPDKISLDDLKNKSADEIKAFFMELAEDVYAEKQKQLYDPAQMLEFEKVVLLRVVDSHWTDHIDAMDQLRQSIGLRGYGQLNPLVEYQQDGFRMFEEMISDIDYDATRLFMKSEIRQNITR
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Q03SQ0
Q482M9
RLMF_COLP3
rRNA adenine N-6-methyltransferase
Colwellia
MHKKNRHNQGYNFTALVKAHPGLLQFIIKNQYNNQDTIDFANPQAVKALNLSLLKSEYHVKFWDIPDGYLCPAIPGRVDYIHHLQDLLAATPKTLLPNKTPINVLDIGTGASCIYPILGQREYDWHFVASDVDPISIKVAKHIISSDKSLNRNINCRLQPNSNQIFNGIIAEDEFYHLTICNPPFHSSLAEASKGTARKIKNLNKGNHSSKNQDKTLNFGGQKAELWCPGGELAFIGKMIKESKAYQKQVLWFTCLVSKKDHLSKLKLSLKKSDAKQIKVIDMAQGQKISRFIAWSFYDVN
Specifically methylates the adenine in position 1618 of 23S rRNA.
Q482M9
Q0TLV0
CAIA_ECOL5
Crotonobetainyl-CoA dehydrogenase
Escherichia
MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDCLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
Q0TLV0
Q32BW5
GCSP_SHIDS
Glycine dehydrogenase (aminomethyl-transferring)
Shigella
MTQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPIGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLARAEAAEINLRSDILNAVGITLDETTTRENVMQLFSVLLGDNHGLDIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLADLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Q32BW5
O31164
RS17_SPICI
30S ribosomal protein S17
Spiroplasma
MERNSRKVLQGRVISDNLKKTITVLVETYKNHPLYKKRVKYSKKYLAHDEQNQAHIGDKVSIMETRPLSKTKHFRLIEVIEKAIG
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
O31164
P46380
AROQ_AMYME
Type II DHQase
Amycolatopsis methanolica group
MKVFVLNGPNLGRLGKREPA
Catalyzes a trans-dehydration via an enolate intermediate. Is involved in both the catabolism of quinate and the biosynthesis of aromatic amino acids.
P46380
O77418
ASP3_ANISI
ASPI-3
Anisakis simplex complex
MMFTPLIVLTLLVLATAEHQCGPNEQWSGCPKCELQSGESDKPCATICGEPKCYCSPDKYRRIPDGRCIRKIQCPQH
Defends the organism against the host's proteinases.
O77418
Q07933
ANFD_RHOCA
Nitrogenase component I
Rhodobacter
MPYHEFEVSKCIPERREHAVMKAAGEDLTSCLPKGYLNTIPGTISERGCAYCGAKHVIGTPMKDVIHISHGPNGCTYDTWQTKRYISDNDNFQLKYTFATDVKEKHVVFGAEGLLKKSMHEAFDAFPNIKRMTVYQTCTTALIGDDVDAIAKEVMEERGDVDVFVCNSPGFAGPSQSGGHHKINIAWLNQKVGTVEPDYLGEHVINYVGEYNIQGDQEVMIDYFNRMGIQVLSTFTGNGSYDSLRMMHRAHLNVLECARSAEYICDELRARYGIPRLDIDGFGFEPLANSLRKVALFFGIEDKAEAIIAEEYAKWKPQLDWYKERLKGKKVCLWPGGSKLWHWAHAIEEEMGLKVVSVYTKFGHQGDMEKGVSRCGEGALAIDDPNELESVEAIEMLKPDIIFTGKRPGEFVKKHGVPYLNAHAYHNGPYKGFEGWVRFARDIYNAIYSPMRQLAALDISAPDAAITSGFRTAKMNADLTVSDEVKFSEVLHEYTGKYDSIAEIRARNQPMPPSRKLRDAVQPAAE
This iron-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. Other nitrogenase complexes utilize a molybdenum-iron protein or a vanadium-iron protein.
Q07933
Q4FK66
PR38A_MOUSE
Pre-mRNA-splicing factor 38A
Mus
MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELKFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFVLMHVDEFIYELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPALRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE
Involved in pre-mRNA splicing as a component of the spliceosome.
Q4FK66
Q896Y2
MGLA_CLOTE
Galactose/methyl galactoside import ATP-binding protein MglA
Clostridium
MVENNIILEMNGISKNFPGVKALDGVDLKVKKGTVHALMGENGAGKSTLMKCLFGIYRSDDGEIVLGGKKVQFKNAKDALENGISMIHQELHPVPHRSVMENVWLGRFPVKKVFGLGIVDHKKMYEDTKDLLGKLKMNIDPNTLVSKLSVSQVQGLEIAKAVSYNSKIIVMDEPTSSLTENEVTHLFNIISDLKNQGVAIIYISHKMEEILKIADEVTIMRDGKYIGTWEAEGLTTDLIISKMVGRDLTNRFPPKENTPGEVIMKVENLTSANNKSFKDISFELRKGEILGIGGLVGAQRTELVESIFGLRKIETGKIYINGQEVKIKSPINSKKYGIALLTEERRSTGIFPVLTVGDNTIIAGLDKYIDLKFVVNQKRGMKDIKNSIEKLNIRTPSHATQIKNLSGGNQQKVIFSRWLLTEPDVLIMDEPTRGIDVGAKYEIYSIISDLSKMGKSIIMISSEMPELIGMSDRIMIMCDGRLSGIIEGEEATQEEIMKYATRFI
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
Q896Y2
P21866
KDPE_ECOLI
KDP operon transcriptional regulatory protein KdpE
Escherichia
MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.
P21866
A4FMQ2
LEU3_SACEN
Beta-IPM dehydrogenase
Saccharopolyspora
MRLAVIPGDGIGPEVVAEALKVLGEVVPDTEITRYDLGAARWHATGELLPESVLGELRQHDAILLGAVGDPSVPSGILERGLLLRLRFELDHHVNLRPARLYPGVKSPVSDPGEIDMVVVREGTEGPYAGNGGLLRKDTTHEIATEVSINTAFGVERVVRDAFARAASRPRKHLTLVHKTNVLTHAGSLWSRVVEEVSLQHPDVTVAYQHVDATTIHMVTDPSRFDVIVTDNLFGDIITDLAGAITGGIGLAASGNIDATRRNPSMFEPVHGSAPDIAGQGTADPTAAVLSVALLLDHVGQSEAARRVEAAVAFDLATRDHSAPGATFAIGDRLAALVSSREVAQQA
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
A4FMQ2
A8A0Z3
LEUE_ECOHS
Leucine efflux protein
Escherichia
MFAEYGVLNYWTYLVGAIFIVLVPGPNTLFVLKNSVSSGMKGGYLAACGVFIGDAVLMFLAWAGVATLIKTTPILFNIVRYLGAFYLLYLGSKILYATLKGKNSEAKSDEPQYGAIFKRALILSLTNPKAILFYVSFFVQFIDVNAPHTGISFFILAATLELVSFCYLSFLIISGAFVTQYIRTKKKLAKVGNSLIGLMFVGFAARLATLQS
Exporter of leucine.
A8A0Z3
Q2LQ87
RPOB_SYNAS
Transcriptase subunit beta
Syntrophus
MGEFRKNFGRIEEILEVPNLIDIQTRSYETFLQEDVAPENRKNFGLQGAFKSVFPISDFSGKCSLEFVSYKIGAVRYDVNECIQKGMTYAAPLKIVVRLVVFDTDRLSDQKNIRDIKEQEIYFGEIPLMTEKGTFIVNGTERVIVSQLHRSPGIFFDHDKGKTLTSGKLIYSARIIPIRGSWLDLEFDSKDLLYVRIDRRRKMPVTILLKAMGYSTEDLLNYFYDVEHIFCEGENFYAAVDESLVGHKLYDDIRDINTGEILFKKGRRINKVILKRIREQRVERIKMDVEELPGRILATDILDPETGEVLFHCNEALSAAGIDVVREKGIRELSVINLGEDLSNVSIRDTLLIDRMETPGDAIIEIYRRLRPSNPPTPDTAQKFFNSLFFENESYDLSTVGRAKMNYKLRLDVSTDVTVLRKEDIMAAVKYLIDLKNGVPECSVDDIDHLGNRRVRSVGELIENQYRIGLVRMERAIKEKMSLQDIETMMPHDLVNVKPVSAVVSEFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPVETPEGPNIGLIVSLSTYARVNEFGFIETPYRIVKEGRVLPEVKFLTAIEEENQVIAPADQPVNHDGSFKGDLISARKGGDFVNVVPSEVNMVDVSPNQLVSVAATLIPFLEHDDANRALMGSNMQRQAVPLMRPEIPLVGTGMERIVARDSGAVVVAKRSGIVESVDASRIVIKCESAEKTDRDTGVDIYTLIKYQRSNQDTCFNQKAIVNKGQRVRKGDIIADGPATDNGELALGHNVMVAFMSWGGYNYEDSILVSERIVKEDIYTSIHIEEFETMARDTKLGKEDITRDIPNVGEEALRNLDDSGIVRMGVSVKSGDILVGKITPKGETQLSSEEKLLRAIFGEKASDVRDTSLRVPPGVEGTVIDAKVFTRKGAEKDHRSQYIEDEAIAMLQKDREDEIRIITEAVKKEVGTLLQGKQSGAKIVDPKRKKIYLKKGDIITPEILSEIPLHLWKEITVADDEETERAVGQMMANLYDKIEVVEAYFNEKTEKLKASDELPPGVIKMVKVYIAIKRKLQAGDKMAGRHGNKGVLSRILPEEDMPYFKDGRPVDIVLNPLGVPSRMNVGQILETHLGWAAKGLGEKLNDMLDSYQKGNQLRDELKGIYQSREFEKFVDGATEEETYQFVRKLRRGIAVSSPVFDGATESDIRNMLKLANLPSTGQAILYDGRTGEPFDQEITVGMIYMLKLHHLVDNKIHARSIGPYSLVTQQPLGGKAQFGGQRLGEMEVWAMEAYGAAYSLQEFLTVKSDDVAGRTRIYEAIVKGENTSEPGLPESFNVLVKELQSLCLDVELIEEE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q2LQ87
Q7V335
GLYA_PROMP
Serine hydroxymethyltransferase
Prochlorococcus
MNILQNLKESDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIERAKQLFDADWANVQPHSGAQANAAVFLSLLKPGDTILGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNEIRDIALATKPKLIICGYSAYPRKIDFESFRRIADEVGAFLMADIAHIAGLVATKLHPNPIPYCDVVTTTTHKTLRGPRGGLILCKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALKPNFVNYSKQVINNAKVLSSTLIKRGIDIVSGGTDNHIVLLDLRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNDDAFVEVGEIIADRLLNPDDLLTEKKCKERVLTLCNRFPLYEVELEASIK
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Q7V335
Q5HX70
OBG_CAMJR
GTP-binding protein Obg
Campylobacter
MFIDSVKITLASGDGGKGAVSFRREKHVPLGGPDGGDGGNGGDIIFVCDNNTHTLVNFKGKRELRAQNGAGGMGRNKNGKKGENLELIVPEGTQVIDVQTNEILLDLTKEGQRELFLKGGKGGLGNTHFKHATNQRPDYAQPGIKGESRLVRLELKLIADVGLVGFPNVGKSTLISVVSNAKPEIANYEFTTLTPKLGLVDVDEYNSFVMADIPGIIEGASGGKGLGLAFLKHIERTSFLLFVLDPMRQMPLKEQFIVLRKELEKFSNELFGRKFGIMISKSDSVRLGEEFAEQIALNINELDNYLKEINNPQSFLIKVSSLEKTGLKELKFMLLEEIKTLRNNKKILTI
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q5HX70
B2JZ70
MUTH_YERPB
Methyl-directed mismatch repair protein
Yersinia
MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGVTWENSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEELMDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.
B2JZ70
Q72ID8
ARGR_THET2
Arginine repressor
Thermus
MGNKAERHRAIQEIVRREEIGTQKELVERLRQLGFEVTQATVSRDIAELGLARIALGKGRHRYVLPAADLPENAYEELKRQFGLFVRDVDRGGNLLVVKTAEGHASGIAYLLDRLRRDEIVGTLAGDDTILVVARTEEAAQALEDEFAGLLVEGRALRRALSGS
Regulates arginine biosynthesis genes.
Q72ID8
B5FA81
TRUB_ALIFM
tRNA-uridine isomerase
Aliivibrio
MARRRKGRPVNGVILIDKPTGITSNDTLQKVKRIYFAEKAGHTGALDPLATGMLPICLGEATKFSQFLLDSDKRYRVVAKLGERTNTSDSDGEVVQTREVKVDRGQLERCIAKFRGTTDQIPSMFSALKYQGRPLYEYAREGIEVPRESRKITVYSIELLRFEGHEVEMEVHCSKGTYIRTITDDLGEMLGCGAHVTYLRRTGVSNYPYENMVTIEDLEALLEQAHREERAPRELLDPLLMPMDSAVQDLPEVNMIPELADHVLHGQPVQVFGAPQDGIVRMTSGDERLFIGVGHIDDDGRVAPKRLVVFRDEEEK
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
B5FA81
A2SSW0
RS13_METLZ
30S ribosomal protein S13
Methanocorpusculum
MVEESELKYFVRIINTDLDGTQPVQLALTGIKGIGLHAALIIARRAGVDTRATMGLLGDEDVAAIEEQVKAYPASVPKWMVNRPVDVYSGEPKHLYGSDLSLAKEDDINLMKKMRCYRGIRHENGLKVRGQRTKATGRFGKIVGVSKRRN
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
A2SSW0
Q48KZ1
TIG_PSE14
PPIase
Pseudomonas
MQVSVENTSALERRMTIGVPAERIETEVNKRLQQTARKAKIPGFRPGKVPMSVIRQRYEDGARQEALGDLIQATFYEAVVEQKLNPAGAPAVEPKSFEKGKDLEYVATFEVFPEFTVAGFDTIAVERLSADVVDSDLDNMLEVLRKQNVRFEVADRAAQNEDQLNIDFVGKVDGEVFAGGSATATQLVLGSGRMIPGFEDGLVGAKAGEERVLNVTFPEDYQNLELAGKAAEFTVTVNTVSEPKLPELNEEFFKQFGIKETGIEGFRTEVRKNMERELRQAIKSKVKNQVMDGLLAANPIEVPKALLENEVNRLRVQAVQQFGGNIKPDQLPAELFEEQAKRRVELGLIVAEVVKQFDLKPDDARVREMIQEMASAYQEPEQVVAWYYKNEQQMNEVRSVVLEEQVVDTVLQKASVTDKSVSYEEAVKPVEAPKAD
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q48KZ1
P69589
RBL_LUPPI
Ribulose bisphosphate carboxylase large chain
Lupinus
SVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPNAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLASEGNQIIREASKWSPELAAACEVWKE
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P69589
P47859
PFKAP_RABIT
Phosphohexokinase
Oryctolagus
MDNKVSASPRGSYRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIVEANWESVSSILQVGGTIIGSARSKAFRTREGRLKAACNLIHRGITNLCVIGGSGSLTGANIFRMEWSGLLEELAQDGKIDNEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSACHRIIEVIDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRAQKKRLNIIIVAEGAIDTLNRPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLEATPETPACVVSLSGNHAVRLPLVECVQMTQEVQKAMDERRFKDAVQLRGRSFENNLNTYKRLAIKLPDDKIQKSNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAVYDGFDGFAKGQIKEIRWGDVGGWTGQGGSILGTKRILPGKYLEEIATQIRTHNINAILIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGRGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMQWITTKLKESPGKGKRFVSDDSICVLGISKRNVLFQPVAELKNETDFEHRIPKEQWWLKLRPLMKILAKYKTSYDVSDSGQLVPVRHRGGPEEPAAI
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
P47859
Q5LYH7
Y1598_STRT1
Nucleoid-associated protein str1598
Streptococcus
MMNMQNMMKQAQKLQKQMEKSQAELAATTFTGKSAQDLVVAELTGDKKVVNITFADAVVDPDDVETLQDMTVQALNDALGQIDEATKKSMGAFAGKLPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q5LYH7
B1KIW2
FETP_SHEWM
Probable Fe(2+)-trafficking protein
Shewanella
MARTVNCVYLKKEAEGLGFQLYPGPLGKRIFDNVSKEAWGLWQAKQTMLINEKKLNMMNVEDRGFLETQMVNFLFEGKDVEIEGYVPQKDDD
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
B1KIW2
A4Y493
G6PI_SHEPC
null
Shewanella
MTLLTQSSTWQALSAHTQNLPHMRELFATDAARFKNMSLSACGLFLDYSKNRATAETLELLFSLAKDSQLEAKIKAMFAGEIINTTEKRAVLHTALRSKASQSIIAEGQDIVLEVQQTLSKMQEFVETVTSGQWKGYTGKAITDIVSIGIGGSFLGPKVVSQALRPYWNQGLNCHFVANVDGTSISEKLKLLDSETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGLQSDVAKHFVAVTSNVTKATEFGIDANNIFPMWDWVGGRYSLWSAIGLPIALLVGMDNFRALLNGAHQMDEHFASAPLAENMPVIMGLLSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLDGTDVDYSTGPVIWGGEGTNGQHAYHQLIHQGTALIPADFIMPLQSHNPIGVHHDQLASNCFGQTQALMQGRTFEEALAELANSSLTDEEKQLIAKHKVMPGNKPSNTLLMNKLTPETLGALIALYEHRTFVQGAIWDINSFDQWGVELGKNLGNDVLARISAEQDSSALDASSNGLINLYRQGAI
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
A4Y493
A8Z5Q4
MNMG_SULMW
Glucose-inhibited division protein A
Candidatus Sulcia
MFVKQYDVIVVGGGHSGSEAALAASNLGSNTLLITTNLYNIGQMSCNPAMGGIAKGQMIKEIDALGGYSGIITDKSMIQFRMLNKSKGPAMWSPRAQCDRLKFSKEWRLTLEKKKNLSFFQSTVVDLIIKNYKVIGVKTILGIYIKSKSVILTNGTFLNGIIHIGDKKNSGGRISENSVKGLTEKLKKIGFFSGRMKTGTSPRLDGRSLDFSKMIEQLGDFPIEPFSYLSNLNILKQKKCYITHTNLETHNLLSKEFNRSPIFNGKIKCVGPRYCPSIEEKVYRFSNKENHQIFVEPEGVNTIEVYINGFSTSMPEEVQYKALLTIPGFEHAKMVRPGYAIEYDYFPPTQLKNNLETKLIENLFFAGQINGTTGYEEAAAQGLIAGINANLKINEKDPFILKRNEAYIGVLIDDLIYKGTEEPYRMFTSRAEYRILLRQDNADERLTHMGINLGLVSYDRIKKLKNKNKNKKQCFLFFKINKANNLILKENIKICDLLSRPEISIYDIIKLSLIKNFIKKNNIDKKILEQISLYIKYKGYLLKEEENVKKMYRLETIRIPNDFDYNQVKSISIEAREKLLNYKPNSIGEASRISGVSPSDIRILILFLIKK
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
A8Z5Q4
A4TBJ9
LIPB_MYCGI
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Mycolicibacterium
MSSVEGMAQSIRSGTEPVRVQWLGRIDYQAAWDLQRELAEERIAGGPDSLLLLEHPEVYTAGRRTLAHERPVDGTPVIDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVNFVRRLEESLISVCASFGVQTGRVEGRSGVWVAGDGGRPDRKIAAIGIRVARATTLHGFAINCDCDLGAFGSIVPCGIADAGVTSLTAELGRTVGVAEVIDRVSEAVLDALDGRIALGVASSPGVDSAQ
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
A4TBJ9
Q138Z3
BIOB_RHOPS
Biotin synthase
Rhodopseudomonas
MNSIDLPSLAQALADSTPTIRHNWTREEAAAIYHAPFADLIFRAQTIHRQSFDANAVQCNQLLNVKTGGCAEDCGYCSQSSHHDTALPASKLMDPAKVIEGAKAARDAGATRYCMGAAWRSPKDRDMAPVIEMVKGVKALGMEACMTLGMLTDDQAKQLADAGLDYYNHNIDTSEEFYSSVVKTRSFGDRLETLEKVQDAGIKVCCGGILGLGEKPTDRVEMLRTLANLPQHPESVPINMLIPIEGTPIAATATPVDPFEFVRTIALARIMMPKSDVRLAAGRTAMSDEMQALCFLAGANSIFIGDTLLTTPNPGDSKDRALFARLGITPRDDLGVHAHGNA
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Q138Z3
O33807
BLC4_SALTM
Cefotaximase 4
Salmonella
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVAQINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIRASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGMPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF
Has cefotaxime-hydrolyzing activity.
O33807
B2VK57
RL16_ERWT9
50S ribosomal protein L16
Erwinia
MLQPKRTKFRKVHKGRNRGLAQGTDVSFGTFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLEVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
B2VK57
C6DHS8
NUDC_PECCP
NADH pyrophosphatase
Pectobacterium
MEQTLKGDETGWWVVSDAVQIWLPQGELPCGTATKWSLQGKTARQIGEWQEQPVWLVCQGRDTDMASVRQLLDQDVGLFQLAGRGVQLAEFYRSHRFCGYCGHEMVRSKTELACLCHHCKERYYPQIAPCIIVAIRRGEEILLAQHNRHRGNMYTVLAGFVEVGETLEQTVVREVMEESQVQIKNLRYVSSQPWPFPHSLMMAFMAEYAGGEIKHDPKELRDAGWFRYDQLPQLPPPGTVARRLIEDTVVLCRAYHENEG
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
C6DHS8
B5FBS8
FRDD_ALIFM
Quinol-fumarate reductase subunit D
Aliivibrio
MVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILVPLGVIGPESMNYLRVAGFVTSIIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKIACYAAAALATVLSVVFIFMI
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
B5FBS8
A6LUQ4
BIOB_CLOB8
Biotin synthase
Clostridium
MEKLAEEIINGRRLTRSDDLEFLLTCDLKKICDGANKIRKTLCGESVDLCTIINGRSGKCSENCKFCAQSNHHKTEIKKYDFLDPNVILKDCKKNEANGVHRYSIVTAGRALVGSDFDKAVQAYKMMNKECSINLCASHGFLSEEQFVLLKEAGVTMYHANIETSKRNFHNICTTHSYDDKIKEIKLAQNAGLKVCSGGIIGMGETWYDRIDMAISLSELGVISIPINVLMPIKGTPLENLKRISNYDILRTIAIFRYINPTAYIRMAAGRTYFEDGGIEIFQSGSNATITGDMLTTVGNNTCQDKIMLQTLGFSI
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A6LUQ4
B7IHV5
RS17_THEAB
30S ribosomal protein S17
Thermosipho
MPKKKLIGEVVSDKMDKTVVVAVSTLVKHPRVGKYIKRTKKYYAHDENNECRDGDIVEIIESRPLSKLKRWRVLRIVERSVFADETLDEELEGGSSDDN
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
B7IHV5
Q32DZ9
MACB_SHIDS
Macrolide export ATP-binding/permease protein MacB
Shigella
MTPLLELKDIRRSYPAGDEQVEVLKGITLDIYAGEMVAIVGASGSGKSTLMNILGCLDKATSGTYRVAGQDVATLDADALAQLHREHFGFIFQRYHLLSHLTAEQNVEVPAVYAGLERKQRLLRAQELLQRLGLEDRTEYYPAQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEEVMAILHQLRDRGHTVIIVTHDPQVAAQAERVIEIRDGEIVRNPPAIDKVNVAGGTEPVVNTVSGWRQFVSGFNEALTMAWRALAANKMRTLLTMLGIIIGIASVVSIVVVGDAAKQMVLADIRSIGTNTIDVYPGKDFGDDDPQYQQALKYDDLIAIQKQPWVASATPAVSQNLRLRYNNVDVAASANGVSGDYFNVYGMTFSEGNTFNQEQLNGRAQVVVLDSNIRRQLFPHKADVVGEVILVGNMPARVIGVAEEKQSMLGSSKVLRVWLPYSTMSGRVMGQSWLNSITVRVKEGFDSAEAEQQLTRLLSLRHGKKDFFTWNMDGVLKTVEKTTRTLQLFLTLVAVISLVVGGIGVMNIMLVSVTERTSANDIPMDVGAGASYVLYHLFFRYPCKVLPAVGGALGITLSLLIAFTLQLFLPGWEIGFSPLALLLAFLCSTVTGILFGWLPARNAARLDPVDVLARE
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Q32DZ9
A8MLJ8
DNLJ_ALKOO
Polydeoxyribonucleotide synthase [NAD(+)]
Alkaliphilus
MGSMERLRQLVDILNEYSYQYYVLDEPVVSDKEYDQLYDELVLLEKELNTVLEDSPTIRVGGDVLKNFKAHNHLAPLWSLDKCKTPEELISWDLRVRRLLEGSGVPIEYVMEYKFDGLTLNLTYNNGQLVQAATRGNGTTGEGILEQVKTIKTIPLTIPHKGRIEVQGEGLMGLSVLAAYNKTALEPLKNPRNAAAGALRNLDPKVTAKRKLSAFCYNVGFYEGIDFNTHMEILAFLKANKFPVSNYTKKFHTIHQVIEEIETIGEQVKSLDFLTDGLVIKVNHMEARRLLGYTQKFPRWAMAFKFEAEEMTTELKDVIWQVGRTGKLTPAAVLEPIDIGGVTVSRATLNNWEDIQRKKVKIGCRVWIRRSNDVIPEIMGSIEETLEGAMDIEKPQHCPACHSEVVERGAHIFCPNSLSCKPQLVSRIVHYASRDAMDIVGFSEKTAEQLFEELNLRDLADLYEIKYEDLIKLPRFGDKKARNLLEAIENSKNCKLDSFVYALGIPNVGRKTATDLAKHYKSFQAIQEAEFQELITLPDVGDIVAQSIIDFFEDEEIKKSVNRLINEGIRPLFKEVEQQENIFLGKTVVVTGTLEKYGRKEIKELLEKLGAKVTGSVSKNTDFLLAGEAAGSKLEKAMEIIASGVETSLRIISEAEFEAML
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
A8MLJ8
Q28WQ1
KIF1A_DROPS
Kinesin-like protein unc-104
Sophophora
MSSVKVAVRVRPFNSREIGRESKCIIEMTGATTAITNPKVPPNTSEAVKRFNFDYSYWSHDPRDSDFSTQTMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICQDLFTRIHDTETDELKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDTMTDLTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKHNKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELNKSTTGIKSPSKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRLQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKDGLTRLGTHEANVPQDIQLSGSHILKEHCTFENRNSTVTLLPHKDAIIFVNGRQLVEPEVLKTGSRVILGKNHVFRFTNPEQARELREKITENEAENEVEKADAPQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKMQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYNNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASSVAPLQQEDEFGAPPVSKTLVAVEVTDTKNGATHYWSLEKLRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGHDSKLEELEDVDSGRGIDSNSASDCPENAEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCPPSSTVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTPEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEVLDVPGDDRSFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAIVTKDLSMVIYGRDARTGPRSLKHLFSGQYRNPEANRLSGVYELSLRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEKDVCNLAARAATSPVHMVIPQSPQTPVKDPQQIMPEREYNQREQDLMLKCLKLVQAGRYAKNEANDTQTQSDVSPSDEGCADMTVSCISSNSMEDNKFVIRRRLCSPDRADAPNGWEAPAPATQPALPLRLYVPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVTVRRPYVFIYRSEKDPVERAVLNLATAQVECSEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARRTLEPASQTASQIQASSAANANSANK
Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.
Q28WQ1
Q5X112
GLMU_LEGPA
Glucosamine-1-phosphate N-acetyltransferase
Legionella
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPDAIHVIYGHGGEQIKSSLPNLPVHWVHQAEQLGTGHAVLQAMPHIPDDAYVLVLSADVPLIQVGTLQSLIECSQRQNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKDANEQVKNIKEIYSGVCCTLANNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLERTWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCSLTNVTLGDGCEVYANSVLEGCHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDEGTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTIIEDGVFIGSDTQLVAPVTVGANATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Q5X112
C5CDH9
RL21_KOSOT
50S ribosomal protein L21
Kosmotoga
MYAIIEASGKQYKVEEGITLFTEKLKDFAEGDQVVFDRVLLLKDDSGVKVGKPYLENVKIVGKVVRHGRGKKIRVVKFRPRKNYHRVKGHKQWFSEVLIEKIEY
This protein binds to 23S rRNA in the presence of protein L20.
C5CDH9
P33749
MSN4_YEAST
Multicopy suppressor of SNF1 protein 4
Saccharomyces
MLVFGPNSSFVRHANKKQEDSSIMNEPNGLMDPVLSTTNVSATSSNDNSANNSISSPEYTFGQFSMDSPHRTDATNTPILTATTNTTANNSLMNLKDTASLATNWKWKNSNNAQFVNDGEKQSSNANGKKNGGDKIYSSVATPQALNDELKNLEQLEKVFSPMNPINDSHFNENIELSPHQHATSPKTNLLEAEPSIYSNLFLDARLPNNANSTTGLNDNDYNLDDTNNDNTNSMQSILEDFVSSEEALKFMPDAGRDARRYSEVVTSSFPSMTDSRNSISHSIEFWNLNHKNSSNSKPTQQIIPEGTATTERRGSTISPTTTINNSNPNFKLLDHDVSQALSGYSMDFSKDSGITKPKSISSSLNRISHSSSTTRQQRASLPLIHDIESFANDSVMANPLSDSASFLSEENEDDAFGALNYNSLDATTMSAFDNNVDPFNILKSSPAQDQQFIKPSMMLSDNASAAAKLATSGVDNITPTPAFQRRSYDISMNSSFKILPTSQAHHAAQHHQQQPTKQATVSPNTRRRKSSSVTLSPTISHNNNNGKVPVQPRKRKSITTIDPNNYDKNKPFKCKDCEKAFRRSEHLKRHIRSVHSTERPFACMFCEKKFSRSDNLSQHLKTHKKHGDF
Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes.
P33749
Q9XI47
SHH1_ARATH
DNA-binding transcription factor 1
Arabidopsis
MAASDDSSHYFTEFTLSEIVDMENLYKELGDQSLHKDFCQTVASTFSCSVNRNGKSSITWKQVQIWFQEKLKHQSQPKSKTLPSPPLQIHDLSNPSSYASNASNATFVGNSTFVQTRKGKASDLADLAFEAKSARDYAWYDVSSFLTYRVLRTGELEVRVRFSGFDNRHDEWVNVKTSVRERSIPVEPSECGRVNVGDLLLCFQEREDQALYCDGHVLNIKRGIHDHARCNCVFLVRYELDNTEESLGLERICRRPEE
Involved in RNA-directed DNA methylation (RdDM). Required for the silencing of some endogenous RdDM targets and accumulation of 24-nt siRNAs, but not for the production of Pol V-dependent transcripts. Functions in transcriptional silencing through both DNA methylation-dependent and -independent pathways. Required for both maintenance and de-novo DNA methylation. Plays a role in the recruitment of Pol IV to genomic regions associated with K9 methylated histone H3 that are targets for RdDM.
Q9XI47
P24586
KPST5_ECOLX
Polysialic acid transport ATP-binding protein KpsT
Escherichia
MIKIENLTKSYRTPTGRHYVFKDLNIEIPSGKSVAFIGRNGAGKSTLLRMIGGIDRPDSGKIITNKTISWPVGLAGGFQGSLTGRENVKFVARLYAKQEELKEKIEFVEEFAELGKYFDMPIKTYSSGMRSRLGFGLSMAFKFDYYIVDEVTAVGDARFKEKCAQLFKERHKESSFLMVSHSLNSLKEFCDVAIVFKNSYIIGYYENVQSGIDEYKMYQDLDIE
Putative ATP-binding protein, and an energy coupling component for the transport of polysialic acid across the cytoplasmic membrane.
P24586
Q5L6H0
TPIS_CHLAB
Triose-phosphate isomerase
Chlamydia
MERKRYIFGNWKMHKTAKEAKDYLSVFCPLLEEVAPVSCVGITPAFTALHACCESIKFFHSPLWLGAQNVHQDTSGAFTGEISLPMLKEFDVNFVLLGHSECRHIFHEEDTTIALKVGAAAREGIIPVLCIGETLEVREKGATEAMLSNQLMLGLAQLPETASVIIAYEPVWAIGTGKVASAVDVQEAHAFCREVLANIFSKEKAEEISILYGGSVKADNAEGFARCPDVDGLLVGGASLDPKVFADVVANFHR
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q5L6H0
B9K7B8
MUTL_THENN
DNA mismatch repair protein MutL
Thermotoga
MRIRRLPESLIRKIAAGEVIHNPSFVVKELVENSLDAQANRVVVEVENGGKNLVRVSDNGTGMTKEEVLVAIEPHTTSKIESEEDLRRIRTYGFRGEALASIVQVSRTRIVTKTKEDALATQVLITGGKVEEISETHRDTGTTVEVKDLFFNLPVRRKSLKSSSIELRMCREMFERFALVKNNVDFTFISDGKIIHSFPATSDLFERALLILEDLRKGYITFEEELSDLKIKGIVSAREITRPNRTGEYFYVNERFVISEELHEVLMKVYDLPKRRYPIAVLFIETDPEKLDINIHPSKIVVRFLEEEKVKEALEEVLTKNLARKWYRSVTYEEISSRALSVAEPSSYRWFLVKKKYAVVETEDALFFIDLHALHERVIYEEILAKRVWRSKNLKRRVITSLPDEKLEKLEKLGFSFQFEGESLVVRKVPEFLTEDAVEEFFKEIIHGSTEMLREKIALAACKLATRSGEFDEKTASKLVDLYFQKKYERCPHGRPVSFRISYEDLDRFFER
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
B9K7B8
C1L082
SYS_LISMC
Seryl-tRNA(Ser/Sec) synthetase
Listeria
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIAKLKREKQDADAKIEEMRVVGDRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDDNVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTGSRFVFYKKLGARLERALINFMMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYHREDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALEKLTGNAEEVLRRLELPYRVLSMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENYQDADGSVRIPKVLQGYMGGIEKIELPK
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
C1L082
P19959
3S12_AIPLA
Short neurotoxin B
Aipysurus
MKTLLLTLVVVTIVCLDLGYTLTCCNQQSSQPKTTTDCADNSCYKMTWRDHRGTRIERGCGCPQVKPGIKLECCKTNECNN
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
P19959
B8D0S4
CYSC_HALOH
Adenosine-5'-phosphosulfate kinase
Halothermothrix
MRNQKGVTVWFTGLSGAGKTTVAREVERQLKEKGYYVQRLDGDIVRQHLTRDLGFTKEDRDENIRRNSFVAKLLTQNDIITLCSFISPYRKARQTAREIIGEFIEVYVNAPLEVCEDRDVKGLYAKARAGEIDNFTGISDPYEPPQNPDLELRTDKETVEESASKVIEYLEEKGYINLPEDVLAG
Catalyzes the synthesis of activated sulfate.
B8D0S4
P36499
LAN4_LACLL
Lactococcin-DR
Lactococcus
MKEQNSFNLLQEVTESELDLILGAKGGSGVIHTISHECNMNSWQFVFTCCS
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacticin 481 is a broad spectrum bacteriocin exhibiting activity against a wide range of lactic acid bacteria and C.tyrobutyricum.
P36499
Q2KD47
DAPE_RHIEC
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Rhizobium
MTATDPVANLQTLIRCPSVTPAEGGALTALDAMLTPLGFTVDRVTAREEGTAAIENLYARLGRDGPHLMFAGHTDVVPVGDEAAWTHPPFAAEISNGELFGRGAVDMKGGIACFVAAVARHIEKSGPPAGSISFLVTGDEEGPAINGTIKLLQWAAERGERWDACLVGEPTNPDRLGDMIKIGRRGSLSGKITVHGVQGHAAYPHLADNPVRGLLQLTQALMDPPFDGGTDDFQPSNLEVTTVDVGNPATNVIPAKASASFNIRFNDSWTVETLRAEILRRLEAAAGNGQLRPGRPPAKYDIVWADRPSHVFLTRNNALIASLSSAIESVAGRSPALSTTGGTSDARFIKDYCPVVEFGLVGQTMHMVDERVAVADLETLTAIYQTFIDRWFAHAGS
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Q2KD47
Q8MBQ3
ATPB_IPOQU
F-ATPase subunit beta
Ipomoea
MRINPTTSGSEVSAVEKKNLGRIVKIIGPVLDVAFPPGKMPNIYNALVVQGRDNEQTNVTCEVQQLLGNNRVRAVAMSDTDGLMRGMEVIDTGAPISVPVGGSTLGRIFNVLGQPVDNLGPVDTNTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYLEMKESGVINEENIPESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLKT
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q8MBQ3
Q4X1D2
EIF3L_ASPFU
Eukaryotic translation initiation factor 3 subunit L
Aspergillus subgen. Fumigati
MSYEERVNAHPNLGDESDVEEEALVNDYREQVNFDDGMSELDRTTSLGTGSQTQDLQAQLAAAATPLEYQATLETKFASYDNYCSLFHYILNSEGPVELEVPSYYWAWDVIDEFIYQFESFCRYRNRVARSGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQKSQINEQLAAIKRGEDPLAFAGEYGSRPLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYGDAIRMFSHILVYVSRTKNFQKGGNSYDAIAKKNDQMYALIAICVALHPTRLDDTIHSALREKYGEQLLRLQHGGPDALPLFEELFRSACPKFISPTPPDFDNPALNIDPVDHHTAIFMDEVKNTLYNPTIRSYLKLYTTMDLKKLAGFLEVQPEVLRSWLLVNKQRSRQVRWVEGGLLEGEVVSANDLDYALENDLIHVSETKAGRRLVDWYLRNLARVY
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Q4X1D2
Q5WBF8
PXPA_ALKCK
5-oxoprolinase (ATP-hydrolyzing) subunit A
Alkalihalobacillus
MNAIDLNSDVGESYGAYTIGNDEKIMPYISSANIACGFHAGDAHVMRETVARALEHSVAIGAHPGLPDIGGFGRRNIDISPQEGYELVVYQIGALWAIAKAQGGKLHHVKPHGALYNMAAADQALAEAIANAVYDVDPNLVFYGLAGSALIAAGKKAGLKTASEVFADRTYQADGSLTSRRAPNALITDAKEASAQVLRMIQEGKVRTQQGTDVKIDAQTVCIHGDGAQAVAFAEQLKGELERHGITVKAGNC
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Q5WBF8
A4IM26
LSPA_GEOTN
Signal peptidase II
Geobacillus
MGGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQGQFWLFYLVTVIVVAGIIIYIRRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIHTYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
A4IM26
A0QF47
MURE_MYCA1
UDP-N-acetylmuramyl-tripeptide synthetase
Mycobacterium avium complex (MAC)
MVSVPTGLRPSAVPGVRLPALADQVGAVMAGPDRRAAVPDVTVTGVTLRAQDVLPGDLFAALPGATTHGARHAAEAIERGAVAVLTDAAGVAQLTGGRTTPTLLHPRPRSVLGELAAAVYAHPSERLTVIGITGTSGKTTTTYLVESGLRAAGRTAGLIGTVGIRIDGADIPSALTTPEAPALQALLAAMAEQRVDTVVMEVSSHALALGRVDGTRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPNSPLRAHRAVVCIDDEAGREMAARAGDAVTVSAEGQPAHWRAVEVAPLGTGGQQFTVIDPAGVQHRAGIRLPGHYNVANCLVALALLDAVGVSPEQAAPGLLQTRVPGRMEEIDAGQDFLALVDYAHKPGALRAVLSSLKRPDRRLAVVFGAGGERDPGKRAPMGATAAELADLVVVTDDNPRGEDPAAIRREILAGATESGCAAEVIEIGDRRAAIRHAVAWAGPGDVVLVAGKGHETGQRTGEHTRPFDDRVELAEALREAVGPRKAQG
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
A0QF47
C5BCN2
END4_EDWI9
Endonuclease IV
Edwardsiella
MKYIGAHVSAAGGLDQAPARAHALEATAFALFTKNQRQWKAAPLTDDAIDAFRAACTRYGYQSQQILPHDSYLINLGHPVTEALEKSRGAFIDEMQRCADLGLTLLNFHPGSHLLQIDERDCLSRIAESINLALSQTQGVCAVIENTAGQGSNLGFRFEQLAAIIEQVEDKSRVGVCIDTCHAFAAGYDLRDEAACGETFAQFSRTVGFSYLRGMHLNDAKSAFNSRVDRHQSLGEGNIGDAAFRWIMRDPRFDGIPLILETTDPGRWQDEIAWLKAQQTAE
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
C5BCN2
Q88MG4
ACCA_PSEPK
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Pseudomonas
MNPNFLDFEQPIADLQAKIEGLRLVGNDNSLNISDEIARLQDKSNTLTESIFGNLTSWQIARLARHPRRPYTLDYLEHIFTEFEELHGDRHFSDDAAIVGGTARLDGKPVMVIGHQKGREVREKVRRNFGMPRPEGYRKACRLMEMAERFKMPILTFIDTPGAYPGIDAEERNQSEAIAWNLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYSVISPEGCASILWKTADKAADAAEAMGITAERLKSLNIVDKVIQEPLGGAHRDPAKMSESIRADLVQQLDMLGKFDNDALLARRYERLMSYGL
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Q88MG4
A9KBT1
YIDC_COXBN
Membrane protein YidC
Coxiella
MDIKRIILYVIVALLAIALFNAWQRDYPPTPKPTPTVEQPTANGDHPTAYTPPAFTPGAAEKTKKAGTIALTSKVPEARLITVRTDVLDVEIDTQGGNIVSAKLPKYPVSLEEKQTPVQILSGEPNELYVAQSGLTNGNGQPTTVQFESAKKQYVLENGQNQLIVQLTGRAPDGLLVTKTYTFHRDDYAIHLAYQVKNNTSKPWQGSLYTQITRRQPPTEHHHFYVRSYNGASMGSPQTPYEKLSYESLDKQNIDRTSQSGWIAMQQHYFLSAWVPGNPELTYHYYSHVIPASGEPNVYVVGFVSPQMNVAAGSEAATHATLYVGPEIAKRLKGLAPGLERTIDYGWLWPISMLLFWILSSVHAVVKNWGWSIIITTILIKIVFYWFSAKSFRSMARMREMQPRIQALKERHGDDRQALSRATMELYRKEKINPLGGCLPMLIQVPVFIAFYYVIIESVQLRQAPFIFWIHDLSVKDPYYILPIIMGLSMLAQQWLSPTSPDPTQQKMMWILPVIFTVFFINFPAGLVLYWITNNVVQTLQQWYVNKTYESHKAKLKARRARKRKR
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
A9KBT1