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taxon
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sequence
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2.75k
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5.51k
AlphaFoldDB
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10
P57880
TPX_PASMU
Thioredoxin-dependent peroxiredoxin
Pasteurella
MSKITLAGTEIEVSGVFPQVGDVVTDFTTVSAKLEDTTLANFAGKRKILNIFPSIDTGICATSVRKFNEQAAKLANTAVLCLSTDLPFAQARFCGAEGLENVFTVSTFRNKDVHKQLGVDIVEGPLAGLTARAVIVLDENNRVLHSELVPEIKQEPNYDAALAVL
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
P57880
A4XUW4
UVRC_PSEMY
Excinuclease ABC subunit C
Pseudomonas
MSVSFDSSAFLATCSGRPGVYRMFDADARLLYVGKAKNLKKRLSSYFRKTGQAPKTAALVARIAQVETTITANETEALLLEQTLIKEWRPPYNILLRDDKSYPYVFLSDGEFPRLGIHRGAKKAKGRYFGPYPSALAIRESLSLLQKTFLVRQCEDSYYRNRTRPCLQYQIKRCKGPCVGLVSPEEYAEDVRHSVMFLEGRSNALSEELSASMEKASMALEFERAAELRDQISMLRRVQDQQSMEGGSGDVDVVAVMLNPGGACVHLISVRGGRVLGSKNFFPQVAIEEEGGEVLMAFLAQYYLGNAERDLPSELIVNVQHEDFSTLIEAVESLRGRSLSISLRVRGTRARWQQLAVTNAEQALAARLANRQHLAERFEALATVLEMDEPPQRMECFDISHSSGEATVASCVVFGPEGPLKSDYRRFNIEGVTPGDDYAAMHQALTRRFSKIKDGEGKLPDVLLVDGGKGQLAMAREVLQELAVPDLILLGVAKGTTRKPGLEVLYLNDAEHEFTLPGNSPALHLIQQIRDESHRFAITGHRARRGKARRTSTLEEVAGIGPKRRRELLNHFGGLQELSRASAEEIAKAPGISKKLAELIYATLHSE
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A4XUW4
Q601T9
TMCAL_MESH2
tRNA(Met) cytidine acetate ligase
Mesomycoplasma
MAIAIIAEYNPFHNGHIYQLEYTKKNFPNDKIYIILSGNFTQRGEISLADFKTKSKIALKYGADFIIKLPFEYATQAAHIFAKGAIKIVNQHKIDKIIFGSESNDVENLYKLANLWNQNQEAYNAFLKYALKLGYSFPKASAFALEEISGQKIVFPNDILGFEYIKQIVANNYPIRAYTLKRSEEFSLKNPEPNIASATYLRQLVNENKSISRFSPMKFIHPVCSLANLYPEFQKIVRETSAENLAKIWLISEGIENLFKKHINEPNFEKFLNAVNSRRYTNSRIKRAMVYILFRIEDPSQFDEEKIQLDCWKNQGF
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
Q601T9
Q5L6W5
YIDD_CHLAB
Putative membrane protein insertion efficiency factor
Chlamydia
MSFKQLLYNLPTHLCCGLIHLYRWTISPLLGSPCRFFPSCSQYALQALKHHKCIRGLWLTIKRIGKCGPWHPGGIDLVPMTTLEEALDVSQVTNDDDSGDSHA
Could be involved in insertion of integral membrane proteins into the membrane.
Q5L6W5
Q05938
TOXR_VIBPA
Cholera toxin homolog transcriptional activator
Vibrio
MTNIGTKFLLAQRFTFDPNSNSLADQQSGNEVVRLGSNESRILLMLAERPNEVLTRNELHEFVWREQGFEVDDSSLTQAISTLRKMLKDSTKSPEFVKTVPKRGYQLICTVERLSPLSSDSSSIEVEEPASDNNDASANEVETIVEPSLATTSDAIVEPEAPVVPEKAPVASAVNPWIPRVILFLALLLPICVLLFTNPAESQFRQIGEYQNVPVMTPVNHPQINNWLPSIEQCIERYVKHHAEDSLPVEVIATGGQNNQLILNYIHDSNHSYENVTLRIFAGQNDPTDICK
In the presence of ToxS, promotes the expression of the thermostable direct hemolysin 2. May be a global regulator.
Q05938
A4QKK3
YCF4_CAPBU
Photosystem I assembly protein Ycf4
Capsella
MSWRSESIWIEFITGSRKTSNFCWAFILFLGSLGFLLVGTSSYLGRNVISLFPSQQIIFFPQGIVMSFYGIAGLFISCYLWCTILWNVGSGYDLFDRKEGIVRIFRWGFPGKTRRIFLRFFMKDIQSIRIEVKEGVSARRVLYMEIRGQGAIPLIRTDENFTTREIEQKAAELAYFLRVPIEVF
Seems to be required for the assembly of the photosystem I complex.
A4QKK3
Q04FR4
TYSY_OENOB
Thymidylate synthase
Oenococcus
MSRNEEQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLWFLRGDNNIRFLLQHHNHIWDEWPFKKWVESNEYKGPDMTDFGLRTQKDPIFAEQYKEQKKIFVDRILNDDEFSKKFGTIGDVYGKLWRHWPDANDDGSVDQITRLINEIKVNPNSRRLILTAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAAQTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLENYIHEDVIKAPIAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q04FR4
V9VGU0
VCL_PINKO
Vicilin-type seed storage protein
Pinus subgen. Strobus
MAFVSLLTILLAISSSSVALTEPVASMADQGVFPEQHGRGHHGVFPEEHGRGHHRGGREEEREENPYVFHSDRFRIRASSEAGEIRALPNFGEVSELLEGISRYRVTCIEMKPNTVMLPHYIDAKWILYVTGGRGYIAYVQQNELVKRKLEEGDVFGVPSGHTFYLVNNDDHNSLRIASLLRTESTMRGEYEPFYVAGGRNPETVYSAFSDDVLEAAFNTDVQKLEHIFGAHRRGVIFYANEEQIREMMRRGGFSAESTSASEQPKPFNLRNQKPDFENDNGRFTRAGPKDNPFLDSVDVTVGFGVLNPGTMTAPSHNTKATSIAIVMEGEGRIEMACPHLGQEHGWSSPRERGHQDINYERVRARLRTGTVYVVPAGHPITEIASTNGRLEILWFDINTSGNEREFLAGKNNVLQTLEKEVRHLSFNIPRGEEIEEVLQAQKDQVILRGPQRQRRDEPRSSS
Seed storage protein.
V9VGU0
A1WZH9
TSAC_HALHL
tRNA threonylcarbamoyladenosine biosynthesis protein TsaC
Halorhodospira
MNECPPGTRPFRVRHAAAELRQGGVVAYPTEAVWGLGCDPRNADAVARLLALKGRPERQGLILIAAESRQLARYLAPLPAEWAETIQASWPGPMTWVLPASTRAPRWVSGGRDTLAVRVTAHPVAAALCSAFGGALVSTSANPSARRPARSVAEVRRYFGTRIDALVPGRLGGLERPTPIRDGRSGAYLRR
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
A1WZH9
A7I4T7
TRPD_METB6
Anthranilate phosphoribosyltransferase
Methanoregula
MTMKEAIATVVEGRDLAPAQAAAVMNMMMDGQATPAQIGGFLTALRAKGETPEEIAAFARVMREHTVHVKPRVSGTLVDTCGTGGDGAQTFNISTAAAFVAAGAGITVVKHGNRSVSSRCGSADVLTALGVDISVDPGRQAGIVQETGIIFLFAPSHHPAMKHVMATRQDLGCRTVFNLLGPLANPAGAAAQVLGVYDQKLTGPMAEVLSLLGVSRAMVVFGSGLDEITVTGETSVTELANSRITNYIVTPEQFGFTRAAPGDLLGGDPEKNARIIRAILDGAPGPARDIVLMNAGAAIYVGGRAATLAEGIRHAAESIDSGKAAGKLAALVTATRGAS
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
A7I4T7
Q9ZRB1
TBB2_WHEAT
Beta-2-tubulin
Triticum
MREILHIQGGQCGNQIGAKFWEVVCDEHGIDPTGRYTGTSDLQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPTGLSMASTFVGNSTSIQEMFRRVSEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATSDEEGEYEDEDQEPEEDM
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9ZRB1
B9DM46
TRUA_STACT
tRNA-uridine isomerase I
Staphylococcus
MRILVKISYQGSNFLGFQIQQHGRTVQQQFEKILKRMHKRHVRIHPSSRTDRGVHAIEQYFHFDTELNIAPDKWQYAMNSALPDDIYVNEVSIVDDDFHCRYDCVGKRYRYKVYQGKHRDVFMSGLKTFYADSLDLEKMNEAAQQFIGTHDFTGFCSQKTEVESKERTLYQSEIIKTENGFDYIVTGSGFLYNMVRVLVAFLIEVGKGKRQPEEVPILLEAKDRKQVPFTAPAEGLYLEKIYLAPQELINDFGPDIKIHRKKSLEND
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
B9DM46
Q47HQ5
TRPB_DECAR
Tryptophan synthase beta chain
Dechloromonas
MSQYNFPDAKGHFGPYGGVFVAETLFGALDELKEAYAAAQADPAFRAEYEYELKHFVGRPSPIYHAKRWSEMLGGAQIYLKREDLNHTGAHKVNNCIGQAMLAKRMGKPRVIAETGAGQHGVATATVAARYGMECVVYMGSEDVKRQAANVYRMKLLGATVVPVESGSKTLKDALNEAMRDWVTNIHNTFYIIGTVAGPHPYPMLVRDFQKIIGEECLVQMPEMTGRQPDAVIACVGGGSNAMGIFYPYINVEGVRLIGVEAAGDGMETGRHSASLTAGVPGVLHGNRTYLLQDEDGQIIETHSVSAGLDYPGVGPEHAWLKDLGRAEYQPVTDSEALAAFHTLCRIEGIIPALESSHALAYAAKLAPTLAKDKILLVNLSGRGDKDMHTVAEKSGIVF
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q47HQ5
Q0HHA0
TIG_SHESM
PPIase
Shewanella
MQVSVEATQGLERRLTISVPAEQIEKLVKDSLQREAKRARIPGFRPGKVPVTVINKRYGAAIRQDITGEVMQRNFIEAIIAEKLNPAGAPTFVPGATDGEKFEFVATFEIYPEVELKGLDAIEVEQPKASVTDADVDSMIETLRKQHATFAAVEREAADGDKVKMNFVGSVDGVEFEGGKADDFELQLGSGRMIPGFEAGILGHKAGEEFVIDVTFPEEYHAENLKGKAAKFAITLTEVLAANLPEVNDEFAALFGISEGGLEALKTEIRKNMNRELEQALKANVKEQVINGLLANNDIELPKALIDGEVNVLRQQAMQRFGGQTANMPELPAELFTEQAARRVKIGLLLGEVIKTNELKAEDERVQALIASMASAYEDPSEVVAYYNSNKELMQNMRNVALEEQAVEALLKSAKVTEKEVAFEEFMNKATGRA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q0HHA0
O95932
TGM3L_HUMAN
Transglutaminase-6
Homo
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
O95932
A2C0L6
YIDD_PROM1
Putative membrane protein insertion efficiency factor
Prochlorococcus
MLTKINKAIALVFVSLISFYQKWISPLFGPSCRFIPSCSAYGIEAVNKHGPWRGGWLTLKRLSKCHPFTPCGCDPVPEK
Could be involved in insertion of integral membrane proteins into the membrane.
A2C0L6
Q4A898
TMCAL_MESH7
tRNA(Met) cytidine acetate ligase
Mesomycoplasma
MAIAIIAEYNPFHNGHIYQLEYTKKNFPNDKIYIILSGNFTQRGEISLADFKTKSKIALKYGADFIIKLPFEYATQAAHIFAKGAIKIVNQHKIDKIIFGSESNDVENLYKLANLWNQNQEAYNAFLKYALKLGYSFPKASAFALEEISGQKIVFPNDILGFEYIKQIVANNYPIRAYTLKRSEEFSLKNPEPNIASATYLRQLVNENKSISRFSPMKFIHPVCSLPNLYPEFQKIVRETSAENLAKIWLISEGIENLFKKHINEPNFEKFLNAVNSRRYTNSRIKRAMVYILFRIEDPSQFDEEKIQLDCWKNQGF
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
Q4A898
Q6CL17
VPS27_KLULA
Vacuolar protein sorting-associated protein 27
Kluyveromyces
MALPSMSVSEFDALIEQCTNEKIPNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTRNNQNLQFSVWRLVEVCMKNGGVPFLKEVCSREFMDCLEQVILAESTDYELEQFCSRLVGELYLAFKNDSQLSYVVKVYQKLVSRGIDMENLKPTENLNAMFDAKTPADWIDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFEDYDLKRKSSKGKKSKGKKRFTRSEDDDEDLRRAIELSLKENGRDADTFIPDTAKLEPLKKDPDEEDPDLKAAIEASLREHQQEEMRRKSQAKNMYNTSSPSVAPPIENNYDLSSNEEEDIHLFASLVERMKTQPPTAVLEDTQLQQLYQKVLGVRPKLNYALSDTVSKYNTVYEMNSKISDIMNMYDSMLEMQLRNISLSQQYAIPESGRNSYGYHQNMPQYDQPNSPQIIAQPQIHSPQQNERTILNYASPVSQHLSNGATTNTYQQGSALQNQQPAAPEPQPVSFEKPSTTSQLEGLILEEPSEPPYPDENTTIENPKIEQASERPYPDDHLKQENITSFDFPTVPLRKLSIHGSEQEVKEEPVQQEQLLIEL
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Q6CL17
B0S0L6
THIM_FINM2
4-methyl-5-beta-hydroxyethylthiazole kinase
Finegoldia
MDNLIQKMSEIYSDLHNSNNLIHCLTNAISINDMANAVLSIGQSPFMADNPREVEDVTRKSDSLLVNLGNITDYRIESIKKSVRIANENNIPITLDLVGVSASKLRLDLTLDILKNHTITCIKGNYSEIKSLFIKDLSTKGVDSQKLEVDDVINCCKNLHEKYDSIIVATGQTDIVCANEIYLLNNGDDRLSKITATGCVVGSLIACTLSVSQSIKACVLAISMMNISCEMVDKSVGLSSFKLGLYDNLSRIKWEQIKENIDAKKVES
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
B0S0L6
P0C2E9
TACY_CLOPE
Thiol-activated cytolysin
Clostridium
MIRFKKTKLIASIAMALCLFSQPVISFSKDITDKNQSIDSGISSLSYNRNEVLASNGDKIESFVPKEGKKTGNKFIVVERQKRSLTTSPVDISIIDSVNDRTYPGALQLADKAFVENRPTILMVKRKPININIDLPGLKGENSIKVDDPTYGKVSGAIDELVSKWNEKYSSTHTLPARTQYSESMVYSKSQISSALNVNAKVLENSLGVDFNAVANNEKKVMILAYKQIFYTVSADLPKNPSDLFDDSVTFNDLKQKGVSNEAPPLMVSNVAYGRTIYVKLETTSSSKDVQAAFKALIKNTDIKNSQQYKDIYENSSFTAVVLGGDAQEHNKVVTKDFDEIRKVIKDNATFSTKNPAYPISYTSVFLKDNSVAAVHNKTDYIETTSTEYSKGKINLDHSGAYVAQFEVAWDEVSYDKEGNEVLTHKTWDGNYQDKTAHYSTVIPLEANARNIRIKARECTGLAWEWWRDVISEYDVPLTNNINVSIWGTTLYPGSSITYN
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A major conformational change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host cell membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.
P0C2E9
Q6D075
YQGF_PECAS
Putative pre-16S rRNA nuclease
Pectobacterium
MSNRTLLAFDFGTKSIGVAIGQEITGTARALTSFKAQEGIPDWQKVEKLLSEWQPDLVVVGLPLNMDGTEQPLTARARKFANRLHGRFGVAIELHDERLSTVEARADLFERGGFKALDKGSVDAASAVIILESWFEAQH
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q6D075
B7V362
THIC_PSEA8
Thiamine biosynthesis protein ThiC
Pseudomonas
MSATQKNNITRLEQLDRQSTQPFPNSRKVYLTGSRPDIRVPVREISLADTPTAFGGEKNPPVFVYDTSGPYTDPEVRIDLRKGLPDVRSRWIDERGDTEILPGLTSEFGQARLADASLDALRFAHVRTPRRAKPGANVSQMHYAKKGIITPEMEYIAIRENMKLQEARAAGLLDQQHPGHSFGANIPKEITPEFVREEVARGRAIIPANINHTELEPMIIGRNFLVKINGNIGNSALGSSIEEEVEKLTWGIRWGADTVMDLSTGKHIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHQENFLYTHFEEICEIMKAYDVSFSLGDGLRPGSVADANDAAQFGELETLGELTKIAWKHDVQVMIEGPGHVPMQLIKENMDKQLECCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKDDVKTGIITYKIAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDTARAFHDETLPKDSAKVAHFCSMCGPKFCSMKITQEVRDYAKENGLSDESKAIEAGFQEQAARFKDEGSVIYRQV
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
B7V362
P40746
TGL_BACSU
Transglutaminase
Bacillus
MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAELMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAIRDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTETGHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFRKKGALQSAYLLSQATRLDVPSLFRIVR
Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links. In wild-type spores at 37 degrees Celsius, tgl mediates the cross-linking of GerQ in higher molecular mass forms, probably in cooperation with YabG.
P40746
B1YJJ2
THIM_EXIS2
4-methyl-5-beta-hydroxyethylthiazole kinase
Exiguobacterium
MLRRIHDKKPLIHHLTNTVTINDCANMTLALGGSPVMAEDLLEVEEMVGLADAVVINTGTINPDMRKAQLLAGKTANRLGKPVILDPVGAGATTLRTDFMKQLMEEITFTVIKGNASEIKTLLGQAARTKGVDVAEGESLDLQSVHAFASQTKQVIVVTGPVDFVTDGVRQHHLDVGTKRLGQVTGTGCMTASLIATFLGAGYGRFDAAVFGTYAMGKAGETAGNRPGIGSFRTGLFDAVSLMTEESLPEVQMNGQ
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
B1YJJ2
Q53H54
TYW2_HUMAN
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
Homo
MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Q53H54
Q9XCW4
VIOA_ECOLX
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Escherichia
MNDKTIPVTQPSLPELAEFMPYLEKIWKNKWLTNNGPFHQELEEKLCEFLGVQHISLFNNATIALITALQALRITGEVITTPYSFVATSHAILWNGLTPVFVDIENDGYNIDYRKIEQAITPKTSAILPVHCYSTPCEVEEIQKIADNYGLKVIYDAAHAFGVNFKGGKVYLTMVIYQFLVSMRRKSSINFEGGAIISPDAKTKLRIDRLKNFGIADELTVTAPGINGKMSEINAAFGLVQLKHIEGSISKRKIIDSLYRNLLKGTPGITIFPGNINTNSNYSYFPILIDDGFHMSRDQAYELLKKNNILSRKYFYPLISNMPMYRGLISASVDNLPIANSVADKVLCLPIYTDLNEEIVVKITKLLLGKM
Catalyzes the conversion of dTDP-4-dehydro-6-deoxy-D-glucose (dTDP-D-Glc4O) to dTDP-4-amino-4,6-dideoxy-D-glucose (dTDP-D-Qui4N).
Q9XCW4
Q815A2
TAGU_BACCR
Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU
Bacillus cereus group
MKKKILFWILGIIGILIIGGGAYAYSIYSSVSKTLDEVHKPLKRDKDSKGTEEVKISKSEPVSILLLGVDERGNEKGRSDSLILITLNPKNNSMKTVSIPRDTYTEIVGKGKSDKINHAYAFGGVDMSVATVEKFLNVPINYYIEVNMAGFKDIVDAVGGVDVNNDLEFKQDKHHFAKGNIHLTGDEALSFTRMRYEDPRGDFGRQMRQRQVMQAVIKKGATFSSLTSYGDVLTAIQKNVKTNLTQDQMFDMQKNYKNCLENSEDIQIPGDGHKAADGIWYYYVPEAAKQDLTNKLRAHLEVTK
May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
Q815A2
Q15776
ZKSC8_HUMAN
Zinc finger protein 192
Homo
MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHESNPLGQEVFRLRFRQLRYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVPQESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQKDLCRDNRPENFRNMFSLGGETRSENRELASKQVISTGIQPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
May be involved in transcriptional regulation.
Q15776
B9M422
UVRC_GEODF
Excinuclease ABC subunit C
Geotalea
MIEIDSIGHFPSSPGVYIMKDAEATVLYVGKARDLRKRIRSYFAASGDSRYQIRFLMARVTDIQFIVTDTEKEALILENTLIKKYRPKYNFNLRDDKTYFSLRMDMSSDFPRLSIIRKVTRDGARYFGPYSSASDARAVLKHLYKLFPLRHYPMETCRRRNRPCLFYQLKQCSAPCHGKISREDYMALAEGAALFLEGKNREILKIFRERMSAAAAAEKYEKAARFRDLIRSIEVTVEKQKVVAQGGDSDVIGFYREGEQLHIALLFLRGGTLTGSRNYSFSWEMDDHEGIASFLNEYYNQEVFIPSEIVLPIAIADPLPQEELLCELRGRRVSITVPQRGNKLELVRLAIKNAETAAAERKKAAESGEAILQTLKERLHLHKLPRRIECYDISNIQGQMAVGSKVAFVDGKADKAHYRRYRIKGVSQSDDFAMMREMFSRRFKPGTAPDDYPDLIIVDGGIGQLNVLTHVLGDLQITDVEAAGLAKSRVDREMGATEISRSDERVFLPNRKNPVVLRQNSAPLLLLARIRDEAHRFAVAYHKKLRGNKLLASQLEAIPGIGIKRRKELLRHFGSLKKISEATLEELRQVQGISATVAESLWKHLHENEKGDTNASPFVNFE
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
B9M422
Q0TPH6
YQGF_CLOP1
Putative pre-16S rRNA nuclease
Clostridium
MRILGLDIGSKTIGVAVSDPLGWTAQGVTTIKRDCYTKDVEAVMKICKEYGVETIVAGMPKNMNGTIGPSGEMVKNLCEQIEKSFDGKIEFWDERLTTVAAHRAMLEADLSRAKRKKIVDKIAATYILQGYLDRISK
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q0TPH6
Q8CPZ0
UVRB_STAES
Excinuclease ABC subunit B
Staphylococcus
MVEHVPFKLKSEFEPQGDQPQAIQKIVDGVNERKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSSLFERDDVIIIASVSCIYGLGNPEEYKNLVVSVRVGMEMERSELLRKLVDVQYSRNDIDFQRGTFRVRGDVVEIFPASREEMCIRVEFFGDEIDRIREVNYLTGEVIREREHFTIFPASHFVTREEKMKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQIRGMYNGDRARKQVLIDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYELEHTDEMVEQIIRPTGLLDPKIDVRPTENQIDDLLSEIQDRVDKDERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDAIVGINLLREGIDIPEVSLVVILDADKEGFLRSDRSLIQTIGRAARNDKGEVIMYADKITDSMQYAIDETQRRREIQIAHNKEHGITPKTINKKIHDVISATVESDETNQQQQTELPKKMTKKERQKTIENIEKEMKKAAKDLDFEKATELRDMLFELKAEG
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q8CPZ0
P0CI04
TX132_APHSP
Peptide 7-13.2
unclassified Aphonopelma
CLGENVPCDKDRPNCCSKYECLEPTGYGRCYASYYSYKKKTL
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells.
P0CI04
A1W0N0
UVRC_CAMJJ
Excinuclease ABC subunit C
Campylobacter
MTKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSLRIQKMIEETVHLEFITTNSEADALILENSFIKQLHPKYNILLRDDKTYPYIYVNFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQKASCKSPCIFYQISRCLAPCDKRISKEKYLEILDEAMHALLNPSILIKNLEKQMLVLAQNENYEEAAKVRDQIVTIKDLEVKVEMDVAKLEDFEVFALAFEDSMLSTLRFVVQNGKIISANSKITPIKNDIQWDQNEIYKQLILENFSMDIPLLANVIYVYEEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNSHLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKVLLDLAKKIIVSSGANVDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLSSGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A1W0N0
Q9GZ69
TPM_MIMNO
Allergen Chl n 1
Mimachlamys
MDAIKKKMQAMKVDRENAQDLAEQMEQKLKDTETAKAKLEEEFNELQKKLTATENNYDTVNEQLQEANTKLENSEKQITQLESDVGGLQRRLTLLEEDYERSEEKLNSTTEKLEEASKAADESERNRKVLEGRSNSYEERIDELEKQLETAKNVATDADHKFDEAARKLAITEVDLERAETRLEAADAKVLELEEELTVVGANIKTLQVQNDQASQREDSYEETIRDLTKSLKDAENRATEAERQVVKLQKEVDRLEDELLAEKERYKAISDDLDQTFAEIAGY
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Q9GZ69
C0MBD7
UVRB_STRE4
Excinuclease ABC subunit B
Streptococcus
MIDKRDFKAFKLVSKYAPSGDQPQAIETLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVVAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDQLLNALVDIQFERNDIDFQRGRFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGKVLGDADHLVLFPATHFVTNDEHMEQSISKIQAELADQLKLFEAEGKLLEAQRLRQRTEYDIEMLREMGYTNGVENYSRHMDGRSAGEPPYTLLDFFPDDFLIMIDESHMTMGQIKGMYNGDKARKQMLVDYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRPTGLLDPEVEVRPSMGQMDDLLGEINLRVERGERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNADGHVIMYADRMTDSMQRAIDETARRRAIQMAYNEEHGIIPQTIKKDIRDLISISRAVEAKATEAETNYESMTRSERQEAIKQLQKNMQEAAELLDFELAAQLRDLILELKAMD
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
C0MBD7
Q944Q0
WNK8_ARATH
Protein kinase with no lysine 8
Arabidopsis
MASGSGFLGQISSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLLSDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQSMKSDISADYYFPYSANDGNAAMEAGRDAESMSSYLDSCSMMSTIYNLSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVNIS
Regulates flowering time by modulating the photoperiod pathway. Phosphorylates the vacuolar ATPase subunit C (VATC) and RGS1 . Regulates EDM2 that, in turn, modulates development processes .
Q944Q0
Q57955
Y535_METJA
Uncharacterized protein MJ0535
Methanocaldococcus
MVSIMPKILYNPEVLGHKPKSYHVENPERVLTILNSLKSNGFDDIVLIEGKSTINEILEIHSRDYVYSIINLSKSFNYYDGDTYLCDRTLDAALTAFKLAKEAVKLALKDRDLYFALTRPPGHHAGISGRALGAMSNGFCIFNNIAGAARLAKNYMKKVIIIDFDVHHGNGTQEIFWNDNRVIHIDFHQRGIYPGTGDILDIGGEEAKGTKINLPFPAHSTDADYIFAWNEIVEPILNYFSPDTVLVSAGFDAFINDGLASMDLTETFYRFVGAKLSGYSVTAVLEGGYSIGLKYAPPAFLDGYVDAKDVLDNLEDYTVINSNEVKSMVKNVKKIIGEYLDIF
Putative deacetylase.
Q57955
P17794
VIRB4_AGRFC
Protein virB4
Agrobacterium tumefaciens complex
MLGASGTTERSGEVYLPYVGHVSDHIVLLEDGSIMTMAHVSGMAFELEDAEMRNARCRAFNTLLRNIADDHVSIYAHLVRHDDVPPSPARHFRSAFSASLSEAFEERVLSGKLLRNDHFLTLIVSPRAALGKVRRRFTKRYRQKENDLTAQTRNLEDLWHLVAGALEAYGLRRLGIREKQDVLFTEVGEALRLIMTGRFTPVPVVSGSLGASIYTDRVICGKRGLEIRTPKDSYVGSIYSFREYPATTRPGMLNVLLSLDFPLVLTQSFSFLTRSQAHSKLSLKSSQMLSSGDKAVTQISKLSEAEDALASNEFVLGAHHVSLCIYANDLNNLADRGARARTRLADAGAVVVQEGIGMEAAYWSQLPGNYKWRTRPGAITSRNFAGLVSFENFPEGSGSGHWGNAIARFRTNGGTPFDYIPHEHDVGMTAIFGPIGRGKTTLMTFILAMLEQSMVDRAGAVVLFDKDRGSELLVRATGGTYLALRRGAPSGLAPLRGLENTAASHDFLREWIVALIESDGRGGISPEENRRLVRGIHRQLSFDPHMRSIAGLREFLLHGPAEGAGARLQRWCRGNALGWAFDGELDEVKLDPSITGFDMTHLLEYEEVCAAAAAYLLHRIGAMVDGRRFVMSCDEFRAYLLNPKFAAVVDKFLLTVRKNNGMLILATQQPEHVLESQLGASLVAQCMTKIFYPSPTADRSAYIDGLKCTEKEFQAIREDMAVGSRKFLLKRESGSVVCEFDLREMREYVAVLSGRANTVRFADQLRKVQGDNPSAWLSEFMARYHEAKD
A possible function of virB4 might be to provide the energy, via hydrolysis of ATP, for translocation of virulence proteins of the transfer of a T-DNA-protein complex across the agrobacterium membrane.
P17794
O13267
WNT5A_PLEWA
Protein Wnt-5a
Pleurodeles
MASRYLTLAAALLASFLQVDIEANSWWSLAMNPVQIPEAYIVGAQPLCSQLAGLSPGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNISVFGRVMQIGSRETAFTYSISAAGVVNAVSRACRAGELSTCGCSRARRPKDLQRDWLWGGCGDNLDYGYRFAKEFVDAREREKIHQKGSYESSRTLMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDFLKEKYDSAASMKLNSRGKLVQVNSRFNPPTTNDLVYVDPSPDYCVRNESTGSMGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis.
O13267
Q65P74
TRUA_BACLD
tRNA-uridine isomerase I
Bacillus
MRMKCTISYDGHLFYGYQVQPGQRTIQDELEKALQTLHKAKERIPVVSSGRTDSGVHAVGQTIHFDSPLSIPEAKWPYALNALLPDDISVRKAEAVNDQFHARFSAKRKEYRYMIYRGRHPDVFKRYYAYHVPYDLDMEKVKEASRYLVGTHDFTSFCATKTEVKDKVRTVHELEWSDTGDGLQMRIVGSGFLYNMVRIIAGTLLDVGTGKFSPGDIEKMILAKNRDAAGRTAPAHGLYLWRVIYDN
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q65P74
Q9DBS2
TPRGL_MOUSE
Protein FAM79A
Mus
MLQLRDTVDSAGTSPTAVLAAGEDAGAGRPGAGTPLRQTLWPLNVHDPTRRARVKEYFVFRPGTIEQAVEEIRAVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTDQSLLICKYDFISLQCQQVVRVALSAVDTISCGEFQFPPKSLNKREGFGVRIQWDKQSRPSFINRWNPWSTNMPYATFIEHPMAGMDEKTASLCHLESFKALLIQAVKKAQKESPLPGQANTVLVLERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF
Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.
Q9DBS2
Q40289
UFOG7_MANES
UDP-glucose flavonoid 3-O-glucosyltransferase 7
Manihot
TLNLIPGMSKIQIRDLPEGVLFGNLESLFSQMLHNMGRMLPRAAAVLMNSFEELDPTIVSDLNSKFNNILCIGPFNLVSPPPPVPDTYGCMAWLDKQKPASVAYISFGSVATPPPHELVALAEALEASKVPFLWSLKDHSKVHLPNGFLDRTKSHGIVLSWAPQVEILEHAALGVFVTHCGWNSILESIVGGVPMICRPFFGDQRLNGRMVEDVWEIGLLMDGGVLTKNGAIDGLNQILLQGKGKKMRENIKRLKELAKGATEPKGSSSKSFTELANLVRSRGSYEN
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments.
Q40289
A6WM46
TOLB_SHEB8
Tol-Pal system protein TolB
Shewanella
MRILAKWLALAVLLCTTPAKAALDIVITEGVDAARPIAVMPFVWQGPGAAPQAIADVVMSDLVRSGTFKPLDELGLPQRNIGTVAQFQANSWSSVGAEALVLGTVKPYGTDQYLVSFDLIDLVKAQNQALKGPVSATEFLMDSRQTVISAAQFRQYGHRISDIVYEKLTGIRGAFLTRISYVVVNHTQKAPYQLMVADYDGVNEQMLLRSPEPLMSPTWSPDGRRLAYVSFENKKAEIFVQDLYTQVRTKVSSFPGINGAPAFSPDGKSLAITLSKDGQPEIYIIDIATKAIKRITNHYAIDTEPSWYPDGKSLIFTSERGGRPQIYRVELSSGKVSRETFEGEWNLGGSITPDGRSMIFVNRTNGKFNIARMDLSTRFMQVLTSTRLDESPSVAPNGTMVIYGTTYQGKQVLAAVSTDGRFKARLPAGQGEVKSPSWSPFL
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
A6WM46
A4Y3A9
Y712_SHEPC
Nucleotide-binding protein Sputcn32_0712
Shewanella
MKLVIVSGRSGSGKSVALRVLEDLGYYCVDNLPLPLIGSLLEQLKGSNDLVAISVDVRNMPEQDKVLVQQLSNLPAGTEITSFFLNSSDKVLLKRYSETRRLHPLSKSRVSLQEAIKLEGKLLEPMSKLVDHYIDTSNLNIYDLSDQVRQILLGSVDKELVIYFESFGFKNGMPTEADFMFDVRFLPNPHWELALRPLTGLDEPVAEFLNRQPLVNKFIWQIENLLETWLPHLERNNRSYLTIAIGCTGGQHRSVYVAEQLAKRFSNGKHKVNVRHRELDNAKA
Displays ATPase and GTPase activities.
A4Y3A9
B0M1H3
ZIP4L_ARATH
Protein ZIP4 homolog
Arabidopsis
MRIAEITTPDLRLHHRETDSHTHHPLLSEIELLIQQSEAISKDQPLPQSLPISLRQFLTRLSQLAPFPDNSFKLTIWKLSFRLWNACVDLANAASLQSSLTSAENIANLRHVAADMLFLAKDVTGVPSPTIKSSLFYYKTGLVYHSLKKFDLASDCFERATEIVSKIDIAKISDAGEKKLFLDLNLARSRTAWEISDRNLAVTLLNRAKNLLFGSPDHYKSLSNQFLAFGKSSLSRGDDDCSLNDALRLMNEALDLCEKGLGTAKTREDTTEFTAMRIKTLRFISAVHLQKGEFENVIKCVKVLRNGGNGSDGADQHASLPVLAMKAWLGLGRHSEAEKELRGMVGNNDIPEAVWVSAVEAYFEVVGTAGAETAKGVFLGLLGRCHVSAKAALRVAHRVLGESRGGDNGSRIRANVVAQLVSDERVVALFASEAVTKERKAIHSVLWNSASDHFRAKDYETSAEMFEKSMLYIPHDIENRVFRAKGFRVLCLCYLGLSQLDRALEYIEEAEKLEPNIACSFLKFKIYLQKKEHSCAIGQIDAMTSCLDFSPDYLSLSAHEAISCQALPVAVASLSKFLSFYISGKKMPTTEVVVFRTLVTILTQDIGSETEALNFMLQAQSRASKLGTECFFGLGETGKREQNWFAATCWNLGSRCGKEKKYELCGEFLRLASEFYGYIDTDESGEDKLMICRSIILSVTAMIALEKQTKSALTETQVKLAAELLVRAGKIMSSSLSDGKDCIMEPELIFMYTLLAYDIHGRLNNSAFQLLVVKTFAGSKSCHYNYLLQLGIFASQSPQSNPDVSTFALNECLSALIASASPEYPTIALIIRKLISIASVHKGDTDDEEAILKMYKQAYRIMVGLKEGEYPTEEGKWLAMTAWNRAALPVRLGQFETAKKWLSIGLEIADKVTGMDTYKACMQDYLAGFQTKVSSA
Required for meiotic chromosome segregation. It is involved in interference-sensitive crossovers (class I meiotic crossover) formation, in both male and female meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover). Not required for synapsis completion.
B0M1H3
A1JJ98
TYPH_YERE8
TdRPase
Yersinia
MFLAQEIIRKKRDGQALSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGPMVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDSAFRKIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYQLSEDLAKAIVGVANGAGCKTTALLTDMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAQNDADARAKLQAVLDNGKAAEIFGRMVAAQKGPSDFVERYDSYLPAAMLSKPVFAERSGIITAMDTRALGMAVVSLGGGRRRATDPIDYSVGLTEMARLGASVDGQQPLAVIHANNEDDWQQAADAVRAAITLGQKAAEETPVVYRRITE
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
A1JJ98
Q868G6
TACHY_APIME
Tachykinin-related peptide 7
Apis
MIIHSIFLLMVSITLVIAEESDNVLFDKRAPTGHQEMQGKQNSASLNSENFGIFKRALMGFQGVRGKKNSIINDVKNELFPEDINKRAPMGFQGMRGKKASFDDEYYKRAPMGFQGMRGKKSLEEILDEIKKKTTRFQDSRSKDVYLIDYPEDYGKRVLSMDGYQNILDKKDELLGEWEKRAPMGFYGTRGKKIILDALEELDKRGVMDFQIGLQRKKDTTFDDYLDYAINPFDYEKRSTDFQDVESGSESFKRARMGFHGMRGKRDAAGIYGSNSSTVGTIFGYQDMRNRGNNFPVYQVEKRSPFRYLGARGKKNPRWEFRGKFVGVRGKKSSLQTVF
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Associated with sex-specific or age/division of labor-selective behavior and/or physiology of honeybees.
Q868G6
B0TT74
UREG_SHEHH
Urease accessory protein UreG
Shewanella
MTELEYKQPLRIGVGGPVGSGKTALLEVLCKALRNKYQIAVVTNDIYTQEDAKILTRAEALDADRIIGVETGGCPHTAIREDASMNLAAVEELAKRHKNLDVVFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITRSDLLIINKIDLAPYVGASLVVMDQDTKRMRPEKPYIFTNMKTGKGVPEILTFIETAGMLNI
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
B0TT74
P54402
TBG_EUPAE
Gamma-tubulin
Euplotes
MPREIITCQVGQCGNQIGMEFWKQLCMEHGINPEGILEDFAVNGEDRKDVFFYQADDEHYVPRAVLIDLEPRVINCIQKSTYSSLYNPENIYIAKHGGGAGNNWGRGYTDAEKVQDEILEMIDREADGSDSLEGFVLTHSIAGGTGSGFGSYLLERINDHYPKKLIQTYSVFPIENDVVVQPYNCLLSIKRLTLNADCVVVLDNNALTSIAVDRLKILQPTFSQINSIVSTVMAASTTTLRYPGYMNNDMVGLIASLVPTPRCHFLMTGYTPLSLDQKYTSVRKTTFLDVMRRLLQTKNIMVTGAVKKGAYMSILNVIQGDVDPTQVHKSLQRIKERKLANFIPWGPASIQVALAKKSPYIDSGHKVSGLMLANHTGIRSIFKVLYDQYRTFRKRDAYMNIFKQTKIFEDNLDEFDSSDEVVKNLIDEYAAAEKMDYINWGNDDDDMQFDPREPPKFSNIQ
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
P54402
P33044
THHR_HORVU
Antifungal protein R
Hordeum
ATITVVNRCSYTVWPGALPGGGVRLDPGQRWALNMPAGTAGAAV
Has antifungal activity. Inhibits the growth of Trichoderma viridae and Candida albicans.
P33044
Q6NZL6
TONSL_MOUSE
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
Mus
MTLEQELRQLSKAKTRAQRNGQLREEAAYCHQLGELLASHGRFKDALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDIYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKPNQRVTVCQSLKYVLAVIQLQQQLEEAEGNDLQGAMAICEQLGDLFSKAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQLQRQILQHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEASEAPETSELELSESEDDADGLSQQLEEDEELQGCVGRRKVNKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMEERLQMASSGQASRSSPALQTIPSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRHRPTSSSSSSEDEDNPSPCRPSQKRLRHTTQQGEVKIPDPPKSRETATSSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVPAPKTALIPEEEYLAGEWLEVDTPLTRSGRPSTSVSDYERCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSVPRTSGPNKENYAAGQPLLLVQPPPIRVRVQIQDNLFLIPVPQSDIRPVAWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEVLAEVTSWDLPPLKDRYRRACLSLGQGEHQQVLHAMDHQSSSPSFSACSLALCQAQLTPLLRALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGQEGLRQLVEGSSGQAALQNLEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSSSFFLSHQAALGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPACTLKRLDLSSVAASKSNSGIIEPVIKYLTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVSCASLEELLSALQERSQGLSFLGLSGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKDRDSVCQRLPEGACTMDQSSKLFFKCL
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1.
Q6NZL6
B4G535
TOTZ_DROPE
Protein Turandot Z
Sophophora
MSRLIHLSFVLALLACLTGTISANPIDDDRDRLNQLLSNPEPADDAELLRNTQEAIALYKKHARRTLPGHQVELDLDRDIRAFETENLTVDGLPIQGGVWDLIKKGADKVPDEVKDQAKELAKTTAKALFNKLTEYLKKKISGEDAAKKDT
A humoral factor that may play a role in stress tolerance.
B4G535
Q0VTA7
UBIA_ALCBS
4-HB polyprenyltransferase
Alcanivorax
MFAFVEQRYPTLWPYIQLMRLDRPIGTLLLLWPTLWAVWIAGAGTPSLTVIVVFFLGVVIMRAAGCVINDFADRNFDGDVERTQGRPLATGALSAKQALALFGGLGLLAFGLVLFLNELTFWLSFGGLGLAVLYPFTKRFTFMPQLFLGAAFSWAIPMAFAAETGEVPEIAWLLYVANVLWTVAYDTEYAMCDREDDLKLGIKSTAILFGDADRLMIAILQALTLLALIMVGHRLGFSWPWYAGLVGMSLSFAFQHSLIRYRERWPSFHAFLNNHWAGACVFIGLYFQYF
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Q0VTA7
Q0VMA0
TATA_ALCBS
Sec-independent protein translocase protein TatA
Alcanivorax
MFSGISIWQLLILLAIVVLLFGTKKLRNIGGDLGGAVKGFKSAMKDGEDEQDHKRLADDDQPQNKQDAEQKAEQEKDKA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q0VMA0
Q9RPY1
VIRB4_BRUSU
Type IV secretion system protein virB4
Brucella
MGAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEELLIRKDQLNTLFRAIASNNVALWSHNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSNELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRKLDEIGNQIETSLRRYGGDDGRGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEIRTANATRYARGIDFKDYASHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQRLQNTEDGSASQIMEMDIAIDQLGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDNGFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGLSCFHNFRAGKRDGNPWGQALTLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHNAPMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVLVSRDGQHVTTTDESRISHAIRTVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKWCFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLDNADVRTPISMYLLHRMELAIDGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQQVATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGFDDELAILSGSSDNNELLDQVIAEVGDDPSVWLPVFQERRKARIASSKSTGR
The VirB system could be required for the establishment of the replication niche in the host.
Q9RPY1
Q08975
THI21_YEAST
Hydroxymethylpyrimidine phosphate kinase
Saccharomyces
MTYSTVNINTPPPYLALASNEKLPTVLSIAGTDPSGGAGVEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVSQILDANLQDMKCDVIKTGMLTTAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIASLITEKIAPFADILTPNIPECFKLLGEDREISKLRDIFEVAKDLAKITKCSNILVKGGHIPWNDEEGKYITDVLYLGAEQRFITFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAIEIPLEKMLSDECFTASDAVHKKPVKSSLNKIPGGSFYKYLINHPKVKPHWDSYVNHDFVRKVADGSLEPKKFQFFIEQDYLYLVNYARISCIAGSKSPCLEDLEKELVIVECVRNGLCQHERRLREEFGIKDPDYLQKIQRGPALRAYCRYFNDVSRRGNWQELVIALNPCLMGYVHALTKIKDEVTAAEGSVYREWCETYSSSWCHEAMLEGEKLLNHILETYPPEKLDTLVTIYAEVCELEANFWTAALEYE
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P.
Q08975
Q2SRU7
TRMD_MYCCT
tRNA [GM37] methyltransferase
Mycoplasma
MKFSIITLFPKIINSYIEESIIKRAINKQAIQIEIIDLRNFSTLNHNQVDDYQYGGGSGMVLMIEPLIKAIESVKTTKSIVLLTTPQGKTLNQSIVKTYSNNYEHIIIVCGHYEGYDERVLDYIDDEISIGDYVITGGELASLILVDSISRLLPNVIKQESYENESFENNLLDHPVYTKPYEFRNKKVPDVLLSGHHQNIKKWREEQQVIKTLKKRPDLIDITKLNKHQLEIYKKMKGEQ
Specifically methylates guanosine-37 in various tRNAs.
Q2SRU7
A3MV36
TBP_PYRCJ
TATA-box factor
Pyrobaculum
MSSKGPSYRIENIVATVNLGVELDLESLAERLPMAEYNPDQFPGLILRLTKPRISALIFRTGKMVCTGAKNEEDLKNAVRALVKLLNDHGAEVPFDPEVQIQNIVASGNLHAEVDLEQAVFMLENAMYEPEQFPGLIYRMSSPRVVILIFGSGKIVCTGAKSEKDVATAVQKLYNQLKELGVLYIEEGGGEEEEEEEEM
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
A3MV36
Q8CQ77
TARI_STAES
Ribitol-5-phosphate cytidylyltransferase
Staphylococcus
MIYAGILAGGIGSRMGNVPLPKQFLSLQGKPIIIHTVEKFLMYKDFDEIIIATPQKWINYMLDLLNNYQLDDKKIKVIQGGDDRNHSIMNIIESIEQHKKLNDEDIIVTHDAVRPFLTNRIIRENVEYASQYGAVDTVVNAVDTIISSNDAQFISGIPIRSEMYQGQTPQTFKIKELKDSYLSLTQSQKEILTDACKILVELGKPVKLVKGELFNIKITTPYDLKVANSIITGAVDND
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
Q8CQ77
B0TPX8
TOLB_SHEHH
Tol-Pal system protein TolB
Shewanella
MKIFGKWLLVTLLICSMPVKAALDIVITEGIDAARPIAVIPFVWQGTGPMPSQISDVVMSDLARSGTFSPADELSLPQRGISTLAQFNASAWMTQPAEAVVMGSIKPYGGDKYLVSFELIDLVKAQLQPDSQSAQDLVIDSRETIITAAQFRQYGHRISDVVYEKLTGIRGAFLTRIAYVVVNHGEKSPYKLMISDYDGYNEQMLLRSPEPLMSPSWSPDGQRLAYVSFENRKAEIYVQNIYTQQRTNVTSFDGINGAPVFSPDGKKLAVTLSKDGQPEVYVVDIATKAIKRVTNHYAIDTEPSWFPDGKSLLITSERGGRPQLYRVFLDSGKISRLTFEGEWNLGGSIAPDGRSIIFVNRTNGKFNIARMDLETRFMQVLTSTRLDESPSVAPNGTMVIYGTTYQGKQVLAAVSMDGRFKARLPVGQGEVKSPSWSPFL
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
B0TPX8
Q2SQW8
TSAC_HAHCH
tRNA threonylcarbamoyladenosine biosynthesis protein TsaC
Hahella
MSAWFIQKAVSVLSRGGVLAYPTEAVWGLGCDPSCEDAVNRILQLKRRPWRKGLILVSGQIEHFSQLLDRLPQQQKDQILATWPGPVTWVVPDPGVYAPLVRGAHDAIAIRVTAHPLVVELTKAFGGPIVSTSANPATREPARTLFDCRRYFKSGVDHYLPGKLSGLSKPSQIRDAATGAILRQ
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Q2SQW8
Q0BPX7
UVRC_GRABC
Excinuclease ABC subunit C
Granulibacter
MTMPDAPANPPKEADNPSLPIVEAPPGKGVTVIEAMLKLLPDRPGVYRMLDGQGEALYVGKARSLKKRVASYTQIHRLPERLRRMVSETVSMEIVTTHTEAEALLLEANLIKRLKPRFNIVLRDDKSYPWLMLTEDHAFPQIMKHRGAQTRKAASYWGPFASAWAVNQTVTAMQRIFLLRSCSDSVFANRSRPCLLFQIRRCSAPCVDRISQEDYAELVDQARAFLSGRGTEIQRDLARQMEQAAEALEFERAAAIRDRIRGLTHVQGTAVVNPASIGNADVIAVWQDAGQSCVQVFFIRGGHNNGNRAFYPAHTSAETAQDVLGAFIAQFYDDKPPPPLLLLNHTIAEQELVSEALSLKAGRRVELHVPVRGEKRAVVAHAETNAREALERKLAESAGQNRLLDGVAELFDLPTRPNRIEIYDNSHIMGTNPYGVMVVAGPEGWNKSAYRKFSIRGPITPGDDFAMMREMLERRFSRGLKERAEGPEGEANWPDLVLIDGGAGQLSAVRGILDEIGVTDVKLVAIAKGPDRDAGREWFHTEGQAPFQLPPRDPVLYYLQRLRDEAHRFAITTHRAGRSKTLVRSELDDIDGIGAARKRALLNHFGSARGVKQAGLAALEATPGISKETARRIYAHFHPGARAD
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q0BPX7
Q9LKI8
TBB_THAWE
Beta-tubulin
Conticribra
MREIVHIQGGQCGNQIGAKFWEVMSDEHGVDPTGTYHGDSDLQLERINVYFNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCMQGFQLTHSMGGGTGAGMGTLLISKIREEYPDRVMSTYSVIPSPKVSDTVVEPYNATLSVHQLVENADQCFALDNEALYDICFRTLKLTTPTYGDLNHLIAAAVCGTTCCLRFPGQLNCDLRKLAVNMVPFPRLHFFMVGYAPLTSRGSQQYRALTVPELTQQCFDAKNMMCAADPRHGRYLTCAVLFRGRMSSKEVDEQMLNVVNKSSSYFVEWIPNNVKASICDIPPKGLKMATTFVGNTTAVQETWKRVAEQFTVMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEFDEDEMEG
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9LKI8
C0QWM9
TYSY_BRAHW
Thymidylate synthase
Brachyspira
MQNYLDLLKKVLEEGEETKDRTGVGTRRIFGPQLRFKFEGNKIPIITTKRVFMKGVIIELLWFLQGSTNIKFLLENNVHIWDEWADDMGELGPVYGKQWRAWETKEGNKIDQISNIVNTLRNNPASRRIILNAWNVGEIDQMHLPPCHMMCQFSVNSKGGIITHLYQRSADLFLGVPFNISSYAILTRLLAMHSGLHASELIMTFGDAHIYNNHIEQVKLQLSREPLEQTTELFIDNRPNIFSHVYEDFKLEGYKYYPTIKAEVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
C0QWM9
D2BJS8
TATC_DEHMV
Sec-independent protein translocase protein TatC
Dehalococcoides
MSSKNETPEVEEEEPPEEAKAKGKMPIGGHFNELRQRFTRGIIALVMGVMVAFFFATPIIGFLTAPGGPDFKPAQLGVMEYASVFFNVSLWAGFIIASPYILYQLIAFITPALNRNEKKFIFIAIPAVTVMFLAGLAFAYYVALPPALNILLHWGDDVVLTVVGIKDYMNVVTRILIALGLIFETPFIIMVLARLGVVSPQWLASKRKIWVVIAFVIAALITPTFDPVNQTIMAGPLIVLYEISIWLSKLVYRKKREVSESK
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
D2BJS8
Q3KQE5
T38BA_XENLA
Transmembrane protein 38B-A
Xenopus
MESLSELSVQFSQLSMFPFFDMAHYVVSVMSAREQAGALDIAARSPMASWFSAMLYCFGGGILSSILLAEPPIAVLSNTTNIMLASTIWYMVYYFPYDLFYNCFFFLPIRLIIAGMKEVTRTWKILSGVTHAHSHYKDALLVMITIGWARGAGGGLISNFEQLVRGVWKPESNEFLKMSYPVKVTLIGAVLFTLQHGHYLPISRHNLMLIYTMFLVLIKVTMMLTHSTASPFLPLETPLQRILFGQRQKPSEVRQSASSSGAKGKPSKKTLDKDSGEQSKKKDS
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Q3KQE5
Q83II9
ULAA_SHIFL
Ascorbate-specific permease IIC component UlaA
Shigella
MEILYNIFTVFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYGINGAISDTYASMMATIDRMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTGHIMFQQAGLIAVTLFIFGYSMWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSIGHQQQFASLIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVMTIFFGAILLSFGIDTVQAMAGKVHWTVYILQTGFSFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPMFFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWVVKLTGMSAWMGMADWSILAPPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Q83II9
A0L833
TATC_MAGMM
Sec-independent protein translocase protein TatC
Magnetococcus
MNLDVEQKAPLVEHLIELRNRLMISVGAIIVGFILCYSFSEQIFEFLAAPLHEILGPQAKMIYTALHEAFFTQIKVSFFAGLFLAMPVLFTQMWLFIAPGLYQHERSAILPFLFVTPVLFFMGGTLAYYFVFPLAFKFFLGFQSSTIEALPSMREYLSLVIKLIIAFGITFELPVGLLLAIKAGVVSTAGLVDKRKYNIVLAFVAAAILTPPDPFTQVMLAIPIMLMYEISIFFGRGIERKRAEQEAAEEAQWAADHNVDDDDVDHPEHKA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
A0L833
Q11HD9
TRMFO_CHESB
Folate-dependent tRNA(M-5-U54)-methyltransferase
unclassified Chelativorans
MTTKPIHVIGGGLAGSEAAWQAAEAGVPVILHEMRPVRGTDAHKTDGLAELVCSNSFRSDDAQTNAVGLLHAEMRLAGSLIMRAGDANQVPAGGALAVDRDGFSDAVTQAIHGHPLITVVREEVAGLPPSEWDQTIIATGPLTAPSLAEAIRQETGAEALAFFDAIAPIVHFDTIDMDTCWFQSRYDKAGPGGTGKDYINCPMNKEQYQAFVQALLDGEKTAFKEWEGTPYFDGCLPIEVMAERGPETLRHGPMKPMGLTNAHKPDEKAYAVVQLRQDNALGTLYNMVGFQTKLKYAEQVRIFRMIPGLENAEFARLGGLHRNTYINSPALLDITLQLKSRPGLRFAGQITGCEGYVESAAMGLMAGRFAAAARLGRKMMPPPATTAFGSLISHITGGHILSEDEPGKRSFQPMNVNFGLFPPVELPKPEGKRLRGKEKTLAKKRAITARALADCSDWLGVPTRAAAE
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
Q11HD9
Q9XYU2
TCTP_PLAYO
Translationally-controlled tumor protein homolog
Plasmodium (Vinckeia)
MKVYKDIFTNDEVCSDSYIQEDPFGNPEFREIAFEVKSNKRIKGNDDYGIADNSEDAVDGMGADVEHVIDIVDSFQLTSTSLSKKEYSAYVKNFMQRILKHLEEKKPDRVDIFKTKAQPLIKHILTNFDDFEFYMGESLDMEAGLIYSYYKGEEITPRFVYISDGLFEEKY
Involved in calcium binding and microtubule stabilization.
Q9XYU2
P85109
VSP1_GLOBR
Snake venom serine protease
Gloydius
VIGGDECNINEHRFLVALYHSRSRTFLCGGTLINQEWVLTAAHCDRFFMYIRLGMHNKNVNFDDEQRRSPKEKYFFRCSNNFTKWDKDIMLIRLDSPVNNSAHIAPLSLPSNPPSVGSVCRVMGWGQTTSPQEDLSDVPRCANINLFNFTVCRAAYPWLPATSRVLCAGDMEGGIDTCNRDSGGPLICNGQFQGIVSKGQNLCAQPRKPALYTKVFDHLDWIQSIIAGNKTVTCPP
Thrombin-like snake venom serine protease. Cleaves bonds after Arg and Lys, converts fibrinogen (FGA and FGB) to fibrin and releases both fibrinopeptides A and B, and fibrinogen peptide Bbeta1-42. Has a blood clotting activity.
P85109
Q8XXY2
TRPA_RALSO
Tryptophan synthase alpha chain
Ralstonia
MSRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMADGPVIQRASERALAKKIGLRTVLDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTEARMAQIARVASGYIYYVSLKGVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLLEEASREQAVQCLTDFIADIRQALDA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Q8XXY2
A7NI03
TPIS_ROSCS
Triose-phosphate isomerase
Roseiflexus
MRTPLLAGNWKMYKTTGEARELVEGLLHGLGDVGDRKVLVCPPFTALQTVHDLVQGTPIALGAQDVYIEPQGAFTGAISPVMLRDLGCAYVIVGHSERRAIFGEGDELIGKKVRAALAHDLTPILCVGETKPQRDAGHAETVVVAQVRAALTGMTPEQIGRIVIAYEPVWAIGTGDTATPADAQAMHETIRRILGDMAGSDTAATINILYGGSVKPDNIDDLMAQPDIDGALVGGASLKADSFLRIVHFLSPQE
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
A7NI03
Q3YS67
TSAD_EHRCJ
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Ehrlichia
MKKSVKVVLGIETSCDETAVAIVNSNKEVLSHKILSQKEHAEYGGVVPEIASRAHINYLYDLTVSCIEESQLSLNNIDAVAVTSGPGLIGGLIVGVMIAKGIASVTGKPIIEINHLEAHALIVRMFYEINFPFLLLIISGGHCQFLIVYNVGCYHKLGSSLDDSLGEVFDKVAKMLNLGYPGGPVIEKKSLSGDSKSFVLPRALTGRCGCDFSFSGLKTAVRNIIMNHEYIDNKLICDISASFQECVGDILVNRINNAIAMSKAIDKRIDKLVVTGGVAANKLLRERMLRCASDNNFEIFYPPSKLCTDNGIMIGWAGIENLVKDYVSNLDFAPKARWPLESLRSNIMKE
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q3YS67
Q06493
YLH47_YEAST
LETM1 homolog
Saccharomyces
MLKYRSLPIKRAIHHPAPGITPISPRIMVSRLRVIPSFNLKFNRWNSSVPESSKKELKTTDGNQESASKVSPVKEKEKVPFKVKMQKALRHYWDGSKLLGLEIKISSKLLMKSAAGYPLTRRENLQLKRTTQDIVRLVPFAAFLIIPFAELLLPFALKLFPNLLPSTYESSKKRENKLENLRNTRKLMSEIIKNNKSHFKPNNISEEQKALFNRFYTHVRATGVPESRQQLIEVARLFTDDTVLDNVTRPYLIALAKYMNLQPFGTDVMLRYRIRYKMLELKKDDLSIYYEDAEQLSLSELKTACASRGIRSVDVEPSVLYSNLRLWLNMRLKDKIPSTLLIMATAYNYGNVQSKESLYDALCDVLIGIPDELYHEVKVNVVKEDEASAKQKLKQLREQEEIMKEEEQQEENAIVSVKDELSLDDQDKNIDAAAPDVKPHDTKPIGEAAAIKEK
Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation.
Q06493
Q39QN3
UVRC_GEOMG
Excinuclease ABC subunit C
Geobacter
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARVAEVEVIVTDTEKEALILENTLIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVRQDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRRRRPCLFYQLRQCSAPCHGLISPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQKMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYSREVFIPDEVLVPLPVADSAALAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALREKQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTYPVGSRVSFRDGKADKGGYRHYRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDVDAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAITYHQKLRGKDTIRSILDTIPGIGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAESIWKSLHENDEGDTP
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q39QN3
B3DRW0
TPIS_BIFLD
Triose-phosphate isomerase
Bifidobacterium
MASKRIPLVAGNWKMNFDHLEATYFVQKLVWLLRDAHFDFKRCEVALFPSFTSLRSVQVLVEADKLHVAYGAQSVSVTTQGAFTGDVSADMIAHLGCSYVIVGHSERRKYHPEDDANIVDQVRAVLAAGMQPILCVGESFEERRQGIELDFAVGQVRDVTRDLNEEQAAKLIVAYEPVWAIGTGMVATPQSAQDAANAIRNDLKTTFGTKVSDSVRILYGGSVTSKNAAELISQPDVDGFLIGGAALDVEELAKIARLALKSTKSRN
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
B3DRW0
O43033
YGU4_SCHPO
Uncharacterized methyltransferase C3B9.04, mitochondrial
Schizosaccharomyces
MGILKKTIFIGGIYGLGVYIGAVAWRLRKDVLNYESRQKSDLLIPNSNSISIYNQIADKYSRKITREEIFSGIYFLRYFLLRNAKGDVLEVGSGPGTNFPFYKWKKINTLTLVEPAEKMREIADARAKKKVPPNVLYRQFADLRQLPPNQSYDTIIQTFCICSQEKAVEQLNNYRSLLRSDGRILLIEHGKGKYKFLNRILNAYAESHYESWGCVWNRDIEQLLEDSELTIDSCKRFNFGTTYVIEAH
Probable methyltransferase.
O43033
Q73S79
Y4197_MYCPA
Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4197c
Mycobacterium avium complex (MAC)
MTRTDQDSWDLASSVGATATMVAAARALASTGERPIINDPFAAPLVRAVGLDFFRRLVDGEVAPADPQRGERDLQLETDSIAVRTRFFDDFFTGAARDGIRQSVILAAGLDARAYRLDWPAGAVVYEVDQPKVVEFKTNTMAALDARPAAQLRTVSIDLREDWPEALRANGFDVTQPTSWSAEGLLMYLPPEAQDRLFDNITALSAPGSRLATEYHPDATGTTMAQRAQEFNDRWARVGCDIDLSGLFFDGERSNVVEYLTGRGWRVSARPRRDLFDDYGLAYPEDDETAQFPNIVAVSAELG
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Q73S79
Q7N9T4
YIHI_PHOLL
Der GTPase-activating protein YihI
Photorhabdus
MNPLKKKAPAKVSASKQKRKNREELNAEGRARKREKKHRGNPPGNRNQEQSGDKHPSGKQQRDPRLGSKVPVPLIVGEQPTKPVVANKVETKPRLSPQEELAMLENDDRLDALLERLENGESLSKEEHAYVDTTLDRIDALMEELGIKLDEEEREEEKQDDIMQLLKGN
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
Q7N9T4
Q9PJS0
YIDD_CHLMU
Putative membrane protein insertion efficiency factor
Chlamydia
MKTSWIKIFFQGMIHLYRWTISPLLGSPCRFFPSCSEYALVALKKHPLKRSLFLIANRLLKCGPWHIGGIDLVPGTSIEEYLESPDDKNVPPDQETV
Could be involved in insertion of integral membrane proteins into the membrane.
Q9PJS0
Q2NL26
TKTL1_BOVIN
Transketolase 2
Bos
MADAEASATMADEAKPDSKTLQILRDMANRLRIHSIRATCASSSGHPISCSSAAEIMSVLFFHVMRYKQADPKNPDNDRFILSKRLSFVDVATGWLGQGLGAACGMAYTGKYFDKASYRVFCLVGDVESWEGSVWEALAFASHYSLDNLVAIFDVNRLTHSTTLPLEHSIDVYQKRCEAFGWNTLVVDGRDVEALCQVFWQAAQMKNKPTAVVAKTFKGRGIPSVEDAENWHGKPMPKERADAIIKLIESQIETNKSLEPKAPIEDSPQINISVIEMTSPPDYEISDVIATRKACGLALAKLGHANDRVIVLDGDTKNSTFSDIFKREHPERFIECFIAEQNMVSVALGCVTRGRTVAFACTFAAFLTRAFDQIRMGGISQTNINLIGSHCGVSIGEDGPSQMALEDLAMFRAIPNCTIFYPSDAISTEHAVFLAANIKGMCYIRTSRPETAIIYTPQESFEIGQAKVIRQSVNDKITVVGAGITLHEALAAADDLSKQGISLRVIDLFTVKPLDAATIISNAKATGGQIITVEDHYPEGGIGEAVSAAVSMEPDIVVHHLAVSGIPRSGKPSDLLDMFGISSKHIIWAVERILMK
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Q2NL26
B1VSW9
UREG2_STRGG
Urease accessory protein UreG 2
Streptomyces
MRHGHPPTDIHHGINQGEPMDDNVLRVGIGGPVGSGKTALIEALVPVLIERGHRPAVITNDIYTQEDAQHVRRTLAGVLEPERVVGVETGACPHTAVRDDPTMNLAAGAEMLERFPDTDTLLYESGGDNLTLTFSPALVDLFLFVLDTAEGEKMPRKRGPGITESDLLVINKIDIAQYVRTDIGIMEADAHRVRDDRPVVLTDCLTGVGIDDIALYLESRRKVLI
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
B1VSW9
Q495A1
TIGIT_HUMAN
V-set and transmembrane domain-containing protein 3
Homo
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Q495A1
B5ZAX5
Y158_UREU1
UPF0122 protein UUR10_0158
Ureaplasma
MLNKNKRWYLIALYDIYQGLLTTKQCEYFNLHYFKDLSFSEIAELKEVSKSAISDCLNKVCDQLLKYEQALLIYEKNKKRNDLYTLINDSELVKKLKDI
Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
B5ZAX5
Q6FQJ1
VPS27_CANGA
Vacuolar protein sorting-associated protein 27
Nakaseomyces/Candida clade
MATTSSEEFSEVIERATSESIPNGELNLPVALEISDILRSRRIAPKDGMRCLKKRITNTTNNPNTQLSSWKLVEICIKNGGIPFLREICSREFMDTMEHTILKYDDSDEVVELVTTMLYELYLAFQNDSQLNYVSRVYDKLRQRGVKFPEGAPISSNVNALFDSKTPADWIDSDACMICSKKFSLLNRRHHCRSCGGVFCQDHSSKSIPLPDLGIYDSVRVCDNCYDDYDYKKGSGSQGKKRKHRKSHRHATEDEDEDLRKAIELSLRASNSSVEPVIPVVESEPQIPAVEEEDPDLKAAIEASLREAEEEKRRREEHAQQQNTNAYPQQFRPPANELTPADEEDIYLFASLVERMKTRPPSEILDDPQLQQLAQKVFASKPRLGNTLNSKIQKYNTLVDMNGKISHIMNTYDNLLEQELRNINLSERFNVPQAQADPYSQYSQYNQPAIQNNTSQTNNVVNNKPLSQRESEPQYTAPTDSQTIESKAYERQLENLVQPPSNVNNERVASEPPYPNEELNDITSIQLNSERAGKYEENAVPPGSIPYPIENDDQDETTRTKKNDNITNFDFPTVPARKLPENNVEQVEDKPQDSQEEALLIEL
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Q6FQJ1
Q55GQ6
UPP_DICDI
UMP pyrophosphorylase
Dictyostelium
MSYPENVVVLKSNHQLKGLFTIIRNRETKREDFIFYSDRIIRLLIEEGLYCLPFHETTITTPTGCEYQGVTFASKICGVSIVRAGESMEAGLRAVCKHIKIGKILIQRDEETALPKLLYAKLPHDIANRQVLLLDPMLATGGTVTQAVEVLLERGVKEENIVFINLVASPEGIKVFTDKYPRVKVVTGEIDSHLNEKKYIIPGLGDFGNLYFGTED
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Q55GQ6
P84035
VM3BA_BOTAS
Snake venom metalloproteinase basparin-A
Bothrops
SHDNAQLLTAIKAYIATMCDPKMAVIMAHEIGHGGYYGYCRKIPCAPEDVKDDDIGMVLPGTK
Snake venom zinc metalloproteinase that catalyzes the conversion of prothrombin (F2) to alpha-thrombin through formation of a thrombin intermediate, without requiring additional cofactors. Also inhibits collagen-dependent platelet aggregation in vitro, an effect that does not depend on proteolytic activity. In vivo, at low doses, induces defibrin(ogen)ation when injected intravenously or intramuscularly into mice. At higher doses, causes sudden death by intravenous administration due to numerous occluding thrombi in pulmonary vessels.
P84035
A3QD46
TOLB_SHELP
Tol-Pal system protein TolB
Shewanella
MKNLGRWLILGLAFLTIPAKAALDIVITEGVDAARPIAVVPFVWQGSTPMPQQISDVVMSDLTRSGTFKPMDELGLPQRNLGSLAQMDLKAWSNVAAEAVVMGTVKPYGPDQYLVNFELIDLVKAQMQSGGPQSASEYLLDSRETVISSAQFRQYGHRISDIVYEKLTGIRGAFLTRIAYVVVDHKAKSPYKLMIADYDGYNEQMLLRSPEPLMSPAWSPDGRRLAYVSFENKQAEVFVQDIYTQQRTKVTSFPGINGAPTFSPDGKKLALTLSKDGQPEIYVADIATKAIKRVTNHYAIDTEASWTPDGKSLIFTSERGGRPQIYQVALASGKVTRLTFEGEWNLGGSISPDGRSMVFVNRTNGKFNIARMDLETRFMQVLTTTRLDESPSIAPNGTMVIYGTTYQGQQVLAAVSMDGRFKARLPVGQGEVKSPAWSPFL
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
A3QD46
B4RY55
UBID_ALTMD
Polyprenyl p-hydroxybenzoate decarboxylase
Alteromonas
MKYKDLRDFIRQLEAKGELVRISQPIDTDLEMTEIADRTLRAGGPALLFENPKNHDMPVLANLFGTPERVAMGMGQESVEALREVGKLLAYLKEPEPPKGLKDLWEKLPVFKQVLNMPAKVLKKAPCQEVVLTGDDVDLSKIPVQRCWPGDAAPLVTWGLSVTKGPHKKRQNLGIYRQQVIGKNKLIMRWLSHRGGALDFREWCQTHPGEPYPVSVALGADPATILGAVTPVPDTLSEYAFAGLLRGDKTEVVKSISNDLQVPASAEIVLEGYIAQDETAPEGPYGDHTGYYNEVDDFPVFTVTHITHRKDPIYHSTYTGRPPDEPAILGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVMIENTPIDYLDFASPVSGLGSKMGMDATNKMPGETDREWGVPIVMDEGVKKRVDDIWDSLGIM
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
B4RY55
Q7CRQ0
URODH_AGRFC
Hexuronate dehydrogenase
Agrobacterium tumefaciens complex
MKRLLVTGAAGQLGRVMRERLAPMAEILRLADLSPLDPAGPNEECVQCDLADANAVNAMVAGCDGIVHLGGISVEKPFEQILQGNIIGLYNLYEAARAHGQPRIVFASSNHTIGYYPQTERLGPDVPARPDGLYGVSKCFGENLARMYFDKFGQETALVRIGSCTPEPNNYRMLSTWFSHDDFVSLIEAVFRAPVLGCPVVWGASANDAGWWDNSHLGFLGWKPKDNAEAFRRHITETTPPPDPNDALVRFQGGTFVDNPIFKQS
Catalyzes the oxidation of D-galacturonate and D-glucuronate to galactarate and D-glucarate, respectively. In fact, in water solution the substrate D-galacturonate is predominantly in pyranosic form whose beta anomer is converted by the enzyme to D-galactaro-1,5-lactone; in solution, this reaction product rearranges to the more stable D-galactaro-1,4-lactone. Makes part of the oxidative degradation pathway of D-galacturonate, which allows A.tumefaciens to utilize D-galacturonate as a sole carbon source. Cannot use NADP(+) instead of NAD(+) as cosubstrate. Is not active on D-galactose, D-glucose, D-galactonate and D-gluconate.
Q7CRQ0
Q6PVW7
ZPBP2_CHICK
Zona pellucida-binding protein 2
Gallus
MAGGGGRPCSPQRALLGMVAIMAVVAEARWGAPGRARAAPEEDQISVGFFRKNVIYGNVRRAENVYVKMFTNSPSLVCMDLSLSQEEIIDPKYSWTGPDGRNLEGRGYANLTGSGELMLVGFQESMSGAYTCTLSHRIIETSAQEEVDVRDTYRFMVYAYREANHVYQVSVRFTAKGCELAANARFVEELKKIMESLISDLTCGVKGPSYRCHSLEAPHRGSPSELFITFQVNPFAPGWEDLCSRLPQDCEDTTNRRAQEATERIGEFFRKQTYALKHQFQTVPTIHYVEGSFSVTPIDSCRPGFGRNNITHRSCAGCCVVCSPGTYSPDSAGSCRVCAGRRTAGYGAKSCP
May be implicated in the gamete interaction during fertilization.
Q6PVW7
P04185
UROK_PIG
Urokinase-type plasminogen activator chain B
Sus
MRVLRACLSLCVLVVSDSKGSHELHQESGASNCGCLNGGKCVSYKYFSNIQRCSCPKKFQGEHCEIDTSQTCFEGNGHSYRGKANTNTGGRPCLPWNSATVLLNTYHAHRPDALQLGLGKHNYCRNPDNQRRPWCYVQVGLKQLVQECMVPNCSGGESHRPAYDGKNPFSTPEKVEFQCGQKALRPRFKIVGGKSTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVVSATHCFINYQQKEDYIVYLGRQTLHSSTHGEMKFEVEKLILHEDYSADSLAHHNDIALLKIRTDKGQCAQPSRSIQTICLPPVNGDAHFGASCEIVGFGKEDPSDYLYPEQLKMTVVKLVSHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSTQGRLTLTGIVSWGRECAMKDKPGVYTRVSRFLTWIHTHVGGENGLAH
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
P04185
Q6G5P5
TILS_BARHE
tRNA(Ile)-lysidine synthetase
Bartonella
MCVRLAGNLFKTSDFIQCQKLILAVSGGSDSLALLFLVKDHLKTLSVPPEIIVVTVDHQLRQESAREASIVAEICRAHHIQHRIVRWEGKKPKTHIASSARVARYDLLFQEAQKQGATLIMTGHTLNDQVETYQMRYQRLQKSADVLQQEAFAEMGGGVHADVLQQEAFAERCERMGVGGHGGDIAEKSDGLIYERGLSCIPREALLRGTVRLIRPLLGVKRETLRTYLRLKEKTWIEDPTNEDCNFERVRVRQSLQPKKFTCIARKVHEAALQRRQQAKNIADLILALDITVEYGRCFIAKPALFLQKHPGFPFVVGLFAVLMGGGFYLLPHKKLSTLVQKLSLHSSEKRRFTYAGSVIEYNRSGIAFWREARNIKEAIVEKGQTFLWDGRYQITNHSHEPIKVGAAGLQQLKSLFKNNNFNLENTHFPSLKSLLMISNDKGYDIPELAYHAAMQHTITIRRIMAPFDWLLSSQDAAFVNVVQPFFDIKVKG
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Q6G5P5
Q8T3S6
TXAA2_ARAVE
Toxin 2
Araneus
MALALLGLTIKPEHVPEGTGKAVADVEALACDPAQCMRSCPFNPFLNQYGGICKNGQCVCVKPS
Putative insecticidal toxin.
Q8T3S6
Q820E4
TRMD_CHLCV
tRNA [GM37] methyltransferase
Chlamydia
MEIEILSLFPDYFDSPLRSSILGKAIKNGLLKIQSRDIRDFGLGKWKQVDDAPFNNDGMLLMAEPVVQAIRHIKRSDSRVIHLSPQGKPLTAQKSRELAKCSHLIFLCGHYEGIDERALESEVDEEISIGDYVLTNGGIAALVVIDALSRFIPGVLGNQESAEKDSLENGLLEGPQYTRPRVFEGKEVPEVLLQGDHQAVARWRKQVSLDRTRERRPDLYIRYLYDRENEEVFPREEDTKQSTLEGESAVVLEVEDLQRSRKFYSKMFRLNQPSKDKLQIPGRTQMVLHLQEVGLKNKNTAILSLRLDCEDDFFSFLGRWKMLGGTLEQADDHGTVRLVRDFDGHQWTISYKKVK
Specifically methylates guanosine-37 in various tRNAs.
Q820E4
Q0DKN3
VLN1_ORYSJ
Villin-1
Oryza sativa
MKGVDDAFLGVGDKPGLDIWCIMGSNLIAIEKSLHGKFYTGNTYIILSTVELKSGVRQHNVHYWVGEEAKEEDCLTASDKAIELDVALGSNTVQYRETQGEESDKFLSYFKPCIIPIQGSLSSHMRIYGDKSKDTTMFRCEGEHVARVTEVPFSRSSLDHKAVFVVDTESKIFLFSGCNSSMQTRAKALDVVKHLKENRHCGRCEIATIEDGKLVGDSDAGDFWNLFGGYAPIPRDVQDTVMTELMTTSSKKLFWINKRNLVPVETNLLEREMLNSDRNYILDCGTEVFLWMGMTTLVSERRTSVTALEDYVRCEGRQSNARSVILTEGHETVEFKMHFQHWPKNAVPKLYEAGREKVAAIFKHQGYDVTEIPEDKPRHFISCNGSLKVWLVDNGSVTLLCTEEQEQLYNGDCYIIRYSYIEDGKDYHLFFAWSGLNSINEDRVAAASLMSGMIDSVKGHAVVAQVFEGREPEMFFLVFKSLIIFKGGRSMAYKNFVSQRSDANGWYQKNGVALFRVQGLKHDCIRAIQVDLAASSLNSSHCYILQAGGSFFTWLGSLSSPSDHNLLDRMMDKLCPLKQSLLVREGSEPDRFWEALGGRSEYLREKQVKDWPADPHLYTCHFEQGLFKAKEVFSFSQDDLVTEEILILDCVEELHIWVGHQSGVLSKEQALDIGKMFLQAGIHQDGRRPIDTTMYIVTEGDEPRFFTSFFNWDYSKQTMLGNSFERKLAILKGISQKLETPERSLRKSSSSSLPRRSPGTSSSEPTTPEQRAAARTFASASTGKLLRERSPAALSPSLSTPSPSPRSRSSASSSPASWNSTPSTVARRLFPPSLHASAEAVATGTPRRR
Ca(2+)-independent actin-binding protein. Binds actin microfilaments (MFs). Involved in actin filament bundling, severing and capping. Caps the barbed end of actin filaments and protects them from disassembly. Promotes VLN3-mediated MF severing.
Q0DKN3
P24055
TF_RABIT
Coagulation factor III
Oryctolagus
MAPPTRLQVPRPGTAVPYTVLLGWLLAQVARAADTTGRAYNLTWKSTNFKTILEWEPKSIDHVYTVQISTRLENWKSKCFLTAETECDLTDEVVKDVGQTYMARVLSYPARNGNTTGFPEEPPFRNSPEFTPYLDTNLGQPTIQSFEQVGTKLNVTVQDARTLVRRNGTFLSLRAVFGKDLNYTLYYWRASSTGKKTATTNTNEFLIDVDKGENYCFSVQAVIPSRKRKQRSPESLTECTSREQGRAREMFFIIGAVVVVALLIIVLSVTVYKCRKARAGPSGKESSPLNIA
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
P24055
Q7VFX7
UVRB_HELHP
Excinuclease ABC subunit B
Helicobacter
MGKFILDSQFAPAGDQPQAIQKITQFIHNGAQYSTLVGVTGSGKTYTMANIIANLNIPTLIMTHNKTLAAQLYSEFRGFFPKNHVEYFISHFDYYQPEAYIPRRDLFIEKDSSINEDLERLRLSATTSLLAYDDIIVIASVSANYGLGNPAEYLTMIHKFEIGQEEAQKTLLLKLVDMGYTRNDTIFERGNFRVNGEVIDIFPAYNEKEFIRIEFFGDEIERIGVFDALERTALTQLESFVLYAANQFIVGAQRLQSAIKNIEVELENRLEEFVSQDKQIEYQRLKTRTEFDLEMIKESGICKGIENYARHLTGKKAGETPYSLLDYFEQKGKPYLLIVDESHVSLPQFGGMYAGDRSRKEVLVEYGFRLPSALDNRPLRFDEFINKAPHFLFVSATPAQKELELSQEHIAEQIIRPTGLLDPLYEVRDADNAVLDLYDEIKARIAKNQRVLITTLTKKMAEELSKYYAELGIKVRYMHSDIDAIERNHLIRALRLGEFDVLIGINLLREGLDLPEVSLIAIMDADKEGFLRSETSLIQTMGRAARNVEGKVILYAKKITGSMQRAFEVTDYRRTKQEEFNRIHNITPKSVQRNVEQELKIESSGLSRLYEKASKKIPKSERESIIKELNIKMHQAAKALEFEEAARLRDEIARIRTM
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q7VFX7
A5D3C3
YQGF_PELTS
Putative pre-16S rRNA nuclease
Pelotomaculum
MRIMGLDLGDKKIGVALSDPMGWTAQGLDVIAVKGPPEASVERISELVRQYGVGKIVVGLPRNMNGSFGPRAERARAFAGCLAGALNLPVELWDERMTTLEAEKLLIEADLSRARRRQVIDKMAAVLILQSFLDSQGRPRREAGGKNPGGPEEP
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
A5D3C3