accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
B7LWL0
TRUD_ESCF3
tRNA-uridine isomerase D
Escherichia
MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWFCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLRDVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAEETELQTLLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGEYAHIAE
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
B7LWL0
Q9ZJG8
YIDC_HELPJ
Membrane protein YidC
Helicobacter
MDKNNNNNLRLILAIALSFLFIALYSYFFQEPNKTTTETTKQETTNNHTATSPTASNTITQDFSVTQTIPQESLLSTISFEHAKIEIDSLGRIKQVYLKDKKYLTPKEKGFLEHVSHLFSSKENSQPSLKELPLLAADKLKPLEVRFLDPTLNNKAFNTPYSASKTTLGPNEQLVLTQDLGTLSIIKTLTFYDDLHYDLKIAFKSPNNLIPSYVITNGYRPVADLDSYTFSGVLLENTDKKIEKIEDKDAKEIKRFSNTLFLSSVDRYFTTLLFTKDPQGFEALIDSEIGTKNPLGFISLKNEANLHGYIGPKDYRSLKAISPMLTDVIEYGLITFFAKGVFVLLDYLYQFVGNWGWAIILLTIIVRIILYPLSYKGMVSMQKLKELAPKMKELQEKYKGEPQKLQAHMMQLYKKHGANPLGGCLPLILQIPVFFAIYRVLYNAVELKSSEWVLWIHDLSIMDPYFILPLLMGASMYWHQSVTPNTMTDPMQAKIFKLLPLLFTIFLITFPAGLVLYWTTHNILSVLQQLIINKVLENKKRAHAQNIKE
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Q9ZJG8
P77315
YPHD_ECOLI
Probable ABC transporter permease protein YphD
Escherichia
MSASSLPLPQGKSVSLKQFVSRHINEIGLLVVIAILYLVFSLNAPGFISLNNQMNVLRDAATIGIAAWAMTLIIISGEIDVSVGPMVAFVSVCLAFLLQFEVPLAVACLLVLLLGALMGTLAGVLRGVFNVPSFVATLGLWSALRGMGLFMTNALPVPIDENEVLDWLGGQFLGVPVSALIMIVLFALFVFISRKTAFGRSVFAVGGNATAAQLCGINVRRVRILIFTLSGLLAAVTGILLAARLGSGNAGAANGLEFDVIAAVVVGGTALSGGRGSLFGTLLGVLVITLIGNGLVLLGINSFFQQVVRGVIIVVAVLANILLTQRSSKAKR
Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane.
P77315
Q20745
UNC84_CAEEL
Uncoordinated protein 84
Caenorhabditis
MAPATEADNNFDTHEWKSEFASTRSGRNSPNIFAKVRRKLLLTPPVRNARSPRLTEEELDALTGDLPYATNYTYAYSKIYDPSLPDHWEVPNLGGTTSGSLSEQEHWSAASLSRQLLYILRFPVYLVLHVITYILEAFYHVIKITSFTIWDYLLYLVKLAKTRYYAYQDHRRRTALIRNRQEPFSTKAARSIRRFFEILVYVVLTPYRMLTRSNNGVEQYQYRSIKDQLENERASRMTTRSQTLERSRKFDGLSKSPARRAAPAFVKTSTITRITAKVFSSSPFGEGTSENITPTVVTTRTVKQRSVTPRFRQTRATREAITRALDTPELEIDTPLSTYGLRSRGLSHLNTPEPTFDIGHAAATSTPLFPQETYNYQYEEATGNKIKTAFTWLGYLILFPFFAARHVWYTFYDYGKSAYMKLTNYQQAPMETIHVRDINEPAPSSSDVHDAVGVSWRIRIADFLSSFVATIVEAHQVVFAMFKGGIVETVSYFGGLFAGLTDKKSSKFSWCQILGLLLALLFAIFLLGFLTSDNTAIRVKEITKDKNASKKSEGSLPAVPIWISAANHVKHYTWMVKEFVVDIAFDTYNYGKSTIGRLGTTPRYAWDLIASGCGAVGNGLKSVLSSSFRFIDFCAGKLFYYGSDGFLSANKSIGTFFNGCYETLYNGCTAIVGHTKSFIYNASNAVYNFFSTIFAGLLNFSTSSQNSILSLLKSFGTGITNIFYNFIYAPIAGVFNFAGDNYMYFFNEVAAVFGKVYNSVVSVLKTVINWILFLIAYPFSLCTRAWIRISQYAPEDVVQVIPIPQAITPTPDVERIVEEPLRKVTDVEDEELVIIPAPAPKPIPVPAPTPAPVIIHQTNVVETVDKDAIIKEVTEKLRAELSAQFQQELSAKFEQNYNTIIEQLKMENTNIQYDKNHLEAIIRQMIYEYDTDKTGKVDYALESSGGAVVSTRCSETYKSYTRLEKFWDIPIYYFHYSPRVVIQRNSKSLFPGECWCFKESRGYIAVELSHFIDVSSISYEHIGSEVAPEGNRSSAPKGVLVWAYKQIDDLNSRVLIGDYTYDLDGPPLQFFLAKHKPDFPVKFVELEVTSNYGAPFTCLYRLRVHGKVVQV
Involved in nuclear migration and anchoring in hypodermal precursor cells . Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton . Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules . Its role in nuclear migration may be in association with lamin, lmn-1 . Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization . Not required for centrosome attachment to the nucleus . Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells . May be involved in DNA damage repair through an association with zyg-12 . Potentially has roles in homologous recombination, double strand break repair and meiotic recombination . Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links .
Q20745
Q7TTX7
TGT_PARMW
tRNA-guanine transglycosylase
Parasynechococcus marenigrum
MFGFEISAHCANTAARCGCFHTPHGPVHTPRFMPVGTLATVKGISTDQLARTGAQMVLSNTYHLHLQPGEEIVAAAGGLHGFMGWDGPMLTDSGGFQVFSLGDLNKIDDRGVVFRNPRDGRIIDMTPEHATQIQMALGADVAMAFDQCPPYPATENDVIDACRRTHAWLARCVEAHSRDNQALFGIVQGGCFPHLRRESARAVADFDLPGIAVGGVSVGEPVEEMHRIVRDVTPLLPTHKPRYLMGIGTLREMAVAVANGIDLFDCVLPTRLGRHGTALVGGERWNLRNARFRHDHTPLDPSCPCPTCSGGHTRAYLNHLIRSEELLGLTLLSLHNITHLLRFTTAMSQAIRDGCFSEDFAPWEPDSPAHHTW
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q7TTX7
A7Z0S0
TRUA_BACVZ
tRNA-uridine isomerase I
Bacillus amyloliquefaciens group
MRVKCTIAYDGHLFNGYQVQPGKRTVQSELEKALAVIHKTDGRVPVYSSGRTDSDVHAAGQVIHFDTPLSIPGEKWPFALNALLPDDIAVKTAEIADDGFHARFSAVQKEYRYFVYTEKHPDVFKRHYAYHFAYPLNVQKMREASRHLVGTHDFTSFCAADTAVQDKVRTIYELDWTETVDGLQMRITGNGFLYNMVRIIAGTLLDTGAGKFSPDDVKAMLEAKDREAAGRTAPGHGLYLWSVCYDN
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
A7Z0S0
Q9A6H0
TYSY_CAUVC
Thymidylate synthase
Caulobacter
MSTAVLDAPKAATDHPERQYLTLLADILENGVQRGDRTGTGTLGVFGRQIRFDLAKGFPVLTTKKLHLRSIIIELLWFLKGDTNIAYLKDNGVRIWDEWADENGDLGPVYGKQWRSWATPDGRVIDQISALVENLKANPNSRRHIVTAWNPADVDDMALPPCHCLFQFFVADGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAKVVGLEPGEFVHTFGDAHLYLNHLDQAREQLTREPFDFPTMKIADKRDLFGFEYEDFTLEGYQAHPHIKAEVSV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q9A6H0
P23669
THRC_CORGL
Threonine synthase
Corynebacterium
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYYVSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIANTSVK
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
P23669
P38987
TEM1_YEAST
Protein TEM1
Saccharomyces
MATPSTGANNSIPAVRNQVEVQVGLVGDAQVGKTSLMVKYVQNIYDKEYTQTLGVNFLKRKVSIRSTDIIFSIMDLGGQREFINMLPIATVGSSVIIFLFDLTRPETLSSIKEWYRQAYGLNDSAIPILVGTKYDLLIDLDPEYQEQISRTSMKYAQVMNAPLIFCSTAKSINIQKIFKIALAKIFNLTLTIPEINEIGDPLLIYKHLGGQQHRHHNKSQDRKSHNIRKPSSSPSSKAPSPGVNT
GTP-binding protein involved in termination of M phase. May play a role in triggering the degradation of G2 cyclin to inactivate M-phase promoting factor at the termination of mitosis. Acts upstream of CDC15 kinase and may be required to activate the CDC15 protein kinase pathway.
P38987
Q7WY78
TAGT_BACSU
Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagT
Bacillus
MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLNNASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLVTFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVVESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRTRKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFPFITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV
May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
Q7WY78
A7LAC6
VSP1_TRIAB
Snake venom serine protease
Trimeresurus
MVLITVLANLLILQLSYAQKSSELVIGGDECNINEHRFLVALYDVWSGDFLCGGTLINKEYVLTAAHCETRNMYIYLGMHNKNVQFDDEQRRYPKKKYFFRCSNNFTRWDKDIMLIRLNRPVRNSEHIAPLSLPSSPPSVGSVCRVMGWGTITSPNETLPDVPRCANINLLNYTVCRGVFPRLPARSRTLCAGVLQGGIDTCKRDSGGPLICNGQLQGVVFWGPKPCAQPRKPALYTKVFNHLDWIQSIIAGNTTVTCPP
Thrombin-like snake venom serine protease.
A7LAC6
Q8ZK90
ULAA_SALTY
Ascorbate-specific permease IIC component UlaA
Salmonella
MEILYNIFTIFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYGINGAISDTYASMMATIERMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTGHIMFQQAGLIAVSFYIFGYSMWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSIGHQQQFASWIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVMTIFFGAILLSFGIDTVQAMAGKTHWTIYILQTGFSFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPMFFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMADWSILAPPMMQGFFSLGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Q8ZK90
O14273
YET4_SCHPO
Meiotically up-regulated protein C8C9.04
Schizosaccharomyces
MTTNPDIVKQTKNEIHQVTSRVQEKLDSKSTNAVEQNNNSSQASVTKDNKKKAAKRAKKKAAKKKKQSAAASASSTPVEEAQHAQEEQQEQTILQEPGFTQTIVEKDADQVDEPLEPIASSALGTVEPPTDNKPSASTSTAVPTTEARNTSITEPANSPSSSSSSASTKSTATTQSADYVVAEHFAPQRNDEQLGNSPASITSKPATTSAAQPSSKVEENMAKATSQPITTAEKEIPELKPIEPEAIMISKEINTTHDQAAATTTAAVASASTTATAESHAVADGIMNDNVLESIGENVQQETVFEDASDIPHADVIPHTTTVTVEEESPIALGQGGVTHEATTSARASASGIPGAFEEVQQTVQEDLPHPTAETVEIARFAEQPVRAQQPEQYESSVVQEATETVTDVGKGVSSTVKNEVNVPSTIPTESENPVAVGGTTAEHPVQEAVTAPTETAHDFSKETTTASKRVSKHDKASAEKHKVARKPSSTGQEPTTPSTPAKSAQSSKHARRPSKQASAPSSPGTTSAAVPGGKKSAIEAAAPIPTSADTVESKHAAGSGSATTIPSPGSATTKPTPGSATTKPTPVSATEEHAAGTTKPAPAAGATATAENETADGKAQTATDGEAAPKKSWFKRMKKSFGKLFH
Has a role in meiosis and sporulation.
O14273
Q5FWF6
ZN789_HUMAN
Zinc finger protein 789
Homo
MFPPARGKELLSFEDVAMYFTREEWGHLNWGQKDLYRDVMLENYRNMVLLGFQFPKPEMICQLENWDEQWILDLPRTGNRKASGSACPGSEARHKMKKLTPKQKFSEDLESYKISVVMQESAEKLSEKLHKCKEFVDSCRLTFPTSGDEYSRGFLQNLNLIQDQNAQTRWKQGRYDEDGKPFNQRSLLLGHERILTRAKSYECSECGKVIRRKAWFDQHQRIHFLENPFECKVCGQAFRQRSALTVHKQCHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPNTHKCSECGQSFGRNVDLIQHQRIHTKEEFFQCGECGKTFSFKRNLFRHQVIHTGSQPYQCVICGKSFKWHTSFIKHQGTHKGQIST
May be involved in transcriptional regulation.
Q5FWF6
A1K8Q1
UBIG_AZOSB
3-demethylubiquinone 3-O-methyltransferase
Azoarcus
MNTNADPAEVQKFSDLAHRWWDPASEFKPLHEINPLRLDWIDGHCGLAGKKVLDVGCGGGLLSEGMAQRGAEVSGIDLSEKALGVARLHLYESGLQVDYQLTSAEAHAATHPAQFDVVTCMEMLEHVPNPESTVHACAQMAKPGGAVFFSTLNRNFKAYLFAVVGAEYLLNLLPRGTHDYAKFIKPSELSRYCRNAGLELVSLSGMTYNPITKVYALSRDTDVNYMVHARKLG
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
A1K8Q1
Q0TEV3
TRMJ_ECOL5
tRNA Cm32/Um32 methyltransferase
Escherichia
MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNAHIVDTLDEALAGCSLVVGTSARSRTLPWPILDPRECGLKSVAEAANTPVALVFGRERVGLTNEELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMAWLATQENGEQVEHEETPYPLVDDLERFYGHLEQTLLATGFIRENHPGQVMNKLRRLFTRARPESQELNILRGILASIEQQNKGNKAE
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
Q0TEV3
P07911
UROM_HUMAN
Uromodulin, secreted form
Homo
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
P07911
Q81GG4
TRPA_BACCR
Tryptophan synthase alpha chain
Bacillus cereus group
MGVEKIKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTLKGIFQALAEVRKEVQMPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIAPLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICELIYATKQKEEA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Q81GG4
Q31910
YCF4_BRAOL
Photosystem I assembly protein Ycf4
Brassica
MTWRSEHIWIDLISGSRKKSNFCWAFLLFLGSLGFVLVGTSSYLGRNLISSFPPQQITFFPQGLVMSFYGIAGLFISCYLWCTILWNVGSGYDLFDRKEGIVRIFRWGFPGKSRRIVLRFLMKDIQSDRTEVKEGVSARRVPYMEIRGQGAIPLIRTDENFTTRREIEQKAAELAYFLRVPIEVF
Seems to be required for the assembly of the photosystem I complex.
Q31910
Q5PQR8
TPRKB_RAT
TP53RK-binding protein
Rattus
MQLTQQLDLFPECKVTLLLFKDVKNAGDLRKKAMEGSIDGSLINANVIVDPFQILVAANKAVHLHKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISESNTSVLIVYVEDGDKQVHQEHLVSQVEGQQVPLESLPEITRLSEVRKVCSTQPEEVSR
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
Q5PQR8
Q5SVQ8
ZBT41_HUMAN
Zinc finger and BTB domain-containing protein 41
Homo
MKKRRKVTSNLEKIHLGYHKDSSEGNVAVECDQVTYTHSAGRPTPEALHCYQELPPSPDQRKLLSSLQYNKNLLKYLNDDRQKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKFLDIIDAVKLLNNENVAPFHSELTEKSSPEETLNELTGRLSNNHQCKFCSRHFCYKKSLENHLAKTHRSLLLGKKHGLKMLERSFSARRSKRNRKCPVKFDDTSDDEQESGDGSDNLNQENFDKEKSDRNDSEDPGSEYNAEEDELEEEMSDEYSDIEEQSEKDHNDAEEEPEAGDSVGNVHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECDICHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKKTKSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTYCEEHFKSRFARLKHQEKFHLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTVHYKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQICNQSFRIKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHEIKSPDDPLSTSEEKLVSLPVEYSSDDKIFQTETKQYMDQPKVYQSEAKTMLQNVSAEVCVPVTLVPVQMPDTPSDLVRHTTTLPPSSHEILSPQPQSTDYPRAADLAFLEKYTLTPQPANIVHPVRPEQMLDPREQSYLGTLLGLDSTTGVQNISTNEHHS
May be involved in transcriptional regulation.
Q5SVQ8
A6LT26
TIG_CLOB8
PPIase
Clostridium
MKAKVEKIETNVIKLEIRVEAEKFDAALTKAYNKNKGRYNIPGFRKGKVPMAMVKKFYGVEVFYDDAVNFAIDESYPEALNAENIKPVDYPQVDIVELGEGKELVYTATVTTYPEVELGEYKGLDIKKPIYEVEDTEIDKQIKEMQEKNARIEVKTEGNIAKGDIAVIDFKGYIDGVAFEGGEGSDYSLEIGSGTFIDNFEEQLIGLAVGDKKEVNVTFPEAYGKEELNGKPAMFEVEIKSIKVKELPELDDEFAKDVSAVDTFAELKENLKKTLEKNNDEKAEREFEEAVITAVIENSKMDIPEVMVNKEIDAMMQDLEGRLKYQGLSLEQYMEFTGNTTEKMRDFMKENAERKVKADLVLEAIAKTEEIKATEEELNARALELGKIYGPKDPEKMAKILVKSQRNMIEKDIILENTLKFLKENCK
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
A6LT26
Q12QH9
TRUB_SHEDO
tRNA-uridine isomerase
Shewanella
MARRSKGRQIDGIVLLDKDTGMSSNYALQRVKRFFNANKAGHTGALDPLATGMLPICLGEATKFSQHLLDADKRYLVTAKLGVRTDTSDSDGEVVQTRDINFTQAQLETALEHFRGDTMQVPSMFSALKHQGQPLYKYAREGIEVPREARPITVFELNFIKLEGDELTLDIHCSKGTYIRTITDDLGEMLGCGAHVIMLRRTQVADYPYDKMVSLADLEALVTQAQQQELAVGELLDPLLLPMDTAVANFPEINLPESMLYYVMQGQAVQASGLKIDVLVRITIGEQRKFVGIGIMNDDGLLAPKRLIVIPAEESPE
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Q12QH9
Q6Q4D0
TONS_ARATH
Protein MGOUN 3
Arabidopsis
MGRLDVAAAKRAYRKAEEVGDRREQARWANNVGDILKNHGEYVDALKWFRIDYDISVKYLPGKDLLPTCQSLGEIYLRLENFEEALIYQKKHLQLAEEANDTVEKQRACTQLGRTYHEMFLKSEDDCEAIQSAKKYFKKAMELAQILKEKPPPGESSGFLEEYINAHNNIGMLDLDLDNPEAARTILKKGLQICDEEEVREYDAARSRLHHNLGNVFMALRSWDEAKKHIEMDINICHKINHVQGEAKGYINLAELHNKTQKYIDALLCYGKASSLAKSMQDESALVEQIEHNTKIVKKSMKVMEELREEELMLKKLSAEMTDAKGTSEERKSMLQVNACLGSLIDKSSMVFAWLKHLQYSKRKKKISDELCDKEKLSDAFMIVGESYQNLRNFRKSLKWFIRSYEGHEAIGNLEGQALAKINIGNGLDCIGEWTGALQAYEEGYRIALKANLPSIQLSALEDIHYIHMMRFGNAQKASELKETIQNLKESEHAEKAECSTQDECSETDSEGHANVSNDRPNACSSPQTPNSLRSERLADLDEANDDVPLISFLQPGKRLFKRKQVSGKQDADTDQTKKDFSVVADSQQTVAGRKRIRVILSDDESETEYELGCPKDSSHKVLRQNEEVSEESMYFDGAINYTDNRAIQDNVEEGSCSYTPLHPIKVAPNVSNCRSLSNNIAVETTGRRKKGSQCDVGDSNGTSCKTGAALVNFHAYSKTEDRKIKIEIENEHIALDSCSHDDESVKVELTCLYYLQLPDDEKSKGLLPIIHHLEYGGRVLKPLELYAILRDSSENVVIEASVDGWVHKRLMKLYMDCCQSLSEKPSMKLLKKLYISEVEDDINVSECELQDISAAPLLCALHVHNIAMLDLSHNMLGNGTMEKLKQLFASSSQMYGALTLDLHCNRFGPTALFQICECPVLFTRLEVLNVSRNRLTDACGSYLSTIVKNCRALYSLNVEHCSLTSRTIQKVANALDSKSGLSQLCIGYNNPVSGSSIQNLLAKLATLSSFAELSMNGIKLSSQVVDSLYALVKTPSLSKLLVGSSGIGTDGAIKVTESLCYQKEETVKLDLSCCGLASSFFIKLNQDVTLTSSILEFNVGGNPITEEGISALGELLRNPCSNIKVLILSKCHLKLAGLLCIIQALSDNKNLEELNLSDNAKIEDETVFGQPVKERSVMVEQEHGTCKSVTSMDKEQELCETNMECDDLEVADSEDEQIEEGTATSSSLSLPRKNHIVKELSTALSMANQLKILDLSNNGFSVEALETLYMSWSSSSSRTGIAQRHVKEETVHFYVEGKMCCGVKSCCRKD
Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks . Specifically recognizes and binds histone H3.1 lacking methylation at 'Lys-27' (H3K27me1) . Involved in structural and functional stabilization of chromatin; represents a link between response to DNA damage and epigenetic gene silencing . Required for cell arrangement in root and shoot apical meristems . May be involved, when interacting with TSA1, in the organization of spindle microtubules .
Q6Q4D0
Q811H0
ZBT42_MOUSE
Protein simiRP58
Mus
MEFPEHGVRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDQPASSRDTVRLNGDIVTVPAFSRLLDFMYEGRLDLHNLPVEDVLAAASYLHMYDIVKVCKGRLRKKDPDLETRTLGTELPGQPPHPLPSWSPAFCQAAPKAKHPSLGVKATHPLPTFGPPSWQVAEQSSGALDLSLKPSPRPEQVHPPCRLQTSLCSSVQQVAQPLVKAEQDSFSEQDSSSPQSADRSPPPVCASAAQGLAVDLEPLHIEGTGSQQLGLPAEPVLDSEELGPSRHLCICPLCCKLFPSTHALQLHLSAHFRERDSVRARLSPEGSVPTCPLCSKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHAVVHTREKPHACRWCERRFTQSGDLYRHVRKFHYGLVKPLLV
Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
Q811H0
Q2NIY3
TRUA_AYWBP
tRNA-uridine isomerase I
Candidatus Phytoplasma asteris
MQHFFYKLILSYDGTFYCGYQKQPQKKTVQQTFEKALKKMTHQNIPTFAASRTDKGVHSQGQTLHFQTTFSLKPKHFQKTLNYLLPPDIRVRQMHFATPNFHARYSAKSKIYQYVFSKKPLNAFNHHFQIFADKFDFVKITKALKFIEGTHNFFAFTSETQPKNFSKTIFQASLKETVHKYILVFHGNGFLKYMIRFLVGSLIEIGKNKFSLEQFQAMLLGNKTKKATLLAPAKALVLKKIFY
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q2NIY3
Q8UVG0
VM3BE_BOTER
ery1
Bothrops
MIQVLLVIICLEAFPYQGSSIILESGNVNDYEVVYPRKVTALSKGAVHPKYEDAMQYEFKVNGEPVVLHLEKNKGLFSEDYSEIHYSPDGREITTYPLVEDHCYYHGRIQNDADSSASISACNGLKGHFKLQGEMYLIEPFKLPDSEAHAVFKYENVEKEDEAPKMCGVTETNWESDEPIKKASLLNLTPEQQAYLDAKKYVEFVVVLDHGMYKKYKDDLDKIKRRIYEIVNTMNEMFIPLNICVALTGLEIWSKGDKINVTSESWFTLILFTNWRGADLLKRKSHDNAQLLTNTDFDGSTIGRAHIGSMCHPYLSVGIIQDYSPVNLLVASTMAHEMGHNLGMHHDNDTCTCGAPSCVMAAAISKDPSKLFSNCSQEYQRKYLIKNRPQCLLNKPLRTDIISPPVCGNELLEVGEECDCGTPENCRDPCCNATTCKLTPGSQCVEGLCCDQCRFRKTGTECRAAKHDCDLPESCTGQSADCPMDDFQRNGHPCQNNNGYCYNGKCPTMENQCIDLVGPKATVAEDSCFKDNQKGNDYGYCRKENGKKIPCEPQDVKCGRLYCNDNSPGQNNPCKCIYFPRNEDRGMVLPGTKCADGKVCSNRHCVDVATAY
Potent activator of prothrombin (F2). Does not elicit any hemorrhagic response. Barely inhibits collagen-induced platelet aggregation. Binds neither collagen, nor the jararhagin monoclonal antibody MAJar3. Hydrolyzes the Aalpha-chain of fibrin and fibrinogen, without affecting the Bbeta- and gamma-chains. Is capable of triggering endothelial pro-inflammatory and procoagulant cell responses, but fails to trigger apoptosis. Induces von Willebrand factor release, and the expression of both ICAM1 and E-selectin (SELE) (without increase in VCAM1) in endothelial cells (HUVEC). Is also able to up-regulate the synthesis of the coagulation factor TF (F3). Enhances nitric oxide (NO) generation, prostacyclin production and interleukin-8 release.
Q8UVG0
P69823
ULAB_ECO57
Ascorbate-specific phosphotransferase enzyme IIB component
Escherichia
MTVRILAVCGNGQGSSMIMKMKVDQFLTQSNIDHTVNSCAVGEYKSELSGADIIIASTHIAGEITVTGNKYVVGVRNMLSPADFGPKLLEVIKEHFPQDVK
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
P69823
Q1WTU0
YBEY_LIGS1
Endoribonuclease YbeY
Ligilactobacillus
MDLEIFDDTNSVPAEKIQLVKDVLEFSGKYLELPEDTEMSVTLMNNEQIHEINLKYRGVDKATDVISFAIEEDDPDELPIILPDDVDFEEPKNIGDMMISMDKVKEQAEYLGHSEDRELGFLTVHGFLHLNGYDHMKAEDEKVMFKLQRDILDAYGLKR
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q1WTU0
P86392
VMPA1_TITSE
Metalloserrulase 1
Tityus
MISYLASIFLLATVSAVPSGRVEVVFPSVETSRSGVKTVKFTALDQDVELKLRSAGEILGKRFAIQDVDVESLRRKIYRDSVNGAALLIDEDGPLTIEGIVNSKLRIQPFESGRITKDGIIAHQIVEVIDDKKSYDRVAVIPENVKRNAENVSRMARDDDCIVVEYYIVTDSAFTKRFKSNSALTNYVTVMFTGVQNLMDTLELGIGVRLLGVTTFTEKTEPSFIKDNLIPGPPAAFDPDVLISAMSKYYCNHQTGLAKDTDLIFLITARGMGDPREDGTVDINTAGIANSAGVCKPCFKSGIATDDSDYNERVDTLAHESVHLLGSPHDGEGPNLVSLEGSPGAANCPAKAGYIMGNRNDKNKYKFSPCTKKCVEYLLSKPTASCIFQQCTDF
Acts as a metalloprotease. Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic.
P86392
Q47AM7
TATA_DECAR
Sec-independent protein translocase protein TatA
Dechloromonas
MGSFSIWHWLIVLVIVMLIFGTKKLRNVGQDLGGAVKGFKDGMKEANADKPAEEAQPTQQVGGHTIDVEVKEKTKS
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q47AM7
A6UW21
TRPD_META3
Anthranilate phosphoribosyltransferase
Methanococcus
MLNKIINREDLSYEESYDLFNDLLNESEIKIGAYLSALQTKGFTANEIAGFAKAMRDNAIAIDLGKGISDTCGTGGDGYSTINISTAVSIILSCFTKVAKHGNVSITSKSGSANVLDALNIKKDCNPEEAKKMIDKTNFVFLFAPNYHPALKKIMPVRKELGIKTIFNILGPLANPANPDYQIMGVNSLDLVEKVGDALKLLGVKKALVVYGNGLDELNPNDYSTICEINENEENKIYKIHPKDIGLTPSNPIPCNSPDESAKRIIKIFSGTINEDRDFILLNAAAALYASNIAKDYKEGLKLAKEVIDNGTVLKKLKEIQKYGE
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
A6UW21
Q4FNF0
YIDD_PELUB
Putative membrane protein insertion efficiency factor
Candidatus Pelagibacter
MNIISNILIGLIKFYKMVISPYLTPSCRYLPTCSEYTIECLRTYGLVKAISKSTKRIFSCHPIKILGGGEGFDPVNKEFKAKK
Could be involved in insertion of integral membrane proteins into the membrane.
Q4FNF0
A6SY03
TPIS_JANMA
Triose-phosphate isomerase
Janthinobacterium
MRRKLVAGNWKMNGSLAANTLLLTEIKSGLGNATSDVAVCVPSPYFAQCQGLLNGAAIALGAQDVSSHEAGAYTGEVSTSMLQEFDCRYVIVGHSERRAYFAETNELIAQKTVRALNAGLTPIVCVGETLDQREAGQTDSVVAEQLNVVLASIAASDLAKIVVAYEPVWAIGTGKTATPAMAQEVHAMLRKQLQAKNAEAAMQVRILYGGSMKPENAKELLAMSDIDGGLIGGAALKAADFLAIVHAA
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
A6SY03
Q5Z355
Y294_NOCFA
Nucleoid-associated protein NFA_2940
Nocardia
MQPGGQFDMQQLLAQAQQMQEAVMQAQAEIAATEVEGQAGGGLVKATIKATGEVQALTIDPKVVDPEDVEGLQDLVIGAINDAMARAQQLAAERLGPLAGGGSMPGLPGF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q5Z355
Q8RX78
UBN1_ARATH
Ubiquitously expressed nuclear protein 1
Arabidopsis
MSEVNEMSGGSIGGELLRASPKVLTAGDRKLLKVELRPGDTTYVSWKKLMRDAGKVNGLSASVPDPPPNANPNLEFRIAPGHPVEIETNEQPHSNRFNAVIEKIERLYKGNDSSDGEELDGAPDDDEYDTEDSFIDDAELDEYFEVDNSTVKHDGFYVNRGKLERMEPSTTSNQQPKKRRRKDSAKPCRDAVDVSDKHTKLSITARKKDQSTAPGSWKTQESPLPSGAQDANTSVPLDDVKHSDRANHQSRNDTSHKSRETGSSSALHQKYSNKSLHQQSTSLLGKSPPNVFAEVTVVRQKENNGMHQLANVTGSRQSSQASKKDGSNVKSKTSILEKAIRELEKVVVESRPPAITENQEADTSSQAVKRRLPRDVKLKLAKVARIAQASQGKHSTELINRLMSIVGHLIQLRSLKRNLKIMIDMGDSATREKDTRFKQINNEVLDMIKAKVSLMESQAIKPEGATSDDFQDSVEKPSLKKFVMDAALEDKLCDLYDIFIDGLDEDQGPQTKKLYVNLAELWPNRLMDYRGIKHAIFRAKERRKALYGNLAKEMDQTKMKKSMKQLVPRTDCTAQPNTELVVQRQHSGEKKLIVDPNATSTSVVTSQTMVDRSNQQQPEKLKGISSSCNPTEETRVVKRKNEAVMAEKQVVLALKKPEHPQTRVIPAPQNLNIPRTTPDLNLPS
May be required for replication-independent chromatin assembly.
Q8RX78
B4SUI9
TREA_SALNS
Alpha,alpha-trehalose glucohydrolase
Salmonella
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESEHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKEYLPQLQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAEASQYDALANARQKAIEMHLWNNKEGWYADYDLKNNKIRDQLTAAALFPLYVNAAAKDRAAKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVAMEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSATPTKTPSAATQ
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
B4SUI9
Q8T0W4
VKT2_PIMHY
Cysteine-rich venom protein 2
Pimpla
MNAKIVALLIVVGFVGMFNVATAADPLCSLEPAVGLCKASIPRFASVGGKCQEFIYGGCGGNANNFQTQAECEAKCG
Serine protease inhibitor.
Q8T0W4
Q7U330
TRUB_HELHP
tRNA-uridine isomerase
Helicobacter
MANALLVAAYKPPFLSSNACLSRLKKHFGMSKAGYLGTLDPFAKGVLVVGFGSYTRLFPHLQKVPKAYRATLWLGAKSASLDIEHIESIEIIPEYNQSDIEKILFSLKGTFDYTPPAFSAKHINGQRAYKLAREGKVFTLQQIQMSIYNITLLSYHHPFVHFEVSVSEGAYVRSIGEIIAKKLGVNGVLSSLERISEGQMSVSATEQIRILNPLEYLPYPQLENMHRFSKQMYDGKKITLKNAQKGKYIVCFEDFFSIIEIFSNGGIQYILNRIEYVDTFKKTR
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Q7U330
Q7M715
TR117_MOUSE
Taste receptor type 2 member 117
Mus
MKHFWKILSVISQSTLSVILIVELVIGIIGNGFMVLVHCMDWVKKKKMSLVNQILTALSISRIFQLCLLFISLVINFSYTDLTTSSRMIQVMYNAWILANHFSIWIATCLTVLYFLKIANFSNSFFLYLKWRVEKVVSVTLLVSLLLLILNILLTNLETDMWTNEYQRNISCSFSSHYYAKCHRQVLRLHIIFLSVPVVLSLSTFLLLIFSLWTHHKRMQQHVQGGRDARTTAHFKALQTVIAFFLLYSIFILSVLIQIWKYELLKKNLFVVFCEVVYIAFPTFHSYILIVGDMKLRQACLPLCIIAAEIQTTLCRNFRSLKYFRLCCIF
Putative taste receptor which may play a role in the perception of bitterness.
Q7M715
Q31HG2
TPIS_HYDCU
Triose-phosphate isomerase
Hydrogenovibrio
MRQLFVAGNWKMHGDKASIKTLVTGLNAKADSVGDVLVAVCPPAIYLDYTKNCLMAGEIALGGQNMAIEPVQGAYTGETSASMLKDVGCQYVILGHSERRAIYGETDQDIAAKVKTALDSGLTPILCVGETLEERESGQLESVISQQLDAVISEVGIDQFADVVIAYEPVWAIGTGKTASAQQAQDVHAFIRGQLAKLNPSVAEKVIIQYGGSVKPNNASELFSQPDIDGGLIGGASLNADDFIAICQAAGEQ
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q31HG2
C5XNN6
THI41_SORBI
Thiazole biosynthetic enzyme 1
Sorghum
MATTAASSLLKSSFAGSRLPSATRAPSSVVVSTGGAPRTAAISASISSSNPPYDLTSFKFSPIKESIVSREMTRRYMTDMITHADTDVVIVGAGSAGLSCAYELSKDPTVRVAIVEQSVSPGGGAWLGGQLFSAMVVRKPAHLFLDELGVAYDEAADDYVVVKHAALFTSTVMSAVLARPNVKLFNAVAVEDLIVKGGRVGGVVTNWALVSMNHDTQSCMDPNVMEAKVVVSSCGHDGPFGATGVKRLQDIGMIAAVPGMKALDMNAAEDAIVRLTREVVPGMIVTGMEVAEIDGAPRMGPTFGAMMISGQKAAHLALKALGRPNAVDGTIPKVSPALREEFVIASKDDEVVDA
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
C5XNN6
P38141
THI2_YEAST
Thiamine biosynthesis regulatory protein
Saccharomyces
MVNSKRQQRSKKVASSSKVPPTKGRTFTGCWACRFKKRRCDENRPICSLCAKHGDNCSYDIRLMWLEENIYKVRKHSLISSLQARKSKSKPLCQKISKSRFKQMTHFRQLSPPTSDCEDSVHEASKETTLPNDNTFTISVRRLKIYNNAVASVFGSMTNRDYTQKRIDKKLDELLNMVENDISVVNLNCSKHGPYSVFRANPAAVTSALTDQLPSPGHSMSSAEETTTAALSSPPEDSTSLIDIIQGKIFGILWFNCYGNMILNRQEYTTWFINKMRNSLTTEFIRFLGKIIDDPDINMASCLFKECIARWSCVDWQSIAITMLVIIHGYTCPNLTKLLRVWFLQQKLLRFSMYPLVNFIINNTQDLDVLYHCNGLLGNADLFEDPYQDELTSELHVLVTERLVNSWKDTILQQLCSCQDTTLSCSQLRYWQLQLKCNQQFYKDVYAMQD
Positive regulator of thiamine biosynthesis.
P38141
C1AE25
THIM_GEMAT
4-methyl-5-beta-hydroxyethylthiazole kinase
Gemmatimonas
MDAPSSASGPTQPRLSPADALAALRASAPLTQCITNYVAMQIAANTLLAAGAAPAMIHTVEESGAFAGLARAVTINIGTLSPAWVDGMKAAIDGATAVGTPWVLDPVAHYASAYRSAVARDLLSRRPTILRGNASEILALAGGNTAARGVDAADPVTAAGAAASALAREYGSVVAVTGAVDLVTDGTRVAMVSGGSPWMPQVTALGCSLTCLMGAFAAVTAPLEATVAALTLFAEAGARAHAHSEGPGSFAWRFLDALAAVTPDDLTGTERVSWNAP
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
C1AE25
Q9ABM9
TRMD_CAUVC
tRNA [GM37] methyltransferase
Caulobacter
MPFTATVLTMFPEAFPGPLGVSMIGTAWKEQDLWRLETLDIRAFSKDKRGFLDDTPAGGGAGAVLKADVIASALDSLERDGRPLLYMSARGRPLTQARVREWSKAPGIVVLCGRFEGVDQRVLDARGFEEVSVGDAVLAGGEAAAMVVIEACVRLAPGVLGNIESTLEESFEDGLLEHPQYTRPRTFEELDIPEVLLSGDHKKIDQWRKRMREETTRERRPDLWEAHLANQQAKGDPKPGKPKET
Specifically methylates guanosine-37 in various tRNAs.
Q9ABM9
P31831
TACY_LISIV
Thiol-activated cytolysin
Listeria
MKKIMLLLMTLLLVSLPLAQEAQADASVYSYQGIISHMAPPASPPAKPKTPVEKKNAAQIDQYIQGLDYDKNNILVYDGEAVKNVPPKAGYKEGNQYIVVEKKKKSINQNNADIQVINSLASLTYPGALVKANSELVENQPDVLPVKRDSVTLSIDLPGMVNHDNEIVVQNATKSNINDGVNTLVDRWNNKYSEEYPNISAKIDYDQEMAYSESQLVAKFGAAFKAVNNSLNVNFGAISEGKVQEEVINFKQIYYTVNVNEPTSPSRFFGKSVTKENLQALGVNAENPPAYISSVAYGRDIFVKLSTSSHSTRVKAAFDTAFKGKSVKGDTELENIIQNASFKAVIYGGSAKDEVEIIDGDLSKLRDILKQGANFDKKNPGVPIAYTTNFLKDNQLAVVKNNSEYIETTSKAYSDGKINLDHSGAYVARFNVTWDEVSYDANGNEVVEHKKWSENDKDKLAHFTTSIYLPGNARNINIHAKECTGLAWEWWRTVVDDRNLPLVKNRNVCIWGTTLYPAYSDTVDNPIK
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.
P31831
Q66I85
YJU2B_DANRE
Coiled-coil domain-containing protein 130
Danio
MGERKGVNKWYPPDFDPAKHGSINGYYKTHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPATCDYVIVSGAQRKEERWDMAENEQILTTERNEKEKLETDAMYKLDHGGKDKEKLRAAIPSLNELQEHQSGWKDDFQLNSALRRKFRTEKKVIAEEEEKDNAVRLRTGLSIPLVPEREEDKKLASLLTFQSPDSYEDKKQWKRQEISSRSWFNSPSSAAGGAAGSLLQKLGQQGRGAAVAKALSSSTSTLPILVRRKSESSKSETNNTMSTILPVDTHPAAKDTDATDLPSIVNNINVSINTDINSCTTDACKASSSSEEENSIDSCATGKSLVADYSDSDSGSEV
May be involved in mRNA splicing.
Q66I85
P59427
TYSY_BUCBP
Thymidylate synthase
Buchnera
MKSYLVLLKKILKEGSNRKDRTGIGTLSVFGYHMEFNLKLGFPLITTKKCHFPAIVHELLWFLKGDTNIKYLNDHNISIWNPWADERGYLGPIYGEQWRSWKTKDGRVIDQIDNVIHLIKNNPNSRRIVVSSWNVGDLHKMALLPCHVLFQFHVVDHVLHCQLYQRSCDVFLGLPFNIASYSLLTHMIAQQCNLKVGNFIWTGGDVHLYKNHIKQAKKQILRRPYLLPKLVINRKPTQIFNYLLQDFNLLNYKYHPSIHAKIAI
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
P59427
Q2YX99
TMCAL_STAAB
tRNA(Met) cytidine acetate ligase
Staphylococcus
MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMALSTADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIEQSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKHAKNINAISIKRENAQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQIIAMTTESLKNIYTVNEGFENRLKSTINEATDFHHFVKSLKTKRYTYTHIQRLLMNVLLNIKPTDVTRNIRAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYNAISGQQQTDFNTPVIQQYR
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
Q2YX99
Q4R963
TCPG_MACFA
CCT-gamma
Macaca
MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGGGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDINDSDMMLNIINSSITTKAISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYAKVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDVKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Q4R963
Q886N9
UPPS_PSESM
Undecaprenyl pyrophosphate synthase
Pseudomonas
MEKIKSAGPSSVPRHVAIIMDGNNRWARKRLLPGVAGHKAGVDAVRAVIEVCAEAKVEVLTLFAFSSENWQRPAEEVGALMELFFTALRRETKRLNENDISLRIIGDRSRFHPELQAAMREAEVRTSGNSRFVLQIAANYGGQWDIAQAAQRLAREVQAGHLQPEDITPQLLQTCLATGDLPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHDAMRAALADFASRQRRFGKTSEQVEAGARA
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
Q886N9
Q27GK7
TPR4_ARATH
WUS-interacting protein 2
Arabidopsis
MSSLSRELVFLILQFLDEEKFKDTVHRLEKESGFFFNMRYFEDSVTAGEWDDVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDKKDHAKAVDILVKELKVFSTFNEELFKEITMLLTLTNFRENEQLSKYGDTKSARGIMLGELKKLIEANPLFRDKLQFPSLKNSRLRTLINQSLNWQHQLCKNPRPNPDIKTLFVDHTCGHPNGAHTPSPTTNHLMGSVPKVGGFPPLGAHGPFQPTPAPLTTSLAGWMPNPSVQHPTVSAGPIGLGAPNSAVSMLKRERPRSPPTNSLSMDYQTADSESVLKRPRPFGISDGVNNLPVNVLPVTYPGQSHAHATYSTDDLPKNVSRILSQGSAIKSMDFHPVQQTMLLVGTNLGDIAIWEVGSREKLVSRSFKVWDLATCTVNLQASLASEYTAAVNRVVWSPDGGLLGVAYSKHIVHIYSYHGGEDLRNHLEIDAHAGNVNDLAFSQPNQQLCVVTCGEDKTIKVWDAVTGNKLHTFEGHEAPVYSVCPHQKENIQFIFSTAVDGKIKAWLYDNMGSRVDYDAPGRSCTSMAYCADGTRLFSCGTSKEGESFIVEWNESEGAVKRTYLGLGKRSVGVVQFDTMKNKFLVAGDEFQVKFWDMDSVDLLSSTAAEGGLPSSPCLRINKEGTLLAVSTTDNGIKILANAEGSRILHSMANRGLDSSRAPPGSVAKGPIVGTFGTPNSSTGMSLSMGERSGPVASVTGLNGDNRSLPDVKPRIADDAEKSKTWKLTEISERSQLRTLRLPDTLLPARVVKLIYTNSGGAILALAENAAHKLWKWQKSERNLLGKANSNVPPQLWQPSSGVLMTNDTREGNKEDVVPCFALSKNDSYVMSASGGKISLFNMMTFKTMTTFMAPPPAATSLAFHPQDNNIIAIGMDDSSIQIYNVRVDEVKSKLKGHQKRVTGLAFSNVLNVLVSSGADSQLCVWSMDGWEKQASKQIQIPSGHSPNPLAHTRVQFHQDQIHVLVVHASQLAIYEAPKLENMKQWIPKESSGSVTDAVYSCDSQSIYAAFDDGSVSILTATTLQLKCRIGPNSYLPSNPSSRVYPATVAAHPSEPNQFAVGLTDGGVHVIEPPGPEGKWGISAPPENGAGPSVSSAPGSDQQPR
Transcription corepressor of Zinc finger transcription factors GAF1/IDD2 and ENY/IDD1 in regulation of gibberellin homeostasis and signaling.
Q27GK7
Q9XFG3
TBG_PHYPA
Gamma-tubulin
Physcomitrium
MPREIITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFATQGGDRKDVFFYQADDEHYIPRALLIDLEPRVINSIQNSEYRNLYNHENVFVADHGGGAGNNWASGYHQGEQVEEDIMDMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLEALNDRYSKKLVQTYSVFPNQMETSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALNRIAVDRLHIPNPTFAQTNSLVSTVMSASTTTLRYPGYMNNDLVGLVASLIPTPRCHFLMTGYTPLTVERQANAIRKTTVLDVMRRLLQAKNIMVSSYARTKEASQAKYISILNIIQGEVDPTQVHKSLQRIRERKLANFIEWGPASIQVALSRKSPYVQTAHRVSGLMLASHTSIRHLFSKCISQYEKLRKKQAFLDNYRKFPMFADNDLSEFDESREIVQNLVDEYKACESADYIKWGMEDRGKQVSGEGNTSGTVDSRVGAS
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
Q9XFG3
Q5JDJ1
TRPB2_THEKO
Tryptophan synthase beta chain 2
Thermococcus
MKAVLPDSKIPKRWYNILPDLPEPLAPPLDPETDEPMEPEKLLRIFAEELVKQEMSTDRYIEIPKEVREIYSKIGRPTPLFRATNLERALGTPARIYFKYEGATVTGSHKINTALAQAYYAKRQGIERLVTETGAGQWGTALSLAGALLGLNVRVYMARASYQQKPYRKTIMRLYGAEIYPSPSDRTEIGRKFLAEDPNHPGGLGIAISEAIEDVLRDEKARYALGSVLNHVLMHQTVIGLEAQEQMKEFEEPDVIIGCVGGGSNFAGLAYPFVRDVLKGEAEYEFIAVEPKAAPSMTRGVYKYDYGDSGGYTPKMKMHTLGHTYYVPPIHAGGLRYHGLAPTLSVLINHGIVKPVAYHQNEVFQAAHLFAKTEGIVPAPESAHAIKGAIDRALEAKREGREEVILFNLSGHGFLDLKGYEDYLDGKLEDYEPEHFPALDNY
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q5JDJ1
E1QU22
TSR3_VULDI
20S S rRNA accumulation protein 3 homolog
Vulcanisaeta
MIPRVFIYRLPQDDPRKNTAIKLVRFGFAQLVDSIKALPSGSIILDPTVKTPLTPSDRVIAESRGLSLIDCSWKRAVDVHTKFIRGKFIRRRLPLLIAANPTHYGKPYILSTIEAVAAALYIMGFKDEAMEVLRLYKWGPNFIIINQKYLERYAAGDLSPERELLGVDDVDNGLEQLMRVLTNGD
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
E1QU22
Q00835
TRI5_FUSPO
Sesquiterpene cyclase
Fusarium
MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSDDPYAAMMNYFNDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQFDERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSDEISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMVTIECFMHGYVTWHLCDHRYRLNEISEKVKEQKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQLANVRSKDVKNVKQIEKPLLSSIELVE
TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
Q00835
B9M7R9
YIDC_GEODF
Membrane protein YidC
Geotalea
MEKRVVIAVILSIVVLYAFSYMFPPPVANQKEKAGPVAAVQSQPSSAKLSAIDSVPAAATPQAGLAARNIVVDTDLFIAVFSTKGGGLQSFQLKHYKDKAGAVGRDIVLKNESDGDKLSLLSEGKSFGLEPSLVFQSSAKDTKLAGTEKSSIEFTVTSQTGVILKKVYSFSGNGYGINLHQELINTGSSRVEGAISLINYNRLVAETGDGRYEVYGPVTMAGDKVITDKVSDIAKGPKQFDNNVSWSAFADKYFMDAVIAVKNSIASARVAKISDNYVQTNVTSSPLSLNPGQSASMDYRLFYGPKDLDILKAQGSRLEEAIDFGWFSALAKPLLRSIKFFYSYTHNYGLAIIIITIILKVLFFPLTHKSYKSMKEMQKLQPKMVELKEKFKNDRDAMNRAVMDLYKTHKVNPMGGCLPMLVQIPVFFALYKALMFSIELRHAPFVLWITDLSAKDPYYVTPIIMGVTMFIQQKMTPTNMDPIQAKMMLALPVVFTFMFLNFPAGLVLYWLINNILTIAQQAYINKSLPA
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
B9M7R9
Q0WQK2
ZDHC9_ARATH
Zinc finger DHHC domain-containing protein At3g26935
Arabidopsis
MYVVPPPQRSDSGSNGDLRVYQTWKGSNIFFLQGRFVFGPDVRSLALTICLIAVPVTIFCIFVARKLIDDFSDSWGVSIVAVAVVFTIYDLILLLLTSGRDPGIIPRNAHPPEPETLDGNMDAGAGQTPQLRLPRIKEVQLNGITFKVKYCDTCMLYRPPRCSHCSICNNCVERFDHHCPWVGQCIGMRNYRFFFMFVFSTTLLCIYVFAFCWVYIRKIMESEHTTTWKAMLKTPASIVLIIYTFISMWFVGGLTVFHLYLISTNQTTYENFRYRYDRRSNPHNKGVVNNFKETFFSTIPPSKNDFRAMVQREPPLPPRSVAGGFMSPNMGKANDEIEMGRKAVWADMGPAMSDHGDGKHGNNERLHVKDGELGELSPDIRATVDEQSDRPSMHPRRSSWGRKSGSWDMSPEVMALAARVGEQNQNGGGSSSGSGLVTENRPT
Palmitoyl acyltransferase.
Q0WQK2
Q39IR6
UBID_BURL3
Polyprenyl p-hydroxybenzoate decarboxylase
Burkholderia cepacia complex
MKYKDLRDFIQRLEALGELRRVTQPVSPVLEMTELCDRVLRAGGPALLFNAPTGYDFPVLGNLFGTPRRVALGMGVDAGDDAALDSLRDLGRLLSALKEPDPPKSLKDAGKLLSLAKAVWDMAPKSVSSPPCQEIVWEGADVDLNRLPIQTCWPGDAGPLVTWGLTVTRGPNKSRQNLGIYRQQLIGRNKLIMRWLAHRGGALDFREFALQNPGKPYPVAVVLGADPATTLGAVTPVPDSLSEYQFAGLLRGSRTELAKCLTPGVDTLQVPARAEIVLEGFIYPQEGAPAPAPAGAPPRPAGNASAKYEHALEGPYGDHTGYYNEQEWFPVFTVERITMRRDAIYHSTYTGKPPDEPAVLGVALNEVFVPLLQKQFTEITDFYLPPEGCSYRMAIVQMKKSYAGHAKRVMFGVWSFLRQFMYTKFIVVVDEDVNIRDWKEVIWAITTRVDPVRDTVMVDSTPIDYLDFASPVAGLGSKMGLDATNKWPGETNREWGRPIEMDAAVKARVDRLWQEIGL
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Q39IR6
Q8KGF8
TAL_CHLTE
Probable transaldolase
Chlorobaculum
MKFFIDTASLDEIKAANELGVLDGVTTNPSLIAKIVKDSTNFTYADFKAHIAKICEIVDGPVSAEVTTLKAGEMIAQGEELAAIHKNIVVKCPLTVDGLKAIKHFSSNGIKTNATLVFSPTQALLAAKAGADFVSPFVGRLDDISTSGMELVRQIVTIYDNYGYLTEVIVASVRNPLHVVESAMVGADIATIPYSVIKQLANHPLTDKGLEKFMEDAAVMKP
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Q8KGF8
Q0A5V9
UBIA_ALKEH
4-HB polyprenyltransferase
Alkalilimnicola
MEMTADYLRDRAWQYAQLTRLNRPIGNFLLLWPMLWGLWIAAKGLPDLKVLVVFVLGVLIMRAAGCVINDYADRDFDGHVKRTTHRPMANGRVSEREALTLFVVLCLVAFGLVLLMNPLTIALSLVAVALAATYPFMKRYTHFPQVHLGAAFGWAIPMAFAAQTGAVAPVAWLLFLSAVLWATIYDTQYAMVDRDDDLKIGVKSTAVLFGQADRAIIGVLQGVMLAVLVAAGLVVGLGAFWYLGLAAAAALFAYQQWLIRERRREDCFRAFLNNNWLGGLIFLGLLLDLHLGG
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Q0A5V9
B4U3P4
UVRB_STREM
Excinuclease ABC subunit B
Streptococcus
MIDKRDFKAFKLVSKYAPSGDQPQAIEALVDNIESGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDQLLNALVDIQFERNDIDFQRGRFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGKVLGDADHLVLFPATHFVTNDEHMEQSISKIQAELADQLKLFEAEGKLLEAQRLRQRTEYDIEMLREMGYTNGVENYSRHMDGRSAGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDKARKQMLVDYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRPTGLLDPEVEVRPSMGQMDDLLGEINLRVERGERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNADGHVIMYADRMTDSMQRAIDETARRRAIQMAYNEEHGIIPQTIKKDIRDLISISRAVEAKATEAETNYESMTRSERQEAIKQLQKNMQEAAELLDFELAAQLRDLILELKAID
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
B4U3P4
A1BEF7
THIG_CHLPD
Thiazole synthase
Chlorobium
MDFLHLGSFVFSSRLILGTGKFSNADLMIEAIKASGAQLVTVALRRFNREQIADDLFGPLSALQGITLMPNTSGASTAREAIHAAHIARELSGSPFIKVEIHPNPQHLMPDALETWEASRILAKEGFLVMPYIPADPVLAKRLEEVGCASVMPLGSAIGSGQGLANAGMIELIIRESGIPVIVDAGLRAPSEAAAAMEMGCGAVLVNSAVAVAGNPPEMANAFAEAVRAGRRAFKAELMPKSSFALSTSPLTTFLGKKS
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
A1BEF7
Q03774
TRM82_YEAST
Transfer RNA methyltransferase 82
Saccharomyces
MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISLSAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNLVTKKEEIYPLYNVSSLRKHGEHYS
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Q03774
A1RV13
UPP_PYRIL
UPRTase
Pyrobaculum
MPVKIIDHVYAQYLLTQLRNRNTKGIDFRKGLVRLGRIVGYELVRYFPTREVEVETPLGKAVGIEILGLDKVIIVQILRAAMPFVEGLLKAFPQARLGVIAARRKEEGGVVDVEVFYSKIPTVEREDIVIVADPMLATGITMTRAIEEVYRVGQPGRLIVVSVIATPVGIERVLSKYPETEIFVVAIDPTLNDKAFIVPGLGDAGDRAFST
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
A1RV13
P37610
TAUD_ECOLI
Sulfate starvation-induced protein 3
Escherichia
MSERLSITPLGPYIGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDVTFIETPPAGAILAAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQPNDIAIWDNRVTQHYANADYLPQRRIMHRATILGDKPFYRAG
Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable intermediate . Is required for the utilization of taurine (2-aminoethanesulfonate) as an alternative sulfur source for growth in the absence of sulfate . To a lesser extent, pentanesulfonate, 3-(N-morpholino)propanesulfonate and 1,3-dioxo-2-isoindolineethanesulfonate are also desulfonated by this enzyme in vitro; however, desulfonation by TauD of organosulfonates other than taurine seem to be of little or no importance for sulfur metabolism in vivo .
P37610
B2RXF5
ZBT42_HUMAN
Zinc finger and BTB domain-containing protein 42
Homo
MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEKDRSLDPGNPAPGAEPAQPPCPWPVWTADLCPAARKAKLPPFGVKAALPPRASGPPPCQVPEESDQALDLSLKSGPRQERVHPPCVLQTPLCSQRQPGAQPLVKDERDSLSEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEGSRELELGAGRLASEDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCGKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDLYRHVRKFHCGLVKSLLV
Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
B2RXF5
Q084N8
TRPB_SHEFN
Tryptophan synthase beta chain
Shewanella
MTELKLNPYFGEYGGMYVPQILVPALKQLETAFVEAQQDESFIAEFTDLLKNYAGRPTALTLTRNLSPNPLVKIYLKREDLLHGGAHKTNQVLGQALLAKRMGKKEIIAETGAGQHGVATALACALLGLKCKVYMGAKDIERQSPNVFRMKLMGAEVIPVTSGSSTLKDACNEAMRDWSASYDKAHYLLGTAAGPHPFPTIVREFQRMIGEETKKQILEKEGRLPDAVIACVGGGSNAIGMFADFIDEPSVELIGVEPAGKGIDTPMHGAPLKHGKTGIFFGMKSPLMQNSDGQIEESYSVSAGLDFPSVGPQHAHLNAIGRARYESATDDEALEMFQTLARCEGIIPALESAHALAYAVRMAKEATKETILVVNLSGRGDKDIFTVADILEAKQKQQESGNE
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q084N8
Q4L882
TRUA_STAHJ
tRNA-uridine isomerase I
Staphylococcus
MRILVNISYQGSQFLGFQIQQQGRTVQQQFEKILKRMHRRHVRIHPSSRTDRGVHAYEQFFHFDTDLNIEPKQWKYAMNSALPDDIYVKEVQQVDDHFHCRYDCLGKRYRYKVYQATHRNPFESGLKTFIKEDLNYSKMNEAAKHFIGTHDFTGFCSQKTEVESKVRTLYQSEIIQTDEGFDYVVTGSGFLYNMVRVLVAFLIEVGKGKRHASEVSTLLNEKNRDSVPFTAPAEGLYLEKIYLTEKDLTTDFGDNIKIHRKKSLQND
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q4L882
Q2VY69
ZN284_HUMAN
Zinc finger protein 284
Homo
MTMFKEAVTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVGHQLSHRDTFHFQREEKFWIMETATQREGNSGGKIQTELESVPETGPHEEWSCQQIWEQTASELTRPQDSISSSQFSTQGDVPSQVDAGLSIIHIGETPSEHGKCKKFFSDVSILDLHQQLHSGKISHTCNEYRKRFCYSSALCLHQKVHMGEKRYKCDVCSKAFSQNSQLQTHQRIHTGEKPFKCEQCGKSFSRRSGMYVHCKLHTGEKPHICEECGKAFIHNSQLREHQRIHTGEKPFKCYICGKSFHSRSNLNRHSMVHMQEKSFRCDTCSNSFGQRSALNSHCMDHTKEKLYKCEECGRSFTCRQDLCKHQMDHTGDKPYNCNVCGKGFRWSSCLSRHQRVHNGETTFKCDGCGKRFYMNSQGHSHQRAYREEELYKCQKCGKGYISKFNLDLHQRVHTGERPYNCKECGKSFRWASGILRHKRLHTGEKPFKCEECGKRFTENSKLRFHQRIHTGEKPYKCEECGKGFRWASTHLTHQRLHSREKLFQCEDCGKSSEHSSCLQDQQSDHSGEKTSKCEDCGKRYERRLNLDMILSLFLNDI
May be involved in transcriptional regulation.
Q2VY69
B4RWG2
Y3196_ALTMD
Nucleotide-binding protein MADE_1004170
Alteromonas
MKLIIISGRSGSGKSVALRALEDLGYYCVDNIPVNLLPTLTHTVVDEYDQVAVSIDVRNLPKNPDDLVEILDYLPSSWSMTIVYIDASDDVLVKRFSETRRLHPLAKLNKSLSEAIRAESALLAPIAERADLYLDTDKLTIHQLAELIRERILGKKSSRLVLVFESFGFKHGIPKDADYVFDARFLPNPHWEPDLKHLTGLDAPVEVFLGSQPVVTKFIWQIQNLITTWLPHLERNNRSYVTVAIGCTGGQHRSVYIAQTLSKTFSEIHPDVQIRHRELNQ
Displays ATPase and GTPase activities.
B4RWG2
B5GW45
TMUUS_STRCL
Type I terpene synthase
Streptomyces
MSLNHSDLMFYCPVDDLPHPAASGVNDRTLDWASGQGIPTADRDAGRLRAMAPGLLAARIAPDARGPVLDAFADHHTWLFAFDDEYCDRADGSGITEWASFLARLHRVVETGESALLPGNPYGLALRDIACRLSTYTTPAQLAEWLEALRSYFAALVWERSRRRDDDRLQSLDDYLLLRLRNGAMHTSITLLDTVNGYVLPRELRETPGVRALVEMTALLVSVDNDILSHHKESTSGTREANLLDVLGRTGHTTPGEAVAQAVALRNEIMRQFVRVAERVRTPAAVPELYRFTTGLARWIRANLDFSLTTTRYTGPVTERAALSPHEVPPLSGQGPAPARSDVIGWWWRIPEPLPEPGSDGADTPVRKRRAGDRPPTAGRGGAPHHQRTGPPPPVLPGGITASRSSGLQQSTWRREHR
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (+)-T-muurolol via a 1,10-cyclization, which requires isomerization of FPP to nerolidyl diphosphate (NPP) and then abstraction of the pyrophosphate from intermediate NPP leading to a (E,Z)-germacradienyl (helminthogermacradienyl) cation.
B5GW45
B7LJY3
UVRB_ESCF3
Excinuclease ABC subunit B
Escherichia
MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
B7LJY3
Q8E7Q5
TRUA_STRA3
tRNA-uridine isomerase I
Streptococcus
MTRYKAQISYDGSAFSGFQRQPNCRTVQEEIERTLKRLNSGNDVIIHGAGRTDAGVHAYGQVIHFDLPQARDVEKLRFGLDTQCPDDIDIVKVEQVSDDFHCRYDKHIKTYEFLVDIGRPKNPMMRNYATHYPYPVIIELMQEAIKDLVGTHDFTGFTASGTSVENKVRTIFDAKIQFEASKNLLIFTFTGNGFLYKQVRNMVGTLLKIGNGRMPISQIKTILQAKNRDLAGPTAAGNGLYLKEIIYEDKECFSNFRK
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q8E7Q5
P77288
YFCV_ECOLI
Uncharacterized fimbrial-like protein YfcV
Escherichia
MSKFVKTAIAAAMVMGAFTSTATIAAGNNGTARFYGTIEDSVCSIVPDDHKLEVDMGDIGAEKLKNNGTTTPKNFQIRLQDCVFDTQETMTTTFTGTVSSANSGNYYTIFNTDTGAAFNNVSLAIGDSLGTSYKSGMGIDQKIVKDTATNKGKAKQTLNFKAWLVGAADAPDLGNFEANTTFQITYL
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
P77288
Q11IP4
XGPT_CHESB
Xanthine phosphoribosyltransferase
unclassified Chelativorans
MSLPEKAFPVSWDQFHRDARALAWRLAGTNGRWQAIVCITRGGLVPAAVIARELGIRLIETVCIASYHDYSEQGELKVLKEISPSLLEEDGQNILIVDDLTDTGKTAAIVRAMMPKAHFATVYAKPKGRPLVDTFVTEVSQDTWIYFPWDLGFSYQKPIADGEIG
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Q11IP4
A7FMH4
TYPH_YERP3
TdRPase
Yersinia
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGPLVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLTDMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKLQAVLDNGKAAEVFGRMVAAQKGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALGMAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLAVIHANNEDDWQQAAEAVRAAITLGNNAPEETPVIYRRITE
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
A7FMH4
P44560
TATC_HAEIN
Sec-independent protein translocase protein TatC
Haemophilus
MSNVDESQPLITHLVELRNRLLRCVICVVLVFVALVYFSNDIYHFVAAPLTAVMPKGATMIATNIQTPFFTPIKLTAIVAIFISVPYLLYQIWAFIAPALYQHEKRMIYPLLFSSTILFYCGVAFAYYIVFPLVFSFFTQTAPEGVTIATDISSYLDFALALFLAFGVCFEVPIAIILLCWTGITTVKALSEKRPYIIVAAFFIGMLLTPPDVFSQTLLAIPMCLLFELGLLVARFYQPKDDESAVKNNDESEKTQ
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
P44560
O82827
UPPS_MICLU
Undecaprenyl pyrophosphate synthase
Micrococcus
MFPIKKRKAIKNNNINAAQIPKHIAIIMDGNGRWAKQKKMPRIKGHYEGMQTVKKITRYASDLGVKYLTLYAFSTENWSRPKDEVNYLMKLPGDFLNTFLPELIEKNVKVETIGFIDDLPDHTKKAVLEAKEKTKHNTGLTLVFALNYGGRKEIISAVQLIAERYKSGEISLDEISETHFNEYLFTANMPDPELLIRTSGEERLSNFLIWQCSYSEFVFIDEFWPDFNEESLAQCISIYQNRHRRFGGL
Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate. UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
O82827
P48970
UNIV_STRPU
Univin
Strongylocentrotus
MDVSKVLILTLIWLLTADSAPPDYVTLTRKMESKILRVMGLSERPRPKPNATAPQYMWDLYRQQMAATEGAAASRGGETEIGKEEEEDGRPCSETKLSSNIIRSVSHTGGDLRASNSTSLQQILLFDVASIPHAETIEAADLRLEIPALPSATDVPSLAVRIYQLESRTRLNSIVSLKDKRLRLLDVVLADLSQGYAGTIDILSTVNSWRSKKTSNHGLLLHVELMSTSGNNRRGSQVIKELGAISKKCTANLIVTSSEYRQCSKRNRRNKRQAESEAPADISSFPTASLTNLCQRHRLFVSFRDVGWENWIIAPMGYQAYYCDGECPFPLGERLNGTNHAIIQTLVNSIDNRAVPKVCCAPTKLSGISMLYFDNNENVVLRQYEDMVVEACGCR
Could have a critical role in early developmental decisions in the sea urchin embryo.
P48970
A4YM32
UREF_BRASO
Urease accessory protein UreF
unclassified Bradyrhizobium
MTTNDAGRIPSAAGGAELAALYRLLTWLSPAFPIGGFSYSSGLEWAVEAGDICDAAALRGWLATMLTDGSGFCDAAFLVHAHRATELDDIKRLSEVAELAAAFVPSRERQLETAAQGRAFIEIARSAWSCAGLDEAVAQCDVVVYPVAVGMVGALHGVPLEPLLHGFLHALVSNWISAGSRLVPLGQTDSQRVLAALEPVVVATADRSLHASLDDIGSATFRADLASLRHETQYTRLFRS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
A4YM32
Q85FG7
TI214_ADICA
Translocon at the inner envelope membrane of chloroplasts 214
Adiantum
MNTKILLSLPWPKLMDPYMLLGFYYGLLTTLPVGPSQILCVRSFLLGGNLSGLISISGSVLAQLITASSIYCSPIYLLLLRPHLLTIVAIPYTLLFCLVIKDFPNYQILRPVTSLRDSRVARLFLISFFFQILNPIMLPNSVLTRLIYLYFFRYSTNTVFMVSTFMGWLTGQAAFNFFSRLLLSRVKGDSPILYLVAKRFIYATFSIVSISYAVAYLGRAPVSFWTKKFMNESHDREMNLWEIAEYSDLLWWFFKPWPTSFFDPSRANRSNRFVKNRRFHMNNTFYKGRTSTYFFEKCLTDGKERLSFLALPSLSIFGKEMYQSMAKSRRSFGIRLSYQNWVSKKLAKTKFFEKELTDQIKLLDTGSSFSKTMSRKTRLMGGKRRRIPRTYDPFVNNFRIRIPVSQTFLLEDDLGLSLWEWDKLATERKNRKAKKTVRINAIKDKIFTKDRRWKHGYGNPLPWEPLPSRSKRMFYFIFENRALYDYDLQNILKKIKSSPTLDVTWKEIMDLDYEDHILFLTYLEVGCCHRFGWISPLKAFLRKSSKSLSNVERRIRRLNKIGNLSMDLARYTILYFENNFDIPGGDGDFRYRKLRNVGITFAKGKPRSERLMKRYAKVSDFRRKFLKGSMRSRRRKTLLWKALQEKIRSSFFLRSAERTILFQSLIERLTTSSREEKFSELEKDTDYEFQKQLLDISLSAKRSLIGESKLTRSAIAARSDIGPIHNGRGYMLVFQSRFRKFIKLPVLIVLKNIGRILLRQNSEWNKDWTGWKKEIHINCTFDGEDFSQDELPPRWLREGIQIKIVYPFQLKPWHTDGNEKQHTLQRKHKEIGSKSRELKSKRKLKQKKHKFTYLTVLGYQTDIPFGTIQKKTSFWKPVRRKLIRICKRSLPRQIKQAYQFIHSRFEKVSKLNSTPSKKLNLISNLRQGGKLLSDYSLDEKSWMKTSSTNYVNEKTKPNCNVISNSERFIAIGGEMSPANVTRKQLVTRDQVEREFLMSIVAVDSKNLLDEKIDDPYSKITSKDLETGDTTSGDINLVNSTKFERKQLVDSEEAGLSLYLLVRELIETFVSVLINLPFTINRIFVHYFTEFLALYTKLAGILDNINEGSNLSTRSKSLQFDLPSQTCIYIDMWNIGMRGSLNLDLLVNDKRSSSNCGVKNRQSGIYVETDGVSNLYQPKMYEKQTPVHYNLIATKFLSPEIRNNHVNDLTMCFDTETGKTDEEFFDEKVARSIENWGFLNKSCKLDEINWNEWLYSLSRYNLPLTAWRNIAPRKWKVCLSELSSIETNTITELKDQVSQNKLHSYYSIYTKKSFLRNKISNFSKLRKHRNLLQNLTDSVQNGDVENLSVQRDIMEQRFHCKSCIQKSSRGGRNRISKFVHFLSSNVESKNNLNLQIDLLSWLDPDIAKTKIFLKKKKKAKQLKNPLLRNHYRYRYVLDISGRFQKVLNQLNDLTLDEREDADYIFRWKFKFETELEKFRNLISLTRMLGDDQDLITLCTNIEVNSDLLNLQFNAKTKRDMFHNLSVVSAHRLRLVFDDQDLLYKIINPLLKFKGRLRGIFRRRLYRNVYNGSYISNLSHILTERNCKQSCLYNIDDLLSPRRRREFRFLYCLLSPKIEYSQYISRIKKIDNAEKKQTLYHLPRPIRIQKIKRFLWPSHRLEEAACTGRSCVGVMTGSRFVTLRIRMYPIPLN
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Q85FG7
B6H3B2
VEA_PENRW
Velvet complex subunit A
Penicillium chrysogenum species complex
MANRPSLMPPHNETEHSVSRITREGKQLTYKLSVMQQPERARACGAGAKSSADRRPVDPPPVVELRIFESDPANDTQKTDITFAYNANFFLYATLETARPIAHGRVGGPQSCPVLTGVPVAGVAYLDRPSQAGYFIFPDLSVRHEGRYRLSFHLYEEIKDAKDADKDSTLPLPNQIPLSATSKPGIPQAFLHFRLEVKSVPFTVYSAKKFPGLATSTSLSRIIAEQGCRVRIRRDVRMRRRGDKRDEDYEFGEERAAAYARSSDRFTTPDRYAASMDRPRSNSNGSNIESPYGFVPPDRRPSAPDYGFQCPQPYQRPMPPAPMSHSQTPSYQSHLSFGSTPSHYPAPHMPPTPPPVAPQGIYSPQHAYAQIRHPSNGSEYEGTPIAYPAPQIPVERGGYPKPPMSSYAMDPPKPNSYMDPRMPEPSLYPSTPNVPVSRPQTPNLPAMPPPKPLSNDYANHVVPSVECTSPGGSGGGGYDNVRGKRMVYQTGPTYGKRSHEDTFGLDDRSMQNGMRPDTEPYPAYRDFSGESRAALMAEMGIQLSYKRANGKIVMKAPPSST
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination . The velvet complex acts as a global regulator for secondary metabolite gene expression . Controls the expression of the penicillin gene cluster . Positively controls the expression of the class V chitinase chiB1 . Positively controls the expression of the transcription factor atfA . Required for cell wall integrity and controls hyphal branching .
B6H3B2
P62017
VATD_SULTO
V-ATPase subunit D
Sulfurisphaera
MSSRKILPTKLNLINLRKQIRLTRTIKRLLENKREVLLIYLREYANEYEKLYSEVSQLLKEVYETYLMGVSAEGISTVESYANSVPPSLQVKSDLKVLFGVRIPIVKLDENSIQPQPFGDIEVSPYITKSRDAIAEAFKKILELVEMESAIRSLSTELRKTQRLINAIDSYILPYYTSSAKYIKGVLDDRTREEFVRLKMIRKVLQRRRGENVGNR
Produces ATP from ADP in the presence of a proton gradient across the membrane.
P62017
B0BSW9
TORD_ACTPJ
Chaperone protein TorD
Actinobacillus
MAHSQLLSSEERLFCYRWFHSLLAKELSEPQLQALQAGQFASFFAFLAELGFQPQVTDLQNELAKLTAYDSPRLELAADFAQCFLLEGKLSALPYASYYLDERDLSENLAVMDQWLTKFQLKINRLHNEPSDHLCIYLEVLIKLIETEQPVQVQQQFIRQQLLGWLPQWAEKTAQIHSSTAFYQIISNLLLGFLQQDIT
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
B0BSW9
P0DPW9
TX41A_SCODE
Toxin SSD219
Scolopendra
MKKTCVVSVFLVLLLLKFHDLSMGEEISPLKKVAPREQIFPCPGFPCPKGYFCDKGSQKCREGTD
Voltage-gated potassium channel inhibitor.
P0DPW9
Q8XAX1
YDEP_ECO57
Protein YdeP
Escherichia
MKKKIESYQGAAGGWGAVKSVANAVRKQMDIRQDVIAMFDMNKPEGFDCPGCAWPDPKHSASFDICENGAKAIAWEVTDKQVNASFFAQNTVQSLLTWGDHELEAAGRLTQPLKYDAVSDCYKPLSWQQAFDEIGARLQSYSDPNQVEFYTSGRTSNEAAFLYQLFAREYGSNNFPDCSNMCHEPTSVGLAASIGVGKGTVLLEDFEKCDLVICIGHNPGTNHPRMLTSLRALVKRGAKMIAINPLQERGLERFTAPQNPFEMLTNSETQLASAYYNVRIGGDMALLKGMMRLLIERDDAASAAGRPSLLDDEFIQTHTVGFDELRRDVLNSEWKDIERISGLSQTQIAELADAYAAAERTIICYGMGITQHEHGTQNVQQLVNLLLMKGNIGKPGAGICPLRGHSNVQGDRTVGITEKPSVEFLARLGERYGFTPPHVPGHAAIASMQAICTGQARALICMGGNFALAMPDREASAVPLTQLDLAVHVATKLNRSHLLTARHSYILPVLGRSEIDMQKSGAQAVTVEDSMSMIHASRGVLKPAGVMLKSECAVVAGIAQATLPQSVVAWEYLVEDYDRIRNDIEAVLPEFADYNQRIRHPGGFHLINAAAERRWMTPSGKANFITSKGLLEDPSSAFNSKLVMATVRSHDQYNTTIYGMDDRYRGVFGQRDVVFMSAKQAKICRVKNGERVNLIALTPDGKRSSRRMDRLKVVIYPMADRSLVTYFPESNHMLTLDNHDPLSGIPGYKSIPVELEPSN
Probably involved in acid resistance.
Q8XAX1
P63315
TNNC1_BOVIN
Troponin C, slow skeletal and cardiac muscles
Bos
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLEELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
P63315
B9VJ80
UBA5_BOMMO
Ubiquitin-like modifier-activating enzyme 5
Bombyx
MASVDELQKKIKELEAKLAAVEAKGGPMRQKIEVMSSEVVDSNPYSRLMALKRMGIVNNYEQIREKTVAVVGVGGVGSVTAEMLTRCGIGKLILFDYDKVELANMNRLFFQPHQAGLSKVDAAAATLQNINPDVTIDAYNYNITTVDNFQKFCDTISKGSLTGGAVDLVLSCVDNFEARMAINTACNELDQKWFESGVSENAVSGHIQFISPGESACFACAPPLVVATKVDERTLKREGVCAASLPTTMGIVAGFLVQNSLKYLLEFGNVTHYLGYSALTDFFPTMSLQPNPTCDDASCRARQEQRRLQPRVELAAEVTEDCGPVHQDNDWGISVLEENSPADEDCPGLKLVDGVQVAYSIPVDSSTPESSTGGAVAASELSLEDLMQQMKTM
E1-like enzyme which activates UFM1.
B9VJ80
Q7V2G1
TAL_PROMP
Transaldolase
Prochlorococcus
MKSILEQLSSITVVVADTGDLDAIKKFQPRDATTNPSLILAAAKNPDYIKLIDQALESSRKSLPAGFSESELIKETIDQVSVFFGKEILNLISGRVSTEVDARLSFDTEATVTKARKLINHYKSFGINKERILIKIASTWEGIKAAEILEKEGIKCNLTLLFNFCQAVACANAKITLISPFVGRILDWHKAKTGKDNFAGCEDPGVISVTKIYNYFKEKGFKTEVMGASFRNIDEIKELAGCDLLTIAPKFLDELNREEGELIKKLDEDTQSQSSIDYKFDEKDFRLSMLEDQMASEKLSEGITGFSKAIEELEELLLKRLSEINNQKLISTT
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Q7V2G1
Q9BSH4
TACO1_HUMAN
Translational activator of mitochondrially-encoded cytochrome c oxidase I
Homo
MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGARHSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
Q9BSH4
A4IJS3
UPPP_GEOTN
Undecaprenyl pyrophosphate phosphatase
Geobacillus
MDWMELLKAVILGMVEGLTEFAPVSSTGHMIIVDDLWLKSTEFLGKYAANTFKVVIQLGSILAAVVVFKDRFLELLGIRGRHPGGKPRLTLLHVIIGLLPAGVLGVLFEDYIDEHLFSTKTVLIGLVLGALLMIVADRFAKKAARAQTVDQITYKQAFLVGLVQCLSLWPGFSRSGSTIAGGVLVGMSHRAAADFTFIMAVPIMAGASGLSLLKNWQYVTVADIPFFIAGFLSAFVFALLAIRFFLHLINRIRLVPFAVYRIALAFIIYFLYF
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
A4IJS3
Q7X660
YSL11_ORYSJ
Protein YELLOW STRIPE LIKE 11
Oryza sativa
MASAAANNSSSAAYDAAETGGLLRRRNTTAAARGNAGEEEEEAEAVAPSVEQAFADKPVPSWREQLTVRAFVVGFLLSIMFNIIVMKLSLTTGVIPSLNVSASLLGFFLVRLWTAAIERVGFLKQPFTRQENTVIQTCVVSAYGVAFSGGFGSYLFGMSETIAKQATEANDPMNIKNPHLGWIIGFMFLVSFVGLFALVPMRKVMIVDYKLTYPSGTATAYLINGFHTPEGADLAKKQVRTLGKYFSISFLWAFFQWFYTAGDNCGFSSFPTFGLEAFKNRFYFDFSPTYVGVGMICPYIVNVSLLIGGIISWGIMWPLISKKKGSWYPETLPESSLLGLQAYKVFITIAVILGDGLYNFVKVFGYTIKGFIVMYKNKNSNTLPISDNGTPANATEEESFDDKRRNELFLKDQIPKTVAIGGYVVLAVITSGCLPLIIPQLKWYYILIAYIFAPIMAFCNAYGSGLTDWSLATTYGKLAIFVFGAWAGASHGGVLVGLAACGVMMNIVGTASDLMQDFKTGYMTLASPRSMFVSQVIGTAMGCVIAPCVFWLFYKSFNIGASDGAYPAPYTIMYRNMAILGVNGLSSLPKYCLTLCYIAFVAAFIINLIKDLVPERVAKYIPIPMAAAIPFYLGPYFAIDMFMGSVILYFWEWRNKDEAQSFGPAVASGLMCGDGLWALPQAVLSLVNVNPPLCMKFLSRAANAKVDTFLGN
May be involved in the transport of nicotianamine-chelated metals.
Q7X660
A5F7I4
YCIB_VIBC3
Inner membrane-spanning protein YciB
Vibrio
MKQLLDFIPLIIFFALYKFYDIYVATGALIAATTLQVIVTYAMYKKVEKMQLITFVMVALFGGMTLALHDDNFIKWKVTIVYVVFALGLTISQIMGKPAIKGMLGKELTLPDAVWSTINWAWVMFFSGCAALNLYVAYHLPLDVWVNFKVFGLLAATFVFTLLTGGYIYKHLPHEPKQKNQ
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
A5F7I4
Q1GR76
UPPP_SPHAL
Undecaprenyl pyrophosphate phosphatase
Sphingopyxis
MHDLATIILLGIIEGLTEFLPVSSTGHLILASEMLGFTGEGSAAFKIAIQLGAILAVLVAYRARFWGVGMGLLRADPAAVAFTRNILIGFLPAMLVGAVAYEGVRALLESPATVAVALLVGGIAILAIERMVKVVKVESVEAMPLRTAIAIGAVQCIAMIPGVSRSGATIMGALLMGVERRTAAEFSFFLAVPTMMGATAYSLWKDRAILTFDDMNAIAIGLFVAFLVALVVVKAFVAIVGRFGFAPFAWYRIIVGGGALLWLAWK
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q1GR76
Q7VRJ3
UBID_BLOFL
Polyprenyl p-hydroxybenzoate decarboxylase
Candidatus Blochmannia
MTYKDLRNFIKTLEYQGELKKIDFPVDPNLEITEIAHRTLKSQGPALLFTNPIGHSIPILCNLFGTISRIELGIGIKNILSLRDIGKLLAFLKEPQIPTGFRDFLSKIPNFRQILNMPIKHVSNAVCQENIWNNAQDIDITQMPIMKSWPGDISIAITWGITITQGFTNKRQNLGIYRHQVLSKNKIIIRWLAHRGGALDFQEWYTHSSEKKFPIAIALGADPATLIGAAIPIPNTLSEYAFSGLLRGSKTAVTKCISSNLYVPAYSEIILEGYINRDDIAVEGPFGDHTGYYNSTEKFPVCTITHITHRNNPIYHSTYTGRPPDEPSILGMAMNELFIPIIQKQFPEIIDFYLPPEGCSYRLAIVTIKKQFLGHAKKIIFGVWSCLNQFMYTKFILVCDDDINARDWKDVIWAISTRMDPARDIIIAENTPIDYLDFSSPISGLGSKMGIDATNKWPGETQRTWGKPIQMNNSIQSRINDIWDQLHIPCNEKPFKHKN
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Q7VRJ3
A2BTJ3
THIC_PROMS
Thiamine biosynthesis protein ThiC
Prochlorococcus
MRSSWIKPRLGKDNVTQMNFARNGYITEEMDFVAKKENLPSSLIMEEVARGRLIIPANINHLNLEPMSIGIASRCKVNANIGASPNASDINEEVEKLKLAVKYGADTVMDLSTGGVNLDEVRQAIIQESPVPIGTVPVYQALESVHGSIDRLTEDDFLHIIEKHCQQGVDYQTIHAGLLIEHLPKVKGRITGIVSRGGGILAQWMLHHFKQNPLYTRFDDICEIFKKYDCTFSLGDSLRPGCLHDASDDAQLAELKTLGELTRRAWEHNVQVMVEGPGHVPMDQIEFNVRKQMEECSEAPFYVLGPLVTDISPGYDHISSAIGAAMAGWYGTSMLCYVTPKEHLGLPNAEDVREGLIAYKIAAHAADIARHRAGARDRDDELSHARYNFDWNKQFELSLDPERAKQYHDETLPEEIFKKAEFCSMCGPKHCPMNSKISDESLDQLKDKLEECNTSV
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A2BTJ3
C5BB78
ZAPB_EDWI9
Cell division protein ZapB
Edwardsiella
MSFEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNQLNQEVQQAASNREGLLRENEQLKHEQEAWQERLRALLGKMNEVN
Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
C5BB78
Q2GS33
VPS27_CHAGB
Vacuolar protein sorting-associated protein 27
Chaetomium
MMGWWSSGANNALDEQIDKATSSSLEDIALNLEISDIIRSKTVQPKEAMRSLKKRINNKNPNTQLSALNLTDTCVKNGGAHFLAEIASREFMESLVSLLKAVGPGTVNAEVRAKILELIQSWATAAEGRYELGYIGEVYKTLQREGYQFPPRVTVASSMIDSNAPPEWVDSDVCMRCRTAFTFTNRKHHCRNCGNCFDQQCSTKSLPLPHLGILQAVRVDDGCYAKLTDKSSKASGAPPERSFTYSSSPAKPKGSSMQPRNARVDDGFDEDLKKALAMSLEEVKSHSRGYVSSPAANGVTSNQPKPNGHAAPKAVEEEDEDLKAAIAASLADMEEQKKQHAAALKQQASGAASSSSAAPSALPKNDYELTPLEAENINLFSTLVDRLQTQPPGTILREPQIQELYDSIGALRPKLARTYGETMSKHDTLLDLHARLSTVVRYYDRMLEERLSKAYSQHSIGGYNLPPPRQAPGPYPSLQPNAPPAAGPAENFYTGEQQQEYSHPTTHQPYPQPTLAQYGAYDKRGSVSAPSSNQYPPQQVPQHTGNWGPASSAQQYGQQPSYPPNEPPQTAQLQQTPNPAHLSAPAPAPNDSIGTTPTADPSASFYFSSQAQQQQQQQQQQQQQQQQQPQQVPSSPPDPNMSPYPNLAQPLHSYQPSLPQTPASIPAQPSQPQQAHQAPPQAQQPYWQHSAAQQTQLPPVWQPPPSAAYAGYTQESFPSAPHHAPKQPVVEESLIDL
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Q2GS33
O43280
TREA_HUMAN
Alpha,alpha-trehalose glucohydrolase
Homo
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTLPEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTPLWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTNGVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW
Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
O43280