accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q2L058
RL21_BORA1
50S ribosomal protein L21
Bordetella
MYAVVKTGGKQYRVAAGEKLKVEQIPADIGQEITLDQVLSVGEGDQLKVGTPLVAGAVVKATVLAHGRHDKVKIFKMRRRKHYQKRQGHRQNYTEIRIEAITA
This protein binds to 23S rRNA in the presence of protein L20.
Q2L058
P72656
RNE_SYNY3
Ribonuclease E/G
unclassified Synechocystis
MPKQIVIAEKHQVAAVFWKDQIQELVVSTGSQQVGDIYLGLVDNILPSIDAAFINIGDTEKNGFIHVSDLGPVRLRRTAGSISELLSPQQRVLVQVMKEPTGNKGPRLTGNISMPGRYMVLMPYGRGVNLSRRINREEERSRLRALAVLIKPPGMGLLVRTEAEDVPEDAIIEDLENLQKQWELVQQQAMTRSAPMLLDRDDDFIKRVLRDMYSSEVNRIVVDTPAGMKRIKQQLMNWDQGRLPEGVLIDCHRESLSILEYFRVNATIREALKPRVDLPSGGYIIIEPTEALTVIDVNSGSFTHSANSRETVLWTNYEAATEIARQLKLRNIGGVIIIDFIDMDSHKDQLQLLEHFNRCLETDKARPQIAQLTELGLVELTRKRQGQNLYELFGQPCPECGGLGHLVELPGEKGFVSLSPTAVNSSIPPRLVEKPILSPPVAKVNDLPKKEEAKISSPLDLLFHPNYQEQGDRDSNRRRRRRRGSEFSEKENIKSVGISRSKGPSPSPTKEKVTGTAPPRRERPSRRVEKTLVPVDVAMTTLEQDIYARMGISPLIKTEYADQDPRSFMVSVVTAGAALEGNTNGSGSLVNAVITTVDNGDNGDNVPSDGLTIVSEVTAPTPVIEQPREETVEPEQVVLPQLDDETPAAPVAEESAPIETKKRPGRRRRRSSAE
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Endogenous RNase E is required for correct processing of pre-crRNA for the CRISPR3 subtype III-B system in this genome (genes sll7080 to sll7095). This CRISPR3 system does not include a cas6 gene, which is the usual RNase involved in crRNA maturation.
P72656
Q9Z615
FENR_BUCAP
Flavodoxin--NADP reductase
Buchnera
MNPWINANVLKVHKWTQNLFSLILNAEIAPFQAGQFTKLALNEENINFSNNVKKKKIQRAYSFVNAPSNKNLEIYIVRILNGKLSNLLYNLKSGDNLFIKEKSFGFFTLDEIPNCKTLWMFATGTGIGPYCSILQEYKNINRFKNIILIHAVRYQNELTYLPLMKQLYKSYNGKLKIETIVSREKNHNSLYGRIPLLLQNQILEKKIGLKINRNDSHVMLCGNPAMVKDTYLFLQKDRCMQKNLRRKHGHITMENYW
Transports electrons between flavodoxin or ferredoxin and NADPH.
Q9Z615
B0UHX5
RPOC_METS4
Transcriptase subunit beta'
Methylobacterium
MNQEVMNLFNQQAQPQSFDQIKISISSPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGVICEKCGVEVTLARVRRDRMGHIELAAPVAHIWFLKSLPSRIGLLLDMALKDLERILYFESYVVIEPGLTPLKERQLLSEEEYLRAQEEYGEDSFTAMIGAEAIRRILQDLNLEKIAADLRQEIATTTSDLKPKKLLKRLKIIEAFQLSGNKPEWMILTVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPDIIIRNEKRMLQEAVDALFDNGRRGRVITGANKRPLKSLADMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYARLDAKGFSATVKQAKKLVEKEKPEVWDILDEVIREHPVMLNRAPTLHRLGIQAFEPKLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGAPIIVPSQDIVLGLYYLSIVADGAPGEYKSNNPLNPMQGVYGDFGELEHALASRAVTLHSKVKWRWKGLGPDGEEVTRTYDTTPGRVILSSVLPRHPKVPFDVVNKLMTKKEISAMIDTVYRHCGQKESVIFCDRIMGLGFSHAFKAGISFGKDDMVVPENKWTIVDETRALVKDYEQQYQDGLITQGEKYNKVVDAWAKCSDRLASEMMNRISSVQKDEKGADKQVNSIYMMSHSGARGSPAQMKQLAAMRGLMAKPSGEIIESPIISNFKEGLDVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDAVIREVDCGTDAGIRMRAIIDAGQVVATLATRILGRATAEDLVAQDGSIIVPKGQMIEERHLDAINKAGIQEVKIRSVLVCATKNGVCATCYGRDLARGTPVNQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAAQIADSSFIESSFEGTVRIRNRGLARNSDGDLIAIGRNVAVVIVGPDGTERAVHRLQYGARVRVDEGDSIKRGQRIAEWDPYTRPILTEVDGIVAYEDLIDGQSITETTDESTGIAKRVVIDWRGSARTADLRPALAIHDQNGKVLKLPRGSDARALLPVEAIIGVDPGARVKAGDILARVSTESAKTRDITGGLPRVAELFEARRPKDAAIIAEKSGTISFGRDYKNKRRLSLTPHDGSEPVEYLIPKGKHIHLQDGDVVEVGDFIVDGNPAPHDILAIKGVEELAAYLVNEIQEVYRLQGVSINDKHIEVIVRQMLQKVEITDSGDSEILTGDQIDRTELQEINEQLVSEGKKPVQGVPVLLGITKASLQTRSFISAASFQETTRVLTEAAVNGKVDTLEGLKENVIVGSLIPAGTGAMIADIKSIARRRDELIMAQKTAESGAALQELPAAE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B0UHX5
Q1QSR9
TRMB_CHRSD
tRNA(m7G46)-methyltransferase
Chromohalobacter
MSDSSSSSENAPATPESPGRPPRGIKSYVLRAGRMTAAQSRGLEEVWPRLGLSVAEGRQSLEALFGRRAPCVVEVGFGMGQSLVEQAAANPETDFIGIEVHAPGVGKLLDEADKRGLTNLRVYRDDALEVLDKCLPESSLTGLQLFFPDPWPKKKHHKRRIVQPAFVELVRTRLAPHGYLHMATDWEAYAEHMVEVMEEAPGYRNTAPPESAPYVPRPEFRPLTKFESRGERLGHGVWDLIYARVE
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q1QSR9
Q1QTJ9
HEM6_CHRSD
Oxygen-dependent coproporphyrinogen-III oxidase
Chromohalobacter
MAHPHLDKVKEYLLDLQDRLCDGLAAEEGDTAFREDSWTREAGGGGRSRVIENGEVFEKGGVNFSHVFGERLPASASAARPELAGRSFHAVGVSWVLHPRNPHVPTAHGNVRFFIAEKEGAEPVWWFGGGFDLTPFYPVFEDVVHWHRVAQETCAPFGDDVYPRFKRWCDEYFTLHHRDETRGVGGLFFDDLNEWEFERCFAFQRAVGDAFLEAYVPIVRRRQATEYGERERDFQAFRRGRYVEFNLVWDRGTLFGLQSGGRTESILMSMPPLAQWQYCWTPEPGSPEARLADEFLTPREWLEEAEA
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Q1QTJ9
Q48FA7
RIMO_PSE14
Ribosome maturation factor RimO
Pseudomonas
MSTVTTPSAPKVGFVSLGCPKALVDSERILTQLRMEGYEVVATYEDADVVVVNTCGFIDTAKAESLEVIGEAIKENGKVIVTGCMGVDANVIRDVHPSVLSVTGPQQYEQVVNAVHDVVPPRKDHNPLIDLVPPQGVKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGDVLDEAKRLVKSGVKELLVISQDTSAYGVDVKYRTGFWDGQPVKTRMTELCQALGSMGVWVRLHYVYPYPHVDELIPLMAAGKILPYLDIPFQHASPKILKLMKRPAFEDKTLARIKNWREQCPDLIIRSTFIVGFPGETEEDFQYLLDWLTEAQLDRVGCFQYSPVEGAPANLLDAAIVPDDVKQDRWDRFMAHQQAISAARLQMKIGKEIEVLIDEVDDRGAVGRCFFDAPEIDGNVFIGLEEGSTVQPGDKIMCRVTDADEYDLWAEML
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
Q48FA7
Q8ZTE6
NTPTH_PYRAE
Nucleoside triphosphate phosphohydrolase
Pyrobaculum
MTWRERAELRIGISGMPGVGKTTLVLKIAELARSRVKVCGFVTVEVREGGTRIGFDVVDLANGRRMALARVGRGEPSVGKYVVNLEACNVISEALRRECDLKIIDEIGAMEFKCKNFGEDLQTALHTSPRVIATVHRNYIDIAKKLGLEIIWLTRENWGLVFRQLLIQLGLTQ
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
Q8ZTE6
A4GGA7
RPOC2_PHAVU
Plastid-encoded RNA polymerase subunit beta''
Phaseolus
MAERTNLMFHNKVIGGTAIKRLISRLIDHFGMAYTSHILDQVKTLGFRQATATSISLGIDDLLTIPSKGWLVRDAEHQNLILEKQHHYGNVHAVEKLRQSIEIWYATSEYFRQEMNPNFRMTDPFNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVIRRTDCGTIRGISVNTQNEMMPESTWTQTLIGRVLADDIYRGSRCIAVRNQDIGIGLFNQFKTFQTQPISIRTPFTCRNTSWICRLCYGQSPTQGHLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEQVRAPYNGKIKFNEDLVHPTRTRHGHPAFLCYIDLYVSIENGDIIHNVTIPPKSFLLVQNNQYVKSEQVIAEILAGTYTFNFKEKVRKHVYSDLEGEMHWSTNVYHASEFKYSNVHILPKTSHLWILSGKSDRSGSVSFSTRKDQDQLNIHSLSTGERDICNHLASNNKIRHKLFHFNPSEKKERRISDYSIINQIICIDHCHFTHPAIFHDTTDLLAKRRRNRFIIPFQFQSIQERDKALMLASSISIEIPINGLFRRNSIFAYFDDPQYRTQSSGITKYRTIDINYILKKEDFVIEYPGVKEFKTKYQMKVDQFFFIPEEVYILPEFSSIMVRNNSIVEVDTPITVNIRSQVSGLVRLEKKKKKIQLKIFSGNIYFPGEMDKISRHSAMLIPPRTVKKNSKGSKKKMKNWIYAQWITITKKKYFVLVRPVILYEIADRIKLIKFFSQDMLQERDNLELQVINYILSGNGKSIRGISNTSIQLVRTCLVLNWDQDKKVSSIEKGHASFVELSINGLVRYFLKIALVKSHISYIRKRNDPSGSRFILDNESDWTNINPFFSMNSREKVQQSLSQNHGTIHMLLNRNDKCRSLIILSSSNCFQIRSFHDGKYYKEEMNPIQRDPLIPIKNSLGPLGIALQVANLDFYLLITHNQISINKNGQLDKLKETFQVFKYYLIDENERIYKPDISSNILLNPFYLNWHFFHHNSCEKKTFPIISLGQFICENVCIVQMKNAPHLKSGQILTVQMDSVGIRSANPYLATPGTTVHGHYGEILSEGDILVTFIYQKSRSGDITQGLPKVEQVLEVRSIDSISINLEKRVGTWNGRITRILGIPWGFFISAELTIAQSRISLVNQIQKVYRSQGVHIHNRHIEIIVRQITSKVLVSEDGMSNVFLPGELIGLLRAERAGRSLEESICYRVLLLGITKTSLNTQSFISEASFQETARVLSKAALRGRIDWLKGLKENVVLGGMMPVGTGFKRIIYRSKQRQYNKITSETKKRIDMIYQSNLGFKNS
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A4GGA7
E0ZS47
UREG_ORYSI
Urease accessory protein G
Oryza sativa
MASHDHDHHHHHHHSHDDGDHHHSHHQDGSHGGGGGSWVGEDGRVWHSHDGLAPHSHEPIYSPGDFSKRAPPLISRRFAERAFTVGIGGPVGTGKTALMLALCRSLREKYSLAAVTNDIFTKEDGEFLIKHGALPEERIRAVETGGCPHAAIREDISINLGPLEELSNLYKADLLLCESGGDNLAANFSRELADYIIYIIDVSGGDKIPRKGGPGITQADLLIINKTDLAPAVGADLAVMERDALRMREGGPFVFAQVKHGVGVEEIVNHILQAWEIATGNKRR
Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
E0ZS47
Q3M5D2
RS20_TRIV2
30S ribosomal protein S20
Trichormus
MCANNKSALKRAQIAERNRVRNKTYKSSVKTLMKNYLSAVQAYAANPTPESKQEAQTRLAAAYSRIDKAVKRGILHPNNGARKKSRLASKLKPIEQTA
Binds directly to 16S ribosomal RNA.
Q3M5D2
Q09013
DMPK_HUMAN
Myotonic dystrophy protein kinase
Homo
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Q09013
Q7NK24
CYSH_GLOVI
PAdoPS reductase
Gloeobacter
MNLLQDQPAMGIDQTTLEHLARQWEDLAPEAILAEAVRCFGDKLVLASAFGPESIILLDMLVKVWPRPQAFFLETGFHFPETLALKDRVLARFPQLQLEVVGPLMSVAQQNAIYGERLHDRNPDHCCAIRKVEPLNRALAPYKAWIAGMRREQSPTRGQIGVVQWDSRRGMVKFNPLATWTHKQVWAYIVERDLPYNPLHDEGFPSIGCSPLNCTAPVADGADPRSGRWRGKAKTECGLHA
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
Q7NK24
A9KNK1
UPPP_LACP7
Undecaprenyl pyrophosphate phosphatase
Lachnospiraceae
MDFIELLKVIFLGIVEGITEWLPISSTGHLLLVDEFLKVNLSKDFMSMFNVVIQLGAILAVVVLFFKKLWPFSKEEKNFIKKDTFTLWFKIVVACIPGIVMIPFDSKIEDLFFNPQTIATTLILYGILFIIIENRNAGKQPKVAKLSDITYQMAFMIGLFQILAMIPGTSRSGATIIGAMLFGASRYVAAEFTFFLAIPTMFGASLLKLLKFGFTFTGAEIVALITGMLTAFIVSIIVIKFLMGYIKKNNFKVFGWYRIVLGAIVAGYFLLAR
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
A9KNK1
P25066
P43_XENBO
Thesaurin-B
Xenopus
MQNVGPTEPSKSQVFRCPAAGCKAVYRKEGKLRDHMAGHSEQKLWKCGKKDCGKMFARKRQIQKHMKRHLTLKKHSCPTAGCKMTFSTKKSLSRHKLYKHGDAVPLKCSVPGCKRSFRKKRALRIHVSEHSNEPLSVCDVPGCGWKSTSAAKLAAHHRRHGGYRCSYEDCQTVSPTWTALQTHLKKHPLELQCAACKKPFKKASALRRHKATHAKNPLQLPCPRQDCDKIFSTVFNLTHHLRKVHLCLQTHRCPHSNCTRSFAMRESLVRHLVVHDPERKKLKLKFGRRPSKFLGRGTRCPTPVVEEDLSHLFSRKLLFHYKTRLETNLSGLFNERQLREPAEPEVNLSGLFQLPQGRPKAEKAA
p43 is a 5S RNA binding protein which is a major constituent of oocytes and comprises part of a 42S ribonucleoprotein storage particle.
P25066
Q3MAP6
Y2322_TRIV2
Nucleoid-associated protein Ava_2322
Trichormus
MTGKGQGFGFGLGKMKELAEAFKKAQQVQEGAKRLQEELEQMEILGEAGGGLVKVIVSGNQEPKRVEISPDALAQGADLLSDLVTAAMKDAYIKSTATMRERMEDLTSGLELPGF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q3MAP6
Q9H6K4
OPA3_HUMAN
Optic atrophy 3 protein
Homo
MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRTKMRIMGFRGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEVGHLALALEALQAQVQAAPPQGALEELRTELQEVRAQLCNPGRSASHAVPASKK
May play some role in mitochondrial processes.
Q9H6K4
O57776
FTSZ1_PYRHO
Cell division protein FtsZ 1
Pyrococcus
MLKLVENVVERVSSEETKVQEVQVPQSSIDEELKKIVEQIKARIHVVGVGGAGCNTVNRMMEVGVTGAKIIAVNTDAQDLLKVKAHQKILIGKEITRGLGAGNDPKIGEEAAKESEREIREALEGADMVFVTCGLGGGTGTGAAPVIAEMARKMGALTVSVVTLPFTMEGIRRAKNAEYGLKRLAKASDTVIVIPNDKLLEVAPKLPIQMAFKVADEILVQAVKGITELITKPGLVNLDFNDVRAVMKDGGVAMIGIGESDSEKRALEAAEQALNSPLLDVDISGAKGALISISGADVKLEEAQQIIEYVTRNVDPKAQVIWGIQLEPELEKTIRVMVIVTGITSRYVTFQEETPAPSEEETTPVKIDIPEL
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
O57776
Q576B4
NU5M_BOSIN
NADH dehydrogenase subunit 5
Bos
MNMFSSLSLVTLLLLTMPIMMMSLNTYKPSNYPLYVKTAISYAFITSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFTPVALFVTWSIMEFSMWYMHSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAVLYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKFIQSITLCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAANTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVSINENNPLLINSIKRLLIGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPSNAFKFSTLLGYFPTIMHRLAPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTLVTNQKGLIKLYFLSFLITILISMMLFNFHE
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q576B4
A3Q192
PSA_MYCSJ
Proteasome core protein PrcA
unclassified Mycobacterium
MSFPYFISPEQAMRERSELARKGIARGRSVVALAYADGVLFVAENPSRSLQKVSELYDRVGFAAVGRFNEFNNLRSGGIRFADTQGYAYSRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHFGESKAPELYRITYDGSIADEPHFVVMGGATEPIIAKLNDSYTENAELADAVRIAVDALESGGNGAERRTLGPSTLEVAILDANRPRRAFRRITGSALEALLPQRDAEASADAGAADKPAE
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
A3Q192
Q87TS0
YIDD_PSESM
Putative membrane protein insertion efficiency factor
Pseudomonas
MRKLALVPIQFYRYAISPLMASHCRFYPSCSCYAYEAIDNHGLLRGGWLSIRRLGRCHPWNPGGYDPVPAVPTSRSSSMAE
Could be involved in insertion of integral membrane proteins into the membrane.
Q87TS0
P23572
CDK1_DROME
p34 protein kinase
Sophophora
MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN
Plays a key role in the control of the eukaryotic cell cycle . It is required in higher cells for entry into S-phase and mitosis . In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition . p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II .
P23572
Q7LYX6
MALG_THELN
Trehalose/maltose transport system permease protein MalG
Thermococcus
MREEVLKRILLIIGAILMAIICLFPFIWMIVVSFAEDPTFLGSPLVEYKSTLENYVRVLSDPTLHFPAYLKNSIIIASLVTLTTVSISSLAAYAVSRIEFKGRLLIPIFVLGLSMFPQISLVGYLFKFIEKLGWVNTYQALYFPYVAWTLPLSLWILLSYFSQLPKDLDEAAMIDGASRIKTLTTIILPLSAPALFSTALLVFIAAFNEFMFALLFTTDHRARTVPVGIALFQGVHGEIPWGSVMAASVISTIPLVIMALLFQKYIVSGLTAGALKGE
Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane.
Q7LYX6
Q39085
DIM_ARATH
Protein ENHANCED VERY-LOW-FLUENCE RESPONSE 1
Arabidopsis
MSDLQTPLVRPKRKKTWVDYFVKFRWIIVIFIVLPFSATFYFLIYLGDMWSESKSFEKRQKEHDENVKKVIKRLKGRDASKDGLVCTARKPWIAVGMRNVDYKRARHFEVDLGEFRNILEINKEKMTARVEPLVNMGQISRATVPMNLSLAVVAELDDLTVGGLINGYGIEGSSHIYGLFADTVEAYEIVLAGGELVRATRDNEYSDLYYAIPWSQGTLGLLVAAEIRLIKVKEYMRLTYIPVKGDLQALAQGYIDSFAPKDGDKSKIPDFVEGMVYNPTEGVMMVGTYASKEEAKKKGNKINNVGWWFKPWFYQHAQTALKKGQFVEYIPTREYYHRHTRCLYWEGKLILPFGDQFWFRYLLGWLMPPKVSLLKATQGEAIRNYYHDMHVIQDMLVPLYKVGDALEWVHREMEVYPIWLCPHKLFKQPIKGQIYPEPGFEYENRQGDTEDAQMYTDVGVYYAPGCVLRGEEFDGSEAVRRMEKWLIENHGFQPQYAVSELDEKSFWRMFNGELYEECRKKYRAIGTFMSVYYKSKKGRKTEKEVREAEQAHLETAYAEAD
Plays a critical role in the general process of plant cell elongation. Involved in the synthesis of campesterol, an early precursor of brassinolide. Required for the conversion of 24-methylenecholesterol to campesterol and for the conversion of isofucosterol to sitosterol. Necessary for both the isomerization and reduction of 24-methylenecholesterol. Regulates indirectly phytochrome-mediated light responses through the modulation of brassinosteroid biosynthesis.
Q39085
A0T0L2
PSAC_PHATC
PsaC
Phaeodactylum
MSHTVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKAGQIASSPRVEDCVGCKRCETACPTDFLSVRVYLGAETTRSLGLAY
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
A0T0L2
Q1JS90
RN2VB_ODOVE
2VEb
Odorrana
MFTLKKSFLLLFFLGTITLSLCEEERGADDDDGEEEVKRGIMDTVKGVAKTVAASLLDKLKCKITGC
Antimicrobial peptide.
Q1JS90
Q980F0
MOAA_SACS2
Molybdenum cofactor biosynthesis protein A
Saccharolobus
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVKLTGGEPTLRRDLVEIVRGLKQLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSRDTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRNREEAFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYANPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIREPNFKYKI
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Q980F0
Q5QYI0
RPOZ_IDILO
Transcriptase subunit omega
Idiomarina
MARVTVEDAVDRVGNRFDLILLASRRARQLANGKEPLVETKNEKPTVIALREIEQGLIDNERLDIEDQAAQKQQDAEELRAVDALRGIE
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Q5QYI0
Q10357
CCS1_SCHPO
Superoxide dismutase 1 copper chaperone
Schizosaccharomyces
MFEVEYLIKDCDDVNKNTLEQEFQDLNIEDWKWDAATGQLIVKGSVSPSKVLRRLENATSKPILIRGASNKESGVSILYEANEDITQIPKVYGLCRFIPTEEKIFLDLIATQLLPNREYTGLVTISGDISRGLKSAGDSLVTLFNANSNEQGKIVLDKEVSGSLPNWIGHCFVLKCVDDSDSATMGIISRSAGLGQNTKQICACTGKSLWTEHAELKSVNEGSSCCSKKDSSPSEKPSCCSQEKKSCCSSKKPSCCSQEKKGCCSTEKTSCCSQEKKSCCTSEKPSCCSNGKSTVCA
Copper chaperone for superoxide dismutase 1 (sod1). Binds copper ions and delivers them specifically to sod1. Also has a role in cell protection against copper ion toxicity during conditions of copper excess. The C-terminal region is thought to act specifically in this sequestration role.
Q10357
Q30S45
EFP_SULDN
Elongation factor P
Sulfurimonas
MATIGMGDIKKNIRLIIGEVPCKVIEFQHVKPGKGAAFVRMKAKSFLNGRVFEKTVHAGDKFEVPEITFKTMQYLYDDGEQYQFMDNDSYEQIGLSYEQCDDASKWFKDGIQVDMIFYKGNAISVSAPEVMELLITDTPPNFKGDTSSGSKKPATLETGAVVQVPYHVLEGDTIRVNTVDCEYLEKVK
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Q30S45
Q8RGC8
FBPC_FUSNN
Fe(3+) ions import ATP-binding protein FbpC
Fusobacterium
MSVNIKIENAQKRYGDNIIIENLSLDIKQGEFFTLLGPSGCGKTTLLRMIAGFNSIEKGNFYFNEKRINDLDPAKRNIGMVFQNYAIFPHLTVEQNVEFGLKNRKVSKEEMKIEIDKFLKLMQIDEYKDRMPERLSGGQQQRVALARALVIKPDVLLMDEPLSNLDAKLRVEMRTAIKEIQNSIGITTVYVTHDQEEAMAVSDRIAVMKDGEIQHLGQPKDIYQRPANLFVATFIGKTNVLKGNLNGSILKVAGKYEVSLNNIKDKNIKGNVVISIRPEEFVIDENQTKDGMRAFIDSSVFLGLNTHYFAHLESGEKIEIVQESKIDSIIPKGAEVYLKVKQDKINVFTEDGSRNILEGVNNDAIGVAYVK
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
Q8RGC8
A5FS53
ISPE_DEHMB
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Dehalococcoides
MLTLLAPAKVNLSLEVLYRRKDGYHELRSIIQSLSLCDRLSFSPSKTVHISSDSQDWQADLSLVSKAVELFSERCGQNTGVNLKIAKRIPLVSGLGGDSSCAAAVLKGLNKLWGCGYPCWRLMEIGAELGSDVPFFIMGGTAMMEGRGETVTPLPTLTQMWAVLLVPALDMPADKTAALYRNLRPDSFTSGEISDKLLESICQGKLSLSLCFNAFEKVAFELFPELVKYRWQFLEAGAYQISLAGAGPTLFTLLKDKNTAEKIYHNLCQKGHQAYLVSTLGPLD
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
A5FS53
Q1GCN5
HSLV_RUEST
ATP-dependent protease subunit HslV
unclassified Ruegeria
MAEDQFPGWHGTTIIGVRKGDEVVVAGDGQVSLGQTVIKGSARKVRRLSPGGYDVVAGFAGSTADAFTLLERLEAKLEATPGQLQRASVELAKDWRTDKYLQKLEAMLIVTDGKDLYVITGAGDVLEPEHDVAAIGSGGNFALAAARGMMDSDRDAETVARDAMAIASDICVYTNGNLTVERIGK
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
Q1GCN5
Q9ZDY3
ODO1_RICPR
Alpha-ketoglutarate dehydrogenase
typhus group
MEEYFNKTGYLFSGNAVFVEELYRQYLANPNSVDQTWQEFFADIKDNNVVLNKSTAKVISTNVTNKELLNNNLSSETLNNLKAKEMISAYRRNAHYLANLDPLGLEIRKTKNDLKLNIEAFGLDSSQLGENINIMDEFIGTWNCKLSELVTKLDKVYTSSIGVEFDQIENVEEKNWLYTKLETDITFTSEEKKSILNDLVEVECFEQFLHIKFPGAKRFSIEGGDASIVAMNKAIDLSMHQGVEEIVIGMAHRGRLNTLTKVVGKPYKEVIASFINGNIFPDGLNVSGDVKYHLGYSADRVRANQKIHLSLADNPSHLEAINSIVAGKVRAKQDIFVDTKRSKIKAILVHGDAAFCGQGVVAESLSMSPLTAYNVGGILHFVINNQLGFTANAADTRASRYSTEFAKIISAPILHVNGDDIEAVLKATDIAVEYRQKFSKDVVVEIICYRKYGHNEGDEPMYTQSKMYNIIKSKPTPGSIYANELVKNGIIDNNYYAKLKEKFKIRLDQEYEQAKSYKQETHFFEGYWKGISRIRGKDAITGVNKKILQDLGTKLCEIPKDFAINPKLIRLFEVRKTTLTTDQPIDWATAEQLAFAHLLCSGINIRLTGQDSARGTFSHRHSILHNQIDDTTYIPLNNLSKTQAKYEVANSNLSEYAALGFEYGYSLANPKNLVLWEAQFGDFANGAQIIFDQFISSSATKWLRMSGLVVLLPHAFEGQGPEHSSARLERFLQLAAEENMYITYPTTPASIFHLLRRQILESTRKPLIVMSPKSLLRHKYAVSKLDELGENTTFIPILDEVTKIDTNNVTKVILCSGKVYYDLFAMRTNNSNIVIIRLEQLYPFEKKLVASLLKKYNKAQAFIWCQEEPKNMGAWHYIATHLNDALKEAEINNEFKYVGREESASPAVGSLQVHNKQQEKLLMEALGDDIIKEKLY
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Q9ZDY3
P53869
MRX7_YEAST
Mitochondrial organization of gene expression protein 7
Saccharomyces
MPPRSIEEWFYYKLLSSPGFHRFVRKVYRKVNGIKEDPFTDQSTAFQYLYKPTPRQKFKALRLLFWDEMRSTFGFRRRLGDRFKKD
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
P53869
Q0TLZ4
MNME_CLOP1
tRNA modification GTPase MnmE
Clostridium
MKEFDTIAAIATALGEGGIAIIRVSGNKALEIVNKIFRGINGKDLLDIKPYTMRYGHMIDENNEIIDEVIVSFMKGPRSFTAEDTVEINCHGGIVATNKVLQNVIKAGARLAEPGEFTKRAFLNGRIDLSQAEAVMDIITAKTELSMKSAMTQSQGRLSTEINNLRKEALDILALIEYAVDFTEDDEEPDETIPVKVKEDVITLRGKVNNLIDTADEGKLIRDGLSMVIVGKPNVGKSSLLNALLNEKRAIVTDIAGTTRDVIEEYINLDGIPVRLVDTAGIRETEDVVEKIGVEKSKEKINEADLVILMLDTSRELDEEDKEIIDYIKDRKYIVLLNKVDLDRKLSSEIVDNLENKIELSAKTGFGIDDLKSKIKDLFFNGSIDAESVMVTNTRHKEALYRASENLDGALNGLNNNEFLDLVSIYVTSALRALGEITGAELEEDLVNKIFAEFCCGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q0TLZ4
A0KU20
TORD_SHESA
Chaperone protein TorD
Shewanella
MSNVDINHARALVYQLLSSLFAREIDEQRLKQLTSEQAQQFWTQLGYAPEFSASVASIQKVLNGLTSDEALLELAADYCGLFLVGTKHSASPYASLYLNREEEPLLFGQQHQQMSEFLHQSKLQVQSHFPEPADHLAVILAYMGHLACHSEDAAQLSFLNACIDSWLAKFVAKVVECDSKHSNGFYSALATLTLAWVQQDKQQLEQAMH
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
A0KU20
Q9F6B2
SLYA_EDWTA
Edwardsiella hemolysin activator
Edwardsiella
MESTLGSDLSRLVRVWRALIDQRLKPLELTQTHWVTLYNIHRLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLITRHICANDRRAKRIKLTDDAEPVIKEVTGVISLTRSEILDGISTDEIALLTNLVERLEQNIIHLQNK
Transcription regulator that can specifically activate or repress expression of target genes.
Q9F6B2
A4SG06
GCSPA_CHLPM
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Chlorobium
MPFIINTDSDRAEMLAAAGAASFNDLIADIPEEIRLKKSLDLAPALDEMAVRRQLESLAARNRSTAGYVSFLGGGAYDQFIPSAIRAIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLICRLYGMDVANASMYDGATALAEAALMAMNVTGKERIVVAGQLHPWNSSVLSTYLGAAGHSPVVQNSVEEGVGSIASLRGMVDGTVAAVIVQQPNFYGCLEDVEAIGAIAREAGALFIVSADPHSLGVLEAPGAYGADIAVGEGQPLGSAQSFGGPYLGIFTVREKFVRKIPGRLVGMTKDRDGRDGFILTLQTREQHIRREKATSNICTNQALNALQAAVYLSLLGRQGMQEVAGQSLERAHYLAARIVEIPGYSLRFSAPFFREFVLNTPVHPAVIVERMLEEGIFAGIDLSVFGDEGLLVSVTEKRTKEEMDRFALLLSSF
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
A4SG06
Q5PN95
SOTB_SALPA
Probable sugar efflux transporter
Salmonella
MTINPVSRKVAWLRVVTLAIAAFIFNTTEFVPVGLLSDIAESFHMQTAQVGIMLTIYAWVVAVMSLPFMLLTSQMERRKLLICLFVLFIASHVLSFLAWNFTVLVISRIGIAFAHAIFWSITASLAIRLAPAGKRAQALSLIATGTALAMVLGLPIGRVVGQYFGWRTTFFAIGMGALITLLCLIKLLPKLPSEHSGSLKSLPLLFRCPALMSLYVLTVVVVTAHYTAYSYIEPFVQNVAGLSANFATVLLLLLGGAGIIGSLVFGKLGNRHASSLVSIAIALLVVCLLLLLPAADSEAHLAILSIFWGIAIMVIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSAIGYIGAIPACAALVWAVLIFRKWPVTLEEQPH
Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
Q5PN95
C6BYG6
MURG_MARSD
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Maridesulfovibrio
MKRIVLTTGGTGGHVFPALAVAHEIKNRFPQCEILFIGGKGPEREMVERAGISFKGLPAKGVLGGGIKKVFSSLWIVSAMIMALKEIASFKPDAVIGFGGYAGFCPVLAAWLLGVPTAIHEQNSVPGVTNRILGKVVKRVFASFEDRNGSFPAAKTVVVGNPVRKEIIDSGNCADTKTVLVFGGSQGAAAINDAVIDGLAKLKEAGISLRHQTGKADFEKVRKGYEQNGMDTGKVSPFIHNMGEAYAEASLVVCRAGASTVFEVAAAGKPAIFIPFPHATHDHQTGNARSLADLGAAELIPQAELGGNRLADEIIKLIADQDRLKGMGSKALSFARTDAASAIAEGVGDIIRMKTVRGAA
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
C6BYG6
B1ZNE4
RS19_OPITP
30S ribosomal protein S19
Opitutus
MSRSIKKGFFVDYHLLEKIEKANKAGAKKPIQTWSRRSTITPDFVGHTFSVHNGKAFIAVYVTENMVGHKLGEFALTRIFKAHGGMTRKEI
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
B1ZNE4
Q7Z417
NUFP2_HUMAN
Nuclear FMR1-interacting protein 2
Homo
MEEKPGQPQPQHHHSHHHPHHHPQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGELNGNAGEREISLKNLSSDEATNPISRVLNGNQQVVDTSLKQTVKANTFGKAGIKTKNFIQKNSMDKKNGKSYENKSGENQSVDKSDTIPIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNIVQDKIMQQETSVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDMLRKSSDSKPGVSSKKFDDRPKGKHASAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTIQNSSVSPTSSSSSSSSTGETQTQSSSRLSQVPMSALKSVTSANFSNGPVLAGTDGNVYPPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKTSLFIYPSNMQTMLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSEHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTSESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEIESQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESIWNLQKQDPKRIITYNEAMDSPDQ
Binds RNA.
Q7Z417
A2BPT4
CH601_PROMS
Chaperonin-60 1
Prochlorococcus
MAKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIEIENPIANLGAKLIEQVASKTKESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGMEAGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSIISKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQKAGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDKVSINDLGKAKKITITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEISDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSGQYEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
A2BPT4
A7MGV2
NDK_CROS8
Nucleoside-2-P kinase
Cronobacter
MAIERTFSIIKPNAVAKNVIGSIFARFESAGFKIIGTKMLHLTVEQARGFYAEHEGKPFFDGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSDSVESANREIAYFFGEGEICPRTR
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
A7MGV2
P92671
CYB_OSPRO
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Osphranter
MTNLRKSHPLIKIVNHSFIDLPAPSNISAWWNFGSLLGACLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYVGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDALGLMLMLFILLMLALFSPDMLGDPDNFSPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTSKQRSLMFRPISQTLFWILTANLITLTWIGGQPVEQPFIIIGQLASISYFLLIIILMPLAGLFENYMLEPKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
P92671
Q9UTP3
FTA6_SCHPO
Sim4-mal2-associated protein 6
Schizosaccharomyces
MEDKYILLSAVETFKSRLEELLMQSAKVQKQTMLRKELASSMNDMASTVQEALNKKKSS
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Q9UTP3
Q9PGI7
NUOI_XYLFA
NDH-1 subunit I
Xylella
MMNRVMHYFKSLLLLELLAGLWLTLKYTFRPKYTVLYPMEKFPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITIDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVETHILEYHFEKRGENIVTKPQLLAIGDRFEAEIAERRAADAAFR
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q9PGI7
Q49YB7
NRDR_STAS1
Transcriptional repressor NrdR
Staphylococcus
MKCPKCNSTHSRVVDSRHADEVNAIRRRRECEECETRFTTFEHIEKRPLIVVKKDGTREQFLREKILNGLVRSCEKRPVRYEQLEDITNNVEWKLRDEGRAEISSREIGEHVMNLLMHVDQVSYVRFASVYKEFKDVDQLLQSMQGILAENKRSDS
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Q49YB7
A5FRX9
RS19_DEHMB
30S ribosomal protein S19
Dehalococcoides
MSRSVKKGPALCPKLMKKVEVASATNQKSIIKTWARWSTITPLMVGLNVGVHDGRRHVPIYITENMVGHKLGEFTTTRNFRGHAKAEKVSQVK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
A5FRX9
O88508
DNM3A_MOUSE
DNA methyltransferase MmuIIIA
Mus
MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESSDTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development . DNA methylation is coordinated with methylation of histones . It modifies DNA in a non-processive manner and also methylates non-CpG sites . May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 . Plays a role in paternal and maternal imprinting . Required for methylation of most imprinted loci in germ cells . Acts as a transcriptional corepressor for ZBTB18 . Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites . Can actively repress transcription through the recruitment of HDAC activity . Also has weak auto-methylation activity on Cys-706 in absence of DNA .
O88508
C0ZY16
EFTS_RHOE4
Elongation factor Ts
Rhodococcus erythropolis group
MANYTAADVKRLRELTGSGMMACKNALADADGDFDKAVEQLRIKGAKDVGKRAERTTAEGLVVAKDGVMIEINCETDFVAKNDEFIKLADEIVTVAAAGKPADLDALKALELDGKTIDTVIAEQSAKIGEKLELSRVASFDGPVAVYLHKRSSDLPPAVGVLIEYTGEGDAAAEAARGAAMQVAALKAKYVTRDEVPAEIVASERHIAEETARAEGKPEQALPKIIEGRVNGFFKDVVLTEQSSVTDSKKTVKAILDEAGVTIKRFVRFEVGASA
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
C0ZY16
A3N2P2
LIPB_ACTP2
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Actinobacillus
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPTNIPVVQTDRGGQITYHGEGQQVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYGIEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVNMDLTPFRNINPCGYAGLEMTQLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
A3N2P2
I1S163
FSL4_GIBZE
Fusarielin biosynthesis cluster protein 4
Fusarium
MSVIGLWLVTVTATLSLFVWQLIFLLSIPKSIVVCLIAESLFFVAWFFYWTVIYPRYLTPFRHLPTPASRSILTGNQNGLFTENSWDVARRVSQTVPNSGLIRYYVALSNERILVTNTRALSDVLTNHSHDFGKSNLAKFALKRLTGNGLGFLEGNEHKVHRKNLMPAFTRKHVKELTPIFWDKAMEMVKGMEAEVRCGKDTSTQGTGIVEIHDWATRATLDIIGTAGFGYDFGTLHNPSNEIGQQYKKMFLEPSTAFNWLELLGNYIDFRFLMTLPVKKNRDLTAGSNFMREIAKKVIRERRHELFQRMTSQAGNMKNTKKDIITTALASDCFTDDQLVDHVMAFLVAGHESTATAFEWAMYELGHRPEMQKRVRDEVRTYLPSPSAGGVKNITFESVPYLQAICNEVLRLYPFLPFATRVAEKDTWVADQFVPKGTIVAYAAHISNRDSELWSGPALDAFDPERWMEPGKESSGGANSNYAMLTFSAGPKSCIGEAWTRAELPCLVGAMVGSFEIELVEGKQADGTVYPTVDFKMGKVLKSRDGVFVRLRRLEDW
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism .
I1S163
B5ZSI4
AROB_RHILW
3-dehydroquinate synthase
Rhizobium
MNAIPSASSVQTVHVPLGERAYDILIGPGLIARAGAEIASRLKGRKAAVVTDENVAPLYLQALVASLDEAGIASAAVVLPAGEKTKSFEHLMTACDKVLEARVERNDCVIALGGGVIGDLSGFAAGIVRRGVRFVQVPTSLLAQVDSSVGGKTGINSRHGKNLIGVFHQPDLVLADTDVLNTLSEREFRAGYAEVAKYGLIDKPDFFAWLEANWKAVFTGGAARIEAIAASCQAKADVVVADERENGPRALLNLGHTFGHALETATAYDSSRLVHGEGVSIGMVLAHEFSARMNLASPDDARRVERHLQEVGLPTRMSDIPGALPPAETLMDAIAQDKKVKSGKLTFILTRGIGQSFVADDVPASEVISFLREKHP
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
B5ZSI4
A4JGH4
UPP_BURVG
UPRTase
Burkholderia cepacia complex
MKQDSRFPNLFILDHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPITTRRVATPLVEVDAPVIAGKKLAIVPVLRAGIGMSDGLLDLVPSARVGHIGVYRADDHRPVEYLVRLPDLEDRVFILCDPMVATGYSAVHAVDVLKRRNVPAANIVFVALVAAPEGVQVFQDAHPDVKLYVASLDSHLNEHAYIVPGLGDAGDRLFGTKN
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
A4JGH4
Q87BT4
TYSY_XYLFT
Thymidylate synthase
Xylella
MKQYLELLNDVLVHGIKKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWFLRGETNIAYLKKHQVHIWDEWADATGELGPVYGKQWRRWAGADGHEIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMALVPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLVVGDFVHTLGDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q87BT4
P48038
ACRO_RABIT
Acrosin heavy chain
Oryctolagus
MLPTAVLLVLVVSVVAKDNATCDGPCGLRFRQNPQGGFRVVGGQAAQQGAWPWMVSLQIFTPRNNRRYHACGGVLLNAHWVLTAAHCFNNKQKVYEWRMVFGAQEIEYGTDKPVRPPLQERYVEKVVTHDQYNYMTEGNDIALLKITPPVPCGPFIGPGCLPNSKAGPPKAAQTCYVAGWGYVKENAPRPSPTLMEARVDLINLELCNSTQWYNGRITASNLCAGYPSGKIDTCQGDSGGPLMCRENQGEPFVVQGITSWGVGCARAKRPGIYTATWPFLDWIASRIGSNALRMIQPATPTPPTTRSPGVHQPPSAHPPWYFQHASGPPHPHPHPHPHPHPRPPQPPAAQAPPPPPPPPPPPPPPPPPPPPPPPPPPPASTKPPQALSFAKRLQQLVEVLKGGSTFSGAKRVDTAAAAAEATEIPEVTLAS
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
P48038
Q6F992
RUVA_ACIAD
Holliday junction ATP-dependent DNA helicase RuvA
Acinetobacter
MIGCLIGEVFALEAPTVLLNVNGVGYEIDTPLSTFCQLQKGQHVTLWTHLVVREDAQQLYGFIDAQEKLIFRTLLKVNGVGPKMALGILSTLSIELFIHTIEHDDINTLIKVPGVGRKTAERLMIELRDRFKALSVQATTGSTVTSAQIQFSSNSPIAEAEAALQSLGYKPIEAQKAIAAVKADYTEAADLIRAALKSMMK
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
Q6F992
Q9AVE3
SCRA_ARALY
S locus cysteine-rich-like protein a
Arabidopsis
MRCSVLFVVSYVIMSLLISHVQGMEDQKWKKVCNLEGNFPGRCVGNGDEQCKRDLTEDGNNPSKCRCRFRAGRRHCRCIYCEVFGM
Involved in self-incompatibility.
Q9AVE3
Q8UJ43
Y095_AGRFC
Nucleoid-associated protein Atu0095
Agrobacterium tumefaciens complex
MRDIMGMMGKVKEMQSKMEKVQQEIAALEIEGRAGGGLVTVILNGKGEMRGLKIDPSLFKEDEVEILEDLIVAAHKDAKEKGEAQAQEKMADLTAGLPLPPGMKLPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q8UJ43
Q30P06
ENO_SULDN
2-phosphoglycerate dehydratase
Sulfurimonas
MFIDNVSAIEVMDSRGNPTVKTTVELSDGTKESAIVPSGASTGKREALELRDGGSRYMGKGVLKAVENVNAQISDALIGLSPFNQAVIDATMKELDGTDNYGNLGANAVLGVSMAVARAAAKSLGIPLYRYLGGANAMVIPTPMLNIINGGSHADNSVDFQEYMIMPVGFEDFATSLQASAEVYHNLKAILKSKKHNTALGDEGGFAPDLSSNEEPIQIIMQAIEKAGYKAGEQMAIALDVAASELVSDGGYRLDSENRTVTSAELVDYYVDLCNKYPIVSIEDGLSEDDWDGWKLLTEKLGDRVQLVGDDLFVTNATILNEGIKKGIANSILIKPNQIGSVSETMQTVRLAQRNGYKCVMSHRSGESEDAFIADFAVALNCGEIKTGSTARGERTAKYNRLLEIENEVVYGEYLGSELFN
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Q30P06
Q9LMU0
FCL2_ARATH
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase 2
Arabidopsis
MADNTGSEMKSGSFMLEKSAKIFVAGHRGLVGSAIVRKLQDQGFTNLVLRTHSELDLTSQSDVESFFATEKPVYVILAAAKVGGIHANNTYPADFIGVNLQIQTNVIHSAYTHGVKKLLFLGSSCIYPKFAPQPIPESALLTGPLEPTNEWYAIAKIAGIKMCQAYRLQHQWDAISGMPTNLYGQNDNFHPENSHVLPALMRRFHEAKANNADEVVVWGSGSPLREFLHVDDLADACVFLMDQYSGFEHVNVGSGVEVTIKELAELVKEVVGFKGKLVWDTTKPDGTPRKLMDSSKLASLGWTPKISLKDGLSQTYEWYLENVVQKKQ
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Q9LMU0
B9MIA2
MNMA_ACIET
tRNA-specific 2-thiouridylase MnmA
Diaphorobacter
MTKHRVVVGLSGGVDSAVTAHLLKQQGHEVVGIFMKNWEDDDDSEFCSSRQDFLDAASVADVIGIEIEHVNFAAEYKDRVFAEFLREYQAGRTPNPDVLCNAEIKFKAFLDHAMRLGAEKIATGHYARVRQNPATGLFELLKGLDPSKDQSYFLHRLNQAQLSKTLFPVGDLHKTEVRRIAADIGLPNAKKKDSTGICFIGERPFREFLNRYIQHAPGPILDDRGRKLGRHVGLSFYTLGQRQGLGIGGVKEKGAQRGAGDHAPWFVARKELETNTLRVVQGHEHPWLLSHRLDAQDASWIAGHPPAAGACAAKTRYRQQDAACTVLAAQGDAFSLQFPEAQWAVTPGQSAVLYDGEVCLGGGVIAAVNG
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
B9MIA2
A6VMZ1
APT_ACTSZ
Adenine phosphoribosyltransferase
Actinobacillus
MNKQLDLIKSSIKSIPNYPKEGIIFRDITSLTEIPEAFTATVNLIAEAFRHKGITKIIGTESRGFIFGAPVAVALGLPFILVRKPGKLPREVISQSYQLEYGEDKLEIHADAIQKGDNVLVIDDLLATGGTVEACIKLVNRLGGDVKHAAFVINLPDLGGGERLRKQGVEPFTLVDFAGH
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
A6VMZ1
A6LPC4
ADDA_CLOB8
ATP-dependent helicase/nuclease AddA
Clostridium
MGNTKWTDEQLSAIETRNCNLLVAAAAGSGKTAVLVERIIRIITNEENPVDIDKLLVVTFTNAAAAEMRERIADAISKELENNPRSKNLQRQLTLLNRANITTMHSFCLDVIKNNYHRIDLDPSFRIGDQTEGILIKSEVIEELFEDKYEEEDIGFTNLVEIFSSYKNDNNLKNLVLDLYNFTMSGPWPEKWLINSAEAFNIKQLDELDRTNWVRVLAQSVKIELDGYVKMLEKAIEVTSKTDGLEPYMDNLLMELSYIKKAYESTDNGLEAMFNSLSSVQFSRLKSIKKDKVSDELSQNTVKKIRDDVKKGISELLNNAYSVNPQQMLRNIQGSYPYIKKLIELVLEFSARFSKRKRERNILDFNDLEHLCLKILSDYDDENNIIPSSIAMNFKEYFDEVLVDEYQDSNNVQETIINLVSRKNDDNPNVFMVGDVKQSIYRFRQAKPELFIEKYNTYDSSNGVNRKIQLYKNFRSRREIIDGVNYIFKEVMSEVVGELEYTDEEALNLGADFKENKFKDTIVGGPIEVNIIDKSHNETVVEDNEEQEEINNVILEGRIVAKRIKELMSKSEDEQIFKVLDKESGEYRPLKYRDIVILLRATKNWSEPLLDELSAEGIPVYADTGSGYFESIEIRTIISLLKVVDNPMQDIPVISVMRSPIMGFSAEEISDIRLVKKDNYFYENIKYISEEAYNSINESYSDVLIAKCKYFINSVDKWRNKSIYMAIDEFIWYLYMDTAYYGYVGAMPNGVLRQANLKILFQRARQFEKTSFKGLFNFINFINKLIKSSGDMGSAQVLGENEDVVRIMSIHKSKGLEFPVVFLCGLGKNFNLMDLNKSILYHDELGLGPDFIDIGKRFSIGTLAKESIKKKMKFETLSEEMRILYVACTRAKEKLIMTGTVGNLEKSAEKWLGSASLDYNRISPSEVLKGKSYLDWICMSLCQHRDGSVLSESFGTENLILKDDNSRWKVSFWNKGDLIDKTKTEVLEQGEGYELTIINNKPYDNYLYEEVDKILSYKYPFKASTTIKSNISVSDLKRRHAEEDYDTEQLYREKVKVVPKFLQEKKGLTPSEKGTAVHFVMKKIDFNRVSSTEEIKEQLHELFEKEFLLSEELKVINPTKILSFFRSDLGKKILDLNCRGEKIYREIPFYTEISSLEVDKTLDNIYKDEKIRLQGIIDCFFEYKGDIILIDYKTDYIMEGHEDEFKEKYRKQLDYYSDAIFKLTGKKVKYKYLYSFYLEKEIKII
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
A6LPC4
C3MF10
YBEY_SINFN
Endoribonuclease YbeY
Sinorhizobium
MTALDIQISVEEGDWPSEDELQGLSTRILDVTVAFLIAEEKQPFPDDPPELSLVFTDDQSIREINAEWRNQDKPTNVLSFPAFPVTPGNMPGPMLGDIIVAYETLEREAAEMEKPFEEHLTHLLVHGFLHLFGYDHIEDDEAERMEGLETRILARLGLSDPYGDQPRIDSLEQ
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
C3MF10
P0A2W0
ACP_STRPN
Acyl carrier protein
Streptococcus
MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISEIEDAFDIQIEAENDLKTVGDLVAYVEEQAK
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
P0A2W0
Q54RR5
ACDSB_DICDI
Probable short/branched chain specific acyl-CoA dehydrogenase
Dictyostelium
MIKKLILDPKNVSIIKNGIRNYSKSKSFIQPITTLSEEETLLKETVANFANEKVRPLVKVMDETSELNKGLLKDLFDMNLMGIDISDSYGGANMNFMGSIIAIEELAKVDPAISVIVDVQNTLVNNCINRYGSIQQREKYLSMLATNTVGSFCLSESGSGSDAFALATRAVRQSDGTFVLNGTKQWITNAKEAGVFIVMANVDPSQGYKGITAFIVESNNPGLRIGKKEDKLGIRASSTCEVILDNCVVKPTDILGELGRGYKIAIEGLNEGRIGIAAQMLGLAQGVFDSTIPYLMERKQFGKPIATFQGMQFTYADLAVDIEAGRLLTYNAARIKEAGLPFVFQASMAKLHCSRVAEKAASACISMLGGVGFTKEFPAEKFFRDSKVGQIYEGTSNIQLQTIAKEIVKNFNK
Probable short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA.
Q54RR5
A7FFU1
RECO_YERP3
Recombination protein O
Yersinia
MDGWQRAFVLHGRPYSETSLMLDLFTEGEGRMRVLAKGARGRRSNLKGCLQPFTPLLVRWSGRGEVKTLRSAEPVSLALPLSGSMLYSGLYVNELLSRVLEHQTSYSALFFDYLHCLQALAGSDGSPEHALRQFELAMLANLGYGVDFLHCAGSGQPVSDTMTYRYREEKGFIASLVVDHYSFTGRQLLALANREFPDADTLRAAKRFTRIALKPYLGGKPLKSRELFRQFVIKPPADPSP
Involved in DNA repair and RecF pathway recombination.
A7FFU1
B9KP41
RBFA_CERSK
Ribosome-binding factor A
Cereibacter
MAHRSHTGTGPSQRQLRVGELIRRTLADVLNRGEIHDPELNRLSITVGEVRCSPDLKVATVHVMPLGGKDVEEAIALLSKHRGELRHHITRQMTLKYAPDLRFRPDETFDRLDETRRLFSDETVMRDIRGGGEADED
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
B9KP41
A8GXR0
FPG_RICB8
DNA-(apurinic or apyrimidinic site) lyase MutM
belli group
MPELPEVETLKNSLESKLIGLVIKKVEFKRDNLRYKLSADLADQIVNTNIINVRRRAKYLIIDFNNNHSLIVHLGMSGRFTLQPNNYEVKKHDHVVFNLSNNEKLIFNDTRRFGMIYSFHTELLEKDFFANLALEPLSDSFELQYLKSKLMNKKVPIKNLLMDNRIVVGVGNIYASESLHLAKIHPDKFGKDLNDDEIKNLIAAVKNVLSKAIIAGGTTLKDFVNGDNKPGYFTQQLMVYARDGQECLSCSSSIIKTKHSGRSTFYCKSCQKA
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
A8GXR0
Q9LDD5
PYRP2_ARATH
Haloacid dehalogenase-like hydrolase domain-containing protein
Arabidopsis
MAEAIGAVSLVGHRPSIVRITVKNELKTQKSQSIVRFPVKVDYSAKGVLSHLMTQSVKKNRMSVFPIRALAMELTKEKKKDDRLPKTWNYLDSGADDKPSLWPPENKADKPSLHNPLLRQERMGCGWLGAIFEWEGVLIEDNPDLDNQSWLTLAQEEGKSPPPAFMLRRVEGMKNEQAISEVLCWSRDPVQVRRMAKRKEEIFKALHGGVYRLRDGSQEFVNVLMNNKIPMALVSTRPRETLENAVGSIGIRKFFSVIVASEDVYRGKPDPEMFIYAAQLLDFIPERCIVFGNSNQTIEAAHDGRMKCVAVASKHPIYELGAAELVVRRLDELSIIDLKKLADTDLTEFEPELEMEKEDERELPSSAVAVDDF
Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D-ribitylamino)uracil, also known as ARPP, but has no activity toward flavin mononucleotide (FMN) .
Q9LDD5
P25619
HSP30_YEAST
30 kDa heat shock protein
Saccharomyces
MNDTLSSFLNRNEALGLNPPHGLDMHITKRGSDWLWAVFAVFGFILLCYVVMFFIAENKGSRLTRYALAPAFLITFFEFFAFFTYASDLGWTGVQAEFNHVKVSKSITGEVPGIRQIFYSKYIAWFLSWPCLLFLIELAASTTGENDDISALDMVHSLLIQIVGTLFWVVSLLVGSLIKSTYKWGYYTIGAVAMLVTQGVICQRQFFNLKTRGFNALMLCTCMVIVWLYFICWGLSDGGNRIQPDGEAIFYGVLDLCVFAIYPCYLLIAVSRDGKLPRLSLTGGFSHHHATDDVEDAAPETKEAVPESPRASGETAIHEPEPEAEQAVEDTA
Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane.
P25619
Q979Y3
PDXS_THEVO
Pdx1
Thermoplasma
MALDLEKLKFGTELIKRGFSSMTKGGVIMDVTTAEQAKIAEKAGAVAVMALERVPADIRAAGGVARMADPKKIREILDAVTIPVMAKVRIGHISEAYTLEKLGVDMLDESEVLTPADPFFHLYKKKLTVPVVSGARNLPEAVRRIFEGAAMVRTKGEAGTGNIIEAVRHIRKVNEEIAIVRRMTQDEIKTAAENIASSYFQLRNEASTDLFGQSGKVLYDDVYYGMSREKIVKGISDILRQIRKLNRLPVVNFAAGGVATPADGALMMELGADGVFVGSGIFKSPDPEKMAKSIVEAVENYKDYDVVARVSEGLQGMPGIDIESIPRDSRLQERGW
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Q979Y3
O14776
TCRG1_HUMAN
Transcription factor CA150
Homo
MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
O14776
Q7MAV4
TRMD_PORGI
tRNA [GM37] methyltransferase
Porphyromonas
MRIDIITVLPEMIENTLNCSIIGRAQERGLLELKLHQLRDYSTDKWKRVDDYPFGGEPGMVMQIEPIDRIITELKTQREYDEVIFTSPDGERFDQPMANELSLLSNLIVLCGHYKGIDYRIREHLITREISIGDYVLTGGELAAAVMTDAIARLIPGVLNDAGSALSDTFQDNLLAPPVYTRPAEYKGWRVPDILLSGHEANIAKWRLEQAVERTKRLRPDLIKD
Specifically methylates guanosine-37 in various tRNAs.
Q7MAV4
P71065
EPSO_BACSU
Putative pyruvyl transferase EpsO
Bacillus
MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIMKGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIVQTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHIQLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRRTIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSSLLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM
May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles.
P71065
Q7U3I9
UREG_PARMW
Urease accessory protein UreG
Parasynechococcus marenigrum
MSSKLRLGVAGPVGSGKTALVEALCLRLRDQLQLAVVTNDIYTQEDAQFLTRAGALEPERIRGVETGGCPHTAIREDCSINRAAVADLEGQFPDLDLVMVESGGDNLAASFSPELVDLCIYVIDVAAGDKIPRKGGPGITRSDLLVINKIDLAPLVGADLSVMEADTRRMRGERPWCFTNLQNGDGLVQVVEFVLQQLPNA
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
Q7U3I9
Q8TFD3
DOTC_DOTSE
Dothistromin biosynthesis protein C
Dothistroma
MSEDHTKADNLSEKDPHSPERSDSSSHEDAHAREEEESSDDDGALDGKPASLIAIVMIALSLIGLQLAVFLSALDTTIVTVALPAISAHFNSTAAYTWVGSAYLLANAASTPIWGKLADIFGRKPMLLLANALFMIGSLVCALSINVGMLITARAIQGAAGGGLLTLVDTIIGDLFSLRTRGTYLGMIGGVWAIACALGPIVGGAFTSSVTWRWCFYINLPIDGLAFGIIFFFLKLKTPKTPILEGFAAIDWAGSFFIIGGTLMFLFGLQYGGITFPWDSATVICLLVFGVVCIVLFGLVEWKFARFPIIPLRLFQYRNNCGALLVAFFHSFVFTSAFYYLPLYFQAVKGATPILAGVYILPAVLSTGVSAAATGAFIGNTGNYLIPMYFGMSMMILGYGLLINFDAGSGWAKLIIYQLIAGIGNGPNFQAPLVALQTKIKQSDIATGTATFNFVRNIATAISVVAGQVLYQNQLKKMTSTLQQLGPAASLIAAGDAGANTQAINALPTPQRDLARSAIADALSPMWIMYTAFAAAGLFCILLVSKTELTTTHEVTEVGLEAQKKAEAERKAERQAKDLEKAQKS
Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B . One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production .
Q8TFD3
Q3JEC8
AMPA_NITOC
Leucyl aminopeptidase
Nitrosococcus
MNFHVTSGTPEKQRTAALVVGIYEDEKLSSYAQRIDKASEGYVSRLIKQGDFTGKKGQALLLFALPGVKAERVLLMGCGQKDKVTAKNLRQSWSGAVKALQACGATEAMICPLEAKPKDEELTQWARLIVETAEQALYRYEHTKSKKESLKKPLAKLTLLLDQRSQQPLAEQGIQQGQAIAKGVNLARDLGNLPGNICTPTYLADEARRLAKEYKSLKAKILEQAEMEKLGLGALLAVSRGSRQPPKLITLEYKGAPGKQKPIVLVGKGLTFDAGGISIKPGERMDEMKYDMCGGAGVLGTMQACAELELPLNVIAVVPSSENLPDGAANKPGDVLTSLSGQTIEVLNTDAEGRLILCDALTYSKRYRPDVVIDVATLTGACVIALGAHASGLLSNDQSLAEHLLAAGQTSDDRAWQLPLWDDYQQQLDSNFADMANIGGRGAGTITAACFLARFTEEFRWAHLDIAGTAWLSGKEKGATGRPVPLLTQYLIQRAQEAKTS
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Q3JEC8
A0A0C4DH26
KVD41_HUMAN
Probable non-functional immunoglobulin kappa variable 6D-41
Homo
MVSPLQFLRLLLLWVPASRGDVVMTQSPAFLSVTPGEKVTITCQASEGIGNYLYWYQQKPDQAPKLLIKYASQSISGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQQGNKHP
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .
A0A0C4DH26
B4PNV2
EI3D1_DROYA
Eukaryotic translation initiation factor 3 subunit p66
Sophophora
MSETINTAAQFPSFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGNQYSYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRNSRSGRGRNARGGLNTHGMTTLSGKNVKARDPRHGRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGVDIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTRSNYSWDIVIEKVGDKIFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQQVLKTGDQEPKYKFEESNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGDSQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNKPIIRLYDIPDNTFDSDDSDDGEGDDEGFQQVYNYAHNKI
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
B4PNV2
C1FJ20
GATB2_MICCC
Glutamyl-tRNA(Gln) amidotransferase subunit B-2, chloroplastic/mitochondrial
Micromonas
MLRRALASRSSEAAIISTRVSLPRGSIPPPPTSSSSSSSSSREGRRPRFFSTTTTSAERPVDDDEWETVVGLELHVQIGAKTKLFSGAERLYGAEANANVAPFDAALPGSLPAVNARAVELAARLGFALGADVQSRSSFDRKHYHYPDLPHGYQITQQRSPIALGGSLDVFVRDGVSGTLRVERLQLEMDTGKSSKAKSSTLVDLNRAGSTLVEIVTAPDLRGAEEASAAAETFQKVVRFLGVGDANMEEGSMRVDVNVSHRTRDGAVAGERCEVKNLNSFRSIARAVAHERTRQIALLKRGQRVRRQTRSFDPATGATAVLRDKEALLDYRFAPEPDLPPVVIEPAALRAIKAAVPELPSTAAARLTNTAGLAPKLAQTIASKPSTVAYFDACAEAADAWSTRNGTVTVDKQDVANWVTGVLVGAVKRAGVTHKGGAGGEPLRGLPESAGAARVGELLARVAASTSMDSGALEATCAAVVASMPEQLAAYRGGRTRAMGSFVGEVMKRTKGRADPRRAAEIIKTLVDQ
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
C1FJ20
P70596
MC4R_RAT
Melanocortin receptor 4
Rattus
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
P70596
P0A629
PSTC1_MYCBO
Phosphate transport system permease protein PstC 1
Mycobacterium tuberculosis complex
MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGAIRLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAVPVSVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIAHNAPDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIALGMSNWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATMTTIAATIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPVGRGI
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
P0A629
A8AFT6
TREA_CITK8
Alpha,alpha-trehalose glucohydrolase
Citrobacter
MITPALRHSGTLSFAIKLTVASTLLTFASLSAHAEEQPASPPQPPDILLGPLFNDVQSVKLFPDQKTFADAVPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKEGEKYVPPEGQSLREHIDGLWPVLTRTTESAGKWDSLLPLPEPYVVPGGRFREVYYWDSYFTMLGLAESDHWDKVADMVANFGYELDSWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKKYLPQLQKEYAYWMEGVENLQPGEQNKRVVKLDDGTVLNRYWDDRDTPRPESWMEDITTAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDDPNQLSTIRTTSIVPVDLNALLYKLEKMLARASKAAGDDANANQYEALASARQKGIETHLWNNQEGWYADYDLKSKKVRNQLTAATLFPLYVNAAAKDRASKVAAATQAHLLQPGGLSTTSVKSGQQWDAPNGWAPLQWVATEGLQNYGQDNVAMDVTWRFLTNVQHTYDREQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPKEKPCDSVPATRPAAPGASQPAPQKQVETTP
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
A8AFT6
Q54NN1
DERL2_DICDI
Probable derlin-2 homolog
Dictyostelium
MAQPFEDWYKNLPIVTKIYMTGCVVTSVSVYLGLVGPLRLYLNFPLVFGKYEFWRLFTNFFFYDEIGMNFFFHMYFLVRHSRLLEESSFRGRSADYLFMWIFGSFLLLIMDAFLFYTKIVTKVLFLAPSIAFMVIYVWSRRNPNMHISFLGLFTFSAPYLPWVILIMGYLFNHDLTTDLLGAVAGHAYYFLEDAYPLISNRRLLKTPGFLKNLMDGQEQPIVDAHQQQEVQQAQQQEVQQPVQNFLNEDDLDQQ
May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Q54NN1
A8FXC6
TGT_SHESH
tRNA-guanine transglycosylase
Shewanella
MKFELDTTQGRARRGRLVFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQNSLGSDVVMIFDECTPYPATEDEARKSMQMSLRWAQRSRDEFDKLENPNSLFGIIQGGVYEDLRDESLKGLVDIGFDGYAVGGLAVGEPKADMHRILEHTCPQIPTDKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTTEGVIKIRNARHRDDTSPLDDKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQKLMEGLRGAIETGTLDAFVEEFYTSQGREVPEVPELTD
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
A8FXC6
Q9Y2A7
NCKP1_HUMAN
p125Nap1
Homo
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Q9Y2A7
A4Y4U6
GLGC_SHEPC
ADP-glucose synthase
Shewanella
MSNVRYISNLTRETYALILAGGRGSRLHELTDWRAKPALYFGGKFRIIDFPLSNCINSGVRRVGVVTQYKSHSLIRHVMRGWGHFKKELGESVEILPASQRFSENWYQGTADAVFQNIDIIRHELPKYVMVLSGDHVYRMDYAGILAAHAESGADMTVSCLEVPIAEAAGAFGVIEVDDNMRILGFEEKPQRPKPSPDNPEMCLASMGNYVFNTEFLFEQLKKDSQNATSDRDFGKDIIPSIIEKHNVFAYPFKSPFPNEQAYWRDVGTLDSFWQANMELLSPTPALNLYDAKWPIWTFQEQLPPAKFVFDDDDRRGMALDSIVSSGCIISGATVRRSVLFNEVRVCSYSVVEDSVVLPDVVVLRHCKIKNAIIDRGCIIPEGTVIGYNHDHDRAKGFRVSEKGVTLVTRDMLGLPVGYE
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
A4Y4U6
Q52071
NIFW_ENTAG
Nitrogenase-stabilizing/protective protein NifW
Pantoea agglomerans group
MDWFTRIEGVDELESAQSFFDFFELEVDPVLLRSRHLHIMAQFNQRLTAAVPVHFVDEEESDRADWRLARRLLAESYQHTVAGPLNTQSGLAVYQRNNGSFIGWNDLLEVRP
May protect the nitrogenase Fe-Mo protein from oxidative damage.
Q52071
A1WX30
DNAJ_HALHL
Chaperone protein DnaJ
Halorhodospira
MAKRDYYEVLGVNKNASDAEIKKAYRRMAQKFHPDRNPGDEESAERFKEVKEAYEVLSDAQKRAAYDQFGHAGVDPSAGGGPRGYGGGAGPGGPDFSDIFSDVFGDIFGSGGGRGGGRSRAFRGADLRYTLELSLEDAVRGTEEQIQVPTHVECDACKGSGSRAGSKPQTCPTCKGHGDVRVQQGFFSIQQTCPRCGGEGTMVTDPCPKCRGRGRVEDRKTLNVRIPAGVDTGDRIRLSGEGEPGERGGPPGDLYVQVAVREHEFFERDGADLHCQVPVDIVTAALGGEVEVPTLDGRVNLRIPPGTQPNQVFRLRGKGVKPVRGNRQGDLLCRIHVETPVNLTKRQRELLEEFQATLQDTGGKHHPHTSSWLDKVKRFIEEWRI
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
A1WX30
D1ZMX7
LCL2_SORMK
Long chronological lifespan protein 2
Sordaria
MRTLTLLLSLLFLASPIAAQFGSFFDQMFGGGGHGGHGHQHQQQHQGHGQQQHPNVPSDPSIYQANYQRAHCDKYLCPDTLACVHYPHHCPCPWPSHEDKVELAEGQRVCVSRGGFKAGEAARKIELARQGLL
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
D1ZMX7
O14259
SFP47_SCHPO
Ubp4-interactor sfp47
Schizosaccharomyces
MNSFSSNEYSTEISTEALNNWQQLVEQRISLELEYAAKLAKLTKSIKAIKQCAPLNDLTKQVCVELMQCNKKHLEASRYFQTHVKEFMKEYVDRENKFSNETISKSSAAALMTSMENFILFTNPVYHNKLQVPSKSDMEIANSLKITQPAEKNSGTANPISAYSLEHAELDERNNQLSEALSMLRLSPFVNNYYPSYQNRKDGKSLMENRGVVLSVDTVTSPISQSPKKLTPTTSPINSTSLSFVDAKKPGSKWPSQYDFPKKTKSTEIPFKTLPSLNINNERELTKHKLPIVKPKLAVFPSNQATASTLQLAPPPVQAIPTLRNPVNLDDKKESLLKYYATHPTITPDGFPIFAYVRALYAYKATLPSEIDLNVDDTLVVLNRQKDGWWKGLVVSPTVGRIGLFPSNYIEELEY
Required for the regulation of activity and recruitment of ubp4 to endosomes.
O14259
A1U2B7
IHFA_MARN8
Integration host factor subunit alpha
Marinobacter
MAALTKADMAERLYEELGLNKREAKEMVEAFFDEIRGALSHNEQVKLSGFGNFDLRDKKQRPGRNPKTGEEIPISARRVVTFRPGQKLKQKVEAYAGTQS
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
A1U2B7
Q39KY0
ATPF_BURL3
F-type ATPase subunit b
Burkholderia cepacia complex
MNLNATLFAQMVVFLVLAWFTMKFVWPPLINALDERSKKIADGLAAAEKGKAELDAAHKRVDQELAQARNDGQQRIADAEKRAQAVAEEIKSNAQAEAARIIAQAKAEAEQQIVKAREALRGEVATLAVKGAEQILKREVDQTAHAQLLNQLKAEL
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q39KY0
D8GR66
RNFC_CLOLD
Rnf electron transport complex subunit C
Clostridium
MLKSFRGGVHPDDSKKYTANKPIEIAPIPDKVFIPVRQHIGAPTSPVVQKGDEVKKGQLIAKSDAFVSANIYASTSGKVVDIGDYPHPGFGKCQAIVIEKDGKDEWVEGIPTSRNWKELSVKEMLGIIREAGIVGMGGATFPVHVKLAPPPDKKVDVFILNGAECEPYLTADYRSMLENSDKVVAGVQIIMKILNVEKAFVGIEDNKPKAIEAMKKAFEGTKVQVVGLPTKYPQGAEKMLINVLTGREVPSGGLPADVGAVVQNVGTCIAISDAVERGIPLIQRVTTISGGAIKEPKNILVRIGTTFKDAIDFCGGFKEEPVKIISGGPMMGFAQSNLDIPIMKGSSGILGLTKNDVNDGKESSCIRCGRCLKACPMHLNPSMLSILGQKDLYQEAKEEYNLLDCVECGSCVYTCPAKRKIVQYIRYLKSENRAAGEREKAKAAKAKEKKEKEEVLK
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Couples electron transfer from reduced ferredoxin to NAD(+) with translocation of H(+) out of the cell. Essential for energy conservation during autotrophic growth. Contributes to ATP synthesis during heterotrophic growth.
D8GR66
P28773
CSF2_SHEEP
Colony-stimulating factor
Ovis
MWLQNLLLLGTVVCSFSAPTRQPSPVTRPWQHVDAIKEALSLLNDSTDTAAVMDETVEVVSEMFDSQEPTCLQTRLELYKQGLRGSLTSLTGSLTMMASHYKKHCPPTQETSCETQIITFKSFKENLKDFLFIIPFDCWEPVQK
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
P28773
Q9KLQ5
FBPC_VIBCH
Fe(3+) ions import ATP-binding protein FbpC
Vibrio
MEKQNFVVLKNICKRFGSNTVIGNLDLEIKKGSLVTLLGPSGCGKTTVLRLVAGLEKPTSGQIFIDGEDVTERSIQQRDICMVFQSYALFPHMSLYENVAYGLKMLKLPSEEVRQRVDEALKIVDLEGMGERYVDQISGGQQQRVALARALVLKPKVLLFDEPLSNLDANLRRSMRETIRELQQRFDITSLYVTHDQAEAFAVSDTVIVMKQGDIMQIGTPQELYKAPKSMFMANFMGEANMFQGHFDGQQIHINGYAIDADLEVTRDKPNGEYQIGVRPEAITLHTQGSESQACQILKSAYMGSMYEVTVKWHDQELLLQLNSAQFNHTLTQHAYVVFNPRGLFLLPYAE
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
Q9KLQ5