accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A4KWA6
CL2D3_RAT
C-type lectin domain family 2 member D3
Rattus
MSSSAHLQDAPPLLSGTLTQNEGQTSLRQSSSCGPSAASASESLSGYTESRIPHSKVRQGKGLRSIFPESRVKRYCCYGGVITVVAIAIVVPLSVTLSVKQMEQTSINNTSAASINNTSAASINNTSAACPSNWTEYGNKCFYFSEYTSNWTFSKDFCAAQGAELARFDTEEELNFLKRYKGSSGYWIGLHRESSEHPWKWTDNTQYNNLIPIRGDGQCGFLSDQLNISSSRVYVERPWICSKPKKYISQSQ
Lectin-type cell surface receptor.
A4KWA6
Q7VQX8
SYD_BLOFL
Aspartyl-tRNA synthetase
Candidatus Blochmannia
MRTAYCGQLNLSHVGLEVTLCGWVNKYRNFGKLIFVDLRDREGCIQVYFNSDAQKKTYVRAADLKQEFCIQLTGIVRSRPVSQINKNMSTGFIEIEAKFFLVLNVSNPLPLDIHQDNIEENRLKYRYLDLRRPIMFHNIQTRSRVMALTHRFMELEGLLNIDTPVLAKSTPEGARDYLVPSRLHINKYYALPQSPQMFKQLLMIAGIDRYYQITKCFRDEDLRSDRQPEFTQIDVEISFITAKKIRELMEFFICKLWKEILNVELEVFSQFSYAEVISRFGSDSPDLRNPIEMKDVSSIFQSLGNKLFICNAGCVDTIDTQVIVMNVPSGFKLTRNEIDKYSDYAKKSGIQQFLWMKIQMNDCKEITAIDGPIINLLNKNFLQLLMAQVKIENNDILFFGFNNDKNLSTTRMLSALRSKLGYDLNLVKQDSWKPLWIVDFPMFKKNTSGKLVSMHHMFTAPKDNDLICLKRNPELAVSEAYDIVINGCEVGSGSVRIHSYKLQQAMFDILGITRENQQKKFGCLMNALKYGAPPHAGIALGLDRLVMLLTKSNNIRDVIAFPKTTGAMDLMIDAPD
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Q7VQX8
Q49MG5
MAP9_HUMAN
Aster-associated protein
Homo
MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNITKDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPNGIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITENHNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWSPPSRTVFAKVF
Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
Q49MG5
Q9VWR2
CP308_DROME
CYPCCCVIIIA1
Sophophora
MLPLVLFILLAATLLFWKWQGNHWRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYTRNPGLKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPFIANGDRWRVLRADLVPLFTPSRVRQTLPHVARACQLLRDQVPLGRFEAKDLATRYTLQVVASAIFGLDAHCLGIHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRLIGHRYVPLPLQHWFRELVEARSGGDNLLQWLAESKRGLGKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPERFLNQPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKRRTRRY
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Q9VWR2
A4WNY9
ATPF1_CERS5
F-type ATPase subunit b 1
Cereibacter
MKKLSILAALAASPAMAATGPFFSLSNTNFIVTLAFLIFMGILVYAKVPGRILGMLDRRAVQIRSELEEARALREEARTILASYDRKQKEVQEQAARIVASARDEAQAAAEQAKADLKASIARRLAAAEDQIASAEAGAVRAIREQAISVAVAAASDVLARQMTPAATSASIDESIKEVEARFH
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
A4WNY9
A7H422
TRMA_CAMJD
tmRNA (uracil(341)-C(5))-methyltransferase
Campylobacter
MSLENFGNFLTLDEKHSFIKKYFKEFYTKDFKLFTSKDKHYRTRAELSFYHENDTLFYAMFDPKSKKKYIIEYLDFADEKICAFMPKLLEYLRQDDKLKEKLFGVEFLTTKQELSLTLLYHKNIEDIKSNLENLSNNLHINLIARSKGKKLIFKTENLRQTLNIQGREIFYEFNNDCFIQPNTTINEKMITWVCEILSIQKRMDLLELYCGYGNFTLALAQFFFKVLATEISKSSINFALKNCKLNNTTNIHFARLSSEELSLAIKKEREFFRLKDIRLDDFNFSHVLVDPPRAGLDKSVIDLIKKYENIIYISCNPITLKENLKELSLTHRVENFALFDQFVNTPHLECGVFLSKV
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
A7H422
Q9VIP2
PYRD1_DROME
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Sophophora
MSRKCEFLVVGGGIAGVSCAESLAIYRPNASILLLTESSIVKSVTNLVPVARYLHKFDVREQDVSEMGASFQTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGTPKLFSGKVVNPLVIGIRDTDSVQLLQRKLATAKDVLILGNGGIASELAYELKDVNVHWVVKDSHISATFVDPGAAEFFHIAMNECNAKDSSPVVAIKRMRYSEVLPKEQTNNHGAALGPDWHRSVDLSGAREGEENRLPKIYYKSRISSVQDLADDAGAIVKLEHEDGSFQQLTCDFIVSATGVWPNTDYTCDSPLQFSDDGGISVDEMMRTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQARQMGSMAGRSMAAASEGESVYQDFCFELFGHVTKLFGYPVVLLGRFNGQDLGRDYEILVRCTRNKEYIKFVLQNGRLRGAMLIGNTDLAETCENLILNGIDLEPYGDDILNPDIDIEDYFD
Probable oxidoreductase.
Q9VIP2
Q95MN4
CY24A_RABIT
p22-phox
Oryctolagus
MGQIEWAMWANEQALASGLILVAGGIVATAGRFTQWYFGTYAIAAGVLVCLLEYPRGSRAKGSTLERCGQRYLTAVLKLLGPLSRNYYFRAALHLALSVPAGFLLATILGTVCLVIASIIYLLAAVRGEQWTPIEPRPKERPQVGGTIKQPPSNPPPRPPVEARKKPGEEDATPAGGPPGGPRVNPIPVTDEVV
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Q95MN4
Q91W89
MA2C1_MOUSE
Neutral/cytosolic alpha-mannosidase
Mus
MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCSVTLSSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGQEVHLCWESDGESLVWRDGEPVQGLTKEGEKTSYVLSERLRASDPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSQAKLAVFHRDVHSLLVDLELLLGVAKGLGEDSQRSFQALHTANQMVNICDPAQPETYPAAKALASKFFGQHGGESQHTIHAMGHCHIDTAWLWPFKETVRKCARSWSTAVTLMEQNTDFIFACSQAQQLEWVKSQYPGLHARLQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFLTQKLSWNLVNSFPHHTFFWEGLDGSRVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGRTNHSGFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPRVQLSSPGQLFTALERDSGQLCTWVGELFLELHNGTYTTHAQLKKGNRECEQILHDVEVLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNPLLSAAAAALCAGEPGPKGLLIINTLPWKRTEVLALPKPCGAHSLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQETDGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDVMDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARIRSPQATYEIQFGHLQRPTHNNTSWDWARYEVWAHRWIDLSECDFGLALLNNCKYGASVRGNVLSLSLLRAPKAPDATADMGRHEFTYALMPHKGSFQEAGVIHAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAERCHQHRTLVLRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSLLLVLQSPPN
Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.
Q91W89
Q9UVP6
VPS1_PLEER
Versatile solid phase peroxidase 1
Pleurotus
MAFAKLSAFVLALGATVALGESPTHRCLNKRVTCATGQTTANEACCALFPILDDIQTNLFDGAQCGEEVHESLRLTFHDAIAFSPALTNAGQFGGGGADGSMIIFSDTEPNFHANLGIDEIVEAQKPFIARHNISAADFIQFAGAIGVSNCAGAPRLNFFLGRPDATQIPPDGLVPEPFDDVTKILSRMGDAGFSTVEVVWLLASHTIAAADHVDPSIPGTPFDSTPSTFDSQFFLETMLQGTAFPGTPGNQGEVESPLAGEMRLQSDFLLARDSRSACEWQSMVNNMPKIQNRFTQVMKKLSLLGHNQADLIDCSDVIPVPKTLTKAATFPAGKSQADVEIVCNAAATPFPALASDPGPVTAVPPVPPS
A versatile ligninolytic peroxidase that combines the substrate specificity characteristics of the two other ligninolytic peroxidases, manganese peroxidase and lignin peroxidase.
Q9UVP6
Q2T880
ATPB2_BURTA
F-ATPase subunit beta 2
pseudomallei group
MGATVADLQATNGTAQAQAKHGVSDGRVVAVRGAVVDVAFDGGVLPALNDALVIPIDGAAPILAEVHAHLSDAAVRALALGPTGGLRRGAAVRATGGPIRVPVGDAVLGRLLSVTGEPGDDGAALAADVARRPIHRGAPPLAEQKSATALFATGIKVIDLLAPLAQGGKAAMFGGAGVGKTVLVMELIHAMVERYRGISVFAGIGERSREGHEMLLDMRGSGVLGRTVLVYGQMNEPPGARWRVPLTALAIAEYFRDERAQNVLLLMDNVFRFVQAGAEVSGLLGRLPSRVGYQPTLASEVAALQERIASVEGAAVTAIEAVYVPADDFTDPAVTAIAAHVDSMVVLSRAMAAEGMYPAIDPVASSSILLDPLVVGEAHVEVAIEVRRVIEHYRELQDVIALLGIDELGADDRRIVGRARRLQRFLTQPFAVTEAFTGQAGASVEIADTIAGCRAILRGDCDDWRESSLYMVGTLDDARRKEEAAREADARRDAAAGAASGSAGPQGAQHGR
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q2T880
Q8Y3C3
GATA_RALSO
Glutamyl-tRNA(Gln) amidotransferase subunit A
Ralstonia
MTASTLKTLSAQLAAKEVSAVELARHYLARIEARADLNAFIHVDPEATLAQAQAADARLAAGDAGPLAGIPIAHKDVFVTRGWRATAGSKMLDSYVSPFDATVVERLAAAGMVTLGKTNMDEFAMGSSNENSHFGPVKNPWDVARVPGGSSGGSAAAVAADLAPAATGTDTGGSIRQPASFSGITGIKPTYGRVSRYGMIAFASSLDQGGPMARTAEDCALLLSAMAGFDARDSTSLEPGRGGDAEDFGRLLGRPLEGADAARPLAGLRIGLPQEYFGAGLADDVRTAVRAALAELETLGATLVDISLPKTELSIPTYYVIAPAEASSNLSRFDGVRYGHRAAAYRDLADMYRKTRAEGFGWEVKRRILVGTYVLSHGYYDAYYLQAQKIRRIIAQDFQNAFGQCDVIMGPVAPTVAWKLGEKTDDPLQMYLADIFTLSTSLAGLPGMSVPAGFGANGLPVGLQIIGNYFEEARMLQIAHAFQQATDWHTRRPAA
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Q8Y3C3
P96121
GPMA_TREPA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Treponema
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHKSWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVARVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAARAQAVADQGKSN
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
P96121
Q6D8D0
LPXB_PECAS
Lipid-A-disaccharide synthase
Pectobacterium
MSSRPLTIGLVAGETSGDILGAGLIRALKEKVPGARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLPRLLKIRRDLTQRFSELQPDVFVGIDAPDFNITLEGNLKQHGINTIHYVSPSVWAWRQKRVFKIGKATNLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLHPDKMTARATLGIAPDAHCLALLPGSRGAEVEMLSADFLNTAVLLRQHFPDLEIVVPLVNSKRREQFERIKSSVAPDLRVHLLDGQAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAQRLVKTPWVSLPNLLAGRELVTELLQTDCTPDKLAAALLPLFADTDKMAELRTTFVDLHQQIRCNADEQAAQAVLELVTPR
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q6D8D0
Q9ZL46
MOAC_HELPJ
Molybdenum cofactor biosynthesis protein C
Helicobacter
MPLTHLNEENQPKMVDIGDKETTERIALASGRISMNKEAYDAIINHGVKKGPVLQTAIIAGIMAAKKTSELIPMCHPIMLNGVDIDILEEKETCSFKLYARVKTQAKTGVEMEALMSVSIGLLTIYDMVKVIDKSMTISGVMLEHKSGGKSGDYNAKK
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Q9ZL46
Q9B5R1
CYB_CEPNI
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Cephalophus
MTNIRKTHPLLKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTYMETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPTGISSDADKIPFHPYYTIKDILGALLLILVLMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLILMPLLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPMASTIENNLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9B5R1
Q814W0
ATPA_BACCR
F-ATPase subunit alpha
Bacillus cereus group
MKHMSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q814W0
C0MAH5
TGT_STRE4
tRNA-guanine transglycosylase
Streptococcus
MTNYPITYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEIGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQAILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAADLVSMDFPGYSIGGLAVGESHAEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFAEDFTPLDHHCDCYTCQHYTRAYLRHLLKADETFGMRLTSYHNLYFLVNLMKQVRQAILDDNLLEFRQDFLERYGYNSSSRNF
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
C0MAH5
P07856
SERI1_BOMMO
Silk gum protein
Bombyx
MRFVLCCTLIALAALSVKAFGHHPGNRDTVEVKNRKYNAASSESSYLNKDNDSISAGAHRAKSVEQSQDKSKYTSGPEGVSYSGRSQNYKDSKQAYADYHSDPNGGSASAGQSRDSSLRERNVHYVSDGEAVAASSDARDENRSAQQNAQANWNADGSYGVSADRSGSASSRRRQANYYSDKDITAASKDDSRADSSRRSNAYYNRDSDGSESAGLSDRSASSSKNDNVFVYRTKDSIGGQAKSSRSSHSQESDAYYNSSPDGSYNAGTRDSSISNKKKASSTIYADKDQIRAANDRSSSKQLKQSSAQISSGPEGTSVSSKDRQYSNDKRSKSDAYVGRDGTVAYSNKDSEKTSRQSNTNYADQNSVRSDSAASDQTSKSYDRGYSDKNIVAHSSGSRGSQNQKSSSYRADKDGFSSSTNTEKSKFSSSNSVVETSDGASASRESSAEDTKSSNSNVQSDEKSASQSSSSRSSQESASYSSSSSSSTLSEDSSEVDIDLGNLGWWWNSDNKVQRAAGGATKSGASSSTQATTVSGADDSADSYTWWWNPRRSSSSSSSASSSSSGSNVGGSSQSSGSSTSGSNARGHLGTVSSTGSTSNTDSSSKSAGSRTSGGSSTYGYSSSHRGGSVSSTGSSSNTDSSTKNAGSSTSGGSSTYGYSSSHRGGSVSSTGSSSNTDSSTKSAGSSTSGGSSTYGYSSRHRGGRVSSTGSSSTTDASSNSVGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDSNSNSAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDSNSNSAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDASTDLTGSSTSGGSSTYGYSSDSRDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSDCGDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSDSRDGSVSSTGSSSNTDASTDLAGSSTSGGSSTYGYSSNSRDGSVSSTGSSSNTDASTDLTGSSTSGGSSTYGYSSSNRDGSVLATGSSSNTDASTTEESTTSAGSSTEGYSSSSHDGSVTSTDGSSTSGGASSSSASTAKSDAASSEDGFWWWNRRKSGSGHKSATVQSSTTDKTSTDSASSTDSTSSTSGASTTTSGSSSTSGGSSTSDASSTSSSVSRSHHSGVNRLLHKPGQGKICLCFENIFDIPYHLRKNIGV
Provides the silk fibroin thread with a sticky coating. Acts as a cement by sticking silk threads together.
P07856
A7Z6S2
ISPG_BACVZ
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Bacillus amyloliquefaciens group
MSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEATVAEINRLAEAGCQIVRVACPDERAANAIADIKKQISIPLVVDIHFDYKLALKAIEGGADKIRINPGNIGRREKVEAVVKAAKEKGIPIRIGVNAGSLEKRILEKYGYPTADGMVESALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKASKAFDYPLHLGITESGTLFAGTVKSAAGLGAILSKGIGNTLRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRIEIDLISIANEVEEYISKVKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGQIVRKVPEETMVEELKKEIDKLAEEHYAKLEAEKAKAEQETQKA
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
A7Z6S2
Q1IF59
DNAK_PSEE4
Heat shock protein 70
Pseudomonas
MGKIIGIDLGTTNSCVSVLENGTAKVIENAEGARTTPSIIAYANDGEILVGQSAKRQAVTNPHNTLFAVKRLIGRRFDEEVVQKDIKLVPYKIVKASNGDAWVQASGKDMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGMDKAKGDHTVIVYDLGGGTFDVSVIEIAEVDGEHQFEVLATNGDTFLGGEDFDMRLIDYLVDEFKKESGMDLKNDPLALQRLKEAAEKAKIELSSAQSTDVNLPYITADATGPKHLNVKISRAKLEALVEDLVTRTIEPCRIALKDAGIDASKIDDVILVGGQTRMPMVQKAVADFFGKEARKDVNPDEAVAMGAAIQGAVLAGDVKDVLLLDVSPLTLGIETMGGVMTALIEKNTTIPTKKSQVFSTADDNQGAVTIHVLQGERKQASQNKSLGKFDLADIPPAPRGVPQIEVTFDIDANGILHVGAKDKATGKAQSIVIKANSGLSDEEVERMVRDAEANAEEDRKFEELAAARNQGDALVHSTRKMVADAGDKVTAEEKTAIEAAVVALEAAVKGDDKAAIDAKVEELSKVSAPVAQKMYAEQQAEQPQGGAQQAEPEAKHDDVVDAEFEEVKDNNKQ
Acts as a chaperone.
Q1IF59
B8D9I9
METK_BUCA5
Methionine adenosyltransferase
Buchnera
MTEYLFTSESVSEGHPDKIADQISDALLDEILKQDLKARVACETYVKTGMVLIGGEITTTAWVDVEEITRKTINDIGYVNSDAGFDANSCAVLSAIGKQSPDINQGINRFDPLKQGAGDQGIIFGYATNETEFFMPAPITYAHLLMQKQSELRKKNILPWLRPDAKSQVTFKYNNGNIIAIDTVVLSTQHQENITQKYLKEAVMDEIIKPVLPDKWLTKNTKFFINPTGRFVIGGPMGDCGVTGRKIIVDTYGGMSRHGGGAFSGKDPSKVDRSAAYAARYVAKNIVASGLAARCEIQLSYAIGIAEPISIMIDTFNTGKISNSALISLVRSIFDLRPYGLIKMLNLLQPIYLKTAVYGHFGRKEFPWENLDKVNELS
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
B8D9I9
C3NDK6
FAU1_SULIY
RNA-binding protein FAU-1
Sulfolobus
MKGRVRIRGIYATALTSIFSSLSYEIVQQSVEIAERFMREVNNLPADITIKDFEYDRGKIIVMGNGTIEEDLHDVFKYSFHWKSPIKLYSVIEADESCTYGNFKVEPCLEEGIVIKPPYDGKIVLSETKAVSKYAMVWRGKGVTTFSEHINNEEERLRLLTLSSPLNRKGYNVKWRSNAKYATLNELKEDLERLVLRYENREFRDQGEDFYLITLSLPDKLHLDEVRKSIVNTVKYHHLLKLSYNREVDSLEKDKEGSPVKLLEALISDFMKIEHIKADGKAIYLRGGKVIEKEVNNDGYRITLRREINGNGVLDGIGKRIENGDYDIVEYNSDKWYQIHRYYSGIDNSLKGIYINISTPPELLKGKIRYLDLEIDIAIRDSEIIVLDEDELNKKSIYMYSSLVNKAKEVANYLIDCIQQNKLI
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.
C3NDK6
D4GU71
AGL14_HALVD
Probable low-salt glycan biosynthesis reductase Agl14
Haloferax
MYAFVTGANGLLGSVVVRTLREQGHAVVGSYHSEEPTFDCPLHQVDITDTERVVELLDEYDVDLVINCAAYTDVDGCESNPEVATAVNGTAPGDLAAVCDDREIPFIHYSTDYVFDGETDGFYEEGDEPAPIQEYGRSKLTGEHAVRDVNPDALILRLSFVYGARGDTSDLVGFPQWVASTLAAGDTVPLFTDQTMTPSRAGNVATTTLELLDAGVSGTFHVASQSAVTPSDFGEKICEVIGGDATLIESSVMADLDRPAARPRRSCLDVSNVEGELGCSQPTLEDDLAALEAAFSDYSS
Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier.
D4GU71
P58409
HCXB_ECO57
Phenylpyruvate reductase
Escherichia
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDDFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTRRERQEQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS
Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions.
P58409
P13716
HEM2_HUMAN
Porphobilinogen synthase
Homo
MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
P13716
A5ESQ6
FMT_BRASB
Methionyl-tRNA formyltransferase
unclassified Bradyrhizobium
MPLRLIFMGTPDFAVPTLLELAGHGHEIAAVYTRAPKPGGRRGLALVPTPIETEARRLGIPVVTPKTLKTEEALTAFRAHQADAAVVVAYGMILPQAILDAPKLGCYNLHASLLPRWRGAAPINRAIMAGDAETGVMVMKMDVGLDTGDVAMAERLPITDAMTASDLHDQLARIGADLMVRAMAALERGGLTLTKQADAGVTYAAKIEKAEARIDWSKPANAVLRHIHGLSPFPGAWSEVTLDGEAVRLKILRCALADGRGEPGAVINEQLTIACADGAVRVTELQRAGKGPMKAADFLRGTRVAPGLRFG
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
A5ESQ6
Q9QYZ8
DKK2_MOUSE
Dickkopf-related protein 2
Mus
MAALMRVKDSSRCLLLLAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQSANRSAGMNQGLAFGGSKKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACMLCRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHSKMPHIKGHEGDPCLRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Q9QYZ8
Q49YP8
FUMC_STAS1
Iron-independent fumarase
Staphylococcus
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRGAALANHALGKLSDAKKDAIVYACDRVLNKELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANTYLKEQGIDESIHPNDDVNKSQSSNDTFPTAMHVALYNEVETKLEPALKTLRDTFKQKEEQYHDIIKIGRTHLQDATPIRLGQEISGWRYMLDKCETLLSESKAHILNLAIGGTAVGTGINAHPEFGDKVAKFIAENTGYPFVSSENKFHALTAHDEVVQLHGTLKALATDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTAVGIASSQGNFELNVYKPVILLNTLQSIYLLADGMDTFNNNCAVGIEPIPENIDNYLNQSLMLVTALNPHIGYEKAASIAKKAHREGLTLKESAIDSGYVTEEQFEQWIKPEDMVEPK
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
Q49YP8
A1VPR5
ATPB2_POLNA
F-ATPase subunit beta 2
Polaromonas
MTDGGLQADAPHLGVVVSVRGSVVDVRFDTHLPPIHTVLHADEGRIIVEVLAQRDAHHVRAIALTPTQGLARGMPVVDTGGPLKAPVGKGILSRMFDVFGNTIDRLPAPPDIQWRSVHRAPPALARRSTRSEVFVTGIKVIDVLLPLERGGKAGLFGGAGVGKTVLLTEMIHNMVGHQEGISIFCGIGERCREGEELYRDMKDAGVLPSMVMVFGQMNEPPGSRFRVGHAALTMAEYFRDDEHRDVLLLIDNIFRFIQAGSEVSGLMGQMPSRLGYQPTMGTELSGLEERIANTDSGAITSIQAVYVPADDFTDPAAVHTFSHLSASIVLSRKRASEGLFPAIDPLQSSSKMATPGIVGERHYALAQEIRRTLAQYAQLKDIIAMLGLEQLSPQDRNVVGRARRLERFLTQPFFTTEQFTNLPGKLVSLEDALDGCERILRDEFKDCPESALYMIGKIDEARARKTEAIDVHES
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
A1VPR5
P43100
NIA_BEABA
Nitrate reductase [NADPH]
Beauveria
MAVKSQLGVTYTTKTFPPSPPRTVGNSHAGSDDERDEVDATPTTPPVEKLGQLLKPYSLPPTNTPTHVLPEDLKTPDHRVNRDPRLIRLTGVHPFNVEPPLTDLYDEGFLNSENLHYVRNHGPVPHCPDDESLNWTFTVDGLVEKPFTIAVRDLIQKYDQFTYPVTLVCAGNRRKEQNVVRKSKGFSWGAAGLSTALWTGVPIGALLRMAKPKRAAKYVCFEGADKLPNGYYGTSVKLNWCMDENRGIMVAHKMNGQSLHPDHGKPVRIIIPGQIGGRSVKWLKKITITSEPSDNWYHIYDNRVLPTTISPDASANLPDVWKDEKYAIYDLNANSAICYPRHDERLVLATAPDTYKVRGYAYGGGGKRITRLEVTLNKGKSWLLAGIHYPEDDYRRAPDGDLLYGGSTDMWWRETCFCWCFWEIDIPVADLSAADDIMIRAMDEGMMVQPRDMYWSVLGMMNNPWFRVVIHKEDGALRFEHPTQPALMPGGWMERVKRRGGNLTNGFWGEKTAAEEEQVLAEPEKEICMTNPKVVRIISLEELKAHEGEMEPWFVVNGHVYNGTPYLDNHPGGATSIINAAAQDATEEFMTIHSENAKAMMPQYHIGTLNDAARKALEGSAEESPASDPTRAVFLQPKYWSKAILETKTDVSSDSKIFSFRLDHAAQSIGLPTGQHLLVRLRDPATREAVIRAYTPLSETHAKGQLDILIKIYRDVPGQPGGKMTQALDSIPLGHFVDIKGPVGKFEYLGKGHCTVSGTSRHVRRFVMICAGSGVTPIFQVLRAVTSDAQDGTECLVLDGNRCEKDILCREELDAMVARAPARTTLLHKLSRPDASWCGLRGRMDKEYLEEHIGGFRKSDGREMVLVCGPAALEETVRSVLVEMAWKPEDMLFF
Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
P43100
B8J4R6
RL31_DESDA
50S ribosomal protein L31
Desulfovibrio
MKKDIHPKVFNATITCACGNEEKVLSTKGEQVNVEVCSACHPFFTGKQRFLDTAGRIDRFRKKYAKFEQK
Binds the 23S rRNA.
B8J4R6
P0CO53
KYNU_CRYNB
L-kynurenine hydrolase
Cryptococcus neoformans species complex
MSNDLPTKKDLVKWDQEDALNWTRGEYEIPNSKACGGEADGKAIYFCGNSLGLLNKKARQHIMEELDVWSTSSVTGHFNHPYQRPWKHVDEPLTPHLAKLVGAREEEVAHTSTLTSNMHNLFTSFYQPTEKRWKIVIEKGSFPSDWYAVHSHPRLHDKVLRPEQIDNAIIALVPREGEDTLRTEDILKVLDDNKDSIAIVWLPLVQYYTGQLFDISSISPKVHEIGALLGLDMAHGIGNVECKLNEWNVDFAVWCTYKYLNAGPAAIGGFYIRSGLEDGGRRLAGWWGNDARTRFHMSPNFQPTPGAKGYQHSCTPVFSSIPLLATLQLIEAVGFSNMVEKARRLTGTLEALLKASRYYVHPADPKGKIGFKIITPAAPYRGTQLSLVILPEEEHVMPKVFDRMLRKGLVGDERKPSVIRLSPVVLYNTFEEVGRAVEIVEEALEEEEEERKR
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
P0CO53
P06131
FDHA_METFO
Formate dehydrogenase subunit alpha
Methanobacterium
MDIKYVPTICPYCGVGCGMNLVVKDEKVVGVEPWKRHPVNEGKLCPKGNFCYEIIHREDRLTTPLIKENGEFREATWDEAYDLIASKLGAYDPNEIGFFCCARSPNENIYVNQKFARIVVGTHNIDHCARLCHGPTVAGLAASFGSGAMTNSYASFEDADLIFSIGANSLEAHPLVGRKLMRAKMNGAYFIVADPRYTPTAKQADQYIPFKTGTDVALMNAMMNVIISEGLEDKEFIEKRTKNYEELKEVVSKYTPEMAEEITQVPADVIRDIAIKYAKADKAAIVYSLGITEHSHGVDNVMQTANLAMLTGNIGRLGTGVNPLRGQNNVQGACDMGALPTDYPGYRKVADQEVMEDVTCTWGCSDLGCEPGLKIPEMIDAAAKGDLKVLYITGEDPVISDPDTHHVEEALNNLDFFVVQDIFMTDTAEFADVVLPAACWAEQEGTFTNGERRVQLIRKAVDAPGESKYDWEIFCDLAKKMGADPEMFTYESAQDIFEEVRTVTPQYAGMNRERLDRPEALHWPCPSEDHPGTAMMHIEKFAHPDGLGIFMPLEEQGPMETPDDEYPLILTTTRLLFHYHAAMTRRAATLDREVPTGYVEINTEDAAELGIANKEKVKVKSRRGEIEIAARVTDDIVKGIVNIPMHFRECSANILTNAAAIDPKSGMPEYKACAVAISKMEGSK
Catalyzes the oxidation of formate.
P06131
Q9LS90
LFR_ARATH
Protein LEAF AND FLOWER RELATED
Arabidopsis
MQKRELGKSGGNSGGSSGPPAKRGRPFGSTSANSAAAAAAAAAADAMSPSALLGPSLLVHNSFVEQNNRRIVLALQSGLKSEVTWALNTLTLLSFKEKEDIRRDVMPLAKIAGLLDALLLIIDDWRDIALPKDLTRGTRVRTLGTNASVTGFGNEYDALASIQPPGSGIGSSAAEALGKKSTGKHQSSQWWMEEDGLFNLDDEGRSEKQMCAIAASNVIRNFSFMPDNEVVMAQHRHCLETVFQCIHDHMTEDEELVTNSLETIVNLAHLMDLRIFSSLKQSYININEKKAVQAVVGILNSSVKAWNCAAAELLGRLIINPDNEPFISPLIPQIHKRLIDLLSIQAVDAQAAAVGALYNLVEVNMDCRLKLASERWAVDRLLKVIKTPHPVPEVCRKAAMILENLVSEPQNRGLLLAYENAFAELLFQEGKYSDSFARILYELTARSNSRVASARGIWGM
Involved in leaf and flower development . Plays roles in leaf development partly by associating with AS2 and repressing KNAT1/BP transcription . Required for the formation of anther cell layers and normal expression of genes that regulates anther development .
Q9LS90
A4WNA4
RPO3_PYRAR
DNA-directed RNA polymerase subunit D
Pyrobaculum
MPRVSIVEKSQLFLKAIVEGVPPSLVNSLRRVIISELPVMAIDTVVVVNNTSVMYDEFLAQRLGLIPLTTPLHSLPTYEECATGVADPTECGTRLVLQVTADGDVTVYSGDLTSERPDVVPVYKDIPIVKLVKGQSIVIEAYAKLGIAKDHAKWQAATASYYYYPKVIIKDEKCREICKEICPDLEDPVKCTFNKAWTCKDLCKGGLDVEWEKNKYVFWVESFGNYGVDVALKEAFRILKRKFEAFTEELVKKASSGER
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A4WNA4
A9BPR7
RS10_DELAS
30S ribosomal protein S10
Delftia
MSKQKIRIRLKAFDYKLIDQSAAEIVDTAKRTGAIVKGPVPLPTRMKRFDILRSPHVNKTSRDQFEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
Involved in the binding of tRNA to the ribosomes.
A9BPR7
P40319
ELO3_YEAST
v-SNARE bypass mutant gene 1 protein
Saccharomyces
MNTTTSTVIAAVADQFQSLNSSSSCFLKVHVPSIENPFGIELWPIFSKVFEYFSGYPAEQFEFIHNKTFLANGYHAVSIIIVYYIIIFGGQAILRALNASPLKFKLLFEIHNLFLTSISLVLWLLMLEQLVPMVYHNGLFWSICSKEAFAPKLVTLYYLNYLTKFVELIDTVFLVLRRKKLLFLHTYHHGATALLCYTQLIGRTSVEWVVILLNLGVHVIMYWYYFLSSCGIRVWWKQWVTRFQIIQFLIDLVFVYFATYTFYAHKYLDGILPNKGTCYGTQAAAAYGYLILTSYLLLFISFYIQSYKKGGKKTVKKESEVSGSVASGSSTGVKTSNTKVSSRKA
Component of a microsomal membrane bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase III, which synthesizes 20-26-carbon fatty acids from 18-carbon-fatty acyl-CoA primers such as stearoyl-CoA by incorporation of malonyl-CoA . The enzymes active site faces the cytosol, whereas VLCFA length is determined by a lysine near the luminal end of transmembrane helix 6 . Plays an important role in lipotoxic cell death induced by oleic acid through maintaining a balanced fatty acid composition in thr plasma membrane . Affects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3 .
P40319
A6ZSZ4
IPI1_YEAS7
Involved in processing IST2 protein 1
Saccharomyces
MTKSRKQKQKKQDFLRKKLKVGKPKEKARNATDTSFVSKTISIRNQHLDQNPHDLTKRLTLLKHHNINVRKETLTTFQKSIPSIIKSRLMTPLLTQSIPLICDESQQVRQGLIDLVDEIGSHDAEILKLHCNIFVLYINMAMTHIVTQIQADSTKFLSHLLKYCGDEVVRKSWVKLLNGVFGVLGWGQVGKNDSASIVQTKKRNAKYVTIHLNALYTLVEYGCQDERARSDGDTAETTEDSGTLRNPYLIPDYPQPFEHLKLFTRELKVQDATSSGVNATLLSLATQDIDTRKAVFIEQFLPIVRKKIEVIIKEGGECGKSANKLKTLLAKIFD
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
A6ZSZ4
Q3IUB3
NAC_NATPD
Nascent polypeptide-associated complex protein
Natronomonas
MFGGGGGLNPRKMKQMMNQMGIDLEEIDAEEVVIRTADEELVFDDAEVQLMDAQGQQTYQVVGEPESRERGDSGSEDDSETESGGEFSEDDVEIVAQRAGVSESTARETLEETGDLAAAVQKLE
Contacts the emerging nascent chain on the ribosome.
Q3IUB3
A4G1U8
RUVA_HERAR
Holliday junction ATP-dependent DNA helicase RuvA
Herminiimonas
MIGRLSGVLLEKNPPQLLVDCNGVGYEVNVPMSTFYNLPGLGEKVALLTHLTVREDAHILFGFGTAEERNVFKQLVKITGIGARTALSILSGMSVADLSNAITLQEAGRLTKIPGIGKKTAERLLLELKGKLGADLGAAGGVIHSDATSDILNALLALGYSDKEALLAMKQVPAGTGVSDGIKLALKALSKA
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
A4G1U8
Q1IZH7
SECA_DEIGD
Protein translocase subunit SecA
Deinococcus
MFRVLNKVFDTNQRDVQRIVKTVVQPVNALEEETMKIENLAEAFMRLRQRVQEGGESLDDVLVPAFALIREAGRRAIGKRHYDVQLIGGTALHQGRIAEMRTGEGKTLVATLALALNALEGKGAHLVTVNDYLARVGAEEMGLLYRTLGLSVGLITRDMQPHQRQAAYACDITYVTNSELGFDYLRDNMAQSREQLVLRADNPLHYAIVDEVDSILIDEARTPLIISGAAEKATDLYYVYAKLVKRLQRGEPAEPGKRTEPTGDYTIDEKGKQVHLTEQGIAKIERLLSLGDLYSPENMDKAHMITQAIRARELYHREKDYIVNAEGEVVIIDEFTGRSMPGRRYGEGLHQAIEAKEGVKIENENQTLATITYQNFFRLYDKFAGMTGTAKTEEKEFLDIYGSDVLVIPTNKPVIRQDADDLVYRTRMGKYQAVVEEVKQMHATGRPILIGTASIDTSEQLSALLKQAGIRHSVLNAKYEAQEASIIAQAGRSGTVTIATNMAGRGTDIMLGGNAEFILGEAIEQNFGISRFTPEAEAFIKAIGREDPEAVTLGLRIPGMTEQFIRQAQQLQKDIIADRERVRELGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYVSFEDDLMRLFASDRVVAMMDRLGMDDTQPIEAKMVTGAIERAQARVEDRNFGIRKQLLEFDNVMSKQRDIIYAQRREVLLGTDEDVEESTEGMIADFTEMQLAFYAPIDQPAESWDLETLRTNMLEAVPQLEHYDFEALRHMAPEAAHAHLLEAVADAFDARKAELGPTMLNSLARYVLLQVVDQHWKEHLHGMDVLRQGIGLRGYGQRDPFTEYKFEATNMFNDMIDNLKADVTKFIFRMQFGQAS
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Q1IZH7
Q65D22
DEOC2_BACLD
Phosphodeoxyriboaldolase 2
Bacillus
MTIANLIDHTALKPHTQKSEIKKLIEEAKAYQFASVCVNPTWVEFAAEELKGTEIDVCTVIGFPLGANTTETKAFETKDAIAKGATEVDMVINIAALKDGNDDFVEADIRAVVEAAKGKALVKVIIETCLLTDEEKERACRLAVAAGADFVKTSTGFSTGGATAEDIALMRKTVGPDIGVKASGGIRTKEDVETMISNGATRIGASAGVSIVSGAEGKNEDNY
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Q65D22
Q5X3L5
NTPP_LEGPA
Nucleotide pyrophosphatase
Legionella
MSKFLQQKPIILASSSTIRHKLMKSLGLDFLVVPSNCNEEEIKTRHNSDELVELGITLAKIKALDVSQHYPEHYIIAADQLCVADKRVFNKPLNHQTAVSHLRELSGKEHQQIACLCIVKESKILWQYHETATLTLHHLSEKTIEAYLQAEKPYQSCGAYQYEGLGKWLFKEVQGSEDTILGLPLMPLVNALVNLKVVGI
Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Q5X3L5
Q9KQ15
FLGJ_VIBCH
Muramidase FlgJ
Vibrio
MINNSNDIGFIQDIAGLDKLRQKAVNGDENAGQSALTAAARQFESIFTSMMLKSMRDANSDFKSDLMSSQNEDLYRQMLDEQMASEFSSSGSLGLADMIVAQLSTGQTASEQKGEDGFQEAMRRVEHARKTASERSNEDLVAAVYPLRKTQAVQSTQFDSRHSFVTKLKPYADKAARMLGVDSSLLIAQAALETGWGQKMVKNARGNSNNLFNIKADRSWQGDKVATQTLEYHNNVPVVEKAAFRSYASFDESFNDYVRFLENNPRYTNALDHGGNSERFIHGIHRAGYATDPQYADKVLRVKAQIDQMNLYKSPAGIFRRHSFSSSIFSAYQS
Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
Q9KQ15
O84875
CDUB2_CHLTR
Deubiquitinase and deneddylase Dub2
Chlamydia
MEPIHNPPPQTCSYSRPSTTYTSFKDASCGTKVTRIIIALFLIVISCGLILCAYTFRDLLDADYSAQEGPQQATKLLQQLDKVLTGPPLPIWDNEHLFQFSCLMQNKHRRVLPIDICNPLTKFNFLEYICNCLMTKQSVNVNETDMCELFCPPTCTPENYRRLLCTSSVFPFVMWHDPSADTQEAMLTKMDQTMSSGRVGNSHWVLVIVDIEHRCVTFFDSFYDYIASPQQMREQLEGLAASLGAIYPKEGGADSDQEELLSPFQVRIGSTVKVQSPGEFTCGAWCCQFLAWYLENPDFDLEEKVPTNPSERRALLADFISTTEQAMSRYSSLSWPTTD
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities.
O84875
Q6JWR2
S38A7_RAT
Solute carrier family 38 member 7
Rattus
MAQVSINSDYSEWGSSTDAGERARLLQSPCVDVVPKREGEASPGDPDSGTTSTLGAVFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEVVWAVCGKLTGVLCEIAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPDGASGSPWYTDRKFTISLTAFLFILPLSIPKEIGFQKYASSLSVVGTWYVTAIVIIKYIWPDKEMRPGDILTRPASWMAVFNAMPTICFGFQCHVSSVPVFNSMRQPQVKTWGGVVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLRSYPSEDVAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYKGTPVEEDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFIFPGLCLIQAKLSEMEEVKPASWWALVSYGVLLVTLGAFIFGQTTANAVFVDLLA
Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.
Q6JWR2
Q83S80
FLAV_SHIFL
Flavodoxin 1
Shigella
MAIHGIFFGSDTGNTENIAKMIQKQLGKDVADVHDIAKSSKEDLEAYDILLLGIPTWYYGEAQCDWDDFFPTLEEIDFNGKLVALFGCGDQEDYAEYFCDALGTIRDIIEPRGATIDADWPTAGYHFQASKGLADDDHFVGLAIDEDRHPELTADRVEKWVKQISEELHLDEILNA
Low-potential electron donor to a number of redox enzymes.
Q83S80
Q3AGL2
RL9_SYNSC
50S ribosomal protein L9
unclassified Synechococcus
MPKRVQIVLNEDILSLGMDGDLVEVAPGYARNFLLPFGKAVPLTPAVMKQVEHRRAKEAERQAALKQEAVDFKTALSTIGRFTVKKQTGEDNVLFGTVTNGDVAEAIETATKKEIDRRDIVVPEIHRTGKYTVTVKLHSEVTAEINLEVVGY
Binds to the 23S rRNA.
Q3AGL2
Q4USQ8
PYRH_XANC8
Uridine monophosphate kinase
Xanthomonas
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLATVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDKDPKKHSDAVRYDSLTYDEVIMQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGAQIGTLVQGRS
Catalyzes the reversible phosphorylation of UMP to UDP.
Q4USQ8
C0HL02
BR2RJ_PELRI
Brevinin-2Rj
Pelophylax
GIFLDKLKNFGKDVAGILLKKASCALSGQC
Antimicrobial peptide.
C0HL02
Q32M08
DUS4L_MOUSE
tRNA-dihydrouridine synthase 4-like
Mus
MRSDSLPTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIIAADFVRSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAALLVCPYANGIDINCGCPQRWAMADGYGACLINKPELVHDMVRQVRNRVESPRFSVSIKIRIHDDLARTIDLCRKAEATGVSWITVHGRTVEERHQPVHYDAIKMIKENVSIPIVANGDIRSLKEAENVWQMTGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDISLELGTPFMCFHQHLMYMMEKITSRQEKRVFNALSSTSAVLDYLTDHYGDESLSKSL
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Q32M08
P34729
RAS1_PHYPO
Ras-like protein 1
Physarum
MTEYKLVIVGGGGVGKSALTIQLIQNHFIDEYDPTIEDSYRKQVTIDEETCLLDILDTAGQEEYSAMRDQYMRTGQGFLCVYSITSRSSFDEIASFREQILRVKDKDKVPMIVVGNKCDLEGERQVTTGEGQDLARSFGCPFMETSAKSRVNVEESFYQLVREIRKDSRTDTKGPGGKGGKKTLKCLLL
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
P34729
Q32NM1
CCNOB_XENLA
Cyclin-O protein B
Xenopus
MVTCSMRCTEEGLLGATLAFSSGKRKRDSVYSPGDATPGDRGEGEPKCPSVGTKKRAKYSRHRKQSLELRSCDSGVADLYETPSPSPVAPSPTHEPWDTCTPMYDGLGLQNFRDYGQDCYTFNKSLEDKFLAVNCLKNQPQIQAESRCKLISWLIPVHRHLNLGFESLCLTVNILDRFLACTPVASDCFQLVGVTSLLIASKQVETRPPRVKQLLALCCDAFSREQLCNLECIILLKLHFRLGAPTINFFLQHFSLLRVTNEESSDTELSETTKSVTVARGIAELSLADYAFNSYSPSLMAVCCLEIADRMLCHRNPIRARVSDYHESLIQECVGKIDLLVSLNQDSLHRLLPSQFAVKSINVDN
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of mcidas to promote mother centriole amplification and maturation in preparation for apical docking.
Q32NM1
Q3UQU0
BRD9_MOUSE
Bromodomain-containing protein 9
Mus
MGKKHKKHKAEWRSSYEDYTDTPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHREKKKKKKKKSEKEKHLDEEERRKRKEEKKRKREKEHCDSEGEADAFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKAALLGSEDPAAEEPVPEVVPVQVETTKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKKLGDGSLLYSVVNAPEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSASTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKMVDDLLDQITGGDHSRMIFQLKQRRSIPMRPADEMKVGDPLGESGGPVLDFMSMKQYPDVSLDVSMLSSLGKVKKELDHEDSHLNLDETARLLQDLHEAQAERGGSRPSSNLSSLSTASEREHPPPGSPSRLSVGEQPDVAHDPYEFLQSPEPAAPAKN
Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR).
Q3UQU0
B7KFZ3
DUT_GLOC7
dUTP pyrophosphatase
Gloeothece citriformis
MKLKVTKLEKAAILPKYVHSDDSGLDLSAIEDLEIPPGESQLVPTGIAIELPPNTEAQIRPRSGLALKHQITVLNTPGTVDEGYRGEIGVILINHGKNSFKVTRGMKIAQMVIAPVIRVEVEEVDHLSDTTRGSGGFGSTGLTSD
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
B7KFZ3
Q057X8
RS20_BUCCC
30S ribosomal protein S20
Buchnera
MANIKSSKKHISISEKRRKYNCSKRSMIKTFMKKVLFFIKEKNRIKAIKFFYIFQSLVDRYSLKKIIHINKASRYKSVLMNNIKKI
Binds directly to 16S ribosomal RNA.
Q057X8
Q26065
ACT_PLAMG
Actin, adductor muscle
Placopecten
MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMFPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Q26065
Q17Z21
PANC_HELAH
Pantoate-activating enzyme
Helicobacter
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFGANEDFSAYPRPLEKDLALCEKLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAMRKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHLVKDLLLDIEIVPCEIVRDSDHLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLEFCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q17Z21
Q136T8
NRDR_RHOPS
Transcriptional repressor NrdR
Rhodopseudomonas
MRCPNCNSLDTQVKDSRPTEDSSVIRRRRVCIACNFRFTTFERVQLRELTVIKRNGRRVPFDRDKLVRSVQISLRKRPVEPERVEQLVSAIVRELESSGEADISSETIGEIVMDHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSGEEEARPTLVRK
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Q136T8
B5ZB39
RS10_UREU1
30S ribosomal protein S10
Ureaplasma
MNQELRIRLESYDHRLLDDTVKTIVDISNSTGSKLRGPIPLPTKKEIFTILRSPHVNKSSREQFERRTHKRLIILENPQPKTMEALKRLSVPFGVEVTFKI
Involved in the binding of tRNA to the ribosomes.
B5ZB39
P70195
PSB7_MOUSE
Proteasome subunit Z
Mus
MAAVSVFQPPVGGFSFDNCRRNAVLEADFAKKGFKLPKARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLEIEVLEETVQTMDTS
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
P70195
Q5JGC8
SYT_THEKO
Threonyl-tRNA synthetase
Thermococcus
MRMLLIHSDYLEYEVKDKALKNPEPISDEQKTGRLDEVLAVFISVEKVDETNPDEVVEKAVKEIEDVASQIKAERIFVYPFAHLSSELAKPDVALEVLRKIEEKLREKGYEVKRAPFGYYKAFKLSCKGHPLAELSRTIVPEKAVSKEERNIALEKEEKELKSYWYILTPEGELIDVDKFDFTGHENLKKFVNYEIAKNRVADREPPHVRLMLEQELVDYEPGSDAGNLRYYPKGRLIKSLLEQYVTEKVIEYGAMEVETPIMYDFEHPALEKYLNRFPARQYVVKSGDKKFFLRFAACFGQFLIKKDATISYRNLPLRMYELTRYSFRREKSGELSGLRRLRAFTMPDMHTVARDLKQAMDEFKKQYKLSMEVLKGVGLTPEDYEVAIRFTRDFWEQNRDFIVELAKIIGKPVLIEMWDQRFFYFILKFEFNFVDNLDKAAALSTVQIDVENAERFGIKYYDEEGKERTPLILHCSPSGAIERVMYAILEKQAKLQEKGIKPMYPLWLSPIQVRVIPVSDEVMDYALYVAGKLEGAKIRVDVDDTGDRLNKKIRKAEKEWIPYIIVVGRNEKEQNTVTVRRRSDGRQVEMQLEDLIREIKGQTEGFPYKPRPLPLLLSRRPKFRG
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Q5JGC8
B3PBR5
ACCA_CELJU
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Cellvibrio
MNLNYLDFEQPIAELEGKIEELQLVGNSSDVNLADEVAKLREKSTKLTETIYSKLTAWDIVKVARHPQRPYASDYISRVFTEFDELHGDRHFGDDKAIIGGVGRLDGKPVMVIGEEKGRSVHEKVMRNFGMPRPEGYRKALRLMEMAERFKLPVLTLIDTPGAYPGIDSEERGISESIAQNLAVMSRLRTPIVCTVIGEGSSGGALAIGVGDHLNMLQYSTYFVISPEGCANIIWKTVAKAPEAAQAMGVTSKVLQDLGIVDETIPEPLGGAHRNVDEMARKLQERLVEQVEQLSREPIDALLERRYQRLMSYGN
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
B3PBR5
Q67KP1
NUOI2_SYMTH
NDH-1 subunit I 2
Symbiobacterium
MGVTNFFGEAWRTGKSIVTGLGITFREMMFRPAITVFYPEQRDDVPPWFRGIPVLKTDLRTGEYKCTSCMQCAQACPVNVITIEWHQDPETKKKVCDRFAIDMSRCMLCNFCVEACPFDSLVMGYDYELCKVNPENLVFEFEDLLRLGLKYSKAEEPGPKATRSSTPPWVFHGLTNATEDDIQDIHGYLGRPPLPKGYEPELKPQFRKPAEEAAEAQQAEAAGQPAAEPGKTNGEEAGQP
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q67KP1
P05066
PHR_YEAST
Photoreactivating enzyme
Saccharomyces
MKRTVISSSNAYASKRSRLDIEHDFEQYHSLNKKYYPRPITRTGANQFNNKSRAKPMEIVEKLQKKQKTSFENVSTVMHWFRNDLRLYDNVGLYKSVALFQQLRQKNAKAKLYAVYVINEDDWRAHMDSGWKLMFIMGALKNLQQSLAELHIPLLLWEFHTPKSTLSNSKEFVEFFKEKCMNVSSGTGTIITANIEYQTDELYRDIRLLENEDHRLQLKYYHDSCIVAPGLITTDRGTNYSVFTPWYKKWVLYVNNYKKSTSEICHLHIIEPLKYNETFELKPFQYSLPDEFLQYIPKSKWCLPDVSEEAALSRLKDFLGTKSSKYNNEKDMLYLGGTSGLSVYITTGRISTRLIVNQAFQSCNGQIMSKALKDNSSTQNFIKEVAWRDFYRHCMCNWPYTSMGMPYRLDTLDIKWENNPVAFEKWCTGNTGIPIVDAIMRKLLYTGYINNRSRMITASFLSKNLLIDWRWGERWFMKHLIDGDSSSNVGGWGFCSSTGIDAQPYFRVFNMDIQAKKYDPQMIFVKQWVPELISSENKRPENYPKPLVDLKHSRERALKVYKDAM
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
P05066
F0SLK8
NNRE_RUBBR
NAD(P)HX epimerase
Rubinisphaera
MSRVLSRDQSREVDQIAIEQFHLPGVVLMENAGRNCAELIRQLSPAGQILILAGKGNNGGDGFVIARHLHNAGLNVKLLVFANPEDYSGEAESNWRIITAMQLPAVSNATAADLSQALAELPESSLIVDALLGTGIRGQVRAPFDEIITAVNAYRDDHPHAIVFAVDVPSGLDCDTGLPCGVAIKADQTATFVMLKQGFVTGDGPEYTGTTHVIDIGIPPALLDRLTAE
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
F0SLK8
P0C299
TX32_ANDCR
Toxin Acra III-2
Androctonus
ADVPGNYPLNTYGNMYYCTILGENEFCKKICKVHGVSYGYCYNSYCWCEYLEGKDINIWDAVKNHCTNTNLYPNGK
Binds to sodium channels (Nav) and affects the channel activation process.
P0C299
Q035A8
RS11_LACP3
30S ribosomal protein S11
Lacticaseibacillus
MAGRKTTRKRRVRKNVESGVAHIHSTFNNTLVMITDPRGNAIAWSSAGALGFKGSRKSTPFAAQMAAEAAAKESMEHGMKSVEVAVKGPGSGREAAIRSLQATGLEVTAIRDVTPVPHNGSRPPKRRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q035A8
P93568
SSY1_SOLTU
Soluble starch synthase I
Solanum
MGSLQTPTNLSNKSCLCVSGRVVKGLRVERQVGLGFSWLLKGRRNRKVQSLCVTSSVSDGSSIAENKNVSEGLLLGAERDGSGSVVGFQLIPHSVAGDATMVESHDIVANDRDDLSEDTEEMEETPIKLTFNIIFVTAEAAPYSKTGGLGDVCGSLPMALAARGHRVMVVSPRYLNGGPSDEKYANAVDLDVRATVHCFGDAQEVAFYHEYRAGVDWVFVDHSSYCRPGTPYGDIYGAFGDNQFRFTLLSHAACEAPLVLPLGGFTYGEKCLFLANDWHAALVPLLLAAKYRPYGVYKDARSIVAIHNIAHQGVEPAVTYNNLGLPPQWYGAVEWIFPTWARAHALDTGETVNVLKGAIAVADRILTVSQGYSWEITTPEGGYGLHELLSSRQSVLNGITNGIDVNDWNPSTDEHIASHYSINDLSGKVQCKTDLQKELGLPIRPDCPLIGFIGRLDYQKGVDIILSAIPELMQNDVQVVMLGSGEKQYEDWMRHTENLFKDKFRAWVGFNVPVSHRITAGCDILLMPSRFEPCGLNQLYAMRYGTIPIVHSTGGLRDTVKDFNPYAQEGIGEGTGWTFSPLTSEKLLDTLKLAIGTYTEHKSSWEGLMRRGMGRDYSWENAAIQYEQVFTWAFIDPPYVR
Plays a minor role in starch synthesis in storage organs (tubers), but may contribute to the deposition of transient starch in chloroplasts of leaves.
P93568
P55992
GYRB_HELPY
DNA gyrase subunit B
Helicobacter
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPTSELEIIGKTKSAKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIISFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIGNNIKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHTQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
P55992
Q01771
STADS_BRANA
Acyl-[acyl-carrier-protein] desaturase
Brassica
MALKFNPLVSQPYKLASSARPPVSTFRSPKFLCLASSSSPALSSKEVESLKKPFTPPREVHLQVLHSMPPQKIEIFKSMEDRAEQNLLPHLKDVEKSWQPQDFLPDPASDGFEDQVKELRERARELPDDYFVVLVGDMITEEALPTYQTMLNTLDGVRDETGASPTSWAVWTRAWTAEENRHGDLLNKYLYLSGRVDMRQIEKTIQYLIGSGMDPRTENNPYLGFIYTSFQERATFVSHGNTARQAKEHGDLKLAQICGTIAADEKRHETAYTKIVEKLLEIDPDGTVVAFADMMRKKISMPAHLMYDGRDDNLFDNFSSVAQRLGVYTAKDYADILEFLAGRWRIESLTGLSGEGNKAQEYLCGLTPRIRRLDERAQARAKKGPKIPFSWIHDREVQL
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons Delta(9) and Delta(10) of the acyl chain.
Q01771
A7ZKF0
OPGC_ECO24
Glucans biosynthesis protein C
Escherichia
MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAEPSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHHKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR
Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
A7ZKF0
Q9SEV2
TBBN_GUITH
Nucleomorph beta-tubulin
Guillardia
MREIVHVQVGQCGNQIGAKFWEVISHEHGVDTNGTYFGNKDNQIEKIDVYYNEVSGNRFVPRAVLVDLEPGTMDSVRASNYGRLFRPDNFVFGQSGAGNNWAKGHYTEGAELIESAMDIIRKESEQCECLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNCTLSIHQLVENADEVFCIDNEALYDICFRTLKLVTPSYGDLNHLVSAVMSGITCSLRFPGQLNADLRKLAVNLVPFPRLHFFMVGFAPLGSRGSQQYRSMTVNDLTQQMFDSKNMMAACDPKNGRYLTAAAYFRGKISTKEVDDQMIEIQNKQSEHFVEWIPHNIKSSVCDIPPKGMKMSAAFIGNSTSIQELFKRVGEQFQAMFRRKAFLHWYTGEGMDEMEFTEAESNMQDLVSEYQQYQDAKMDNDAFEDQDLY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9SEV2
Q941L2
BAP1_ARATH
BON1-associated protein 1
Arabidopsis
MIYFGRSIDNHYTTMMTKTLEIDLRSAEGLKLNRRPIKKKTFAVVKIDEKCRKSNLDESRRSNPTWNYKSEMPINGNEQFIFIEVFYRTGSGHDKKIGEAKIPTNDFMGRYSPEGHLNFLSYRLRDEFGDKCGIVNLSILVKSDPTRDYGACSSQAAVTGLWRPRLETASIDGYGGRTVTGVPVWGLYQRQF
Negative regulator of cell death and defense responses. Exhibits calcium-dependent phospholipid binding properties.
Q941L2
Q01066
PDE1B_RAT
63 kDa Cam-PDE
Rattus
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVDVGDPNPDVVSFRSTWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Q01066
Q0K6P9
RPPH_CUPNH
(Di)nucleoside polyphosphate hydrolase
Cupriavidus
MLDREGFRPNVGIILLNARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGLLPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYKGQKQIWFLLRMAGRDCDIHLRATEHPEFDAWRWSHYWVPLEAVIEFKRDVYQLALTELSRFLNRHARVPLSPYGTHGPHGMHGRHGGPRSQALSRAQQAQQADADCNAEAAHATEHDSPATPVSTSRSTDD
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Q0K6P9
Q9ZNU6
DET1_SOLLC
tDET1
Solanum subgen. Lycopersicon
MFKTNNVTARLFERQICTPAPGTSIHRARRFYENVVPSYTIYDVECPDHSFRKFTDDGLYFVSFSRNHQDLVVYRPTWLTFSCKEEDCDTHDLPLKARKFESFFTQLYSVTLASSGELICKDFFLYMESNQFGLFATSTAQIHDAPPTGGAIQGVPSVEKITFHLLRLVDGAILDERVFHNDYVNLAHSIGAFLYDDLLAIVSLRYQRIHILQIRDSGDLVDVRAIGEFCREDDELFLNSNSQVLVNHVGNGFHHSLPQSETSFLSGIKQRLLSYIFRGIWNEADQTMRVQCLKKKFYFHFQDYIDLIIWKVQFLDRHHLLIKFGSVDGGVSRNADIHPSFFAVYNMETTEIVAFYQNSADELYFLFELFSDHFHVSSKSSLHMNFMSSHSNNIHALEQLRCTKNKATNFSQFVKKMMASLPCSCQSQSPSPYFDQSLFRFDEKLISAIDRHRQSTDHPIKFISRRQPNILKFKMKPGPEAGSTDGRTKKICSFLFHPILPLALSVQQTLFLQASVVNIHFRR
Component of light signal transduction machinery. Involved in fruit pigmentation and fruit nutritional quality. Acts as a negative regulator of fruit pigmentation. Probably acts by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes. Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5.
Q9ZNU6
P93703
C71C3_MAIZE
Protein benzoxazineless 5
Zea
MALQAAYEYLQQAVGHGAWSSTQTLTLLLIAVPTVLLLLASLAKSTSSSGRGKPPLPPSPPGTLPIVGHLHHIGPQTHISLQELVAKYGHNGFLFLRAGAVPTLIVSSPSAAEAVMRTHDHICASRPWSMASHILRYNTCDVAFSPLGEYWQQTRKLMNTHLLSNKKVYSFRHGREEEVCLVVDNLREAAAKSPSTAVDMSEVLAAYTNDVVSRSVLGSTHRKKGRNTLFREMTMTNVDLLVGFNLEYYIPRWPLTDLLFRLVCWKVTRHLKRWDALLEEVIHEHVEMRKLSGDKEKESDDFIDIFLSRYEEYGFTMDNVKSLLMNVFEAAIETSYLVLESAMAELMNHRRVMKKLQAEVRAYGAEKKLDMIREDDLSSLPYLKASMKEALRLHPPGPLLLPHYSTADCQIDGYHIPANPRVLVNGWAIGRDPAVWEKPEEFMPERFMRDGWDKSNSYSGQDFRYLPFGSGRRICPGANFGLATMEIMLANLMYHFDWEVPNEKEDGCWKVSMDEKFGLMLRRNELLYLVPRASS
Catalyzes the conversion of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) to 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA).
P93703
Q71ZX3
GCSPA_LISMF
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Listeria
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSKLASKNANTTEYASFLGAGVYSHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILISGAVHPESSNVLKTYATGQHIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLVSSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNLDKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNESLLDEGIIGGYDLGFYEEKYENHMLVAVTEMRTKEEIDAFVASLEGAK
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Q71ZX3
B5F8P1
GLPE_SALA4
Thiosulfate sulfurtransferase GlpE
Salmonella
MEQFECITVEEAYQKLRQGAAVLVDIRDPQSYAMGHAPQAFHLTNDTLGAFMRKHGFDTAVMVMCYHGNSSKGAAQYLLQQGYDAVYSIDGGFEAWHRRFPANVANGA
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
B5F8P1
Q9W6A7
OPSR1_DANRE
Red cone photoreceptor pigment 1
Danio
MAEHWGDAIYAARRKGDETTREAMFTYTNSNNTKDPFEGPNYHIAPRWVYNVATVWMFFVVVASTFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETLFASTISVINQFFGYFILGHPMCIFEGYTVSVCGIAALWSLTVISWERWVVVCKPFGNVKFDAKWASAGIIFSWVWAAAWCAPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVQSYMVVLMITCCIIPLAIIILCYIAVYLAIHAVAQQQKDSESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQFRVCIMQLFGKKVDDGSEVSTSKTEVSSVAPA
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Q9W6A7
Q1KXR9
RK22_HELAN
50S ribosomal protein L22, chloroplastic
Helianthus
MLNKRTTEVYALGQHISMSAHKARRVIDQIRGRSYEETLMILELMPYRACYPIFKLVYSAAANASSNMGSNEANLVISKAEVNKGTIMKRLKPRARGRSFAIQKPTCHITIVMKDISLDEYIDTDSIAWSQNKKKDTTMSYYDMYSNGGTWDKK
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q1KXR9
A2WWV5
ERG1_ORYSI
Rpp17
Oryza sativa
MAGSGVLEVHLVDAKGLTGNDFLGEIGKIDPYVVVQYRSQERKSSVARDQGKNPSWNEVFKFQINSTAATGQHKLFLRLMDHDTFSRDDFLGEATINVTDLISLGMEHGTWEMSESKHRVVLADKTYHGEIRVSLTFTASAKAQDHAEQVGGWAHSFRQ
May play a role in plant defense signaling. Isoform 2 binds to phospholipids in a Ca(2+)-dependent manner in response to pathogen elicitors.
A2WWV5
K9NBS6
AAM_RHOER
Acylamidase
Rhodococcus erythropolis group
MTEQNLHWLSATEMAASVASNNLSPNEIAEAMIQRVDAVNPSINAIVQFDREQVTRDAAELSRQQEAGEKLGPLHGVPFTIKDLTAVDGLPTTFGMKPMADNIATGNAVVVDRLRGAGGLFLGKTNTPESGYYGGTDNHLYGPTHNPWKLGNSAGGSSGGASAAVAAGLGPLAEGSDGAGSVRIPSALCGVVGLKPTTGVIPQTILAGRFYNWAYHGPITRTVADNALMLDIMAGPDNADPLSIERAETSYVEASKGDVKGLRVAWSPNLGLGHVDPEVLAVCLDALAAFEELGAQITEATPQWGNPSESMWSGIWVPGFASEYDLLDWENQRGEVDDYLIEIMHEAERLTGVDVGRADAFRGDMWDTWTTFMNDYDVLVSPTLASATFPLRQFAPSWLEGASLREQLLDWLFTYPYNMLNNPAITVPAGFTADGRPVGLQIAARHRRDALVLRTAANFEAVRPWADKKPADSLVVA
Amidase with broad substrate specificity, catalyzing the hydrolysis of a wide range of N-substituted amides, and, to a lesser extent, the hydrolysis of non-substituted amides. Acid para-nitroanilides (4'-nitroacetanilide, Gly-pNA, Ala-pNA, Leu-pNA) are the best substrates for this enzyme. N-substituted acrylamides (isopropyl acrylamide, N,N-dimethyl-aminopropyl acrylamide, and methylene-bis-acrylamide), N-acetyl derivatives of glycine, alanine and leucine, and aliphatic amides (acetamide, acrylamide, isobutyramide, n-butyramide, and valeramide) can also be used as substrates but with less efficiency.
K9NBS6
O94609
UBA1_SCHPO
Poly(A)+ RNA transport protein 3
Schizosaccharomyces
MSNNMNIDQTDQNTIDEGLYSRQLYVLGHEAMKQMSQSNVLIIGCKGLGVEIAKNVCLAGVKSVTLYDPQPTRIEDLSSQYFLTEDDIGVPRAKVTVSKLAELNQYVPVSVVDELSTEYLKNFKCVVVTETSLTKQLEINDFTHKNHIAYIAADSRGLFGSIFCDFGENFICTDTDGNEPLTGMIASITDDGVVTMLEETRHGLENGDFVKFTEVKGMPGLNDGTPRKVEVKGPYTFSIGSVKDLGSAGYNGVFTQVKVPTKISFKSLRESLKDPEYVYPDFGKMMRPPQYHIAFQALSAFADAHEGSLPRPRNDIDAAEFFEFCKKIASTLQFDVELDEKLIKEISYQARGDLVAMSAFLGGAVAQEVLKATTSKFYPLKQYFYFDSLESLPSSVTISEETCKPRGCRYDGQIAVFGSEFQEKIASLSTFLVGAGAIGCEMLKNWAMMGVATGESGHISVTDMDSIEKSNLNRQFLFRPRDVGKLKSECASTAVSIMNPSLTGKITSYQERVGPESEGIFGDEFFEKLSLVTNALDNVEARMYVDRRCVFFEKPLLESGTLGTKGNTQVVVPHLTESYGSSQDPPEKSFPICTLKNFPNRIEHTIAWARDLFEGLFKQPIDNVNMYLSSPNFLETSLKTSSNPREVLENIRDYLVTEKPLSFEECIMWARLQFDKFFNNNIQQLLFNFPKDSVTSTGQPFWSGPKRAPTPLSFDIHNREHFDFIVAAASLYAFNYGLKSETDPAIYERVLAGYNPPPFAPKSGIKIQVNENEEAPETAANKDKQELKSIADSLPPPSSLVGFRLTPAEFEKDDDSNHHIDFITAASNLRAMNYDITPADRFKTKFVAGKIVPAMCTSTAVVSGLVCLELVKLVDGKKKIEEYKNGFFNLAIGLFTFSDPIASPKMKVNGKEIDKIWDRYNLPDCTLQELIDYFQKEEGLEVTMLSSGVSLLYANFQPPKKLAERLPLKISELVEQITKKKLEPFRKHLVLEICCDDANGEDVEVPFICIKL
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
O94609
Q8GYP8
FB310_ARATH
F-box protein At1g56610
Arabidopsis
MGFALVLIFLFGFYLFLMKSSSIFPQRPFTFLYDLWVLLLVLRFLFSLIQILILCLFNFRFVEMTSNNKKKKTELCDLPKCLAPHILSWLPTKTAVTVSLLFMKGWWRSEMKNLSSLKFSFSDDQEEEHFVRFVDQVLRQRGNRKLDSFSLTLNDEIDGGFVTHLVDYPLDNGVEKLKLSIYDIKGNFQLSSRVFSQATLVTLKLATNRSLIWINGDDVAAAHLPCLKTLWLDDVLVADVKVFVRLLSRCPILEELVMIDMKWHNWEACFVVSASLRRLKIVWTDYVEMDEYDRCPQSVLFDTPNVLYLEYTDHIAGQYPLLKFSSLIEAKIRLEMIDEKEEEDEGQEVIVGDNATAFITGITSVRKLYLYANTIQVLHHYFDPPIPEFVYLTHLTIQSDKELGWDAIPELLSKCPHLETLVLEGLFHLATDVCGDVCPCRRNMEQAISYLVKSPVTHLEIYEGVVGKKRGEVTEDAARFGEQVRWFLMRMLHLQQVKIYGQTEDSVTALYDIATELRRLEGKASPNVQISVLQA
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Q8GYP8
Q56RZ6
LTMM_EPIFI
Lolitrem B biosynthesis cluster 1 protein M
Epichloe
MTSDFKVIIVGGSVAGLSLAHCLEKIGVSFMVLEKGNQIAPQLGASIGILPNGGRILDQLGIFHSIEDEIEPLESAMMRYPDGFSFKSQYPQALHTSFGYPVAFLERQRFLQILYDKLKSKDCVFTNKRVVSIASGQDKVTAKTSDGAKYLADIVIGADGVHSIVRSEIWRHLKENSQISVLEAPNASIKHDYSCIYGISLNVPQIILGIQLNCLDDGVSIHLFTGKQSKLFWFVIIKTPQASFAKVEIDNTHTARCICEGLRTKKVSDTLCFEDVWSRCTIFKMTPLEEGVFKHWNYGRLACIGDAIRKMAPNNGQGANMAIEDACSLANILQKKISHGSIRDQDINSMFQEFSMAQRARTESVCAQSEFLVRMHANQGIGRRLLGRYLIPFLYDAPAGLSGFSISGATRIEFIDLPTRSLRGAWGKSWRGSWEFILQSLVYLRPKFRIVYALYLVAAAAFILYCLSSLFP
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of lolitrems, indole-diterpene mycotoxins that are potent tremorgens in mammals, and are synthesized by clavicipitaceous fungal endophytes in association with their grass hosts . The geranylgeranyl diphosphate (GGPP) synthase ltmG is proposed to catalyze the first step in lolitremB biosynthesis . LtmG catalyzes a series of iterative condensations of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), and farnesyl diphosphate (FPP), to form GGPP . GGPP then condenses with indole-3-glycerol phosphate to form 3-geranylgeranylindole, an acyclic intermediate, to be incorporated into paxilline . Either ltmG or ltmC could be responsible for this step, as both are putative prenyl transferases . The FAD-dependent monooxygenase ltmM then catalyzes the epoxidation of the two terminal alkenes of the geranylgeranyl moiety, which is subsequently cyclized by ltmB, to paspaline . The cytochrome P450 monooxygenases ltmQ and ltmP can sequentially oxidize paspaline to terpendole E and terpendole F . Alternatively, ltmP converts paspaline to an intermediate which is oxidized by ltmQ to terpendole F . LtmF, ltmK, ltmE and ltmJ appear to be unique to the epichloe endophytes . The prenyltransferase ltmF is involved in the 27-hydroxyl-O-prenylation . The cytochrome P450 monooxygenase ltmK is required for the oxidative acetal ring formation . The multi-functional prenyltransferase ltmE is required for C20- and C21-prenylations of the indole ring of paspalanes and acts together with the cytochrome P450 monooxygenase ltmJ to yield lolitremanes by multiple oxidations and ring closures . The stereoisomer pairs of lolitriol and lolitrem N or lolitrem B and lolitrem F may be attributed to variations in the way in which ring closure can occur under the action of ltmJ . While the major product of this pathway is lolitrem B, the prenyl transferases and cytochrome P450 monooxygenases identified in this pathway have a remarkable versatility in their regio- and stereo-specificities to generate a diverse range of metabolites that are products of a metabolic grid rather than a linear pathway .
Q56RZ6
B9L8Z0
DNAK_NAUPA
Heat shock protein 70
Nautilia
MGKVIGIDLGTTNSAMAYYDGKDAKIIANKEGRNTTPSVVAFTDKGEVLVGEPAKRQAITNPERTIYSVKRIMGMMCNEPKAQEAKKHVQYKIVDKNGACAVEVDGKVYTPQEISAKILMKLKKDAEEFFGEEVTEAVITVPAYFNDSQRKATQEAGKIAGLNVLRIINEPTAAALAYGLDKKGEEKILVYDLGGGTFDVTVLEIGDGTFQVLATDGNAFLGGDDFDNRIVDWLISEFKAETGIDLSQDKMALQRLKDAAEQAKKELSTKEETEINLPFITADASGPKHLVKKLTRAKFEAMIDDLLQETLRHIDTALEDAGLSKDEIDEIVMVGGSTRIPKVQELVSNYFNGKKLNKSVNPDEVVALGAAIQAGVLKGDVKDVLLLDVTPLSLGIETLGGVMTKIIEKGTTIPVKKSQVFSTAEDNQTAVTIHVLQGEAELAKDNKSLGQFNLEGIPPAPRGVPQIEVTFDIDANGVLNVSAKDKTSGKEQKITITGSSTLSEEEIERMVREAEEANRKEKARIEAIKARNELDAVAYQAEKFINDNKDKLGDVSALEAKIKEAKELIEQQSEDKAKIEALKNEINTELQNVAQNMAQQQQAQGGAQQQNQNKGGDDDVIDAEVE
Acts as a chaperone.
B9L8Z0
Q74JU6
EFTU_LACJO
Elongation factor Tu
Lactobacillus
MAEKEHYERTKPHVNIGTIGHVDHGKTTLTAAITTVLAEDGLAQAEDYSQIDAAPEEKERGITINTAHVEYETKNRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVQYIVVFLNKVDLVDDPELIDLVEMEVRDLLSEYDYPGDDVPVIRGSALKALEGDPEQQDVIRKLMETVDEYIPTPERDTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLTDKIEKSTVTGLEMFHKTLDLGEAGDNVGVLLRGIDRDQVERGQVLAAPGSIQTHKNFKGQVYILNKDEGGRHTPFFSDYRPQFYFHTTDVTGKIELPEGTEMVMPGDNVEFTVELIKPVAIEKGTKFTIREGGKTVGAGQVTEILD
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q74JU6
B3H2C0
UBID_ACTP7
Polyprenyl p-hydroxybenzoate decarboxylase
Actinobacillus
MKYKDLREFLTLLEGQGELVRIKQEIDPYLEMAEISDRTLRKGGPAILFENPKGYRMPVLCNLFGTPKRVALGMGQEDTHALRELGKLLAFLKEPEPPKGFKELIGQLPQWKQVLNMPSKVLGKADCQQVVLSGDEVDLHKLPIMHCHQGDVAPLVTWGLTITQGPYKKRQNLGIYRQQLIGKNKLIMRWLSHRGGALDFHEWKEANPDKPFPVSVAIGADPATILAAVTPIPDTLSEYAFAGLLRGQKTEVTKSISNDLEIPASAEIVLEGYIDPNETALEGPYGDHTGYYNEQEYFPVFTVTHITMRRDAIYHSTYTGRPPDEPAVLGEALNEVFIPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWKDVIWAITTRCDPSRDTTLIDHTPIDYLDFASPIAGLGSKMGIDATNKWPGETSREWGTPIKKDPNVVKLVDEIWDQLGL
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
B3H2C0
Q2NJ19
EFG_AYWBP
Elongation factor G
Candidatus Phytoplasma asteris
MARQFSLEKTRNIGIIAHIDAGKTTTTERILFHTGKIHKIGETHDGASQMDWMEQEQERGITITSAATTAFWKNHRINIIDTPGHVDFTVEVSRSLRVLDGAVTVIDAQAGVEPQTETVWRQASEYKVPRVIFVNKMDKVGADFAYAIETLKQRLGVHASAIQWPIGSENDFNGIIDLVEMNAFEYDNTSQETGKVVSIPSDLESITQTKRKELIETLSTLDEELMIYYLEEKPISSEMLKNSIRKATLQASFFPVLCGSSFKNKGVVKMLDAVVDYLPAPCDVAAIVGFDSDNQEIVRTGLDEEPFTALAFKVMTDPYVGKLTFFRIYSGSVKAGSYVTNTTKGTKERFGRLLQMHANSREEVKEAYTGDILAVVGLKATTTGDTLASEGQTIILESMNFPEPVIEIAVEPKTKADQDKMGIALAKLAEEDPTFKVFSNHETGQTIIAGMGELHLDIIIERLKREFKVQANVTEPQVAYRETITQETETEGKFIRQSGGRGQYGHVWMRFEPNPGKGFEFVNKIVGGVVPREYVPAVQKGIQEALAGGILAGYQIIDVKATLFDGSYHDVDSSEIAFKIAASMALKETKTKGNPVILEPIMDVEVVTPNDYVGNVIGDLTSRRGRLENQESRTNAVAIRAFVPLSEMFGYATVLRSNTQGRATFIMQFAKYEKAPKSITEEIIKKRA
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Q2NJ19
B3Q9W8
GATC_RHOPT
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Rhodopseudomonas
MSVDAATVRRIAHLARIAVTEDEVPHLQGELNAMLAFVEQLSEVDVDGVEPMTSVTPMQMKKRADVVNDGEIADQVVANAPSTEDHFFLVPKVVE
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
B3Q9W8
A8G7H8
RL9_PROM2
50S ribosomal protein L9
Prochlorococcus
MAKRVQLALTESIASLGKEGDLVEVAPGYARNFLLPYGKAMNVTPAVLKQIERKKEKEKIAADKLKQEALDFQTALSTIGRFTIKKQVGEDGVLFGTVTNGDVAEAIEEATKKEIDRRNITVPDIHNLGSFTAKIKLHPEVNAEVNIEVTS
Binds to the 23S rRNA.
A8G7H8
Q9PH24
LEXA_XYLFA
LexA repressor
Xylella
MSLSDIQQAILSLITNHINADGVSPSQTEIARAFGFKGVRAVQHHLDVLEQQGMIRRVPRQARGIRLKHLTEVDETALALQSEDVLRLPVLGRVAAGQPIGADIGEGRVVLLDRVFFSPAPDYLLRVQGDSMRDEGIFDGDLIGVHRTQDAHSGQIVVARIDDEITVKLLKISKDRIRLLPRNPDFAPIEVRSDQDFAIEGLYCGLLRPNR
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Q9PH24
A0A193H329
CZS8_CRUCA
Cruzioseptin-8
Cruziohyla
MAFLKKCLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVIKHVGKAAGKAALNAVTEMVNQGEQ
Has antimicrobial activity.
A0A193H329
P62150
CALM_ORYLA
Calmodulin-A
Oryzias
EQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFV
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
P62150
B7V0S0
TRPA_PSEA8
Tryptophan synthase alpha chain
Pseudomonas
MSRLQTRFAQLKQENRAALVTFVTAGDPDYASSLEILKGLPAAGADVIELGMPFTDPMADGPAIQLANIRALDGGQTLARTLQMVREFRSGESETPLVLMGYFNPIHHYGVERFIAEAKEVGVDGLIVVDLPPEHNEDLCHPAQAAGLDFIRLTTPTTGDQRLPTVLEGSSGFVYYVSVAGVTGANAATLEHVEEAVARLRRHTDLPIGIGFGIRSAEHAAAVARLADGVVVGSALIDRIAKARDNAQAVKDVLALCGELAEGVRNAR
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B7V0S0
A8LC57
RS10_FRASN
30S ribosomal protein S10
unclassified Frankia
MAAQKIRIRLKAYDHEVIDSSARKIVETVTRTGAQVAGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL
Involved in the binding of tRNA to the ribosomes.
A8LC57
Q8PYQ9
PURA_METMA
IMP--aspartate ligase
Methanosarcina
MFTIITGAQFGDEGKGKIVDLLAKDYDVVARFQGGNNAGHTVKVGDEVYKLHLIPSGILLDARVLIGPGVVLNPEVLAEEIEMFEKHGVKVNSEKLGVDAKTSIIMPYHIELDGLREASRETKIGTTKRGIGYAYIDKVARDEIRMAELVDKERFLARLEELAPQKEKEIEAMGGDPRIVRDPELIKRYLELGEQFAAYITDVSREINQALDEGKNVMAEAAQGTHLDVIHGTQKFVTSSSTIAGSACANLGVGPTRVDNVIAIVKAYITRVGEGPLPTELIGELGERIQKAGGEFGTTTGRGRRCGWFDLPLLKKAIALNGYTEISLTKLDVLTGLDPLRSAQVMSIKGKNWTILRNLRKTSRHAALCMKTCQDGKKN
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q8PYQ9