accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
P15223
SCX1_CENNO
Toxin II.14
Centruroides
MNSLLMITACFVLIGTVWAKDGYLVDAKGCKKNCYKLGKNDYCNRECRMKHRGGSYGYCYGFGCYCEGLSDSTPTWPLPNKTCSGK
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
P15223
Q9ZHZ4
RBL2_HALNC
Form II RuBisCO
Halothiobacillus
MDQSARYADLSLKEEDLIAGGKHILVAYKMKPKAGHGYLEASAHFAAESSTGTNVEVSTTDDFTKGVDALVYYIDEATEDMRIAYPMDLFDRNVTDGRMMLVSVLTLIIGNNQGMGDIEHAKIHDIYFPERAIQLFDGPSKDISDMWRILGRPIENGGYIAGTIIKPKLGLRPEPFAAAAYQFWLGGDFIKNDEPQGNQVFCPLKKVLPLVYDSMKRAQDETGQAKLFSMNITADDHYEMMARADFGLETFGPDADKLAFLVDGFVGGPGMITTARRQYPNQYLHYHRAGHGMITSPSAKRGYTAFVLAKISRLQGASGIHVGTMGYGKMEGEGDDRNIAYMIERDEAQGPVYFQKWYGMKPTTPIISGGMNALRLPGFFENLGHGNVINTAGGGSYGHIDSPAAGAISLKQAYECWKAGADPIEFAKEHKEFARAFESFPKDADAIFPGWREKLGVHK
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
Q9ZHZ4
P20853
CP2A7_HUMAN
Cytochrome P450 IIA4
Homo
MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
P20853
Q733D6
PHNC_BACC1
Phosphonates import ATP-binding protein PhnC
Bacillus cereus group
MIEFRNVSKVYPNGTKGLNHINLKIQKGEFVVMVGLSGAGKSTLLRSVNRLHEITEGEIMIEGESITAAKGKGLRRMRRDIGMIFQSFNLVKRSTVLKNVLAGRVGYHSTLRTTLGIFPKEDLELAFQSLKRVNILEKAYARADELSGGQQQRVSIARALAQEAKIILADEPVASLDPLTTKQVLDDLKKINEDFGITTIVNLHSIDLARQYATRIIGLHAGEIVFDGLVEEATDEKFAEIYGDVAQKSELLEVAVK
Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.
Q733D6
A8LQ30
BCHL_DINSH
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein
Dinoroseobacter
MSPLDTAPPVLKGEDGEGSVQVHQDDSMKIEGAKVFSVYGKGGIGKSTTSSNLSAAFSKLGKRVLQIGCDPKHDSTFTLTGSLVPTVIDILKEVDFHAEELRPEDFVFEGFNGVKCVEAGGPPAGTGCGGYVVGQTVKLLKQHHLLEDTDVVIFDVLGDVVCGGFAAPLQHADRALIVTANDFDSIYAMNRIIAAVQAKSKNYSVRLAGCVANRSRETDEVDRYCKTVGFNRIAHMPDLDAIRRSRLKKKTLFEMEDAEDVVQVRKEYIRLAETLWNGTEPLAPAPLPDREIFELLGFD
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
A8LQ30
B2S6E8
COBQ_BRUA1
Cobyric acid synthase
Brucella
MARAIMFQGTGSDVGKSVLVAGLCRVARNRGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALACGVPSSVHMNPVLLKPQTDMGSQLIVQGQVRGEARGRYYQELKPQLMAAVMESFAKVGDGADLVLVEGAGSPAEINLRAGDIANMGFATHADVPVVLVGDIDRGGVIASLVGTHTILPQEDRAMVRGFLINKFRGDISLFDDGLAAITRFTGWRSFGVVPWLKAVSRLPAEDSVVLERAVRGDKKALIVAVPMLPRIANFDDLDPLKAEPAVEVVMVPPGSSLPADAGLVVLPGTKSTIADLLALRENGWDRELVAHVKRGGHVLGICGGFQMLGRRISDPAGIEGNVRDIEGLGLLDIETMTEPEKVVRNVEAVSLLHDEPLEGYEIHIGRTSGPDMARPFARIGDHDDGAVSPDGRIMGTYLHGIFSADRFRHHFLRALGVEGGQMNYRESVEEALGELAEGLEASLDIDGLFALA
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
B2S6E8
B5FTK8
NUDL_SALDC
Uncharacterized Nudix hydrolase NudL
Salmonella
MDTSRLTLDHFLSRFQLLRPQMTHKTLNQRQAAVLIPVVRRPQPGLLLTQRAIHLRKHAGQVAFPGGAVDSTDASLIAAALREAQEEVAIPPQAVEVIGVLPPVDSVTGFQVTPVVGIIPPNLPWRASEDEVSAVFEMPLAQALQLGRYHPLDVYRRGNSHRVWLSWYEHYFVWGMTANILRELALQIGVKP
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
B5FTK8
A7FLJ3
NQRF_YERP3
NQR-1 subunit F
Yersinia
MEIILGVVMFTLIVLALTVMILFAKSKLVNTGDITVEINEDEDKSFTAPAGDKLLNMLSSHGIFVSSACGGGGSCGQCRVTIKEGGGDILPTELSHISKREAKEGCRLACQVNVKQNLKIELPEEIFGVKKWTCEVISNDNKATFIKELKLKIPDGDVVPFRAGGFIQIEAEPHTVKYADFDVPTEYRGDWDKFNLFRFESVVTEPTVRAYSMANYPEEHGIILLNVRIATPPPSVPDAPPGIMSSYIWSLKPGDKVVISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLHSKRKISFWYGARSRREMFYEEDFDQLQAENDNFRWHVALSDPQPEDNWTGYTGFIHNVLLENYLKDHPAPEDCEFYMCGPPMMNAAVIKMLKDLGVEDENIMLDDFGG
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
A7FLJ3
P46467
VPS4B_MOUSE
Suppressor of K(+) transport growth defect 1
Mus
MASTNTNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKKKEKKPQKPVKEEQSGPVDEKGNDSDGEAESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFGQEG
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses).
P46467
B0KCI8
RL11_THEP3
50S ribosomal protein L11
Thermoanaerobacter
MAKKVAAVVKIQLPAGKATPAPPVGTALGPHGVNIMAFCKEFNERTAKDAGLIIPVVITIYADRSFSFITKTPPAAVLLKKAAGIESGSPQPNKQKVGKITREQLREIAEIKMKDLNASDIEAAMRMIAGTARSMGIEIV
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
B0KCI8
P0C7N5
OR8U9_HUMAN
Olfactory receptor 8U9
Homo
MTQINCTQVTEFILVGLTDRQELKMPLFVLFLSIYLFTVVGNLGLILLIRTDEKLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNSISFNACAAQLGCFLAFMTAECLLLASMAYDRYVAICNPLMYMVVMSPGICIQLVAAPHSYSILVALFHTILTFRLSYCHSNIVNHFYCDDMPLLRLTCSDTRFKQLWIFACAGIMFISSLLIVFVSYMFIISAILRMHSAEGRQKAFSTCGSHMLAVTIFYGTLIFMYLQPSSSHALDTDKMASVFYTVIIPMLNPLIYSLQNKEVKEALKKIIINKN
Odorant receptor.
P0C7N5
Q6NTP2
IREB2_XENLA
Iron-responsive element-binding protein 2
Xenopus
MTENPFHYLVETLSGTSDKTFFNVSKLKATEYDSLPYCIRVVLEAVVRNCDGVLVKEQDAFNILNWKTKCEFKEIPFLPARVMLQDFTGIPAMVDFAAMRDAISKFGKDPKQVNPACPTDLIADHSLQLDFTKCIAAQNVSGLPAVETHRPTTTPGKTPGRKAQCRSQGGCKGACDLGAANGSSREQIENTPMLCPFHLQPIAEPETALKSLEIEFNRNKERLQFFKWCSKAFQNVAVIPPETGTVHQVNLEFLSRVVMEEKGCIYPDSVLGTDSHTTMVNGLGILGLGVGGIESEAAMLGVPITLTLPEVVGCELTGTINPIATSIDVVLSITKHLKQAGVAGTFVEFFGNGVSQLSVADRTTIANMCPEYGATVAFFPVDSVTLQHLKQTGVDLQCVKTFENYLKAVKLLRQENVQQPLYSKVLQINLNSIVPYVSGPKRPQDRISVMDMKKDFETCLKEKTGLKGFQIPEEKQNIMVPVTYGNSEYSLSHGCVVIAAVTSCTNNCNPSVMLTAGLLAKKAVEAGLTVKPYIKTSLSPGSGTVTYYLSASGVLPYLSKLGFDIIGYGCARCVGNTNPLPESIVTAIKEGELVACGVFSGNKHFEGNRCSCVCANYLASPPLVVAYALAGTVNIDLQTEPLGENAQGKKIFLQDIWPSREEVLEVEETLVIPSMFSELKLKIEKQNTRWNLLDAPESTLFPWDLRSTYIRSPPFFHKLEKIPPPIQPIERAYVLLYLGDSVTTDHMSPAGSIPRTSPAAKYLMQKNLVPREFNSYGARRGNDAVMTRGTFANMKLFNKLVGKTGPKTIHLPSGQTMDVFDAAELYQRSEIPLIIIAGKKYGLGNSRDWAAKGPFLLGVRVVIAESYEKIHKDHLVGMGIAPLQFLSGENAETLGLSGKEQYSLSLPVDLTPGHKVEIKTNTGKIFHVIAAFDNEAEVTLYKHGGILSYVARKYL
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Q6NTP2
Q5FAF7
SYY_NEIG1
Tyrosyl-tRNA synthetase
Neisseria
MSVIQDLQSRGLIAQTTDIEALDALLNEQKIALYCGFDPTADSLHIGHLLPVLALRRFQQAGHTPIALVGGATGMIGDPSFKAAERSLNSAETVAGWVGSIRSQLTPFLSFEGGNAAIMANNADWFGSMNCLDFLRDIGKHFSVNAMLNKESVKQRIDRDGAGISFTEFAYSLLQGYDFAELNKRHGAVLEIGGSDQWGNITAGIDLTRRLNQKQVFGLTLPLVTKSDGTKFGKTEGGAVWLNAKKTSPYQFYQFWLKVADADVYKFLKYFTFLSIEEIGVVEAKDKASGSKPEAQRILAEEMTRLIHGEEALAAAQRISESLFAEDQSRLTESDFEQLALDGLPAFEVSDGINAVEALVKTGLAASNKEARGFVNAKAVLLNGKPAEANNPNHAAERPDDAYLLIGEYKRFGKYTILRRGKRNHALLVWK
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Q5FAF7
Q0TB40
NEPI_ECOL5
Purine ribonucleoside efflux pump NepI
Escherichia
MSEFIAENRGANAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGVALGGFWAISASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
Q0TB40
O44390
ACO11_TRINI
Acyl-CoA Delta-11 desaturase
Trichoplusia
MAVMAQTVQETATVLEEEARTVTLVAPKTTPRKYKYIYTNFLTFSYAHLAALYGLYLCFTSAKWETLLFSFVLFHMSNIGITAGAHRLWTHKTFKAKLPLEIVLMIFNSLAFQNTAITWAREHRLHHKYSDTDADPHNASRGFFYSHVGWLLVKKHPDVLKYGKTIDMSDVYNNPVLKFQKKYAVPLIGTVCFALPTLIPVYCWGESWNNAWHIALFRYIFNLNVTFLVNSAAHIWGNKPYDKSILPAQNLLVSFLASGEGFHNYHHVFPWDYRTAELGNNFLNLTTLFIDFCAWFGWAYDLKSVSEDIIKQRAKRTGDGSSGVIWGWDDKDMDRDIKSKANIFYAKKE
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
O44390
P67702
HIGA_ECOL6
Antitoxin HigA
Escherichia
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGGIAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin.
P67702
Q9D676
CLC2G_MOUSE
Osteoclast inhibitory lectin-related protein 1
Mus
MNITRASLPMLNTTCSCRREKWNFLGRYEGTFDYWIGLHRASSKHPWMWTDNTEYNNMFVYHMNAQCLKKPEEGESSPGTGGVHSYKILQRNSLRAISPESSAKLYCCCGVIMVLTVAVVALSVALPATKTEQILINKTYAACPKNWIGVGNKCFYFSEYTSNWTFAQTFCMAQEAQLARFDNEKELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNMIPIQGVETCAYLSGNGISSSRHYIPRIWICSKLNNYSLHCPTPVPV
Inhibits osteoclast formation.
Q9D676
Q5NRC5
LEUC_ZYMMO
Isopropylmalate isomerase
Zymomonas
MTKNPRTLYEKIWDAHIVERREDGSALIYIDRHLVHEVTSPQAFEALRQAGRPLRRPDRTLAVPDHNVPTTARVDSEGHLLPIADPQSAKQLAALAKNAPEFGVRYISATDPEQGIVHVVGPEQGFTLPGTTLVCGDSHTAAHGALGALAFGIGTSEVEHVMATQTLILTPAKTMEVRVEGKLSPDVSAKDLILHIIHSLGTAGGTGYAIEYTGEAIRNLSIEERLTVSNMSIEAGARTGLIAADEKTFAYLFGRPMAPKGADWEKAVQWWKSLATDKGAVYDKTVIIKAEDVQPSVTWGTSPEDVVPITGVVPDPASFADPAKQAAARRSLEYMGLEPGQKMEGLAVENVFIGSCTNSRIEDLRAAASVVWGRHVADNVKQALVVPGSGLVKRQAEAEGLDEVFKAAGFEWREPGCSMCLAMNPDKVPAGERCASTSNRNFVGRQGPGARTHLVSPAMAAAAAVTGHLTDLRHLEPVKMGEKA
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Q5NRC5
Q02721
TO6BL_YEAST
Meiotic recombination protein REC102
Saccharomyces
MARDITFLTVFLESCGAVNNDEAGKLLSAWTSTVRIEGPESTDSNSLYIPLLPPGMLKIKLNFKMNDRLVTEEQELFTKLREIVGSSIRFWEEQLFYQVQDVSTIENHVILSLKCTILTDAQISTFISKPRELHTHAKGYPEIYYLSELSTTVNFFSKEGNYVEISQVIPHFNEYFSSLIVSQLEFEYPMVFSMISRLRLKWQQSSLAPISYALTSNSVLLPIMLNMIAQDKSSTTAYQILCRRRGPPIQNFQIFSLPAVTYNK
Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May mediate the interaction between SPO11 subunits during meiosis. Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division. Not required for mitosis and mitotic DNA repair mechanisms.
Q02721
A1U2U9
RLMD_MARN8
23S rRNA(m5U1939)-methyltransferase
Marinobacter
MSKRRRKVLPKEPVRCEIETLSHDGRGIARADGKTQFVDGALPGETVMAKMVRTRSRFDELRTTEVLEAAPDRQQPPCEFADLCGGCSLQHMSADAQIRFKENTLREHFAHFGGIEPEQWVAPMRSPDSLGYRRKARLGVRYVKARESVLVGFREKRNSFLTDIDRCVVLDPRIGERIEPLRELLHGMAAFDRIAQVEVACGDDTAAMVFRNMDDLVPDDREKLIAFGQAHDLHIYLQPKGPDTVHRIWPESGGRDDERLTYRMDEFDLTMAFHPMDFTQVNAGINRNMVHRAVEWLDVQPGERVLDLFCGLGNFTLPLARKGGQVVGVEGDDAMVVRGRENARLNDLSNVEFHGADLHGDFTGQSWAKEGFDKILIDPPRSGAEEICKYLTAFGANRIVYVSCNPATLARDAGVMVRNGYRLVQAGVMDMFPHTTHVESIALFERSAD
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
A1U2U9
Q0TMS8
ECFA2_CLOP1
Energy-coupling factor transporter ATP-binding protein EcfA2
Clostridium
MSIKIENLNHIYMPKTPFEKIALNNINCEIEDGEFVALIGHTGSGKSTFIQHLNGLLSPTSGNIIVDGVNIADKKVKLSDIRKKVGLVFQYPEYQLFEETIEKDIEYGPRNLGISEEEISKRVKKSMEMVGLDYETYKDKSPFDLSGGQKRRVAIAGVIAMEPKVLILDEPTAGLDPKGREDILAQIRLLHKEYGMTIIMVSHSMEDVAKIADRVIVMNSGEIVLDGKIAEVFKEVETLEKIGLAVPQVTYLIRELRNKGFNISEEIFTISQAKEALLEIIRNNN
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q0TMS8
Q6L0A8
MPTA_PICTO
GTP cyclohydrolase IV
Picrophilus
MIELKDVQGFRPDYEIPIKRAGIKSFKRRVKLNYNNESFDSYVDVSISVSLNPDRKGLDMSRTIESVRSSYNLNDVAYDIYNDLFSRINYSSSGYVNVSFDFYYNNKIYPVSLIAEGDKNDVKRYVEVSAEGMTVCPCAMETIRSIMLYDYNVSYGDIGISHNQRNKASLKIQYIKDAHLERLIDILESSFSYPVRNMLKRYDEGKMIIEAHKRPKFVEDVVREIAYKAAFMEPEMNLYMDVRSESFESIHPHNAYAEIEDYTANIRSYLKNR
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
Q6L0A8
A2SKL7
ERPA_METPP
Putative iron-sulfur cluster insertion protein ErpA
Methylibium
MSAVAEHIATQMPAPIVFTDSAAGKVKELVEEEGNPELKLRVFVQGGGCSGFQYGFTFDEIVNDDDTKMEKNGVMLLIDAMSLQYLVGAEIDYKEDLEGAQFVIKNPNATTTCGCGSSFST
Required for insertion of 4Fe-4S clusters.
A2SKL7
Q5L8D5
RS4_BACFN
30S ribosomal protein S4
Bacteroides
MARYTGPKSRIARKFGEGIFGADKVLSKKNYPPGQHGNSRKRKTSEYGIQLREKQKAKYTYGVLEKQFRNLFEKAATAKGITGEVLLQMLEGRLDNIVFRLGIAPTRAAARQLVGHKHITVDGQVVNIPSYAVKPGQLIGVRERSKSLEVIANSLAGFNHSKYAWLEWDEASKVGKLLHIPERADIPENIKEHLIVELYSK
With S5 and S12 plays an important role in translational accuracy.
Q5L8D5
Q9CA40
NUDT1_ARATH
NADH pyrophosphatase
Arabidopsis
MSTGEAIPRVAVVVFILNGNSILLGRRRSSIGNSTFALPGGHLEFGESFEECAAREVMEETGLKIEKMKLLTVTNNVFKEAPTPSHYVSVSIRAVLVDPSQEPKNMEPEKCEGWDWYDWENLPKPLFWPLEKLFGSGFNPFTHGGGD
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Its substrate specificity is unclear. In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate. Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments. Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine.
Q9CA40
Q6N4T7
RL23_RHOPA
RRP-L23
Rhodopseudomonas
MKSIDPRHYDVIVAPVVTEKSTMASEHNKVVFKVQGGATKPQIKEAVEKLFDVKVKSVNTLVRKGKTKAFRGTFGTQSDVKRAVVTLEEGHRIDVTTGL
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Q6N4T7
P11398
PYR1_MASLA
Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod
Mastigocladus
MAITAAASRLGTEPFSNAAKIELRSDASREEVEAVINAVYRHVLGNDYIMASERLVSAESLLRDGNLTVREFVRSVAKSELYKKKFFYNSFQTRFIELNYKHLLGRAPYDESEIVFHLDLYQNKGYDAEIDSYIDSVEYQNNFGDNIVPYYRGFETQPGQKTVGFNRMFRLYRGYANSDRAQIEGTKPRLARELATNKASSIVGPSGSNPAWGYRPSVDITPRKTLGNAVGENDRVYRIEVTGVRSPGYPSVRRSSYAIIVPYERLSEKIQQIHKLGGKIVSITSA
Rod linker protein, associated with phycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
P11398
Q7U8C3
DXR_PARMW
2-C-methyl-D-erythritol 4-phosphate synthase
Parasynechococcus marenigrum
MLGSTGSIGTQTLQIAEEFPEQFRVVALTAGQNLDLLVQQIQRHQPELVALANADLLPELQQRLDALGTDRKRPQLVGGPDGLNIAASWESADLVVTGIVGCAGLLPTLAAVRAGKDLALANKETLIAAGPVVLPELKKSGSRLLPADSEHSAIFQCLQGTPWAENARLSTGVPTPGLRRIQLTASGGAFRDWKAEDLENATVADATSHPNWSMGRKITVDSASLMNKGLEVIEAHYLFGLDYDHIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPSRLETPWRRLDLTEVGQLSFRAPDPAKYPCMQLAYAAGRAGGTMPAVMNAANEEAVAQFLEEKIHFLDIPVVIEAACERHKADLIAHPQLEDVLAVDQWARMAVREQVKRGTTRVPLAALAA
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Q7U8C3
Q9U2G5
MRP7_CAEEL
Multidrug resistance protein mrp-7
Caenorhabditis
MLSSFCGDGHPFSTGLPNVSICAQHTVLVWVPAAFFLLTLPFLSAQCHLTAQRFARLPFSAHFIIKLLLVAFLAANSLATWCYVLFSKNSYAAAYYVYPGLWVLVWTGTFLVHLIRLRCGLVSSGIQHVTSLIFLLCGAPEFYQWIRMENSNSFPNDLTTTDSAQFLSIAYLSWYSALILYTFSLCFADPRGAKTDDEKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEPKRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFISAKNAPFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIERSHNAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILRSFWLSAWSDEYDPDSPSAHPMAKGWRLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTNTPNEAPWRIEGREPAPGWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALMADKNSAFAKMVADAAEQDKHE
Negatively regulates cellular toxicity by mediating the export of environmental toxicants such as methylmercury out of the cell . Plays a role in inhibiting methylmercury-induced dopamine (DA) motor neuron degeneration . Not involved in Mn(2+)- or Al(3+)-associated toxicity .
Q9U2G5
P15802
AATA_PENCH
Acyl-coenzyme A:6-aminopenicillanic acid acyltransferase 29 kDa subunit
Penicillium chrysogenum species complex
MLHILCQGTPFEIGYEHGSAAKAVIARSIDFAVDLIRGKTKKTDEELKQVLSQLGRVIEERWPKYYEEIRGIAKGAERDVSEIVMLNTRTEFAYGLKAARDGCTTAYCQLPNGALQGQNWDFFSATKENLIRLTIRQAGLPTIKFITEAGIIGKVGFNSAGVAVNYNALHLQGLRPTGVPSHIALRIALESTSPSQAYDRIVEQGGMAASAFIMVGNGHEAFGLEFSPTSIRKQVLDANGRMVHTNHCLLQHGKNEKELDPLPDSWNRHQRMEFLLDGFDGTKQAFAQLWADEDNYPFSICRAYEEGKSRGATLFNIIYDHARREATVRLGRPTNPDEMFVMRFDEEDERSALNARL
Isopenicillin-N N-acyltransferase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic . AatA catalyzes the exchange of the alpha-aminoadipyl side chain of isopenicillin N for phenylacetic acid to yield penicillin . This step occurs in the peroxisomal matrix and the penM and paaT transporters are involved in the isopenicillin N and phenylacetic acid import into the peroxisome, respectively . The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA. The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase aatA to yield penicillin in the peroxisomal matrix (Probable).
P15802
A0S0B0
IL6_PAROL
Interleukin-6
Paralichthys
MASKHNADLSSAAMLAALLLCALGAPVEYEPTDSPAGDFSGEEQEVTPDLLSASPVWDLIIGVTAHHQKEFEDEFQQEVKYRFLNHYKLSSLPADCPSANFSKEACLQRLAEGLHTYMVLFKHVEKEYPSSSILLHARYHSGALIGLIKEKMRNPGQVTVPTSRQEQQLLQDMDNPSTFHRKMTAHNILRQLHNFLRNGKVAIRKREMPKQKRRKDDGIIPPIHPSYQMT
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
A0S0B0
A0RTP4
PDXT_CENSY
Pyridoxal 5'-phosphate synthase glutaminase subunit
Cenarchaeum
MSGPSIGVLSLQGDVRENIGMIHTAISRAGVGGSVEQVNDASAIKELDGLIIPGGESTVIGGLAGGELLDVIRTKVRGGMPAFGICAGLILLSKGATDRTVGRTGQPLLDLLDVRVERNAFGRQKESFETELSMTSCGIEEFRGVFIRAPVITEAGPGVQVIAEYDNKKVAVQQGSVLGVSFHPELTNDPSLHQYFLKMCA
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
A0RTP4
Q5DRC2
PCDG1_PANTR
Protocadherin gamma-A1
Pan
MKIQKKLTGCSRLMLLCLSLELLLEAGAGNIHYSVPEETDKGSFVGNIAKDLGLQPQELADRGVRIVSRGRMPLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFQMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFHLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAKAKVLIKVLDVNDNTPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGCTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRNLQLKVMARDSGDPPLSSNVSLSLFVLDQNDNPPEILYPALPTDDSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGSLTGMQSSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKKDFLSAPQSLLEDKKEPFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Q5DRC2
P59795
BPT_SPHEL
Aspartate/glutamate leucyltransferase
Sphingomonas
MTALSRFPRFFVTSPSPCPYLPGRQERKIFTELSGQQAGELNDALSRIGFRRSQSVAYRPSCAGCTACVSVRVVTEGFQPNATQRKLLKRYGDLEVTACKPWATGEQYELLKRYLDSRHPGGGMAAMDESDYADMVEQSPVSSYVIEYREPSVNGERGRLVGACITDQQGDGLSMIYSYFVTDDEARPGMGNFIIMDHILRARAAGLPYVYLGYWVKGSARMAYKTRYRPIEVLGPTGWALLEDEDMVGAMPSAVAAALA
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
P59795
A0A348B794
STS29_POSPM
Terpene cyclase 29
Postia
MSAVTQVVETAIGCVIPSCIEFGSSMRIATSLGSPSVTQSPCVNRDVEDIARTARESIRFFLAELSIECVPYTQDPALEAQVASATRCWPDRERLAPHIRTGIVIAATAYAHNSLATRTLIALYTAIGVALDEPDILESANAIGFHHSLCTETSERPSAILDEWRRILARMWDHFPRFGASCILTSTLQFLNMTMLENETKGKVLNRTAMPFVEYRRMTDGFPEVYTAFIWEKGRFPDVQVYMQAIPNAMRFINFGNDILSFYKEEAAGETGTYIHDRARLTGLSSVETLREVVEETVSAWRQVCEILGEGIARDAWNSFVRGYVTFHVHNPRYRLSELL
Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to a single major terpene scaffold whose chemical structure is still unknown.
A0A348B794
A1AAB6
EMTA_ECOK1
Peptidoglycan lytic endotransglycosylase
Escherichia
MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQIKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLDHVARNHPAPQAPRYIYKLEQALDAM
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
A1AAB6
Q46I99
GCST_PROMT
Glycine cleavage system T protein
Prochlorococcus
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKGKNIKSALQNLVPSDVFRIGPSEACYTVFLKENGGIQDDLIIYDQGVLDTNEESIVLVINAARKESDIEWLSSNLFKKEITISEFMPEGALIAIQGPESISTLEKILEEPLSNLPRFGHRTITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLRLEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLDKGIARKGYPVLYNSETVGIVTSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRRKKHPAIIVKRPFYRKGF
The glycine cleavage system catalyzes the degradation of glycine.
Q46I99
B1WU69
HISZ_CROS5
ATP phosphoribosyltransferase regulatory subunit
Crocosphaera subtropica
MIHQPPAGARDLLPLEVVQKAWINDTLQQVFGQWGYQRIVTSTIERLDTLKAGGAIEDETVIQLHNNSREQLGLRPELTASVARAAVTRMANTSYPQRLCYRANVFRNPPSGHHGRQLEFYQAGVELLFSGGTLADAEILLLVAECLQKLQIPSWYLILGDAGLTRSLLSPFPEALRQEVRHCLATLDYVKLDNLSYPNEELKHRASLLFNLRGKPEDVLSKVVDLTLDQTGKHCLNNLKSLIELVNHSTSYKLPLTLDLSLIQTFDYYTGIIFKAIGQTNHKLQNLGQGGRYDQLLGVYHPQKKSAPGIGFSLNVGALHRCLLSTDILPQKPLLIDYLVVAKTSESQIEALKYAQQLRKDDNSLRVTIDLENRNEEEIKKYAQENGIKTIVWIEKGKEAIIN
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
B1WU69
A8H745
GLMM_SHEPA
Phosphoglucosamine mutase
Shewanella
MKQRQFFGTDGIRGKVGAGKMTPELALKLGWAAGRVLSRSGTQKVIIGKDTRISGYLFESALEAGLSAAGLDVMLIGPMPTPAVAYLTRTFRAEAGIVISASHNPYYDNGIKFFANDGSKLDDEVELEIEAELEKPLTCVESHLLGKVNRIDDAAGRYIEYCKSHFPAEQTLSGLKIVVDCAHGATYHIAPSVFRELGAEVIAIGDKPNGLNINDKVGATSMGQICETVLAENADLGIALDGDGDRIMMVNRHGRVIDGDEILYILACDAQKRGVLRGGVVGTLMSNLGLDLALQALEIPFVRSKVGDRYVMELLKEHDWRIGGENSGHILNLDHGTTGDGIVAGILVLAAMQRQNASLEALTANITMLPQVLVNVRFEGDNDPLASEVVLAAQAEVEQKLGARGRVLLRKSGTEPLLRVMVEGDEQEAVTEYANYIADAVRNLV
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
A8H745
P41191
RL10_LIBAF
50S ribosomal protein L10
Liberibacter
MNRQEKSVEISELSKIFSSSGSVVVAHYKGISVAQIKDLRKKVREAGGGVKVAKNRLVKIAVSDTSLKGVSDLFVGQSLIVYSVDPIVAPKISVSFANDNKQFVVLGGILEKDILDQDSIKRIASLPNIDGIRSMIISAIQFNSTRLVNLLNAPQTKIVRAISAFVDKNQQS
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
P41191
B8D6X9
DNLJ_BUCAT
Polydeoxyribonucleotide synthase [NAD(+)]
Buchnera
MTSTKDKIEKLRKILLKYEYFYHTLNQSIISDAEYDYLFRQLYELELKNKELIPSDSPTQKVGSHILQKFKKIKHFSPMLSLENTFDVNGYLNFKKRIKKSIHNNEPLSFCCELKLDGVAISIIYEEGIFVRAATRGDGFEGENITSNARMIDSIPLKLKGIDIPKRLEIRGEVFMLKSNFIKLNKKYKLNQNKYFSNPRNAAAGSLRHIDPNITAERKLIFSCHGCDFFVKTNKELTTHYQRLMKCLSWGIPVNKEIVICSSDIEIIQFYKKIAQKRNFLDFDIDGIVIKVNSLELQKKIGSTTKSPRWAIAFKFSPKERITTLNDVKFQVGRTGVITPVAYFNPVYISGVMISKASLHNKNEIERLNLHFNDTITICRSGDVIPRLLNVIEIRRCDNAKKIIFPSFCPVCNTELLENIEEKLIRCHSGLTCDAQKKQALYHFFSKKSLYVVGLGPKIINELVEKGLVKNPIDFFYLKDIDLIQLKNVGKRKSIKIINSIKKCKKTTLKCFIYALGIPGVGEVVAGKIANYFIKLDKLMNSNILELNCISGVGKIISNNIFNYFSTISNREMVVKLIKQAGIFLNDQEIHKINSEKTYFFNKKIVLTGVFKSFSRIELKTILLSLGAKISNNISRKTDFLIYGNNFGSKFFRAKDLDVKIINQEELNSLIRIKEQ
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
B8D6X9
Q93QY7
MPRF_STAXY
Multiple peptide resistance factor
Staphylococcus
MTKELRSKLFTILKIAFALTLFTIVAITLYKELSHINLKDAIKSFSKINRFWLVALFLSGGASIIVLSIYDVILAKTLKLKIGLAKTIRIGYIVNALNAVVGFGGFIGASVRFLFYKNTTDDKKALFHTISIVLISMLTGLSLLSILVVIHVFDISHIFTPYPWVKWLMYVVALFLPIFVVFTIIKPVQKTHRLLGVYCTIVSGVEWFVAALVLYMSMAIVGVQIPFATFMGIFILAALSGLISFIPGGFGTFDLVVLLGLKALNVNEEAIVLGLSLYRFAYYLFPVLIALILSTFEFRSTAKRYWEDSRILVPVKDMTSLLGSYQKDIIARIPSFAIALLLLFTSLVFFLNNLTIIYDGLYDPNHYIYYIIVSIHTCACLLLLLNVIGVYKLSKRAILFSIISVLFIFIATAYTYASFILLSWLTVIFILLLVFYRRARVIKRPFRYSKLLLSVITGAIILYINHLVIKSTFYSLEIYHIEMLTSILRYYFWITILLVAIIVGVIVWWFEYRYRSSNSRDNIATCESIIDKYNGNYLSHLMYSGDKKFFINDNKDAFVMYRYHNNTYIILGDPIGNSESFYSLLEAFYKEAEYLGYDIIFYQVTDKYMSLYHSFGNQFFKLGEEAVINLTSFTTSGKKKRGLRATLNKLDDLGYSFEVLEPPFSQQMITDLKAISDDWLADKNEMHFSVGSFDEHYISQAPIGVLKDNEQSVIAFCTLMPTYYNGVISVDLIRWKQDIELPLMDSLYLNMLLWSKDNNYEHFNMGMATLSNVGQIPYSFYGERIAGRVFEHFNGLYRFQGLRRYKEKFNPKWEPRFLVYRKHQSLWVSMLKVMRVIRKNN
Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.
Q93QY7
B9KE78
GLMM_CAMLR
Phosphoglucosamine mutase
Campylobacter
MKLFGTDGVRGKAGEFLDSFLAMRLAMAAGIYFKDKALTNNILVGKDTRRSGYMIENAIVSGLTSIGYNVIEIGPMPTPAIAFLTEDMRCDAGIMISASHNPYYDNGIKFFDAHGNKLDEQAEAKIEEIYFNDKLIEEARTTKSQIGQAKRIDDVIGRYIVSIKNSFPKELTLKSLRVVLDVAHGASYKVAPTVFRELGADVIVINDKPNGLNINENCGALHPLNLALEVKKFRADVGFAFDGDADRLVVVDEKGEVAHGDSLLGVLALFLKKQGKLKSSVVSTIMSNGALKEFLTKYKIPHETCNVGDKYVLEKLKECGGNFGGEQSGHIIFSDYAKTGDGLVAALQFSALMLSEAKSASEILNQVKPYPQLLHNLKISEKKDLSKLAGLEELKKDLEKKGIASLFRYSGTENLIRLLLEAKDIKLLEKEMKVVESFFMKVLNA
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
B9KE78
Q02WZ5
PNP_LACLS
Polynucleotide phosphorylase
Lactococcus cremoris subsp. cremoris
MAKETFSIEFAGRTLTVETGQVAKQANGAVVVRYGDTTVLTAATMGKMATGDFFPLQVNYEEKMYAAGKFPGGFNKREARPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASGRVAAMFGSSLALAISDIPFDGPIAGVEVAYIDGKYVINPTVAEKESSSLELSVAGNINAINMVESGAKELSEEVMLGALLAGHNAVKELIEFQNEIVAKVGKEKAEVELLHVDEDLKAEVIAAYNSDLQKAVQVEEKLAREAATKAVKEAIISVYSAKYENDENLSIILRDLAEILEGMEHAEVRRLITEDKIRPDGRKIDEIRPLDAEIDFTPRSITHGTGLFTRGQTQALSTLTLAPMNEAQIIDGLNDEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKISGITPEILAEALAQAKTARFQILDVIEATIAQPREELAPSAPKIDTIMIPVDKIKVVIGKGGEQIDKIIAETGVKIDIDDEGLCSIFSSDQSAIDRAKEIIAELVREAKVGEVYEAKVVRIESFGAFVNLFGKQDAMVHISEMAWARTAKVEDVMKLGDVVKVKIMKIDDKGRVDASMRALVEKPEGYVEPERKPRERRDNKDRRNGNGFDRRNNDRNNHNNHNNNSGNHSFELRERKSHVDHEFPELSTKKPE
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q02WZ5
P73618
DEOC_SYNY3
Phosphodeoxyriboaldolase
unclassified Synechocystis
MEKSRQFDLAPYIDHAALDPATTREAIATCCAQALHHKFVAVCVYPSALSQAVELLRGKKVEICAVIGFPSGASTSGSKLYEAQEAAELGATELDVVINLGLLKDGNTEAVYNDIAPIVEATGLTVKAILEMGRLTESEKRLAAEICLDAGVQYLKTSTGWGKGATVADVRLLHQISQGRVGIKASGGIRTVEQAIALIEAGATRLGTSRGVELIQQQQQLWEQG
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
P73618
A0L4K6
SURE_MAGMM
Nucleoside 5'-monophosphate phosphohydrolase
Magnetococcus
MLILLTNDDGIASPGLQALKDALKERHDVVTLAPVKDMSGTAHAISRGEDIKLTRIAEYEVAINGTPTDCVMAGLRMVLRRPPDLLVSGINMGANVAEDLSYSATAGAAWEGALSGIPSMAVSLCGSAAPWHFESAIKVTHMVIRQWLENPLPPGTFLNVNVPNVPEYELKNPKPTRQGLRFNWPPPPVTAAGNPAFWDPTIPTPREEEFQLATDEEALRDGFTSVTALHCLFRHPHATERLKAWSLFR
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
A0L4K6
A7X5M5
UREF_STAA1
Urease accessory protein UreF
Staphylococcus
MIDHTHLRLFQFCDSQFPTGAFSHSFGLETYIQRNIIHDDHTFIAWLKMFLQEQLTYSDGLAMRLVYDALENDDTQKVLHIDKLMFVQNLPKETRVGAKQMGTRMVKLALELYNSPWIAWYHQQMQDKKAKLNPAICFTMLGHHLGVDIETIIDYYLYQNVSSLTQNAVRAIPLGQTAGQKIVTHMIPYIEETRKQIFELKEADFGMTAPGLELNQMAHENVNVRIFIS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
A7X5M5
B9KMG1
PTH_CERSK
Peptidyl-tRNA hydrolase
Cereibacter
MKLFVGLGNPGARYAGNRHNIGYMAVEAIAADHGFGPWRARFQGLTSEGRLGSEQVLLLKPETFMNLSGQSVGEAMRFYKLTPADVIVFHDELDLAPGKLRLKQGGGHAGHNGLRSIHAHVGEAYGRVRLGIGHPGHKDAVAAYVLNDFAKADQDWLADLLRGISDGAEALARGDGAKFQNAVALRMQPPKPEKPKPAAKAPEAQAPEAAPDARSALQKLADRFR
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
B9KMG1
P21992
FLAB3_TREPA
Flagellar filament 31 kDa core protein
Treponema
MIINHNMSAMFAQRQGGINGLAIAKNIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLNQAGQNIQNGISFIQATEGYLAETTEIVQRLRELAIQAANGIYSAEDRMQIQVEVSQLVDEVDRIASQAQFNGMNLLTGRFSRESALGPMQLHVGANMDQNEKIFINTMTASALGFFSDEGTDGSRSISIATVDGANKVIGTLDSALKEINKQRADLGAYQNRFETAYQGIAIAAENLQAAESRIRDADLAQQMVDYTKNQILEQSTMAMLAQANTQPQAVLRLMQ
Component of the core of the flagella.
P21992
Q3IYC6
GPH_CERS4
Phosphoglycolate phosphatase
Cereibacter
MPGVVFDLDGTLVHSAPDIHAAVNKALAEEGGAPFTLAEITGFIGNGVPVLIQRVLAARGEAPDAHRQAELQGRFMAHYEADPATLTSVYPGAEAAIRHLRAEGWRIGLCTNKPVGASRQILSLFGLLELFDAIIGGDSLPQRKPDPAPLRATAAALNEEVVLYVGDSEVDAATAEAAGLRFALFTEGYRHAPVHELPHHGLFSHHDELQDLLRRLLA
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Q3IYC6
B1IAM6
PYRF_STRPI
OMP decarboxylase
Streptococcus
MREHRPIIALDFPSFEVVKEFLALFPAEESLYLKVGMELYYAAGPEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNVHAAGGVEMMKAAREGLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEVQVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPVAAYHAIKDEWTQDWN
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
B1IAM6
P93472
DIM_PEA
Cell elongation protein diminuto
Pisum
MSDLEAPLRPKRKKIWVDYFVKFRWILVIFVVLPISFTLYFLTYLGDVRSEWKSFKTRQKEHDENVQKVVNRLKKRNPSKDGLVCTARKPWVAVGMRNVDYKRARHFEVDLSPFRNILDIDKERMIARVEPLVNMGQITRVTVPMNLALAVVAELDDLTVGGLINGYGIEGSSHKYGLFSDTVVAFEIILADGSLVKATKDNEYSDLFYAIPWSQGTLGLLVAAEVKLIPIKEYMKLTYKPVVGNLKDIAQAYSDSFAPRDGDQDNDEKVPDFVETMIYSPTRAVCMTGRYASKEEAKKKGNKINNVGWWYKTWFYQHAETALKKGLFVEYIPTREYYHRHTRCLYWEGKLILPFGDQFSFRFLFGWLMPPKVSLLKATQGEAIRNYYHEMHVIQDMLVPLYKVGDALEWSDREMEIYPIWLCPHKLFKLPIKTMIYPEAGFELQRRQGDTQNAQMFTDVGVYYAPGPVLRGEVFDGAEAVRKMESWMIENHCFQPQYAVSELNEKNFWRMFDAGLYEHCRRKYGAVGTFMSVYYKCKKGRKTEKEVREAEQAHLDTAYPEVDQPPD
Plays a critical role in the general process of plant cell elongation.
P93472
Q48NU4
CCA_PSE14
Phosphatase
Pseudomonas
MQIYKVGGAVRDRLLGQPVTDIDWVVVGASTEDMLVKGYRPVGTDFPVFLHPLTNEEYALARTERKSGVGYGGFVFHASPEVTLEQDLIRRDLTINAMAEDKDGNLTDPYNGQKDLEARILRHVSPAFAEDPLRVLRVARFAARYARYGFTIAPETLGLMRQLSESGELKALTAERSWKEISRALMEEQPQVFIQVLHDCGALKELMPEVEALFGVPQPAAHHPEIDTGVHVLSVLEQSAIHKHPLTVRWACLLHDLGKGLTPEAEWPRHIAHEHTGLRLIKAVNERFRVPRECQELALLVGQYHTHGHRALELKPSTLLELLQSFDVYRRPQRFEEFIAACEMDARGRHGFEQRSYPQADYLRGAAQAARTVSVQPLLEKGFKGKELGDALKNERLKALKIYKAEHVA
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
Q48NU4
A1RQ57
HUTU_SHESW
Imidazolonepropionate hydrolase
Shewanella
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLQRLEDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHFEGISKGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEAANQAGKPVSVGLLANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKASMAVQVQAMLNLQTAGAATLDYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWIGLKDRARLALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMQD
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
A1RQ57
A5UN95
PURA_METS3
IMP--aspartate ligase
Methanobrevibacter
MTCSILVGGAWGDEGKGKCITYLCGNDKPDIIARAGVGPNAGHSVEFNGEKYGLRLIPSGFVHTDAKLMIGAGVLVDKDVLFKEFEDLKKYNVKERTFVDPRCAIITKDHRERDKKSEHLAKKIGSTGSGCGPANSDRVLRTVKLANDVPELEDYLADVSLETNDVLDNGGDVFIEGSQGFALSLYYGTYPFVTSKDTTASTFAADVGVGPTKVDEVINVFKAYITRVGEGPFPTEISQEEAESKNIEEYGVVTGRRRRVGLFDMELAKESCRINGATQIALTCVDRLYPDCARTQSYDDLSAETKKFVEEIQSETGVPVTIISTGPDLKDTIDLRKELL
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
A5UN95
Q5VZK9
CARL1_HUMAN
Leucine-rich repeat-containing protein 16A
Homo
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSLRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQEKRAACAQKKLGNDAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEKEFIFV
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments . Plays a role in lamellipodial protrusion formations and cell migration .
Q5VZK9
A8FQ86
LEUD_SHESH
Isopropylmalate isomerase
Shewanella
MNPFTSHTGLAVMIDSANVDTDQIIPKQFLSKVTRDGFGVHLFHDWRYLDEAGDEPNPGFSLNLPRYKGASILISKENFGCGSSREHAPWALADFGLRAIIAPSFADIFYGNSINNGLLPVRLTDVEVQQLMDEVEASEGAEITVDLEELTVTSPSGAVFNFEIAGSARHNLLNGLDAIGLSLACADQIARYEAQLPTWKA
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
A8FQ86
Q80X66
BTBDA_MOUSE
Glucose metabolism-related protein 1
Mus
MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSSASRVAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIEREKDHSSSRPSSPRPQRASPNGSMSSAGNSSRNSSQSSSDGSCKTSGEMVFVYENAKEGARNVRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPSHPASGNNDLDPDAQNPML
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells.
Q80X66
P36421
SYYC_YEAST
Tyrosyl-tRNA synthetase
Saccharomyces
MSSAATVDPNEAFGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGCEVTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMDIFRLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEENLPSLGYKKRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGNVEENGLLSFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKIGVADAINELLEPIRQEFANNKEFQEASEKGYPVATPQKSKKAKKPKNKGTKYPGATKTNEIATKLEETKL
Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) . The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36 . Also involved in nuclear tRNA export . Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr .
P36421
A1WMN6
HISZ_VEREI
ATP phosphoribosyltransferase regulatory subunit
Verminephrobacter
MSAWVLPDHIADVLPSEARHIEELRRGLLDTARCYGYELVMPPLMEHLESLLTGTGEALDLQTFKLVDQLSGRSLGLRADTTPQVARIDAHLLNRKGVTRLCYCGPVLHTRPDRPHATREPLQFGAEIYGHSGLEADLEALQLARECLRVAGVRDTTIDLADMRIVRKLLAGVALSPQRLSRIHAALAAKDAGELAALTHCFAADSRAALLALLQLYGDEAVLAEAEKALQRIDGISPVLANLRWLASRLEGAQVTFDLADLRGYAYYSGARFAIYARGASDALVRGGRYDEVGAVFGRNRPAVGLSLDIKQVVGVVPPQTLKAAIRAPWGEAADVNAAIAELRAAGETVVCVLPGHESEVDEFHCDRELAQVSGRWVVQAV
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
A1WMN6
B1YNS0
BIOF_BURA4
8-amino-7-ketopelargonate synthase
Burkholderia cepacia complex
MTRTAPSSLRSLPAEGAAATDLLDTLQRGLAELDAQGLRRVRRTADTACDAHMRVDGRDIVGFASNDYLGLAAHPALVAAFAEGARRYGSGSGGSHLLGGHSRAHATLEDELAGFAGGFSDAPRALYFSTGYMANLAAMTALTGKHATIFSDALNHASLIDGIRLSRANVQVYPHADMAALAALLDASDAETKLIVSDTVFSMDGDIAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLIYVGTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRMTRWQPVDSHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVPAGTSRLRVSLSAAHSFDDLARLEAALIEASEGQTRRDAEQPPRSLRSLPPEGAAASLGAARRETAA
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
B1YNS0
Q8Y0V3
RSGA_RALSO
Small ribosomal subunit biogenesis GTPase RsgA
Ralstonia
MTRGKPGRAGHDRRHASTGEHGLVIAAHGRHYLVERKGGGLLQCFPRGKRSECAVGDRVIFEATAVDQGVVVRVEERRNLLHRSDQFKSKQLAANIDQVLIMLGTEPGFSEDLLGRALVAAESLGITPLILLNKIDLTARLETARARLALYRALGYAVVELSVHAAPEAAHAVLAAHVAGRSSILIGQSGMGKSSLLNLLIPGVDAQTREISEKLDSGKHTTTFTRLYHLPSGWGHGGTLIDSPGFQEFGLHHLTEGMLERAFPEFRPRLTECRFYNCRHLQEPGCGILGAMAEGKIDPRRHALYAQLLHESEQQKPW
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
Q8Y0V3
A0A067XMK8
PTAJ_PESFW
Pestheic acid biosynthesis cluster protein J
Pestalotiopsis
MAASTAAQVQLSEEALGLARIFENPKGSLEAASKLLQKNHDEFHVFWRDVGGHNHIPHSVLSILALGGGPAELQRAWDDGVAIQRPTPPLDEDVVKKLENPAEFRARIGSIPNYTNFLHFFRNQMDKKGWQAVVSEYAFSRTPLAETIFAQLFEGAYHPFIHIGFGIEFNLPSIIAEGLAQAATHDSAGIEGFFLEAERQAAQSKGPGKSLVQLLDEVRTTEKIKTAARLPDGPVRVRDGVIGRAGAEIAALASQFRVPADQLSRGAAESINISAYTAGAAQRAGKARKIDFFHMHNTTSSLFLTVFLNQPWISTEDKVRIVEWKGRLDLVWYAACSAPDLNVDHVIGYKPAQSAGWGWKELYEAINVAHDDGHLAKIVRALKNGEEVSRPFESGEGAEAFPIKGDSWLKLAQMSYDTTLDLPDDDKWIWGAGFLPLWNKVPSL
Baeyer-Villiger oxidase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes . The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA . As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain . The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone . Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC . Spontaneous decarboxylation of endocrocin occurs to generate emodin . An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion . PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin . PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step . Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin . Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin . PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulouchrin and chloroisosulouchrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
A0A067XMK8
B1KHG7
SYD_SHEWM
Aspartyl-tRNA synthetase
Shewanella
MRSQYCGDVNKSHVGQEVTLVGWVNRSRDLGGVVFLDLRDREGIVQVVYDPDLPEVFDVASTLRSEFCVQVTGLVRARPDSQVNQDMRTGGIEILGKGLTILNSSAPLPINMDKNQHNTEEQRLKYRYLDLRRPEMADRIVFRSKVTSAVRRFLDDSGFLDIETPILTKATPEGARDYLVPSRTYKGQFFALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFMSSEQVMAKTEEMVRGLFNDLLNVDLGEFPKMTFAEAMRRFGSDKPDLRNPLELIDIADIVKEVEFAVFNGPANDPEGRVAVLSIPGGAKLSRKQLDEYAKYVTIYGAKGLAWMKVNDLDQGMEGIQSPVLKFLSEDVVKALLDRTGAQTGDLILFGADKANIVAEAMGALRLKAGEDFDLLQGEWKPLWVVDFPMFERTSDGGLHAMHHPFTAPTGISPEQLEADPTAAISDAYDMVLNGCELGGGSVRIHNSEMQSAVFRILGIEEEEANEKFGFLLEALRYGTPPHAGLAFGLDRIIMLMTGASSIRDVMAFPKTTTAACPLTNAPGFANPAQLIELGIEVIENQESKEEQA
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
B1KHG7
Q99570
PI3R4_HUMAN
Phosphoinositide 3-kinase adaptor protein
Homo
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 .
Q99570
Q6G1D3
ACCD_BARQU
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Bartonella
MNWITNYVRPKINSILRRREIPDNLWIKDPTSGEMVFHKDLEVNQYVIPNSGYHMRISAKNRLMHFFDDGIYTPLENPKVVIDPLKFRDEKRYIDRLKDYRSKLGVDDNILSAQGTIEGLPIVATVQDFAFMGGSLGMASGEAIIKAFDTAIANKCPLVLFSASGGARMQEGTLSLMQMPRTTVAIEMMKEAKLPYIVVLTNPTTGGVTASYAMLGDIHIAEPGAMIGFAGPRVIQQTIRETLPEGFQSSEYLLEHGMIDMVVSRLEMKATIARLLRLIMKCPPAVNPSNPSPTDSQPPLSKAEAA
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Q6G1D3
P0CU17
RPN51_SCHPO
26S proteasome regulatory subunit rpn501
Schizosaccharomyces
MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQQAVAK
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.
P0CU17
P95399
AROE_NEIPO
Shikimate dehydrogenase (NADP(+))
Neisseria
MTALPRYAVFGNPVAHSKSPQIHQQFTLQEGVDIEYGRICADIDGFAQAVSTFFETGGCGANVTVPFKQEAFALADEHSDRALAAGAVNTLILLKNGKLRGDNTDGIGLVNDITQVKNIAIEGKTILLLGAGGAVRGVIPVLKEHRPARIVIANRTHAKAEELARLFGIEAVPMADLNGGFDIIINGTSGGLSGQLPAVNPEIFRSCRLAYDMVYGDAAQTFLNFAQSNGAAEVSDGLGMLVGQAAASYHIWRGFTPDIRPVIEYMKAL
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
P95399
C3KV13
UVRC_CLOB6
Excinuclease ABC subunit C
Clostridium
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEGAKAIRPCLNYQIGLCKAPCAQYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAGNLEFEKAAMLRDKINIIEKIGEKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPNIEDEVLLEQWLTLKKESKSTIKIPIKGEKKNILDLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDLILMDGGKGQINIALEVLNTFNINIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSISSMDKKSAESILEFFK
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
C3KV13
A1T0R0
HEM3_PSYIN
Pre-uroporphyrinogen synthase
Psychromonas
MTAQKIRIATRHSPLAMWQANFIKSELLKYHPNLIVELLPMKTKGDIILDTPLAKVGGKGLFVKELEVAILEGRADIAVHSIKDVPVDFPEGLGLTTICKREDPHDAFVSNHYKQLDELPEGAIVGTCSLRRQCQILALRPDIIIKNLRGNVNTRLRKLDEGEYDAIILAAAGLMRLEMQHRITSLIAPEVSLPAVGQGAVGIECRLDDEQTITLLKPLEDPETRIRITAERAMNLKLQGGCQVPIGSFAILENEQLFLRGLVGSVDGKQIIRKEITGHQNDAQQLGITLAEQLLACGAEEILAEVYKNQ
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A1T0R0
Q8UD80
HEM6_AGRFC
Oxygen-dependent coproporphyrinogen-III oxidase
Agrobacterium tumefaciens complex
MERPILPKGLPEDIEDKKAVAQAWFQHLRDTIVASFETLEDELTGPLSDQEPGRFVQKDWLRDNGEGGGGKMSMMEGRVFEKVGVHTSTVYGEFSPEFRKQIPGAEEDPRFWASGLSLIAHPVNPNVPAVHMNTRMVVTTSHWFGGGADLTPVLGRRRTQQDPDTQLFHRAFEITCNRHPIADYPRYKSWCDEYFFLKHRDEPRGTGGIFFDWLHPDEEKGGWDANFTFVQDVGRAFNLVYPKIVRANFNQNWTEEDRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVVRWP
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Q8UD80
Q6MCW1
SURE_PARUW
Nucleoside 5'-monophosphate phosphohydrolase
Candidatus Protochlamydia
MSSKPLILVTNDDGVHAKGIRHLWQSIQDLADLIIVAPQQEQSAVSLSITVRRPLHIEKVDWLNAQADVWSVNGTPADCVKLALNVVLPKRPQLIVSGINRGTNAGRNIFYSGTVAAIMEGVMQGIPGIAFSYGDYFNPSYHLIESFIPGIVNYALQNAMQEGTFLNVNFPKTEHGPIKGIRLTTQGKEYWAENPEKRQHPAEQNSYYWLGSKLAEYDEREDSDIFLLRKGFATVVPLHIGDLTNHSHLLKEKLAFETFVN
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Q6MCW1
A8H0Q6
RPIA_SHEPA
Phosphoriboisomerase A
Shewanella
MTQDEMKKAAGWAALQYVEENSIVGVGTGSTVNHFIDALATMKFDIEGAVSSSEASTEKMKALGIPVFDLNSVNELSVYVDGADEINSQMDMIKGGGAALTREKIVAAVADKFICIVDNTKQVDILGEFPLPIEVIPMARSYVARQIVKLGGDPVYREGCVTDNGNIIIDVYNMKIMKPKELEQQIDGIVGVVTNGLFAKRGADILLVGTPEGVKTVTF
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
A8H0Q6
A1S8D5
GRPE_SHEAM
HSP-70 cofactor
Shewanella
MSNESTNPQQEPLEQVQDTEVVTDEAALVDELTQANFRIEELEQALAAAEAKVEEQKDSVVRAAAEVDNIRRRAAMDVEKANKFALEKFANELLPVLDNMERALAGTNAEDEATKAMYEGVSLTMKTLVNAVEKFGVKVVDPMGQPFNPEQHQAIGMQPNPEVPANHVMVVLQKGYELNGRLLRPAMVMVSQGGGVDTQA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
A1S8D5
P0CY97
CH601_CUTAK
Heat shock protein 60 1
Cutibacterium
MAKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIELDDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIEAAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEIIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQSGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVISEEVGLSLDAVTLDLLGRARQVVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIIPGGGVALLQASKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAANDEYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGMGGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P0CY97
A9SR33
M2K1B_PHYPA
PpMKK1b
Physcomitrium
MSRRHRTGGLRVAVPKQENSIHRFLTANGVFHDDDIQLDHMGLRVVSSESTAYANPPDAQLSLADLEAVRVLGKGAGGSVQLVRHKWTNDIYALKGIQMNINETVRKQIVQELKINQLTLHQCPYIVKCYHSFYHNGIISIVLEYMDRGSLADIIKQTKQIPEPYLAVISNQVLKGLNYLHQVRHIIHRDIKPSNLLINQKGEVKISDFGVSAVLISSMAQRDTFVGTYTYMSPERLGGQSYAYDSDIWSLGLTILECALGYFPYRPPGQEEGWNNFFMLMELVINQPPVAAPPDKFSPEFCSFIAACIQKRPGDRLSTADLLKHPFLQKYSEEEYHLSNLR
The CERK1, MEKK1a/b, MKK1a/b/c and MPK4a/b proteins are involved in pathogen defense. The pathway induces rapid growth inhibition, cell wall depositions and accumulation of defense-related transcripts. This protein is required for full defense response to fungal pathogen chitin.
A9SR33
Q1GYZ3
RSMH_METFK
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Methylobacillus
MSAGISHVPAAQVSQHVTVLLEEAVEALSIKPDGVYVDGTFGRGGHSRKILEKLGAQGRLVALDRDLAAIQAAQGIQDARFKIVHSHFAAMAQVLASLNIQQVDGVLLDLGISSPQIDEGERGFSFRFDGPLDMRMDQSRGQTAAEFIATATEQELTRVIKEYGEERFAKQIARAIVAQRAGGMDISTTGQLAKIVAGAVPKVEPGQDPATRTFQALRIFINQELEELSLTLPQCLSLLAPQGRLAVISFHSLEDRIVKRFIRGEQDRDNLPAHFPVRASDLPQPRLVAIGRAVRPSEDEVRRNPRSRSAVLRVAERTAVL
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Q1GYZ3
P81244
CYC6_PROHO
Soluble cytochrome f
Prochlorothrix
AASGASIFSAKCAQCHLGGKNIINPTKTLSLADLQANGKDTVSAI
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
P81244
P24980
NU6M_BALPH
NADH dehydrogenase subunit 6
Balaenoptera
MMMYIVFILSIIFVISFVGVSSKPSPIYGGLGLIVGGGVGCGVILSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKVVLGAFVLGLVVEFLIVIYALKSGEVKIMFEFDGLGDWVVYDTGGSGVFSEEATGIAALYSYGVWLVIVTGWSLFISVVIIMEITRGS
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
P24980
A5UJB8
CPGS_METS3
Cyclic 2,3-diphosphoglycerate synthetase
Methanobrevibacter
MKSISKMLCLVDGEHYLPVTQESIDVLNNLEHIDIVAAVFIGGTEKLRDDSEESYSKVLGVPVQFAKNEDIPYDIIVEMINRYDVDTVMDLSDEPILDYPKRFKIACKTLAQGVSYQGPDFKFDPVTQYEIMEKPSIKIIGTGKRIGKTAVSGFVSRLIDKNGYEPCVIAMGRGGPQEPEIVHGEQLEITPEFLLEQSEKGVHAASDHWEDALMSRILTIGCRRCGGGMAGEVFLTNMKKGAKLANQVDSKFAIFEGSGAAIPPIKTNKNIVLIGANQPLNNIIDYFGPYRIGLGDLIILTMCEEPMCNEEKREYIEKFIKEINPKAKIISTVFRPKPLADISGKKVLFATTAPKSIEHELVDYLETNYNCEIVGTTPHLSNRPLLKKDIEKYMDEADIMLTELKAAAVDVATKDSIKAGLDVVYCDNIPVPINYKYPDLSKSVLEIVDEAIEDFNKD
Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
A5UJB8
P9WPG2
PGSA_MYCTO
CDP-diacylglycerol--glycerol-3-phosphate phosphatidyltransferase
Mycobacterium tuberculosis complex
MSRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARVVAWAIFATACITDRFDGLLARNYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVTVLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAIGLFVLPLSGPLHVAAVVVMAAAILLTVITGVDYVARALRDIGGIRQTAS
Probably catalyzes the synthesis of phosphatidylglycerophosphate by transferring a phosphatidyl group from CDP-diacylglycerol to glycerol 3-phosphate.
P9WPG2
A5FYS5
RLMH_ACICJ
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Acidiphilium
MTAPGARLRIIAIGRDSKGPEADLVARYAARLQPRPEVVALPDGTGSPAEIKRREADAILRRLAAEDLVIALDLGGKAPDSAAFAAMLASWRETSRPLAFVIGGAEGLERRIIERADAVLSLGNLTLPHLLARAVLAEQLYRAQCILAGHPYHRAGRP
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
A5FYS5
P73289
RL25_SYNY3
50S ribosomal protein L25
unclassified Synechocystis
MALSIECQQRPEKVNPRALRREGLIPATLYGHNGAESISLVVDHKTAITMLRSVTVKETPIEVKIPHLSWEGEAVVQEIQCHPWRRNLYHLAFFAGKK
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
P73289
B6J7Q0
MDH_COXB1
Malate dehydrogenase
Coxiella
MAKHVKVAVTGAAGQIGYALLFRLASGQAFGLDTTVDLHLLEIEPALPALKGVVMELEDCAFPLLRNMVVTSDPRVAFNDVNWALLVGAAPRKAGMERKDLLEKNGSIFAGQGKAINENAASDVRIFVVGNPCNTNCLIAMNNAPDIPKDRFYAMTRLDQNRAIGQLALKAGVDVPSVKNMIIWGNHSSTQYPDFYHATIDGKPATEVIRDKNWLLNDFIPVIQQRGAAVIKARGASSAASAANAALDSVWSLINTTPADDNYSVALCAQGQYGVDEGLIFSFPCRTENGVVSVIEEIEHNEFGQQKLKETLDELREERDAVEALGLI
Catalyzes the reversible oxidation of malate to oxaloacetate.
B6J7Q0
Q9TLS1
PREA_CYACA
Prenyl transferase
Cyanidium
MKVNSKTLQSVKEDLLNIEQTLNKLIKVNNPILSAAAKHLLIVESKKIRPAIVLLVAKAIDKNKKIKTSQQRLAEVTEIIHTATLLHDDVVDESIIRRGTKSVNKTFGNKIAVFAGDFLFAQSSWYLANINNLEVVKAISKVITDLAEGELQQNLTQFNTYYSIIKYLEKSFNKTASLIAASCKSCCLLSDFDQSLNSKFYNYGKNLGLAFQIIDDILDITSSSTALGKMTTSDLKLGNLTAPVLFALTKNSKLFKIIEREFCEKSDISEAINIIKETNAIEESFDLAYEHIEAAINSIKDLPTSSEKDSLIEIAYDLLNRYK
Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate.
Q9TLS1
C0ZG01
RPOZ_BREBN
Transcriptase subunit omega
Brevibacillus
MLYPSIDELTEKAESKYILVTVASKRARQLRENSEVQVVRPKSKKFVGLALEEFISDELVHEFLDGRK
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
C0ZG01
Q3B8R1
EMARD_RAT
Endoplasmic reticulum membrane-associated RNA degradation protein
Rattus
MEILTGDSITTCLSPLVHDLICNLGFELTEICDINSIVTQNGEVRWKAITDRVSYAELGHSLDYRQSVQRLGPVCEAIHLHISSLSRAQFETQYSPWYQWTTSPELFLEIYDALESSQSAAISLSVMKLASCLERALGDVFLLIGNECPFLLRDLLASAELAHVFGHAVMDVLKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCSALLLLTAGLGQLLKSYLHHTKVQLAHRPFVTLTNLEDVIVFPGVTDKVLSALETVMTKSSFLLKIMLPYWELAVSKFKSHRFADCTMLLLSQLEAGLRRVFATVNKCPDRLLTAESTILYTTFDEILAKHMSDGSINQLPCFLGEPAMDFLWDFLNYQEGPRIRDRLSHGEINIREFPKAAASQLLTFCLVLLLRFTEEDTLSELKEEAAIQLLVSLAERYRSRCHPAFQLQKQVLSCEKSLRMWPVLPLPEECCQEAGRSEGNSEACACNSLISKILCELCHYLPASACAINGLDGLPSEKWSQLLNELCNTRIPTLFCPKIVLEVLVVLRGISSQCQRVSDQVIASLQLRHRQWVEHTLRSRQRQNYVRMLSSVGLLCPVLSLILLLLALELVSVHAVHGKDAQERQQYLRFLKLILQYTENLVAYTSRQKNKWNEAVSLTRAVLLRIWTFSEKKQMLIHLTKNTNKVDTG
May play a role in neuronal migration during embryonic development.
Q3B8R1
Q15YB1
RPOB_PSEA6
Transcriptase subunit beta
Pseudoalteromonas
MVYSYSEKKRIRKDFGKRPQVLEIPYLLSIQLDSFKKFIDLDVDGQHGLEAAFRSVFPIKSYSGNAELQYVSYRLGEPVFDVKECQIRGVTFSAPLRVKLRLVLFDREAAPGTVKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKVLYNARVIPYRGSWLDFEFDPKDNLYVRIDRRRKLPATIMLRALEIPTEEILGMFFEKNQVRIDGNRFMSDIVPDRLRGETAQFDILDSDGNVLVEAGRRISARHTRALEKAGIVELEVPAEYLVGRVFACDYVDQETGELVVAANDLLTLENVLALKEAGYTTFETLYINELDHGAYISDTLRIDSSTNRLEALVEIYRMMRPGEPPTKDAAETLFTNLFFSEDRYDLSSVGRMKFNRRLGRETSIGAGTLDKDDIVDVMKQLITIRDGKDDVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDAVMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTDKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLASFARTNDFGFLETPYRKIVDGVVTDEIDYLSAIEEGQFSIAQANVVLDETGRLADDLIPCRHRGETTLKESSEITYMDVSPQQIVSIAASIIPFLEHDDANRALMGANMQRQAVPTLIADKPLVGTGMEKTVAVDSGVTVVAKRGGRVDYVDASRIVIKVNEEETVAGEAGIDIYNLTKYTRSNQNTCINQRPTCNVGEPIVAGDVLADGPSTDLGELALGQNMRIAFMPWNGYNFEDSILISERVAMEDRFTTIHIQELSCVARDTKLGPEEISSDIPNVGESALGKLDESGVVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPNSVRGTVIDVQVFTRDGVEKDKRALEIEGMQLRQVKKDLSDEFNILADGIFARAKNLLIKSGIEESRLESAQREKWFDLTLTDEDAQTELDQIAEQFVEIKADFDKKFEIKRRKITQGDDLQPGVLKIVKVYLAVKRQIQPGDKMAGRHGNKGVISTIKPVEDMPYDVNGTPVDIVLNPLGVPSRMNIGQILETHLGMAAHGIGVKIDRMLKEHEEMAKLRSFLKEVYGAGTTHQEVDLDNFSDDEITRLADNLRKGVPMATPVFDGATEAEIKHMLTLADLPESGQIALFDGRTGREFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLLKEIRSLGINIELEEQ
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q15YB1
P21842
CMA1_CANLF
Mast cell protease I
Canis
MHCLPLTLLLLLLCSRAEAEEIIGGTESKPHSRPYMAHLEILTLRNHLASCGGFLIRRNFVLTAAHCAGRFIMVTLGAHNIQKKEDTWQKLEVIKQFPHPKYDDLTLRHDIMLLKLKEKANLTLAVGTLPLSPQFNFVPPGRMCRVAGWGKRQVNGSGSDTLQEVKLRLMDPQACRHYMAFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGQNDAKPPAVFTRISHYRPWINKVLKQNKA
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
P21842
P61037
LNT1_TREDE
Apolipoprotein N-acyltransferase 1
Treponema
MKNKFIFFTLNLLLAVLGAVLFALSHPNYLNLNGFPFFAYIALIPFFLLLKRTKLKFSFLWGAFSGALSYFIFNFWIIFFHPLAIYIIIAKYCILYSVLFFVLKIIDSYFSRYSFIFQTIAWVAFEYLNTLGFLGYSYGIMGYTQWNFPILIRVSSIFGVWGISFLLVFFSACSASFLFEFYKEKDIKNVYQRYKLPMMIWVGTFFAFILYGAFTKIDLSEAQRARIALVQPNRDPWLGNLEVYRNNYEELKNLSEKALKNFPDIELVVWPETAFIPMIRWHYKYTSTYNPNSLLVRELLHFLDNQKVPFLIGNDDGVLDEKFSDNNFDNLEDKRLDYNAALLFIPKKNVSPPEPQTYRKMHLVPFTEHFPYQKLFPRFYEFLKENDTHFWEKGKEANLLEFNNFKIGTPICFEDTFGYISKAFSKKGANIIINLTNDAWANSAVSQYQHLSMAVFRAVENRLPVLRATSSGQTAFIDQNGNIQEMLPPFIKDILVADVTVLTEGHKTVYSYLGDFFGVLCTIVLILNLCFIIINKFIKRSEVK
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
P61037
A1WUM8
TIG_HALHL
PPIase
Halorhodospira
MQVSVETTEGLGRRMTVQVPAERVENEVERRLKDLSGRVKMDGFRPGKVPVKVVRKQYGAQVRSEVLSEVVQQTYSEALEQESLRPAGNPHIEPKRTGEGEDLEYEASFDVLPEIEVAGLDQIQVERPQVEITDADLDNVLERLRKQHADYQEVDRAAQDEDRVVIDFHGTIDGEAFTGNSAEDAPLILGAGQLPEAFEQGLQGAKAGQELTVEHKFPDELAEPSIAGKTAVFQVTVKRVEEPQLPELDDDFAARLGIQEGGVEALREAVRGNLERERHQAVRQRLKRQVLDQLADQNELELPKSLIDGEIQALRQQSGASAEGELPESERSAYEDVASRRVKLGLLVNELVRSQGIQLDRERMMTQLREMAANSGQDPSEALQQIAQDRQMMQSLEASVIEEQVVDWLLEQVQTEDKTLSFDELMNSEDGDQASA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
A1WUM8
A6WYK4
LEPA_BRUA4
Ribosomal back-translocase LepA
Brucella
MSTPLDHIRNFSIVAHIDHGKSTLADRLIQLTGGLDTREMKDQVLDSMDIERERGITIKAQTVRLSYKAKNGEDYVLNLIDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYQAIDNNHEIVVVLNKIDLPAAEPERVKQQIEEVIGIDAAQAVHISAKTGIGIEDVLEAIVTQLPAPKEGDRNAPLKAMLVDSWYDSYLGVIVLVRIIDGVLKKGQTIRMMGTGAKYPVERTGVFTPKMVQVDELGPGELGFITASIKEVADTRVGDTITEDRRPTNKMLSGFKPAQPVVFCGLFPVDAADFEDLRAAMGKLRLNDASFSFEMETSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLITTAPSVVYRLNMQDGSQKELHNPADMPDVVKINAIEEPWIRATIMTPDDYLGAIMKLCQERRGLQIDLTYVGPRAMITYDLPLNEVVFDFYDRLKSISKGYASFDYNLSDYREGDLVKMSILVNEEPVDALSMLVHRSAAEKRGRALCEKLKELIPQHMFKIPIQAAIGGRIVARETISALRKDVTAKCYGGDVTRKRKLLEKQKEGKKRMRQFGKVEIPQEAFIQALKMGDD
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
A6WYK4
P86327
LACC2_CERUI
Urishiol oxidase C2
Cerrena
AIGPVADLDIVNDQLTDASMIKWDCLPYDVRSPNPLGTTGFAGGNYRSVPADLHLTTLADPR
Lignin degradation and detoxification of lignin-derived products (Probable). Oxidation of a broad range of substrates including mono-, di- and polyphenols, aromatic amines and methoxy-substituted phenols accompanied by reduction of oxygen to water.
P86327
Q12MJ8
RSMF_SHEDO
rRNA (cytosine-C(5)-)-methyltransferase RsmF
Shewanella
MLQINPNFIKHIEQELPSHLSMDEFILACNRPLRQSIRVNTLRISSEDFIALMTPRGWSFSPVPWCSDGFWITLTHDEQLGNCLEHIQGLFYIQEASSMLPPTALFTNDDADERAPLRVLDMASAPGSKTTQMAALMNNNGLLIANEYSASRVKVLHANVLRMGVSNCALTHFDGRVFGEYQYEAFDAVLLDAPCGGEGTVRKDQNALKEWQLDDVIAIADTQKDLIEAAFLALKPGGALVYSTCTLSQLENQAICQHLLSRYPEAVAFESLATLFDGAAKACTEEGFLHVWPQIYDSEGFFVAKMRKTASVPRIKSQPKAQKNFPFSPAPEKQIAALQDYIQQSFALSLPPGAQVYLRDDEFWLFPAPFSDFIGTMRFQRIGIKLADVLKKGFKIKHEAVIALGAKLGTNANNNSNTNPNNNANTNPNNNSNTNPRCIPLNQAQAEQFLMGRDIDTASFDGKLDLTPKGEMMVSYHGAAIGVVKHLGHRLKNSLPRELVRDNLG
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
Q12MJ8
Q2QM59
PCF8_ORYSJ
Transcription factor PCF8
Oryza sativa
MEEVVVGGKERKRPRGALVGVGGGGASAATAAAWRTSRVARAAAGGKDRHSKVVTSRGLRDRRVRLSVPTAIAFYDIQDRLGVDQPSKAIEWLIRAAAAAIDALPSLDCSFALPAAASSPPPPAADDAEVSTSETSKSSVLSLANAPCDNGGGAFAELLHCSNTNGSKPLQQQQQATLAYYAAAQSAHMAAPMSFEVMAMPPHLAFSQEQQQHATVAAFDRGTLQSNASLWPPPPQPPPSQHPFLLQRFAAAPAEVAGLPFFLAGGVGGAAAAAPAATTNGGERRLQLWDFKEERKT
Transcription activator. Binds the promoter core sequence 5'-GGNCC-3'.
Q2QM59
Q9PWL7
HXBAA_DANRE
Homeobox protein Hox-B10a
Danio
MALHRHPFVHGAASWDGEQPSPVQLPHISACPFTSSGRKEDPFYFTLDPTGQARQPLDISAFSRIMTDMGSLNSADDHRPETSFYSGHKLLSLNTDTDPESPSLSSHSDSQHLHSLSLSAPCSETDNKHDMQYLAMESTKYPSQWSESRTNRSIITTLSISQRSKDDIEPNNLQTDFTRGDKTPREKTQDVTLENAANGWLSAKAGRKKRCPYSKHQILELEKEFLFNMYLTRERRLEISRSINLTDRQVKIWFQNRRMKLKKMTREHRTRDPGTSFTV
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Q9PWL7
Q8K947
RS12_BUCAP
30S ribosomal protein S12
Buchnera
MATVNQLVRKPRLRKIVKTNVPALEGSPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTAYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHIVRGSLDCAGVKERKKGRSKYGVKKAKV
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
Q8K947
O94260
G3BP_SCHPO
Putative G3BP-like protein
Schizosaccharomyces
MTAENATLLEPVLGKDEIGWMFVQEYYTYLNKEPNRLHCFYTKKSTLIHGDEGESISLCHGQQEIHNKILDLDFQNCKVLISNVDSLASSNGGIVIQVLGEMSNKGKLSRKFAQTFFLAEQPNGYFVLNDIFRFLREDVEEEEESPDAVEKEKKDVASEPYVNGVQSQEHLPSAKEEGHYQDPAATENNFATAALISNETDSLNQATLAVPEEPVIQVTEASVPSFVSQQENQLQDEALTSNSKNADAIGASDANVATAPKSWADLIARNHPDVKSQASVSSTASTTGQTVKGVNADQTQQPTAPYTQSNELLETSVFVKNIPPETSDVSLKSAMSIFGPVKAIEFARRKGTAYVDFVNHECVQLALNKKTLQINNATLNIEERRRLFSGKFNKSGDKKSNDNYNGMKRNFRKGNRGAFDGRSKEVTTSKKQNN
Probable scaffold protein that may be involved in mRNA transport.
O94260
Q5M821
PPM1H_RAT
Protein phosphatase 1H
Rattus
MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKVGTITSTPNRNSKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVVASRLLQHHITQQLQDIVEILKNSAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSAYNISGGCTALIVVCLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRVYDLSKYEHGADDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS
Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Q5M821
P29380
CYC_ARATH
Cytochrome c
Arabidopsis
MQVADISLQGDAKKGANLFKTRCAQCHTLKAGEGNKIGPELHGLFGRKTGSVAGYSYTDANKQKGIEWKDDTLFEYLENPKKYIPGTKMAFGGLKKPKDRNDLITFLEEETK
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
P29380