accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A2C4V4
PSAB_PROM1
PsaB
Prochlorococcus
MATKFPSFSQGLAQDPTTRRIWYGIATAHDFESHDGMTEEQLYQKLFSTHFGHLAIIGLWVAGNLFHIAWQGNFEQWVLDPLHTRPIAHAIWDPHFGQGLTDALTQAGATSPVNIAYSGLYHWWYTIGMRTNEQLFQGAIFINILVCWLLFAGWLHLQPKYRPSLAWFKNAESQLNHHLAVLFGFSSIAWTGHLIHVAIPESRGIHVGWENWLTVMPHPEGLTPFFSGNWGAYAQNPDSIDAVFGTSQGAGTAIFTFLGGLHPQSESLWLTDIAHHHLAIGVVFIIAGHMYRTNFGIGHSLKEIIEAHNTSHPKDPHRGYFGIKHNGLFETVNNSLHFQLGLALASLGVACSLVAQHMGALPSYAFIARDYTTQSALYTHHQYIAMFLMVGAFSHGAIFFVRDYDPELNKDNVLARILSTKEALISHLSWVTMLLGFHTLGIYVHNDVVVAFGTPEKQILIEPVFAQFAQAASGKMMYGFNALLANASSSASIAANSMPGNHYWMDMINRPDALTNFLPIGPADFLVHHAIALGLHTTALILIKGALDARGTKLIPDKKDLGFAFPCDGPGRGGTCDSSSWDATYLAMFWALNTIAWITFYWHWKHLAIWMGNTAQFNESGTYLMGWFRDYLWLNSSQLINGYNPFGVNALSPWAWMFLFGHLIWATGFMFLISWRGYWQELIETLVWAHQRTPIANLVGWRDKPVALSIVQARLVGLTHFTVGNFVTFGAFVIASTSGKFG
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
A2C4V4
P09820
FIXC_RHIME
Protein FixC
Sinorhizobium
MTKEKFDAIVVGAGMSGNAAAYAMASRGLKVLQLERGEYPGSKNVQGAIMYANMLEAIIPDFRNDAPLERHLVEQRFWIMDDTSHTGMHYRSDDFNEVTPNRYTIIRAQFDKWLSRKVCEAGGTVLCETTATGLEWDSAGKAIGVRTDRAGDVVLADVVVLAEGVNGLLGTRAGLREMPKSKNVALAVKELHFLPEEVIAERFGLTGDEGCVIEAGGTISRGMAGLGFLYTNKESISLGIGCLISNFAETMERPYALLDAFKRHPSIQPLIAGSEVKEYAAHLIPEGGFNAIPRLCGNGWVVVGDAAQLNNAVHREGSNLAMASGRMAGEAISIIKSRGGVMDKASLSLYKTMLDKSFVVEDLSKQKDMPSLLHTNSPNFFTTYPQLISHAAQNFVRVDGTPKIEREIATTAAFLRARSRWGLVSDAVRLASAWR
Could be required for the formation of a functional nitrogenase Fe protein. Probably accepts electrons from FixA/FixB and reduces a quinone.
P09820
A3QEP9
CMOA_SHELP
Carboxy-S-adenosyl-L-methionine synthase
Shewanella
MNSTQDTIYAQACEHISDFQFDDRVAGVFSDMIRRSVPGYGQIINTLGDFADKCVTPNSKIYDLGCSLGAATLSVRRRIEGRGCEIIAVDNSESMIERCKQNLSAYVSETPVDLICADIRDIEIQDASMVILNFTMQFLAPEDRQTLIAKIYQGLKPGGILVLSEKLVFEDEPVQHLLDELHLDFKRANGYSELEISQKRSSLEHVMKPDTLPQHQQRLKAQGFSHFSVWFQCFNFASMVAIK
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
A3QEP9
Q5E6U4
YBEY_ALIF1
Endoribonuclease YbeY
Aliivibrio
MSIELDLQIACENENGLPSEKELMTWLNAVIPQFQPQAELTIRIVDEKESHELNHEYRGKDKPTNVLSFPFEAPPGLELNLLGDLIICRQVVEEEAIEQNKPLLAHWAHMVVHGSLHLLGYDHIEDDEAEEMESLETELMQGMGFEDPYIAEK
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q5E6U4
O75509
TNR21_HUMAN
Death receptor 6
Homo
MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
O75509
P80961
AFP4_MYOOC
Antifreeze protein LS-12
Myoxocephalus
MKFSLVATIVLLALAQGSFAQGAADLESLGQYFEEMKTKLIQDMTEIIRSQDLANQAQAFVEDKKTQLQPLVAQIQEQMKTVATNVEEQIRPLTANVQAHLQPQIDNFQKQMEAIIKKLTDQTMAIEN
Antifreeze proteins lower the blood freezing point.
P80961
A5D4K4
THIE_PELTS
Thiamine-phosphate pyrophosphorylase
Pelotomaculum
MVRRRGLSGLLEADIYGITAWEYSLGRSNIEVVAQMIEAGIKVIQYREKERPARQKYEECLKIREMTREAGVTFIVNDHVDLALLVDADGVHLGQDDLPADRVRELVGDKMIIGLSTHSPAQARAAEKMGVDYIGVGPIFATKTKKDVCDPVGLEYLEFVVKNISLPFVAIGGIKEHNIAEVSSRGAKCIALVTEIVGAEDIKAKVRALRAIISRKED
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
A5D4K4
P32552
RS7_HALMA
HmaS7
Haloarcula
MSAEDTPEADADAAEESEPETARAKLFGEWDITDIEYSDPSTERYITVTPIAHTMGRHADKQFKKSEISIVERLINRLMQTDENTGKKQLATSIVTEAFELVHERTDENPIQVLVSAVENSAPREETVRLKYGGISVPKAVDVAPQRRVDQALKFLAEGVYGGSFKTTTTAAEALAQQLIGAANDDVQTYAVNQKEEKERVAAAAR
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
P32552
A7NR50
RS14Z_ROSCS
30S ribosomal protein S14 type Z
Roseiflexus
MARKALMVKAQRPQKYTVRAYNRCKICGRSRAYMRKFGMCRICFREHALRGLIPGVTKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
A7NR50
Q3AP13
ATPB_CHLCH
F-ATPase subunit beta
Chlorobium
MQEGKISQIIGPVVDVDFPEGRLPSILDALTVKREDGSKLVLETQQHLGEERVRTVAMESTDGLVRGMGVVNTGAAIQVPVGAEVLGRMLNVVGDPIDGRGPVNSKKTYSIHRSAPKFEDISTKAEMFETGIKVIDLLEPYSRGGKTGLFGGAGVGKTVLIMELINNIAKQQSGFSVFAGVGERTREGNDLWHEMMESGVIDKTALVFGQMNEPPGARQRVALTGLSIAEYFRDEENRDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQDRIVSTKKGSVTSVQAIYVPADDLTDPAPATAFTHLDATTVLSRSIAELGIYPAVDPLDSTSRILDPNVVGDDHYNTAQAVKQLLQRYKDLQDIIAILGMDELSDEDKLVVSRARKVQRFLSQPFFVAEAFTGLAGKYVKLEDTIKGFKEIIAGKHDKLPENAFYLVGTIEEAIEKAKTL
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q3AP13
A6UPJ0
RPIA_METVS
Phosphoriboisomerase A
Methanococcus
MAKPKKSDEEVSIDSDSLKIKVAKEAAKLIKDEMVVGLGSGSTANLFIQELGKRVIEEELYIYGVPTSFDSRMMANQSGIPLISLDQCGEIDIAIDGADEIDKKTFSLIKGGGGCHTMEKIVDYYAKEFVVLADESKMVDSLGENTPVPLEVIPFSYSTVLSKLLKINAAPAIRSGSGKMGPVITDNGNMIIDVFINIEDAEETETMLNSIPGVLENGIFTKCDKVLIGTSKKVEVLKK
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
A6UPJ0
B5RCZ3
RODZ_SALG2
Cytoskeleton protein RodZ
Salmonella
MNTEATHDQNEAQTTGVRLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPSDLASTFLRGYIRSYARLVHVPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMSFTWLVLFVVVGLTGAWWWQNHKAHQEEITTMADQSTAGLNADKDSGQSVPLDTGAVTSQDTTPAQTAPAPATPVDSTAATQTPAPTAAATQNTVVAPSQANVDTAATSAAPAATETPSALPTSQAGVAAPAADPNALVMNFTADCWLEVTDATGKRLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEPTPAQ
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
B5RCZ3
P0A4H3
BVGA_BORBR
Virulence factors putative positive transcription regulator BvgA
Bordetella
MYNKVLIIDDHPVLRFAVRVLMEKEGFEVIGETDNGIDGLKIAREKIPNLVVLDIGIPKLDGLEVIARLQSLGLPLRVLVLTGQPPSLFARRCLNSGAAGFVCKHENLHEVINAAKAVMAGYTYFPSTTLSEMRMGDNAKSDSTLISVLSNRELTVLQLLAQGMSNKDIADSMFLSNKTVSTYKTRLLQKLNATSLVELIDLAKRNNLA
Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.
P0A4H3
Q04VC9
GRPE_LEPBJ
HSP-70 cofactor
Leptospira
MAETSNSENKTSEEAKASEKNSRSITLEETKLENMNSEESTQTTESTQAQAAEAADSELSLQSELDAAKKEVESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQSPSEELKPFVEGVAMILKEFYAVLEKSNVIRFDPKGESFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKENEDKFTLRPARVRIGKPKS
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Q04VC9
Q9PD94
HSLU_XYLFA
Unfoldase HslU
Xylella
MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDVLLPRRSVGIGFDVDADVIRQEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLTIKAARPLLIEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLEMLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
Q9PD94
O80507
CSK2E_ARATH
Putative casein kinase II subunit beta-4
Arabidopsis
MYKDRSGGGIMGGGGSSRSEILGGAIDRKRINDALDKHLKKSSPSTSRVFTSKDKDSVPSTSTAKSQLHSRSPDVESDTDSEGSDVSGSEGDDTSWISWFCNLRGNEFFCEVDEDYIQDDFNLCGLSGQVPYYDYALDLILDVESSNGDMFTEEQHEMVESAAEMLYGLIHVRYILTTKGMAAMMEKYKNYDFGRCPRVFCCGQSCLPVGQSDIPRSSTVKIYCPKCEDIYYPRSKYQGNIDGAYFGTTFPHLFLMAYGNMKPQKPAQNYVPKIFGFKVHNKQ
Plays a complex role in regulating the basal catalytic activity of the alpha subunit. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis . CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation .
O80507
Q57IX6
HSLO_SALCH
Heat shock protein 33 homolog
Salmonella
MPQHDQLHRYLFENFAVRGELVTVSETLQQILDNHTYPQPVKTVLAELLVATSLLTATLKFAGDITVQLQGDGPLSLAVINGNNQQQMRGVARVQGDIPDNADLKTLVGNGYLVITITPEEGERYQGVVGLEGDTLAACLEDYFLRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNAQAEDFDHLAMLTETIKSEELLTLPANDVLWRLYHEEEVTLYDPQNVEFKCTCSRERCAGALKTLPDEEVDSILAEEGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Q57IX6
A8FKW6
SYP_CAMJ8
Prolyl-tRNA synthetase
Campylobacter
MRFTKFYAPSLKEAPKDASLPSHIFLTRAGFIEQIGSGLYNFLPLGKRVLDKIKNIVKEEMDKAGAQEVNLSFITPASLWQESGRYNVFGKELLRFKDRKENEFVLGPTHEEAMLSLVKNKITSYKQLPLHLYQIGLKFRDEARPRFGLLRCREFLMKDGYSFHANEEDLGCEFELMYKTYSQILQRMGLDFRAVEADSGAIGGSGSKEFMVLAKNGEDDILICENCDYAANVEAAKRAKKTCQDERPEANYASKFHTPNIKTIDSLAQFFKINAFYTIKAVVKKAIYENESKLVVFFIRGSDDLQEIKAQNACSALELVDASEEELEKAGLVAGFIGFVGLKDIDFYIDFELENEKQMIMGANEKDYHLIGIDVVNLNKDRFKDLIEVKEGDCCAKCGAKLKQSKGIEVGHIFKLGQKYSKAMNANFLDENGKSQPFYMGCYGIGVSRLLAVAIEASHDEKGCIWNKTLAPFVLEIIVSNLKDEKALEFANKLYEDLTNLGLEVLLDDRNERFGVKMNDFELMGFPYALVIGKGLENNEIELIQREGLVKELIKTDELMEILKKKVL
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
A8FKW6
Q3ZJ61
PSAI_TUPAK
Photosystem I reaction center subunit VIII
Tupiella
MAASFLPSILVPLVGLIFPAIAMTSLFIYIEKQEVN
May help in the organization of the PsaL subunit.
Q3ZJ61
Q7UZY1
LIPA1_PROMP
Sulfur insertion protein LipA 1
Prochlorococcus
MTNISKNAVTKPDWLRVKAPQVERIGNTANLLSDLKLNTVCQEASCPNIGECFASGTATFLIMGPGCTRACPYCDIDFDRSKRDLDPTEPDRLAEAVFRLKLKHVVITSVNRDDLDDGGASQFYKCVSEVRKKSPETTIELLIPDLCGNWSALEKILDSRPNVLNHNIETVSALYRKVRPQGNYQRTLELLKRTREYFPSVYTKSGFMLGLGEKDDEVLTLLMDLRKNDVDIVTIGQYLSPGPKHLQVQRFVTPSKFNYFKLFGENELGFMQVVSSPLTRSSYHAEEIQKLMKKFPR
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Q7UZY1
Q0JB89
MYB58_ORYSJ
Probable transcription factor MYB58
Oryza sativa
MARAPGGVRRRSGRRGAGGGGAGGGGEALRKGPWMAEEDEVLLEHVRTHGPMDWSSIRSKGLLPRTGKSCRLRWVNKLRPNLKSGCKFTAEEERVVIELQAQFGNKWARIATYLQGRTDNDVKNFWSTRQKRLARLLRGPLPAARPNKHNSGKGKAPSSSSLDSQTATFHQSSASLDQASLEGNSLGWQCREAAPFMGYDQACSGFFAFEGPLPLQLLPPADGEASSSNAAQSAPPPLLFDQPPYPLINFPGWPERYVDVGHGFVDAGAMDGLAYQELLPMVQSVPMIMPFFGMECAHDAVKHGAFDDLPPNMFDDAVDQPPPPPPPPPPPSPSPSPSRDDVL
Probable transcription factor.
Q0JB89
A7FVM3
PDXA2_CLOB1
Putative D-threonate 4-phosphate dehydrogenase
Clostridium
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVEAIILAAKYSPKFKK
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
A7FVM3
P39084
RLXN_LITCT
Ranalexin
Lithobates
MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDNPDERDVEVEKRFLGGLIKIVPAMICAVTKKC
Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.
P39084
A9M881
PROB_BRUC2
Gamma-glutamyl kinase
Brucella
MLKKLKDYRRIVVKIGSALLVDRATGLKREWLESLGQDIAALQHAGVEVLVVSSGAIALGRTVLGLPKKALKLEESQAAAAAGQIALAKAYADVLGGHGIKSGQILVTLSDTEERRRYLNARATIETLLKLKAVPIINENDTVATTEIRYGDNDRLAARVATMMGADLLILLSDIDGLYTAPPHKNPDAQFLPFVETITPQIEAMAGAAASELSRGGMKTKLDAGKIANAAGTAMIITSGTRFGPLSAIDRGERATLFEAAHAPVNAWKTWISGNLEPAGRLTVDAGAVKALKSGKSLLPAGVKEVDGDFERGDTVAVMNEDGREIARGLIAYDAADARKVAGHKSDEISAILGYDARAAMIHRNDLVVRAASDAKAA
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
A9M881
Q4FNA8
RECR_PELUB
Recombination protein RecR
Candidatus Pelagibacter
MQNINEIEELIKLISKLPGLGPKSAKRIVLKLINNRDELVKPMANTLAQVYKNVIRCQSCGTLKSNSLGCNNCENSKEKYNKICVVEDIADQWSIENSNIYKGYFHILGGTISSAGQRKEDLLINSLVERVSRENIEEVILATSATVEGQTTAYYIEDSLKKTSTKVTKLAQGLPVGGEIESLDDGTLYSAFKNRTGIKTNSD
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Q4FNA8
P0AFF4
NUPG_ECOLI
Nucleoside-transport system protein NupG
Escherichia
MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGASIGAVYSSLGIAAVFMPALLGIVADKWLSAKWVYAICHTIGAITLFMAAQVTTPEAMFLVILINSFAYMPTLGLINTISYYRLQNAGMDIVTDFPPIRIWGTIGFIMAMWVVSLSGFELSHMQLYIGAALSAILVLFTLTLPHIPVAKQQANQSWTTLLGLDAFALFKNKRMAIFFIFSMLLGAELQITNMFGNTFLHSFDKDPMFASSFIVQHASIIMSISQISETLFILTIPFFLSRYGIKNVMMISIVAWILRFALFAYGDPTPFGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVSPAIRASAQGMFLMMTNGFGCILGGIVSGKVVEMYTQNGITDWQTVWLIFAGYSVVLAFAFMAMFKYKHVRVPTGTQTVSH
Broad-specificity transporter of purine and pyrimidine nucleosides . Can transport adenosine, uridine, thymidine, cytidine, deoxycytidine, guanosine and inosine . Can also transport xanthosine, but with a very low affinity . Transport is driven by a proton motive force .
P0AFF4
Q931U2
PT1_STAAM
Phosphotransferase system, enzyme I
Staphylococcus
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNSAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDIIIVDGLNGDVIVNPTEDELIAYQDKRECYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMDGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Q931U2
A8ID68
TRMFO_AZOC5
Folate-dependent tRNA(M-5-U54)-methyltransferase
Azorhizobium
MSQTSLQPVHVVGGGLAGSEAAFQLAERGVPVVLHEMRPVRGTEAHHTDGLAELVCSNSFRSDDAQTNAVGVLHAEMRRAGSLILRCADANQVPAGGALAVDRDGFSQAVTAALAEHPLVEIRREEVTAIPPEEWDNVIIATGPLTSPALAQAVLELTGESALAFFDAIAPIVHLDSIDLSKAWFQSRYDKVGPGGTGADYINCPLDKEQYEAFVDALLASEKVPLRDFEAKTPYFDGCLPIEVMAERGRETLRFGPLKPVGLTNPHNPDVKPHAVIQLRQDNKLGTLYNLVGFQTKMRHGEQVRVFRTIPGLENAEFARLGGLHRNTYLNSPRLLDGTLRLKAAPRLRFAGQITGCEGYVESAAVGLMAGRFAAAERRGEALVPPPATTAHGALLAHITGGHIETVDAGPRSFQPMNVNFGLFPQLDVSPKGADGKRLRGSEKTLAKKRLLAERALSDMSAWLDTPAAAA
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
A8ID68
Q5WVN3
LPXK_LEGPL
Lipid A 4'-kinase
Legionella
MSFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGVGKTPLVIEIAKKIQQKGLKVGIVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINCPVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIEIVVIDGMRKLGNGFCLPAGPLREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGNPQRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLPVEAKLNDSFWEAFWSHQQLQGYY
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Q5WVN3
Q72DU3
TRMD_DESVH
tRNA [GM37] methyltransferase
Desulfovibrio
MRCTILTLFPEFFDSPLDAGLMGKARESGLIDVALVNPRAYTTDRHSTVDDRPYGGGPGMVMRVEPWEKALQGIEEPGRILMMAPKGRPFTQAMARELAQEESLTILCGRYEGFDARLEEIYPIEAVSMGDFVLNGGETAALAVLEAVSRLVPGFMGKEESGTEESFSAGLLEYPHYTRPEDYAGHVVPEVLRSGDHGRIAAWRKECSLRLTLSQRPDILPEAQLDEADMDFLRGLSRNRPGRNLYCALVHYPVVLKEKNSGATSLTNLDIHDIGRSSCTYGLGGFYVTTPLEDQRRLLDTLLRHWTLGPGSRSNPDRAEALGRIKGVDDVRAAIEDIARRTGQVPYVVGTSAKGAGNATPASVRAMLEERPVLLVFGTGHGLAPEVLEGCDAILRPLRWMDGYNHLSVRAAAAIIMDRLLGDCY
Specifically methylates guanosine-37 in various tRNAs.
Q72DU3
Q4G360
RK22_EMIHU
50S ribosomal protein L22, chloroplastic
Emiliania
MSKTLLQENETMAVARYVRMGPNKVRRVLRQITGKSYSEALLLLEFLPYKSCDPIIKVLRSAVANAKNNLGYDTTKLVIKKAFADQGPVMKRFRPRAQGRAYRILKPTSHITIVVGS
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q4G360
P17707
DCAM_HUMAN
S-adenosylmethionine decarboxylase beta chain
Homo
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
P17707
C0HJV4
CTX23_LACTA
Cytoinsectotoxin-2c
Lachesana
SWDSIWKSAKNKMDKIMRQKVAKWMAKKEGKSVEEVQAKVDAMSKKDIRMHVISHYGKKAFEQLSKSLEE
Insecticidal and antimicrobial peptide. Has insecticidal activity against larvae of flesh fly S.carnaria. Has antibacterial activity against Gram-positive bacterium B.subtilis B-501 (MIC=1.25 uM) and Gram-negative bacterium E.coli DH5alpha (MIC=2.5 uM).
C0HJV4
A3CPK9
UPP_STRSV
UPRTase
Streptococcus
MGKLEVIAHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTVQKQIAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLKPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASHITFVCLVSAPEGVKALQEAHPDVDIFTAALDDHLNDHGYIVPGLGDAGDRLFGTK
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
A3CPK9
A8MHH1
PYRH_ALKOO
Uridine monophosphate kinase
Alkaliphilus
MLEPQYKRVLLKLSGEALAGEKGFGLDPNVVTNIATQVKDIVNMGVEVAIVVGGGNYWRGRTGEGMDRTTADYMGMLATVINALALQDSLENLDVLTRVQSAIEMRQIAEPYIRRRAVRHLEKNRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILLAKNVDGVYSADPSIDKTATKFNELTYIDVLKMGLKVMDSTAISLCMDNSIPIKVFGLEDPENIKKVIYGDKIGTYIYS
Catalyzes the reversible phosphorylation of UMP to UDP.
A8MHH1
P53396
ACLY_HUMAN
Citrate cleavage enzyme
Homo
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
P53396
Q46GC9
RS11_METBF
30S ribosomal protein S11
Methanosarcina
MADMKWAVAHIKSSFNNTIITVTDITGAETIAKSSGGMVVKAARDESSPYTAMQMAGQLADQLRDKGIHGIHIRVRAPGGNKQRSPGPGAQAAIRAFARAGIRIGRIEDVTPVPHDGTRPKGGRRV
Located on the platform of the 30S subunit.
Q46GC9
Q9PET2
GLYA_XYLFA
Serine hydroxymethyltransferase
Xylella
MFPRDARLDMYDPELAKAIAAEVMRQEDHVELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCECVDIAEQLAIERAKQLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNGQGLIDYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAACVYPNPLPHAHVVTSTTHKTLRGPRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAETLMLRGYKIVSGGTENHLMLVDMIGRDVSGKDAEGALGQAHITVNKNAVPDDPRSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAPADATVIAAVREKVAAQCRKYPVYR
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Q9PET2
Q7MUX4
PYRE_PORGI
Orotate phosphoribosyltransferase
Porphyromonas
MKTLGKLIASKLIEVKAIKLQPNNPFTWASGWKAPIYCDNRKTLSYPQIRSLIKLELARVISETFGDVEAIAGVATGAIAQGALVADLLGLPFVYVRSSPKDHGLENLVEGELKPNSKVVVIEDLISTGGSSLKAAEAIRNFGCEVLGMVAVYTHGFPMAEQNFEKAEVKLVTLTDYDQVIEEALRTGYISAENVELLREWRKSPETWGI
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Q7MUX4
Q5F8I1
LIPB_NEIG1
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Neisseria
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIPVVQIDRGGQITYHGPGQLVVYTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPKRPGIYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTQINPCGYAGMEMTQIADFVQPCPAPDEVASKLTAHLETQLTPKADNNE
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Q5F8I1
A9MB89
GLPK_BRUC2
Glycerokinase
Brucella
MSGYILAIDQGTTSTRSMLFDRNMRVVGLGQQEFTQHFPSSGWVEHDAEEIWKSVQSTIRIALAQAGISAADVAAIGITNQRETTVVWDRISGKPVHRAIVWQDRRTAQFCDELKRRNLEPLFTEKTGLLLDPYFSGTKLAWLLNHVPGLRERAQKGQVCFGTIDSWLIYKLTGGKAHVTDATNASRTLIYHIGENRWDDELLDILGIPAAMLPEVKDCAADFGMTDPALFGVSIPILGVAGDQQAAVIGNACFEPGMMKSTYGTGCFALLNTGTDRVTSSNRLLTTIAYRLDGVTTYALEGSIFIAGAAVQWLRDEMGFISVASEVSALAEKADPNQRIYLVPAFTGLGAPYWDAEARGAIFGLTRGTGRAEFARAALESVAYQTFDLLEAMQGDWKGATNHTVLRVDGGMVASDWTMQRLADILNAPVDRPVFLETTVLGAAWLAASRAGIWPDRKGFSERWQRDCRFEPAMPEKERESAIAGWRDSVSRCLTRPQ
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
A9MB89
A6W2I4
PANC_MARMS
Pantoate-activating enzyme
Marinomonas
MKTFHTVAELRTALKIERLKDKKIVFVPTMGNLHDGHMSLIRKAKEEGDIIVSSIFVNPMQFSDQSDLERYPKTLEEDKRVLEANGCNYLFAPDALEMYPDGKRSQTQIEVVGISDILCGASRPGHFVGVSTVVTKLFNIVQPDTAIFGNKDFQQLKVIQDMVRDLSSNVRIIGVDTARNEDGLAMSSRNGYLTEEERRIAPTIYQTLLWAKEALLENRASHEDICEQAQQKLEAAGFRRDYFEIRAQENLQTPSEEEKRLVILTAAYLGKARLIDNLRVEL
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
A6W2I4
Q63532
SPR1A_RAT
Small proline-rich protein 1A
Rattus
MSSQQQKQPCTVPPQLHQHEVKQPCQPPPQEPCAPKTKEPCHPIPEPCNPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCHPKAPEPCHPVVPEPCQPVAPEPCQPVVPEPCPPTVTPSPYQQKTKQK
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Q63532
Q2P377
PANB_XANOM
Ketopantoate hydroxymethyltransferase
Xanthomonas
MSSHADSNPWTVPALAQAKRAGRKLVMLTAYDASFARTFDANGVDLILVGDSLGMVMQGHDSTLAVTTADMVYHTAAVARALDRALLVADLSFQADATPERALDAATQLLQAGAEMVKIEGAGHKLEVIRYLVEREIPVCSHLGLTPQSVLRFGGYKVQGRGEAGEQLRRDAQAVVDAGASLVVLECVPTPIATQISAELSVPTIGIGAGPGCDGQVLVMHDMLGLDSGHRRPKFVKDFLAEGGSVAGAVRAYAQAVRDGSFPDAEHAYAA
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q2P377
Q9GMY2
PEPC_RABIT
Pepsinogen C
Oryctolagus
MKWLLVALVCLHLLEAAVIKVPLRKFKSIRETLKEKGLLKEFLNTHKYDPALKYRFGDFSVTYEPMDYLDAAYFGEISIGTPSQNFLVLFDTGSSNLWVPSVYCQSEACTTHNRFNPSKSSTFYTYDQTFSLEYGSGSLTGFFGYDTFTIQNIEVPNQEFGLSETEPGTNFLYAEFDGIMGLAYPSLSVGDATPALQGMVQDGTISSSVFSFYLSSQQGTDGGALVLGGVDSSLYTGDIYWAPVTRELYWQIGIDEFLISSEASGWCSQGCQAIVDTGTSLLTVPQEYMSDLLEATGAQENEYGEFLVDCDSTESLPTFTFVINGVEFPLSPSAYILNTDGQCMVGVEATYLSSQDGEPLWILGDVFLRAYYSVFDMANNRVGFAALA
Hydrolyzes a variety of proteins.
Q9GMY2
Q49Y40
MTNN_STAS1
S-adenosylhomocysteine nucleosidase
Staphylococcus
MIGIIGAMEEEVAILKDKIVNLEIINVAHVVFYKGRLHDKEVILTQSGIGKVNVAISTTLLINRFHPDLIINTGSAGALDKSLGVGDIIVSDMVAYHDADARAFGYQLGQIPQMPAQFVADSHLIELAKEAINDQKWVAKSGLIVSGDSFIGTAEQRADIKTNFPQAMAAEMEATAIAQTCYQFNLPFIITRAISDLADGDAGITFEAFLEKAAIASSQIVDRLIKTI
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
Q49Y40
Q7T1M3
BNP_BOTJR
Bradykinin-potentiating peptide Va
Bothrops
MVLSRLAASGLLLLALLALSVDGKPVQQWAQSWPGPNIPQLLVQQWAQGGWPRPGPEIPPLTVQQWAQNWPHPQIPPLTVQQWAQGRPPGPPIPPLTVQQWAQARPPHPPIPPAPLQKWAPVQKWAPVQKWAPVQKWAPLLQPT
Acts as indirect hypotensive agent. Potently induces vasodilation of arterioles, with only a small increase in leukocyte rolling flux.
Q7T1M3
Q01651
G3P_CORGL
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
Corynebacterium
MTIRVGINGFGRIGRNFFRAVLERSDDLEVVAVNDLTDNKTLSTLLKFDSIMGRLGQEVEYDDDSITVGGKRIAVYAERDPKNLDWAAHNVDIVIESTGFFTDANAAKAHIEAGAKKVIISAPASNEDATFVYGVNHESYDPENHNVISGASCTTNCLAPMAKVLNDKFGIENGLMTTVHAYTGDQRLHDAPHRDLRRARAAAVNIVPTSTGAAKAVALVLPELKGKLDGYALRVPVITGSATDLTFNTKSEVTVESINAAIKEAAVGEFGETLAYSEEPLVSTDIVHDSHGSIFDAGLTKVSGNTVKVVSWYDNEWGYTCQLLRLTELVASKL
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Q01651
C1EXK2
RBSD_BACC3
D-ribose pyranase
Bacillus cereus group
MKKHGVLNSEIASVLASLGHTDTIVIADCGLPIPAGVKRIDLAVEIGKPSFLDVLQVVADDMAIEKVTLAEEVINNNAEVNKEIELKLIEPAFEYVCHEQFKEHTKKAKAIIRTGEATPYANVILHAGVIF
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
C1EXK2
Q06GY8
ACCD_DRIGR
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic
Drimys
MEKWWFNSMLSNEELEHRCGLSKSMNSLGRAIGNTSGSEDLIINDTDKNIHSWSDSGSYSCNNVDDLFGIRDIWSFVSDDTFLVRDSNGDSYSVYFDIENQIFQIDNDSSFLSELESSFSNYLNFSYLNSGSKSDNRYYDRYMYDIKYSWNNHINSCIDSYLHSEISIESYISSSSDNYGDSYISSFICNESVSVSDNGSSSIRTSGNGSDFNIRGRSNDFDINQKYRHLWVQCENCYGLNYKKFFRSKMNICEQCGYHLKMSSSDRIELSIDPGTWDPMDEDMVSIDPIEFHSEEEPYRDRIDSYQRKTGLTEAVQTGIGQLNGIPIAIGVMDFQFMGGSMGSVVGEKITRLIEYATNGSLPIIMVCASGGARMQEGSLSLMQMAKISSASYNYQSNKKLFYVSILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGKRVIEQTLNKTVPDGSQAAEYSFHKGLFDSIVPRNPLKGVLSELFQLHGFFPLNQN
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Q06GY8
Q8XVC2
OPGH_RALSO
Glucans biosynthesis glucosyltransferase H
Ralstonia
MELPATSGLNAQPGNAEGTTASTRPATALSVAERYLEALPLPAEARAALRREAGIEPADKDAVALAKLHRALARLDAAQTASIEGSVPAYASIGSRLDAAYGTPHAGTATPEPAPPLEHDTAGRIHLDTGPEPARRSMVPWPWVLGPIWRARRAIGRLFSGGTAPVPYEQPDSPDPKGIWRFVGARRRLTLLALMIAQTVAATWAMSSVLPYHGHDWLEAIIIALFALLFCWVSAGFWTAITGFLLLAFHGDRFVISRRAAPNAPIPDDARTAIVMPICNEDVQRVFAGLRATYESLQRTGHLEHFDFFVLSDSGDPDIRTAEADAWLHVCRALDGFGRVFYRWRRHRVKRKSGNIDDFCRRWGGRYRYMIVLDADSVMSGDCLTRLVQLMEGAPSAGIIQTAPLAAGRDTLYARIQQFATRVYGPLFTAGLHYWQLGESHYWGHNAIIRLEPFIKHCALAPIPGKGSLSGEIMSHDFVEAALMRRAGWAVWIAYDLDGSYEEMPPNLLDELGRDRRWCHGNLMNFRLFGSPGFHPVHRAVFVTGVMAYLSAPLWFLFLLLSTALLAKHTLIAPEYFTQPRQLFPIWPEWHPEKAAALFSATATVLFLPKILSVLVLWAKGPRRFGGAVHLALSMVIEAVFSVLAAPVRMLFHTRFVTAAFLGWKVHWKSPPRDDAQTHWGDAVRRHGLHTLLGLGWAALVYWLNPSFLWWLSPVVGALIVSILLSVFSSRVTLGRGMRRWRLFMIPEEVRPPRELRAMRKHLRQAPPTPDFRLAVVDPVTNALMCAIGTARFPHDPKLLEVRDATVLQALAAGPDKLTSKQKLVLLSDPLALSALHLAVWSSDVHRAAWLPANALASKAAA
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Q8XVC2
Q03SK6
UNG_LEVBA
Uracil-DNA glycosylase
Levilactobacillus
MKPFIHNDWWPVLEPEFEKPYYQELRRFLVEEYQHYRIDPDMYHIFTAFEWTPFSQVKVVILGQDPYHNPGQAHGCSFSVLPGTEIPPSLVNIYKELQDDLGVQPVQHGYLKHWADQGVLLLNSVLTVRDGIKTANTHRGHGWEQLTDSAIEKLSARPEPVIFILWGSAARSKIKLIDTQTNIVLQSPHPSPLSAYRGFFGSKPFSKTNIALTSLGETPIDWQLPQQVTISDESTSDTH
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Q03SK6
A8GDC2
PEPT_SERP5
Tripeptide aminopeptidase
Serratia
MDKLLDRFFNYVSFDTQSKANVKHVPSTDGQMKLARALQQEMIELGFERVSLSEHGCVMGTLPGNVAWSVPAIGFISHLDTSPDFTGKHVNPQIVESYRGGDIALGIGDEVLSPVMFPILHQMLGQTLITTDGKTLLGADDKAGIAEILTAMVRLQQRNIPHGDIRVAFTPDEEVGKGARFFDVAQFNAEWAYTVDGGGVGELECENFNAASVTVKIVGNNVHPGSAKGVMVNALSLATRIQQALPADETPETTADYQGFYHLSSLKGSVERAEMHYILRDFEREGFEARKRRMFEVAKQVGKGLPRDCYIEVTIEDSYYNMREQVAEHPHVIALAQQAMRDCDIEPVMKPIRGGTDGAQLSFRGLPCPNLFTGGYNYHCKHEFVSLEGMEQAVAVIMRIAALTAERAK
Cleaves the N-terminal amino acid of tripeptides.
A8GDC2
Q0CRW7
STTB_ASPTN
null
Aspergillus subgen. Circumdati
MSISNMTSTVWPDLQVPAIEHNHLPILTVALLTGIASAVYINVSSVQDPCKVGSIPTVKRPRLLDAYRSGVWWRIFVPRLVPYIEEGYHKYNKNDQPFRIWLGGFQAYAYVLPERYLDKIKNMPESEASFAAMANKYFHTGLPTGEVNNLVLQVASKLVNGNLATIKTLMQGEVQKALAREIGSPRQWTKINAWQVARKTTEAPGLRVVFGEELANDKTFVTGVSEFVSNITVYAFTLRYINLGPLRDFILYLVHWRHRRSLPAVLTPLNNVITERKKVRSNRHISDDEESFDCIQWALDQPVSDDCKTAEAIARRLVVISLGTIDTVAGVLVKQLTHLASHPECHEEIRAEIRECLAEDDNGWTLKSTGRMKKLESFIQESLRMSSGAISLSGMRIVTGSGFRLDDNTVLPRDSFIAIPTRNILYDPEVFPEPEKFDPFRFYKIKEDEKNAGSRSNRRDIRASWLAFGYGRQACPGRFYAINAMKTILGEILLKYDIRLAEKQAPRIDIDLDPMLAPVRSTDLEFRVRA
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspterpenacids . Performs the C22-oxidative modification of the terpene synthase sttA product preaspterpenacid I to produce preaspterpenacid II . It has still to be determined how preaspterpenacid II is further modified to produce aspterpenacids (Probable).
Q0CRW7
Q9HB20
PKHA3_HUMAN
Phosphatidylinositol-four-phosphate adapter protein 1
Homo
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane . Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration . Binds preferentially to PtdIns(4)P . Negatively regulates APOB secretion from hepatocytes .
Q9HB20
Q72PL0
RL20_LEPIC
50S ribosomal protein L20
Leptospira
MPRAVNGTIHKNRRRRILKDAKGFRGARSKLYRTAKSAVMKAGQWAYRDRRAKKRDFRKLWIIRINAAARENGLSYSVFMNSLKKLGIHMDRKSLAELAFNDREVFNSLVEKIKVAG
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Q72PL0
Q98C03
DHAA_RHILO
Haloalkane dehalogenase
Mesorhizobium
MSSKANPPQPVATAPKRSQIPILDSTMSYVEAGASGPTVLFLHGNPTSSHIWRNIIPHVAPFGRCIAPDLIGYGQSGKPDIDYRFFDHVRYLDAFLDALDIRDVLLVAQDWGTALAFHLAARRPQRVLGLAFMEFIRPFERWEDFHQRPQAREMFKALRTPGVGEKLVLEDNVFVEKVLPASVLRAMSDDEMDVYRAPFPTPQSRKPVLRLPREMPIEGQPADVAAISAHDHRALRLSTYPKLLFAGDPGALIGPQAAREFAAGLKNCSFINLGPGAHYLQEDHADAIGRAIASWLPEVVLANQTDELA
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Q98C03
Q9UHV7
MED13_HUMAN
Vitamin D3 receptor-interacting protein complex component DRIP250
Homo
MSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSVQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKFPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQCLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGPSMPFIKEGDGSNMDQEYGTAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTVTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Q9UHV7
Q501F9
P2C67_ARATH
Probable protein phosphatase 2C 67
Arabidopsis
MVKPCWRIGAGMERSKINPTKVDGLTWYKDLGLHTFGEFSMAMIQANSVMEDQCQIESGPLTFNNPTVQGTFVGVYDGHGGPEASRFIADNIFPKLKKFASEGREISEQVISKAFAETDKDFLKTVTKQWPTNPQMASVGSCCLAGVICNGLVYIANTGDSRAVLGRSERGGVRAVQLSVEHNANLESARQELWSLHPNDPTILVMKHRLWRVKGVIQVTRSIGDAYLKRAEFNREPLLPKFRLPEHFTKPILSADPSVTITRLSPQDEFIILASDGLWEHLSNQEAVDIVHNSPRQGIARRLLKAALKEAAKKREMRYSDLTEIHPGVRRHFHDDITVIVVYLNPHPVKTNSWASPLSIRGGYPMHSTS
Dephosphorylates and represses plasma membrane H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), thus influencing negatively plant growth and fitness . Promotes the apical hook maintenance of etiolated seedlings .
Q501F9
Q8PGW9
RSGA_XANAC
Small ribosomal subunit biogenesis GTPase RsgA
Xanthomonas
MSDTSPDYPTLQSIGWPWLGPPEEAAWQAVFAAHPQALPARVVEQHRTGYVVADTPEASVKAESLPEWQRPRFPSHERAAVGDWVLMEGKRIVALLPRRTSIKRGAAGEHYHQQVIAANIDTVFIVCGLDADFNPRRIERYLLLVGGGGAQPVVVLTKADQTEYAEDALAVLEELEAQNIPLRAVNAKDPDSVAALRPWLGDGRTAVLVGSSGAGKSTLTNTLLGTQKMKTNAVRENDSRGRHTTTHRALIPLPSGACLIDTPGMRELKPTGEEDLAEGGFSDVEALAAQCRFNDCAHIAEPGCAVRAAIDAGELDPERVANYMKLRMEVASAAEKLATRVAQNNRGKGSGKRPASVDRPGRH
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
Q8PGW9
A9N2D8
CYSN_SALPB
Sulfate adenylate transferase
Salmonella
MNTILAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTLQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCDLAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYREETFARIREDYLTFAEQLPGDLDIRFVPLSALEGDNVAAQSANMRWYSGPTLLEVLETVDIQRAVDRQPMRFPVQYVNRPNLDFRGYAGTLASGSVKVGERIKVLPSGVESSVARIVTFDGDKEEACAGEAITLVLNDDIDISRGDLLLAANETLAPARHAAIDVVWMAEQPLAPGQSYDVKLAGKKTRARIEAIRYQIDINNLTQRDVESLPLNGIGLVEMTFDEPLALDIYQQNPVTGGLIFIDRLSNVTVGAGMVRELDERGATPSVEYSAFELELNALVRRHFPHWDARDLLGDKHGAA
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
A9N2D8
O60238
BNI3L_HUMAN
NIP3-like protein X
Homo
MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
O60238
Q8CMP5
METE_STAES
Methionine synthase, vitamin-B12 independent isozyme
Staphylococcus
MTTIKTSNLGFPRLGRKREWKKAIENYWAHKIDKAELDQTLTDLHKENLLLQKNYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGREVNDDLLFDIARGNKEHVASALIKWFNTNYHYIVPEWDNVEPKVEKNTLLERFKYAQSINVNAHPVIVGPITFVKLSKGGHQSFEEKVETLLPLYKEVLQSLVDAGAEYIQIDEPILVTDDSESYEDITRKAYDYFANEGLGKYLVIQTYFERVHLKFLSSLPVGGLGLDLVHDNGYNLKQIEDGDFDQSKALYAGIIDGRNVWAADIEAKKQLIETLQQHTQQLVIQPSSSLLHVPVSLDDETLDESIAEGLSFATEKLDELDALRRLFNDNDLSKYEHYKARYERFQSQSFKNLEYDFESVPTHRKSPFAKRKQLQNQRLNLPDLPTTTIGSFPQTREVRKFRADWKNNRITDAEYQEFLQNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPVIYGDVKWTAPLTVKETVYAQSLTDKPVKGMLTGPVTILNWSFERVDVPRKVVQDQIALAIDEEVLALEEAGIKVIQVDEPALREGLPLRSEYHEQYLEDAVHSFKLATSSVHDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIQDFEDINYDLGIGLGVYDIHSPRIPTEEEITTAINRSLQQIDRSLFWVNPDCGLKTRKENEVKDALTVLVNAVKKKRQESESTTA
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Q8CMP5
Q60695
RGL1_MOUSE
Ral guanine nucleotide dissociation stimulator-like 1
Mus
MKLLWQAKMSSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGPNCEDDGSQSSPESKAVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLEYLKQMMPGSDPERRAQNLLEQFQKQDVDSDNGLLNTSSFSLEEEEELESGGSAEFTNFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSQRDKKENKHLAPTIRATISQFNTLTKCVVSTVLGSKELKTQQRARVIEKWINIAHECRILKNFSSLRAIVSALQSNSIYRLKKAWAAVPKDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMGPDQKFIQWFQRQQLLSEEESYALSCEIEAAADANTTSPKPRKSMVKRLSLLFLGSDIIPGSTPTKEQPKSAASGSSGESMDSVSVSSCESNHSEAEEGPVTPMDTPDEPQKKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPTCNNNPKIHKRSVSVTSITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMSKHNLESDPAEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSVEEQVKLRSRTSLTLPRTAKRGCWSNRHSKITL
Probable guanine nucleotide exchange factor.
Q60695
Q8EUW7
SYP_MALP2
Prolyl-tRNA synthetase
Malacoplasma
MSKIVKQEENFSKWYTSIIENANLVDYGLVKGTIMFKPYGFAIWKRIQEEFNKILVSLNTAEVCFPMLIPYSEFMKEKEHVEGFNPELFKVSHLGEKKLEDELVIRPTSEISFCNYFKKNIKSYNDLPCILNQWGSVFRVEKNTRPFLRTSEFLWQEQHAVFADKKEAFDFSITMVNEYKKFVNDYLSIAVLMGEKTENERFAGADNTFTIEALMPDGQVLQSATSHYLGTNFAKSYDLKYQTKNNNYDLMFQTSAGLSTRIIGAIIMSHSDNNGLVLPFKIAPIQFAIVTSNEVNKDSDELKAIYKNLFGYKYQTYFVEKSLGLQLQENEIKGIPFQLILGKKEIENNTITIYRRDTREKQNISFKEFNQNFIENLIKEYSSNLFNKTEKRLNSSIEFVNNIDEFKKALDNKKIISAYWSGNAEDEKKLKELTTATPRCFDWNQKIDKTKKCFFTNKPNAKLVYFARAY
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Q8EUW7
P13613
LACB1_EQUAS
Beta-lactoglobulin I, major monomeric
Equus
TNIPQTMQDLDLQEVAGKWHSVAMAASDISLLDSEEAPLRVYIEKLRPTPEDNLEIILREGENKGCAEKKIFAEKTESPAEFKINYLDEDTVFALDSDYKNYLFLCMKNAATPGQSLVCQYLARTQMVDEEIMEKFRRALQPLPGRVQIVPDLTRMAERCRI
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
P13613
Q5ZM36
IF4A3_CHICK
Eukaryotic translation initiation factor 4A isoform 3
Gallus
MSGSAGSGGTTGSARKRIMKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
Q5ZM36
Q86L99
GACHH_DICDI
GTPase activating factor for raC protein HH
Dictyostelium
MSWSSIKLSRLPDATISVWGHTATISGEKDIVIFGGFDFCIEKPTNTTYILHTSQTNGLTKPSVSGSLPPPIYGHSSTQVGRKMFVFGGSLQDNVQVNDMYQFNTSNYSWSKPRPMGEPPIPRYGHSASLIYDNYILIFGGNNTKSSKPLNDIHIFNTERNSWTKPSSNSSTGEIIFNPHDISPRSSTTTPTHQSVNGSNSNSSSSSRVRSATISSHNNSPIVMPLNNNNNNNNNSNNSNNSNNNGGGSPMTTPPTLQQLHLSQLMANGIGMGGSISNGNSDSPPLTPSMMALESSMLNGFKSPLSLSQRLLRSGFRSSPPSARYFHSCSVINGKAFIFGGYNGTTLLNDLYILNIESMEWICPHTKGDLPTPRAGHTSIAIGSRLFIFGGTIEGDPSSSNAHCDNDLYMFEPELNYWTLLKTSGTLPSPRTGHVCLPISSKILIIGGSDAILNNKLKLSNTYHSLETLKLDFSHYSRGGSGGGSNNNIIIHPITSSNSTSSNSIITNYLPHLKPRSSSNSGGGGGSITNTPTTSSLHIKDNSASPSPLTPRSIARNSPKSSIFHDNINNNSNNNLLNTLQEASKFELSPGTPKSIRGIDSLSSVSLTQSIDRNGGSGGGSGGGNGVVSNDRGEFLRHYTTQSILINKNNNNNNNNNSGGSNLSISSNSGSNNSINSNDGLVLQCSTPLCIKKYNSLKDSYLELKQKYQEEREKRLELEKELERYRLSSPITSASSLVDTLSSPNNLNINSNNSTTTTTTTTTTTTTPIPLSTSNNNNNNNNNSTLTVQDQVTTSKQILEIYEDIYNLWGYYEKRVKWKENTEKEANQQLEVIKSKIDLFTSMVGLENHFSFNDDTKSCCSENINGDHNQQQQQQQQQNPQFQIDDNISETNSQISEPALIHETLTPRKSRENSVHHSRSVSNPIPLLSQIVKQSKSGDSTLTVPQQLHSSHNNLIQLASISTPQKPPQQPQQQQQQQPPQENGKEPSKSTQKIFKLLISKKNRASGHFKLSSSNESSNSEETTPTFSNNPNLINDEDDDSQQHQQQTNIGSNSISNINTSNSTTSLSSSVSSTSLQTQEEFEASERSKQKKRLGKALKQMINKDRQLKETAAAALAVSNSNGNLGGGGGGGSINGTTNVSGNGANNLGGLVLTSDKEKEKLEKEREKSERIEREKQEKEREKLEKEREKSERIEREKLEKAEKERLEKEKIEKEKLEKKHKKIKGLFGAKSSNKESLPFRRDVIEKVINHLRENSLDTEGIFRLSGNMESVRGIVKSFAHGEPNLSFEVHNISNALKHYLRSLDPPLIPYEFFLMLLDARKNEDAETIRNIFWKIPSDNRVVLTLLVDLMVKISENSNVNKMNSKNLSIVFGPTILKPRTPTLDRMALMTETQLQCGIIQTFIEDFHYIFSEFPTSGPKSFLGDDDYDSSSFGSNNTPSSHSPHSSSPTLNPAVTTTTTTTTTTNTTTTTNTTTTPTSATISPNIIQTNNCDSALCTPTTLSSTAAIIQSNNNNRTDSNRNN
Rho GTPase-activating protein involved in the signal transduction pathway.
Q86L99
Q04865
TF65_XENLA
XRel1
Xenopus
MDGFHWTDIVSSMPPSIPPVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTSKTHPTIKINNYQGPARIRISLVTKDSPHKPHPHELVGKDCKDGYYEAELSPDRSIHSFQNLGIQCVKKREVEDAVAHRIRTNNNPFNVSPEELKADYDLNTVCLCFQVFIPDQAAGRMLPLPFVVSQPIYDNRAPNTAELKICRVNKNSGSCLGGDEIFLLCDKVQKEDIEVIFGLGNWEARGIFSQADVHRQVAIVFRTPAFQDTKIRQSVKVQMQLRRPSDKEVSEPMEFQYLPDEGDPHHIDEKRKRTLDNFKHYVKNNPFAGGETRPQRRIAVANRNVPTKSEPIRPSIPVPNPVVSCLPFSMPVLKAENVTSPSTLLSTVNISDFSNLGFSSQPPSQSDHDRLESMLNYPSFPGDANLDLVEMLPHENESRCTSLSSIDNSDFSQLLSESQSSGTLSAALQEPGTSQGTFMAYPESIARLMTNRPNEDEGGERIDSGLINGMFDISREEIHLTSLFELDFSSLLSNMK
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.
Q04865
Q9GYF0
CHUP1_CAEEL
Cholesterol uptake protein 1
Caenorhabditis
MRTSQAIFILIFLDSVRNQSPQVIPAKWDVVYEKETGHNMSLTVFRFQVKEQYSVARIIMSCNESTEHNPLLAVFREKLAILSLQVPLIVDNYEYSQVARTLCPFTEYKEGEAFTVEVTSSRPVHYNFRAELVQNFYLYNNSQRLVTASASEPVYLRYDIPGDVDSVAVHLDSNSTICMTVSVQKIGCPVFDLPDNVNSMGLHQTMTTSATIPVEKSRMSSFYVVFVVNTNDDLCSEILSIKPNKPTKFPLRMKSFNVTIESSMKIFDYTIPIVFWACILLLVTIVVFVYHYFDGIWERRFVSRAYTHLEDNAQEQRIRDFYDFQRMSEDDDLKDYDLLTDCQDMMVVRAKASLTVADLSMTPYEERELKYDVYKIALAIIGIFYNITVLQLIISKAGSLRQSGDLDECTFNFQCARPLWYFVAFNNVVSNGGYVYFGTLIIVMNYCRERSFRRLFAVQPTLAERYGLPQHSGLMTAIGLAVIMEGISSATYHVCPNNINYQFDTALMYVIGMLGKLKIWSLRHPDMVVSAYHAFGFLGVFLMAAIAGVYVHNMIFWALFSIIYIASMLLVSLEFYFKGIWTLNLRELRNSIRLSWVSSRHLSCVVPAYKARFFVILLLNIANTAVVVYGLEAHPKDFLSFLLIPFIGNLFIYIIYYILMKMIYREKIPKRAIALLFAAVISWTCAGILFNQRVSDWSKMPAISRELNKPCIFLNFYDNHDLWHLSSAFAIFFSFTAINVIDDDLMFVMRNTIRVF
Cholesterol-binding protein which is involved in dietary cholesterol uptake from the environment . Does not play a role in double-stranded RNA transport in contrast to other SID1 family members .
Q9GYF0
C0PYG5
LEPA_SALPC
Ribosomal back-translocase LepA
Salmonella
MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDFKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVTDVLERLVRDIPPPQGDPDGPLQALIIDSWFDNYLGVVSLVRIKNGTMRKGDKIKVMSTGQTYNADRLGIFTPKQVDRSELKCGEVGWLVCAIKDILGAPVGDTLTSARNPAEKALPGFKKVKPQVYAGLFPVSSDDYESFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTAKETIYVDSPSKLPPLNNIYELREPIAECHMLLPQAYLGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINNERVDALALITHRDNSQSRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
C0PYG5
P32188
EPD_ESOLU
Ependymin
Esox
MQAFAVAALSIWLCLGATTLAESLAQSHGPQHCTSPNMTGVLTVMALNGGEIKATGHYHYDTTDKKLRFTESDMHLNKSEHLEDYLMLFEEGVFYDIDLKNQSCRKMSLQSHAHALELPAGAVHQVELFLGSDTVQEENIKVNIWMGSVPETKGQYSVSTTVGDCLPLSTFYSTDSITLLFSNSQVVTEVKEPEVFSLPSFCEGLELEDTHNDFFSIFNTV
May play a role in neural plasticity. May be involved during axon regeneration.
P32188
Q6P280
ZN529_HUMAN
Zinc finger protein 529
Homo
MANSSFIGDHVHGAPHAVMPEVEFPDQFFTVLTMDHELVTLRDVVINFSQEEWEYLDSAQRNLYWDVMMENYSNLLSLDLESRNETKHLSVGKDIIQNTGSQWEVMESSKLCGLEGSIFRNDWQSKSKIDLQGPEVGYFSQMKIISENVPSYKTHESLTLPRRTHDSEKPYEYKEYEKVFSCDLEFDEYQKIHTGGKNYECNQCWKTFGIDNSSMLQLNIHTGVKPCKYMEYGNTCSFYKDFNVYQKIHNEKFYKCKEYRRTFERVGKVTPLQRVHDGEKHFECSFCGKSFRVHAQLTRHQKIHTDEKTYKCMECGKDFRFHSQLTEHQRIHTGEKPYKCMHCEKVFRISSQLIEHQRIHTGEKPYACKECGKAFGVCRELARHQRIHTGKKPYECKACGKVFRNSSSLTRHQRIHTGEKPYKCKECEKAFGVGSELTRHERIHSGQKPYECKECGKFFRLTSALIQHQRIHSGEKPYECKVCGKAFRHSSALTEHQRIHTGEKPYECKACGKAFRHSSSFTKHQRIHTDDKPYECKECGNSFSVVGHLTCQPKIYTGEKSFD
May be involved in transcriptional regulation.
Q6P280
Q3MEE5
KAIB_TRIV2
Circadian clock protein KaiB
Trichormus
MNKARKTYVLKLYVAGNTPNSVRALKTLKNILEQEFQGIYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRERVLIGLDLLYEELTEEDWEAQSSL
Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.
Q3MEE5
Q8GUK1
DGS1_ARATH
Protein DGD1 SUPPRESSOR 1
Arabidopsis
MDSQPPVNESTPSTALSNFGELVPFYSSYLWNRLASLLPTSKPIFLGKISNLYRQTVSRKRSISFPLPLPSDFPSSSTITSNVSADTARIHGVLEEIMADVLSNLHDIQKSLDFWRSRAEGSNARKAYFMIFERGPTAFVNESTKFVSKSLSEDSAMQHLCQSSSSHMTERMRVLVELRSALASFIAQLYVELDKRGEDLVKIPEKALPSLLAVINGLFSNLEGSFSHLHAVRECDSSVDGSYPMPLVFDRLPEVNEEGSQWTDCELTDAINLVHKNLEKLNSYLSVMVGKHRKPRRMTLYWVRYTCGAVGLSVFSIWLLRHSSLMGSSDIENWVHDAKEATMSFFSDHVEQPLLSIRDELFDTFRKRHKGVMETEEVQLTQDSLHRMLRNFCEQATREKVPDNASDQEMLEVVMNRYEKELVHPIHNLLSGELARGLLIQVQKLKLDIETAMLELDQILRANEINFAILAALPAFFLSIVMLTVLRTWLKKDSKAQGRGRIARIHRRLLVVEIEKRIMQYQSYIEQGRDKDAETVFGLLIYSLERLYRVVEKPARATDEWDLVKQDLIELGRPQQQTSYKLTVTQRLVTVYDCLLPTLKRQ
Involved in galactoglycerolipid biosynthesis. May contribute to an intracellular signal that regulates an alternative DGD1-independent galactoglycerolipid biosynthesis pathway in chloroplasts.
Q8GUK1
Q253Y0
RSMH_CHLFF
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Chlamydia
MSEAPQHIPVLVNECLSLFADRNPKFFCDVTLGAGGHAEAFLSAYPSIVSYDGSDRDTMALSLAKERLEKFGNRVHLHHASFEDLAQNPRENVYDGILADLGVSSMQLDTLSRGFSFQGDDHDLDMRMDTSKGTTASEVLNTLREEDLGRIFREYGEEPQWKNAAKAIVQFRRHKKIITVRDLKEATTRVFPSYRLRKKIHPLTLIFQALRVYVNQEDVQLKVFLESAMRWLAPEGRLIIISFCSSEDRPVKWFFREAEAMGVGKILTKKVVMPTYEETRKNPRCRSAKLRCFEKKSS
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Q253Y0
Q52955
ILVC_RHIME
Ketol-acid reductoisomerase type I
Sinorhizobium
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAQNVAIALKSGSATAKKAEADGFKVMTVAEAAAWADLMMMATPDELQADIYKADIAGNIRDGAAIAFAHGLNVHFGLIEPKASVDVVMIAPKGPGHTVRGEYQKGGGVPCLVAVHQDASGNALDLALSYACGVGGGRSGIIETNFKEECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEWGEYVTGPRIITEDTKAEMKRVLKDIQTGKFTSEWMQEYRSGAARFKGIRRVNDSHQIEEVGAKLRAMMPWIGKNKLVDKAKN
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Q52955
Q5QY69
TMCA_IDILO
tRNA(Met) cytidine acetyltransferase TmcA
Idiomarina
MAERSGYRQLQLLQDASLWREYCEARSESSIYLSNLQTHADAVLSRYRDYLGHEFEQVWIDCHDGLHADAIAALCGTVTAGGLLSILLPAESNAMSHRMERFAAKHFAESNIKPYSSVNKTETRSANETLQLTNEQNSIFNALTQSTAKPYETHIITAERGRGKSTLLGQALAQAKEHRSIIVTAPRKANAKVLLQQAPEAHFVAWDKLLEQPGNSEVTLIIDEAAGLPLWATEQLCQKFNPWLLATTVAGYEGCGRGFAVHFTDWARKTLPQVSVHQLTQPLRWPANDPLEQWLTETFLLNEQPVTQFGNRESGTFIKHASELEEALLQQCFQLLLSAHYQSSPNDLNLLLTEPGHKLAYQSTNGEVTAVAWLMSEGPILSPLKEEVRQGQRRPKGNLLPQAIGYFLQQDWAMDLHWLRVARIAVPAAKRRRKAASELLAEIYRWALDNNYQMLGTSFAWSPGLDNFWKKNGYALWRLSSRIDSVSARPAAIYALPLTNEFTELYRVCQLLGQWGQNQLQWLSGGKETLQLTEERNKIRTSLIQAYRSKTIPFDAAHFALAQWFYWQHSNHPLTELLCNSSTTLKHLGEYWGGVSQRQANENLCKEVCLLH
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
Q5QY69
Q20351
TPSTB_CAEEL
Tyrosylprotein sulfotransferase
Caenorhabditis
MRAILDAHPDVRCGGETMLLPSFLTWQAGWRNDWVNNSGITQEVFDDAVSAFITEIVAKHSELAPRLCNKDPYTALWLPTIRRLYPNAKFILMIRDARAVVHSMIERKVPVAGYNTSDEISMFVQWNQELRKMTFQCNNAPGQCIKVYYERLIQKPAEEILRITNFLDLPFSQQMLRHQDLIGDEVDLNDQEFSASQVKNSINTKALTSWFDCFSEETLRKLDDVAPFLGILGYDTSISKPDYSTFADDDFYQFKNFYS
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Q20351
A1TJ16
RS17_ACIAC
30S ribosomal protein S17
Acidovorax
MTEAKKSLKRTLVGKVVSDKREKTVTVLVERRVKHPIYDKIVIKSSKYHAHDENSEYKLGDTIEITESRPLSKTKNWVATRLVQKAALV
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
A1TJ16
A5VWQ6
ENGB_PSEP1
Probable GTP-binding protein EngB
Pseudomonas
MQVKNPILGLCQKAKFALSAAKVEQCPDDQGYEVAFAGRSNAGKSSALNTLTHASLARTSKTPGRTQLLNFFSLDDERRLVDLPGYGYAKVPIPLKQHWQKHLEAYLGSRECLRGVILMMDVRHPMTDFDKMMLDWAKASSMPMHILLTKADKLTHGAGKNTLLKVQSEIRKGWGDGVTIQLFSAPKRLGVEDAYRVLADWMELEDKPVI
Necessary for normal cell division and for the maintenance of normal septation.
A5VWQ6
O00874
DPOLA_LEIDO
DNA polymerase alpha catalytic subunit
Leishmania
MSGGNDGASWRLSRKPNAPNFDETQEDQWRSLREEVLQSDEDENIPESGDLTIPQLPSAKKAAKKLRKPPSGAKPTPKPKQQTLAQSMSDMDMERLLKRYRIDEDIDIAEDIDMSHLLQLHSDSDDGGDAQEATLTADEFLARLARAEAAPAASIAKEKRESGENVTVVALKDELFNVERDQSAKPPRPRPTPGAGGGAGYRNEETPKQAIELTATLAPQMDAAQFVSPAVPYKSGEMTEGLFYWFDAREQPHTLSVDPGSLFLFGKMAVEKNGRTSYLSCCVRVRNMYRSVFVLPKAGSSQEDVVKEINDICRNQGIEQRRIKFVERYYAFEVPGVPHEKTQWAKLRYPGRYPPLNAKGPFRHILIIMGASSSLLELFLIKRKLKGPSFLRISGLVASANRISHCALEFSVESPKNLRAEDTKLPVPPFTLASIQIHTQLDSKGACNEILIASVAIYKDVNIENTIRYIPDNILTGVRPASMSTPLPIDLESYCSAKGLPGVRRFANERALLDWLAQQLGKIDADMMIGHNFLGFTLDILLRRYQELSISSWSTIGRLDLKRLPRFQGTATNVNQEKETCIGRLVVDSYSLSREHYKTVNYRLLSLADQMQLQGITKGSNNFEPGTSVLTPAMLSASRDIYDVLLQVCNCAVLSTAVVSHLDVIRLTKRLTTIAGNLWSRTLFGARSERIEYLLLHTFHDLKFITPDRYVQNFKRGRDDEEEEDGKRKAKYQGGMVLDPKCGLYSDYILLLDFNSLYPSLIQEFNICFTTVDRESGSEIDVPPPENLICASCAAAGLSAPCLHKCVLPKVIKSLVDSRREVKRLMKIEKDANNLALLEIRQKALKLTANSMYGCLGFEYSRFHAQPLAELVTRQGRLALQSTVDLIPQLNPSLRVIYGDTDSVMIQTGIKNDIKAVRDLGLDLKAKINKRYQSLEIDIDGVFRAILLLKKKKYAALTVTDWQGEGKTYKKEVKGLDMVRRDWCPLSKCVCDSVLSRVLNAEGSEDILDYVMNYMRDVSEKVRAGRYTLDNFVISKSLTKEPEAYRGNSFPHATVALRMKQRKELVRVGDLIPYVICTGDRLSDKAFHVEEVRQNSQLQIDSEWYLSVQIYPPVMRLCEHIQGFSNAQLSEAMGIACHTGAKLEEEEAETMNDFSHSSLFQSRNLEECFPAALSLQVACTHCRLMTPINPHTRVMEVLADQERQRDRFDLYVCVSCRKSLPVDYVANCFTQTCYGIIRQFYQCGSAAAVKAVRTQFTYYRALFDVPHAPGCPARVKDAHYYQARRCLGVDRRLYTLAEAADPAVQEVADPVDPLNAAAETIYKRIDHLFINLDSLFAGI
Polymerase alpha in a complex with DNA primase is a replicative polymerase.
O00874
B0VQB8
DXS_ACIBS
1-deoxyxylulose-5-phosphate synthase
Acinetobacter calcoaceticus/baumannii complex
MPHMLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLGVVELTVALHYCFNTPNDRLVWDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAMTAGMAFEAMNDAVAHDADLIVVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDAADNLFKAIGFDYFGPFDGHDVTQLVQVFNVLKKRKGPRLVHVYTKKGKGFAPAEADPITYHAIGKINAASGGKTPPKYSDVFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGVEIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCVVNMRFVKPLDEQMIRDLAEHTHLFVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFLHQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
B0VQB8
C4JUN6
CYNS_UNCRE
Cyanate lyase
Uncinocarpus
MANLATLDHPYLPQSASLLFDAKAKANLTFEDIARHIGRNEVATAAIFYGQAKASKEDVVKLAELLRLPAQALEMQMGGFPDRGRSVDMPPREPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTNVEKETDDDGNNWAVITLRGKW
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
C4JUN6
D4D449
DMAW_TRIVH
L-tryptophan dimethylallyl transferase
Trichophyton
MGSIEIPNCSGSIVYKTISDFIDFPDHEQKLWWHSTAPMFAEMLRVAGYDLHSQYKILGIFLNHVIPFLGVYPTRINNRWLSILTRYGTPFELSLNCSQSLVRYTYEPINSATGTVKDPFNTHSIWDALDRLMPLQKGIDLEFFKHLKQDLTVDDQDSAYLLENNLVGGQIRTQNKLALDLKGGNFVLKTYIYPALKALATGKSIKTLMFDSVYRLCRQNPSLEAPLRALEEYVDSKGPNSTASPRLLSCDLIDPSKSRVKIYILELNVTLEAMEDLWTMGGRLNDASTLAGLEMLRELWDLIKLPPGMREYPEPFLQLGTIPDEQLPLMANYTLHHDQAMPEPQVYFTTFGLNDGRVADGLVTFFERRGWNHMA
Tryptophan dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid . DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan . The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine . The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde . Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae . However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet .
D4D449
Q8NSN2
METN_CORGL
Methionine import ATP-binding protein MetN
Corynebacterium
MSHTASTPTPEEYSAQQPSTQGTRVEFRGITKVFSNNKSAKTTALDNVTLTVEPGEVIGIIGYSGAGKSTLVRLINGLDSPTSGSLLLNGTDIVGMPESKLRKLRSNIGMIFQQFNLFQSRTAAGNVEYPLEVAKMDKAARKARVQEMLEFVGLGDKGKNYPEQLSGGQKQRVGIARALATNPTLLLADEATSALDPETTHEVLELLRKVNRELGITIVVITHEMEVVRSIADKVAVMESGKVVEYGSVYEVFSNPQTQVAQKFVATALRNTPDQVESEDLLSHEGRLFTIDLTETSGFFAATARAAEQGAFVNIVHGGVTTLQRQSFGKMTVRLTGNTAAIEEFYQTLTKTTTIKEITR
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q8NSN2
P11353
HEM6_YEAST
Oxygen-dependent coproporphyrinogen-III oxidase
Saccharomyces
MPAPQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWVK
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
P11353
Q94361
GEI17_CAEEL
Gex-3-interacting protein 17
Caenorhabditis
MLPNNQWQIPINNGLTHQENMAAHAAVMKLRVHDLQSIISQLSLRKPRPQKSEHQKVVVESLRDPHHARQIYQMASNFPNGNYEMQKRPATTSQVRSHPYVLPSRSGASNHLVNHHYQQQQQQQPQPHNLLHQQMMASHHSHLQQQHHPSTVRWLTPELLEEQLRGSMRYGAPAAAAATNAPLHSSFPNHGRSSQQSLQKSEKSNRPKKMYADNFEPLPLPFYDVISVLLKPVELHSSDSPTLKQTKQLQFPFLLTAEHISKISYRADVTPLPRYELQLRFFNLTEPVQGPQKDDFPLNCYARVDDSVVQLPNVIPTNKTNAEPKRPSRPVNITSNMNRYKKEHTVAVEWLADKRVWAAGVYFVHRVNSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMPVGSSPSGMASTQMGMNEGASKTIRDALNKIGEQSANSSTQSSPLVQLHHTTHPLNFAQSSYMNPSSGSQTPTSQYGYSPMINQAPHFQMQNGLIGRNNQMVHMQQHHLQQQQQQQQSPQIMSPSFYAQQQMSNGGAFAYYPPQYPQQQYRQN
Functions as an E3-type smo-1 ligase . Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment . In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation . In embryos, plays a role in determining telomere localization in the nucleus .
Q94361
A6X0B4
RS7_BRUA4
30S ribosomal protein S7
Brucella
MSRRHKAEKREINPDPKFGDLVITKFMNAVMLHGKKSVAESIVYGALDVIEAKAKSEPVALFHQALDNVAPHIEVRSRRVGGATYQVPVDVRPERRQALAIRWLINAARGRNETTMIDRLSGELLDAANNRGSAVKKREDTHRMAEANRAFSHYRW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
A6X0B4
Q8DEK2
RSMH_VIBVU
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Vibrio
MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFSGMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHARRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRLSVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Q8DEK2
Q4UMK4
PTH_RICFE
Peptidyl-tRNA hydrolase
spotted fever group
MILVIGLGNPGKEYQYTRHNIGFIAIEKIANQYNSSFSIKKKFNCEIAETISDGQKIIFIKPTTYMNLSGKSVISVKTYYNIQSAKIFVIHDDIDLETGRIKFKTGGGNGGHNGLKSIDGVIGNNYNRIRVGVGRPQNNQDVADYVLNNFLKSEYETALQAIDRIANNFDLILENKLEEFKNKIV
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Q4UMK4
Q9N0C8
FBX27_MACFA
F-box only protein 27
Macaca
MGAWASRGRAARVPAPEPESEPEEALDLSQLPPELLLVVLSHVPPRTLLGRCRQVCRGWRALVDGQALWLLILARDHSATGRALLHLARSCQSPARNARPCPLGRFCARRPIGRNPCGQGLRKWMVQHGGDGWVVEENRTTVPGAPSQTCFVTSFSWCRKKQVLDLEEEGLWPELLDSGRIEICVSDWWGARHDSGCMYRLLVQLLDANQTVLDKFSAVPDPIPQWNNNACLHVTHVFSNIKMGVRFVSFEHWGQDTQFWAGHYGARVTNSSVIVRVHLS
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides.
Q9N0C8
B8G6P6
TRUA_CHLAD
tRNA-uridine isomerase I
Chloroflexus
MRTIALLLAYDGTDFAGSQWQTDIRTVQGAIEAAWEALTQEQRRIVLAGRTDAGVHASGQVAHVQTATRHSLATIWRGLNAHLPTDVTVQNVGEAVRDFHARYSAIEREYRYLIDCAPVPLPQLRHQALHYAGTLDVTAMATALKLLEGTHDFAAFTTATPSQRSTVRTMYWTRIVERVWFDRRLLAIELAANAFLQHMVRMIVGTLLLVGRGRMTVDQFGEVLAGRDRRLAGPTAPAHGLTLTAVRYPPGLIRWVEPLERQQGATKVEQPSSYVHEE
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
B8G6P6
C5BQG6
FABZ_TERTT
Beta-hydroxyacyl-ACP dehydratase
Teredinibacter
MLDILEIRKYLPHRYPFLMIDRVVELIEGESITAYKNVSINEEIFQGHFPHFPVFPGVLLIEAMAQACGVLGFKTANKTPEDGSIYLFAGIDGVRFKRQVVPGDRVYFECKVVSAKRGIWKFDCVAKVDGELVTSATIMCADRVVG
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
C5BQG6
Q46IT1
RS11_PROMT
30S ribosomal protein S11
Prochlorococcus
MATTSKKSGSKKSKRNVPNGVVHIQSTFNNTIVSITDTSGEVISWSSAGASGFKGARKGTPFAAQTAAELAARRALEQGMRQIEVLVRGPGSGRETAIRALQVAGLEITLIRDVTPLPHNGCRRPKRRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q46IT1
B4TWF9
MURA_SALSV
UDP-N-acetylglucosamine enolpyruvyl transferase
Salmonella
MDKFRVQGPTTLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDASQVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHITGLEQLGATIKLEEGYVKASVEGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLVTLGAKIAGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKILCRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAQGTGFITETVFENRFMHVPELSRMGARAEIESNTVICHGVETLSGAQVMATDLRASASLVLAGCIAEGTTIVDRIYHIDRGYERIEDKLRALGANIERVKGE
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
B4TWF9
Q8DTM9
WHIA_STRMU
Probable cell division protein WhiA
Streptococcus
MSFTTQVKEEILNLDSADKNELSAIIKMSGSLGLADKKLSLSIITENAKIARHIYALLERLYRINPEIKYHHKTNLRKNRVYTVFLDDNVEQILADLQLSDSFFGIETGIEQQILSDDNAGRSYLKGAFLSTGSIRDPESGKYQLEIFSVYLDHAEDLAKLMQKFMLDTKVIEHKHGAVTYLQKAEDIMDFLIIIGSMEGMEAFENIKVMRETRNDVNRTSNAETANIAKTINASIKTINNINKIKETVGLESLPIELQRIAQIRAAHPDFSIQQIADSLAVPLTKSGVNHRLRKINKIAEDL
Involved in cell division and chromosome segregation.
Q8DTM9
Q84JK2
FD_ARATH
bZIP transcription factor 14
Arabidopsis
MLSSAKHQRNHRLSATNKNQTLTKVSSISSSSPSSSSSSSSTSSSSPLPSQDSQAQKRSLVTMEEVWNDINLASIHHLNRHSPHPQHNHEPRFRGQNHHNQNPNSIFQDFLKGSLNQEPAPTSQTTGSAPNGDSTTVTVLYSSPFPPPATVLSLNSGAGFEFLDNQDPLVTSNSNLHTHHHLSNAHAFNTSFEALVPSSSFGKKRGQDSNEGSGNRRHKRMIKNRESAARSRARKQAYTNELELEVAHLQAENARLKRQQDQLKMAAAIQQPKKNTLQRSSTAPF
Transcription factor required for the transition to flowering promoted by FT.
Q84JK2
Q9SNC0
MBD5_ARATH
Methyl-CpG-binding protein MBD5
Arabidopsis
MSNGTDQAQPPPENPATPVDSKSRKRATPGDDNWLPPDWRTEIRVRTSGTKAGTVDKFYYEPITGRKFRSKNEVLYYLEHGTPKKKSVKTAENGDSHSEHSEGRGSARRQTKSNKKVTEPPPKPLNFDFLNVPEKVTWTGINGSEEAWLPFIGDYKIQESVSQDWDRVFTLVTSQNAGKTMF
Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.
Q9SNC0
B3E4X8
MURA_TRIL1
UDP-N-acetylglucosamine enolpyruvyl transferase
Trichlorobacter
MDKLIINGGRKLKGEVTVSGSKNASLPICIAAVLAPGASTITNVPRLRDITTTAKLLESLGATIERHENTMRIDAGTINTVEATYDLVKTMRASVLVLGPLLARFGRSRVSLPGGCAIGARPIDQHLKGLKALGAEIRLEHGYVEAIAKKGLKGARINFDVSTVGGTEHLMMAAAIAKGESILENAAREPEIADLADYLNRMGAKVEGAGTDTIRIQGVSELTPAAYEVMPDRIEAGTFMCAAAITGGDIKINGMKLEHLDALTFKLMDAGVEITNRNGVVRVKGPKRPQAVNIKTRPYPGFATDMQAQFMALMCVAEGASVISENIFENRFMHVSELLRFGADITVEGNSATVKGVKKLSGAPVMATDLRASACLVLAGLAAEGTTEIQRIYHLDRGYEQIETKLAGLGADIQRVSEP
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
B3E4X8