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During the development phase, participants will undergo apheresis to collect stem cells for base-editing correction of the mutation. |
During the treatment phase, participants will receive the base-edited cells after chemotherapy with busulfan. Participants will remain in the hospital until their immunity recovers. |
Follow-up visits will continue for 15 years. conditions: Chronic Granulomatous Disease (CGD) conditions: X-Linked Chronic Granulomatous Disease studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: B... |
<|newrecord|> nctId: NCT06325696 id: 10001577 id: 001577-E briefTitle: H01 in Adults With Interstitial Lung Disease (The SOLIS Study) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-22 date: 2024-04-26 name: National Institute of Environmental Health Sciences (NIEHS) c... |
Interstitial lung disease affects the tissues that aid the transfer of oxygen and carbon dioxide between the air and the bloodstream. The disease can cause fibrosis, a thickening and scarring of lung tissue. Fibrosis often continues getting worse, and most people with this disease die in 3 to 5 years. |
Objective: |
To test a study drug (hymecromone) in people with interstitial lung disease or lung fibrosis. |
Eligibility: |
People aged 18 years and older with interstitial lung disease or lung fibrosis. |
Design: |
Participants will have at least 7 clinic visits over 5 months. |
Participants will have screening and baseline visits. They will have blood tests and tests of their heart function. They will give a sputum sample. Other tests will include: |
Spirometry: Participants will breathe in and out through a mouthpiece to measure how much air they can hold in their lungs and how hard they can breathe. |
Diffusion capacity of lungs for carbon monoxide: Participants will breathe in a gas that contains a small amount of carbon monoxide. Then they will breathe through a mouthpiece. This test measures how well oxygen moves from the air into the blood. |
Resting energy expenditure. Participants will lie still for 30 minutes with a clear dome over their head. This test measures the calories their body burns at rest. |
6-minute walk test. Participants will walk at their normal pace for 6 minutes. Their vital signs and blood oxygen levels will be checked. |
Hymecromone is a tablet taken by mouth. Participants will take 2 tablets every morning and 2 tablets every night for 12 weeks. Tests will be repeated at study visits. conditions: Interstitial Lung Disease conditions: Idiopathic Pulmonary Fibrosis conditions: Lung Diseases, Interstitial studyType: INTERVENTIONAL phases:... |
<|newrecord|> nctId: NCT06325683 id: NCI-2024-01995 id: NCI-2024-01995 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: A072201 type: OTHER domain: Alliance for Clinical Trials in Oncology id: A072201 type: OTHER domain: CTEP id: U10CA180821 type: NIH link: https://reporter.nih.gov/quickSearch/U10CA18... |
<|newrecord|> nctId: NCT06325670 id: 23/50374 briefTitle: Type 2 Diabetes and Binge Eating Disorder (BED) overallStatus: RECRUITING date: 2024-02-23 date: 2024-12 date: 2025-06 date: 2024-03-22 date: 2024-03-22 name: Odense University Hospital class: OTHER name: Jascha Fonden name: Independent Research Fund Denmark bri... |
The main questions it aims to answer are: |
* Does treatment for Binge Eating Disorder lead to improvements in BED symptoms? |
* Does treatment for Binge Eating Disorder lead to improvements in T2D severity and associated cardiovascular risk factors? |
Participants will undergo a comprehensive treatment program targeting both BED and T2D. This program will include psychotherapy sessions focusing on cognitive-behavioral techniques to address binge eating behavior. |
Researchers will compare participants' outcomes before and after the treatment program to assess changes in BED symptoms, T2D severity, and associated cardiovascular risk factors. conditions: Diabetes Mellitus, Type 2 conditions: Binge-Eating Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interven... |
<|newrecord|> nctId: NCT06325657 id: C3671032 briefTitle: A Study to Learn About the Vaccine RSVpreF In Pregnant Participants With HIV and Their Infants acronym: MORISOT overallStatus: RECRUITING date: 2024-03-12 date: 2025-06-11 date: 2025-06-11 date: 2024-03-22 date: 2024-04-11 name: Pfizer class: INDUSTRY briefSumma... |
The study will look at the safety, tolerability, and immune activity in mothers and their infants. |
This study is seeking pregnant women who are: |
* Less than or equal to 49 years old and have HIV (Human immunodeficiency virus - |
* Receiving standard medical care during the pregnancy |
* Do not have syphilis (bacterial sexually transmitted disease), Hepatitis B Virus ((HBV) liver infection), Tuberculosis ((TB) bacterial lung infection). |
* Have been on stable (anti-retroviral) HIV treatment for more than or equal to 90 days. |
* agree to be present for all study visits, procedures, and blood draws. |
Participants will either receive: |
* RSVpreF vaccine |
* A placebo. A placebo does not have any medicine it but looks just like the study vaccine. |
Pregnant participants will be involved in the study from: |
* consent during their current pregnancy, and |
* for 6 months after delivery of their baby (around 10 months in total). Pregnant participants will have at least 5 planned visits in this study. Infant participants: All eligible babies born to enrolled mothers will be followed up from birth for up to 6 months. Infant participants will have at least 3 study visits, wi... |
<|newrecord|> nctId: NCT06325644 id: 2023H0258 id: CDMRP-PR212399-G type: OTHER_GRANT domain: Departent of Defense briefTitle: Well-Formulated Ketogenic Diet Polycystic Kidney Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2027-04-01 date: 2024-03-22 date: 2024-03-22 name: Ohio State ... |
<|newrecord|> nctId: NCT06325631 id: Ankara City Hospital Bilkent briefTitle: Comparative Evaluation of the Results of Facet Joint Injections overallStatus: RECRUITING date: 2023-01-02 date: 2024-03-31 date: 2024-04-30 date: 2024-03-22 date: 2024-03-22 name: Oznur Uzun class: OTHER briefSummary: Low back pain affects 6... |
<|newrecord|> nctId: NCT06325618 id: 1-10-72-138-23 briefTitle: Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome acronym: TSCOR_V overallStatus: RECRUITING date: 2024-01-08 date: 2027-08 date: 2027-08 date: 2024-03-22 date: 2024-03-22 name: University of Aarhus class: OTHER name: Aarhus Univers... |
The aim is to examine and quantify the cardiovascular and lymphatic system in women with TS. The investigators will study a possible causal mechanism between the known pathologic phenotype and alterations in these systems to understand, prevent or treat the life-threatening complications in TS. conditions: Turner Syndr... |
<|newrecord|> nctId: NCT06325605 id: GRYY-LL-KJ2022-064 briefTitle: Efficacy and Safety of Bifidobacterium Combined With High-frequency Transcranial Magnetic Stimulation in the Treatment of Adolescent Depression overallStatus: COMPLETED date: 2022-03-01 date: 2022-10-31 date: 2022-10-31 date: 2024-03-22 date: 2024-03-2... |
<|newrecord|> nctId: NCT06325592 id: REHSIL2023V1.1 briefTitle: Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL overallStatus: COMPLETED date: 2023-10-01 date: 2024-03-01 date: 2024-03-01 date: 2024-03-22 date: 2024-03-22 name: Sichuan... |
<|newrecord|> nctId: NCT06325579 id: AA29411356 briefTitle: Immersive Virtual Reality for Dysphagia acronym: IVRys overallStatus: COMPLETED date: 2021-05-24 date: 2023-02-28 date: 2023-03-31 date: 2024-03-22 date: 2024-03-25 name: Sheffield Hallam University class: OTHER briefSummary: People who have suffered a stroke ... |
<|newrecord|> nctId: NCT06325566 id: MSB-DR004 briefTitle: Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain acronym: HyaluronicAcid overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-08 date: 2027-08 date: 2024-03-22 date: 2024-03-22 name: M... |
<|newrecord|> nctId: NCT06325553 id: 022_2566 briefTitle: Incidence of Platelet Refractoriness in Adult Acute Leukemia Patients Receiving Prestorage Filtered Blood and Comparing With Historical Control acronym: PTR overallStatus: RECRUITING date: 2024-03-30 date: 2025-03-30 date: 2026-03-30 date: 2024-03-22 date: 2024-... |
<|newrecord|> nctId: NCT06325540 id: pulpcapping briefTitle: Clinical Success of Indirect Pulp Capping: 1-Year Follow-Up overallStatus: COMPLETED date: 2023-01-01 date: 2024-02-01 date: 2024-02-15 date: 2024-03-22 date: 2024-03-22 name: Saglik Bilimleri Universitesi class: OTHER briefSummary: The goal of this clinical ... |
<|newrecord|> nctId: NCT06325527 id: YuGarden-01 briefTitle: Cognitive Impairment Cohort Study of the Elderly Population in YuGarden overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2031-04-01 date: 2031-06-01 date: 2024-03-22 date: 2024-03-22 name: Ruijin Hospital class: OTHER briefSummary: The goal of this pr... |
The main questions it aims to answer are: |
* incidence of cognitive impairment in community (converting to mild cognitive impairment or Alzheimer's disease) |
* to build a predictive model for the progression of cognitive impairment conditions: Alzheimer Disease conditions: Neurodegenerative Diseases conditions: Cognitive Impairment conditions: Mild Cognitive Impairment studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1872 type: ESTIMAT... |
<|newrecord|> nctId: NCT06325514 id: NA2024 briefTitle: Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-01 date: 2024-09-01 date: 2024-03-22 date: 2024-03-26 name: Cairo University class: OTHER brief... |
<|newrecord|> nctId: NCT06325501 id: AA-2024-1 briefTitle: Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy overallStatus: RECRUITING date: 2024-03-01 date: 2024-12-01 date: 2025-01-01 date: 2024-03-22 date: 2024-03-22 name: Cairo University class: OTHER briefSummary: Uterine leio... |
Various interventions have been introduced to reduce bleeding during myomectomy, such as tourniquets, bupivacaine plus epinephrine infiltration, vasopressin injection, preoperative GnRH agonist administration, and preoperative ascorbic acid injection. However, these strategies may have complications, be ineffective, ex... |
Oxytocin, primarily secreted from the pituitary gland, is crucial for uterine contraction during labor and delivery, and is used to prevent postpartum uterine atony and bleeding. However, caution is needed in its use, especially in women with heart disease or hypovolemia. |
Misoprostol, a prostaglandin E1 analogue, can reduce bleeding during myomectomy by promoting myometrial contractions and reducing uterine artery blood flow. It can be administered via multiple routes, with rectal administration showing advantages in maintaining high plasma concentrations during surgery. Studies have in... |
<|newrecord|> nctId: NCT06325488 id: H-23035668 briefTitle: Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease acronym: FORTIFY overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-01 date: 2025-06-01 date: 2024-03-22 date: 2024-03-22 name: Caroline Michaela Kistorp class: OTHER name: Sano... |
The study will achieve this by: |
1) Using a non-invasive, contrast-free MRI protocol focusing on parameters of oxygenation, inflammation, fibrosis, and injury in the kidney. |
2) Using an extensive, in-depth biomarker blood panel to investigate the pathological pathways associated with Fabry disease and Fabry-associated nephropathy. conditions: Fabry Disease conditions: Chronic Kidney Diseases studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 ty... |
<|newrecord|> nctId: NCT06325475 id: B.30.2.ATA.0.01.00/530 briefTitle: Comparison of Patients' Postpartum Recovery Using ObsQoR-10 Score in Pregnant Women in Vaginal Delivery With and Without Neuraxial Labor Analgesia overallStatus: RECRUITING date: 2024-03-26 date: 2024-07-26 date: 2024-08-26 date: 2024-03-22 date: 2... |
<|newrecord|> nctId: NCT06325462 id: E2232/2023 briefTitle: The Influence of Anesthetic Technique on Cerebral Oxygenation During Spinal Surgery overallStatus: RECRUITING date: 2024-02-10 date: 2024-08 date: 2024-12 date: 2024-03-22 date: 2024-03-22 name: Prince Sultan Military Medical City class: OTHER briefSummary: Po... |
<|newrecord|> nctId: NCT06325449 id: 5323 briefTitle: Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity acronym: FLOWERS-PCOS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-01-01 date: 2026-01-01 date: 2024-03-22 date: 2024-03-22 name: Otta... |
Participants will complete a 24-week weight loss program (STREAM). During this program they will: |
* weigh themselves |
* complete regular bloodwork and |
* fill out a Quality of Life questionnaire at regular intervals conditions: Polycystic Ovary Syndrome conditions: Obesity studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Clinic patients with PCOS will be recruited to participate in a 24-week weight loss ... |
<|newrecord|> nctId: NCT06325436 id: scores in variceal bleeding briefTitle: Objective Scores in Variceal Bleeding overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-05-01 date: 2026-01-01 date: 2024-03-22 date: 2024-03-22 name: Assiut University class: OTHER briefSummary: To assess the prognostic performance o... |
<|newrecord|> nctId: NCT06325423 id: response to NAC in MIBC briefTitle: Predicting Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-06 date: 2027-06 date: 2024-03-22 date: 2024-03-26 name: Assiut University class: OTHER briefSummary: Blad... |
The mainstay of treatment of muscle-invasive BC( MIBC) is neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) or bladder preservation(BP) using maximal transurethral resection of the bladder tumor followed by chemoradiation. The rationale to use NAC before RC or BP is to eradicate micro-metastasis and to... |
The 5-year cancer-specific survival for responders to NAC is 90%, in contrast to 30-40% for those not obtaining an objective response. Drawbacks of NAC are disappointing delay of surgery in non-responders and the potential toxicity. So, predictors of response to NAC are necessary to identify patients who may achieve pa... |
Tumor microenvironment (TME), including neutrophil extracellular traps (NETs), and CD8+ T lymphocytes is a promising predictor of response to NAC in MIBC. |
NETs are reticulated DNA structures decorated with various protein substances (e.g., histones, myeloperoxidase, neutrophil elastase).NETs are involved in tumor growth, metastasis, and treatment resistance. Moreover, NETs can inhibit T cell responses, thereby promoting tumor growth. |
On the other hand, immune cells that are present in the TME play a major role in slowing down tumor progression. CD8+T lymphocytes play a central role in immune-mediated control of cancer . Also, they have been found to be a prognostic tool for advanced BC. conditions: Muscle-Invasive Bladder Carcinoma studyType: OBSER... |
<|newrecord|> nctId: NCT06325410 id: #11279-20-11-2023 briefTitle: Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience overallStatus: COMPLETED date: 2013-01 date: 2022-12 date: 2022-12 date: 2024-03-22 date: 2024-03-22 name: Zagazig Univer... |
Data was collected from records in a retrospective cohort study conditions: Colorectal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 200 type: ACTUAL name: resection of colorectal cancer measure: age measure: sex measure: medical disease measure: previous surgery measu... |
<|newrecord|> nctId: NCT06325397 id: IIT #88313865 briefTitle: Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP) overallStatus: RECRUITING date: 2023-10-23 date: 2024-04 date: 2024-06 date: 2024-03-22 date: 2024-03-22 name: Matthew Rauen class: OTHER briefSummary: To inve... |
<|newrecord|> nctId: NCT06325384 id: IRAS ID:1008701 briefTitle: Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care acronym: VISION-RWE overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-08-31 date: 2025-08-31 date:... |
<|newrecord|> nctId: NCT06325371 id: 0028201 briefTitle: Italian Multicentric Study on the Treatment of Visceral Aneurysms With the Flow Diversion Stent Derivo Peripher and Derivo 2 acronym: DEDICATE overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-06-30 date: 2025-06-30 date: 2024-03-22 date: 2024-03-22 n... |
The enrollment period will be of 54 months (01/01/2020-30/06/2024). Minimum sample size will be of 50 Patients. conditions: Aneurysm Abdominal conditions: Arterial Aneurysm studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 50 type: ESTIMATED name: Visceral aneurysm stenting mea... |
<|newrecord|> nctId: NCT06325358 id: 0040083/23 briefTitle: the EXPOSITION Study acronym: EXPOSITION overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-30 date: 2024-12-30 date: 2024-03-22 date: 2024-03-22 name: University of Pavia class: OTHER name: National Research Council (Consiglio Nazionale delle Ri... |
<|newrecord|> nctId: NCT06325345 id: 22-5277 briefTitle: RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-29 date: 2025-04-01 date: 2024-03-22 date: 2024-03-22 name: University Health Network, To... |
1. Is gut-directed hypnotherapy an efficacious treatment for IBS symptoms among individuals with EDS or G-HSD? |
2. Does gut-directed hypnotherapy improve other gut symptoms, quality of life, visceral sensitivity, and emotional distress? |
3. Is the activity of the parasympathetic nervous system (i.e. the body's "rest and digest" system) associated with IBS symptoms or treatment outcomes among individuals with EDS or G-HSD? |
All participants will be asked to meet with a gastroenterologist three times as part of the standard medical therapy. At each physician visit, they will undergo electrocardiogram recording and complete self-report measures of gastrointestinal symptoms, quality of life, visceral sensitivity, and emotional distress. Part... |
Researchers will compare study groups to see if participants who engaged in gut-directed hypnotherapy had greater improvement in IBS symptoms, other gastrointestinal symptoms, quality of life, visceral sensitivity, and emotional distress. Exploratory analyses will examine the relationships among heart rate variability,... |
<|newrecord|> nctId: NCT06325332 id: RSV00080 briefTitle: BEYFORTUS™ (Nirsevimab) Effectiveness Against Medically-Attended RSV Events in Infants (BEAR Study) acronym: BEAR overallStatus: RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-03-22 date: 2024-04-08 name: Sanofi Pasteur, a Sanofi Compan... |
the secondary objectives are: |
1. To estimate the effectiveness of nirsevimab against medical encounters with a respiratory related diagnosis. |
2. To estimate the effectiveness of nirsevimab against medical encounters with an LRTD diagnosis. |
3. To estimate the impact of nirsevimab on PCR-confirmed RSV. |
4. To estimate the impact of nirsevimab on medical encounters with an otitis media diagnosis. |
5. To estimate the impact of nirsevimab on antibiotic prescription. conditions: Respiratory Syncytial Virus studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 33000 type: ESTIMATED name: Nirsevimab measure: Incidence of first episodes of polymerase chain reaction (PCR)-confirmed R... |
<|newrecord|> nctId: NCT06325319 id: Ref. No. MA.84/261/02/1/115 briefTitle: Effect of Community Engagement Using M-Mama Champions overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-04 date: 2024-05 date: 2024-03-22 date: 2024-03-22 name: University of Dodoma class: OTHER name: Stephen Kibusi name: James Tumain... |
The following is the hypothesis being tested |
Null Hypothesis; There is no difference in improvement of awareness of Obstetric Danger Signs, Birth Preparedness, and Complication Readiness among Pregnant Women when community engagement is done using M-MAMA Champions compared to routine approaches. |
Alternative hypothesis; Community engagement using M-MAMA Champions to improve awareness of Obstetric Danger Signs, Birth Preparedness, and Complication Readiness among Pregnant Women is more effective than routine approaches. |
During each 2-hour session, five (5) women will gather up and discuss the obstetric danger signs, birth preparedness, and complication readiness with the assistance of the M-MAMA Champion as a facilitator. An approved brochure on the concerned subject will be used for sensitization. Baseline data will be collected befo... |
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