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* Aim 1. Compare the relationship between the blood and the gut microbiomes among a sample of (1) pre-WLS and (2) 6-month post-WLS participants. |
Hypothesis: Blood bacterial composition will resemble that of the gut microbiome among pre-WLS participants. Because the effect of WLS on the blood microbiome is not known, our post-WLS results will be mostly exploratory. |
* Aim 2. Determine racial differences in the blood microbiome of the pre- and post-WLS groups. |
Hypothesis2: Ethnic differences will be detected in both the pre- and post-WLS groups. conditions: Obesity conditions: Metabolic Syndrome studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 100 type: ESTIMATED measure: Gut Microbial Composition measure: Blood Microbial Composition... |
<|newrecord|> nctId: NCT06342037 id: N22TON briefTitle: NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial acronym: TONIC-3 overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2026-04-01 date: 2030-04-01 date: 2024-04-02 date: 2024-04-18 name: The Netherlands C... |
<|newrecord|> nctId: NCT06342024 id: 23-871 briefTitle: Pistachio Consumption on Inflammatory Markers and Lean Body Mass overallStatus: RECRUITING date: 2024-02-20 date: 2025-05-30 date: 2025-08-31 date: 2024-04-02 date: 2024-04-02 name: Virginia Polytechnic Institute and State University class: OTHER briefSummary: Pis... |
The purpose of this study will be to determine the effects of consuming 1.5 ounces of pistachios per day compared to consuming no pistachios per day on inflammatory markers (creatine kinase, C-reactive protein, cortisol, Interleukin-8, tumor necrosis factor-alpha, copper-zinc superoxide dismutase, and glutathione perox... |
This will be a randomized study where participants will first complete a two-week baseline run-in period during which they will consume their typical diet. Following this, participants will be randomized to one of two groups for six months: consuming 1.5 ounces of pistachios per day or a control group (consuming no pis... |
The overall goal of this study is to evaluate the effects of pistachio consumption on inflammatory markers and lean body mass in women and men, 40 to 60 years of age, who exercise three to five days per week. This study could provide a simple, healthy way for recreationally active individuals to decrease inflammation a... |
<|newrecord|> nctId: NCT06342011 id: KY-2024-039 briefTitle: Effect of Anti-inflammatory Diet in Patients With Inflammatory Bowel Disease overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-12-31 date: 2024-04-02 date: 2024-04-02 name: The Fourth Affiliated Hospital of Zhejiang University Sch... |
<|newrecord|> nctId: NCT06341998 id: HERO2020 briefTitle: Clinical Study of Chemotherapy in the Treatment of Recurrent/Refractory Yolk Sac Tumor in Children acronym: SCRRYST overallStatus: COMPLETED date: 2020-06-01 date: 2024-01-01 date: 2024-02-01 date: 2024-04-02 date: 2024-04-02 name: Shandong First Medical Univers... |
<|newrecord|> nctId: NCT06341985 id: IEO 1593 briefTitle: DOsimetry and Radiation Induced NAusea in Head and Neck Cancers acronym: DORIAN overallStatus: RECRUITING date: 2021-11-15 date: 2024-11-15 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: European Institute of Oncology class: OTHER briefSummary: This is... |
The primary purpose of this study is to search for a potential correlation between dosimetry and physician- and patient-rated symptoms in patients treated with exclusive radiotherapy for head and neck cancer. conditions: Head and Neck Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTI... |
<|newrecord|> nctId: NCT06341972 id: IRB00247005 id: K23HL155735 type: NIH link: https://reporter.nih.gov/quickSearch/K23HL155735 briefTitle: Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention acronym: SMARA overallStatus: NOT_YET_RECRUITING date: 2024-06-15 da... |
The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and potential benefit of an evidence-based psychological intervention for anxiety and associated outcomes for ICU patients. |
The main question\[s\] it aims to answer are: |
* Is this intervention feasible and acceptable in ARF patients? |
* Is this intervention in the ICU and hospital associated with reduced anxiety symptoms? |
Participants will participate in a cognitive behavioral therapy informed self-management intervention aimed to reduce anxiety symptoms. Researchers will compare the intervention group to patients who receive usual care to see if the intervention reduces symptoms at the the conclusion of the intervention and at 3 months... |
<|newrecord|> nctId: NCT06341959 id: GerodentPLUS1 briefTitle: Can a Low-threshold Check-up Motivate Older People to Schedule a Dental Visit? overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-30 date: 2024-12-30 date: 2024-04-02 date: 2024-04-26 name: University Ghent class: OTHER briefSummary: There is ... |
In the control group, no oral examination will be performed. However, participants will be given a list of nearby dentists and flyers with oral hygiene instructions. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 194 type: ESTIMATED name: Oral screening measure: Contacted a... |
<|newrecord|> nctId: NCT06341946 id: Soh-Med-24-02-05MD briefTitle: Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2025-10-01 date: 2025-11 date: 2024-04-02 date: 2024-04-02 name: Sohag University class: OTHER ... |
<|newrecord|> nctId: NCT06341933 id: 2024-BÇEK/41 briefTitle: Risk Factors for AKI in Patients Undergoing VATS for Pulmonary Resection overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-15 date: 2025-04-15 date: 2024-04-02 date: 2024-04-02 name: Atatürk Chest Diseases and Chest Surgery Training and Resear... |
The research will be conducted at SBÜ Ankara Atatürk Sanatorium Training and Research Hospital. The study will involve patients who have given informed consent and will undergo VATS with standard anaesthesia monitoring. Anaesthesia management will follow our routine protocol in our clinic. |
Patients will be divided into two groups based on whether they have a more than 25% decrease in estimated glomerular filtration rate (t-GFH) and/or a 1.5-fold increase in serum creatinine and/or a 6-hour urine volume of less than 0.5 ml/kg/h. The patients will be divided into two groups based on this definition, and th... |
The preoperative routine blood values, demographic data (age, gender, height, weight, and BMI), ASA physical status, smoking and alcohol habits, comorbidities, and regular medication use will be recorded. Intraoperative urine output and haemodynamic parameters will also be monitored. Routine blood gas analysis, blood u... |
<|newrecord|> nctId: NCT06341920 id: RS198 - 332551 briefTitle: BoneFit: Multimodal Prehabilitation for People Preparing for Orthopaedic Surgery acronym: BoneFit overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-07-01 date: 2027-12-01 date: 2024-04-02 date: 2024-04-02 name: University of Hull class: OTHER n... |
<|newrecord|> nctId: NCT06341907 id: SAHoWMU-CR2024-07-107 briefTitle: Application of MRD Combined With Personalized Vaccine in the Treatment of Postoperative Recurrence Prevention of EOC overallStatus: RECRUITING date: 2024-01-01 date: 2026-12-31 date: 2026-12-31 date: 2024-04-02 date: 2024-04-02 name: Second Affiliat... |
<|newrecord|> nctId: NCT06341894 id: OBU-II-BC-126 briefTitle: Efficacy and Safety of Dalpiciclib With Endocrine Therapy as Adjuvant Treatment in HR+/ HER2- Early Breast Cancer overallStatus: RECRUITING date: 2023-11-17 date: 2027-06 date: 2029-06 date: 2024-04-02 date: 2024-04-02 name: The First Affiliated Hospital wi... |
<|newrecord|> nctId: NCT06341881 id: KMU/DIR/CTU/2024/006 id: KMU-CTU-2024-2001 type: OTHER domain: Khyber Medical University Clinical Trial Unit briefTitle: Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan overallStatus: RECR... |
<|newrecord|> nctId: NCT06341868 id: KACH.2023.0067 id: 23KACH008 type: OTHER domain: Keller Army Community Hospital briefTitle: Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-0... |
* Examine the effects of KneeStim wear on cadets' post-operative gait |
* Examine changes in site-specific skeletal muscle mass |
* Examine the changes in patient-reported outcomes |
* Assess time to return to full duty |
* Compare Bioelectrical Impedance Analysis (BIA) measurements to Magnetic Resonance Imaging (MRI) measurements (total thigh volume) |
* Determine the concurrent criterion validity of the KneeStim device compared to gold- standard metrics (3D Motion Capture) |
Participants will undergo body composition analysis, MRI, strength testing, standard of care rehabilitation, gait analysis, and complete surveys. Participants will wear the KneeStim during their standard of care rehabilitation visits for the first 5 weeks post-operative, and throughout daily tasks from 6-12 weeks. |
Researchers will compare a control group (standard of care + KneeStim controlled low intensity) to an experimental group (standard of care + KneeStim flexible intensity) to assess the aims previously mentioned.. conditions: Anterior Cruciate Ligament Injuries studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED ... |
<|newrecord|> nctId: NCT06341855 id: 23K294001 briefTitle: Exploring the Potential of ctDNA-MRD for Recurrence Surveillance and Prognostic Evaluation in High-risk Endometrial Cancer overallStatus: RECRUITING date: 2024-01-25 date: 2026-01-30 date: 2026-01-30 date: 2024-04-02 date: 2024-04-02 name: The First Hospital of... |
<|newrecord|> nctId: NCT06341842 id: EudraCT 2022-003377-28 briefTitle: Potential Protective Role of SGLT-2 Inhibitors for Chemotherapy-induced Cardiotoxicity acronym: PROTECT overallStatus: RECRUITING date: 2023-10-19 date: 2025-04-19 date: 2025-04-19 date: 2024-04-02 date: 2024-04-02 name: Fondazione IRCCS Policlinic... |
<|newrecord|> nctId: NCT06341829 id: PRISM1 briefTitle: Visuospatial and Affective Abilities in Parkinson Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-17 date: 2024-04-18 date: 2026-02-28 date: 2024-04-02 date: 2024-04-16 name: IRCCS Centro Neurolesi "Bonino-Pulejo" class: OTHER briefSummary: The aim of the ... |
<|newrecord|> nctId: NCT06341816 id: VEXUS2 briefTitle: Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-10-01 date: 2024-12-01 date: 2024-04-02 date: 2024-04-23 name: Inonu University class: OTHER briefSummary: Heart fail... |
Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker whose values in both urine and plasma have been associated with acute kidney injury (AKI). Although NGAL is an early specific biomarker for AKI, it has not yet come into routine use, but is frequently used in clinical and experimental studies (4). |
Venous load ultrasonography score (VExUS) is a new systemic congestion scoring method based on inferior vena cava dilation and pulsed wave Doppler (PW-Doppler) morphology of the hepatic, portal and renal veins. It has been proposed as a score to assess systemic congestion. conditions: Heart Failure conditions: Acute Ki... |
<|newrecord|> nctId: NCT06341803 id: DSRB 2023/00397 briefTitle: Personalized Transcranial Magnetic Stimulation Treatment for Depression acronym: APIC-TMS overallStatus: RECRUITING date: 2024-03-01 date: 2025-04-01 date: 2025-12-31 date: 2024-04-02 date: 2024-04-02 name: Institute of Mental Health, Singapore class: OTH... |
Participants will be patients with Major Depressive Disorder not responding to standard treatment, with no exclusions to fMRI or transcranial magnetic stimulation (TMS) (essentially metal implants in the head) and willing to participate in the pilot. |
All participants will undergo MRI scans before and after the accelerated TMS treatment. The multi-session hierarchical Bayesian model (MS-HBM) approach will be used to estimate individualized connectome-guided target locations. |
Patients will undergo accelerated TMS applied to individualized connectome-guided target locations (based on the MS-HBM approach). |
Patients will undergo 10 sessions (each session lasting 10 min) spread out over 10 hours each day for 5 consecutive working days. |
All clinical outcome data will be collected for each patient by a pre-defined questionnaire at four time points: at baseline, post-treatment, 1 month and 3 months during follow-up. |
The clinical outcome data will be analyzed using linear regression or repeated analysis of variance (ANOVA) after adjusting for baseline clinical characteristics and socio-demographics. Trajectories of the clinical outcome data at baseline, post-treatment and all follow-up time points will be plotted and compared with ... |
<|newrecord|> nctId: NCT06341790 id: NAFLD-02 briefTitle: Effect of Consumption of Millet Diet in Patients With NAFLD overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2026-07-05 date: 2026-07-05 date: 2024-04-02 date: 2024-04-02 name: Institute of Liver and Biliary Sciences, India class: OTHER briefSummary: Wit... |
It is apparent that the westernized way of our lifestyle especially the junk food culture comprising of super portions of loads of calories, sugars and salts is the main driver of this nutritional pandemic. The traditional diets in India were rich in fruits and vegetables, low in simple carbohydrates and high in fibre.... |
Gut microbiota is currently explored for its role in NAFLD and there are gaps in knowledge which preclude having therapeutic strategies through its modulation. Millets, which were once considered to be poor man's diet are now becoming a part of the plate more frequently, especially for its unique nutritive content, wit... |
<|newrecord|> nctId: NCT06341777 id: 25M621 briefTitle: Multisensory Telerehabilitation for Visual Field Defects acronym: MUST overallStatus: COMPLETED date: 2020-01-01 date: 2023-12-31 date: 2023-12-31 date: 2024-04-02 date: 2024-04-02 name: Istituto Auxologico Italiano class: OTHER name: IRCCS Fondazione Stella Maris... |
<|newrecord|> nctId: NCT06341764 id: CITATION id: 7/23 type: OTHER domain: IRCCS I.N.T. "G. Pascale" briefTitle: Neo-adjuvant Chemo and Immunotherapy in The Pre-operAtive Treatment of Locally Advanced cholangIOcarciNoma overallStatus: RECRUITING date: 2023-09-01 date: 2024-09 date: 2025-09 date: 2024-04-02 date: 2024-0... |
<|newrecord|> nctId: NCT06341751 id: 2024-00393-01 briefTitle: Psychological Treatment for Persistent Fatigue overallStatus: RECRUITING date: 2024-04-11 date: 2024-12 date: 2025-04 date: 2024-04-02 date: 2024-04-12 name: Karolinska Institutet class: OTHER name: Forte name: The Swedish Research Council name: Region Stoc... |
<|newrecord|> nctId: NCT06341738 id: 421/215/404.102.28/VI/2023 briefTitle: The Efficacy of Digital Educational Interventions on Parental HPV Knowledge and Attitude, and Their Children's Vaccination Rates overallStatus: COMPLETED date: 2023-07-05 date: 2024-02-01 date: 2024-02-29 date: 2024-04-02 date: 2024-04-02 name:... |
* Is the digital educational intervention in improving parent's HPV knowledge in the intervention group compared to the control group? |
* Is the digital educational intervention in improving parent's attitude toward HPV vaccine in the intervention group compared to the control group? |
* Is the digital educational intervention more effective in increasing children's HPV vaccine completion rates in the intervention group compared to the control group? |
Participants in intervention group will: |
* watch a 8 minutes video in front of class at once. |
* after video education intervention, in 2 weeks, participants received 2 reminder messages before first and second vaccination event, respectively. |
Participants in control group will: |
• Receive usual announcement regarding vaccine by staff conditions: Health Services Research studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: 10 units are divided into 2 arms (e.g. intervention and control) by cluster randomisation using the number of... |
<|newrecord|> nctId: NCT06341725 id: LinfoK EUS 2016 briefTitle: EUS Role in Non-metastatic Pancreatic Adenocarcinoma Lymph Nodes Staging overallStatus: TERMINATED date: 2018-02-15 date: 2018-02-15 date: 2018-09-11 date: 2024-04-02 date: 2024-04-02 name: Paolo Giorgio Arcidiacono, MD class: OTHER briefSummary: Aim of t... |
* in RESECTABLE pancreatic cancer the investigators will evaluate the concordance with EUS elastography and histological findings of lymph nodes obtained during surgery, in order to assess the sensibility, specificity and the positive and negative predictive value of EUS with elastography, the disease-free survival, th... |
* in "BORDERLINE resectable" and UNRESECTABLE non-metastatic ("advanced" locally") disease, the investigators will evaluate if the malignant lymph nodes samples during EUS with elastography and fine needle aspiration (FNA) will be related to a decreased survival. |
Secondary aim will be to register the prognosis (in terms of survival) of the patients with para-aortic and mediastinal pathological lymph nodes (related to a decreases survival in some series in literature) conditions: Pancreatic Adenocarcinoma conditions: Lymph Node Metastasis studyType: OBSERVATIONAL observationalMo... |
<|newrecord|> nctId: NCT06341712 id: CLIN-60000-461 id: 2023-506229-12-00 type: OTHER domain: Ipsen briefTitle: Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma acronym: CabOSTar overallStatus: NOT_YET_RECRUITING date: 2024-06-13 date: 2026-10-26 date: 2028-06-15 date: 2024-04-02... |
Participants will have achieved a partial response or stable disease at the end of conventional chemotherapy. Osteosarcoma is cancer of the bone. The cancer cells make immature bone cells, known as osteoid. |
Osteosarcoma is very rare, but it is the most common type of bone cancer in children and teens. It is most common in teens and young adults. |
In this study, participants will receive either cabozantinib and best supportive care or the best supportive care alone. Best supportive care will be provided at the investigator's discretion and according to institutional guidelines. |
It includes antibiotics, nutritional support, correction of metabolic disorders, optimal symptom control and pain management (including radiotherapy), etc. but does not include tumor specific therapy. |
Cabozantinib will be taken by mouth (orally), as a tablet, once a day. Cabozantinib will be provided to participants who tolerate it for as long as their disease does not progress. Participants in the study receiving best supportive care alone may switch to treatment with cabozantinib and best supportive care if their ... |
Participants may withdraw consent to participate at any time. |
The estimated duration of the study for participants is 24 months, however a participant could remain in the study longer if demonstrating treatment benefit. conditions: Osteosarcoma conditions: Osteosarcoma in Children conditions: Osteosarcoma in Adolescents and Young Adults studyType: INTERVENTIONAL phases: PHASE2 al... |
<|newrecord|> nctId: NCT06341699 id: 05C308 briefTitle: Study of the Steroid Hormone Milieu in Obese Patients acronym: MiSterO overallStatus: RECRUITING date: 2023-05-16 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: Istituto Auxologico Italiano class: OTHER name: Ministry of Health, Italy br... |
It will be also investigated if this hormonal milieu is a predictive factor for cardiovascular disease in obese patients. |
Eligible subjects are male patients (age 18-80 years) with severe obesity and no other known causes of hypercortisolism or hypogonadism. |
Questionnaires for the evaluation of mood and symptoms will be collected upon enrollment, patient's anamnestic and clinical data relating to disease complications, BMI, previous blood tests, cortisol suppression with dexamethasone 1 mg will be collected, and blood sample will be sent to and analyzed at a centralized la... |
<|newrecord|> nctId: NCT06341686 id: 75471023.2.0000.0082 briefTitle: Evaluation of the Prophylactic Use of Letermovir in Kidney Transplant Recipients at Risk of Cytomegalovirus Infection overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2025-03 date: 2025-05 date: 2024-04-02 date: 2024-04-02 name: Hospital do R... |
2. Patients randomized to the preemptive treatment group: Preemptive treatment (PET) will begin on day 21, evaluating CMV DNAnemia weekly until D98.CMV DNAnemia weekly until day 98 (21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 91 and 98). The threshold for starting treatment with Ganciclovir is a CMV DNAemiaDNAemia \> 5,000... |
3. In both groups, CMV DNAemia will be monitored weekly until day 98 (21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 91 and 98), and after any acute rejection treatment occurring between 3 months and 6 months after kidney transplantation. primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 100 type: ESTIMA... |
<|newrecord|> nctId: NCT06341673 id: IRB-2023-O3-442 briefTitle: Impact of TTNS on Bladder Symptoms Among People With MS, A RCT overallStatus: RECRUITING date: 2024-03-15 date: 2024-04-28 date: 2024-06-30 date: 2024-04-02 date: 2024-04-02 name: Hawra Al-Dandan class: OTHER briefSummary: Background: Neurogenic lower uri... |
Conclusion: Multiple sclerosis is a long-term condition, and self-management is important. TTNS provide a safe, non-invasive intervention that can be administered at home. Should the trial determine that TTNS is effective compared to sham TTNS, the investigators will plan to integrate TTNS into standard clinical care p... |
<|newrecord|> nctId: NCT06341660 id: CROC202313 briefTitle: To Evaluate the Safety and Tolerability of Carbognilumab Combined With Chemotherapy as the First-line Treatment for Patients With KEAP1 Mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer (NSCLC) overallStatus: RECRUITING date: 2023-05-25 da... |
<|newrecord|> nctId: NCT06341647 id: AB-201-01 id: 103300 (HREC 233/23) type: OTHER domain: TGA (Australia) briefTitle: Phase 1 Clinical Trial to Evaluate the Safety and Anti-Tumor Activity of AB-201 overallStatus: NOT_YET_RECRUITING date: 2024-08-31 date: 2027-04 date: 2029-02 date: 2024-04-02 date: 2024-04-02 name: G... |
* Determination of Recommended Phase 2 Dose (RP2D) primaryPurpose: TREATMENT masking: NONE count: 48 type: ESTIMATED name: AB-201 name: Cyclophosphamide name: Fludarabine measure: Incidence, severity, seriousness, and dose relationship of Adverse Events [Safety & Tolerability] measure: Determination of Recommended Phas... |
<|newrecord|> nctId: NCT06341634 id: VISIA id: TED2021-130747B-C22 type: OTHER_GRANT domain: European Union id: 3494130747-130747-28-521 type: OTHER domain: Ministry of Science and Innovation briefTitle: Surveillance of Suicide Ideation in Adolescents (VISIA) acronym: VISIA overallStatus: ENROLLING_BY_INVITATION date: ... |
The primary research question it aims to answer is: |
Is it possible to identify suicidal ideation and suicide risk in adolescents early and non-intrusively using multimodal data analysis through digital instruments equipped with artificial intelligence? |
Participants in this study will be asked to: |
Complete psychometric instruments to establish a gold standard for detecting suicide risk and suicidal ideation. |
Provide voice recordings, facial emotion data, and linguistic content in natural and specific contexts. |
Participate in salivary proteomics data collection. |
This study compares three distinct groups: |
Ideation: Adolescent patients with current suicidal ideation. Clinical Population: Psychological or psychiatric patients of the same age and gender without suicidal ideation. |
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