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General Population: Adolescents without known psychological or psychiatric pathology of the same age and gender, without suicidal ideation. |
Researchers will compare these groups to determine if the AI algorithm is effective in differentiating individuals with suicidal ideation (Group 1) from both a clinical control group (Group 2) and a general population control group (Group 3) using the collected multimodal data. The study aims to assess the algorithm's ... |
<|newrecord|> nctId: NCT06341621 id: SCHBCC-N071 briefTitle: Chemotherapy Omission in ER+/HER2- Breast Cancer With 1-3 Positive Lymph Nodes Receiving Extended Adjuvant Abemaciclib acronym: Rainbow overallStatus: RECRUITING date: 2024-04-02 date: 2027-02-25 date: 2029-01-01 date: 2024-04-02 date: 2024-04-10 name: Fudan ... |
<|newrecord|> nctId: NCT06341608 id: K23DA057528 type: NIH link: https://reporter.nih.gov/quickSearch/K23DA057528 briefTitle: Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention overallStatus: RECRUITING date: 2023-12-08 date: 2028-04 date: 2028-04 date:... |
The specific aims are to: 1) identify components of an effective telehealth intervention and barriers to implementation, 2) partner with an advisory board of OUD treatment stakeholders from different settings to develop a telehealth intervention for OUD treatment with buprenorphine, and 3) conduct a pilot trial of the ... |
The investigators will enroll 60 patients, 30 individuals who are currently enrolled in in-person OUD treatment with buprenorphine, with a treatment episode duration of 1-3 months, and 30 individuals who are not currently receiving OUD treatment but approved for treatment intake at buprenorphine clinic by an OUD treatm... |
<|newrecord|> nctId: NCT06341595 id: 123322 briefTitle: Concurrent Chemoradiotherapy Combined With Sintilimab as Neoadjuvant Therapy for GC Patients With PALM overallStatus: RECRUITING date: 2024-04-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-02 date: 2024-04-02 name: The First Affiliated Hospital with Nanjing M... |
Patients will receive sintilimab Injection (200mg iv q3w d1) combined with concurrent radiotherapy and chemotherapy. The chemotherapy regimen will use oxaliplatin 130mg/m2+S-1 40mg/m2 bid d1-14. Radiotherapy is performed using intraperitoneal radiation therapy, once a day, five times a week, at a dose of 1.8-2 Gy/f, fo... |
<|newrecord|> nctId: NCT06341582 id: 2023-10-14 briefTitle: Prediction and Evaluation by ETCOc of Neonatal Hyperbilirubinemia Cohort acronym: PREVENT overallStatus: RECRUITING date: 2023-12-11 date: 2025-11 date: 2025-11 date: 2024-04-02 date: 2024-04-02 name: Guangzhou Women and Children's Medical Center class: OTHER ... |
<|newrecord|> nctId: NCT06341569 id: 11/07.03.2024 briefTitle: Physical Therapy Students: Well-being overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2024-08-29 date: 2024-10-30 date: 2024-04-02 date: 2024-04-10 name: University of Medicine and Pharmacy "Victor Babes" Timisoara class: OTHER briefSummary: This s... |
Intervention group: second-year physical therapy students participating in a 14-week breathing techniques program. |
Control group: second-year physical therapy students who do not participate in the program but complete the same questionnaires. |
Comparison groups: 1st, 2nd, and 3rd year physical therapy students participating in assessments only. primaryPurpose: SCREENING masking: NONE count: 150 type: ESTIMATED name: Respiratory breathing techniques group measure: Assessing intrinsic and extrinsic motivation levels among physical therapy students. measure: As... |
<|newrecord|> nctId: NCT06341556 id: iNHL-03 briefTitle: A Multicenter, Prospective, Phase II Study of Zanubrutinib for Maintenance in Patients With Mantle Cell Lymphoma overallStatus: RECRUITING date: 2024-04 date: 2026-03 date: 2028-06 date: 2024-04-02 date: 2024-04-02 name: Fudan University class: OTHER briefSummary... |
<|newrecord|> nctId: NCT06341543 id: QUANTIFOT id: PHRCI-2021-68 type: OTHER_GRANT domain: DGOS (France) briefTitle: Quantiferon CMV to Identify Treatment Need For Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT) acronym: QUANTIFOT overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2026-06-15 d... |
Cytomegalovirus (CMV) infection is a frequent and potentially severe event in solid organ transplant (SOT) recipients. |
Most of available treatment display adverse effects that limit their use. Therefore, in case of an infection, it is of primary importance to identify the patients at high risk of severe infection and/or disease, and who ill benefit the most from antiviral therapy. |
As CMV infection is mainly controlled by cellular immunity, measuring specific anti-CMV T lymphocyte immunity could be an interesting tool for identifying these at-risk individuals. One of these tests is the QuantiFERON-CMV (QF-CMV) assay (QuiagenTM, Courtabœuf, France). |
Aim of the study |
The aim of the study is to determine the extent to which the QF-CMV can be use to identify, among SOT recipients with a CMV viremia, those that may not need antiviral therapy. |
Methods |
Participation to the study will be proposed to SOT recipients with an asymptomatic CMV infection with a blood viral load between 1,000 and 15,000 IU/mL. |
The QF-CMV will be performed in included participants, and the result will be given or not to the clinician in charge (according to the attributed group through randomisation). |
* In the group without result communication, the clinician in charge will determine whether a treatment is needed according to the guidelines and the local practices. |
* in the group with result communication, the clinician in charge will be advised not to introduce antiviral therapy if the result is positive, and to determine whether a treatment is needed according to the guidelines and the local practices if the result is positive. |
In the following weeks, the viral load will be monitored, along with creatininemia, cell blood count, and kalemia (to detect antiviral adverse effect). |
The participants will be sampled: |
* 5 to 12 days after QF-CMV sampling (V2) ; |
* 7 to 14 days days after V2 (V3 - between D12 and D26) ; |
* 7 to 14 days days after V3 (V4 - between D19 and D40) . |
Endpoints |
The primary endpoint is the rate of uncontrolled infection 5 to 12 days after QF-CMV sampling, defined as follows: |
* Blood CMV viral load \>10,000 IU/mL \[4 log\]; |
* And/or increase in blood viral load ≥0.5 log IU/mL with CV otherwise \>5000 IU/mL; |
* And/or the onset of CMV disease. |
The secondary endpoint is the is the occurrence antiviral adverse effects (hematoxicity or nephrotoxicity). conditions: Cytomegalovirus Infections conditions: Heart Transplantation conditions: Kidney Transplantation conditions: Lung Transplantation conditions: Liver Transplantation studyType: INTERVENTIONAL phases: NA ... |
<|newrecord|> nctId: NCT06341530 id: SURPASS-1 briefTitle: Anlotinib Combined With Penpulimab as Front-line Treatment in Advanced Non-small Cell Lung Cancer overallStatus: RECRUITING date: 2024-01-31 date: 2024-12-31 date: 2025-12-31 date: 2024-04-02 date: 2024-04-02 name: The First Affiliated Hospital of Zhengzhou Uni... |
This study intends to treat patients with advanced non-small cell lung cancer (NSCLC) confirmed by pathology with the combination of anlotinib and penpulimab injection, and observe the efficacy and safety of anlotinib and penpulimab injection in the first and second lines of NSCLC. This study is expected to provide a r... |
<|newrecord|> nctId: NCT06341517 id: IRB_in_progress briefTitle: Brain Circuitry Therapeutics for Schizophrenia acronym: ATHENA overallStatus: NOT_YET_RECRUITING date: 2024-11-05 date: 2026-01-05 date: 2027-12-12 date: 2024-04-02 date: 2024-04-02 name: Indrit Begue class: OTHER briefSummary: This project is a double bl... |
<|newrecord|> nctId: NCT06341504 id: ALVMsg2023 id: 263472 type: OTHER_GRANT domain: Fonds de recherche du Québec - Société et culture briefTitle: Prevention Messages for EGMs: Effects on Behaviours and Cognitions overallStatus: RECRUITING date: 2024-02-27 date: 2024-09 date: 2024-09 date: 2024-04-02 date: 2024-04-02 n... |
After answering a series of short questionnaires by phone, participants are asked to schedule a gambling session which is done in a laboratory on the university's campus. This laboratory replicates a typical bar, and is equipped with real EGMs. Participants are recruited under the false pretense of giving their opinion... |
After having stopped by their own volition (some exceptions apply, see "Detailed Description" for further details), participants are debriefed on the real goals of this study and reimbursed any incurred losses while gambling. They are then be asked to answer another series of questionnaires. conditions: Gambling studyT... |
* Experimental: Regular gambling session + Prevention pop-up messages |
* Active Comparator: Regular gambling session |
Three assessment phases: |
* Pre-experiment. Telephone interview before the gambling session. Measures baseline characteristics and schedule the gambling session. Usually done within a couple of days following an application to participate. |
* Experiment. Gambling session in the laboratory. Behaviour is continuously measured starting with the first time the participant puts money in the EGM to participant choosing to end their gambling session. Duration is limited to 2 hrs (unbeknownst to participant). Session is scheduled days to weeks after the Pre-exper... |
* Post-experiment. Debriefing and post-experiment interview. Done right after the gambling session is ended. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Participants are recruited under the false pretense of evaluating the realism of a gambling session in a laboratory replicating a bar environment. W... |
Note that masking becomes "open label" after debriefing. Indeed, after being informed of the true goals of this study, participants will easily be able to determine in which group they were assigned based on what occured during their gambling session. Though, gambling behaviours are recorded before debriefing and won't... |
There is no functional way to mask group assignment to the members of the research team. However, the randomization procedure assures that allocation is purely random. whoMasked: PARTICIPANT count: 80 type: ESTIMATED name: Prevention pop-up messages name: Mandatory time limit name: Responsible gambling information name... |
<|newrecord|> nctId: NCT06341491 id: obs. Delay Discounting briefTitle: The Study of Delay Discounting Among Beneficiaries of the Pé-de-Meia Program overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-04-30 date: 2025-12-01 date: 2024-04-02 date: 2024-04-02 name: Federal Institute of Education, Science and Te... |
How does the "Pé-de-Meia" Program affect the students' propensity for delay discounting? Is there a relationship between the level of delay discounting among students, their academic performance, and school attendance? Participants in the study, high school students enrolled in the "Pé-de-Meia" Program, will undergo as... |
<|newrecord|> nctId: NCT06341478 id: IG-2022-27746 briefTitle: Investigator Grant (IG) 2022 27746 overallStatus: RECRUITING date: 2024-03-15 date: 2026-03-15 date: 2027-03-15 date: 2024-04-02 date: 2024-04-02 name: IRCCS San Raffaele class: OTHER briefSummary: Background: |
Muscle-invasive bladder cancer (MIBC) is a systemic disease as \>40% of patients (pts) ultimately develop recurrence after radical cystectomy (RC). For pts who cannot receive or refuse cisplatin-based chemotherapy there is no standard-of-care neoadjuvant therapy. Single-agent pembrolizumab, given neoadjuvantly in patie... |
Hypothesis: |
By developing a robust biomarker program associated with therapeutic benefit of novel therapies or their combinations, along with an imaging biomarker development, the investigators will be able to identify suitable tumor characteristics for personalizing perioperative therapies in MIBC, coupled with the possibility to... |
Aims: |
The project is aimed at characterizing the tumor and microenvironment characteristics of muscle-invasive bladder cancer, with a special focus on their changes induced by various neoadjuvant therapies preceding radical cystectomy. |
The investigators will aim to evaluate the tumor and immune profile on matched pre- vs post-therapy samples and noninvasively monitor the response to treatment with the use of radiological assessments. |
Experimental design: |
The investigators will access tumor samples from matched pre-therapy (transurethral resection of the bladder tumor) and post-therapy (radical cystectomy) surgical interventions. They will also analyze the imaging analyses of combined bladder multiparametric MRI/Fluorodeoxyglucose Positron Emission Tomography (PET) scan... |
Biomarker analyses will include the following: i.) multiplex immunofluorescence assays will allow the investigators defining the immune contexture of tumor lesion; ii.) multiparametric flow cytometry will allow the phenotypic and functional analysis of peripheral blood cells at single cell level; iii.) a whole transcri... |
Expected results: |
The investigators will expect to identify the tumor characteristics and immune-profiling enabling them to delineate the selection of patients most suited for certain novel perioperative therapies, thus anticipating the developments in clinical research that are being conducted worldwide in MIBC. |
The investigators will be also able to develop noninvasive tools for pathological complete response identification, thus enabling them to develop a next-generation of clinical trials aimed at sparing any radical local therapy on the bladder tumor. |
Impact on cancer: |
In principle, the present personalized strategy yields the potential to enhance the therapeutic standards achievable with RC alone as well as with single-agent immunotherapy and RC. conditions: Bladder Cancer studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDe... |
<|newrecord|> nctId: NCT06341465 id: HÜ- FTR- BD- 3 briefTitle: Investigation of the Effects of Exercise and Kinesiological Taping on Spinal Deformities and Serum Markers in Individuals With Scoliosis overallStatus: NOT_YET_RECRUITING date: 2024-04-04 date: 2024-07-04 date: 2024-07-04 date: 2024-04-02 date: 2024-04-02 ... |
<|newrecord|> nctId: NCT06341452 id: HD-NaM-01-EU briefTitle: Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis acronym: SODIAH overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-03 date: 2025-12 date: 2024-04-02 date: 2024-04-02 name: Fresenius Medical Care Deutschland Gm... |
<|newrecord|> nctId: NCT06341439 id: Prot. 001_2023 briefTitle: Clinical Efficacy of Mouthrinses Based on Chlorhexidine 0.12% and CITROX® overallStatus: ACTIVE_NOT_RECRUITING date: 2023-02-18 date: 2024-01-18 date: 2024-03-30 date: 2024-04-02 date: 2024-04-02 name: University of L'Aquila class: OTHER briefSummary: The ... |
* Is the response to periodontal therapy better if mouthwash containing Citrox is used? |
* What is the patients' perception? |
Participants, divided into 2 groups, are asked to use either one or the other mouthwash for 14 days after non-surgical periodontal therapy. conditions: Periodontitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPAN... |
<|newrecord|> nctId: NCT06341426 id: 23-5872 briefTitle: Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin acronym: PSI-1V2 overallStatus: RECRUITING date: 2024-02-05 date: 2028-02-01 date: 2028-08-01 date: 2024-04-02 date: 2024-04-02 name: University Hea... |
<|newrecord|> nctId: NCT06341413 id: 2023-1281 id: A539500 type: OTHER domain: UW- Madison id: SMPH/SLEEP CENTER/SLEEP CTR type: OTHER domain: UW- Madison id: Protocol version 1/17/2024 type: OTHER domain: UW- Madison id: 1R01MH132221 type: NIH link: https://reporter.nih.gov/quickSearch/1R01MH132221 briefTitle: Sleep a... |
Participants will attend 4 study visits: |
* A clinical and trauma assessment visit |
* A testing day that may include cognitive testing, surveys, and an MRI. |
* An overnight sleep study following one week of at-home sleep recordings with the device in the sham condition |
* An overnight sleep study following one week of at-home sleep recordings with the device in the sleep enhancement condition conditions: Post Traumatic Stress Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT... |
<|newrecord|> nctId: NCT06341400 id: 2024-KY-030-01 briefTitle: RC48 Combined With Toripalimab as Neoadjuvant Therapy for Cisplatin Ineligible MIBC Patients overallStatus: RECRUITING date: 2024-05-20 date: 2026-05-01 date: 2027-05-01 date: 2024-04-02 date: 2024-04-02 name: Zhujiang Hospital class: OTHER briefSummary: A... |
<|newrecord|> nctId: NCT06341387 id: R178522-ieo1906 briefTitle: Volatolomic and Proteomic Profile for Early Diagnosis of Lung Cancer overallStatus: RECRUITING date: 2023-05-05 date: 2024-05-30 date: 2024-07-31 date: 2024-04-02 date: 2024-04-02 name: European Institute of Oncology class: OTHER name: University of Rome ... |
* Which are the "omics" biomarkers that characterize the early stage of lung cancer? |
* How to Translate Laboratory Data into Clinical Data? |
For each participant we will collected the breath, urine and blood samples. In lung cancer patients group the samples will be sample before lung cancer resection. The samples of Breath, urine and serum will be analysed using different type of analysis: eNose and the Gas Chromatography combined with Ion Mass Spectrometr... |
<|newrecord|> nctId: NCT06341374 id: 2023/5079 briefTitle: Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients overallStatus: RECRUITING date: 2023-11-06 date: 2024-03-30 date: 2024-09-30 date: 2024-04-02 date: 2024-04-02 name: Parc Taulí Hospital Universitari class: OTHER briefSummary: Sleep is an import... |
The objective of this study is to evaluate the impact of undiagnosed and non-treated sleep disorders on innate immunity in a cohort of COVID-19 patients and the role of trained immunity induced by influenza vaccination in the innate immune response. conditions: Apnea, Obstructive Sleep conditions: SARS CoV 2 Infection ... |
<|newrecord|> nctId: NCT06341361 id: OCT-FFR briefTitle: OCT-based Machine Learning FFR for Predicting Post-PCI FFR overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-04-30 date: 2025-10-15 date: 2024-04-02 date: 2024-04-02 name: Yonsei University class: OTHER name: Gangnam Severance Hospital name: Severance... |
<|newrecord|> nctId: NCT06341348 id: Dalin Tzuchi Hospital briefTitle: Effects of Case Management for Patients With Rheumatoid Arthritis in Taiwan overallStatus: COMPLETED date: 2016-01-01 date: 2018-06-30 date: 2018-12-31 date: 2024-04-02 date: 2024-04-02 name: Dalin Tzu Chi General Hospital class: OTHER briefSummary:... |
A quasi-experimental pre-post test, control-group study with purposive sampling recruited RA patients from a hospital in Taiwan during 2016-2017. CM program was composed of health education sessions and follow-up telephone consultations over a six-month period. A review of medical records and structured questionnaires ... |
This evidence-based study may be beneficial to characterize the long-term effectiveness of CM for Taiwanese patients with RA, and may be a reference for healthcare providers in facilitating the provision of appropriate interventions to improve the adaptation processes and clinical outcomes for them. conditions: Case Ma... |
<|newrecord|> nctId: NCT06341335 id: AK109-301 briefTitle: A Study of AK104/Placebo Plus AK109/Placebo And Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-11 date: 2027-07 date: 2024-04-02 date: 2024-04-02 name: Akeso class: INDUSTRY briefSumm... |
<|newrecord|> nctId: NCT06341322 id: ERC0003996 briefTitle: Using Behavioural and Cultural Insights to Increase Colorectal Cancer Home-testing in Croatia overallStatus: RECRUITING date: 2024-03-05 date: 2024-04 date: 2024-07 date: 2024-04-02 date: 2024-04-02 name: Veerle Snijders class: OTHER name: Croatian Institute o... |
The Croatian Institute of Public Health with technical support from World Health Organization (WHO) Regional Office for Europe is undertaking a mixed-methods research study with the aim to increase the completion of colorectal cancer home testing and improve our knowledge of the barriers and drivers to do so. The study... |
1. Quantitative: testing the introduction of a reminder letter to encourage people to respond to the initial invite to participate in the CRC home test program and test which elements of a reminder letter improve response rates. |
The quantitative component consists of a four-arm reminder letter randomized controlled trial (RCT) comparing no letter, standard letter, behaviorally informed letter, and behaviorally informed letter sent with a home testing kit to investigate the effectiveness of reminders in increasing uptake of home-testing for col... |
2. Qualitative: conducting in-depth interviews with people from the target population who did or did not respond to the CRC invite letter and reminder to better understand the barriers and drivers to participation. |
The qualitative component consists of 24 in-depth interviews (IDIs) conducted with members of the target population to identify barriers and drivers to completing colorectal cancer screening home-testing. Data collection for IDIs will be face-to-face, using discussion guides, and will be audio recorded. The audio-recor... |
<|newrecord|> nctId: NCT06341309 id: CSPC-DEY-CRC-K09 briefTitle: Exploratory Study of Irinotecan Liposomes in Maintenance Therapy of Metastatic Colorectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-08-01 date: 2024-04-02 date: 2024-04-02 name: West China Hospital class: OTHER... |
<|newrecord|> nctId: NCT06341296 id: CSPC-DEY-CRC-K07 briefTitle: Phase II Study of Irinotecan Liposomes in First-line Treatment of Metastatic Colorectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-12 date: 2024-04-02 date: 2024-04-02 name: West China Hospital class: OTHER briefSumma... |
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