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<|newrecord|> nctId: NCT06341283 id: BCOOS2024 briefTitle: A Retrospective Real-world Study of Abemaciclib Tablets Based on HIS System in HR+ Breast Cancer Patients overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-31 date: 2025-07-01 date: 2024-04-02 date: 2024-04-02 name: The Affiliated Hospital of Qin... |
<|newrecord|> nctId: NCT06341270 id: 2024HX1564 briefTitle: Efficacy of TEAS on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2026-04-20 date: 2026-12-20 date: 2024-04-02 date: 2024-04-18 name: West China Hospital class: OTHER briefSummary: T... |
<|newrecord|> nctId: NCT06341257 id: VGHTCCTC_SCART001 briefTitle: Efficacy and Toxicity of SCART overallStatus: RECRUITING date: 2024-01-01 date: 2026-12-31 date: 2029-12-31 date: 2024-04-02 date: 2024-04-02 name: Taichung Veterans General Hospital class: OTHER briefSummary: This study is expected to enroll patients f... |
<|newrecord|> nctId: NCT06341244 id: UNIFESP briefTitle: Air Stacking Technique Efficacy on Peak of Expiratory Flow and Cough Peak Flow in Non-cardiac Thoracic Surgery overallStatus: COMPLETED date: 2019-08-20 date: 2020-11-05 date: 2022-12-15 date: 2024-04-02 date: 2024-04-02 name: Universidade Cidade de Sao Paulo cla... |
<|newrecord|> nctId: NCT06341231 id: 202400248 briefTitle: Personalized Anticoagulant Therapy for Pulmonary Thromboembolism overallStatus: RECRUITING date: 2024-02-01 date: 2026-12-31 date: 2027-12-31 date: 2024-04-02 date: 2024-04-02 name: Xiangya Hospital of Central South University class: OTHER briefSummary: The goa... |
* To analyze the influencing factors of the efficacy and safety of anticoagulant therapy for specific populations with pulmonary thromboembolism (PTE) in the real world (such as the elderly, those with impaired kidney function, and individuals with malignant tumors). |
* Whether we can use machine-learning models to predict bleeding events and VTE recurrence in special populations following anticoagulant therapy in the real world? Participants will receive diagnostic and therapeutic measures for pulmonary thromboembolism in accordance with clinical guidelines, including anticoagulant... |
<|newrecord|> nctId: NCT06341218 id: 21-5T/3 briefTitle: The Effect Of Simulation-Supported Pediatric CPR Training Based On CRM On Knowledge, Attitude, And Performance overallStatus: COMPLETED date: 2021-02-25 date: 2023-09-30 date: 2023-11-15 date: 2024-04-02 date: 2024-04-02 name: Zonguldak Bulent Ecevit University c... |
<|newrecord|> nctId: NCT06341205 id: 22-APN-01 briefTitle: Personalized Rituximab Treatment Based on Artificial Intelligence in Membranous Nephropathy (iRITUX) acronym: iRITUX overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2031-08-31 date: 2031-09-30 date: 2024-04-02 date: 2024-04-02 name: Centre Hospitalier ... |
The identification of autoantibodies - e.g., the phospholipase A2 receptor type 1 (PLA2R1) - has promoted the use of immunosuppressive drugs such as rituximab which is now a safe and effective first-line treatment for the management of membranous nephropathy. However, up to 40% of patients do not respond to a first cou... |
Recently, the investigators have shown that after two 1-g rituximab infusions, the rituximab blood level 3 months after the first rituximab infusion, was correlated with the likelihood of remission after 6 and 12 months of the rituximab treatment. Patients with positive rituximab blood level 3 months after treatment ha... |
Nowadays, machine learning algorithms are increasingly used in medicine, especially in pharmacology, to predict the exposure to a drug, the initial dose to administer or the interval between two infusions. |
The objective of this study is to use a machine learning algorithm predicting the risk of having an undetectable residual level of rituximab 3 months after treatment, in order to propose a personalized treatment management with early additional doses of rituximab for the patients at risk. conditions: Membranous Nephrop... |
<|newrecord|> nctId: NCT06341192 id: ChangGungMH ALL SB DB briefTitle: Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction acronym: ALLR overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-08-31 date: 2026-10-31 date: 2024-04-02 date: 2024-04-26 name... |
* What are the optimal criteria for selecting between single-bundle ACL reconstruction combined with anterolateral ligament (ALL) reconstruction versus double-bundle ACL reconstruction combined with ALL reconstruction? |
* How do these two surgical techniques compare in terms of post-operative knee stability, functional outcomes, and reducing re-tear rates? |
Participants will: |
* Undergo pre-operative MRI imaging, ligament stability testing, and motion analysis evaluations |
* Be randomly assigned to either: |
* Single-bundle ACL + ALL reconstruction |
* Double-bundle ACL + ALL reconstruction |
* Receive the assigned surgical procedure |
* Participate in post-operative follow-ups, ligament stability testing, and motion analysis at 6 months and 1 year |
Researchers will compare the single-bundle ACL + ALL group and the double-bundle ACL + ALL group to see if one technique demonstrates superior knee stability, functional outcomes (e.g. return to sport ability), and lower ACL re-tear rates. conditions: Anterior Cruciate Ligament Injuries conditions: Anterior Cruciate Li... |
* Patients in this group will undergo reconstruction of the anterior cruciate ligament (ACL) using a single-bundle graft technique. |
* In addition, they will have the anterolateral ligament (ALL) reconstructed using a portion of the same graft material. |
* For the ALL reconstruction, a commonly used technique is the Sonnery-Cottet ALL reconstruction using a split graft. |
Double-Bundle ACL + ALL Reconstruction Group: |
* Patients in this group will undergo anatomic double-bundle ACL reconstruction using two graft bundles to more anatomically replicate the native ACL's anteromedial and posterolateral bundles. |
* Like the single-bundle group, they will also have supplemental ALL reconstruction performed using a portion of the graft material. |
* The double-bundle ACL reconstruction aims to better restore the ACL's complex anatomic footprint and bundles' tension patterns. primaryPurpose: TREATMENT masking: NONE count: 40 type: ESTIMATED name: Single-bundle ACL combined anterolateral ligament reconstruction name: Double-bundle ACL combined anterolateral ligame... |
<|newrecord|> nctId: NCT06341179 id: M2S id: H-23063352 type: OTHER domain: Vek.dk briefTitle: Effect of Sleep Extension on Overweight and Learning in Children acronym: More2Sleep overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-12-31 date: 2027-12-31 date: 2024-04-02 date: 2024-04-02 name: University of C... |
The primary objective is to assess the effects of sleep extension by \~45 min/night, achieved by going to bed 60-90 min earlier, on adiposity and learning ability in school-aged children who are overweight or obese, and sleep less than recommended for their age. conditions: Sleep Duration conditions: Child Obesity cond... |
<|newrecord|> nctId: NCT06341166 id: CCM1959 briefTitle: Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse acronym: SCIMITAR overallStatus: RECRUITING date: 2023-06-19 date: 2025-06-19 date: 2025-06-19 date: 2024-04-02 date: 2024-04-02 name: Centro Cardiologico Monzino ... |
<|newrecord|> nctId: NCT06341153 id: SelcukUni2542 briefTitle: The Effect Of Breast Milk Sniffing And Tasting On Early Feeding Tips overallStatus: COMPLETED date: 2022-07-15 date: 2022-09-15 date: 2023-11-15 date: 2024-04-02 date: 2024-04-02 name: Sibel Küçükoğlu class: OTHER name: Health Institutes of Turkey briefSumm... |
Inclusion Criteria; For the mother; |
* Having a term and healthy baby, |
* No communication and language problems, |
* No maternal illness preventing breastfeeding (active chemotherapy, HIV positive, neurological or psychological problems, etc.), |
* Willingness to breastfeed, For the baby; |
* Not having a disease condition that prevents breastfeeding (cleft palate, cleft lip, galactotemia, choanal atresia, etc.), |
* Being at normal birth weight (2500gr-4000gr), |
* Apgar score of 7 and above. whoMasked: INVESTIGATOR count: 72 type: ACTUAL name: Breast Milk Odor Stimulation name: Stimulation of Breast Milk Smell and Taste measure: Introductory Information Form measure: Early Feeding Tips Scale measure: Breastfeeding Identification and Assessment Scale (LATCH) measure: Early Feed... |
<|newrecord|> nctId: NCT06341140 id: secil koken briefTitle: The Effect of Breastfeeding Support on Exclusive Breastfeeding, Occurrence of Breast Problems and Breastfeeding Self-Efficacy overallStatus: COMPLETED date: 2021-08-01 date: 2022-11-30 date: 2023-02-06 date: 2024-04-02 date: 2024-04-02 name: Celal Bayar Unive... |
<|newrecord|> nctId: NCT06341127 id: 2023-01 briefTitle: Fluoxetine in KCNC1-related Disorder overallStatus: ENROLLING_BY_INVITATION date: 2024-01-17 date: 2024-12-01 date: 2025-12-31 date: 2024-04-02 date: 2024-04-02 name: Holland Bloorview Kids Rehabilitation Hospital class: OTHER name: The Hospital for Sick Children... |
<|newrecord|> nctId: NCT06341114 id: BAT-8008-1308-001-CR briefTitle: A Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of the Combination of BAT8008 With BAT1308 in Patients With Advanced Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-04-12 date:... |
This study aims to explore the safety, tolerability, and pharmacokinetic characteristics of BAT8008 combined with BAT1308 in patients with advanced solid tumors, determine the maximum tolerated dose (MTD), provide recommended doses and reasonable dosing regimens for subsequent clinical studies, and preliminarily evalua... |
The study is divided into two stages. The first stage will use a "3+3" dose escalation design to explore the safety and tolerability of the investigational drugs. In the second stage, based on the preliminary safety and efficacy results from the first stage, appropriate doses and tumor types will be selected for expans... |
<|newrecord|> nctId: NCT06341101 id: 2022-503135-33-00 id: 2022-503135-33-00 type: OTHER domain: EU trial number briefTitle: Timely Recovery After Subclinical Heart Failure acronym: TREASURE overallStatus: RECRUITING date: 2024-03-26 date: 2026-03-01 date: 2026-03-01 date: 2024-04-02 date: 2024-04-02 name: Academisch Z... |
1. Reversibility of structural and functional myocardial impairment in asymptomatic HF towards healthy values; |
2. The progression from asymptomatic to symptomatic HF (symptoms scored based on the NYHA criteria); |
3. Cardiovascular performance (volume- and pressure load), cardio metabolic risk factors (glucose metabolism, lipid status, kidney function) and quality of life (questionnaires); |
4. Novel biomarkers and relevant microRNA's indicative for hypertrophy, fibrosis inflammation and ischemia. |
Eligible subjects will be counselled and upon informed consent randomized for either medication group (n=65) or care as usual group (n=65). After a complete cardiovascular assessment, medication will be initiated open-labeled (Perindopril 2 mg or no medication). Thereafter, standard medical check-ups (blood pressure, E... |
Researchers will compare ACE inhibitor (Perindopril 2 mg) and care as usual (i.e. no medication) to investigate whether ACE inhibitor allows timely recovery after subclinical heart failure. conditions: Heart Failure conditions: Diastolic Dysfunction studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interv... |
<|newrecord|> nctId: NCT06341088 id: B.30.2.ATA.0.01.00/132 briefTitle: Evaluation of Anatomical Results and Sexual Functions After Unilateral and Bilateral Laparoscopic Suture Sacro-hysteropexy Operations overallStatus: RECRUITING date: 2024-04-05 date: 2024-07-05 date: 2024-10-05 date: 2024-04-02 date: 2024-04-02 nam... |
<|newrecord|> nctId: NCT06341075 id: KY2024-053-02 briefTitle: Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy overallStatus: ENROLLING_BY_INVITATION date: 2024-03-14 date: 2025-03-14 date: 2026-03-14 date: 2024-04-02 date: 2024-04-02 name: Beijing Tiantan Ho... |
<|newrecord|> nctId: NCT06341062 id: M2024078 briefTitle: The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-06-30 date: 2026-06-30 date: 2024-04-02 date: 2024-04-02 name: Peking University Third Hospital class: OTHER briefSummary:... |
1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation. |
2. To explore the relationship between renal microcirculation and systemic hemodynamics. |
3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery. conditions: Intensive Care Unit conditions: Acute Kidney Injury conditions: Ultrasound studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count... |
<|newrecord|> nctId: NCT06341049 id: 2024-03/14 briefTitle: Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial overallStatus: RECRUITING date: 2024-03-12 date: 2024-06-12 date: 2025-09-12 date: 2024-04-02 date: 2024-04-02 name: Ataturk University class: OTHER b... |
<|newrecord|> nctId: NCT06341036 id: Thrombocytosis in Children briefTitle: Aetiology And Outcome Of Children With Thrombocytosis Admitted to Assiut University Children Hospital overallStatus: NOT_YET_RECRUITING date: 2024-07-15 date: 2025-03-03 date: 2026-03-03 date: 2024-04-02 date: 2024-04-02 name: Assiut University... |
<|newrecord|> nctId: NCT06341023 id: 2023-1430 briefTitle: Functional Balance Intervention in Multiple Sclerosis acronym: FBIinMS overallStatus: NOT_YET_RECRUITING date: 2024-04-14 date: 2026-01-09 date: 2027-01-09 date: 2024-04-02 date: 2024-04-03 name: University of Illinois at Chicago class: OTHER briefSummary: This... |
Study 1: Effect of lab-based Functional Balance Intervention (FBI) for physical and cognitive symptoms of Multiple Sclerosis. |
Study 2: Feasibility of home-based FBI for physical and cognitive symptoms of Multiple Sclerosis. |
Each study involves a 2-arm, Phase-1, randomized controlled clinical trial to evaluate the effect of FBI on physical, cognitive function, and daily living among people with MS (PwMS). Study 1 is conducted in a lab setting, while Study 2 is conducted at home with additional safety measures. A total of 150 people with mu... |
<|newrecord|> nctId: NCT06341010 id: The Role of Angiojet Rheolytic briefTitle: The Role of Angiojet Rheolytic Thrombectomy in The Management of Iliofemoral Deep Venous Thrombosis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-01-01 date: 2026-09-01 date: 2024-04-02 date: 2024-04-02 name: Abdelrahman Ibr... |
<|newrecord|> nctId: NCT06340997 id: Mitral Stenosis briefTitle: Impact of Percutaneous Transvenous Mitral Commissurotomy on The Left Atrial Appendage Function in Patients With Mitral Stenosis. overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-10-01 date: 2027-08-01 date: 2024-04-02 date: 2024-04-02 name: A... |
<|newrecord|> nctId: NCT06340984 id: sICAM-1 in acne vulgaris briefTitle: Serum Intercellular Adhesion Molecule -1 in Acne Vulgaris Patients : Effect of Montelukast overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-11 date: 2025-02 date: 2024-04-02 date: 2024-04-03 name: South Valley University class: OTHER br... |
1. Evaluation of serum soluble intercellular adhesion molecule-1 (sICAM-1) level in acne vulgaris and compare it to control group |
2. Evaluate its role in acne pathogenesis and its correlation with acne vulgaris severity |
3. Evaluate the effect of Montelukast on serum (sICAM-1) level in acne vulgaris conditions: Acne Vulgaris studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: M... |
<|newrecord|> nctId: NCT06340971 id: 331247 briefTitle: Air Pollution and Pregnancy acronym: PTB overallStatus: RECRUITING date: 2024-09-01 date: 2029-08-31 date: 2029-08-31 date: 2024-04-02 date: 2024-04-02 name: Queen Mary University of London class: OTHER name: University College London Hospitals briefSummary: We ar... |
We aim to develop and validate a deep learning model to predict the risk of preterm birth and other adverse pregnancy outcomes using data from EPIC electronic health records at University College London Hospital Trust (UCLH) for a cohort of 18000 patients. We will obtain corresponding data on exposure to ambient pollut... |
<|newrecord|> nctId: NCT06340958 id: CLE100-MDD-202 briefTitle: A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder acronym: SOLEO overallStatus: RECRUITING date: 2024-03-18 date: 2025-07-11 date: 2026-01-10 date: 2024-04-02 date: 2024-04-10 name: Cl... |
<|newrecord|> nctId: NCT06340945 id: S2023-761-01 briefTitle: The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-12-31 date: 2029-12-31 date: 2024-04-02 date: 2024-04-02 name: Chinese PLA General Hospital class: OTHER briefSummary:... |
2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided thermal ablation in the treatment of benign thyroid nodules conditions: Thyroid Nodules studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count:... |
<|newrecord|> nctId: NCT06340932 id: CRS-119 (Pro00077191) briefTitle: Impact of Opioid Avoidance Protocol for ACL Reconstruction overallStatus: NOT_YET_RECRUITING date: 2024-03-28 date: 2024-08-15 date: 2024-10-01 date: 2024-04-02 date: 2024-04-02 name: Matthew Varacallo class: OTHER name: Pacira Biosciences briefSumm... |
The primary objective of this study is to evaluate the effect of the opioid avoidance protocol on opioid use in MME from POD0-7 after ACLR compared to the current standard of care pain management protocol. |
Secondary objectives are to: |
* evaluate the effects of an opioid avoidance protocol on the daily average NRS pain scores from POD0-7 |
* evaluate the effects of an opioid avoidance protocol on the daily worst NRS pain score from POD0-7 |
* evaluate the ability to recover opioid free through 7, 30, and 60 days |
* evaluate the QoR-15 scores on POD2 |
* assess the number of opioid prescriptions required by patients in the 60 day recover period |
* assess KOOS pain and symptom scales at 8 weeks post-operatively between groups. conditions: ACL Tear conditions: Post Operative Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED name: Iovera name: Celecoxib name: Acetaminophen name: Oxycodone name: Tramado... |
<|newrecord|> nctId: NCT06340919 id: 1406014978-241 briefTitle: Hearing Aid Algorithms for Sudden Sounds overallStatus: ENROLLING_BY_INVITATION date: 2024-02-21 date: 2024-09-30 date: 2025-05-31 date: 2024-04-02 date: 2024-04-02 name: Purdue University class: OTHER name: Oticon briefSummary: This study explores the imp... |
<|newrecord|> nctId: NCT06340906 id: 4573 id: UCI 23-29 type: OTHER domain: CFCCC briefTitle: Electroacupuncture in Symptom Management After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-11-15 date: 2026-01-30 date: 2024-04-02 date: 202... |
<|newrecord|> nctId: NCT06340893 id: 76117 briefTitle: Exercise Training in Children With Communication Impairments overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-08-31 date: 2024-08-31 date: 2024-04-02 date: 2024-04-02 name: Marquette University class: OTHER name: University of Arizona briefSummary: Thi... |
All children (DLD and typically developing) will undergo communication, fine/gross motor and fitness testing. Children will be randomly assigned to participate in an exercise program (n =20) or to a restful play program (n = 20). Both programs will take place 3x/week for 6 weeks and children will only participate in on... |
Children in the exercise program will do activities to train cardiovascular fitness, agility, balance, strength, and endurance while children in the restful play condition will do things like play with legos and color. |
Researchers will compare changes in learning tasks and fitness levels for children (DLD and typically developing) who participated in the exercise program vs. restful play program. conditions: Developmental Language Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interve... |
<|newrecord|> nctId: NCT06340880 id: SAPB briefTitle: Serratus Anterior Plane Block, Ultrasound vs Anatomical Landmark Guided. overallStatus: RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-04-02 date: 2024-04-02 name: Menoufia University class: OTHER briefSummary: This prospective, double-blinded rando... |
<|newrecord|> nctId: NCT06340867 id: 30723 briefTitle: Intraoral Scanner With and Without Orthodontic Brackets overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-03-24 date: 2024-04-01 date: 2024-04-02 date: 2024-04-02 name: Cairo University class: OTHER briefSummary: this study aim to evaluate the effect... |
<|newrecord|> nctId: NCT06340854 id: NN1436-7724 id: U1111-1292-6151 type: OTHER domain: World Health Organization (WHO) id: 2023-506084-34 type: OTHER domain: European Medical Agency (EMA) briefTitle: A Research Study to See How Switching From a Daily Basal Insulin to a New Weekly Insulin, Insulin Icodec, Helps in Red... |
<|newrecord|> nctId: NCT06340841 id: LEMURS SSI 24 briefTitle: LEMURS SSI: Evaluation of Behavioral Incentives acronym: LEMURSSI overallStatus: RECRUITING date: 2024-02-12 date: 2024-05-31 date: 2028-05-31 date: 2024-04-02 date: 2024-04-02 name: University of Vermont class: OTHER briefSummary: The goal of this substudy... |
<|newrecord|> nctId: NCT06340828 id: 2023-KY-186-01 briefTitle: Washed Microbiota Transplantation Alleviates Diabetic Gastrointestinal Motility Disorders: an Efficacy and Safety Study overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2027-07-20 date: 2027-07-20 date: 2024-04-02 date: 2024-04-03 name: The Second ... |
* The risk factors of diabetic gastrointestinal motility disorders in routine clinical data or biochemical tests. |
* The composition of gut microbiota in diabetic gastrointestinal motility disorders patients and potential pathogenic bacteria. |
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