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Secondary outcomes will include: |
* Statistic metric of association between P0.1, ΔP, PMI and ΔPes |
* Statistic metric of association between P0.1, ΔPocc, ΔP, PMI and PaO2/FiO2 ratio |
* Statistic metric of association between P0.1, ΔPocc, ΔP, PMI and tidal volume |
* Statistic metric of association between P0.1, ΔPocc, ΔP, PMI and DTF% |
* Statistic metric of association between P0.1, ΔPocc, ΔP, PMI and Ex/DTF% |
* Statistic metric of association between P0.1, ΔPocc, ΔP, PMI and respiratory rate, VAS dyspnea and VAS discomfort. |
Participants will undergo the following tasks and treatments: |
* Complete written informed consent before enrollment. |
* Post-extubation noninvasive ventilation via nose-to-mouth and full-face masks. |
* Monitoring of esophageal pressure (in all patients the catheter will be placed before extubation, according to clinical judgment, and its correct position will be verified through a positive pressure occlusion test) |
* Continuous recording of airway pressure, flow, and esophageal pressure (Pes), using a dedicated pneumotachograph and pressure transducer. |
* Sudden end-inspiratory and end-expiratory occlusion maneuvers, to measure plateau pressure (Pplat) and end-expiratory airway occlusion pressure (ΔPocc), respectively. |
* Collection of hemodynamic and arterial blood-gas parameters, performed according to clinical judgment, along with assessments of dyspnea and discomfort using a modified visual analogue scale (VAS). |
* Diaphragm ultrasound during occlusion maneuvers, measuring diaphragm displacement, diaphragm thickening fraction (DTF%), and diaphragmatic excursion (Ex) under various conditions. conditions: Respiratory Disease conditions: Artificial Respiration studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PR... |
<|newrecord|> nctId: NCT06344221 id: 2023-A00954-41 briefTitle: Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study acronym: HapticS overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-07-15 date: 2024-07-15 date: 2024-04-03 date: 2024-04-03 name: Centre Hospitalier St Anne class: OTH... |
<|newrecord|> nctId: NCT06344208 id: IEO 1647 briefTitle: Predicting Toxicity in Elderly Patients With Head and Neck Cancer acronym: PREtoxEL overallStatus: RECRUITING date: 2022-03-15 date: 2024-12-31 date: 2024-12-31 date: 2024-04-03 date: 2024-04-03 name: European Institute of Oncology class: OTHER briefSummary: Pre... |
validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes. conditions: Head and Neck Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3 type: ESTIMATED measure: Predicting toxicity in elderly patients with ... |
<|newrecord|> nctId: NCT06344195 id: 2517 briefTitle: Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening acronym: Antiviral overallStatus: RECRUITING date: 2024-03-27 date: 2024-04 date: 2024-05 date: 2024-04-03 date: 2024-04-10 name: Dow University of Health Scien... |
There will be 82 participants, (41 in each group) Group A will receive Valacyclovir Group B will receive standard treatment i.e. Naproxen Sodium. Pain level will be assessed by using Numeric rating scale for 6 days conditions: Acute Apical Abscess studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interven... |
<|newrecord|> nctId: NCT06344182 id: STarkan briefTitle: Reliability, Concurrent Validity and Minimal Detectable Change of the Step Up and Down Test in Patients With Total Knee Arthroplasty overallStatus: COMPLETED date: 2021-02-01 date: 2021-05-15 date: 2021-05-15 date: 2024-04-03 date: 2024-04-03 name: Dokuz Eylul Un... |
<|newrecord|> nctId: NCT06344169 id: DTCRD112(2)-I-15 briefTitle: Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-03-14 date: 2026-06-14 date: 2024-04-03 date: 2024-04-22 name: Dalin Tzu Chi General Hospital class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06344156 id: PDAC-Neoantigen briefTitle: Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy as an Adjuvant Therapy for Pancreatic Cancer overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2027-04-01 date: 2024-04-03 date: 2024-04-03 name: Sichuan University class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06344143 id: 24-324 briefTitle: Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma acronym: MACS overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2029-11-01 date: 2030-12-31 date: 2024-04-03 date: 2024-04-26 name: The Cleveland Clinic class: OTHER name: R... |
<|newrecord|> nctId: NCT06344130 id: 10001859 id: 001859-C briefTitle: Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-12-31 date: 2027-12-31 date: 2024-04-03 date: 2024-04-26 name: National Cancer Institute (NCI) class: NI... |
Glioblastoma (GBM) is a cancer of the brain. Current survival rates for people with GBM are poor; survival ranges from 5.2 months to 39 months. Most tumors come back within months or years after treatment, and when they do, they are worse: Overall survival drops to less than 10 months. No standard treatment exists for ... |
Objective: |
To find a safe schedule for using radiation to treat GBM tumors that returned after initial radiation treatment. |
Eligibility: |
People aged 18 years and older with grade 4 GBM that returned after initial radiation treatment. |
Design: |
Participants will be screened. They will have a physical exam with blood tests. A sample of tumor tissue may be collected. |
Participants will undergo re-irradiation planning: They will wear a plastic mask over their head during imaging scans. These scans will pinpoint the exact location of the tumor. This spot will be the target of the radiation treatments. |
Participants will undergo radiation treatment 4 times per week. Some people will have this treatment for 3 weeks, some for 2 weeks, and some for 1 week. Blood tests and other exams will be repeated at each visit. |
Participants will complete questionnaires about their physical and mental health. They will answer these questions before starting radiation treatment; once a week during treatment; and at intervals for up to 3 years after treatment ends. |
Participants will have follow-up visits 1 month after treatment and then every 2 months for 6 months. Follow-up clinic visits will continue up to 3 years. Follow-ups by phone or email will continue an additional 2 years. conditions: Astrocytoma conditions: Glioma conditions: Recurrent Glioblastoma studyType: INTERVENTI... |
<|newrecord|> nctId: NCT06344117 id: MF3 UHN (IA) briefTitle: Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients acronym: UHN overallStatus: RECRUITING date: 2023-12-12 date: 2025-07 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: Owlstone... |
<|newrecord|> nctId: NCT06344104 id: D6970C00008 briefTitle: A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Asian Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension acronym: BaxAsia overallStatus: NOT_YET_RECRUITING date: ... |
<|newrecord|> nctId: NCT06344091 id: ZYWB-ZM-AHP-A-003 briefTitle: A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-06 date: 2026-09-28 date: 2026-10-12 date: 2024-04-03 date: 2024-04-03 name: Jiangsu HengRui Medicine Co., Ltd. class: IND... |
<|newrecord|> nctId: NCT06344078 id: SIGMA-d briefTitle: Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR). acronym: SIGMA-D overallStatus: RECRUITING dat... |
<|newrecord|> nctId: NCT06344065 id: 20220102C briefTitle: Immunogenicity and Safety of Diphtheria, Tetanus, Pertussis (DTaP) Vaccine in 3-month-old Infants overallStatus: RECRUITING date: 2023-12-21 date: 2025-05-25 date: 2028-12-25 date: 2024-04-03 date: 2024-04-03 name: Beijing Zhifei Lvzhu Biopharmaceutical Co., Lt... |
<|newrecord|> nctId: NCT06344052 id: SP-002-004 briefTitle: To Assess the Safety and Efficacy of SP-002 With Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma overallStatus: RECRUITING date: 2024-04-09 date: 2026-09-30 date: 2029-03-30 date: 2024-04-03 date: 2024-04-10 name: Stamford Pharmaceuticals... |
Researchers will compare the objective response rate for treated Basal cell carcinoma tumors between 3 treatment Arms. |
* Arm 1 participants will receive daily hedgehog pathway inhibitor, and 3 cycles of SP-002 treatment. |
* Arm 2 participants will receive daily hedgehog pathway inhibitor, and 1 cycle of SP-002 treatment. |
* Arm 3 participants will receive daily hedgehog pathway inhibitor only. conditions: Basal Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 80 type: ESTIMATED name: SP-002 name: Vismodegib measure: Objective respons... |
<|newrecord|> nctId: NCT06344039 id: Floating hip briefTitle: Epidemiological Study of Floating Hip Injuries in Assiut University Hospitals overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-05 date: 2024-04-03 date: 2024-04-05 name: Assiut University class: OTHER briefSummary: Aim of the study is... |
<|newrecord|> nctId: NCT06344026 id: ANPD001-02 briefTitle: Phase 1/2a Study of ANPD001 in Parkinson Disease acronym: ASPIRO overallStatus: ENROLLING_BY_INVITATION date: 2024-01-23 date: 2025-10-30 date: 2030-04-30 date: 2024-04-03 date: 2024-04-19 name: Aspen Neuroscience class: INDUSTRY name: California Institute for... |
<|newrecord|> nctId: NCT06344013 id: 29BRC24.0034 - BUNDLE ABCDEF briefTitle: The ABCDEF Bundle in Critical Care: a French National Survey Still a Long Way to go! overallStatus: COMPLETED date: 2022-07-01 date: 2022-07-31 date: 2022-07-31 date: 2024-04-03 date: 2024-04-03 name: University Hospital, Brest class: OTHER b... |
<|newrecord|> nctId: NCT06344000 id: RICU20240323 briefTitle: Study on Disease Progression and Nutritional Status in Bronchiectasis overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-04-15 date: 2027-04-15 date: 2024-04-03 date: 2024-04-03 name: Wuhan Union Hospital, China class: OTHER briefSummary: Bronchie... |
<|newrecord|> nctId: NCT06343987 id: 1-10-72-165-23 briefTitle: The FEMA Study: Feasibility of Exercise in Patients With Metastatic Breast Cancer and Adiposity overallStatus: RECRUITING date: 2024-02-19 date: 2024-12 date: 2025-03 date: 2024-04-03 date: 2024-04-09 name: Aarhus University Hospital class: OTHER name: Dan... |
The aim of the study is to assess the feasibility and metabolic efficacy of a 12-week physical activity program in this patient group. The hypothesis is that improving metabolic health through physical activity can optimize cancer care. |
Participants will randomized 2:1 to either a physical activity program or care as usual. conditions: Metastatic Breast Cancer conditions: Estrogen-receptor-positive Breast Cancer conditions: Adiposity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: C... |
<|newrecord|> nctId: NCT06343974 id: 0843 briefTitle: Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound Radiomics overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-31 date: 2026-05-01 date: 2024-04-03 date: 2024-04-03 name: Turku University Hospital class: OTHER_GOV briefSummary: The goal ... |
The main questions it aims to answer are: |
* Are fetal liver ultrasound radiomic features reproducible? |
* Does fetal liver ultrasound radiomics differ between pregnancies complicated by type 1 diabetes and healthy controls? |
Participants will undergo ultrasound examination to collect ultrasound data for the analyses. conditions: Pregnancy in Diabetic conditions: Diabetes Mellitus, Type 1 studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED measure: Fetal liver ultrasound texture m... |
<|newrecord|> nctId: NCT06343961 id: 2024-76 briefTitle: Intraoperative Application of Fluorescein Sodium Angiography in Vascular Retinopathy overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2025-12 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: Jie Zhong class: OTHER briefSummary: The study used a new s... |
<|newrecord|> nctId: NCT06343948 id: BL-B01D1-306 briefTitle: A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-05 date: 2026-05 date: 2024-04-03 da... |
<|newrecord|> nctId: NCT06343935 id: YY-20394-014 briefTitle: A National Multicenter, Real-world Study of Linperlisib in the Treatment of Lymphoma overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-04-30 date: 2025-04-30 date: 2024-04-03 date: 2024-04-03 name: Shanghai YingLi Pharmaceutical Co. Ltd. class: I... |
<|newrecord|> nctId: NCT06343922 id: Sadaf Riphah briefTitle: Oral Motor Facilitation Technique And Traditional Exercises on Children With Cerebral Palsy overallStatus: RECRUITING date: 2023-12-01 date: 2024-04 date: 2024-04 date: 2024-04-03 date: 2024-04-03 name: Riphah International University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06343909 id: REC/RCR & AHS/23/0197Ayesha briefTitle: Foot and Hip Abductor Strengthening in Patients With Knee Osteoarthritis. overallStatus: RECRUITING date: 2023-11-23 date: 2024-06-01 date: 2024-06-01 date: 2024-04-03 date: 2024-04-03 name: Riphah International University class: OTHER briefSu... |
Pre assessment will be done using pain, ROM, function, foot arches and knee alignment as subjective measurement through KOOS questionnaire, goniometer, 2D frontal plane projection, Berkemann foot prints using ink and paper ,30s chair stand test, nine step stair climb,40m fast paced walk test,Global rating of change sco... |
<|newrecord|> nctId: NCT06343896 id: AnkaraCHBilkent-tntaygurt briefTitle: Evaluation of Sedation Depth and Reliability With Integrated Pulmonary Index (IPI) Follow-up in Pediatric Radiological Interventions acronym: IPI overallStatus: RECRUITING date: 2024-04-01 date: 2024-06-15 date: 2024-10-15 date: 2024-04-03 date:... |
<|newrecord|> nctId: NCT06343883 id: 24-353 briefTitle: Investigation of Low-intensity Focused Ultrasound Pressure overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-07 date: 2026-07 date: 2024-04-03 date: 2024-04-03 name: Virginia Polytechnic Institute and State University class: OTHER briefSummary: Investigat... |
<|newrecord|> nctId: NCT06343870 id: ESTIME briefTitle: Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME) acronym: ESTIME overallStatus: NOT_YET_RECRUITING date: 2024-05-31 date: 2025-01-31 date: 2025-04-30 date: 2024-04-03 date: 2024-04-03 name: University of Sao Paulo General Hospital cla... |
<|newrecord|> nctId: NCT06343857 id: CE-AVEC 878/2022/Oss/AOUFe briefTitle: Joint Self-Assessment Forms for Knee, Ankle and Shoulder overallStatus: ACTIVE_NOT_RECRUITING date: 2023-05-01 date: 2024-04-30 date: 2024-04-30 date: 2024-04-03 date: 2024-04-03 name: University Hospital of Ferrara class: OTHER briefSummary: T... |
The pilot phase of the project involves the collection of data from questionnaires in a population of subjects who have requested an orthopaedic consultation for the anatomical site covered by the questionnaire. Each questionnaire consists of questions designed to collect information about the patient's subjective cond... |
The data collected from the questionnaires will be used to evaluate the statistical significance (p value) of each question in the questionnaire in relation to the outcome of the orthopaedic specialist visit. Through a multivariate logistic analysis of the answers given by the subject, it will be possible to 'weight' e... |
<|newrecord|> nctId: NCT06343844 id: 49RC23_0070 briefTitle: Disparities in Myocardial Infarction Remodeling According to Gender acronym: REMOVE 2 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2039-09-01 date: 2040-07-01 date: 2024-04-03 date: 2024-04-03 name: University Hospital, Angers class: OTHER_GOV bri... |
<|newrecord|> nctId: NCT06343831 id: IRB23-1646 briefTitle: Quantitative Assessment of Autologous Fat Transfer overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-12 date: 2024-04-03 date: 2024-04-03 name: University of Chicago class: OTHER name: National Institutes of Health (NIH) name: University... |
<|newrecord|> nctId: NCT06343818 id: NIHR301578 briefTitle: Compassion Project: Developing an Empathy-Based Stress Intervention overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2026-08-01 date: 2027-08-31 date: 2024-04-03 date: 2024-04-03 name: University of Bath class: OTHER name: National Institute for Health... |
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