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Staff experiencing empathy-based stress deliver less high quality care, which can lead to serious consequences for patients. Empathy-based stress is also associated with staff sickness, which is bad for staff and costly to the United Kingdom's National Health Service (NHS). |
Child and adolescent mental health (CAMHS) wards are busy, high-pressure environments where families and young people are often upset, resources are stretched, and staff are managing high levels of patient risk of self-harm or suicide. |
The principal investigator has already reviewed research on empathy-based stress and interventions to prevent and/or reduce it in mental health ward staff. This evidence has been presented to CAMHS ward staff, managers, commissioners, patients and families and these stakeholders have co-designed an intervention for war... |
This pilot study aims to test and improve our intervention on two CAMHS wards, measuring how useful and well-liked it is, and how feasible it would be to use it and to test it on more wards. Staff on CAMHS wards will be offered a modular intervention including psychoeducation about empathy based stress and ways of comb... |
<|newrecord|> nctId: NCT06343805 id: AJX-101 briefTitle: A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i) overallStatus: NOT_YET_RECRU... |
<|newrecord|> nctId: NCT06343792 id: RLS-0071-203 briefTitle: Safety, PK, PD, Dosing, and Efficacy of RLS-0071for the Treatment of Hospitalized Patients With Steroid-Refractory Acute Graft-versus-Host Disease acronym: AURORA overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-09 date: 2024-04-03 da... |
<|newrecord|> nctId: NCT06343779 id: PHA022121-C306 briefTitle: Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema acronym: RAPIDe-3 overallStatus: RECRUITING date: 2024-02-26 date: 2026-03 date: 2026-03 date: 2024-04-03 date: 2024... |
<|newrecord|> nctId: NCT06343766 id: RECO6U/24-2022 briefTitle: Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS. overallStatus: COMPLETED date: 2022-11-06 date: 2023-11-05 date: 2023-11-05 date: 2024-04-03 date: 2024-04-03 name: Amina Fouad Farag class: OTHER briefSummary: A Cross-Sectional Study aims to shed l... |
<|newrecord|> nctId: NCT06343753 id: FMASU MD46/2024 briefTitle: Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free Anesthesia overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-10-01 date: 2024-04-03 date: 2024-04-03 name: Ain Shams Uni... |
<|newrecord|> nctId: NCT06343740 id: PSY-2324-S-0136 briefTitle: First Evaluation of COMET-Y acronym: COMET-Y overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: Accare class: OTHER briefSummary: The goal of this pilot study is to evaluate COMET-Y in 22 ad... |
Before and after the training participants fill in questionnaires to measure self-esteem, mental health problems, resilience, quality of life, emotions and individual goals. Some of the outcomes are measured through diary methods. Youth and therapists will be assessed to evaluate feasibility and acceptability of the CO... |
<|newrecord|> nctId: NCT06343727 id: HS25870 (H2023:026) briefTitle: A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-07-01 date: 2024-04-03 date: 2024-04-03 name: Seven Oaks Hospital Chronic Disease Innovation Centr... |
* To determine whether the supplementation of egg white protein pudding in a population of individuals with kidney failure on dialysis is feasible. |
* To determine whether egg white protein pudding supplementation improves serum albumin similar to other standard nutritional supplements. |
* To determine the effects of the egg white protein pudding on frailty measures, dietary intakes and analytes in the blood and urine. Participants will receive either the egg white pudding (experimental) or control (Ensure plus) at the end of their dialysis treatments 3-days per week for 12 weeks. conditions: Kidney Fa... |
<|newrecord|> nctId: NCT06343714 id: FB1003-04-101 briefTitle: A Study of FB1003 in Healthy Subject overallStatus: NOT_YET_RECRUITING date: 2024-04-03 date: 2025-06-30 date: 2025-06-30 date: 2024-04-03 date: 2024-04-03 name: 4B Technologies Limited class: INDUSTRY briefSummary: The purpose of this study is to evaluate ... |
<|newrecord|> nctId: NCT06343701 id: BAİBÜ-SAT4 briefTitle: Investigation of Motor Imaging Skills in Children With Spastic Cerebral Palsy overallStatus: RECRUITING date: 2023-07-18 date: 2024-05-05 date: 2024-06-25 date: 2024-04-03 date: 2024-04-03 name: Abant Izzet Baysal University class: OTHER briefSummary: The aim ... |
* There is a difference between the implicit motor imagery skills of children with bilateral and unilateral CP. |
* There is a difference between the explicit motor imagery skills of children with bilateral and unilateral CP. |
* There is a difference between the implicit motor imagery skills of children with cerebral palsy and typically developing children. |
* There is a difference between the explicit motor imagery skills of children with cerebral palsy and typically developing children. conditions: Cerebral Palsy, Spastic studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 90 type: ESTIMATED name: Implicit motor imagery name: Explicit m... |
<|newrecord|> nctId: NCT06343688 id: BAIBU-FTR-SAT-5 briefTitle: "Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-01 date: 2025-04-01 date: 2024-04-03 date: 2024-04-03 name: Abant Izzet Baysal University class: OTHE... |
<|newrecord|> nctId: NCT06343675 id: Dnr 2024-00620-01 briefTitle: Systematic Health-promoting Work Environment Management in Dentistry overallStatus: RECRUITING date: 2024-04-04 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-05 name: Linkoeping University class: OTHER_GOV briefSummary: Research shows... |
<|newrecord|> nctId: NCT06343662 id: Meraki_Acquired Brain Injury briefTitle: Group Music Therapy for Acquired Brain Injury acronym: Meraki_ABI overallStatus: RECRUITING date: 2024-03-01 date: 2024-07 date: 2025-07 date: 2024-04-02 date: 2024-04-15 name: University of Valencia class: OTHER briefSummary: The study aims ... |
<|newrecord|> nctId: NCT06343649 id: CEUMA 187-2023-H briefTitle: Explicit Motor Imagery in Persistent Pelvic Pain overallStatus: COMPLETED date: 2023-11-01 date: 2023-11-30 date: 2023-11-30 date: 2024-04-02 date: 2024-04-23 name: University of Valencia class: OTHER briefSummary: The goal of this clinical trial is to c... |
• Does the modality of application of Explicit Motor Imagery, either through visual or auditory stimuli, influence the response in patients suffering Persistent Pelvic Pain? |
Participants will receive an online Explicit Motor Imagery program either through visual inputs or auditory inputs. They will be instructed to follow the program en register their response. |
Researchers will compare visual Explicit Motor Imagery and auditory Explicit Motor Imagery to see if different inputs generate different responses in patients suffering Persistent Pelvic Pain. conditions: Pelvic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose:... |
<|newrecord|> nctId: NCT06343636 id: VG3927-02.101 briefTitle: A Phase 1 Study of VG-3927 in Healthy Adults overallStatus: ENROLLING_BY_INVITATION date: 2023-09-27 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: Vigil Neuroscience, Inc. class: INDUSTRY briefSummary: A Phase 1, First-in-human, ... |
<|newrecord|> nctId: NCT06343623 id: fac.med.2018.15 briefTitle: Superiorly Based Pharyngeal Flap Versus Myomucosal Resection and Direct Closure overallStatus: COMPLETED date: 2018-10-12 date: 2022-10-16 date: 2022-10-16 date: 2024-04-02 date: 2024-04-02 name: Minia University class: OTHER briefSummary: Patients were c... |
<|newrecord|> nctId: NCT06343610 id: VIST TO-UV 01-2024 briefTitle: The Effect of 8-week Dietary Intake of Novel Food Supplement on Minimal Erythema Dose acronym: VIST-TO-UV overallStatus: RECRUITING date: 2024-04 date: 2024-07 date: 2024-10 date: 2024-04-02 date: 2024-04-02 name: VIST - Faculty of Applied Sciences cla... |
<|newrecord|> nctId: NCT06343597 id: 037.HPB.2020.R briefTitle: Volume Outcome Relationships and Effects overallStatus: RECRUITING date: 2020-06-15 date: 2025-06-15 date: 2025-06-15 date: 2024-04-02 date: 2024-04-02 name: Methodist Health System class: OTHER briefSummary: This is a retrospective analysis to assess if h... |
<|newrecord|> nctId: NCT06343584 id: 023.NUR.2021.M briefTitle: Are Personal Smartphones Hurting Work-Life Balance for Nurse Managers? overallStatus: COMPLETED date: 2021-07-01 date: 2022-05-06 date: 2022-05-06 date: 2024-04-02 date: 2024-04-02 name: Methodist Health System class: OTHER briefSummary: For leadership pos... |
<|newrecord|> nctId: NCT06343571 id: MED-EL_CRD_2022_12 briefTitle: Longitudinal Outcomes in MED-EL Cochlear Implant Recipients Using a FLEX Electrode acronym: LOTOS overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2024-08 date: 2024-04-02 date: 2024-04-02 name: MED-EL Elektromedizinische Geräte Gesm... |
<|newrecord|> nctId: NCT06343558 id: 24C302 briefTitle: Gait and Balance Impairment in Rare and Very Rare Neurological Diseases acronym: GALVANISE overallStatus: RECRUITING date: 2023-05-30 date: 2027-05-01 date: 2027-05-01 date: 2024-04-02 date: 2024-04-02 name: Istituto Auxologico Italiano class: OTHER name: IRCCS Is... |
Rare, very rare, and undiagnosed neurological diseases are complicated and progressive and often cause variegated motor signs, impairments, and syndromes. |
Balance and gait are frequently affected in these conditions, already at the clinical examination. These balance and gait impairments limit activities and cause an increased risk of falling. Falls can eventually result in injuries, even severe. |
There are only a few studies about these diseases, likely because of their rarity. Hence, the clinical presentation and the course of rare and very rare diseases are poorly known or even unknown. Essential information for these conditions' diagnosis, prognosis, treatment and rehabilitation is missing. |
MaNeNeND is an observational study underway at the Fondazione IRCCS Istituto Neurologico "Carlo Besta" (Milano) aimed at detailing the clinical and biological features of very rare and undiagnosed neurological diseases. |
Research questions: |
1. Do patients with rare (Ra), very rare (V) and undiagnosed (U) neurological diseases suffer a balance and gait impairment? |
2. Is there a correlation between the clinical and instrumental severity of the balance and gait impairment in RaVU neurological diseases? |
3. Are instrumental measures more sensitive in detecting balance and gait impairments in patients affected by a RaVU neurological disease than the clinical measures? |
4. Do the balance and gait impairments in RaVU neurological diseases worsen in time? |
The current project aims at diagnosing, quantifying and detailing the balance and gait impairment in rare, very rare and undiagnosed neurological diseases. |
To this aim, questionnaires, clinical scales and instrumental tests will be administered to these patients to collect a wide range of balance and gait measures. |
These measures will also integrate those collected with MaNeNeND to provide a more detailed description of patients with rare, very rare and diagnosed neurological diseases. |
Participants will complete two questionnaires: the Dizziness Handicap Inventory - short form (DHI-sf, an ordinal score of self-perceived balance) and the Modified Fatigue Impact Scale (MFIS, an ordinal score of self-perceived fatigue). |
Moreover, a clinician will administer the Mini Balance Evaluation Systems Test (Mini-BESTest, an ordinal score of balance), the 10 m walking test (for measuring the gait speed and other gait parameters) and the Timed Up and Go test (an instrumental measure of mobility and balance). Walking and the Timed Up and Go tests... |
Finally, participants will be asked to complete an instrumental upright stance and gait assessment, the first consisting of standing on posturographic plates and the second of walking on a treadmill equipped with force sensors. When walking on the treadmill, an optoelectronic system will also record the position in tim... |
The quantification of the severity of the balance and gait impairment of the patients suffering a rare, very rare or undiagnosed neurological disease will highlight these persons' therapeutic and rehabilitative needs. |
Comparing the balance and gait impairment of rare, very rare and undiagnosed diseases with those of multiple sclerosis, Parkinson's disease and peripheral neuropathy will highlight if the formers' balance and gait impairment has unique characteristics that could help ease the diagnosis of these uncommon conditions. |
The longitudinal measurements on rare, very rare and undiagnosed diseases will be paramount to identifying prognostic factors. |
In addition, the data collected in the current study will be crucial for future studies, for example, for estimating the sample size in clinical trials. conditions: Multiple Sclerosis conditions: Parkinson Disease conditions: Peripheral Neuropathy conditions: Rare Diseases conditions: Healthy conditions: Healthy Aging ... |
<|newrecord|> nctId: NCT06343545 id: Rehab_PROADI briefTitle: Evaluation of the Impact of Rehabilitation Strategies and Early Discharge After Respiratory Failure acronym: Rehab overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-07-30 date: 2026-12-31 date: 2024-04-02 date: 2024-04-02 name: Hospital Israelita... |
<|newrecord|> nctId: NCT06343532 id: NIDA-SXC-Ph1b-001 briefTitle: SXC-2023 Cocaine Interaction Study overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-12 date: 2024-12 date: 2024-04-02 date: 2024-04-02 name: National Institute on Drug Abuse (NIDA) class: NIH name: Promentis Pharmaceuticals, Inc. name: Altasci... |
<|newrecord|> nctId: NCT06343519 id: Shocked Patients Monitoring briefTitle: Echocardiographic and Laboratory Findings in Hemodynamic Monitoring of Shocked Patients overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-03 date: 2026-05 date: 2024-04-02 date: 2024-04-02 name: Assiut University class: OTHER briefSum... |
<|newrecord|> nctId: NCT06343506 id: 2023-929-EXPEDITED briefTitle: Ankle Dorsiflexion Changes With Assisted Stretching Device overallStatus: RECRUITING date: 2023-10-30 date: 2024-06-01 date: 2024-12-31 date: 2024-04-02 date: 2024-04-04 name: Montana State University class: OTHER briefSummary: Ankle range of motion is... |
<|newrecord|> nctId: NCT06343493 id: JALTAF briefTitle: Effect of Hot Saline Irrigation on the Operative Field During Endoscopic Sinus Surgery overallStatus: COMPLETED date: 2023-06-16 date: 2023-12-15 date: 2023-12-31 date: 2024-04-02 date: 2024-04-02 name: Rawalpindi Medical College class: OTHER briefSummary: Control... |
This randomized controlled trial was conducted on 60 patients divided into two groups (30 each). Group A was the interventional group in which patients were irrigated with saline of 50°C during surgery. Group B was the control group where room temperature saline was used. Operative field was assessed using the Boezaart... |
KEY WORDS: |
* Chronic rhinosinusitis (CRS) |
* Endoscopic sinus surgery |
* Boezaart score conditions: Rhinosinusitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ACTUAL name: Normal saline heated up to 50 °C measure: Boe... |
<|newrecord|> nctId: NCT06343480 id: SMVOT2024CT briefTitle: Misoprostol Versus Oxytocin for Induction of Labour in Parturients With Spontaneous Rupture of Fetal Membranes at Term overallStatus: COMPLETED date: 2020-09-01 date: 2021-08-31 date: 2021-11-30 date: 2024-04-02 date: 2024-04-02 name: Federal Teaching Hospita... |
<|newrecord|> nctId: NCT06343467 id: A17-376 briefTitle: Do Generic Volar Locking Plates Provide Similar Outcomes at a Reduced Cost? overallStatus: COMPLETED date: 2022-11-01 date: 2023-04-30 date: 2023-04-30 date: 2024-04-02 date: 2024-04-02 name: HealthPartners Institute class: OTHER briefSummary: Across orthopedics,... |
<|newrecord|> nctId: NCT06343454 id: 2023/04-03(KA-22111) briefTitle: The Effect of Different Head Positions on Occlusal Contacts During Digital Interocclusal Bite Registration overallStatus: COMPLETED date: 2023-10-25 date: 2024-01-27 date: 2024-03-03 date: 2024-04-02 date: 2024-04-02 name: Hacettepe University class:... |
• Are different head positions in physiological limits can be affected the occlusal contact during interocclusal record? Participants will be asked to stand in three different physiological head positions (neutral, forward and backward) which are common in daily routine. In these positions, after maxillary and mandibul... |
Researchers will compare neutral, forward and backward head positions to see if there are any difference in number, density and location of occlusal contacts. conditions: Occlusion studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoM... |
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